EIF3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.29287970
2nuclear pore complex assembly (GO:0051292)5.15518543
3Golgi transport vesicle coating (GO:0048200)5.05921401
4COPI coating of Golgi vesicle (GO:0048205)5.05921401
5DNA unwinding involved in DNA replication (GO:0006268)4.77836840
6proline biosynthetic process (GO:0006561)4.58092016
7folic acid-containing compound biosynthetic process (GO:0009396)4.56788426
8protein localization to kinetochore (GO:0034501)4.52656625
9mitotic nuclear envelope disassembly (GO:0007077)4.43493092
10ribosome assembly (GO:0042255)4.18296968
11nuclear envelope disassembly (GO:0051081)4.17191389
12membrane disassembly (GO:0030397)4.17191389
13nucleobase biosynthetic process (GO:0046112)4.15681531
14* formation of translation preinitiation complex (GO:0001731)4.10138607
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09784926
16mitotic metaphase plate congression (GO:0007080)4.05972286
17maturation of SSU-rRNA (GO:0030490)4.05439536
18heterochromatin organization (GO:0070828)3.99605528
19regulation of translational fidelity (GO:0006450)3.95601455
20regulation of spindle organization (GO:0090224)3.94148101
21IMP biosynthetic process (GO:0006188)3.92100588
22pore complex assembly (GO:0046931)3.89967942
23DNA replication-dependent nucleosome assembly (GO:0006335)3.88937705
24DNA replication-dependent nucleosome organization (GO:0034723)3.88937705
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81965518
26protein localization to chromosome, centromeric region (GO:0071459)3.76853817
27mitotic sister chromatid segregation (GO:0000070)3.74912862
28DNA replication initiation (GO:0006270)3.71382303
29sister chromatid segregation (GO:0000819)3.71340465
30purine nucleobase biosynthetic process (GO:0009113)3.69122788
31regulation of mitotic spindle organization (GO:0060236)3.69035192
32positive regulation of chromosome segregation (GO:0051984)3.67394495
33regulation of translational termination (GO:0006449)3.64809368
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57344064
35histone arginine methylation (GO:0034969)3.54361259
36regulation of RNA export from nucleus (GO:0046831)3.52897304
37protein complex localization (GO:0031503)3.51481616
38protein retention in ER lumen (GO:0006621)3.51253403
39mitotic chromosome condensation (GO:0007076)3.50821805
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.50020102
41metaphase plate congression (GO:0051310)3.49609768
42pre-miRNA processing (GO:0031054)3.48062034
43mitotic sister chromatid cohesion (GO:0007064)3.43437988
44* translational initiation (GO:0006413)3.43301453
45DNA duplex unwinding (GO:0032508)3.43174075
46ribosomal large subunit biogenesis (GO:0042273)3.42402263
47regulation of posttranscriptional gene silencing (GO:0060147)3.42271280
48regulation of gene silencing by miRNA (GO:0060964)3.42271280
49regulation of gene silencing by RNA (GO:0060966)3.42271280
50DNA strand elongation involved in DNA replication (GO:0006271)3.40660425
51DNA geometric change (GO:0032392)3.40422556
52IMP metabolic process (GO:0046040)3.39828635
53protein-DNA complex disassembly (GO:0032986)3.39461740
54nucleosome disassembly (GO:0006337)3.39461740
55nuclear envelope organization (GO:0006998)3.38810266
56ribosome biogenesis (GO:0042254)3.37814275
57translational termination (GO:0006415)3.37722685
58viral transcription (GO:0019083)3.33036530
59chaperone-mediated protein complex assembly (GO:0051131)3.32551273
60proline metabolic process (GO:0006560)3.29817798
61establishment of integrated proviral latency (GO:0075713)3.29696234
62negative regulation of histone methylation (GO:0031061)3.23418491
63DNA replication checkpoint (GO:0000076)3.22489361
64ribonucleoprotein complex biogenesis (GO:0022613)3.21094423
65pentose-phosphate shunt (GO:0006098)3.21034920
66chromatin assembly (GO:0031497)3.20669920
67DNA strand elongation (GO:0022616)3.18229283
68negative regulation of mRNA processing (GO:0050686)3.17981555
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17265332
70peptidyl-arginine omega-N-methylation (GO:0035247)3.16253802
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14529237
72regulation of histone H3-K9 methylation (GO:0051570)3.14150818
73negative regulation of cell size (GO:0045792)3.13077268
74regulation of chromosome segregation (GO:0051983)3.11878285
75cellular protein complex localization (GO:0034629)3.10490841
76translational elongation (GO:0006414)3.08155983
77regulation of nucleobase-containing compound transport (GO:0032239)3.06281133
78DNA topological change (GO:0006265)3.05890434
79adherens junction assembly (GO:0034333)3.05579477
80desmosome organization (GO:0002934)3.05375930
81histone H2A monoubiquitination (GO:0035518)3.05102424
82L-serine metabolic process (GO:0006563)3.04931967
83spliceosomal tri-snRNP complex assembly (GO:0000244)3.04530633
84negative regulation of mRNA metabolic process (GO:1903312)3.01092131
85NADPH regeneration (GO:0006740)3.00372401
86protein localization to chromosome (GO:0034502)3.00147649
87regulation of centrosome cycle (GO:0046605)3.00104352
88protein export from nucleus (GO:0006611)3.00024047
89establishment of chromosome localization (GO:0051303)2.99152043
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99006593
91regulation of sister chromatid cohesion (GO:0007063)2.98533124
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94651170
