EIF3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.23753671
2nuclear pore organization (GO:0006999)5.96556117
3mitotic sister chromatid cohesion (GO:0007064)5.20497946
4pore complex assembly (GO:0046931)4.76044472
5DNA unwinding involved in DNA replication (GO:0006268)4.58693724
6protein localization to kinetochore (GO:0034501)4.35601364
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25297978
8mitotic nuclear envelope disassembly (GO:0007077)4.18410654
9regulation of RNA export from nucleus (GO:0046831)4.16736945
10heterochromatin organization (GO:0070828)3.95206841
11membrane disassembly (GO:0030397)3.95023788
12nuclear envelope disassembly (GO:0051081)3.95023788
13establishment of integrated proviral latency (GO:0075713)3.90367635
14pre-miRNA processing (GO:0031054)3.89651383
15regulation of spindle organization (GO:0090224)3.86839723
16mitotic metaphase plate congression (GO:0007080)3.80554772
17mitotic chromosome condensation (GO:0007076)3.78629615
18IMP biosynthetic process (GO:0006188)3.76637057
19regulation of mitotic spindle organization (GO:0060236)3.64140679
20DNA duplex unwinding (GO:0032508)3.63405453
21regulation of DNA endoreduplication (GO:0032875)3.62968918
22kinetochore organization (GO:0051383)3.62790050
23DNA geometric change (GO:0032392)3.62316964
24protein localization to chromosome, centromeric region (GO:0071459)3.58404282
25sister chromatid segregation (GO:0000819)3.57310487
26protein complex localization (GO:0031503)3.54264762
27folic acid-containing compound biosynthetic process (GO:0009396)3.49950431
28cellular protein complex localization (GO:0034629)3.46103378
29metaphase plate congression (GO:0051310)3.45570398
30histone H2B ubiquitination (GO:0033523)3.45377421
31positive regulation of chromosome segregation (GO:0051984)3.45326338
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.40170488
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40170488
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40170488
35negative regulation of histone methylation (GO:0031061)3.37740307
36ribosome assembly (GO:0042255)3.36624356
37spliceosomal tri-snRNP complex assembly (GO:0000244)3.31306457
38mitotic sister chromatid segregation (GO:0000070)3.28717508
39nucleobase biosynthetic process (GO:0046112)3.27682098
40regulation of sister chromatid cohesion (GO:0007063)3.27286592
41DNA replication-dependent nucleosome assembly (GO:0006335)3.26083906
42DNA replication-dependent nucleosome organization (GO:0034723)3.26083906
43IMP metabolic process (GO:0046040)3.25428648
44mRNA stabilization (GO:0048255)3.23607420
45RNA stabilization (GO:0043489)3.23607420
46regulation of histone H3-K9 methylation (GO:0051570)3.20677924
47regulation of translational fidelity (GO:0006450)3.18966976
48regulation of nucleobase-containing compound transport (GO:0032239)3.18737862
49chromatin assembly (GO:0031497)3.16248468
50DNA replication initiation (GO:0006270)3.16051759
51DNA packaging (GO:0006323)3.14656305
52nuclear envelope organization (GO:0006998)3.12659568
53dosage compensation (GO:0007549)3.06780909
54double-strand break repair via nonhomologous end joining (GO:0006303)3.06536123
55non-recombinational repair (GO:0000726)3.06536123
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06103337
57glucocorticoid receptor signaling pathway (GO:0042921)3.05926493
58regulation of centriole replication (GO:0046599)3.05726625
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02729781
60nucleosome disassembly (GO:0006337)3.02489447
61protein-DNA complex disassembly (GO:0032986)3.02489447
62negative regulation of DNA repair (GO:0045738)3.02366360
63NLS-bearing protein import into nucleus (GO:0006607)3.01996925
64regulation of centrosome cycle (GO:0046605)3.01128162
65protein export from nucleus (GO:0006611)2.99832703
66DNA conformation change (GO:0071103)2.99403633
67establishment of chromosome localization (GO:0051303)2.97440211
68DNA strand elongation involved in DNA replication (GO:0006271)2.95215149
69histone H2A monoubiquitination (GO:0035518)2.93060440
70DNA topological change (GO:0006265)2.91972156
71telomere maintenance via semi-conservative replication (GO:0032201)2.90064513
72chromatin assembly or disassembly (GO:0006333)2.89666955
73DNA replication checkpoint (GO:0000076)2.88372146
74purine nucleobase biosynthetic process (GO:0009113)2.87626051
75alternative mRNA splicing, via spliceosome (GO:0000380)2.87251205
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85462901
77regulation of posttranscriptional gene silencing (GO:0060147)2.83382455
78regulation of gene silencing by miRNA (GO:0060964)2.83382455
79regulation of gene silencing by RNA (GO:0060966)2.83382455
80ribosome biogenesis (GO:0042254)2.83209431
