EIF3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.25234635
2maturation of SSU-rRNA (GO:0030490)5.05418366
3viral transcription (GO:0019083)5.01307004
4translational termination (GO:0006415)4.93643878
5ribosomal small subunit biogenesis (GO:0042274)4.59021518
6* formation of translation preinitiation complex (GO:0001731)4.43780026
7translational elongation (GO:0006414)4.42300623
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32409649
9ribosomal large subunit biogenesis (GO:0042273)4.23877867
10cotranslational protein targeting to membrane (GO:0006613)4.22141296
11protein targeting to ER (GO:0045047)4.20092164
12* translational initiation (GO:0006413)4.12823876
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07557099
14DNA strand elongation involved in DNA replication (GO:0006271)4.06254908
15establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98844811
16protein localization to endoplasmic reticulum (GO:0070972)3.94376864
17DNA unwinding involved in DNA replication (GO:0006268)3.94008972
18DNA strand elongation (GO:0022616)3.87711454
19viral life cycle (GO:0019058)3.86378450
20cellular protein complex disassembly (GO:0043624)3.84993451
21telomere maintenance via semi-conservative replication (GO:0032201)3.84755516
22DNA replication initiation (GO:0006270)3.81555155
23ribonucleoprotein complex biogenesis (GO:0022613)3.76334213
24non-recombinational repair (GO:0000726)3.71835059
25double-strand break repair via nonhomologous end joining (GO:0006303)3.71835059
26mitotic sister chromatid cohesion (GO:0007064)3.65139214
27regulation of centriole replication (GO:0046599)3.63363476
28telomere maintenance via recombination (GO:0000722)3.62002573
29pore complex assembly (GO:0046931)3.61726729
30CENP-A containing nucleosome assembly (GO:0034080)3.57723609
31nucleobase biosynthetic process (GO:0046112)3.51463314
32IMP biosynthetic process (GO:0006188)3.50934593
33mitotic recombination (GO:0006312)3.50372864
34chromatin remodeling at centromere (GO:0031055)3.47381373
35protein complex disassembly (GO:0043241)3.44033631
36purine nucleobase biosynthetic process (GO:0009113)3.43385346
37negative regulation of DNA repair (GO:0045738)3.42881883
38nuclear pore organization (GO:0006999)3.38705208
39sister chromatid segregation (GO:0000819)3.37954233
40DNA ligation (GO:0006266)3.37430975
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.36712036
42regulation of helicase activity (GO:0051095)3.36055516
43protein localization to kinetochore (GO:0034501)3.30963056
44ribosome biogenesis (GO:0042254)3.30663737
45mitotic nuclear envelope disassembly (GO:0007077)3.28576438
46viral mRNA export from host cell nucleus (GO:0046784)3.28075420
47* nuclear-transcribed mRNA catabolic process (GO:0000956)3.27652004
48kinetochore organization (GO:0051383)3.27643661
49rRNA processing (GO:0006364)3.27137692
50proteasome assembly (GO:0043248)3.27058515
51IMP metabolic process (GO:0046040)3.27045059
52regulation of translational fidelity (GO:0006450)3.26457402
53DNA replication-independent nucleosome assembly (GO:0006336)3.26064506
54DNA replication-independent nucleosome organization (GO:0034724)3.26064506
55macromolecular complex disassembly (GO:0032984)3.26059157
56establishment of viral latency (GO:0019043)3.25758642
57attachment of spindle microtubules to kinetochore (GO:0008608)3.25215542
58nuclear pore complex assembly (GO:0051292)3.22724647
59* translation (GO:0006412)3.22013071
60mitotic metaphase plate congression (GO:0007080)3.20665740
61mitotic sister chromatid segregation (GO:0000070)3.20405186
62mitotic spindle checkpoint (GO:0071174)3.19542425
63tRNA aminoacylation for protein translation (GO:0006418)3.19211975
64spindle checkpoint (GO:0031577)3.14806222
65rRNA metabolic process (GO:0016072)3.14300902
66tRNA aminoacylation (GO:0043039)3.13678583
67amino acid activation (GO:0043038)3.13678583
68telomere maintenance via telomere lengthening (GO:0010833)3.11669480
69* mRNA catabolic process (GO:0006402)3.11477070
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.10001397
71negative regulation of sister chromatid segregation (GO:0033046)3.10001397
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10001397
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10001397
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10001397
75ribosome assembly (GO:0042255)3.07915424
76mitotic G2/M transition checkpoint (GO:0044818)3.06919414
77negative regulation of chromosome segregation (GO:0051985)3.06550808
78DNA replication checkpoint (GO:0000076)3.06389022
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.06005639
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05954182
81DNA replication-dependent nucleosome assembly (GO:0006335)3.03090008
82DNA replication-dependent nucleosome organization (GO:0034723)3.03090008
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03014437
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03014437
85nuclear envelope disassembly (GO:0051081)3.02445061
86membrane disassembly (GO:0030397)3.02445061
87* RNA catabolic process (GO:0006401)3.00742559
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98266007