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.94651170
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94651170
95spindle checkpoint (GO:0031577)2.94636528
96focal adhesion assembly (GO:0048041)2.93946615
97cell-substrate adherens junction assembly (GO:0007045)2.93946615
98mitotic spindle checkpoint (GO:0071174)2.93472193
99telomere maintenance via semi-conservative replication (GO:0032201)2.91716184
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91165973
101ribosomal small subunit assembly (GO:0000028)2.89433754
102negative regulation of chromosome segregation (GO:0051985)2.89094865
103rRNA processing (GO:0006364)2.88836464
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88725162
105mRNA stabilization (GO:0048255)2.86499913
106RNA stabilization (GO:0043489)2.86499913
107mRNA splicing, via spliceosome (GO:0000398)2.86205530
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86205530
109RNA splicing, via transesterification reactions (GO:0000375)2.85657346
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85552636
111glucose catabolic process (GO:0006007)2.85219998
112chromatin assembly or disassembly (GO:0006333)2.85099453
113negative regulation of DNA repair (GO:0045738)2.84694440
114ribosomal small subunit biogenesis (GO:0042274)2.83992763
115protein maturation by protein folding (GO:0022417)2.82715886
116negative regulation of sister chromatid segregation (GO:0033046)2.82469737
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.82469737
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82469737
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82469737
120mitotic spindle assembly checkpoint (GO:0007094)2.82333164
121maternal placenta development (GO:0001893)2.81966128
122rRNA metabolic process (GO:0016072)2.81352851
123spindle assembly checkpoint (GO:0071173)2.81087319
124peptidyl-arginine N-methylation (GO:0035246)2.80759536
125peptidyl-arginine methylation (GO:0018216)2.80759536
126attachment of spindle microtubules to kinetochore (GO:0008608)2.80708982
127alternative mRNA splicing, via spliceosome (GO:0000380)2.80108329
128folic acid metabolic process (GO:0046655)2.79487390
129chromosome condensation (GO:0030261)2.79401336
130histone-serine phosphorylation (GO:0035404)2.79094916
131DNA conformation change (GO:0071103)2.78454936
132spliceosomal snRNP assembly (GO:0000387)2.78122240
133regulation of centriole replication (GO:0046599)2.77798964
134cellular response to epidermal growth factor stimulus (GO:0071364)2.77316458
135kinetochore organization (GO:0051383)2.77315713
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77171858
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.77109614
138rRNA transcription (GO:0009303)2.76595397
139activation of Rac GTPase activity (GO:0032863)2.75734993
140tRNA aminoacylation for protein translation (GO:0006418)2.73297150
141glucose 6-phosphate metabolic process (GO:0051156)2.72997700
142negative regulation of RNA splicing (GO:0033119)2.72511023
143hemidesmosome assembly (GO:0031581)2.71108098
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62869725
145cell-substrate junction assembly (GO:0007044)2.61550773
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59673287
147peptidyl-lysine dimethylation (GO:0018027)2.59570522
148positive regulation of nuclease activity (GO:0032075)2.58929481
149amino acid activation (GO:0043038)2.56146261
150tRNA aminoacylation (GO:0043039)2.56146261
151apoptotic process involved in morphogenesis (GO:0060561)2.55724104
152snRNA metabolic process (GO:0016073)2.53406852
153regulation of histone H3-K27 methylation (GO:0061085)2.48040049
154regulation of translational elongation (GO:0006448)2.47538755
155epithelial cell-cell adhesion (GO:0090136)2.46808277
156cellular hyperosmotic response (GO:0071474)2.45783884
157basement membrane organization (GO:0071711)2.45523906
158positive regulation of DNA-dependent DNA replication (GO:2000105)2.45024895
159establishment of apical/basal cell polarity (GO:0035089)2.43216456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30847621
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.68571870
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.25289002
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47601841
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44945961
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27849750
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.96827455
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92110963
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67000062
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49975295
11AR_21909140_ChIP-Seq_LNCAP_Human2.46281876
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.40935166
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38812699
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37042298
15XRN2_22483619_ChIP-Seq_HELA_Human2.33857414
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28881039
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.28599658
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27285815
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27230109
20MYC_22102868_ChIP-Seq_BL_Human2.21838284
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.00851970
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94575609
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.92089926