81DNA replication-independent nucleosome organization (GO:0034724)2.83130126
82DNA replication-independent nucleosome assembly (GO:0006336)2.83130126
83mRNA transport (GO:0051028)2.82955400
84monoubiquitinated protein deubiquitination (GO:0035520)2.82891002
85negative regulation of RNA splicing (GO:0033119)2.82122153
86positive regulation of SMAD protein import into nucleus (GO:0060391)2.80470196
87protein localization to chromosome (GO:0034502)2.80327283
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79473992
89DNA strand elongation (GO:0022616)2.79251117
90paraxial mesoderm development (GO:0048339)2.79158445
91regulation of chromosome segregation (GO:0051983)2.78911489
92meiotic chromosome segregation (GO:0045132)2.78552440
93negative regulation of mRNA metabolic process (GO:1903312)2.76913650
94attachment of spindle microtubules to kinetochore (GO:0008608)2.75884332
95kinetochore assembly (GO:0051382)2.75864019
96regulation of translational termination (GO:0006449)2.74785154
97spindle checkpoint (GO:0031577)2.74722456
98translesion synthesis (GO:0019985)2.73927753
99histone-serine phosphorylation (GO:0035404)2.73654827
100regulation of mRNA stability (GO:0043488)2.73310146
101cytoplasmic mRNA processing body assembly (GO:0033962)2.72994250
102regulation of centrosome duplication (GO:0010824)2.72969963
103chromatin remodeling at centromere (GO:0031055)2.72503258
104ATP-dependent chromatin remodeling (GO:0043044)2.72012624
105negative regulation of mRNA processing (GO:0050686)2.71430338
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71009938
107chromosome condensation (GO:0030261)2.69897323
108DNA synthesis involved in DNA repair (GO:0000731)2.69832686
109regulation of RNA stability (GO:0043487)2.68948404
110DNA ligation (GO:0006266)2.68613402
111sister chromatid cohesion (GO:0007062)2.68295336
112mitotic recombination (GO:0006312)2.67873808
113telomere maintenance via recombination (GO:0000722)2.67293966
114nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67113224
115* formation of translation preinitiation complex (GO:0001731)2.66862241
116regulation of DNA damage checkpoint (GO:2000001)2.66163424
117regulation of transcription from RNA polymerase I promoter (GO:0006356)2.66041340
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.63888736
119positive regulation of cell cycle checkpoint (GO:1901978)2.63720352
120establishment of viral latency (GO:0019043)2.63624285
121RNA splicing, via transesterification reactions (GO:0000375)2.63434474
122nucleic acid transport (GO:0050657)2.63367604
123RNA transport (GO:0050658)2.63367604
124establishment of RNA localization (GO:0051236)2.63367604
125spindle assembly checkpoint (GO:0071173)2.63307423
126mitotic spindle checkpoint (GO:0071174)2.62732282
127mRNA splicing, via spliceosome (GO:0000398)2.62371629
128RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.62371629
129regulation of histone H3-K27 methylation (GO:0061085)2.61447438
130positive regulation of DNA-templated transcription, elongation (GO:0032786)2.57378699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.20542143
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.12178488
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95599082
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60340129
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22306201
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.11547824
7AR_21909140_ChIP-Seq_LNCAP_Human2.71585833
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63707874
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53788230
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.47736803
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.45229536
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40035608
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31707755
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28124140
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24965780
16MYC_22102868_ChIP-Seq_BL_Human2.22897873
17E2F7_22180533_ChIP-Seq_HELA_Human10.2956735
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.99853674
19MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87884178
20XRN2_22483619_ChIP-Seq_HELA_Human1.78832155
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.74135646
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71023368
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70531587
24ELK1_19687146_ChIP-ChIP_HELA_Human1.69384644
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68533965
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68379705
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65544196
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64634434
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60263385