89regulation of chromosome segregation (GO:0051983)2.98002582
90metaphase plate congression (GO:0051310)2.97642236
91regulation of mitotic sister chromatid separation (GO:0010965)2.97381261
92regulation of mitotic sister chromatid segregation (GO:0033047)2.97381261
93regulation of sister chromatid segregation (GO:0033045)2.97381261
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96364338
95mitotic spindle assembly checkpoint (GO:0007094)2.93946672
96spliceosomal snRNP assembly (GO:0000387)2.92687916
97positive regulation of chromosome segregation (GO:0051984)2.92448362
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90905395
99DNA geometric change (GO:0032392)2.90316278
100spindle assembly checkpoint (GO:0071173)2.89287393
101histone exchange (GO:0043486)2.83857105
102folic acid-containing compound biosynthetic process (GO:0009396)2.83117812
103DNA deamination (GO:0045006)2.82377084
104establishment of chromosome localization (GO:0051303)2.82231109
105protein localization to chromosome, centromeric region (GO:0071459)2.78993705
106negative regulation of ligase activity (GO:0051352)2.77552460
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77552460
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76460807
109cell cycle G1/S phase transition (GO:0044843)2.75666434
110G1/S transition of mitotic cell cycle (GO:0000082)2.75666434
111cellular component biogenesis (GO:0044085)2.75033708
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74484658
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74484658
114establishment of integrated proviral latency (GO:0075713)2.74320300
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72295844
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72295844
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72295844
118kinetochore assembly (GO:0051382)2.71714264
119mitotic chromosome condensation (GO:0007076)2.71144133
120protein targeting to membrane (GO:0006612)2.71101128
121transcription-coupled nucleotide-excision repair (GO:0006283)2.68720734
122rRNA modification (GO:0000154)2.68626652
123pseudouridine synthesis (GO:0001522)2.68317858
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.68195396
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68195396
126regulation of spindle organization (GO:0090224)2.67160571
127termination of RNA polymerase I transcription (GO:0006363)2.66198417
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65381711
129spliceosomal complex assembly (GO:0000245)2.64892908
130maturation of 5.8S rRNA (GO:0000460)2.64469249
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.64280038
132telomere maintenance (GO:0000723)2.64198220
133DNA topological change (GO:0006265)2.63887987
134DNA duplex unwinding (GO:0032508)2.63790623
135telomere organization (GO:0032200)2.63033649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88525280
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37509998
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64875627
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46196920
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.23619251
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14589077
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.11987881
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11821767
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93805519
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88895691
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75995290
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65014399
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.64759561
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59023419
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58972477
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46210065
17* VDR_23849224_ChIP-Seq_CD4+_Human2.42382698
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38010431
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36291417
20ELK1_19687146_ChIP-ChIP_HELA_Human2.31538377
21* XRN2_22483619_ChIP-Seq_HELA_Human2.28832154
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28554872
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.19524143
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08439288
25FOXP3_21729870_ChIP-Seq_TREG_Human2.05254704
26AR_21909140_ChIP-Seq_LNCAP_Human2.02113736
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01348946
28* DCP1A_22483619_ChIP-Seq_HELA_Human1.99975403
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98565647
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97415539
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89017373
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88695701
33TTF2_22483619_ChIP-Seq_HELA_Human1.87989917
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86140144
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84874926
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.84602136
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81340445
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80593642