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84754381
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83764160
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82825176
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81974890
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79817140
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77969307
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76782524
31RACK7_27058665_Chip-Seq_MCF-7_Human1.75604206
32VDR_23849224_ChIP-Seq_CD4+_Human1.73497308
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72938773
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70071101
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69949254
36KDM5A_27292631_Chip-Seq_BREAST_Human1.68704426
37TTF2_22483619_ChIP-Seq_HELA_Human1.68487063
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.66934110
39LXR_22292898_ChIP-Seq_THP-1_Human1.66825800
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65654827
41DCP1A_22483619_ChIP-Seq_HELA_Human1.65046611
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60205447
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59652877
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57022001
45GABP_19822575_ChIP-Seq_HepG2_Human1.56903832
46FOXP3_21729870_ChIP-Seq_TREG_Human1.56458255
47CIITA_25753668_ChIP-Seq_RAJI_Human1.54940887
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49883112
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49309058
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48747712
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47856196
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45949366
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44139667
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43782467
55ZNF263_19887448_ChIP-Seq_K562_Human1.43607176
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43418947
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.42384705
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41307496
59ELK1_19687146_ChIP-ChIP_HELA_Human1.40633454
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38235032
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37197080
62TFEB_21752829_ChIP-Seq_HELA_Human1.33016509
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32592049
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32049370
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25749203
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24397562
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.23630402
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22789839
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22655868
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22655868
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22655868
72TCF7_22412390_ChIP-Seq_EML_Mouse1.22474973
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21940093
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21664973
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21631696
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21138781
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20408452
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20199723
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19877760
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19492495
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18620162
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.17739319
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16929850
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15806393
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15711739
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15552508
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15535181
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15470192
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.15190319
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14976229
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.14757870
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14092618
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12820388
94ATF3_27146783_Chip-Seq_COLON_Human1.11486660
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10314862
96P68_20966046_ChIP-Seq_HELA_Human1.10232501
97CHD1_26751641_Chip-Seq_LNCaP_Human1.09535817
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09277337
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08574190
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07784884
101NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07165531
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.07032576
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06394693
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06337771
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05973844
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05125086
107VDR_21846776_ChIP-Seq_THP-1_Human1.04869988
108KDM2B_26808549_Chip-Seq_DND41_Human1.04375501
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.03935077
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03922886
111KDM2B_26808549_Chip-Seq_K562_Human1.03817956
112* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03571692
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02959324
114* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02702025
115NCOR1_26117541_ChIP-Seq_K562_Human1.02461133