30KDM5A_27292631_Chip-Seq_BREAST_Human1.55818257
31* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54870995
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52871160
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.51846221
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50264556
35CIITA_25753668_ChIP-Seq_RAJI_Human1.48518832
36VDR_23849224_ChIP-Seq_CD4+_Human1.46399509
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.44851450
38ZNF263_19887448_ChIP-Seq_K562_Human1.43399299
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43134108
40TTF2_22483619_ChIP-Seq_HELA_Human1.40963799
41* TFEB_21752829_ChIP-Seq_HELA_Human1.36734860
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35866647
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35187749
44* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32725278
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32312152
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.31842785
47FOXP3_21729870_ChIP-Seq_TREG_Human1.31797217
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30655193
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27221909
50CHD1_26751641_Chip-Seq_LNCaP_Human1.26944477
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26781946
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25891462
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.24266572
54DCP1A_22483619_ChIP-Seq_HELA_Human1.24028800
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23605523
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21140390
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19276820
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19082723
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17108386
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16653912
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16601373
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16578321
63* GABP_19822575_ChIP-Seq_HepG2_Human1.16517565
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15771212
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15527312
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14846232
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14132945
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14089928
69CLOCK_20551151_ChIP-Seq_293T_Human1.13974564
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.13586965
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12708071
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07898906
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07493260
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06202454
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.06194869
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04840328
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04128927
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02831557
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02230951
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02130827
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01532628
82* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01432227
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01323757
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00798005
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00647400
86* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00533371
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00046699
88PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99062154
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99040492
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98991874
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98637003
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98637003
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98637003
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98406964
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97359581
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97080898
97UBF1/2_26484160_Chip-Seq_HMECs_Human0.96039541
98BRD4_25478319_ChIP-Seq_HGPS_Human0.95385777
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94729871
100* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94693952
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94504575
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94006639
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92428691
104ATF3_27146783_Chip-Seq_COLON_Human0.92027592
105* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91479278
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90372733
107VDR_21846776_ChIP-Seq_THP-1_Human0.89222196
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88794430
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88222050
