EIF3FP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.91649309
2positive regulation of alpha-beta T cell proliferation (GO:0046641)4.30652035
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.04137206
4positive regulation of gamma-delta T cell activation (GO:0046645)4.00608941
5cellular response to interleukin-15 (GO:0071350)3.93075038
6cytidine deamination (GO:0009972)3.87446507
7cytidine metabolic process (GO:0046087)3.87446507
8cytidine catabolic process (GO:0006216)3.87446507
9negative T cell selection (GO:0043383)3.84149343
10regulation of alpha-beta T cell proliferation (GO:0046640)3.81644414
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.77146995
12proteasome assembly (GO:0043248)3.63403088
13negative thymic T cell selection (GO:0045060)3.63142537
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60515185
15positive thymic T cell selection (GO:0045059)3.57498752
16actin nucleation (GO:0045010)3.56737933
17regulation of gamma-delta T cell differentiation (GO:0045586)3.52406595
18regulation of B cell receptor signaling pathway (GO:0050855)3.37693189
19mast cell activation (GO:0045576)3.37422303
20chaperone mediated protein folding requiring cofactor (GO:0051085)3.34760189
21immunoglobulin mediated immune response (GO:0016064)3.33273090
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29015249
23response to interleukin-15 (GO:0070672)3.28298160
24T cell costimulation (GO:0031295)3.22509730
25negative regulation of T cell apoptotic process (GO:0070233)3.22419205
26lymphocyte costimulation (GO:0031294)3.21875599
27antigen processing and presentation of endogenous antigen (GO:0019883)3.20810059
28pyrimidine ribonucleoside catabolic process (GO:0046133)3.20452474
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20397876
30T cell receptor signaling pathway (GO:0050852)3.16495799
31B cell mediated immunity (GO:0019724)3.16094091
32positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.15862344
33formation of translation preinitiation complex (GO:0001731)3.15763955
34regulation of gamma-delta T cell activation (GO:0046643)3.11513386
35positive regulation of B cell differentiation (GO:0045579)3.10321646
36regulation of regulatory T cell differentiation (GO:0045589)3.08664393
37positive T cell selection (GO:0043368)3.08352272
38positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07615782
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02745952
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02627768
41antigen receptor-mediated signaling pathway (GO:0050851)3.01821443
42interferon-gamma production (GO:0032609)3.01250431
43regulation of B cell differentiation (GO:0045577)2.95395541
44regulation of cellular amino acid metabolic process (GO:0006521)2.94059731
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.93174606
46ribosomal small subunit assembly (GO:0000028)2.93035370
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.92993809
48positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90300049
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90035166
50negative regulation of cell killing (GO:0031342)2.90035166
51positive regulation of natural killer cell mediated immunity (GO:0002717)2.89616318
52regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88434210
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86136531
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84256293
55mast cell degranulation (GO:0043303)2.83492142
56mast cell activation involved in immune response (GO:0002279)2.83492142
57positive regulation of T cell cytokine production (GO:0002726)2.83393541
58thymic T cell selection (GO:0045061)2.81067049
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.80050763
60positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.78185177
61positive regulation of interleukin-17 production (GO:0032740)2.77654768
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75828527
63regulation of natural killer cell mediated immunity (GO:0002715)2.75826012
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75826012
65neutrophil activation involved in immune response (GO:0002283)2.75690952
66autophagic vacuole fusion (GO:0000046)2.75642560
67regulation of chronic inflammatory response (GO:0002676)2.74874567
68positive regulation of lamellipodium assembly (GO:0010592)2.73863749
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73441000
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73441000
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73436681
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73436681
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73436681
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73290636
75regulation of isotype switching to IgG isotypes (GO:0048302)2.72387565
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71316797
77regulation of interleukin-2 biosynthetic process (GO:0045076)2.69580280
78positive regulation of defense response to virus by host (GO:0002230)2.68690802
79regulation of T cell mediated cytotoxicity (GO:0001914)2.67809658
80purine deoxyribonucleotide catabolic process (GO:0009155)2.67740092
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67445983
