EIF3FP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.06512915
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99634813
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.60794330
4ATP synthesis coupled proton transport (GO:0015986)5.60794330
5viral transcription (GO:0019083)5.53213518
6translational termination (GO:0006415)5.49768628
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.90957307
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.86888256
9ribosomal large subunit biogenesis (GO:0042273)4.86204544
10cotranslational protein targeting to membrane (GO:0006613)4.85083103
11protein targeting to ER (GO:0045047)4.74409806
12translational elongation (GO:0006414)4.71938971
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57369967
14protein localization to endoplasmic reticulum (GO:0070972)4.49606693
15translational initiation (GO:0006413)4.36046410
16DNA deamination (GO:0045006)4.34262475
17respiratory electron transport chain (GO:0022904)4.32041542
18cellular protein complex disassembly (GO:0043624)4.27738481
19electron transport chain (GO:0022900)4.23545594
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18237185
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.18237185
22NADH dehydrogenase complex assembly (GO:0010257)4.18237185
23regulation of mitochondrial translation (GO:0070129)4.08569894
24maturation of SSU-rRNA (GO:0030490)4.03834371
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02543283
26viral life cycle (GO:0019058)4.02363378
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.97801934
28ribosomal small subunit biogenesis (GO:0042274)3.83032370
29protein complex biogenesis (GO:0070271)3.81747099
30regulation of penile erection (GO:0060405)3.80168850
31oxidative phosphorylation (GO:0006119)3.77326614
32positive regulation of prostaglandin secretion (GO:0032308)3.66740084
33translation (GO:0006412)3.62853905
34protein complex disassembly (GO:0043241)3.60755127
35rRNA modification (GO:0000154)3.57358641
36mitochondrial respiratory chain complex assembly (GO:0033108)3.46611063
37macromolecular complex disassembly (GO:0032984)3.45001271
38rRNA methylation (GO:0031167)3.38800858
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.37487133
40seminiferous tubule development (GO:0072520)3.36142405
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30126724
42purine nucleotide salvage (GO:0032261)3.27109059
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.26841253
44purine nucleobase biosynthetic process (GO:0009113)3.21193125
45CENP-A containing nucleosome assembly (GO:0034080)3.19773198
46cellular component biogenesis (GO:0044085)3.15887636
47chromatin remodeling at centromere (GO:0031055)3.15067141
48formation of translation preinitiation complex (GO:0001731)3.12041328
49ribonucleoprotein complex biogenesis (GO:0022613)3.10146556
50protein K6-linked ubiquitination (GO:0085020)3.09650073
51chaperone-mediated protein transport (GO:0072321)3.08681973
52mRNA catabolic process (GO:0006402)3.06168504
53protein targeting to mitochondrion (GO:0006626)3.04034833
54nucleobase biosynthetic process (GO:0046112)3.03153731
55peptidyl-histidine modification (GO:0018202)3.01611097
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01489829
57ATP biosynthetic process (GO:0006754)3.00688955
58sequestering of actin monomers (GO:0042989)3.00397585
59mismatch repair (GO:0006298)2.99745018
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98450771
61protein targeting to membrane (GO:0006612)2.97174918
62regulation of cellular amino acid metabolic process (GO:0006521)2.96209417
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95734271
64negative regulation of ligase activity (GO:0051352)2.94048944
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94048944
66spliceosomal snRNP assembly (GO:0000387)2.92867603
67negative regulation of B cell apoptotic process (GO:0002903)2.92691011
68purine-containing compound salvage (GO:0043101)2.91675782
69maturation of 5.8S rRNA (GO:0000460)2.90389383
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86827954
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84959740
72positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83755610
73negative regulation by host of viral transcription (GO:0043922)2.83108219
74purine deoxyribonucleotide catabolic process (GO:0009155)2.82105881
75RNA catabolic process (GO:0006401)2.81983673
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81820951
77regulation of prostaglandin secretion (GO:0032306)2.80766339
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80482829
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80482829
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80482829
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80336762
82proteasome assembly (GO:0043248)2.79539432
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78642069
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78642069
85meiosis I (GO:0007127)2.77394037
86sleep (GO:0030431)2.77076059
87establishment of protein localization to mitochondrion (GO:0072655)2.76514458
88rRNA processing (GO:0006364)2.76167811
89rRNA metabolic process (GO:0016072)2.75438681
90male meiosis I (GO:0007141)2.74396154
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74366470
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74366470
93inner mitochondrial membrane organization (GO:0007007)2.72822426
94histone exchange (GO:0043486)2.72084642
95adenosine metabolic process (GO:0046085)2.70488753
96grooming behavior (GO:0007625)2.69252816
97nucleoside transmembrane transport (GO:1901642)2.68439975
98signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66912361
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.66912361
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66505553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84703564
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.32250395
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.15613337
4E2F7_22180533_ChIP-Seq_HELA_Human4.01341074
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.38622973
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35218697
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31269320
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.26365280
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25043531
10ELK1_19687146_ChIP-ChIP_HELA_Human3.18705926
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06984182
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94603855
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87861743
14VDR_23849224_ChIP-Seq_CD4+_Human2.80152684
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73592638
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56955556
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51235666
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48299269
19FOXP3_21729870_ChIP-Seq_TREG_Human2.44502780
20VDR_22108803_ChIP-Seq_LS180_Human2.44250159
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41311681
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.34501817
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30396130
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.16838711
25MYC_18940864_ChIP-ChIP_HL60_Human2.16217359
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13959785
27TTF2_22483619_ChIP-Seq_HELA_Human2.11284894
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05139528
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02998263
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99206405
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95005798
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91583472
33XRN2_22483619_ChIP-Seq_HELA_Human1.90925438
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83375986
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80730002
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70647955
37GABP_19822575_ChIP-Seq_HepG2_Human1.65159658
38FUS_26573619_Chip-Seq_HEK293_Human1.62099824
39EWS_26573619_Chip-Seq_HEK293_Human1.60723592
40DCP1A_22483619_ChIP-Seq_HELA_Human1.60392820
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.58379983
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57330077
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.56708700
