EIF3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.22282408
2transcription from mitochondrial promoter (GO:0006390)7.32188166
3embryonic process involved in female pregnancy (GO:0060136)6.90378449
4replication fork processing (GO:0031297)6.84363651
5proline metabolic process (GO:0006560)6.79376636
6DNA deamination (GO:0045006)5.99098210
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.78920023
8positive regulation of protein homooligomerization (GO:0032464)5.54932925
9establishment of apical/basal cell polarity (GO:0035089)5.44215322
10ribosomal small subunit assembly (GO:0000028)5.42611820
11somatic diversification of immune receptors via somatic mutation (GO:0002566)5.27258265
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.27258265
13regulation of integrin activation (GO:0033623)5.23892584
14oxidative demethylation (GO:0070989)5.19755454
15mitochondrial DNA metabolic process (GO:0032042)5.18368013
16DNA strand renaturation (GO:0000733)5.18245539
17ribosomal small subunit biogenesis (GO:0042274)4.84487668
18regulation of protein homooligomerization (GO:0032462)4.84390010
19viral transcription (GO:0019083)4.82794425
20mitotic G1 DNA damage checkpoint (GO:0031571)4.79547081
21viral mRNA export from host cell nucleus (GO:0046784)4.72900154
22regulation of translational fidelity (GO:0006450)4.72541776
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.67311221
24establishment of monopolar cell polarity (GO:0061162)4.67311221
25translational termination (GO:0006415)4.61285469
26ribosomal large subunit biogenesis (GO:0042273)4.57760843
27DNA unwinding involved in DNA replication (GO:0006268)4.53296343
28maturation of SSU-rRNA (GO:0030490)4.52662904
29mRNA cleavage (GO:0006379)4.47074640
30telomere maintenance via semi-conservative replication (GO:0032201)4.44238051
31poly(A)+ mRNA export from nucleus (GO:0016973)4.32934146
32nuclear pore complex assembly (GO:0051292)4.23280721
33base-excision repair (GO:0006284)4.22388689
34mitotic G1/S transition checkpoint (GO:0044819)4.21650068
35G1 DNA damage checkpoint (GO:0044783)4.20803393
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19648204
37translational elongation (GO:0006414)4.18770734
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.15450836
39spliceosomal tri-snRNP complex assembly (GO:0000244)4.15097701
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.13874626
41establishment of protein localization to mitochondrial membrane (GO:0090151)4.07853259
42cotranslational protein targeting to membrane (GO:0006613)4.07462022
43protein targeting to ER (GO:0045047)4.07064659
44* translational initiation (GO:0006413)3.99362261
45regulation of RNA export from nucleus (GO:0046831)3.97043949
46negative regulation of JAK-STAT cascade (GO:0046426)3.96883722
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.96668328
48embryonic placenta development (GO:0001892)3.93590957
49DNA strand elongation involved in DNA replication (GO:0006271)3.92063850
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.89965231
51ribonucleoprotein complex biogenesis (GO:0022613)3.89253934
52negative regulation of cell cycle arrest (GO:0071157)3.88797200
53establishment of integrated proviral latency (GO:0075713)3.86493628
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.83172495
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.83172495
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.83172495
57protein localization to endoplasmic reticulum (GO:0070972)3.81965248
58ribosome assembly (GO:0042255)3.79824476
59dosage compensation (GO:0007549)3.78547691
60viral life cycle (GO:0019058)3.78036325
61mitochondrial RNA metabolic process (GO:0000959)3.73571796
62nuclear pore organization (GO:0006999)3.73332565
63DNA double-strand break processing (GO:0000729)3.71217334
64non-recombinational repair (GO:0000726)3.70581269
65double-strand break repair via nonhomologous end joining (GO:0006303)3.70581269
66regulation of sister chromatid cohesion (GO:0007063)3.69768102
67DNA strand elongation (GO:0022616)3.69659541
68negative regulation of mRNA processing (GO:0050686)3.64979296
69DNA integration (GO:0015074)3.63268308
70telomere maintenance via recombination (GO:0000722)3.63253628
71cellular protein complex disassembly (GO:0043624)3.57585771
72termination of RNA polymerase II transcription (GO:0006369)3.57522003
73meiotic chromosome segregation (GO:0045132)3.55337149
74cellular response to ATP (GO:0071318)3.55270136
75mitotic chromosome condensation (GO:0007076)3.54037652
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.51606685
77positive regulation of protein oligomerization (GO:0032461)3.50475708
78glutamine family amino acid biosynthetic process (GO:0009084)3.49464128
79maturation of 5.8S rRNA (GO:0000460)3.49012822
80negative regulation of fatty acid biosynthetic process (GO:0045717)3.48901310
81DNA topological change (GO:0006265)3.48500554
82regulation of gene silencing by RNA (GO:0060966)3.44824252
83regulation of posttranscriptional gene silencing (GO:0060147)3.44824252
84regulation of gene silencing by miRNA (GO:0060964)3.44824252
85cellular response to zinc ion (GO:0071294)3.42464624
86COPI coating of Golgi vesicle (GO:0048205)3.41906223
87Golgi transport vesicle coating (GO:0048200)3.41906223
88trophectodermal cell differentiation (GO:0001829)3.41688795
89base-excision repair, AP site formation (GO:0006285)3.41510384
90negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38726818
91positive regulation of chromosome segregation (GO:0051984)3.38259780
92positive regulation by host of viral transcription (GO:0043923)3.36461120
93histone H4-K12 acetylation (GO:0043983)3.36360214
94positive regulation of developmental pigmentation (GO:0048087)3.34917893
95negative regulation of RNA splicing (GO:0033119)3.33860838
96DNA replication initiation (GO:0006270)3.30083396
