EIF2S2P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)9.91621943
2activation of protein kinase A activity (GO:0034199)9.75615028
3negative regulation of type 2 immune response (GO:0002829)9.66622072
4regulation of T-helper 2 cell differentiation (GO:0045628)9.56979246
5positive regulation of RNA splicing (GO:0033120)9.53985793
6seminiferous tubule development (GO:0072520)9.34437100
7negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.78716898
8cAMP biosynthetic process (GO:0006171)8.49636870
9detection of chemical stimulus involved in sensory perception (GO:0050907)8.37368638
10negative regulation of alpha-beta T cell differentiation (GO:0046639)8.14110831
11enteric nervous system development (GO:0048484)7.96736896
12dendritic spine morphogenesis (GO:0060997)7.24191989
13synaptic transmission, dopaminergic (GO:0001963)7.14338887
14regulation of protein sumoylation (GO:0033233)7.13853099
15positive regulation of mitochondrial fission (GO:0090141)6.93729384
16righting reflex (GO:0060013)6.78510605
17positive regulation of T-helper 1 type immune response (GO:0002827)6.32581288
18heterotypic cell-cell adhesion (GO:0034113)6.18007329
19detection of chemical stimulus (GO:0009593)5.99856697
20endothelial cell differentiation (GO:0045446)5.90783421
21icosanoid secretion (GO:0032309)5.86900809
22arachidonic acid secretion (GO:0050482)5.86900809
23hepatocyte apoptotic process (GO:0097284)5.70988643
24positive regulation of T-helper cell differentiation (GO:0045624)5.58088097
25phosphatidylinositol acyl-chain remodeling (GO:0036149)5.38238820
26phosphatidylserine acyl-chain remodeling (GO:0036150)5.32180670
27phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.20843424
28regulation of mitochondrial fission (GO:0090140)5.16519231
29neural tube formation (GO:0001841)5.06069767
30drug transmembrane transport (GO:0006855)4.99554455
31chemosensory behavior (GO:0007635)4.85395841
32icosanoid transport (GO:0071715)4.83742660
33fatty acid derivative transport (GO:1901571)4.83742660
34neuronal ion channel clustering (GO:0045161)4.83279329
35embryonic digestive tract morphogenesis (GO:0048557)4.66794576
36negative regulation of alpha-beta T cell activation (GO:0046636)4.66295475
37nephron epithelium morphogenesis (GO:0072088)4.65090736
38nephron tubule morphogenesis (GO:0072078)4.65090736
39vocalization behavior (GO:0071625)4.53072887
40cilium or flagellum-dependent cell motility (GO:0001539)4.51077778
41regulation of T-helper 1 type immune response (GO:0002825)4.50222434
42retina layer formation (GO:0010842)4.48580219
43energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.42392309
44ATP hydrolysis coupled proton transport (GO:0015991)4.42392309
45attachment of spindle microtubules to kinetochore (GO:0008608)4.34260523
46protein localization to synapse (GO:0035418)4.31924433
47positive regulation of membrane potential (GO:0045838)4.30049437
48hyaluronan catabolic process (GO:0030214)4.29729706
49cyclic purine nucleotide metabolic process (GO:0052652)4.28082086
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.22840555
51cyclic nucleotide biosynthetic process (GO:0009190)4.18395187
52regulation of cAMP-mediated signaling (GO:0043949)4.10637093
53response to dietary excess (GO:0002021)4.07259428
54cellular response to glucagon stimulus (GO:0071377)4.04970014
55regulation of T-helper cell differentiation (GO:0045622)4.02913453
56cAMP metabolic process (GO:0046058)3.97566204
57mitochondrial fusion (GO:0008053)3.96573456
58water transport (GO:0006833)3.91837359
59dendritic spine organization (GO:0097061)3.91290595
60phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.87654236
61negative regulation of actin filament bundle assembly (GO:0032232)3.87311653
62regulation of type 2 immune response (GO:0002828)3.86224644
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.85704604
64positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.70482113
65cellular response to ATP (GO:0071318)3.66137500
66negative regulation of T cell differentiation (GO:0045581)3.63030898
67left/right axis specification (GO:0070986)3.59392680