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87873134
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87803105
112TCF7_22412390_ChIP-Seq_EML_Mouse0.87089491
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86444493
114* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86362839
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85861672
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84833274
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83511627
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.83340275
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83180470
120NCOR1_26117541_ChIP-Seq_K562_Human0.82393485
121* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82186779
122* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82186779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.41102575
2MP0010352_gastrointestinal_tract_polyps3.31023327
3MP0010094_abnormal_chromosome_stability3.29739217
4MP0008057_abnormal_DNA_replication3.21440772
5MP0004957_abnormal_blastocyst_morpholog3.11630503
6MP0003111_abnormal_nucleus_morphology3.09057352
7MP0003077_abnormal_cell_cycle2.87127001
8MP0003705_abnormal_hypodermis_morpholog2.68644219
9MP0005076_abnormal_cell_differentiation2.59509746
10MP0003123_paternal_imprinting2.33088261
11MP0001730_embryonic_growth_arrest2.23557480
12MP0010307_abnormal_tumor_latency2.17788119
13MP0008007_abnormal_cellular_replicative2.08688383
14MP0002009_preneoplasia2.05992359
15MP0000350_abnormal_cell_proliferation2.03313301
16MP0004197_abnormal_fetal_growth/weight/1.95078907
17MP0008058_abnormal_DNA_repair1.87844647
18MP0005380_embryogenesis_phenotype1.87117352
19MP0001672_abnormal_embryogenesis/_devel1.87117352
20MP0002396_abnormal_hematopoietic_system1.86819987
21MP0003984_embryonic_growth_retardation1.81804145
22MP0002088_abnormal_embryonic_growth/wei1.79915553
23MP0002084_abnormal_developmental_patter1.78999721
24MP0001697_abnormal_embryo_size1.74112116
25MP0009053_abnormal_anal_canal1.72889676
26MP0008932_abnormal_embryonic_tissue1.72199126
27MP0000537_abnormal_urethra_morphology1.71299647
28MP0003121_genomic_imprinting1.71061084
29MP0003566_abnormal_cell_adhesion1.70752608
30MP0008877_abnormal_DNA_methylation1.69942715
31MP0002086_abnormal_extraembryonic_tissu1.69452297
32MP0002796_impaired_skin_barrier1.66047252
33MP0003567_abnormal_fetal_cardiomyocyte1.65341824
34MP0002877_abnormal_melanocyte_morpholog1.64343305
35MP0002085_abnormal_embryonic_tissue1.59045753
36MP0004808_abnormal_hematopoietic_stem1.58130873
37MP0003890_abnormal_embryonic-extraembry1.56291653
38MP0004233_abnormal_muscle_weight1.48401137
39MP0002080_prenatal_lethality1.46209761
40MP0010234_abnormal_vibrissa_follicle1.39519468
41MP0010030_abnormal_orbit_morphology1.38176309
42MP0005501_abnormal_skin_physiology1.36341839
43MP0003941_abnormal_skin_development1.35014156
44MP0000733_abnormal_muscle_development1.34935807
45MP0001293_anophthalmia1.33731941
46MP0000579_abnormal_nail_morphology1.33570173
47MP0000569_abnormal_digit_pigmentation1.28489396
48MP0006054_spinal_hemorrhage1.27750326
49MP0008438_abnormal_cutaneous_collagen1.26893169
50MP0000762_abnormal_tongue_morphology1.25520449
51MP0009703_decreased_birth_body1.25089097
52MP0009672_abnormal_birth_weight1.25047221
53MP0005023_abnormal_wound_healing1.21437596
54MP0000428_abnormal_craniofacial_morphol1.20921775
55MP0009697_abnormal_copulation1.20339861
56MP0004264_abnormal_extraembryonic_tissu1.17223744
57MP0003937_abnormal_limbs/digits/tail_de1.16638798
58MP0005409_darkened_coat_color1.12341889
59MP0003315_abnormal_perineum_morphology1.09883591
60MP0002697_abnormal_eye_size1.08676289
61MP0003453_abnormal_keratinocyte_physiol1.07024983
62MP0005623_abnormal_meninges_morphology1.06154466
63MP0003115_abnormal_respiratory_system1.05789315
64MP0001849_ear_inflammation1.05472348
65MP0000432_abnormal_head_morphology1.03924840
66MP0000313_abnormal_cell_death1.03043126
67MP0000490_abnormal_crypts_of1.00582530
68MP0002925_abnormal_cardiovascular_devel1.00259018
69MP0003300_gastrointestinal_ulcer0.99783205
70MP0003935_abnormal_craniofacial_develop0.98679198
71MP0002092_abnormal_eye_morphology0.98445089
72MP0001915_intracranial_hemorrhage0.96909256
73MP0003119_abnormal_digestive_system0.95845932
74MP0005451_abnormal_body_composition0.94283386
75MP0005367_renal/urinary_system_phenotyp0.93983108
76MP0000516_abnormal_urinary_system0.93983108
77MP0002019_abnormal_tumor_incidence0.92835969
78MP0005275_abnormal_skin_tensile0.92726754
79MP0002111_abnormal_tail_morphology0.92574142
80MP0003786_premature_aging0.89861569
81MP0004272_abnormal_basement_membrane0.88802715
82MP0001216_abnormal_epidermal_layer0.87734572
83MP0009278_abnormal_bone_marrow0.86957614