97nodal signaling pathway (GO:0038092)3.29820556
98folic acid-containing compound biosynthetic process (GO:0009396)3.29663580
99protein complex disassembly (GO:0043241)3.29395032
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.28850119
101regulation of double-strand break repair (GO:2000779)3.26995225
102regulation of DNA damage checkpoint (GO:2000001)3.26759791
103embryonic camera-type eye development (GO:0031076)3.23518030
104pore complex assembly (GO:0046931)3.22233310
105kinetochore assembly (GO:0051382)3.19483594
106apoptotic process involved in morphogenesis (GO:0060561)3.19381457
107regulation of protein oligomerization (GO:0032459)3.17335044
108* translation (GO:0006412)3.17258067
109negative regulation of protein oligomerization (GO:0032460)3.16159867
110establishment of viral latency (GO:0019043)3.15785740
111mitotic recombination (GO:0006312)3.15314319
112DNA ligation (GO:0006266)3.14761400
113telomere maintenance via telomere lengthening (GO:0010833)3.13851156
114mitotic sister chromatid segregation (GO:0000070)3.12682634
115macromolecular complex disassembly (GO:0032984)3.11766711
116tRNA aminoacylation for protein translation (GO:0006418)3.09706577
117* formation of translation preinitiation complex (GO:0001731)3.07352359
118negative regulation of Ras GTPase activity (GO:0034261)3.05634411
119mitochondrial DNA replication (GO:0006264)3.04868031
120nuclear-transcribed mRNA catabolic process (GO:0000956)3.02412135
121mitotic nuclear envelope reassembly (GO:0007084)3.01487976
122nuclear envelope reassembly (GO:0031468)3.01487976
123IMP biosynthetic process (GO:0006188)3.00635829
124rRNA processing (GO:0006364)2.99906402
125negative regulation of mRNA metabolic process (GO:1903312)2.98715010
126GDP-mannose metabolic process (GO:0019673)2.98594387
127regulation of nucleobase-containing compound transport (GO:0032239)2.98429694
128amino acid activation (GO:0043038)2.98426817
129tRNA aminoacylation (GO:0043039)2.98426817
130convergent extension (GO:0060026)2.97917386
131positive regulation of DNA repair (GO:0045739)2.95645463
132face development (GO:0060324)2.95044153
133nucleobase-containing small molecule interconversion (GO:0015949)2.93459954
134mRNA export from nucleus (GO:0006406)2.91477377
135ribosome biogenesis (GO:0042254)2.90605506
136mitotic nuclear envelope disassembly (GO:0007077)2.90168009
137determination of adult lifespan (GO:0008340)2.89882037
138mRNA catabolic process (GO:0006402)2.89769026
139protein targeting to membrane (GO:0006612)2.87640953
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85149705
141labyrinthine layer development (GO:0060711)2.84542011
142nuclear envelope disassembly (GO:0051081)2.84479607
143membrane disassembly (GO:0030397)2.84479607
144rRNA metabolic process (GO:0016072)2.83705386
145DNA demethylation (GO:0080111)2.83658479
146nucleobase biosynthetic process (GO:0046112)2.82345218
147regulation of translational termination (GO:0006449)2.76495848
148RNA catabolic process (GO:0006401)2.76165227
149purine nucleobase biosynthetic process (GO:0009113)2.73139424
150DNA duplex unwinding (GO:0032508)2.73084316
151sister chromatid segregation (GO:0000819)2.69258493
152cellular component biogenesis (GO:0044085)2.68566960
153negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68435469
154negative regulation of ligase activity (GO:0051352)2.68435469
155regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.67026319
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66836304
157protein localization to chromosome, centromeric region (GO:0071459)2.66027372
158mitotic metaphase plate congression (GO:0007080)2.65171117
159IMP metabolic process (GO:0046040)2.64011304
160anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63630644
161peptidyl-arginine omega-N-methylation (GO:0035247)2.63447171
162positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62423315
163DNA geometric change (GO:0032392)2.58893356
164pentose-phosphate shunt (GO:0006098)2.56059372
165mRNA splicing, via spliceosome (GO:0000398)2.43687385
166RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.43687385
167signal transduction involved in DNA integrity checkpoint (GO:0072401)2.42718100
168signal transduction involved in DNA damage checkpoint (GO:0072422)2.42718100
169transcription-coupled nucleotide-excision repair (GO:0006283)2.41510670
170* ribonucleoprotein complex assembly (GO:0022618)2.41420897
171protein maturation by protein folding (GO:0022417)2.40815827
172mitotic sister chromatid cohesion (GO:0007064)2.40601772
173pinocytosis (GO:0006907)2.40383522
174cellular hyperosmotic response (GO:0071474)2.40381544
175spliceosomal snRNP assembly (GO:0000387)2.39857691
176DNA replication checkpoint (GO:0000076)2.39737584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.58194055
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.50981336
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03846415
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.99248530
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80804700
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75706581
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69665050
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.66133908
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.60283121
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.59097633
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.59097633
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.59097633
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57228003
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44049963
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25805445
16VDR_21846776_ChIP-Seq_THP-1_Human2.24754876
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21483428
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.14410072