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79502884
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78467863
41GABP_19822575_ChIP-Seq_HepG2_Human1.74050100
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68289780
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67516529
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66855395
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66168828
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61414031
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59892179
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56236042
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55309498
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55059973
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53155670
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51991396
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51287627
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48873324
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47597033
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47394335
57MYC_22102868_ChIP-Seq_BL_Human1.47387500
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.46693436
59FUS_26573619_Chip-Seq_HEK293_Human1.46444554
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44813250
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43956325
62EWS_26573619_Chip-Seq_HEK293_Human1.43928948
63CIITA_25753668_ChIP-Seq_RAJI_Human1.41519244
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40630643
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35678511
66KDM5A_27292631_Chip-Seq_BREAST_Human1.28108684
67SPI1_23547873_ChIP-Seq_NB4_Human1.25952705
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23592511
69* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23122482
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21438679
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21438679
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21438679
73TFEB_21752829_ChIP-Seq_HELA_Human1.21082993
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.20315902
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19512760
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.16857415
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11631378
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11278342
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.10914687
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10691576
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.10489496
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.06731314
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06381457
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05611634
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.05583188
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05179995
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04528714
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03783007
89MYC_18940864_ChIP-ChIP_HL60_Human1.02711535
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02075309
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01478503
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99540106
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99475250
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98452730
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98180560
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.96958830
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96844438
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96339652
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95490301
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90737188
101MYB_26560356_Chip-Seq_TH2_Human0.90542004
102CHD1_26751641_Chip-Seq_LNCaP_Human0.89319421
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88566847
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87638426
105ELF5_23300383_ChIP-Seq_T47D_Human0.87613508
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86043107
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85470962
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84683371
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.84196623
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.81808470
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81175174
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80112538
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.80073261
114MYB_26560356_Chip-Seq_TH1_Human0.78909630
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78564352
116SCL_19346495_ChIP-Seq_HPC-7_Human0.77703941
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77077418
118GATA1_22025678_ChIP-Seq_K562_Human0.77071387
119VDR_21846776_ChIP-Seq_THP-1_Human0.76153087
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.74890060
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73021573
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72367357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.17125315
2MP0004957_abnormal_blastocyst_morpholog3.61405569
3MP0010094_abnormal_chromosome_stability3.54412046