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01530172
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00687021
118ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00653571
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00177506
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99318775
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99264844
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99179001
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98879607
124CLOCK_20551151_ChIP-Seq_293T_Human0.96764034
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96696793
126SMC4_20622854_ChIP-Seq_HELA_Human0.96662369
127YY1_21170310_ChIP-Seq_MESCs_Mouse0.93824902
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93575310
129* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93506704
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93310422
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92710342
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92568134
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92234209
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92219757
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91591255
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91457723
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88315606
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87347750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44312260
2MP0004957_abnormal_blastocyst_morpholog3.97506081
3MP0003111_abnormal_nucleus_morphology3.82951422
4MP0010094_abnormal_chromosome_stability3.46471760
5MP0003077_abnormal_cell_cycle3.32333888
6MP0010352_gastrointestinal_tract_polyps3.29517208
7MP0001730_embryonic_growth_arrest2.83220466
8MP0003705_abnormal_hypodermis_morpholog2.75532225
9MP0008057_abnormal_DNA_replication2.75326750
10MP0003123_paternal_imprinting2.61198687
11MP0005076_abnormal_cell_differentiation2.44513186
12MP0000350_abnormal_cell_proliferation2.33854809
13MP0008932_abnormal_embryonic_tissue2.32785696
14MP0010307_abnormal_tumor_latency2.30059654
15MP0008007_abnormal_cellular_replicative2.25108548
16MP0002796_impaired_skin_barrier2.22847742
17MP0005451_abnormal_body_composition2.10060137
18MP0005380_embryogenesis_phenotype2.07390755
19MP0001672_abnormal_embryogenesis/_devel2.07390755
20MP0001697_abnormal_embryo_size1.98291133
21MP0002084_abnormal_developmental_patter1.97053711
22MP0004197_abnormal_fetal_growth/weight/1.96359119
23MP0000537_abnormal_urethra_morphology1.96065435
24MP0000566_synostosis1.93411349
25MP0003984_embryonic_growth_retardation1.93140636
26MP0002088_abnormal_embryonic_growth/wei1.90949870
27MP0010234_abnormal_vibrissa_follicle1.87981262
28MP0008058_abnormal_DNA_repair1.85090501
29MP0002085_abnormal_embryonic_tissue1.82350980
30MP0002080_prenatal_lethality1.80749660
31MP0000579_abnormal_nail_morphology1.77499862
32MP0002086_abnormal_extraembryonic_tissu1.76497107
33MP0003566_abnormal_cell_adhesion1.72796663
34MP0003567_abnormal_fetal_cardiomyocyte1.64115123
35MP0008877_abnormal_DNA_methylation1.61184152
36MP0000678_abnormal_parathyroid_gland1.53038610
37MP0005409_darkened_coat_color1.47580626
38MP0002060_abnormal_skin_morphology1.47479216
39MP0005257_abnormal_intraocular_pressure1.47172675
40MP0009053_abnormal_anal_canal1.46397237
41MP0008438_abnormal_cutaneous_collagen1.40762817
42MP0002396_abnormal_hematopoietic_system1.40623846
43MP0004808_abnormal_hematopoietic_stem1.37197843
44MP0005623_abnormal_meninges_morphology1.36985398
45MP0002089_abnormal_postnatal_growth/wei1.35905780
46MP0001661_extended_life_span1.35474607
47MP0001849_ear_inflammation1.34764115
48MP0000733_abnormal_muscle_development1.33077960
49MP0003119_abnormal_digestive_system1.33016352
50MP0003121_genomic_imprinting1.32900163
51MP0005023_abnormal_wound_healing1.32441511
52MP0000751_myopathy1.29786576
53MP0003786_premature_aging1.29093173
54MP0009672_abnormal_birth_weight1.28385672
55MP0004858_abnormal_nervous_system1.28113034
56MP0003453_abnormal_keratinocyte_physiol1.27507998
57MP0000467_abnormal_esophagus_morphology1.25869971
58MP0010030_abnormal_orbit_morphology1.25034625
59MP0002249_abnormal_larynx_morphology1.21816631
60MP0002877_abnormal_melanocyte_morpholog1.20780554
61MP0003890_abnormal_embryonic-extraembry1.20664497
62MP0000428_abnormal_craniofacial_morphol1.19997539
63MP0000490_abnormal_crypts_of1.19690218
64MP0000313_abnormal_cell_death1.18943452
65MP0002098_abnormal_vibrissa_morphology1.16953338
66MP0000762_abnormal_tongue_morphology1.16623710
67MP0000003_abnormal_adipose_tissue1.14697111
68MP0009703_decreased_birth_body1.14188004
69MP0005058_abnormal_lysosome_morphology1.13296513
70MP0001293_anophthalmia1.11885123
71MP0003942_abnormal_urinary_system1.11047770
72MP0008260_abnormal_autophagy1.10981758
73MP0006054_spinal_hemorrhage1.10630674
74MP0002019_abnormal_tumor_incidence1.07960801
75MP0003937_abnormal_limbs/digits/tail_de1.07135066
76MP0010630_abnormal_cardiac_muscle1.05982951
77MP0001346_abnormal_lacrimal_gland1.04603329
78MP0004185_abnormal_adipocyte_glucose1.03743967
79MP0001915_intracranial_hemorrhage1.01570324
80MP0004233_abnormal_muscle_weight1.01496036
81MP0003385_abnormal_body_wall0.99010586
82MP0002111_abnormal_tail_morphology0.98514568
83MP0002697_abnormal_eye_size0.96768759
84MP0001216_abnormal_epidermal_layer0.95057257
85MP0002092_abnormal_eye_morphology0.94853259