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55738132
45ZNF274_21170338_ChIP-Seq_K562_Hela1.46316522
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45291308
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45103433
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44721069
49TP53_22573176_ChIP-Seq_HFKS_Human1.43995935
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41685514
51IRF1_19129219_ChIP-ChIP_H3396_Human1.41164158
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39806245
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34733029
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31890796
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31204844
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29371022
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27932058
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.26696285
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26519752
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.25906393
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.21075419
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21064880
63IGF1R_20145208_ChIP-Seq_DFB_Human1.19394576
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18159903
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13114438
66CIITA_25753668_ChIP-Seq_RAJI_Human1.12972046
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12798589
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.09452315
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03188138
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01989131
71NOTCH1_21737748_ChIP-Seq_TLL_Human0.97975883
72KDM5A_27292631_Chip-Seq_BREAST_Human0.97838685
73ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97234414
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94066800
75ELF5_23300383_ChIP-Seq_T47D_Human0.93444287
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92195979
77AR_21909140_ChIP-Seq_LNCAP_Human0.91573632
78POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90951504
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90470674
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.88485024
81SOX2_19829295_ChIP-Seq_ESCs_Human0.88087157
82NANOG_19829295_ChIP-Seq_ESCs_Human0.88087157
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87641646
84NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86533804
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86331664
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.85844204
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85166307
88AR_20517297_ChIP-Seq_VCAP_Human0.84153293
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83491554
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83275408
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82044255
92CBP_20019798_ChIP-Seq_JUKART_Human0.80448557
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80448557
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79336404
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78780270
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.78285946
97P300_19829295_ChIP-Seq_ESCs_Human0.77764583
98ERG_20517297_ChIP-Seq_VCAP_Human0.77085610
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.75451005
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75367039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.41933496
2MP0000372_irregular_coat_pigmentation4.36536027
3MP0008058_abnormal_DNA_repair3.45388448
4MP0006292_abnormal_olfactory_placode3.34801976
5MP0009697_abnormal_copulation3.03996655
6MP0005075_abnormal_melanosome_morpholog2.83697736
7MP0003718_maternal_effect2.80903914
8MP0003806_abnormal_nucleotide_metabolis2.69881102
9MP0010094_abnormal_chromosome_stability2.54280778
10MP0002822_catalepsy2.43800184
11MP0003646_muscle_fatigue2.25451276
12MP0006072_abnormal_retinal_apoptosis2.11897674
13MP0003186_abnormal_redox_activity2.07918428
14MP0002102_abnormal_ear_morphology2.06096846
15MP0003786_premature_aging1.95807458
16MP0003136_yellow_coat_color1.94803532
17MP0005646_abnormal_pituitary_gland1.87869829
18MP0005645_abnormal_hypothalamus_physiol1.78775820