84MP0003385_abnormal_body_wall0.86942049
85MP0003755_abnormal_palate_morphology0.86230068
86MP0004185_abnormal_adipocyte_glucose0.86214574
87MP0005666_abnormal_adipose_tissue0.85987321
88MP0010678_abnormal_skin_adnexa0.82437739
89MP0001286_abnormal_eye_development0.82279579
90MP0005621_abnormal_cell_physiology0.80014774
91MP0005397_hematopoietic_system_phenotyp0.78284423
92MP0001545_abnormal_hematopoietic_system0.78284423
93MP0003787_abnormal_imprinting0.77720541
94MP0004087_abnormal_muscle_fiber0.77440567
95MP0000266_abnormal_heart_morphology0.76758142
96MP0005257_abnormal_intraocular_pressure0.76594814
97MP0003943_abnormal_hepatobiliary_system0.75759056
98MP0000703_abnormal_thymus_morphology0.75409870
99MP0002233_abnormal_nose_morphology0.75403822
100MP0003950_abnormal_plasma_membrane0.75108851
101MP0000383_abnormal_hair_follicle0.75089473
102MP0005384_cellular_phenotype0.74718051
103MP0000358_abnormal_cell_content/0.74005410
104MP0002166_altered_tumor_susceptibility0.73623778
105MP0010630_abnormal_cardiac_muscle0.73466414
106MP0000566_synostosis0.73078436
107MP0002060_abnormal_skin_morphology0.72155509
108MP0003091_abnormal_cell_migration0.71580239
109MP0000627_abnormal_mammary_gland0.71405601
110MP0003861_abnormal_nervous_system0.70728759
111MP0001661_extended_life_span0.70233747
112MP0002006_tumorigenesis0.69974657
113MP0000377_abnormal_hair_follicle0.69439310
114MP0001727_abnormal_embryo_implantation0.68600814
115MP0002114_abnormal_axial_skeleton0.68560849
116MP0002269_muscular_atrophy0.68258131
117MP0001299_abnormal_eye_distance/0.68016810
118MP0005503_abnormal_tendon_morphology0.68004490
119MP0001243_abnormal_dermal_layer0.67813492
120MP0003448_altered_tumor_morphology0.67534587
121MP0001784_abnormal_fluid_regulation0.65873584
122MP0003942_abnormal_urinary_system0.64541604
123MP0003221_abnormal_cardiomyocyte_apopto0.64297554
124MP0000858_altered_metastatic_potential0.64016524
125MP0005187_abnormal_penis_morphology0.60968128
126MP0000750_abnormal_muscle_regeneration0.60962087

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.98108530
2Deviation of the thumb (HP:0009603)3.33544164
3Proximal placement of thumb (HP:0009623)3.21039294
4Ependymoma (HP:0002888)3.08466667
5Hyperacusis (HP:0010780)2.88821245
6Colon cancer (HP:0003003)2.88803391
7Vertebral arch anomaly (HP:0008438)2.85999403
8Increased nuchal translucency (HP:0010880)2.78413292
9Short 4th metacarpal (HP:0010044)2.75811689
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75811689
11Selective tooth agenesis (HP:0001592)2.73062177
12Long eyelashes (HP:0000527)2.69696329
13Medulloblastoma (HP:0002885)2.58090584
14Multiple enchondromatosis (HP:0005701)2.57384766
15Chromsome breakage (HP:0040012)2.52642264
16Biliary tract neoplasm (HP:0100574)2.52225481
17Abnormality of the astrocytes (HP:0100707)2.51257579
18Astrocytoma (HP:0009592)2.51257579
19Insomnia (HP:0100785)2.43173951
20Ankyloglossia (HP:0010296)2.38943660
21Urethral obstruction (HP:0000796)2.38848097
22Syringomyelia (HP:0003396)2.37877295
23Spinal cord lesions (HP:0100561)2.37877295
24Rectal prolapse (HP:0002035)2.36262919
25Abnormality of the fingertips (HP:0001211)2.34848037
26Ectopic kidney (HP:0000086)2.30287835
27Asymmetry of the thorax (HP:0001555)2.27827012
28Abnormality of chromosome stability (HP:0003220)2.27696179
29Cortical dysplasia (HP:0002539)2.23347604
30Degeneration of anterior horn cells (HP:0002398)2.22790583
31Abnormality of the anterior horn cell (HP:0006802)2.22790583
32Nephroblastoma (Wilms tumor) (HP:0002667)2.21554841
33Shallow orbits (HP:0000586)2.20266911
34Deep philtrum (HP:0002002)2.20234767
35Glioma (HP:0009733)2.19938915
36Ankle contracture (HP:0006466)2.18531985
37Insidious onset (HP:0003587)2.17942288
38Termporal pattern (HP:0011008)2.17942288
39Birth length less than 3rd percentile (HP:0003561)2.17840335
40Pelvic girdle muscle weakness (HP:0003749)2.17155899
41Gastrointestinal carcinoma (HP:0002672)2.15886484
42Malignant gastrointestinal tract tumors (HP:0006749)2.15886484
43Atresia of the external auditory canal (HP:0000413)2.12479197
44Atrophic scars (HP:0001075)2.10163974
45Progressive external ophthalmoplegia (HP:0000590)2.09843922
46Broad thumb (HP:0011304)2.08908006
47Ulnar bowing (HP:0003031)2.08331894
48Rhabdomyosarcoma (HP:0002859)2.08029258
49Spastic diplegia (HP:0001264)2.05633842
50High anterior hairline (HP:0009890)2.05052284
51Embryonal renal neoplasm (HP:0011794)2.04966176
52Prominent nose (HP:0000448)2.04856954
53Overriding aorta (HP:0002623)2.03538618
54Abnormality of the labia minora (HP:0012880)2.02728435
55Progressive muscle weakness (HP:0003323)2.00760929
56Increased density of long bones (HP:0006392)1.99583049
57Protrusio acetabuli (HP:0003179)1.98839399
58Overlapping toe (HP:0001845)1.97972243