82leukocyte aggregation (GO:0070486)2.66786211
83positive regulation of interleukin-4 production (GO:0032753)2.63963948
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63605440
85response to interferon-beta (GO:0035456)2.62673019
86positive regulation of interleukin-8 secretion (GO:2000484)2.62433368
87regulation of T cell tolerance induction (GO:0002664)2.61662666
88positive regulation of interleukin-2 production (GO:0032743)2.61323764
89antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.61295686
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.60417132
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.60116547
92signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60116547
93T cell migration (GO:0072678)2.59729928
94regulation of T cell receptor signaling pathway (GO:0050856)2.59267587
95protein refolding (GO:0042026)2.59204138
96positive regulation of interferon-gamma production (GO:0032729)2.58002199
97positive regulation of cell killing (GO:0031343)2.57615663
98positive regulation of granulocyte differentiation (GO:0030854)2.54161633
99rRNA modification (GO:0000154)2.53742959
100signal transduction involved in cell cycle checkpoint (GO:0072395)2.53663891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.90214694
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.49801209
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.46280308
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.36698109
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.36422345
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25014350
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21183705
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11508277
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09883505
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92188278
11VDR_23849224_ChIP-Seq_CD4+_Human2.88784111
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85277801
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79179716
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.73951566
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71034582
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.61768047
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.57017345
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.51165291
19MYB_26560356_Chip-Seq_TH2_Human2.49651064
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35620124
21FOXP3_21729870_ChIP-Seq_TREG_Human2.30212332
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25690057
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14034253
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12165192
25RUNX_20019798_ChIP-Seq_JUKART_Human1.96152188
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.91900184
27CIITA_25753668_ChIP-Seq_RAJI_Human1.90866579
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87754683
29SPI1_23547873_ChIP-Seq_NB4_Human1.87513418
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84364746
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.82238850
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78566750
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78178630
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77278664
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72839113
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72668488
37MYB_26560356_Chip-Seq_TH1_Human1.66745055
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65717508
39GATA3_26560356_Chip-Seq_TH2_Human1.63958066
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62011281
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60950055
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60259578
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54972459
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50247345
45GATA3_27048872_Chip-Seq_THYMUS_Human1.49665031
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47581930
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46605786
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44654803
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43904122
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42371880
51ELK1_19687146_ChIP-ChIP_HELA_Human1.41074592
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35296575
53DCP1A_22483619_ChIP-Seq_HELA_Human1.34883411
54MAF_26560356_Chip-Seq_TH1_Human1.31822551
55UTX_26944678_Chip-Seq_JUKART_Human1.29319963
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23578729
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23160367
58BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22722421
59GABP_19822575_ChIP-Seq_HepG2_Human1.22271683
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.22022076
61MYC_18940864_ChIP-ChIP_HL60_Human1.20594945
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19259549
63FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19013901
64VDR_22108803_ChIP-Seq_LS180_Human1.18341213
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17807611
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17189120
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16842691
68MAF_26560356_Chip-Seq_TH2_Human1.15120050