19MP0005410_abnormal_fertilization1.78186717
20MP0004957_abnormal_blastocyst_morpholog1.78037330
21MP0002938_white_spotting1.71042017
22MP0005408_hypopigmentation1.67366205
23MP0002928_abnormal_bile_duct1.64095754
24MP0002095_abnormal_skin_pigmentation1.63299633
25MP0002160_abnormal_reproductive_system1.53447464
26MP0003693_abnormal_embryo_hatching1.53069660
27MP0001984_abnormal_olfaction1.50542994
28MP0002837_dystrophic_cardiac_calcinosis1.49224559
29MP0005083_abnormal_biliary_tract1.47622650
30MP0001764_abnormal_homeostasis1.47510395
31MP0005253_abnormal_eye_physiology1.42151443
32MP0003880_abnormal_central_pattern1.41194908
33MP0003077_abnormal_cell_cycle1.40057525
34MP0001293_anophthalmia1.38230612
35MP0005174_abnormal_tail_pigmentation1.32267490
36MP0005084_abnormal_gallbladder_morpholo1.28813871
37MP0005171_absent_coat_pigmentation1.26705575
38MP0008877_abnormal_DNA_methylation1.26061235
39MP0006054_spinal_hemorrhage1.24387727
40MP0004133_heterotaxia1.23627407
41MP0001835_abnormal_antigen_presentation1.21979602
42MP0003252_abnormal_bile_duct1.21071589
43MP0003111_abnormal_nucleus_morphology1.19582822
44MP0000465_gastrointestinal_hemorrhage1.19223707
45MP0005551_abnormal_eye_electrophysiolog1.19025559
46MP0005389_reproductive_system_phenotype1.14522806
47MP0005085_abnormal_gallbladder_physiolo1.14395125
48MP0002736_abnormal_nociception_after1.13589993
49MP0001929_abnormal_gametogenesis1.12047706
50MP0002090_abnormal_vision1.06884176
51MP0002148_abnormal_hypersensitivity_rea1.06052931
52MP0004142_abnormal_muscle_tone1.05311294
53MP0005377_hearing/vestibular/ear_phenot1.03512120
54MP0003878_abnormal_ear_physiology1.03512120
55MP0006036_abnormal_mitochondrial_physio1.03004915
56MP0005671_abnormal_response_to1.02958624
57MP0002234_abnormal_pharynx_morphology1.02890519
58MP0005395_other_phenotype1.02268086
59MP0000613_abnormal_salivary_gland1.01034900
60MP0002006_tumorigenesis0.99473666
61MP0002210_abnormal_sex_determination0.98934975
62MP0002019_abnormal_tumor_incidence0.94845578
63MP0001881_abnormal_mammary_gland0.94173660
64MP0004145_abnormal_muscle_electrophysio0.93602738
65MP0006276_abnormal_autonomic_nervous0.92648112
66MP0010368_abnormal_lymphatic_system0.91217787
67MP0010386_abnormal_urinary_bladder0.90844455
68MP0006035_abnormal_mitochondrial_morpho0.90740565
69MP0002653_abnormal_ependyma_morphology0.90656567
70MP0004134_abnormal_chest_morphology0.89419960
71MP0010030_abnormal_orbit_morphology0.88399024
72MP0001119_abnormal_female_reproductive0.88212398
73MP0000631_abnormal_neuroendocrine_gland0.87560399
74MP0005319_abnormal_enzyme/_coenzyme0.86600955
75MP0004147_increased_porphyrin_level0.84386874
76MP0008875_abnormal_xenobiotic_pharmacok0.82855242
77MP0008932_abnormal_embryonic_tissue0.82570732
78MP0000653_abnormal_sex_gland0.81573313
79MP0008007_abnormal_cellular_replicative0.80646846
80MP0004808_abnormal_hematopoietic_stem0.79601012
81MP0002277_abnormal_respiratory_mucosa0.79437590
82MP0002751_abnormal_autonomic_nervous0.79102528
83MP0001501_abnormal_sleep_pattern0.78762723
84MP0005391_vision/eye_phenotype0.77324115
85MP0009278_abnormal_bone_marrow0.76401777
86MP0001145_abnormal_male_reproductive0.74036021
87MP0008995_early_reproductive_senescence0.72932513
88MP0003567_abnormal_fetal_cardiomyocyte0.72901796
89MP0000516_abnormal_urinary_system0.72406432
90MP0005367_renal/urinary_system_phenotyp0.72406432
91MP0003698_abnormal_male_reproductive0.72256158
92MP0008872_abnormal_physiological_respon0.71672320
93MP0003763_abnormal_thymus_physiology0.69656626
94MP0001879_abnormal_lymphatic_vessel0.69626601
95MP0000627_abnormal_mammary_gland0.68622034
96MP0009765_abnormal_xenobiotic_induced0.67066280
97MP0002398_abnormal_bone_marrow0.66633329
98MP0000689_abnormal_spleen_morphology0.65612815
99MP0001968_abnormal_touch/_nociception0.62857425
100MP0000538_abnormal_urinary_bladder0.62726412

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.69985972
2Mitochondrial inheritance (HP:0001427)4.58885603
3Acute necrotizing encephalopathy (HP:0006965)4.49698823
4Hepatocellular necrosis (HP:0001404)4.41138992
5Lipid accumulation in hepatocytes (HP:0006561)4.35974551