86MP0005621_abnormal_cell_physiology0.94252284
87MP0003283_abnormal_digestive_organ0.93503599
88MP0000747_muscle_weakness0.93160775
89MP0002269_muscular_atrophy0.92617908
90MP0000462_abnormal_digestive_system0.92006189
91MP0000534_abnormal_ureter_morphology0.91903619
92MP0003115_abnormal_respiratory_system0.91772106
93MP0004087_abnormal_muscle_fiber0.91036324
94MP0005384_cellular_phenotype0.90369921
95MP0003718_maternal_effect0.89141351
96MP0009780_abnormal_chondrocyte_physiolo0.89093240
97MP0000358_abnormal_cell_content/0.89066590
98MP0004782_abnormal_surfactant_physiolog0.88213444
99MP0003300_gastrointestinal_ulcer0.87819077
100MP0000759_abnormal_skeletal_muscle0.85763313
101MP0003303_peritoneal_inflammation0.84115601
102MP0005666_abnormal_adipose_tissue0.83785469
103MP0002210_abnormal_sex_determination0.83698502
104MP0009333_abnormal_splenocyte_physiolog0.82703332
105MP0005275_abnormal_skin_tensile0.82684664
106MP0004264_abnormal_extraembryonic_tissu0.82523948
107MP0003221_abnormal_cardiomyocyte_apopto0.82312688
108MP0001145_abnormal_male_reproductive0.81852738
109MP0005375_adipose_tissue_phenotype0.81816324
110MP0009278_abnormal_bone_marrow0.81814775
111MP0000703_abnormal_thymus_morphology0.81603209
112MP0000432_abnormal_head_morphology0.81081336
113MP0002925_abnormal_cardiovascular_devel0.81018284
114MP0000750_abnormal_muscle_regeneration0.80367250
115MP0004272_abnormal_basement_membrane0.80121531
116MP0002653_abnormal_ependyma_morphology0.80081032
117MP0001881_abnormal_mammary_gland0.79133511
118MP0003315_abnormal_perineum_morphology0.78544960
119MP0008770_decreased_survivor_rate0.77389742
120MP0009931_abnormal_skin_appearance0.76992072
121MP0003935_abnormal_craniofacial_develop0.76389443
122MP0003941_abnormal_skin_development0.76382199
123MP0003091_abnormal_cell_migration0.76170072
124MP0010771_integument_phenotype0.75982507
125MP0005408_hypopigmentation0.74844890
126MP0001348_abnormal_lacrimal_gland0.73508287
127MP0000477_abnormal_intestine_morphology0.69978430
128MP0000627_abnormal_mammary_gland0.69369736
129MP0001286_abnormal_eye_development0.68586237
130MP0005501_abnormal_skin_physiology0.66913368
131MP0004133_heterotaxia0.66269323
132MP0000858_altered_metastatic_potential0.66186750
133MP0000377_abnormal_hair_follicle0.66075939
134MP0003861_abnormal_nervous_system0.65590257
135MP0003755_abnormal_palate_morphology0.64753239
136MP0001727_abnormal_embryo_implantation0.64486874
137MP0001929_abnormal_gametogenesis0.63307273
138MP0000653_abnormal_sex_gland0.61021148
139MP0010678_abnormal_skin_adnexa0.60469177

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.42719758
2Ependymoma (HP:0002888)3.72255457
3Proximal placement of thumb (HP:0009623)3.34030230
4Deviation of the thumb (HP:0009603)3.33610776
5Insomnia (HP:0100785)3.33216238
6Colon cancer (HP:0003003)3.32991990
7Selective tooth agenesis (HP:0001592)3.32571463
8Breast hypoplasia (HP:0003187)3.01447459
9Abnormality of the anterior horn cell (HP:0006802)2.91707800
10Degeneration of anterior horn cells (HP:0002398)2.91707800
11Birth length less than 3rd percentile (HP:0003561)2.91017760
12Protrusio acetabuli (HP:0003179)2.88107145
13Abnormality of the labia minora (HP:0012880)2.87190670
14Premature rupture of membranes (HP:0001788)2.81655993
15Biliary tract neoplasm (HP:0100574)2.76002738
16Abnormality of the astrocytes (HP:0100707)2.75420417
17Astrocytoma (HP:0009592)2.75420417
18Distal upper limb amyotrophy (HP:0007149)2.72074839
19Upper limb amyotrophy (HP:0009129)2.72074839
20Trismus (HP:0000211)2.67633228
21Asymmetry of the thorax (HP:0001555)2.67193866
22Medulloblastoma (HP:0002885)2.59849578
23Cholecystitis (HP:0001082)2.58991986
24Abnormal gallbladder physiology (HP:0012438)2.58991986
25Overriding aorta (HP:0002623)2.58869614
26Reticulocytopenia (HP:0001896)2.58205459
27Renal duplication (HP:0000075)2.57485790
28Abnormality of the calcaneus (HP:0008364)2.53543913
29Pelvic girdle muscle weakness (HP:0003749)2.52255521
30Distal lower limb amyotrophy (HP:0008944)2.48638828
31Ankle contracture (HP:0006466)2.48308855
32Increased nuchal translucency (HP:0010880)2.44351962
33Elfin facies (HP:0004428)2.44260330
34Impulsivity (HP:0100710)2.44094131
35Shallow orbits (HP:0000586)2.43271025
36Flat acetabular roof (HP:0003180)2.40996965
37Progressive muscle weakness (HP:0003323)2.40894992
38Neoplasm of the pancreas (HP:0002894)2.37941149
39Increased connective tissue (HP:0009025)2.37552039
40Patellar aplasia (HP:0006443)2.36124259
41Microvesicular hepatic steatosis (HP:0001414)2.34582332
42Basal cell carcinoma (HP:0002671)2.34157646
43Carpal bone hypoplasia (HP:0001498)2.33346312
44Rhabdomyosarcoma (HP:0002859)2.31652514
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31211012
46Achilles tendon contracture (HP:0001771)2.30890276
47Missing ribs (HP:0000921)2.29878474
48Glioma (HP:0009733)2.27161659
49Shoulder girdle muscle weakness (HP:0003547)2.27115862
50Aplasia/Hypoplasia of the patella (HP:0006498)2.26100442
51Aplasia/hypoplasia of the humerus (HP:0006507)2.25640553
52Renovascular hypertension (HP:0100817)2.24648162
53Chromsome breakage (HP:0040012)2.24435338
54Long palpebral fissure (HP:0000637)2.24184855
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.20777769
56Back pain (HP:0003418)2.20654279
57Absent radius (HP:0003974)2.20360799
58Advanced eruption of teeth (HP:0006288)2.19717527
59Increased density of long bones (HP:0006392)2.19472251