68positive regulation of protein targeting to membrane (GO:0090314)3.57936148
69monoamine transport (GO:0015844)3.57757801
70neurofilament cytoskeleton organization (GO:0060052)3.56590025
71pre-miRNA processing (GO:0031054)3.49500963
72fluid transport (GO:0042044)3.48418248
73negative regulation of astrocyte differentiation (GO:0048712)3.48304851
74drug transport (GO:0015893)3.41852842
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.41530404
76leukotriene biosynthetic process (GO:0019370)3.39762779
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38338404
78renal tubule morphogenesis (GO:0061333)3.38003506
79sulfur amino acid catabolic process (GO:0000098)3.37257839
80phosphatidylcholine acyl-chain remodeling (GO:0036151)3.32082722
81cellular zinc ion homeostasis (GO:0006882)3.30398557
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23995062
83positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.20053425
84positive regulation of alpha-beta T cell differentiation (GO:0046638)3.19705041
85reflex (GO:0060004)3.16811326
86hindbrain development (GO:0030902)3.16362242
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15582336
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.15365464
89prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.10474575
90negative regulation of homotypic cell-cell adhesion (GO:0034111)3.10226708
91neuromuscular process controlling posture (GO:0050884)3.08960963
92adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.08014069
93sequestering of metal ion (GO:0051238)3.06189395
94response to glucagon (GO:0033762)3.05397715
95tooth mineralization (GO:0034505)13.9528076
96detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.4016238
97positive regulation of protein sumoylation (GO:0033235)11.4907759
98negative regulation of T-helper cell differentiation (GO:0045623)10.9753273
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.9753273
100protein K11-linked deubiquitination (GO:0035871)10.4830262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.78551991
2AR_21572438_ChIP-Seq_LNCaP_Human4.86582067
3IGF1R_20145208_ChIP-Seq_DFB_Human4.78619953
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.59478319
5VDR_22108803_ChIP-Seq_LS180_Human4.48980609
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.04439897
7PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.19319443
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.16259882
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16259882
10TP53_16413492_ChIP-PET_HCT116_Human2.07053790
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02574826
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.1993767
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99517429
14EZH2_22144423_ChIP-Seq_EOC_Human1.97617258
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.84734537
16YY1_22570637_ChIP-Seq_MALME-3M_Human1.77471196
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76551352
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.74852221
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73303111
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69003867
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68406568
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65208888
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64089763
24DROSHA_22980978_ChIP-Seq_HELA_Human1.59768086
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55647224
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.52330658
27SMAD3_21741376_ChIP-Seq_HESCs_Human1.52106097
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49527064
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.47579779
30RNF2_27304074_Chip-Seq_NSC_Mouse1.47324733
31GATA1_19941826_ChIP-Seq_K562_Human1.45593354
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.44285022
33GBX2_23144817_ChIP-Seq_PC3_Human1.41588579
34EGR1_19032775_ChIP-ChIP_M12_Human1.37541078
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.34719920
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34324995
37RXR_22108803_ChIP-Seq_LS180_Human1.32729231