4MP0008057_abnormal_DNA_replication3.24745917
5MP0003077_abnormal_cell_cycle3.24588685
6MP0003111_abnormal_nucleus_morphology3.10493873
7MP0008058_abnormal_DNA_repair2.72379301
8MP0002396_abnormal_hematopoietic_system2.66861024
9MP0008007_abnormal_cellular_replicative2.63769168
10MP0010352_gastrointestinal_tract_polyps2.31012268
11MP0006054_spinal_hemorrhage2.15340125
12MP0004808_abnormal_hematopoietic_stem2.00067129
13MP0008932_abnormal_embryonic_tissue1.97928096
14MP0003763_abnormal_thymus_physiology1.91925976
15MP0003123_paternal_imprinting1.89859592
16MP0001835_abnormal_antigen_presentation1.78760144
17MP0009333_abnormal_splenocyte_physiolog1.76760720
18MP0000350_abnormal_cell_proliferation1.73068199
19MP0003786_premature_aging1.72675250
20MP0000490_abnormal_crypts_of1.70810202
21MP0003890_abnormal_embryonic-extraembry1.68134577
22MP0010307_abnormal_tumor_latency1.66871044
23MP0001730_embryonic_growth_arrest1.65794789
24MP0009672_abnormal_birth_weight1.51957905
25MP0002398_abnormal_bone_marrow1.47491180
26MP0001188_hyperpigmentation1.46073744
27MP0005671_abnormal_response_to1.45679339
28MP0005397_hematopoietic_system_phenotyp1.39287387
29MP0001545_abnormal_hematopoietic_system1.39287387
30MP0002019_abnormal_tumor_incidence1.38785033
31MP0003567_abnormal_fetal_cardiomyocyte1.37956378
32MP0003937_abnormal_limbs/digits/tail_de1.36818649
33MP0009379_abnormal_foot_pigmentation1.36410707
34MP0002166_altered_tumor_susceptibility1.35324854
35MP0002006_tumorigenesis1.32444737
36MP0009697_abnormal_copulation1.29330119
37MP0000703_abnormal_thymus_morphology1.28439425
38MP0008995_early_reproductive_senescence1.27988205
39MP0002722_abnormal_immune_system1.27346389
40MP0001697_abnormal_embryo_size1.26925008
41MP0000685_abnormal_immune_system1.25190643
42MP0010234_abnormal_vibrissa_follicle1.22843806
43MP0000689_abnormal_spleen_morphology1.22463019
44MP0000313_abnormal_cell_death1.20032694
45MP0009785_altered_susceptibility_to1.19742153
46MP0001800_abnormal_humoral_immune1.19305635
47MP0005380_embryogenesis_phenotype1.19245503
48MP0001672_abnormal_embryogenesis/_devel1.19245503
49MP0004197_abnormal_fetal_growth/weight/1.18035859
50MP0002080_prenatal_lethality1.16551692
51MP0004264_abnormal_extraembryonic_tissu1.16336589
52MP0001286_abnormal_eye_development1.16088155
53MP0002429_abnormal_blood_cell1.14830567
54MP0003186_abnormal_redox_activity1.14625765
55MP0003984_embryonic_growth_retardation1.14530580
56MP0001853_heart_inflammation1.12853533
57MP0002088_abnormal_embryonic_growth/wei1.11821900
58MP0009703_decreased_birth_body1.11066822
59MP0002420_abnormal_adaptive_immunity1.11059435
60MP0006292_abnormal_olfactory_placode1.10951871
61MP0002452_abnormal_antigen_presenting1.10789214
62MP0000716_abnormal_immune_system1.10661731
63MP0001819_abnormal_immune_cell1.08700992
64MP0010030_abnormal_orbit_morphology1.08566281
65MP0008438_abnormal_cutaneous_collagen1.08066037
66MP0000858_altered_metastatic_potential1.07630780
67MP0002697_abnormal_eye_size1.07159708
68MP0005075_abnormal_melanosome_morpholog1.06840597
69MP0002086_abnormal_extraembryonic_tissu1.05951257
70MP0002796_impaired_skin_barrier1.03536385
71MP0006035_abnormal_mitochondrial_morpho1.02428925
72MP0001661_extended_life_span1.02176906
73MP0001873_stomach_inflammation1.00981859
74MP0002405_respiratory_system_inflammati0.99337250
75MP0003121_genomic_imprinting0.99144543
76MP0005023_abnormal_wound_healing0.98130835
77MP0002085_abnormal_embryonic_tissue0.96866101
78MP0002723_abnormal_immune_serum0.95380952
79MP0005501_abnormal_skin_physiology0.95079272
80MP0002084_abnormal_developmental_patter0.94084186
81MP0005408_hypopigmentation0.93924877
82MP0001293_anophthalmia0.93443248
83MP0002111_abnormal_tail_morphology0.92945934
84MP0002148_abnormal_hypersensitivity_rea0.92116096
85MP0004185_abnormal_adipocyte_glucose0.91976772
86MP0002877_abnormal_melanocyte_morpholog0.91838342
87MP0005000_abnormal_immune_tolerance0.91776677
88MP0003806_abnormal_nucleotide_metabolis0.91772939
89MP0002132_abnormal_respiratory_system0.91635777
90MP0010678_abnormal_skin_adnexa0.91374973
91MP0002938_white_spotting0.90684018
92MP0003705_abnormal_hypodermis_morpholog0.90057370
93MP0003315_abnormal_perineum_morphology0.89476188
94MP0006036_abnormal_mitochondrial_physio0.88936342
95MP0001145_abnormal_male_reproductive0.88894513
96MP0002160_abnormal_reproductive_system0.88734040
97MP0002009_preneoplasia0.88590579
98MP0003448_altered_tumor_morphology0.88174864
99MP0003718_maternal_effect0.87774775
100MP0008877_abnormal_DNA_methylation0.87281833
101MP0003436_decreased_susceptibility_to0.87117221
102MP0002095_abnormal_skin_pigmentation0.86764030
103MP0002102_abnormal_ear_morphology0.86017906
104MP0001929_abnormal_gametogenesis0.85430106
105MP0002233_abnormal_nose_morphology0.85273678
106MP0000537_abnormal_urethra_morphology0.84620412
107MP0000383_abnormal_hair_follicle0.83545776
108MP0003941_abnormal_skin_development0.83465623
109MP0010155_abnormal_intestine_physiology0.82422481
110MP0005025_abnormal_response_to0.82328431
111MP0000465_gastrointestinal_hemorrhage0.80104486
112MP0000653_abnormal_sex_gland0.79338045