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02718188
20KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.02261423
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01949241
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99759693
23MYC_22102868_ChIP-Seq_BL_Human1.93598452
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.92794768
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92263603
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89684475
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88149644
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88077991
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85558649
30* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85199710
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83872866
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83387767
33FOXP3_21729870_ChIP-Seq_TREG_Human1.77598294
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75854606
35POU5F1_16518401_ChIP-PET_MESCs_Mouse1.71055255
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69364355
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69043816
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69014613
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65913084
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.65333654
41* ETS1_20019798_ChIP-Seq_JURKAT_Human1.64438667
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62972550
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62237351
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61003635
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58951590
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56957073
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56144507
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55711887
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55314128
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53444216
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52380638
52XRN2_22483619_ChIP-Seq_HELA_Human1.52262051
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51700972
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51665289
55CIITA_25753668_ChIP-Seq_RAJI_Human1.49228658
56* GABP_19822575_ChIP-Seq_HepG2_Human1.47838675
57AR_21909140_ChIP-Seq_LNCAP_Human1.47829586
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47231925
59LXR_22292898_ChIP-Seq_THP-1_Human1.44192170
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.43952183
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43504237
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43185509
63* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.42160306
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41521530
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40804639
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39808635
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38345551
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37830871
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36782259
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36356023
71KDM5A_27292631_Chip-Seq_BREAST_Human1.36334879
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34967833
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34893662
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.32173327
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31410167
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.30996073
77* DCP1A_22483619_ChIP-Seq_HELA_Human1.30817982
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30506341
79ZNF263_19887448_ChIP-Seq_K562_Human1.30499117
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29985785
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.29823283
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29098734
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28565616
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.27421699
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26689378
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26434212
87ELK1_19687146_ChIP-ChIP_HELA_Human1.24141032
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23309312
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23150765
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22906487
91* TTF2_22483619_ChIP-Seq_HELA_Human1.22855527
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22855384
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.22502284
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21351605
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19171039
96RACK7_27058665_Chip-Seq_MCF-7_Human1.17978418
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.17708535
98TFEB_21752829_ChIP-Seq_HELA_Human1.15943411
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15853377
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15466076
101* SPI1_23547873_ChIP-Seq_NB4_Human1.14843589
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14170461
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13138071
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13136540
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13074163
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12008727
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11947713
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11551269
109VDR_23849224_ChIP-Seq_CD4+_Human1.09742612
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09666147
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.09610237
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09562684
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09479821
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07795148
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07726672
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07461326