60Deep venous thrombosis (HP:0002625)2.18761198
61Atresia of the external auditory canal (HP:0000413)2.18018796
62Prominent nose (HP:0000448)2.16378990
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16141957
64Genu recurvatum (HP:0002816)2.15388925
65Abnormality of glycolysis (HP:0004366)2.15167542
66Broad face (HP:0000283)2.14068926
67Rectal prolapse (HP:0002035)2.12641303
68Volvulus (HP:0002580)2.11423559
69Disproportionate tall stature (HP:0001519)2.10395915
70Premature skin wrinkling (HP:0100678)2.10098473
71Rough bone trabeculation (HP:0100670)2.09251578
72Vertebral compression fractures (HP:0002953)2.09230344
73Abnormality of the Achilles tendon (HP:0005109)2.09185503
74Short humerus (HP:0005792)2.08453727
75Cervical subluxation (HP:0003308)2.07647318
76Pointed chin (HP:0000307)2.07068133
77Malignant gastrointestinal tract tumors (HP:0006749)2.06753112
78Gastrointestinal carcinoma (HP:0002672)2.06753112
79Ragged-red muscle fibers (HP:0003200)2.05554422
80Agnosia (HP:0010524)2.04131260
81Abnormality of the musculature of the pelvis (HP:0001469)2.03469011
82Abnormality of the hip-girdle musculature (HP:0001445)2.03469011
83Abnormality of cells of the erythroid lineage (HP:0012130)2.03111273
84Absent forearm bone (HP:0003953)2.02612479
85Aplasia involving forearm bones (HP:0009822)2.02612479
86Reticulocytosis (HP:0001923)2.02444836
87Cerebral hypomyelination (HP:0006808)2.00818528
88Short 4th metacarpal (HP:0010044)2.00813331
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00813331
90Natal tooth (HP:0000695)1.99819703
91Sparse lateral eyebrow (HP:0005338)1.98795475
92Ankyloglossia (HP:0010296)1.98429200
93Abnormal number of incisors (HP:0011064)1.98162883
94Multiple enchondromatosis (HP:0005701)1.98139305
95High pitched voice (HP:0001620)1.97954401
96Angiofibromas (HP:0010615)1.96404880
97Adenoma sebaceum (HP:0009720)1.96404880
98Neoplasm of the oral cavity (HP:0100649)1.96146160
99Pterygium (HP:0001059)1.94874822
100Glossoptosis (HP:0000162)1.94548286
101Overlapping toe (HP:0001845)1.93955714
102Patellar dislocation (HP:0002999)1.93426860
103Oral leukoplakia (HP:0002745)1.91974918
104Neoplasm of striated muscle (HP:0009728)1.91700995
105Urethral obstruction (HP:0000796)1.91434302
106Fragile skin (HP:0001030)1.89812815
107Right ventricular cardiomyopathy (HP:0011663)1.88168416
108Septate vagina (HP:0001153)1.87781161
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.87505158
110Macrocytic anemia (HP:0001972)1.86174415
111Abnormality of the salivary glands (HP:0010286)1.85697249
112Dysmetric saccades (HP:0000641)1.85129876
113Facial hemangioma (HP:0000329)1.83536979
114Distal lower limb muscle weakness (HP:0009053)1.83253995
115Broad distal phalanx of finger (HP:0009836)1.83154364
116Cerebral aneurysm (HP:0004944)1.83111384
117Absent epiphyses (HP:0010577)1.82968376
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82968376
119Squamous cell carcinoma (HP:0002860)1.82496396
120Abnormality of reticulocytes (HP:0004312)1.82235003
121Lower limb amyotrophy (HP:0007210)1.82230766
122High anterior hairline (HP:0009890)1.81922398
123Abnormality of the thoracic spine (HP:0100711)1.80626814
124Bladder diverticulum (HP:0000015)1.79000466
125Hand muscle atrophy (HP:0009130)1.78969741
126Osteolytic defects of the hand bones (HP:0009699)1.78738073
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.78738073
128Abnormality of oral frenula (HP:0000190)1.77983719
129Difficulty climbing stairs (HP:0003551)1.77837257
130Metaphyseal cupping (HP:0003021)1.77676934
131Myopathic facies (HP:0002058)1.77316974
132Wrist flexion contracture (HP:0001239)1.77263661
133Spinal rigidity (HP:0003306)1.77168613
134Arnold-Chiari malformation (HP:0002308)1.76190267
135Abnormality of the umbilical cord (HP:0010881)1.75648953
136Microglossia (HP:0000171)1.75533649
137Termporal pattern (HP:0011008)1.75063499
138Insidious onset (HP:0003587)1.75063499
139Impaired pain sensation (HP:0007328)1.74949121
140Abnormality of pain sensation (HP:0010832)1.74949121
141Neoplasm of the rectum (HP:0100743)1.74817746
142Ulnar bowing (HP:0003031)1.74590475
143Amaurosis fugax (HP:0100576)1.73150318
144Sandal gap (HP:0001852)1.73049431
145Persistence of primary teeth (HP:0006335)1.73023993
146Short nail (HP:0001799)1.72675331
147Spinal muscular atrophy (HP:0007269)1.72664047
148Bowel diverticulosis (HP:0005222)1.71180053
149Cutaneous melanoma (HP:0012056)1.70857303
150J-shaped sella turcica (HP:0002680)1.70154136
151Abnormal biliary tract morphology (HP:0012440)1.69983675
152Ovarian neoplasm (HP:0100615)1.69887475
153Skin tags (HP:0010609)1.69858197
154Breech presentation (HP:0001623)1.69760766
155Neoplasm of the colon (HP:0100273)1.69546038
156Flat cornea (HP:0007720)1.69303915
157Cafe-au-lait spot (HP:0000957)1.69232540
158Absent thumb (HP:0009777)1.69017661
15911 pairs of ribs (HP:0000878)1.68141574
160Progressive external ophthalmoplegia (HP:0000590)1.67776439
161Pili torti (HP:0003777)1.67684165
162Pseudobulbar signs (HP:0002200)1.67484259
163Slender long bone (HP:0003100)1.67271750
164Abnormal number of erythroid precursors (HP:0012131)1.66545212
165Preauricular skin tag (HP:0000384)1.66373209
166Mildly elevated creatine phosphokinase (HP:0008180)1.66250740
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.66201633
168Progressive hearing impairment (HP:0001730)1.65759920
169Uterine neoplasm (HP:0010784)1.65713755