113MP0003221_abnormal_cardiomyocyte_apopto0.78864419
114MP0004147_increased_porphyrin_level0.78740493
115MP0005503_abnormal_tendon_morphology0.78592764
116MP0003943_abnormal_hepatobiliary_system0.78165698
117MP0003119_abnormal_digestive_system0.76441014
118MP0009053_abnormal_anal_canal0.74872443
119MP0005220_abnormal_exocrine_pancreas0.74745698
120MP0004782_abnormal_surfactant_physiolog0.73548744
121MP0001119_abnormal_female_reproductive0.72852780
122MP0001915_intracranial_hemorrhage0.72757095
123MP0005389_reproductive_system_phenotype0.71443335
124MP0002163_abnormal_gland_morphology0.71178595
125MP0001764_abnormal_homeostasis0.71137552
126MP0006072_abnormal_retinal_apoptosis0.71041270
127MP0002092_abnormal_eye_morphology0.70484211
128MP0005076_abnormal_cell_differentiation0.70429941
129MP0000428_abnormal_craniofacial_morphol0.67948467
130MP0000627_abnormal_mammary_gland0.67806820
131MP0002210_abnormal_sex_determination0.66994639
132MP0001881_abnormal_mammary_gland0.66771532
133MP0003935_abnormal_craniofacial_develop0.66508995
134MP0000358_abnormal_cell_content/0.65968047
135MP0002933_joint_inflammation0.65884885
136MP0002282_abnormal_trachea_morphology0.65758213
137MP0005387_immune_system_phenotype0.65061510
138MP0001790_abnormal_immune_system0.65061510
139MP0003566_abnormal_cell_adhesion0.64548961
140MP0000372_irregular_coat_pigmentation0.64055323
141MP0000762_abnormal_tongue_morphology0.64047671
142MP0000733_abnormal_muscle_development0.63665496
143MP0005384_cellular_phenotype0.62831603
144MP0003755_abnormal_palate_morphology0.59927712
145MP0001177_atelectasis0.58056000
146MP0003385_abnormal_body_wall0.57422992
147MP0003936_abnormal_reproductive_system0.55885472

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.22278403
2Abnormal number of erythroid precursors (HP:0012131)4.87103634
3Reticulocytopenia (HP:0001896)4.80612284
4Birth length less than 3rd percentile (HP:0003561)3.82781701
5Colon cancer (HP:0003003)3.70379764
6Thrombocytosis (HP:0001894)3.58394209
7Aplastic anemia (HP:0001915)3.46047975
8Nephroblastoma (Wilms tumor) (HP:0002667)3.37187306
9Embryonal renal neoplasm (HP:0011794)3.21491987
1011 pairs of ribs (HP:0000878)3.20407189
11Pallor (HP:0000980)3.13821738
12Abnormality of methionine metabolism (HP:0010901)3.11661500
13Macrocytic anemia (HP:0001972)3.05842737
14Abnormality of the anterior horn cell (HP:0006802)2.99856541
15Degeneration of anterior horn cells (HP:0002398)2.99856541
16Increased hepatocellular lipid droplets (HP:0006565)2.97506532
17Microvesicular hepatic steatosis (HP:0001414)2.75850374
18Rhabdomyosarcoma (HP:0002859)2.69546901
19Selective tooth agenesis (HP:0001592)2.67093974
20Oral leukoplakia (HP:0002745)2.66901025
21Myelodysplasia (HP:0002863)2.56305027
22IgM deficiency (HP:0002850)2.53376647
23Breast hypoplasia (HP:0003187)2.49244505
24Lipid accumulation in hepatocytes (HP:0006561)2.43836958
25Triphalangeal thumb (HP:0001199)2.42704765
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42398839
27Megaloblastic anemia (HP:0001889)2.38523102
28Abnormality of chromosome stability (HP:0003220)2.34794795
29Abnormality of the labia minora (HP:0012880)2.31812963
30Acute lymphatic leukemia (HP:0006721)2.29049067
31Medulloblastoma (HP:0002885)2.28187075
32Absent thumb (HP:0009777)2.27527298
33Abnormality of the duodenum (HP:0002246)2.24901294
34Agnosia (HP:0010524)2.23955606
35Chromsome breakage (HP:0040012)2.23296171
36Rough bone trabeculation (HP:0100670)2.22923078
37Amaurosis fugax (HP:0100576)2.21874857
38Lymphoma (HP:0002665)2.21696465
39Glossoptosis (HP:0000162)2.21505052
40Abnormality of the calcaneus (HP:0008364)2.20218465
41Trismus (HP:0000211)2.19276443
42Pancreatic islet-cell hyperplasia (HP:0004510)2.18513397
43Patellar aplasia (HP:0006443)2.15195490
44Reduced antithrombin III activity (HP:0001976)2.13874300
45Multiple enchondromatosis (HP:0005701)2.13854274
46Basal cell carcinoma (HP:0002671)2.12768091
47Abnormality of glycolysis (HP:0004366)2.12472384
48Premature graying of hair (HP:0002216)2.11509069
49Cutaneous melanoma (HP:0012056)2.10920752
50Meckel diverticulum (HP:0002245)2.10006771
51Increased serum pyruvate (HP:0003542)2.09178667
52Abnormality of the preputium (HP:0100587)2.09081170
53Carpal bone hypoplasia (HP:0001498)2.04455845
54Increased nuchal translucency (HP:0010880)2.04452327
55Muscle fiber atrophy (HP:0100295)2.04008332
56Neoplasm of the pancreas (HP:0002894)2.03988637
57Spinal cord lesions (HP:0100561)2.01817590
58Syringomyelia (HP:0003396)2.01817590
59Optic nerve coloboma (HP:0000588)2.01532296
60Abnormality of T cell number (HP:0011839)2.01263475
61IgG deficiency (HP:0004315)2.01157152
62Abnormality of serum amino acid levels (HP:0003112)2.01062600
63Biliary tract neoplasm (HP:0100574)2.00957324
64Dyschromatopsia (HP:0007641)2.00087192
65T lymphocytopenia (HP:0005403)1.99434216
66Aplasia/Hypoplasia of the patella (HP:0006498)1.99343791
67Breast carcinoma (HP:0003002)1.98010930
68Irregular epiphyses (HP:0010582)1.97716649
69Ependymoma (HP:0002888)1.96804484
70Abnormality of the ileum (HP:0001549)1.96693503
71Abnormality of T cells (HP:0002843)1.95958874