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07101588
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.05674780
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05318546
120MAF_26560356_Chip-Seq_TH1_Human1.05159662
121KDM2B_26808549_Chip-Seq_DND41_Human1.04435320
122* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03395381
123NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03108985
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02903038
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.02158879
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00843147
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00388935
128* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99868365
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99742068
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99066024
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98822715
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98448317
133* ETS1_21867929_ChIP-Seq_TH2_Mouse0.97620601
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97615747
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.97371686
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97304788
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96716522
138UTX_26944678_Chip-Seq_JUKART_Human0.93403795
139MAF_26560356_Chip-Seq_TH2_Human0.92282627
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90799442
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90051012
142NCOR1_26117541_ChIP-Seq_K562_Human0.88952433
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88285102
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87192622
145MYB_26560356_Chip-Seq_TH2_Human0.86994703
146CHD1_26751641_Chip-Seq_LNCaP_Human0.86061852
147MYB_26560356_Chip-Seq_TH1_Human0.85648631
148MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85236563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.07115303
2MP0009278_abnormal_bone_marrow3.93404354
3MP0010030_abnormal_orbit_morphology3.51091907
4MP0005171_absent_coat_pigmentation3.49871980
5MP0010094_abnormal_chromosome_stability3.20146099
6MP0004233_abnormal_muscle_weight2.99041598
7MP0004957_abnormal_blastocyst_morpholog2.80578279
8MP0003111_abnormal_nucleus_morphology2.59243684
9MP0002009_preneoplasia2.57488593
10MP0003890_abnormal_embryonic-extraembry2.35022734
11MP0003693_abnormal_embryo_hatching2.27326009
12MP0005451_abnormal_body_composition2.27130743
13MP0010352_gastrointestinal_tract_polyps2.24474311
14MP0001545_abnormal_hematopoietic_system2.19873014
15MP0005397_hematopoietic_system_phenotyp2.19873014
16MP0008995_early_reproductive_senescence2.19655195
17MP0008058_abnormal_DNA_repair2.17940823
18MP0003786_premature_aging2.15200365
19MP0003077_abnormal_cell_cycle2.12184731
20MP0003763_abnormal_thymus_physiology2.01718400
21MP0005076_abnormal_cell_differentiation1.98856507
22MP0004133_heterotaxia1.93505517
23MP0003283_abnormal_digestive_organ1.93136939
24MP0008932_abnormal_embryonic_tissue1.93005088
25MP0005174_abnormal_tail_pigmentation1.86023744
26MP0008260_abnormal_autophagy1.85684966
27MP0003119_abnormal_digestive_system1.82182980
28MP0010234_abnormal_vibrissa_follicle1.81964460
29MP0002086_abnormal_extraembryonic_tissu1.81073164
30MP0001697_abnormal_embryo_size1.80794715
31MP0002653_abnormal_ependyma_morphology1.78704512
32MP0002084_abnormal_developmental_patter1.77800078
33MP0008877_abnormal_DNA_methylation1.77650249
34MP0004808_abnormal_hematopoietic_stem1.71216696
35MP0001293_anophthalmia1.70158287
36MP0000490_abnormal_crypts_of1.69618075
37MP0004197_abnormal_fetal_growth/weight/1.68882236
38MP0002085_abnormal_embryonic_tissue1.63751520
39MP0000350_abnormal_cell_proliferation1.60150786
40MP0001835_abnormal_antigen_presentation1.59055496
41MP0001730_embryonic_growth_arrest1.58836818
42MP0001672_abnormal_embryogenesis/_devel1.56355656
43MP0005380_embryogenesis_phenotype1.56355656
44MP0001853_heart_inflammation1.55473262
45MP0002249_abnormal_larynx_morphology1.55339406
46MP0003567_abnormal_fetal_cardiomyocyte1.54707169
47MP0003453_abnormal_keratinocyte_physiol1.54466569
48MP0006072_abnormal_retinal_apoptosis1.53724626
49MP0001873_stomach_inflammation1.51208117
50MP0002282_abnormal_trachea_morphology1.51062725
51MP0002166_altered_tumor_susceptibility1.49141512
52MP0000703_abnormal_thymus_morphology1.40162857
53MP0000371_diluted_coat_color1.38052487
54MP0002398_abnormal_bone_marrow1.37109791
55MP0005075_abnormal_melanosome_morpholog1.36978088
56MP0002006_tumorigenesis1.36440331
57MP0003436_decreased_susceptibility_to1.36017212
58MP0002080_prenatal_lethality1.31069482
59MP0003984_embryonic_growth_retardation1.30472130
60MP0004185_abnormal_adipocyte_glucose1.29582613
61MP0009379_abnormal_foot_pigmentation1.28973158
62MP0001661_extended_life_span1.28756484
63MP0002088_abnormal_embryonic_growth/wei1.25460551
64MP0010307_abnormal_tumor_latency1.23982088
65MP0000537_abnormal_urethra_morphology1.23944883
66MP0000358_abnormal_cell_content/1.23901820
67MP0002019_abnormal_tumor_incidence1.23352797
68MP0006035_abnormal_mitochondrial_morpho1.22837541
69MP0002722_abnormal_immune_system1.22377035
70MP0002269_muscular_atrophy1.20786524
71MP0004947_skin_inflammation1.20182498
72MP0000858_altered_metastatic_potential1.19296628
73MP0002111_abnormal_tail_morphology1.18936180
74MP0005000_abnormal_immune_tolerance1.18373541
75MP0004264_abnormal_extraembryonic_tissu1.14346540
76MP0002429_abnormal_blood_cell1.13508989
77MP0000015_abnormal_ear_pigmentation1.12705221
78MP0003172_abnormal_lysosome_physiology1.12583200
79MP0001800_abnormal_humoral_immune1.12434599
80MP0000470_abnormal_stomach_morphology1.11942147
81MP0001849_ear_inflammation1.11670199
82MP0002396_abnormal_hematopoietic_system1.10354582
83MP0009697_abnormal_copulation1.07255930
84MP0000579_abnormal_nail_morphology1.06325591
85MP0001216_abnormal_epidermal_layer1.04817506