59Low anterior hairline (HP:0000294)1.97524016
60Missing ribs (HP:0000921)1.97440816
61Blepharitis (HP:0000498)1.97116766
62Spinal muscular atrophy (HP:0007269)1.97068828
63Dysmetric saccades (HP:0000641)1.96719431
64Abnormal number of incisors (HP:0011064)1.95436349
65Agnosia (HP:0010524)1.94475877
66Abnormality of oral frenula (HP:0000190)1.94275491
67Neoplasm of the oral cavity (HP:0100649)1.94264288
68Papillary thyroid carcinoma (HP:0002895)1.94238359
69Abnormality of the 4th metacarpal (HP:0010012)1.92997827
70Aplasia/Hypoplasia of the sternum (HP:0006714)1.92244655
71Abnormality of the calcaneus (HP:0008364)1.90260607
72Calcaneovalgus deformity (HP:0001848)1.89264203
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89155341
74Patellar aplasia (HP:0006443)1.88965270
75High pitched voice (HP:0001620)1.88297172
76Natal tooth (HP:0000695)1.87295082
77Breech presentation (HP:0001623)1.86051369
78Subacute progressive viral hepatitis (HP:0006572)1.85917372
79Trismus (HP:0000211)1.85902249
80Uterine neoplasm (HP:0010784)1.84430205
81Elfin facies (HP:0004428)1.82059036
82Skull defect (HP:0001362)1.80879047
83Neonatal short-limb short stature (HP:0008921)1.79592335
84Obsessive-compulsive behavior (HP:0000722)1.78982010
85Renal duplication (HP:0000075)1.78928169
86Impulsivity (HP:0100710)1.78918240
87Aplasia cutis congenita (HP:0001057)1.78819526
88Supernumerary ribs (HP:0005815)1.77632585
89Myelodysplasia (HP:0002863)1.77335813
90Advanced eruption of teeth (HP:0006288)1.76967565
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.76713963
92Cerebral aneurysm (HP:0004944)1.76074087
93Aplasia/Hypoplasia of the patella (HP:0006498)1.76058473
94Skin tags (HP:0010609)1.74819772
95Truncal obesity (HP:0001956)1.74338723
96Acute myeloid leukemia (HP:0004808)1.74293461
97Cutaneous melanoma (HP:0012056)1.73944450
98Abnormality of the hip-girdle musculature (HP:0001445)1.73556059
99Abnormality of the musculature of the pelvis (HP:0001469)1.73556059
100Meckel diverticulum (HP:0002245)1.73477168
101Renovascular hypertension (HP:0100817)1.73211683
102Basal cell carcinoma (HP:0002671)1.72787879
103Long palpebral fissure (HP:0000637)1.72137289
104Facial hemangioma (HP:0000329)1.72042506
105Cutis marmorata (HP:0000965)1.72017270
106Neoplasm of striated muscle (HP:0009728)1.71417989
107Sparse lateral eyebrow (HP:0005338)1.71132141
108Abnormal biliary tract morphology (HP:0012440)1.71055807
109Limited elbow extension (HP:0001377)1.70973672
110Broad phalanges of the hand (HP:0009768)1.70952783
111Neoplasm of the pancreas (HP:0002894)1.70834022
112Leiomyosarcoma (HP:0100243)1.70824845
113Uterine leiomyosarcoma (HP:0002891)1.70824845
114Right ventricular cardiomyopathy (HP:0011663)1.69977105
115Sandal gap (HP:0001852)1.69841902
116Cervical subluxation (HP:0003308)1.69735013
117Cafe-au-lait spot (HP:0000957)1.69085836
118Mitral valve prolapse (HP:0001634)1.68966726
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68493364
120Fragile skin (HP:0001030)1.68328329
121Pseudobulbar signs (HP:0002200)1.68257249
122Cubitus valgus (HP:0002967)1.68153075
123Short humerus (HP:0005792)1.68117581
124Arnold-Chiari malformation (HP:0002308)1.67639393
125Hypoplastic labia majora (HP:0000059)1.67345331
126Abnormality of the salivary glands (HP:0010286)1.67105464
127Abnormality of chromosome segregation (HP:0002916)1.67101141
128Glossoptosis (HP:0000162)1.66865003
129Progressive hearing impairment (HP:0001730)1.65576823
130Shoulder girdle muscle weakness (HP:0003547)1.65506245
131Aplasia/hypoplasia of the humerus (HP:0006507)1.65457578
132Abnormality of the preputium (HP:0100587)1.64673251
133Trigonocephaly (HP:0000243)1.64005029
134Preauricular skin tag (HP:0000384)1.63879896
135Heterotopia (HP:0002282)1.63735240
136Broad palm (HP:0001169)1.62558788
137Supernumerary bones of the axial skeleton (HP:0009144)1.62194980
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.60909709
139Osteolytic defects of the hand bones (HP:0009699)1.60909709
140Back pain (HP:0003418)1.60800842
141Hypoplastic toenails (HP:0001800)1.60571638
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.60067340
143Transitional cell carcinoma of the bladder (HP:0006740)1.59680773
144Shawl scrotum (HP:0000049)1.58966888
145Intestinal malrotation (HP:0002566)1.58729673
146Ovarian neoplasm (HP:0100615)1.58512388
147Radioulnar synostosis (HP:0002974)1.58275590
148Premature rupture of membranes (HP:0001788)1.58217916
149Abnormality of the ileum (HP:0001549)1.57009312
150Bowel diverticulosis (HP:0005222)1.56799915
151Squamous cell carcinoma (HP:0002860)1.56576243
152Increased connective tissue (HP:0009025)1.55685888
153Abnormal foot bone ossification (HP:0010675)1.53599485
154Deep palmar crease (HP:0006191)1.53033881