72Abnormality of homocysteine metabolism (HP:0010919)1.95915795
73Homocystinuria (HP:0002156)1.95915795
74Ovarian neoplasm (HP:0100615)1.95846391
75Type 2 muscle fiber atrophy (HP:0003554)1.95647756
76Microretrognathia (HP:0000308)1.94864737
77Abnormal lung lobation (HP:0002101)1.92937805
78Atresia of the external auditory canal (HP:0000413)1.92349364
79Central scotoma (HP:0000603)1.90918654
80Abnormality of DNA repair (HP:0003254)1.90454034
81Calcaneovalgus deformity (HP:0001848)1.89264558
82Microglossia (HP:0000171)1.88543105
83Small intestinal stenosis (HP:0012848)1.87754883
84Duodenal stenosis (HP:0100867)1.87754883
85Neoplasm of the colon (HP:0100273)1.87589174
86Squamous cell carcinoma (HP:0002860)1.87324208
87Congenital, generalized hypertrichosis (HP:0004540)1.87063273
88Acute myeloid leukemia (HP:0004808)1.86885169
89Entropion (HP:0000621)1.86295106
90Bone marrow hypocellularity (HP:0005528)1.85597447
91B lymphocytopenia (HP:0010976)1.85419851
92Abnormality of B cell number (HP:0010975)1.85419851
93Recurrent bronchitis (HP:0002837)1.84368722
94Missing ribs (HP:0000921)1.83316217
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83111845
96Deviation of the thumb (HP:0009603)1.82603569
97Neoplasm of the small intestine (HP:0100833)1.81617918
98Hypoplastic pelvis (HP:0008839)1.81564536
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79985674
100Progressive external ophthalmoplegia (HP:0000590)1.79461421
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.79381246
102Methylmalonic acidemia (HP:0002912)1.79264708
103Posterior subcapsular cataract (HP:0007787)1.78685221
104Choanal atresia (HP:0000453)1.78649313
105Respiratory difficulties (HP:0002880)1.78225045
106Uterine neoplasm (HP:0010784)1.77652648
107Deep philtrum (HP:0002002)1.77194774
108Poor head control (HP:0002421)1.76779676
109Type I transferrin isoform profile (HP:0003642)1.76421989
110Proximal placement of thumb (HP:0009623)1.76277405
111Cafe-au-lait spot (HP:0000957)1.76054198
112Embryonal neoplasm (HP:0002898)1.75771524
113Abnormality of T cell physiology (HP:0011840)1.75733940
114Abnormal number of incisors (HP:0011064)1.75669550
115Bifid tongue (HP:0010297)1.75262560
116Horseshoe kidney (HP:0000085)1.75252250
117Poikiloderma (HP:0001029)1.74944234
118Gonadotropin excess (HP:0000837)1.74871207
119Stenosis of the external auditory canal (HP:0000402)1.74099581
120Cellular immunodeficiency (HP:0005374)1.73933552
121Increased density of long bones (HP:0006392)1.73927782
122Neoplasm of the adrenal cortex (HP:0100641)1.73032703
123Clubbing of toes (HP:0100760)1.72326500
124Neoplasm of the adrenal gland (HP:0100631)1.71842097
125Volvulus (HP:0002580)1.71558905
126Deformed tarsal bones (HP:0008119)1.71390886
127Short middle phalanx of the 5th finger (HP:0004220)1.70893843
128Cystic hygroma (HP:0000476)1.70350672
129Papillary thyroid carcinoma (HP:0002895)1.69554363
130Sloping forehead (HP:0000340)1.69443583
131Petechiae (HP:0000967)1.69183722
132Elevated erythrocyte sedimentation rate (HP:0003565)1.68715346
133Postnatal microcephaly (HP:0005484)1.67539499
134Thyroid carcinoma (HP:0002890)1.66188025
135Arteriovenous malformation (HP:0100026)1.65945106
136Pancytopenia (HP:0001876)1.65842899
137Depressed nasal ridge (HP:0000457)1.65031825
138Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.64644030
139Glioma (HP:0009733)1.64502168
140Cleft eyelid (HP:0000625)1.63957973
141Acute encephalopathy (HP:0006846)1.63696341
142Hyperinsulinemic hypoglycemia (HP:0000825)1.63369309
143Abnormal trabecular bone morphology (HP:0100671)1.63155608
144Asymmetry of the thorax (HP:0001555)1.62811117
145Hypoglycemic seizures (HP:0002173)1.62586652
146Hyperglycinemia (HP:0002154)1.62260006
147Recurrent viral infections (HP:0004429)1.62232823
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.61897945
149Asplenia (HP:0001746)1.61840751
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.61777979
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.61105796
152Cervical subluxation (HP:0003308)1.60592525
153Slender long bone (HP:0003100)1.60493483
154Absent radius (HP:0003974)1.59800152
155Increased CSF lactate (HP:0002490)1.59667035
156Increased serum lactate (HP:0002151)1.59657611
157Facial hemangioma (HP:0000329)1.59501746
158Angiofibromas (HP:0010615)1.59023309
159Adenoma sebaceum (HP:0009720)1.59023309
160Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58974654
161Hypoglycemic coma (HP:0001325)1.58460409
162Curly hair (HP:0002212)1.58192697
163Abnormality of reticulocytes (HP:0004312)1.56244898
164Abnormality of cells of the lymphoid lineage (HP:0012140)1.55798374
165Combined immunodeficiency (HP:0005387)1.55163833
166Facial cleft (HP:0002006)1.54904996
167Protrusio acetabuli (HP:0003179)1.54666799
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.53726694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.52146169
2WEE13.49220434
3BUB13.25231689
4CDC73.02346546
5EIF2AK12.94121903
6NEK22.63369020
7NME22.61316964
8VRK22.61280217
9ACVR1B2.31371377
10SRPK12.28240058
11TAF12.26117720
12TGFBR12.23634777
13EIF2AK32.16328295
14BRSK22.13185309
15MKNK12.08219334
16PASK2.07336160