86MP0000313_abnormal_cell_death1.03368924
87MP0002420_abnormal_adaptive_immunity1.02223487
88MP0001819_abnormal_immune_cell1.01358196
89MP0002452_abnormal_antigen_presenting1.01168781
90MP0000716_abnormal_immune_system0.99328302
91MP0003300_gastrointestinal_ulcer0.98209485
92MP0005671_abnormal_response_to0.97936382
93MP0002796_impaired_skin_barrier0.97202307
94MP0002723_abnormal_immune_serum0.97008686
95MP0003186_abnormal_redox_activity0.95654271
96MP0008007_abnormal_cellular_replicative0.94276007
97MP0003718_maternal_effect0.92964737
98MP0002132_abnormal_respiratory_system0.92948030
99MP0001881_abnormal_mammary_gland0.92922914
100MP0000462_abnormal_digestive_system0.92656642
101MP0005058_abnormal_lysosome_morphology0.91914138
102MP0002075_abnormal_coat/hair_pigmentati0.91214168
103MP0002932_abnormal_joint_morphology0.90991475
104MP0000685_abnormal_immune_system0.89568985
105MP0003315_abnormal_perineum_morphology0.89256787
106MP0001790_abnormal_immune_system0.89120838
107MP0005387_immune_system_phenotype0.89120838
108MP0003566_abnormal_cell_adhesion0.88513070
109MP0002148_abnormal_hypersensitivity_rea0.88243842
110MP0005621_abnormal_cell_physiology0.88176540
111MP0010155_abnormal_intestine_physiology0.86639261
112MP0009333_abnormal_splenocyte_physiolog0.86584965
113MP0009053_abnormal_anal_canal0.85092209
114MP0001340_abnormal_eyelid_morphology0.85000619
115MP0006036_abnormal_mitochondrial_physio0.84771765
116MP0005384_cellular_phenotype0.84274505
117MP0001727_abnormal_embryo_implantation0.82917597
118MP0005025_abnormal_response_to0.82740780
119MP0005501_abnormal_skin_physiology0.82495046
120MP0003935_abnormal_craniofacial_develop0.82055158
121MP0005023_abnormal_wound_healing0.80913124
122MP0002114_abnormal_axial_skeleton0.80837961
123MP0003755_abnormal_palate_morphology0.80304803
124MP0000762_abnormal_tongue_morphology0.79908658
125MP0000678_abnormal_parathyroid_gland0.79592438
126MP0003705_abnormal_hypodermis_morpholog0.79492277
127MP0005266_abnormal_metabolism0.79168226
128MP0000639_abnormal_adrenal_gland0.78644930
129MP0001145_abnormal_male_reproductive0.78451842
130MP0009931_abnormal_skin_appearance0.77200042
131MP0003656_abnormal_erythrocyte_physiolo0.75189491
132MP0000377_abnormal_hair_follicle0.75072616
133MP0002060_abnormal_skin_morphology0.74582409
134MP0001186_pigmentation_phenotype0.73268764
135MP0002405_respiratory_system_inflammati0.73254823
136MP0000432_abnormal_head_morphology0.72987632
137MP0000477_abnormal_intestine_morphology0.71962611
138MP0003828_pulmonary_edema0.71040541
139MP0002116_abnormal_craniofacial_bone0.68796250
140MP0009115_abnormal_fat_cell0.68503529
141MP0000689_abnormal_spleen_morphology0.67276070
142MP0010630_abnormal_cardiac_muscle0.65302537
143MP0003806_abnormal_nucleotide_metabolis0.64665411
144MP0001915_intracranial_hemorrhage0.64125098
145MP0003221_abnormal_cardiomyocyte_apopto0.63394297
146MP0000516_abnormal_urinary_system0.62360950
147MP0005367_renal/urinary_system_phenotyp0.62360950
148MP0002697_abnormal_eye_size0.62018767
149MP0002877_abnormal_melanocyte_morpholog0.60413497
150MP0000467_abnormal_esophagus_morphology0.60265118
151MP0002210_abnormal_sex_determination0.60246099

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.27787213
2Facial hemangioma (HP:0000329)4.94434859
3Microvesicular hepatic steatosis (HP:0001414)4.63829956
4Pustule (HP:0200039)4.61178079
5Concave nail (HP:0001598)4.60571250
6Annular pancreas (HP:0001734)4.55126257
7Rectovaginal fistula (HP:0000143)4.53072715
8Rectal fistula (HP:0100590)4.53072715
9Poikiloderma (HP:0001029)4.44563102
10Reticulocytopenia (HP:0001896)4.28203493
11Tongue fasciculations (HP:0001308)4.14427419
12Ulnar bowing (HP:0003031)4.10174533
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.06652437
14Vaginal fistula (HP:0004320)4.05652678
15Alopecia of scalp (HP:0002293)4.04548071
16Intestinal fistula (HP:0100819)4.03535374
17Increased IgM level (HP:0003496)3.97656751
18Muscle fibrillation (HP:0010546)3.82714490
19Turricephaly (HP:0000262)3.80831128
20Hypochromic microcytic anemia (HP:0004840)3.80648435
21Short humerus (HP:0005792)3.78430068
22Aplasia/hypoplasia of the humerus (HP:0006507)3.72635863
23Abnormality of cells of the erythroid lineage (HP:0012130)3.67384636
24Selective tooth agenesis (HP:0001592)3.53311996
25Orthostatic hypotension (HP:0001278)3.51640308
26Abnormal hemoglobin (HP:0011902)3.41919999
27Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.41608954
28Vertebral hypoplasia (HP:0008417)3.41608954
29Absent radius (HP:0003974)3.38620542
30Squamous cell carcinoma (HP:0002860)3.34600157
31Intestinal atresia (HP:0011100)3.34465552
32Coronal craniosynostosis (HP:0004440)3.31805027
33Absent thumb (HP:0009777)3.21594892
34Male infertility (HP:0003251)3.16811488
35Absent forearm bone (HP:0003953)3.16607822
36Aplasia involving forearm bones (HP:0009822)3.16607822
37Macrocytic anemia (HP:0001972)3.16022113
38Basal cell carcinoma (HP:0002671)3.15380788
39Progressive muscle weakness (HP:0003323)3.08898635
40Volvulus (HP:0002580)3.06201802
41Broad alveolar ridges (HP:0000187)3.05875020
42Congenital hip dislocation (HP:0001374)3.04580271
43Patellar aplasia (HP:0006443)3.02377502
44Trismus (HP:0000211)2.98689815
45Abnormal number of erythroid precursors (HP:0012131)2.94263012
46Anteriorly placed anus (HP:0001545)2.90287049
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84484831
48Abnormality of male internal genitalia (HP:0000022)2.83831487
49Short chin (HP:0000331)2.83562256
50Cholecystitis (HP:0001082)2.81914091
51Abnormal gallbladder physiology (HP:0012438)2.81914091
52Aplastic anemia (HP:0001915)2.79608692
53Dysautonomia (HP:0002459)2.79417548
54Alacrima (HP:0000522)2.77855296
55Aplasia/Hypoplasia of the patella (HP:0006498)2.77553529
56Albinism (HP:0001022)2.74421428
57Ragged-red muscle fibers (HP:0003200)2.74080688