155Bladder diverticulum (HP:0000015)1.52153880
156Deformed tarsal bones (HP:0008119)1.51909852
157Choanal atresia (HP:0000453)1.51453878
158Cystic hygroma (HP:0000476)1.51240082
159Arterial tortuosity (HP:0005116)1.50403177
160Hypopigmentation of the fundus (HP:0007894)1.49932054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.28719216
2CDK124.12649814
3NEK22.52932112
4LATS12.41916267
5WEE12.37040057
6SMG12.30990457
7EEF2K2.30905123
8TSSK62.25074525
9MKNK12.03328733
10TTK1.99203694
11MST1R1.96467485
12BRD41.95337969
13PASK1.88219455
14PKN21.82741855
15PLK31.76182055
16BRSK21.76056564
17RPS6KA41.75891860
18STK31.72399987
19SCYL21.65423155
20SRPK11.65338612
21STK101.62928647
22MAP3K101.62212823
23ATR1.62183299
24NEK11.61645894
25CDK61.60956409
26EIF2AK11.60691677
27ICK1.59856536
28RPS6KB21.58907492
29EPHA21.55414367
30AURKB1.52349234
31TAF11.51112173
32TNIK1.48637369
33CDK41.48488263
34CHEK11.46981207
35TTN1.46138404
36ALK1.46002752
37PLK41.42742768
38PLK11.42007593
39MKNK21.39403439
40MTOR1.37082463
41PBK1.33490075
42CDK71.31492014
43BUB11.30403202
44TRIB31.30092004
45PNCK1.28583741
46MAP3K81.25988971
47ACVR1B1.22678353
48ATM1.20652924
49TGFBR11.18532539
50CHEK21.16438762
51MST41.12645903
52STK41.07169405
53PAK41.05923616
54PTK61.03785353
55PAK21.03380340
56CDK21.01918349
57NUAK11.01357793
58PDGFRA0.98262284
59FGFR10.97697376
60CAMK1D0.97380016
61PRPF4B0.96301591
62STK240.94703359
63MELK0.92746750
64LRRK20.90164159
65EIF2AK30.89045377
66MAP3K90.87428069
67FRK0.85575141
68CLK10.84941106
69ERBB40.82171015
70NTRK10.80762968
71PIM10.80278269
72FGFR40.78715702
73CDK10.78124659
74ERBB30.77771853
75EIF2AK20.76588453
76LATS20.72536313
77MAP2K30.71934181
78CSNK1E0.70242068
79WNK10.70037862
80NEK90.69640275
81CAMK1G0.68865746
82NME20.67567944
83BRSK10.64801110
84MAP3K140.64713169
85YES10.63628681
86PRKDC0.63244925
87PDGFRB0.63243421
88TRPM70.63028659
89BMX0.62505957
90ZAK0.61836200
91STK38L0.61506961
92CHUK0.61445829
93CSNK2A20.61055507
94DMPK0.59715800
95DDR20.59273261
96MET0.58082823
97CSNK1D0.56147893
98MAPK140.54174483
99PDK20.53509513
100MAP3K30.52497232
101AURKA0.50366387
102RIPK10.48965188
103MARK30.47069167
104MAPK100.46793401
105DYRK30.46615789
106FLT30.45497032
107CDK90.45424719
108FGFR30.43576433
109CDK30.42632810
110PTK20.42280573
111MAPK10.42018639
112JAK30.39683254
113KSR10.39224839
114AKT10.38756433
115CSNK2A10.38259745
116RPS6KB10.37356392
117GSK3B0.36635487
118AKT20.36385102
119SIK10.35997055
120BRAF0.34867388
121CDK80.33887050
122MOS0.33618756
123MAP3K130.33293624
124IRAK30.32395542
125CSNK1A1L0.29857888
126PAK10.29513134
127MAPKAPK20.29161313
128AKT30.28782542

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.33459100
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22526202
3* RNA transport_Homo sapiens_hsa030133.22429270
4Mismatch repair_Homo sapiens_hsa034303.06933515
5Spliceosome_Homo sapiens_hsa030402.92731490
6Cell cycle_Homo sapiens_hsa041102.91633328
7One carbon pool by folate_Homo sapiens_hsa006702.55847089
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45508962
9mRNA surveillance pathway_Homo sapiens_hsa030152.29358479
10Non-homologous end-joining_Homo sapiens_hsa034502.15636157
11Homologous recombination_Homo sapiens_hsa034402.03403354
12Nucleotide excision repair_Homo sapiens_hsa034202.00444034
13Base excision repair_Homo sapiens_hsa034102.00168673
14RNA degradation_Homo sapiens_hsa030181.79327671
15p53 signaling pathway_Homo sapiens_hsa041151.75991458
16Fanconi anemia pathway_Homo sapiens_hsa034601.73921559
17MicroRNAs in cancer_Homo sapiens_hsa052061.71050244
18Adherens junction_Homo sapiens_hsa045201.57670271
19Small cell lung cancer_Homo sapiens_hsa052221.53876654
20RNA polymerase_Homo sapiens_hsa030201.47099681
21Viral carcinogenesis_Homo sapiens_hsa052031.44616485
22Antigen processing and presentation_Homo sapiens_hsa046121.41241959
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39389745
24Chronic myeloid leukemia_Homo sapiens_hsa052201.29871434
25Basal transcription factors_Homo sapiens_hsa030221.28917519
26Biosynthesis of amino acids_Homo sapiens_hsa012301.26966577
27HTLV-I infection_Homo sapiens_hsa051661.24795007
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23505622
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23307057
30Hippo signaling pathway_Homo sapiens_hsa043901.22399600
31Thyroid cancer_Homo sapiens_hsa052161.22349156
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22226567
33TGF-beta signaling pathway_Homo sapiens_hsa043501.19298740
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17091363
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13141494
36Proteoglycans in cancer_Homo sapiens_hsa052051.12850710
37Lysine degradation_Homo sapiens_hsa003101.12727554