170Esophageal atresia (HP:0002032)1.65634561
171Fused cervical vertebrae (HP:0002949)1.65519849
172Heterotopia (HP:0002282)1.65000067
173Increased serum pyruvate (HP:0003542)1.63204318
174Cortical dysplasia (HP:0002539)1.62530923
175Biconcave vertebral bodies (HP:0004586)1.60924615
176Precocious puberty (HP:0000826)1.59974557
177Abnormality of the acetabulum (HP:0003170)1.59608097
178Deep philtrum (HP:0002002)1.58718905
179Hammertoe (HP:0001765)1.56602238
180Vertebral arch anomaly (HP:0008438)1.56142360
181Abnormality of the distal phalanges of the toes (HP:0010182)1.54973497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.75985535
2SMG13.75551427
3BUB13.57890822
4WEE13.32358586
5CDK122.99318157
6NEK22.90772647
7EEF2K2.88628126
8TSSK62.76835740
9EPHA22.34682724
10MST1R2.27569610
11SIK12.21750040
12NEK12.21532125
13PKN22.18688690
14TTK2.18106559
15PASK2.06137186
16TRIB32.04369364
17PNCK2.00133572
18EIF2AK11.99215283
19IRAK31.98414309
20FGFR41.90153798
21RPS6KB21.84015817
22SCYL21.80220136
23ALK1.74082455
24MAP3K101.64379804
25PLK11.60973447
26BRSK21.59536416
27PLK31.53636500
28PAK41.52633752
29MAP3K81.51822275
30STK101.49433265
31AURKB1.45631022
32TESK21.41350129
33BRD41.41219855
34SRPK11.40558596
35MKNK11.38682793
36PRPF4B1.37270493
37CDK41.35859223
38CHEK11.35026124
39TTN1.34745907
40NTRK11.34058604
41CDK71.28526078
42RPS6KA41.26679695
43LMTK21.23749101
44ATR1.23350742
45NME21.22335437
46MTOR1.19659258
47LATS11.16549067
48LRRK21.15732765
49PBK1.14643797
50TGFBR11.05312764
51CDK61.04364860
52VRK21.01872540
53LATS21.01453415
54PLK41.01243180
55ERN11.00495161
56CHEK20.98421440
57CDK80.96997914
58PAK20.96087793
59AURKA0.95709994
60ACVR1B0.94663494
61DYRK30.93826736
62STK30.93432423
63TESK10.91204714
64* CDK20.89916426
65ATM0.86795646
66PDGFRA0.82952226
67MKNK20.82932570
68TLK10.82225644
69EIF2AK30.81999768
70MET0.81545948
71PTK60.81079789
72PDK40.80027885
73PDK30.80027885
74PAK10.79934070
75CSNK1E0.78437457
76FGFR10.77500792
77ICK0.77168159
78MELK0.74278748
79BRSK10.71448938
80KSR20.71416574
81BMX0.67882481
82CLK10.67381593
83MAP2K30.66673338
84CDK10.65214767
85MAPK110.65047552
86* CSNK2A20.64998382
87PRKCI0.64978125
88BRAF0.64969592
89ARAF0.63473576
90MAP3K90.61136035
91MAPKAPK30.59382764
92PIM10.57887518
93RPS6KA20.57434772
94ILK0.56997497
95STK40.54165075
96CDK11A0.53499935
97CDK90.52663384
98TAOK20.51780860
99CDK150.51772306
100CSNK1D0.51380856
101CDK180.48559364
102DMPK0.48372352
103PTK20.47636041
104PIM20.45256284
105* PRKDC0.43384956
106TYRO30.43210091
107PRKD30.42788880
108EPHB10.42785704
109RET0.41205405
110AKT20.41137264
111DAPK10.40714859
112CDK140.40204926
113FLT30.40202597
114RPS6KB10.40198401
115IRAK20.39744463
116ERBB40.39671591
117DDR20.39517403
118CSNK2A10.38582201
119RPS6KA50.38581205
120ZAP700.38361466
121PDPK10.37221936
122FER0.35567587
123MARK20.35125884
124CAMK1D0.34611058
125MAP2K20.34336735
126MAP4K10.34168043
127PDGFRB0.33857516
128LIMK10.33302659
129PDK20.32769120
130MAPK140.32450346
131EPHA30.31744507
132MAP3K30.29901522
133NME10.29286572
134RIPK10.28096784
135RPS6KA10.26078128
136MAPK10.25906717
137GSK3B0.24554968
138MARK30.23840177
139CSNK1A1L0.22165319

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84642234
2* RNA transport_Homo sapiens_hsa030133.66795967
3DNA replication_Homo sapiens_hsa030303.65775353
4Spliceosome_Homo sapiens_hsa030403.31815314
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.21650526
6Mismatch repair_Homo sapiens_hsa034303.13842865
7One carbon pool by folate_Homo sapiens_hsa006703.13173046
8Cell cycle_Homo sapiens_hsa041102.80643089
9Ribosome_Homo sapiens_hsa030102.59645849
10RNA polymerase_Homo sapiens_hsa030202.56591994
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38891029
12Proteasome_Homo sapiens_hsa030502.38127654
13Nucleotide excision repair_Homo sapiens_hsa034202.25731981
14mRNA surveillance pathway_Homo sapiens_hsa030152.23298357
15Base excision repair_Homo sapiens_hsa034102.15244591
16Homologous recombination_Homo sapiens_hsa034401.82242364
17p53 signaling pathway_Homo sapiens_hsa041151.73569136
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61332775
19Fructose and mannose metabolism_Homo sapiens_hsa000511.59787510
20Pyrimidine metabolism_Homo sapiens_hsa002401.59006385
21RNA degradation_Homo sapiens_hsa030181.53564410
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53193022
23Basal transcription factors_Homo sapiens_hsa030221.47008315
24Non-homologous end-joining_Homo sapiens_hsa034501.44008056
25Epstein-Barr virus infection_Homo sapiens_hsa051691.42370351
26Viral carcinogenesis_Homo sapiens_hsa052031.41430554
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40220585
28Fanconi anemia pathway_Homo sapiens_hsa034601.39332197
29Antigen processing and presentation_Homo sapiens_hsa046121.34100164
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32445785
31MicroRNAs in cancer_Homo sapiens_hsa052061.24459284
32Oocyte meiosis_Homo sapiens_hsa041141.24053396
33Galactose metabolism_Homo sapiens_hsa000521.22339786
34Small cell lung cancer_Homo sapiens_hsa052221.18272307
35Sulfur relay system_Homo sapiens_hsa041221.15430527
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11766239
37Vitamin B6 metabolism_Homo sapiens_hsa007501.09389167
38HTLV-I infection_Homo sapiens_hsa051661.08269935
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07345455
40Biosynthesis of amino acids_Homo sapiens_hsa012301.07161878