58Premature graying of hair (HP:0002216)2.72463405
59IgM deficiency (HP:0002850)2.71396183
60Abnormality of the aortic arch (HP:0012303)2.70785803
61Premature skin wrinkling (HP:0100678)2.69271409
62Abnormality of glycolysis (HP:0004366)2.69164341
63Pallor (HP:0000980)2.67141263
64Progressive external ophthalmoplegia (HP:0000590)2.66275860
65Multiple enchondromatosis (HP:0005701)2.59780420
66Pancreatic islet-cell hyperplasia (HP:0004510)2.56994088
67Chromsome breakage (HP:0040012)2.56431155
68Rough bone trabeculation (HP:0100670)2.54565940
69Abnormality of the labia minora (HP:0012880)2.54054156
70Large for gestational age (HP:0001520)2.53529105
71Diaphragmatic weakness (HP:0009113)2.51973583
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49828820
73Urinary glycosaminoglycan excretion (HP:0003541)2.49739525
74Mucopolysacchariduria (HP:0008155)2.49739525
75IgA deficiency (HP:0002720)2.47514982
76Hypotelorism (HP:0000601)2.47075014
77Astrocytoma (HP:0009592)2.46097997
78Abnormality of the astrocytes (HP:0100707)2.46097997
79Recurrent viral infections (HP:0004429)2.44301008
80Bifid uvula (HP:0000193)2.43027592
81Fatigue (HP:0012378)2.40594453
82Hypochromic anemia (HP:0001931)2.39921597
83Hamartoma (HP:0010566)2.39738404
84Joint stiffness (HP:0001387)2.39211806
85Hypotrichosis (HP:0001006)2.36623198
86Thrombocytosis (HP:0001894)2.35030506
87Abnormal number of incisors (HP:0011064)2.32569475
88Vertebral fusion (HP:0002948)2.31991613
89Capillary hemangiomas (HP:0005306)2.31699428
90Abnormality of reticulocytes (HP:0004312)2.29911559
91Cerebral aneurysm (HP:0004944)2.29731311
92Entropion (HP:0000621)2.28640980
93Deep philtrum (HP:0002002)2.27872230
94Bowing of the arm (HP:0006488)2.27446904
95Bowed forearm bones (HP:0003956)2.27446904
96Choanal stenosis (HP:0000452)2.25913091
97Abnormality of T cell physiology (HP:0011840)2.24801569
98Increased number of teeth (HP:0011069)2.22954249
99Growth hormone excess (HP:0000845)2.21433401
100Abnormality of the umbilical cord (HP:0010881)2.21158485
101Spinal muscular atrophy (HP:0007269)2.20236327
102Acute lymphatic leukemia (HP:0006721)2.19377223
103Aplasia of the musculature (HP:0100854)2.19327486
104Panhypogammaglobulinemia (HP:0003139)2.19222723
105Hypoplasia of the radius (HP:0002984)2.18679138
106Decreased lacrimation (HP:0000633)2.17113421
107Degeneration of anterior horn cells (HP:0002398)2.15122515
108Abnormality of the anterior horn cell (HP:0006802)2.15122515
109Increased serum pyruvate (HP:0003542)2.14634539
110Agammaglobulinemia (HP:0004432)2.14633862
111Vertebral compression fractures (HP:0002953)2.14479638
112Abnormality of polysaccharide metabolism (HP:0011012)2.14246354
113Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14246354
114Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14246354
115Neoplasm of the oral cavity (HP:0100649)2.13869733
116Gastrointestinal atresia (HP:0002589)2.13373872
117Muscle fiber atrophy (HP:0100295)2.12403711
118Polycythemia (HP:0001901)2.12053492
119Ependymoma (HP:0002888)2.11452071
120Hypertensive crisis (HP:0100735)2.09139036
121Dysostosis multiplex (HP:0000943)2.08143717
122Oral leukoplakia (HP:0002745)2.07311566
123Split hand (HP:0001171)2.05359083
124Pancytopenia (HP:0001876)2.04273833
125Myelodysplasia (HP:0002863)2.03384000
126Abnormality of the preputium (HP:0100587)2.02440291
127Premature ovarian failure (HP:0008209)2.02081978
128Short 5th finger (HP:0009237)1.98395343
129Aplasia/Hypoplasia of the thymus (HP:0010515)1.97737899
130Abnormality of the distal phalanges of the toes (HP:0010182)1.95001677
131Lymphoma (HP:0002665)1.93144913
132Hypokinesia (HP:0002375)1.92608392
133Breast hypoplasia (HP:0003187)1.91534086
134Autoimmune hemolytic anemia (HP:0001890)1.89962399
135Seborrheic dermatitis (HP:0001051)1.89776565
136Clumsiness (HP:0002312)1.89383023
137Proximal placement of thumb (HP:0009623)1.89314209
138Deviation of the thumb (HP:0009603)1.88149469
139Type 2 muscle fiber atrophy (HP:0003554)1.87835386
140Popliteal pterygium (HP:0009756)1.87609096
141Abnormality of oral frenula (HP:0000190)1.87143104
142Glioma (HP:0009733)1.87058081
143Abnormality of the fetal cardiovascular system (HP:0010948)1.86903144
144Abnormal umbilical cord blood vessels (HP:0011403)1.86903144
145Single umbilical artery (HP:0001195)1.86903144
146Granulocytopenia (HP:0001913)1.86430745
147Respiratory difficulties (HP:0002880)1.86075448
148Generalized amyotrophy (HP:0003700)1.85733104
149Testicular atrophy (HP:0000029)1.85622149
150Ankyloglossia (HP:0010296)1.85090640
151Abnormality of the ileum (HP:0001549)1.84796121
152Bulbar palsy (HP:0001283)1.84190643
153Redundant skin (HP:0001582)1.83963815
154Abnormal trabecular bone morphology (HP:0100671)1.83826067
155Increased serum lactate (HP:0002151)1.80702945
156Cutaneous melanoma (HP:0012056)1.80549979
15711 pairs of ribs (HP:0000878)1.79818119
158B lymphocytopenia (HP:0010976)1.79743312
159Hemivertebrae (HP:0002937)1.79262076
160Short thumb (HP:0009778)1.78904518
161Abnormalities of placenta or umbilical cord (HP:0001194)1.78230279
162Sparse eyelashes (HP:0000653)1.76677390
163Broad distal phalanx of finger (HP:0009836)1.75344469
164Hyperacusis (HP:0010780)1.73610609
165Viral hepatitis (HP:0006562)1.73299825
166Villous atrophy (HP:0011473)1.72835734
167Abnormality of small intestinal villus morphology (HP:0011472)1.72835734
168Colitis (HP:0002583)1.71371885
169Cellulitis (HP:0100658)1.71093661
170Secondary amenorrhea (HP:0000869)1.69809380
171Rhabdomyolysis (HP:0003201)1.69767170
172Combined immunodeficiency (HP:0005387)1.68664743
173Horseshoe kidney (HP:0000085)1.67882716
174Spastic diplegia (HP:0001264)1.66955148
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65495623
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65495623
177Pili torti (HP:0003777)1.65203622
178Birth length less than 3rd percentile (HP:0003561)1.64210819