17TSSK61.97395680
18RPS6KB21.79098962
19VRK11.74886184
20RPS6KA41.74788160
21PLK41.69138411
22DYRK31.67693845
23TRIM281.65405787
24MAP4K11.63717212
25STK161.60924988
26AURKB1.54118631
27PLK31.52188431
28LATS11.44905151
29PLK11.42493525
30EEF2K1.40816247
31ATR1.39686243
32PIM21.38176716
33MST41.36887198
34LRRK21.35545067
35TTK1.31727239
36STK101.28354118
37TNIK1.23824195
38FLT31.23502152
39TXK1.19083468
40CDK71.18675968
41PKN21.18281050
42ZAK1.15960733
43SCYL21.14895159
44MKNK21.09426290
45CCNB11.09317954
46TEC1.08823013
47STK38L1.06313420
48ALK1.05150368
49PIM11.03739986
50MAP3K81.00656675
51CDK40.98693223
52JAK30.98442802
53TLK10.98085612
54MAP2K30.97985738
55NME10.96842613
56ERBB30.96151938
57FGFR10.95311693
58PAK40.93438978
59STK40.92216183
60BRSK10.91883531
61SMG10.89820896
62ZAP700.89813070
63EIF2AK20.89361695
64CDK80.86458940
65CDK190.85783006
66BTK0.85067651
67TESK10.82718256
68TESK20.82074399
69CHEK20.81713805
70MAP3K30.79903253
71CHEK10.79644046
72KDR0.79031594
73MAP3K140.78695313
74NEK90.77760028
75CDK60.76785846
76STK390.74503748
77NUAK10.73240335
78IKBKB0.71834118
79AURKA0.71606679
80TAOK20.71349230
81KIT0.70078695
82ILK0.69612480
83BCR0.67514074
84MAP3K120.66042473
85ATM0.65222398
86CSNK2A10.63805603
87STK30.63464584
88CSNK2A20.62095045
89PNCK0.60196115
90EPHA20.59549325
91CHUK0.59037424
92BMPR20.58206525
93IRAK40.56571788
94RPS6KA50.55961223
95CSF1R0.55953995
96PBK0.55530397
97NLK0.55123907
98MST1R0.51709376
99MELK0.50574196
100CDK20.49977508
101CDK90.49721351
102CDK30.49518434
103CSNK1E0.48472611
104STK240.47115048
105RPS6KB10.44542412
106LIMK10.43836353
107FGFR20.43372876
108AKT30.43095080
109SIK30.42902355
110ITK0.42873275
111MAP3K100.42626297
112MAPKAPK30.39392532
113BMPR1B0.38153933
114TYK20.38028898
115TRPM70.37679322
116CLK10.37178645
117LYN0.35883954
118YES10.35362834
119PDK20.35335373
120TBK10.35271077
121MAPKAPK20.34704182
122BRD40.34601731
123CDK120.34354462
124SYK0.34161834
125CDK10.33615589
126LCK0.33072351
127MAPKAPK50.30918964
128NEK60.30546351
129PAK20.30261666
130PRKDC0.29966968
131WNK30.29691819
132ERBB40.29601750
133MET0.28355454
134MAP4K20.25511855
135BRAF0.25488155

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.35251092
2DNA replication_Homo sapiens_hsa030304.32077879
3Mismatch repair_Homo sapiens_hsa034303.64880357
4Proteasome_Homo sapiens_hsa030503.59083115
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21691122
6Spliceosome_Homo sapiens_hsa030403.07913470
7RNA polymerase_Homo sapiens_hsa030202.87884397
8* RNA transport_Homo sapiens_hsa030132.76058137
9Base excision repair_Homo sapiens_hsa034102.64156298
10Nucleotide excision repair_Homo sapiens_hsa034202.60075830
11Homologous recombination_Homo sapiens_hsa034402.50010948
12Cell cycle_Homo sapiens_hsa041102.40915814
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24686553
14Pyrimidine metabolism_Homo sapiens_hsa002402.18861474
15Non-homologous end-joining_Homo sapiens_hsa034502.10484085
16One carbon pool by folate_Homo sapiens_hsa006702.03967359
17RNA degradation_Homo sapiens_hsa030181.92309917
18Propanoate metabolism_Homo sapiens_hsa006401.79736147
19Fanconi anemia pathway_Homo sapiens_hsa034601.70045124
20p53 signaling pathway_Homo sapiens_hsa041151.67632596
21Basal transcription factors_Homo sapiens_hsa030221.64210830
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51979406
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48038900
24Antigen processing and presentation_Homo sapiens_hsa046121.41446750
25mRNA surveillance pathway_Homo sapiens_hsa030151.39743133
26Protein export_Homo sapiens_hsa030601.39452232
27Pyruvate metabolism_Homo sapiens_hsa006201.39451244
28Epstein-Barr virus infection_Homo sapiens_hsa051691.32226156
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27767460
30Primary immunodeficiency_Homo sapiens_hsa053401.21073158
31Herpes simplex infection_Homo sapiens_hsa051681.20763641
32Systemic lupus erythematosus_Homo sapiens_hsa053221.19418378
33Purine metabolism_Homo sapiens_hsa002301.17754382
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17676868
35Carbon metabolism_Homo sapiens_hsa012001.17434166
36Legionellosis_Homo sapiens_hsa051341.14282634
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09819704
38Allograft rejection_Homo sapiens_hsa053301.03827357
39Viral carcinogenesis_Homo sapiens_hsa052031.03674077
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01013350
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98411354
42Measles_Homo sapiens_hsa051620.96629034
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.91192759
44Oxidative phosphorylation_Homo sapiens_hsa001900.91114790
45Graft-versus-host disease_Homo sapiens_hsa053320.87574882
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85857430
47HTLV-I infection_Homo sapiens_hsa051660.84167657
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.83772033
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81480143
50Fatty acid elongation_Homo sapiens_hsa000620.80589334
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77246133
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75990380