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30930595
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28893560
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28081100
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.27095421
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26630373
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24559877
44ER_23166858_ChIP-Seq_MCF-7_Human1.22467724
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20138172
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19641161
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17972901
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17176656
49TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.15228544
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14446852
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14279936
52ZNF274_21170338_ChIP-Seq_K562_Hela1.14179987
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.12962979
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11484805
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09282314
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07959586
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07948437
58REST_21632747_ChIP-Seq_MESCs_Mouse1.07626130
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06619617
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.06147654
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.05826510
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.05290064
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03606835
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03606835
65TBL1_22424771_ChIP-Seq_293T_Human1.02306450
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.02233136
67STAT3_23295773_ChIP-Seq_U87_Human1.01642301
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01544761
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.00930470
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.00505696
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.00187686
72BCAT_22108803_ChIP-Seq_LS180_Human0.99695730
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98741315
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97950825
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96348824
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95344668
77PHF8_20622853_ChIP-Seq_HELA_Human0.94159211
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92359838
79SMAD4_21799915_ChIP-Seq_A2780_Human0.91458692
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91360714
81SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91202917
82E2F1_18555785_Chip-Seq_ESCs_Mouse0.90942221
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89422127
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.87228266
85RING1B_27294783_Chip-Seq_ESCs_Mouse0.86544555
86AR_25329375_ChIP-Seq_VCAP_Human0.85215566
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.85206424
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84548129
89KLF4_18555785_Chip-Seq_ESCs_Mouse0.84231051
90P53_22387025_ChIP-Seq_ESCs_Mouse0.84123979
91CTCF_27219007_Chip-Seq_Bcells_Human0.84003643
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83935017
93NANOG_16518401_ChIP-PET_MESCs_Mouse0.83739845
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83568078
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.83479231
96CJUN_26792858_Chip-Seq_BT549_Human0.82960976
97TCF4_22108803_ChIP-Seq_LS180_Human0.82731654
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81900998
99CBP_20019798_ChIP-Seq_JUKART_Human0.81242097
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81242097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.45525049
2MP0004130_abnormal_muscle_cell4.78994363
3MP0004264_abnormal_extraembryonic_tissu3.65499440
4MP0003252_abnormal_bile_duct3.37042276
5MP0004133_heterotaxia3.31041180
6MP0002928_abnormal_bile_duct2.79632592
7MP0006072_abnormal_retinal_apoptosis2.65561732
8MP0002751_abnormal_autonomic_nervous2.40164418
9MP0005448_abnormal_energy_balance2.22786918
10MP0001270_distended_abdomen2.08679003
11MP0005408_hypopigmentation2.05685677