179Abnormality of T cells (HP:0002843)1.64043238
180Septate vagina (HP:0001153)1.63087604
181Abnormality of cells of the lymphoid lineage (HP:0012140)1.62357076
182Ridged nail (HP:0001807)1.62293165
183Gastrointestinal stroma tumor (HP:0100723)1.62086252
184Abnormal delayed hypersensitivity skin test (HP:0002963)1.61789448
185Increased intramyocellular lipid droplets (HP:0012240)1.61158294
186Type I transferrin isoform profile (HP:0003642)1.59237550
187Short nail (HP:0001799)1.58757966
188Sparse lateral eyebrow (HP:0005338)1.58341414
189Hypergonadotropic hypogonadism (HP:0000815)1.57084333
190Carpal bone hypoplasia (HP:0001498)1.56894291
191Hepatosplenomegaly (HP:0001433)1.56142510
192Cellular immunodeficiency (HP:0005374)1.52747227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.63127798
2DDR24.71853167
3MAPK154.36592651
4MAP3K64.17861071
5PBK3.43554795
6MAP3K113.36696151
7SMG13.02402841
8MATK2.98487363
9SRPK12.90958945
10TYRO32.66805615
11PINK12.62260572
12FGR2.60070390
13VRK22.53619193
14PIM22.51255172
15DAPK12.31374175
16SCYL22.17510314
17BMX2.11781932
18EIF2AK12.09138724
19TSSK62.08715469
20UHMK12.07231407
21IRAK32.01345278
22PDGFRA1.98923094
23CDK71.97963090
24CSK1.92016927
25PRKD21.91421616
26PASK1.83963838
27YES11.83915454
28DYRK1B1.79275140
29STK161.75591968
30EIF2AK31.66179292
31PIM11.55764298
32CDK61.55458145
33NME11.54155953
34LATS21.48542249
35MAP3K101.46913592
36TRPM71.37608541
37CDC71.37060180
38WEE11.36622656
39AKT31.33069461
40MST1R1.26676994
41BUB11.24931536
42RPS6KC11.24500350
43RPS6KL11.24500350
44PLK11.23355861
45DYRK31.19663066
46CHEK21.19408414
47MAP3K141.13278655
48RPS6KB21.09992256
49RPS6KA61.08663786
50ZAK1.08495237
51LRRK21.06972760
52MAP2K31.03835523
53MAPK111.03612686
54GSK3A1.02187315
55PDK21.01974499
56NEK21.00373930
57STK30.99922422
58CDC42BPA0.98963417
59EPHA20.93984772
60ATR0.93576992
61CDK120.92944638
62MST40.89152923
63MTOR0.88998866
64KDR0.87687806
65MKNK10.86348230
66PLK30.85763601
67TRIB30.85445899
68STK100.83705746
69PLK40.79987013
70TAOK20.79635764
71VRK10.79166870
72BCKDK0.76435322
73RPS6KA40.75716237
74NEK10.75299080
75CDK190.75146081
76MAP3K130.72926543
77ERN10.72678155
78TBK10.71817733
79RPS6KA10.71452963
80TTK0.69785899
81CDK20.66410907
82BRD40.65612416
83STK40.65210352
84PHKG20.64085260
85PHKG10.64085260
86BRAF0.63772238
87CLK10.63448588
88BRSK20.63424135
89CDK40.62545681
90IRAK40.62511811
91CDK90.62247177
92HIPK20.62076068
93SIK30.61958945
94FLT30.61533896
95AURKA0.61324262
96CHEK10.59217454
97AURKB0.58683560
98JAK30.58586986
99ILK0.57504137
100ALK0.54392493
101RAF10.53747491
102BTK0.52956344
103ACVR1B0.52913123
104KSR20.52832188
105CSNK2A10.52365224
106EIF2AK20.50691381
107PRKAA10.50349442
108MAP3K80.49557471
109AKT20.48738720
110ATM0.46959241
111PKN20.46436329
112ARAF0.46186675
113TAF10.44872192
114RPS6KB10.44600497
115FGFR40.44030461
116CSNK2A20.43746210
117CCNB10.41943436
118EGFR0.40838795
119MAP2K20.40469587
120PAK40.40052670
121RIPK40.39054617
122MAPK10.38956576
123SIK10.37556725
124TGFBR10.37086376
125TESK20.36701302
126MAPK30.35686491
127PAK20.35674910
128PRPF4B0.35416166
129IKBKB0.35222268
130FES0.35043258
131PAK10.35025728
132CDK10.34907456
133LYN0.34161715
134MAPKAPK30.33742009
135EEF2K0.33728183
136PDGFRB0.33127692
137NME20.32815682
138MAPK140.32252009
139MAPKAPK20.30484850
140ERBB30.29467461
141FGFR10.27557344
142BRSK10.27347752
143MAPK100.25639455
144MAPK40.24357146
145DYRK20.23868713
146CSNK1G10.22902653
147PRKCI0.22197072
148PTK20.21234511
149TLK10.20901720
150MAP4K10.20755160
151CDK80.20601865
152TAOK10.19872100
153INSR0.19495165
154RIPK10.18189590

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.19135451
2Base excision repair_Homo sapiens_hsa034104.59278615
3DNA replication_Homo sapiens_hsa030304.56578942
4Fatty acid biosynthesis_Homo sapiens_hsa000614.11218109
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97794150
6Nucleotide excision repair_Homo sapiens_hsa034202.70226892
7Spliceosome_Homo sapiens_hsa030402.69257010
8* RNA transport_Homo sapiens_hsa030132.40449205
9Homologous recombination_Homo sapiens_hsa034402.34914884
10mRNA surveillance pathway_Homo sapiens_hsa030152.13181218
11Cell cycle_Homo sapiens_hsa041102.05978762
12Fanconi anemia pathway_Homo sapiens_hsa034601.93306437
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90939413
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79654304
15Ribosome_Homo sapiens_hsa030101.79151124
16p53 signaling pathway_Homo sapiens_hsa041151.75612113
17One carbon pool by folate_Homo sapiens_hsa006701.71529355
18Hippo signaling pathway_Homo sapiens_hsa043901.71011826
19Notch signaling pathway_Homo sapiens_hsa043301.64635085
20mTOR signaling pathway_Homo sapiens_hsa041501.62745382
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61573592
22Biosynthesis of amino acids_Homo sapiens_hsa012301.60178817
23Hedgehog signaling pathway_Homo sapiens_hsa043401.48368832
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47799838
25Arginine and proline metabolism_Homo sapiens_hsa003301.44074293
26Carbon metabolism_Homo sapiens_hsa012001.38043268
27Sulfur relay system_Homo sapiens_hsa041221.36356369
28Adherens junction_Homo sapiens_hsa045201.34445357
29Circadian rhythm_Homo sapiens_hsa047101.32185543
30Proteasome_Homo sapiens_hsa030501.32071267
31RNA polymerase_Homo sapiens_hsa030201.27178489
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24587833
33TGF-beta signaling pathway_Homo sapiens_hsa043501.18815353
34Allograft rejection_Homo sapiens_hsa053301.17647857
35Bladder cancer_Homo sapiens_hsa052191.17451623
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16942075
37Folate biosynthesis_Homo sapiens_hsa007901.14188559
38Other glycan degradation_Homo sapiens_hsa005111.10533579
39Autoimmune thyroid disease_Homo sapiens_hsa053201.10036473
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06353218