53Hematopoietic cell lineage_Homo sapiens_hsa046400.74230844
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72764479
55Small cell lung cancer_Homo sapiens_hsa052220.72764105
56Selenocompound metabolism_Homo sapiens_hsa004500.69930511
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68021689
58Leishmaniasis_Homo sapiens_hsa051400.67960736
59Steroid biosynthesis_Homo sapiens_hsa001000.64999676
60Thyroid cancer_Homo sapiens_hsa052160.63742025
61Apoptosis_Homo sapiens_hsa042100.63395314
62Shigellosis_Homo sapiens_hsa051310.62546079
63Vitamin B6 metabolism_Homo sapiens_hsa007500.62106510
64Hepatitis B_Homo sapiens_hsa051610.58758648
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58077481
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57123927
67MicroRNAs in cancer_Homo sapiens_hsa052060.56842257
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56196585
69Viral myocarditis_Homo sapiens_hsa054160.54532961
70Pentose phosphate pathway_Homo sapiens_hsa000300.53609115
71Influenza A_Homo sapiens_hsa051640.52529498
72TGF-beta signaling pathway_Homo sapiens_hsa043500.51343848
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50939182
74Asthma_Homo sapiens_hsa053100.50664339
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49811662
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48987341
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.48976526
78Basal cell carcinoma_Homo sapiens_hsa052170.48783654
79N-Glycan biosynthesis_Homo sapiens_hsa005100.48555615
80Oocyte meiosis_Homo sapiens_hsa041140.48414859
81Folate biosynthesis_Homo sapiens_hsa007900.47864622
82Type I diabetes mellitus_Homo sapiens_hsa049400.46450356
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.46082246
84Autoimmune thyroid disease_Homo sapiens_hsa053200.45535449
85Butanoate metabolism_Homo sapiens_hsa006500.43136110
86Metabolic pathways_Homo sapiens_hsa011000.43006510
87Wnt signaling pathway_Homo sapiens_hsa043100.42299012
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.42221088
89Malaria_Homo sapiens_hsa051440.41807462
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41686151
91Colorectal cancer_Homo sapiens_hsa052100.41303080
92Vitamin digestion and absorption_Homo sapiens_hsa049770.41210235
93Hedgehog signaling pathway_Homo sapiens_hsa043400.40973127
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40072912
95Glutathione metabolism_Homo sapiens_hsa004800.39234647
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39215949
97Toxoplasmosis_Homo sapiens_hsa051450.38913591
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.38508906
99Alzheimers disease_Homo sapiens_hsa050100.38094952
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37887711
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37520820
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.35652575
103HIF-1 signaling pathway_Homo sapiens_hsa040660.35529402
104T cell receptor signaling pathway_Homo sapiens_hsa046600.34619263
105Lysine degradation_Homo sapiens_hsa003100.34086015
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33798932
107Chronic myeloid leukemia_Homo sapiens_hsa052200.33329667
108Huntingtons disease_Homo sapiens_hsa050160.33282617
109Fatty acid metabolism_Homo sapiens_hsa012120.32845247
110Biosynthesis of amino acids_Homo sapiens_hsa012300.32473635
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32453037
112Sulfur metabolism_Homo sapiens_hsa009200.30604213
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30517878
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29853302
115TNF signaling pathway_Homo sapiens_hsa046680.29607440
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.28230185
117Pathways in cancer_Homo sapiens_hsa052000.27481275
118Alcoholism_Homo sapiens_hsa050340.25870428
119Parkinsons disease_Homo sapiens_hsa050120.25859622
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25544601
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24193072
122B cell receptor signaling pathway_Homo sapiens_hsa046620.24123051
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23686339
124Adherens junction_Homo sapiens_hsa045200.23467191
125Hippo signaling pathway_Homo sapiens_hsa043900.23327213
126Prostate cancer_Homo sapiens_hsa052150.22516815
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21686303
128Acute myeloid leukemia_Homo sapiens_hsa052210.20852258
129Pertussis_Homo sapiens_hsa051330.20397289
130Fatty acid degradation_Homo sapiens_hsa000710.20001341
131Renin-angiotensin system_Homo sapiens_hsa046140.19959931
132Arachidonic acid metabolism_Homo sapiens_hsa005900.19664695
133Peroxisome_Homo sapiens_hsa041460.19170156
134Pancreatic cancer_Homo sapiens_hsa052120.11572192
135Arginine and proline metabolism_Homo sapiens_hsa003300.09343932
136Tight junction_Homo sapiens_hsa045300.07666656
137Melanoma_Homo sapiens_hsa052180.06853386
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04905844
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03889181
140mTOR signaling pathway_Homo sapiens_hsa041500.03223741
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01372167

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