12MP0005084_abnormal_gallbladder_morpholo12.3241726
13MP0003329_amyloid_beta_deposits1.88217555
14MP0005220_abnormal_exocrine_pancreas1.79908294
15MP0004272_abnormal_basement_membrane1.76865146
16MP0001529_abnormal_vocalization1.70724032
17MP0003943_abnormal_hepatobiliary_system1.69170532
18MP0005379_endocrine/exocrine_gland_phen1.54765578
19MP0009764_decreased_sensitivity_to1.30753714
20MP0005165_increased_susceptibility_to1.25141855
21MP0003718_maternal_effect1.23347226
22MP0005646_abnormal_pituitary_gland1.19983369
23MP0002572_abnormal_emotion/affect_behav1.18727646
24MP0001958_emphysema1.17469981
25MP0000604_amyloidosis1.14282251
26MP0001905_abnormal_dopamine_level1.13951186
27MP0000470_abnormal_stomach_morphology1.08384471
28MP0002909_abnormal_adrenal_gland1.08209281
29MP0001944_abnormal_pancreas_morphology1.06743167
30MP0003121_genomic_imprinting1.04008093
31MP0008569_lethality_at_weaning0.99899243
32MP0003638_abnormal_response/metabolism_0.95764105
33MP0004019_abnormal_vitamin_homeostasis0.89075771
34MP0008875_abnormal_xenobiotic_pharmacok0.80003615
35MP0005253_abnormal_eye_physiology0.78552319
36MP0005423_abnormal_somatic_nervous0.77055248
37MP0000371_diluted_coat_color0.77016816
38MP0002693_abnormal_pancreas_physiology0.75147387
39MP0000465_gastrointestinal_hemorrhage0.74126339
40MP0005164_abnormal_response_to0.68537381
41MP0008469_abnormal_protein_level0.63866713
42MP0001915_intracranial_hemorrhage0.63760220
43MP0003866_abnormal_defecation0.63382989
44MP0003953_abnormal_hormone_level0.63007703
45MP0002822_catalepsy0.60177678
46MP0002078_abnormal_glucose_homeostasis0.58637663
47MP0001986_abnormal_taste_sensitivity0.58419904
48MP0005551_abnormal_eye_electrophysiolog0.57802470
49MP0001299_abnormal_eye_distance/0.56873581
50MP0002098_abnormal_vibrissa_morphology0.56493581
51MP0003880_abnormal_central_pattern0.55725818
52MP0003195_calcinosis0.54995564
53MP0002277_abnormal_respiratory_mucosa0.54860885
54MP0001800_abnormal_humoral_immune0.53819224
55MP0002735_abnormal_chemical_nociception0.53698413
56MP0000609_abnormal_liver_physiology0.53385853
57MP0002136_abnormal_kidney_physiology0.53362761
58MP0002882_abnormal_neuron_morphology0.52481699
59MP0002405_respiratory_system_inflammati0.51144773
60MP0000703_abnormal_thymus_morphology0.49167866
61MP0003136_yellow_coat_color0.46045659
62MP0001851_eye_inflammation0.43972480
63MP0001440_abnormal_grooming_behavior0.43780456
64MP0002736_abnormal_nociception_after0.43602567
65MP0000631_abnormal_neuroendocrine_gland0.41725607
66MP0001501_abnormal_sleep_pattern0.41651841
67MP0009642_abnormal_blood_homeostasis0.41597691
68MP0003011_delayed_dark_adaptation0.40948946
69MP0001790_abnormal_immune_system0.40751505
70MP0005387_immune_system_phenotype0.40751505
71MP0000566_synostosis0.39138329
72MP0001968_abnormal_touch/_nociception0.37922540
73MP0002938_white_spotting0.37766097
74MP0010030_abnormal_orbit_morphology0.36573961
75MP0002229_neurodegeneration0.36022390
76MP0001533_abnormal_skeleton_physiology0.35439589
77MP0002066_abnormal_motor_capabilities/c0.34729900
78MP0002998_abnormal_bone_remodeling0.34369372
79MP0002063_abnormal_learning/memory/cond0.34331885
80MP0002102_abnormal_ear_morphology0.34294008
81MP0006276_abnormal_autonomic_nervous0.34000124
82MP0003635_abnormal_synaptic_transmissio0.33917896
83MP0003315_abnormal_perineum_morphology0.32411196
84MP0005334_abnormal_fat_pad0.31215904
85MP0004742_abnormal_vestibular_system0.30561842
86MP0002557_abnormal_social/conspecific_i0.30407920
87MP0005195_abnormal_posterior_eye0.30362428
88MP0005391_vision/eye_phenotype0.30077864
89MP0000049_abnormal_middle_ear0.30001675
90MP0005503_abnormal_tendon_morphology0.28990514
91MP0005645_abnormal_hypothalamus_physiol0.28741018
92MP0001845_abnormal_inflammatory_respons0.28719928
93MP0001293_anophthalmia0.28339539
94MP0009053_abnormal_anal_canal0.28064109
95MP0000477_abnormal_intestine_morphology0.27952950
96MP0006292_abnormal_olfactory_placode0.27213624
97MP0004947_skin_inflammation0.27185868
98MP0002722_abnormal_immune_system0.27033086
99MP0002752_abnormal_somatic_nervous0.26583627