6Abnormal mitochondria in muscle tissue (HP:0008316)4.34442676
7Increased CSF lactate (HP:0002490)4.25161219
8Increased hepatocellular lipid droplets (HP:0006565)4.23450338
9Acute encephalopathy (HP:0006846)3.99110548
10Reticulocytopenia (HP:0001896)3.97720498
11Progressive macrocephaly (HP:0004481)3.82713777
12Cerebral edema (HP:0002181)3.72950183
13Hepatic necrosis (HP:0002605)3.71926845
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65431579
15Renal Fanconi syndrome (HP:0001994)3.25796533
16Abnormality of cells of the erythroid lineage (HP:0012130)3.06053051
17Abnormal number of erythroid precursors (HP:0012131)3.04000882
18Increased intramyocellular lipid droplets (HP:0012240)3.03479131
19Exertional dyspnea (HP:0002875)2.93035906
20Type I transferrin isoform profile (HP:0003642)2.90727551
21Macrocytic anemia (HP:0001972)2.86654426
22Increased muscle lipid content (HP:0009058)2.85858547
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79202051
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78147115
25Oral leukoplakia (HP:0002745)2.71892211
26Respiratory failure (HP:0002878)2.70531421
27Hypochromic microcytic anemia (HP:0004840)2.63159043
28Pancreatic cysts (HP:0001737)2.62838900
29Lethargy (HP:0001254)2.61200939
30Medial flaring of the eyebrow (HP:0010747)2.59248317
31Degeneration of anterior horn cells (HP:0002398)2.58978367
32Abnormality of the anterior horn cell (HP:0006802)2.58978367
33Reduced antithrombin III activity (HP:0001976)2.54704486
34Hyperglycinemia (HP:0002154)2.52914755
35Increased serum lactate (HP:0002151)2.52853390
36Pancytopenia (HP:0001876)2.51243479
37Lactic acidosis (HP:0003128)2.50670592
38Methylmalonic acidemia (HP:0002912)2.49531108
39Pallor (HP:0000980)2.44360980
40Exercise intolerance (HP:0003546)2.42386947
41Respiratory difficulties (HP:0002880)2.39444676
42Pancreatic fibrosis (HP:0100732)2.37676792
43Abnormal protein glycosylation (HP:0012346)2.33933265
44Abnormal glycosylation (HP:0012345)2.33933265
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33933265
46Abnormal protein N-linked glycosylation (HP:0012347)2.33933265
47Type II lissencephaly (HP:0007260)2.33302368
48Septo-optic dysplasia (HP:0100842)2.25896851
49Optic disc pallor (HP:0000543)2.23768411
50CNS demyelination (HP:0007305)2.21062491
51Congenital stationary night blindness (HP:0007642)2.16685944
52Congenital, generalized hypertrichosis (HP:0004540)2.15422433
53Abnormality of methionine metabolism (HP:0010901)2.13733725
54Absent thumb (HP:0009777)2.13163657
55Hyperglycinuria (HP:0003108)2.10153460
56Abnormal biliary tract physiology (HP:0012439)2.09958656
57Bile duct proliferation (HP:0001408)2.09958656
58Methylmalonic aciduria (HP:0012120)2.07775358
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06790737
603-Methylglutaconic aciduria (HP:0003535)2.06336500
61Elevated erythrocyte sedimentation rate (HP:0003565)2.06143365
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05889565
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05889565
64Type 2 muscle fiber atrophy (HP:0003554)2.04989910
65Progressive muscle weakness (HP:0003323)2.04959192
66Abnormality of the renal cortex (HP:0011035)2.03482985
67Cerebellar dysplasia (HP:0007033)2.02001289
68Severe combined immunodeficiency (HP:0004430)2.01266618
69Leukodystrophy (HP:0002415)1.98695523
70Abnormality of B cell number (HP:0010975)1.95655636
71Abnormality of serum amino acid levels (HP:0003112)1.90853550
72Homocystinuria (HP:0002156)1.90086352
73Abnormality of homocysteine metabolism (HP:0010919)1.90086352
74Attenuation of retinal blood vessels (HP:0007843)1.89446180
75Ketosis (HP:0001946)1.88826529
76IgM deficiency (HP:0002850)1.87686708
77Hypothermia (HP:0002045)1.86254105
78Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86043847
79Dicarboxylic aciduria (HP:0003215)1.86043847
80Congenital primary aphakia (HP:0007707)1.84414826
81Rib fusion (HP:0000902)1.81531365
82Chromsome breakage (HP:0040012)1.79742909
83Triphalangeal thumb (HP:0001199)1.78404144
84B lymphocytopenia (HP:0010976)1.77077053
85Hypoplasia of the pons (HP:0012110)1.75188298