41Antigen processing and presentation_Homo sapiens_hsa046121.05651707
42Shigellosis_Homo sapiens_hsa051311.04292959
43Oocyte meiosis_Homo sapiens_hsa041141.00939274
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98592635
45Basal cell carcinoma_Homo sapiens_hsa052170.97301985
46Purine metabolism_Homo sapiens_hsa002300.96272114
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95434922
48Pyrimidine metabolism_Homo sapiens_hsa002400.95304966
49Asthma_Homo sapiens_hsa053100.92991013
50Fructose and mannose metabolism_Homo sapiens_hsa000510.89212297
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87812170
52Lysine degradation_Homo sapiens_hsa003100.87430477
53Viral carcinogenesis_Homo sapiens_hsa052030.86935890
54Measles_Homo sapiens_hsa051620.86851857
55Wnt signaling pathway_Homo sapiens_hsa043100.86824718
56Colorectal cancer_Homo sapiens_hsa052100.86802179
57RNA degradation_Homo sapiens_hsa030180.85273013
58Basal transcription factors_Homo sapiens_hsa030220.81917018
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81473677
60Fatty acid metabolism_Homo sapiens_hsa012120.80987192
61MicroRNAs in cancer_Homo sapiens_hsa052060.80476859
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78859947
63Systemic lupus erythematosus_Homo sapiens_hsa053220.78290957
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77929018
65Primary immunodeficiency_Homo sapiens_hsa053400.76170048
66Graft-versus-host disease_Homo sapiens_hsa053320.75339612
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.74683743
68Leishmaniasis_Homo sapiens_hsa051400.73518173
69Epstein-Barr virus infection_Homo sapiens_hsa051690.73417784
70Non-small cell lung cancer_Homo sapiens_hsa052230.72995192
71VEGF signaling pathway_Homo sapiens_hsa043700.72487799
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.71962572
73Thyroid cancer_Homo sapiens_hsa052160.71923991
74Influenza A_Homo sapiens_hsa051640.69231293
75Chronic myeloid leukemia_Homo sapiens_hsa052200.69141873
76Small cell lung cancer_Homo sapiens_hsa052220.68094465
77Legionellosis_Homo sapiens_hsa051340.66861667
78B cell receptor signaling pathway_Homo sapiens_hsa046620.65061828
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64917371
80Pyruvate metabolism_Homo sapiens_hsa006200.64046929
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61570868
82Acute myeloid leukemia_Homo sapiens_hsa052210.61528208
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57430660
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57385501
85Selenocompound metabolism_Homo sapiens_hsa004500.57274894
86Viral myocarditis_Homo sapiens_hsa054160.56924874
87Galactose metabolism_Homo sapiens_hsa000520.54991632
88Herpes simplex infection_Homo sapiens_hsa051680.54927090
89Non-homologous end-joining_Homo sapiens_hsa034500.52646794
90Protein export_Homo sapiens_hsa030600.52462226
91Tight junction_Homo sapiens_hsa045300.51969629
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51800554
93Fatty acid elongation_Homo sapiens_hsa000620.51656791
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.51507567
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50589699
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.50204072
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49727644
98HTLV-I infection_Homo sapiens_hsa051660.49452622
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.49240804
100Type I diabetes mellitus_Homo sapiens_hsa049400.47257172
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46529908
102Glutathione metabolism_Homo sapiens_hsa004800.46090396
103T cell receptor signaling pathway_Homo sapiens_hsa046600.44463678
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.42502486
105Huntingtons disease_Homo sapiens_hsa050160.42346231
106Toxoplasmosis_Homo sapiens_hsa051450.41844715
107AMPK signaling pathway_Homo sapiens_hsa041520.41082895
108Parkinsons disease_Homo sapiens_hsa050120.36924775
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.35552891
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35276499
111Arginine biosynthesis_Homo sapiens_hsa002200.34931969
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.34604872
113Proteoglycans in cancer_Homo sapiens_hsa052050.33840325
114Hepatitis B_Homo sapiens_hsa051610.33424064
115Hematopoietic cell lineage_Homo sapiens_hsa046400.32991751
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32321838
117N-Glycan biosynthesis_Homo sapiens_hsa005100.32053774
118Insulin signaling pathway_Homo sapiens_hsa049100.31425074
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31018743
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30496328
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29297494
122Endometrial cancer_Homo sapiens_hsa052130.28532063
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27419082
124Hepatitis C_Homo sapiens_hsa051600.27358323
125ErbB signaling pathway_Homo sapiens_hsa040120.27220403
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25774994
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25710659
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25372272
129Pathways in cancer_Homo sapiens_hsa052000.24378518
130Apoptosis_Homo sapiens_hsa042100.23910284
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23741933
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23217892
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22596135
134HIF-1 signaling pathway_Homo sapiens_hsa040660.22012476
135Gap junction_Homo sapiens_hsa045400.21746569
136Prostate cancer_Homo sapiens_hsa052150.20862740
137Choline metabolism in cancer_Homo sapiens_hsa052310.20777048
138Dorso-ventral axis formation_Homo sapiens_hsa043200.19362299
139Pancreatic cancer_Homo sapiens_hsa052120.16978591
140Pentose phosphate pathway_Homo sapiens_hsa000300.16050283

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