100MP0005377_hearing/vestibular/ear_phenot0.26142351

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.67249848
2Abnormality of renal resorption (HP:0011038)8.31633657
3Osteomalacia (HP:0002749)8.10635575
4Abnormality of dental color (HP:0011073)8.09735066
5Abnormality of the dental pulp (HP:0006479)7.53879487
6Polyuria (HP:0000103)7.51034372
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.91203539
8Abnormal urine output (HP:0012590)6.38929815
9Abnormality of renal excretion (HP:0011036)5.68002828
10Round ear (HP:0100830)4.82458218
11Chronic bronchitis (HP:0004469)4.80292911
12Volvulus (HP:0002580)4.49981727
13Molar tooth sign on MRI (HP:0002419)4.16017598
14Abnormality of midbrain morphology (HP:0002418)4.16017598
15IgM deficiency (HP:0002850)3.84318627
16Lip pit (HP:0100267)3.80734573
17Nephrocalcinosis (HP:0000121)3.76979437
18Abnormal respiratory motile cilium physiology (HP:0012261)3.66347854
19Toxemia of pregnancy (HP:0100603)3.65601168
20Rhinitis (HP:0012384)3.56525042
21Large earlobe (HP:0009748)3.52944937
22Drooling (HP:0002307)3.48357837
23Depressed nasal tip (HP:0000437)3.45971676
24Autoimmune thrombocytopenia (HP:0001973)3.42925512
25Excessive salivation (HP:0003781)3.30554148
26Tachypnea (HP:0002789)3.27639652
27Esophageal varix (HP:0002040)3.26015194
28Hyperphosphaturia (HP:0003109)3.08685945
29Lipoatrophy (HP:0100578)3.03780453
30Nephronophthisis (HP:0000090)2.98931320
31Sparse lateral eyebrow (HP:0005338)2.90518202
32Panhypogammaglobulinemia (HP:0003139)2.87574738
33Intestinal fistula (HP:0100819)2.82458304
34Thick eyebrow (HP:0000574)2.81330428
35Hypoparathyroidism (HP:0000829)2.73471640
36Abnormal urine phosphate concentration (HP:0012599)2.70494630
37Abnormality of urine glucose concentration (HP:0011016)2.62601551
38Glycosuria (HP:0003076)2.62601551
39Inability to walk (HP:0002540)2.56580189
40Personality changes (HP:0000751)2.56551970
41Chronic mucocutaneous candidiasis (HP:0002728)2.42441841
42Recurrent cutaneous fungal infections (HP:0011370)2.42441841
43Abnormality of the fingertips (HP:0001211)2.38507682
44Abnormality of the renal medulla (HP:0100957)2.31167023
45Ureteral stenosis (HP:0000071)2.30647895
46Decreased muscle mass (HP:0003199)2.28297593
47Hypercalciuria (HP:0002150)2.24337764
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.21214137
49Abnormality of salivation (HP:0100755)2.20873741
50Gingival overgrowth (HP:0000212)2.20766005
51Hepatitis (HP:0012115)2.20501018
52Dilated cardiomyopathy (HP:0001644)2.19906625
53Prominent supraorbital ridges (HP:0000336)2.19640519
54Short 5th finger (HP:0009237)2.17943262
55Ureteral obstruction (HP:0006000)2.17118891
56Nephropathy (HP:0000112)2.16033892
57Petechiae (HP:0000967)2.09463320
58Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09452523
59Preauricular pit (HP:0004467)2.05871049
60Periauricular skin pits (HP:0100277)2.05871049
61Bronchitis (HP:0012387)2.01703729
62Chorioretinal coloboma (HP:0000567)2.01317674
63Abnormality of transition element cation homeostasis (HP:0011030)2.00524619
64Overgrowth (HP:0001548)11.7007729
65Amelogenesis imperfecta (HP:0000705)11.0592201
66Delayed eruption of teeth (HP:0000684)1.98357435
67Anal stenosis (HP:0002025)1.96957541
68Small hand (HP:0200055)1.93411267
69Striae distensae (HP:0001065)1.92799734
70Sudden cardiac death (HP:0001645)1.90009063
71Ectopic kidney (HP:0000086)1.87838473
72Limited elbow extension (HP:0001377)1.85809021
73Renal tubular dysfunction (HP:0000124)1.85333996
74Chondrocalcinosis (HP:0000934)1.84456125
75Preauricular skin tag (HP:0000384)1.82904630
76Colitis (HP:0002583)1.81929045
77Abnormality of Sharpey fibers (HP:0100685)1.79931229
78Agammaglobulinemia (HP:0004432)1.79702210
79Recurrent otitis media (HP:0000403)1.79520147
80Oculomotor apraxia (HP:0000657)1.62451094
81Stage 5 chronic kidney disease (HP:0003774)1.62179622
82Truncal ataxia (HP:0002078)1.61910281
83Villous atrophy (HP:0011473)1.60632840
84Abnormality of small intestinal villus morphology (HP:0011472)1.60632840
85Skin tags (HP:0010609)1.58030509
86Highly arched eyebrow (HP:0002553)1.56591644
87Bronchiectasis (HP:0002110)1.56275765