86Emotional lability (HP:0000712)1.74719370
87Supernumerary spleens (HP:0009799)1.74243634
88Hypoalbuminemia (HP:0003073)1.73961394
89Abnormal albumin level (HP:0012116)1.73961394
90Abnormality of alanine metabolism (HP:0010916)1.72979543
91Hyperalaninemia (HP:0003348)1.72979543
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72979543
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.72046378
94Abnormal ciliary motility (HP:0012262)1.71562747
95Asplenia (HP:0001746)1.71199083
96Thrombocytosis (HP:0001894)1.70904053
97Abnormality of renal resorption (HP:0011038)1.70626242
98Tubular atrophy (HP:0000092)1.70172556
99Abnormality of the pons (HP:0007361)1.70060969
100Gait imbalance (HP:0002141)1.69706766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.43142060
2VRK23.68766777
3BCKDK3.66732343
4SCYL23.00616017
5MAP4K22.65486541
6TRIM282.58784468
7TAOK32.55720952
8EIF2AK12.47018126
9TXK2.41060648
10PDK22.37968648
11PBK2.34305938
12KDR2.27958797
13BUB12.15203424
14ZAK1.99778778
15BMPR1B1.96248484
16STK161.94718651
17MAP2K71.90033593
18FRK1.88588106
19CDC71.82344008
20MST41.67900394
21CCNB11.62889291
22SIK31.59344777
23ACVR1B1.52182016
24EIF2AK31.43989112
25BMPR21.41149585
26FLT31.36860734
27TAF11.36109489
28WEE11.33041627
29NUAK11.32472186
30VRK11.29370587
31NME21.17794366
32TEC1.13839007
33BCR1.11450287
34SRPK11.09632284
35OXSR11.06868400
36KIT1.02499441
37WNK30.99483241
38BRSK20.98184540
39PLK30.96580251
40FES0.94353901
41MAP4K10.91617344
42PASK0.88384296
43TNK20.85303010
44TLK10.84628431
45PLK40.83013755
46AURKB0.82432400
47GRK10.81078185
48ERBB30.79424437
49ZAP700.79120466
50TSSK60.78641287
51RPS6KA40.78419913
52ATR0.77528497
53PIM20.76990496
54PIK3CG0.74823479
55MKNK10.70613058
56TESK20.69557236
57TTK0.69283100
58RPS6KA50.68957354
59TNIK0.68742242
60ADRBK20.67286870
61PLK10.65787680
62GRK60.65200342
63CSNK2A20.63730973
64ILK0.63258106
65ITK0.61539902
66MAP3K40.61457587
67SYK0.59955533
68AURKA0.58885818
69CHEK20.58684286
70INSRR0.54458526
71PINK10.53432255
72CDK30.52805852
73MST1R0.51374869
74ADRBK10.50982377
75CSNK2A10.50308534
76MATK0.48945038
77MELK0.46210048
78TGFBR10.46170209
79MUSK0.43674837
80CDK80.40205960
81BTK0.36986959
82PLK20.33820536
83CSNK1A10.32654122
84ERBB40.30455541
85CAMK10.29636559
86LCK0.29288067
87IKBKB0.29045647
88LYN0.27932787
89CHEK10.27899111
90IGF1R0.27277776
91PAK10.26938656
92NME10.26422451
93NEK20.25826593
94ATM0.25820208
95MAPK130.25737770
96STK40.25385985
97CSF1R0.24935316
98TBK10.23731563
99EIF2AK20.23397464
100CDK40.22241791

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.71416414
2Oxidative phosphorylation_Homo sapiens_hsa001904.11345089
3Proteasome_Homo sapiens_hsa030504.01987200
4Parkinsons disease_Homo sapiens_hsa050123.50224697
5Mismatch repair_Homo sapiens_hsa034302.59470284
6DNA replication_Homo sapiens_hsa030302.59324448
7RNA polymerase_Homo sapiens_hsa030202.56715609
8Huntingtons disease_Homo sapiens_hsa050162.45358928
9Non-homologous end-joining_Homo sapiens_hsa034502.44808162
10Homologous recombination_Homo sapiens_hsa034402.44556035
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42698403
12Alzheimers disease_Homo sapiens_hsa050102.39987272
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23758336
14One carbon pool by folate_Homo sapiens_hsa006702.05798228
15Protein export_Homo sapiens_hsa030602.02633759
16Base excision repair_Homo sapiens_hsa034102.02507480
17Fanconi anemia pathway_Homo sapiens_hsa034601.80811303
18RNA transport_Homo sapiens_hsa030131.76536331
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68165876
20RNA degradation_Homo sapiens_hsa030181.63230042
21Basal transcription factors_Homo sapiens_hsa030221.63057474
22Nucleotide excision repair_Homo sapiens_hsa034201.60394088
23Spliceosome_Homo sapiens_hsa030401.51834821
24Pyrimidine metabolism_Homo sapiens_hsa002401.50187211
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45035425
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38532323
27Phototransduction_Homo sapiens_hsa047441.35949762
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31416241
29Cardiac muscle contraction_Homo sapiens_hsa042601.28415412
30Asthma_Homo sapiens_hsa053101.25900060