41Adherens junction_Homo sapiens_hsa045201.02685030
42Hippo signaling pathway_Homo sapiens_hsa043901.01762672
43Selenocompound metabolism_Homo sapiens_hsa004500.99403165
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.98961762
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98490335
46Chronic myeloid leukemia_Homo sapiens_hsa052200.98452963
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97881890
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97451938
49Systemic lupus erythematosus_Homo sapiens_hsa053220.97047022
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96073258
51Arginine biosynthesis_Homo sapiens_hsa002200.95845456
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95724832
53mTOR signaling pathway_Homo sapiens_hsa041500.95556634
54Pyruvate metabolism_Homo sapiens_hsa006200.93142906
55Insulin signaling pathway_Homo sapiens_hsa049100.93113347
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.87562416
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85953449
58Other glycan degradation_Homo sapiens_hsa005110.82185563
59Tight junction_Homo sapiens_hsa045300.81860570
60Thyroid cancer_Homo sapiens_hsa052160.81756547
61Bladder cancer_Homo sapiens_hsa052190.81333598
62Prion diseases_Homo sapiens_hsa050200.81120954
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.79478845
64Steroid biosynthesis_Homo sapiens_hsa001000.78185064
65TGF-beta signaling pathway_Homo sapiens_hsa043500.77028751
66Proteoglycans in cancer_Homo sapiens_hsa052050.76867621
67ErbB signaling pathway_Homo sapiens_hsa040120.75249113
68Pentose phosphate pathway_Homo sapiens_hsa000300.74930439
69Colorectal cancer_Homo sapiens_hsa052100.74529977
70Herpes simplex infection_Homo sapiens_hsa051680.71920711
71HIF-1 signaling pathway_Homo sapiens_hsa040660.69922375
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69882207
73Viral myocarditis_Homo sapiens_hsa054160.69443233
74Prostate cancer_Homo sapiens_hsa052150.69096657
75Basal cell carcinoma_Homo sapiens_hsa052170.68090026
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67964484
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67891742
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67222215
79Purine metabolism_Homo sapiens_hsa002300.67104582
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65203565
81Glucagon signaling pathway_Homo sapiens_hsa049220.62477806
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62305106
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62168261
84Phenylalanine metabolism_Homo sapiens_hsa003600.61317268
85Arginine and proline metabolism_Homo sapiens_hsa003300.61280092
86Apoptosis_Homo sapiens_hsa042100.60675701
87Focal adhesion_Homo sapiens_hsa045100.59957931
88Hedgehog signaling pathway_Homo sapiens_hsa043400.59897001
89Legionellosis_Homo sapiens_hsa051340.59155615
90Renal cell carcinoma_Homo sapiens_hsa052110.58556404
91Shigellosis_Homo sapiens_hsa051310.57102357
92Fatty acid elongation_Homo sapiens_hsa000620.54805069
93ECM-receptor interaction_Homo sapiens_hsa045120.54272984
94Vibrio cholerae infection_Homo sapiens_hsa051100.53684081
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53468271
96Carbon metabolism_Homo sapiens_hsa012000.52052064
97Pathways in cancer_Homo sapiens_hsa052000.51717748
98Inositol phosphate metabolism_Homo sapiens_hsa005620.51150235
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.51136401
100Endometrial cancer_Homo sapiens_hsa052130.50005325
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49564290
102Acute myeloid leukemia_Homo sapiens_hsa052210.48688991
103Notch signaling pathway_Homo sapiens_hsa043300.47894508
104Hepatitis B_Homo sapiens_hsa051610.47359244
105Fatty acid metabolism_Homo sapiens_hsa012120.46700114
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46581194
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45548284
108Pancreatic cancer_Homo sapiens_hsa052120.44876750
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43505406
110Non-small cell lung cancer_Homo sapiens_hsa052230.42061780
111Estrogen signaling pathway_Homo sapiens_hsa049150.40006496
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39870699
113Melanoma_Homo sapiens_hsa052180.39548048
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38782495
115VEGF signaling pathway_Homo sapiens_hsa043700.36562277
116Wnt signaling pathway_Homo sapiens_hsa043100.35717647
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34779689
118N-Glycan biosynthesis_Homo sapiens_hsa005100.34238720
119AMPK signaling pathway_Homo sapiens_hsa041520.34063645
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33385503
121FoxO signaling pathway_Homo sapiens_hsa040680.32130745
122T cell receptor signaling pathway_Homo sapiens_hsa046600.31240850
123Lysine degradation_Homo sapiens_hsa003100.31036205
124Alcoholism_Homo sapiens_hsa050340.28699666
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28158486
126Toxoplasmosis_Homo sapiens_hsa051450.26722663
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.26158042
128Glioma_Homo sapiens_hsa052140.26041696
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25332491
130Measles_Homo sapiens_hsa051620.24971047
131Amoebiasis_Homo sapiens_hsa051460.24755787
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.23297499
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22030737

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