88Torticollis (HP:0000473)1.55815086
89Septo-optic dysplasia (HP:0100842)1.55750002
90Palmoplantar keratoderma (HP:0000982)1.49178911
91Skin pits (HP:0100276)1.43428070
92Growth hormone deficiency (HP:0000824)1.43064722
93Prenatal maternal abnormality (HP:0002686)1.41465338
94Blepharitis (HP:0000498)1.37397079
95Concave nail (HP:0001598)1.36131731
96Widely spaced teeth (HP:0000687)1.32033453
97Ectropion (HP:0000656)1.29761310
98Proximal placement of thumb (HP:0009623)1.27385364
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.25647027
100Delayed gross motor development (HP:0002194)1.25523117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.31710677
2BLK4.22634676
3STK33.84131418
4RIPK42.82392159
5CDC42BPA2.05678318
6NTRK214.0427953
7BMPR21.76413387
8HIPK21.15868566
9INSRR1.12694253
10FGFR10.90704819
11ADRBK20.87348081
12WNK30.87027244
13CASK0.82780258
14TLK10.77534140
15ROCK20.76395613
16GRK10.69771697
17OBSCN0.66243968
18MARK10.64027306
19MUSK0.63785881
20SYK0.60482883
21SRC0.57158773
22TNIK0.57037646
23PRKAA10.56828570
24EPHA40.55954650
25PRKCQ0.55260446
26MAPK150.53598465
27PNCK0.50909483
28ROCK10.50317258
29MAP4K20.50053342
30GRK70.48846656
31PRKACB0.46370157
32NTRK30.45390927
33PRKACA0.44700495
34PRKACG0.44140265
35TXK0.43579129
36TIE10.42560506
37SRPK10.40959080
38CAMK2A0.40260550
39ABL10.40221719
40PLK40.39524935
41ERBB40.35192640
42ZAK0.33677801
43PINK10.31953698
44OXSR10.31723219
45PRKCG0.30387632
46PLK10.30289504
47PHKG20.27365196
48PHKG10.27365196
49WNK40.26616459
50EPHB20.26427389
51PRKCA0.25687885
52MAPK130.25308077
53CDK30.25097165
54MATK0.24316327
55MAPK140.24253674
56DYRK20.23509425
57FRK0.23482065
58DDR20.23137560
59GSK3B0.22399584
60LYN0.22186155
61PRKCB0.22050088
62GRK50.22037426
63CSNK1A10.21894436
64RPS6KA30.21858774
65KIT0.20758892
66TRIM280.20222000
67CHUK0.19123182
68STK390.18933032
69ADRBK10.17468125
70MAP2K70.16550438
71PRKG10.16268582
72PIK3CG0.16063203
73MAP3K40.16009205
74EPHA30.15848054
75CDK10.15819418
76PAK30.15679198
77PKN10.13687898
78FYN0.13457151
79WEE10.13348577
80RPS6KA50.13115332
81PASK0.12341347
82BMPR1B0.12204381
83PIK3CA0.11698489
84PRKCD0.11694006
85PRKCE0.11241164
86PRKDC0.10802148
87ABL20.09770767
88TGFBR10.09188728
89ERBB20.08923297
90PRKG20.08811412
91RPS6KA40.08718105
92CAMK10.08400977
93VRK10.08140529
94TEC0.08113113
95CAMK2G0.07934610
96AKT10.07695295
97IGF1R0.07692748
98LCK0.07522794
99MAPK90.07371170
100ITK0.06333792

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.20327180
2Sulfur relay system_Homo sapiens_hsa041223.88824024
3Sulfur metabolism_Homo sapiens_hsa009203.53382693
4Ovarian steroidogenesis_Homo sapiens_hsa049133.23713208
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20837343
6Linoleic acid metabolism_Homo sapiens_hsa005913.02459519
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.79818162
8Collecting duct acid secretion_Homo sapiens_hsa049662.52230449
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.49828995
10Bile secretion_Homo sapiens_hsa049762.27477354
11Vibrio cholerae infection_Homo sapiens_hsa051102.16683956
12Thyroid hormone synthesis_Homo sapiens_hsa049182.14591337
13Pancreatic secretion_Homo sapiens_hsa049722.13104548
14Fat digestion and absorption_Homo sapiens_hsa049752.12262815
15Cocaine addiction_Homo sapiens_hsa050302.09314776
16Salivary secretion_Homo sapiens_hsa049702.06652086
17Gastric acid secretion_Homo sapiens_hsa049712.04268789
18Synaptic vesicle cycle_Homo sapiens_hsa047212.00279630
19Circadian entrainment_Homo sapiens_hsa047131.94872612
20Taste transduction_Homo sapiens_hsa047421.93162350
21Glutamatergic synapse_Homo sapiens_hsa047241.84190170
22Insulin secretion_Homo sapiens_hsa049111.82646415
23Ether lipid metabolism_Homo sapiens_hsa005651.81248825
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79980089
25Morphine addiction_Homo sapiens_hsa050321.75038766
26GABAergic synapse_Homo sapiens_hsa047271.71660882
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.69354512
28Dilated cardiomyopathy_Homo sapiens_hsa054141.54908008
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52313584