38Prostate cancer_Homo sapiens_hsa052151.09859791
39Herpes simplex infection_Homo sapiens_hsa051681.09511951
40Viral myocarditis_Homo sapiens_hsa054161.05388649
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03148397
42Pyrimidine metabolism_Homo sapiens_hsa002401.02513515
43mTOR signaling pathway_Homo sapiens_hsa041501.02109413
44Basal cell carcinoma_Homo sapiens_hsa052171.00496410
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99907640
46Oocyte meiosis_Homo sapiens_hsa041140.99116948
47Colorectal cancer_Homo sapiens_hsa052100.98460885
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96908579
49Ribosome_Homo sapiens_hsa030100.95391397
50ECM-receptor interaction_Homo sapiens_hsa045120.95317927
51Focal adhesion_Homo sapiens_hsa045100.94637192
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.92370061
53Bladder cancer_Homo sapiens_hsa052190.92045770
54Pentose phosphate pathway_Homo sapiens_hsa000300.87378108
55Carbon metabolism_Homo sapiens_hsa012000.83464914
56Notch signaling pathway_Homo sapiens_hsa043300.80987320
57Pancreatic cancer_Homo sapiens_hsa052120.80650411
58Legionellosis_Homo sapiens_hsa051340.80292092
59ErbB signaling pathway_Homo sapiens_hsa040120.80029819
60Selenocompound metabolism_Homo sapiens_hsa004500.79924843
61Proteasome_Homo sapiens_hsa030500.79308265
62Hepatitis B_Homo sapiens_hsa051610.79008169
63Pathways in cancer_Homo sapiens_hsa052000.78665781
64Systemic lupus erythematosus_Homo sapiens_hsa053220.78383914
65Endometrial cancer_Homo sapiens_hsa052130.77645211
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.77348331
67Vitamin B6 metabolism_Homo sapiens_hsa007500.76598953
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76026580
69Tight junction_Homo sapiens_hsa045300.74579681
70Pyruvate metabolism_Homo sapiens_hsa006200.73654848
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.71063350
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.70979944
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70863522
74Apoptosis_Homo sapiens_hsa042100.70726686
75Insulin signaling pathway_Homo sapiens_hsa049100.69902477
76Non-small cell lung cancer_Homo sapiens_hsa052230.69049209
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68503168
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68107668
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67276273
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65284042
81Hedgehog signaling pathway_Homo sapiens_hsa043400.63134235
82HIF-1 signaling pathway_Homo sapiens_hsa040660.62827534
83Melanoma_Homo sapiens_hsa052180.62245920
84FoxO signaling pathway_Homo sapiens_hsa040680.62216949
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61794053
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60864315
87Toxoplasmosis_Homo sapiens_hsa051450.60537219
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60351086
89Measles_Homo sapiens_hsa051620.59283492
90Acute myeloid leukemia_Homo sapiens_hsa052210.58620963
91Renal cell carcinoma_Homo sapiens_hsa052110.58079558
92Shigellosis_Homo sapiens_hsa051310.55882566
93Wnt signaling pathway_Homo sapiens_hsa043100.55561672
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55504039
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54258965
96Fatty acid biosynthesis_Homo sapiens_hsa000610.53285443
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.52502033
98Influenza A_Homo sapiens_hsa051640.51214515
99Amoebiasis_Homo sapiens_hsa051460.46295466
100Leishmaniasis_Homo sapiens_hsa051400.45778040
101Glioma_Homo sapiens_hsa052140.45606037
102N-Glycan biosynthesis_Homo sapiens_hsa005100.41522733
103Inositol phosphate metabolism_Homo sapiens_hsa005620.41496447
104Fructose and mannose metabolism_Homo sapiens_hsa000510.41361622
105Estrogen signaling pathway_Homo sapiens_hsa049150.41110770
106TNF signaling pathway_Homo sapiens_hsa046680.40711053
107Glucagon signaling pathway_Homo sapiens_hsa049220.39860604
108Platelet activation_Homo sapiens_hsa046110.37313105
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.36505522
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35613596
111Renin-angiotensin system_Homo sapiens_hsa046140.35161336
112Hematopoietic cell lineage_Homo sapiens_hsa046400.34807115
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34721341
114Purine metabolism_Homo sapiens_hsa002300.34687233
115Insulin resistance_Homo sapiens_hsa049310.34631296
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33407833
117T cell receptor signaling pathway_Homo sapiens_hsa046600.32067927
118Prolactin signaling pathway_Homo sapiens_hsa049170.30745464
119AMPK signaling pathway_Homo sapiens_hsa041520.30529189
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30520112

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