31Allograft rejection_Homo sapiens_hsa053301.21382847
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20747393
33Autoimmune thyroid disease_Homo sapiens_hsa053201.19934783
34Purine metabolism_Homo sapiens_hsa002301.18706222
35Type I diabetes mellitus_Homo sapiens_hsa049401.16386488
36Peroxisome_Homo sapiens_hsa041461.15798383
37Graft-versus-host disease_Homo sapiens_hsa053321.14383623
38Primary immunodeficiency_Homo sapiens_hsa053401.13477071
39Systemic lupus erythematosus_Homo sapiens_hsa053221.05087613
40Propanoate metabolism_Homo sapiens_hsa006401.01558421
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00094316
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.98589202
43Folate biosynthesis_Homo sapiens_hsa007900.98283267
44Glutathione metabolism_Homo sapiens_hsa004800.97015018
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.82269219
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.80635480
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79945064
48p53 signaling pathway_Homo sapiens_hsa041150.77970989
49Nitrogen metabolism_Homo sapiens_hsa009100.76070666
50Hematopoietic cell lineage_Homo sapiens_hsa046400.74916485
51Antigen processing and presentation_Homo sapiens_hsa046120.72215380
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69859897
53Metabolic pathways_Homo sapiens_hsa011000.68993964
54Sulfur metabolism_Homo sapiens_hsa009200.68855830
55Pyruvate metabolism_Homo sapiens_hsa006200.67893846
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65610801
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64076973
58Rheumatoid arthritis_Homo sapiens_hsa053230.63705872
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63513279
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62166609
61Chemical carcinogenesis_Homo sapiens_hsa052040.61165260
62Cell cycle_Homo sapiens_hsa041100.60116725
63Caffeine metabolism_Homo sapiens_hsa002320.56936247
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55786385
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.53719645
66Herpes simplex infection_Homo sapiens_hsa051680.53312895
67Linoleic acid metabolism_Homo sapiens_hsa005910.53174537
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53045568
69Regulation of autophagy_Homo sapiens_hsa041400.51362824
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51228568
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51098569
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50576324
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47736766
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46770012
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46769809
76Epstein-Barr virus infection_Homo sapiens_hsa051690.46441279
77Retinol metabolism_Homo sapiens_hsa008300.44774102
78Viral myocarditis_Homo sapiens_hsa054160.42400190
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.41857993
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41325849
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39519315
82mRNA surveillance pathway_Homo sapiens_hsa030150.38758283
83Oocyte meiosis_Homo sapiens_hsa041140.38679877
84Olfactory transduction_Homo sapiens_hsa047400.37599302
85Fatty acid elongation_Homo sapiens_hsa000620.37445942
86Selenocompound metabolism_Homo sapiens_hsa004500.34818880
87Butanoate metabolism_Homo sapiens_hsa006500.34291164
88Tyrosine metabolism_Homo sapiens_hsa003500.34069981
89Fatty acid metabolism_Homo sapiens_hsa012120.33743148
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33718555
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31986401
92Tryptophan metabolism_Homo sapiens_hsa003800.31550444
93Fatty acid degradation_Homo sapiens_hsa000710.29790561
94Shigellosis_Homo sapiens_hsa051310.25392912
95Alcoholism_Homo sapiens_hsa050340.24227449
96ABC transporters_Homo sapiens_hsa020100.23333733
97N-Glycan biosynthesis_Homo sapiens_hsa005100.23218057
98Biosynthesis of amino acids_Homo sapiens_hsa012300.21432760
99beta-Alanine metabolism_Homo sapiens_hsa004100.19768196
100Carbon metabolism_Homo sapiens_hsa012000.16898006

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