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51309433
31Amphetamine addiction_Homo sapiens_hsa050311.49933957
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49560043
33Gap junction_Homo sapiens_hsa045401.48232697
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45015671
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35608316
36Melanogenesis_Homo sapiens_hsa049161.33885735
37Arachidonic acid metabolism_Homo sapiens_hsa005901.26711190
38GnRH signaling pathway_Homo sapiens_hsa049121.22213752
39Cholinergic synapse_Homo sapiens_hsa047251.18336273
40Oxytocin signaling pathway_Homo sapiens_hsa049211.17521822
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15700882
42Calcium signaling pathway_Homo sapiens_hsa040201.11927274
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04997094
44Estrogen signaling pathway_Homo sapiens_hsa049151.01582805
45Circadian rhythm_Homo sapiens_hsa047101.01513737
46Platelet activation_Homo sapiens_hsa046110.96173605
47Serotonergic synapse_Homo sapiens_hsa047260.90321929
48Dorso-ventral axis formation_Homo sapiens_hsa043200.88767215
49Parkinsons disease_Homo sapiens_hsa050120.87899801
50Pyruvate metabolism_Homo sapiens_hsa006200.82389381
51Oxidative phosphorylation_Homo sapiens_hsa001900.80174961
52RNA degradation_Homo sapiens_hsa030180.73056420
53Oocyte meiosis_Homo sapiens_hsa041140.71817154
54ECM-receptor interaction_Homo sapiens_hsa045120.65686341
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63319772
56Rheumatoid arthritis_Homo sapiens_hsa053230.62156580
57Chemokine signaling pathway_Homo sapiens_hsa040620.61921962
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.53430547
59cAMP signaling pathway_Homo sapiens_hsa040240.52202759
60Nicotine addiction_Homo sapiens_hsa050330.50551208
61Alcoholism_Homo sapiens_hsa050340.44446868
62Dopaminergic synapse_Homo sapiens_hsa047280.42281976
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38341564
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37679379
65Hedgehog signaling pathway_Homo sapiens_hsa043400.35907329
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.34934125
67Caffeine metabolism_Homo sapiens_hsa002320.33657480
68Purine metabolism_Homo sapiens_hsa002300.32971080
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.32279079
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.32125116
71Retinol metabolism_Homo sapiens_hsa008300.31934955
72Primary immunodeficiency_Homo sapiens_hsa053400.31564437
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31344336
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27332909
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.27156806
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20908706
77Rap1 signaling pathway_Homo sapiens_hsa040150.18993007
78Prion diseases_Homo sapiens_hsa050200.17551211
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17316503
80Staphylococcus aureus infection_Homo sapiens_hsa051500.16347087
81Chemical carcinogenesis_Homo sapiens_hsa052040.15211930
82Huntingtons disease_Homo sapiens_hsa050160.15065745
83Systemic lupus erythematosus_Homo sapiens_hsa053220.14515874
84Ras signaling pathway_Homo sapiens_hsa040140.14129974
85Glucagon signaling pathway_Homo sapiens_hsa049220.13238423
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13003663
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.12491358
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11438142
89Alzheimers disease_Homo sapiens_hsa050100.09706759
90Phototransduction_Homo sapiens_hsa047440.06686486
91Renin secretion_Homo sapiens_hsa049240.05391670
92Phagosome_Homo sapiens_hsa041450.04806419
93Nitrogen metabolism_Homo sapiens_hsa009100.04307428
94African trypanosomiasis_Homo sapiens_hsa051430.02870887
95HTLV-I infection_Homo sapiens_hsa051660.02754460
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.01697159
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.01241416
98Asthma_Homo sapiens_hsa053100.00236645
99Tuberculosis_Homo sapiens_hsa051520.00165952
100Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0147506

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