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14398476
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13277605
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12828819
72TTF2_22483619_ChIP-Seq_HELA_Human1.12612395
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09668300
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08764545
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05996345
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03608750
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01241486
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00704727
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.00506165
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.00379331
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99710272
82MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99142229
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98504609
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97097860
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94029736
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93211553
87AR_20517297_ChIP-Seq_VCAP_Human0.92940212
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92216943
89GATA3_26560356_Chip-Seq_TH1_Human0.92001962
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91493969
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.90830098
92NANOG_20526341_ChIP-Seq_ESCs_Human0.90247171
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89060998
94TP53_22573176_ChIP-Seq_HFKS_Human0.88708971
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87821622
96BCL6_27268052_Chip-Seq_Bcells_Human0.86798749
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86715757
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86238188
99KDM5A_27292631_Chip-Seq_BREAST_Human0.86238043
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85030541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.43793063
2MP0001835_abnormal_antigen_presentation4.27662762
3MP0003763_abnormal_thymus_physiology3.40084433
4MP0003806_abnormal_nucleotide_metabolis2.93960876
5MP0005000_abnormal_immune_tolerance2.88315268
6MP0009333_abnormal_splenocyte_physiolog2.78546891
7MP0009785_altered_susceptibility_to2.73023302
8MP0002148_abnormal_hypersensitivity_rea2.67496122
9MP0001873_stomach_inflammation2.65259798
10MP0001800_abnormal_humoral_immune2.61619240
11MP0000685_abnormal_immune_system2.47748303
12MP0002723_abnormal_immune_serum2.42532668
13MP0005075_abnormal_melanosome_morpholog2.30817106
14MP0002420_abnormal_adaptive_immunity2.27472278
15MP0001819_abnormal_immune_cell2.24369147
16MP0008877_abnormal_DNA_methylation2.24306331
17MP0002452_abnormal_antigen_presenting2.18661299
18MP0003436_decreased_susceptibility_to2.12604380
19MP0002006_tumorigenesis2.11081253
20MP0002398_abnormal_bone_marrow2.10295169
21MP0005025_abnormal_response_to2.06531153
22MP0008058_abnormal_DNA_repair2.03787293
23MP0001790_abnormal_immune_system1.99441795
24MP0005387_immune_system_phenotype1.99441795
25MP0002166_altered_tumor_susceptibility1.97675551
26MP0002102_abnormal_ear_morphology1.94091877
27MP0000716_abnormal_immune_system1.89260276
28MP0000689_abnormal_spleen_morphology1.80128436
29MP0002138_abnormal_hepatobiliary_system1.77704598
30MP0000703_abnormal_thymus_morphology1.74517385
31MP0000372_irregular_coat_pigmentation1.74509070
32MP0002419_abnormal_innate_immunity1.74361770
33MP0005084_abnormal_gallbladder_morpholo1.73421166
34MP0003866_abnormal_defecation1.73401915
35MP0002722_abnormal_immune_system1.68652921
36MP0002396_abnormal_hematopoietic_system1.68091956
37MP0010155_abnormal_intestine_physiology1.60407102
38MP0002429_abnormal_blood_cell1.56736332
39MP0001845_abnormal_inflammatory_respons1.55788396
40MP0006072_abnormal_retinal_apoptosis1.53065436
41MP0002405_respiratory_system_inflammati1.50695449
42MP0000465_gastrointestinal_hemorrhage1.49240707
43MP0003786_premature_aging1.47991970
44MP0004145_abnormal_muscle_electrophysio1.44446896
45MP0001853_heart_inflammation1.43676202
46MP0005464_abnormal_platelet_physiology1.42415812
47MP0006036_abnormal_mitochondrial_physio1.41457827
48MP0005410_abnormal_fertilization1.41377735
49MP0008469_abnormal_protein_level1.37653394
50MP0009764_decreased_sensitivity_to1.30514744
51MP0004147_increased_porphyrin_level1.28263456
52MP0006082_CNS_inflammation1.27442524
53MP0003724_increased_susceptibility_to1.25696594
54MP0005310_abnormal_salivary_gland1.22995685
55MP0006292_abnormal_olfactory_placode1.17316463
56MP0002019_abnormal_tumor_incidence1.15809710
57MP0003646_muscle_fatigue1.14011455
58MP0002638_abnormal_pupillary_reflex1.07042426
59MP0001542_abnormal_bone_strength1.01003391
60MP0005645_abnormal_hypothalamus_physiol1.00833965
61MP0010094_abnormal_chromosome_stability0.98525556
62MP0008995_early_reproductive_senescence0.97630597
63MP0002928_abnormal_bile_duct0.96158757
64MP0005257_abnormal_intraocular_pressure0.95369480
65MP0008875_abnormal_xenobiotic_pharmacok0.95159770
66MP0008007_abnormal_cellular_replicative0.94290134
67MP0002933_joint_inflammation0.93507195
68MP0002693_abnormal_pancreas_physiology0.90058189
69MP0001764_abnormal_homeostasis0.89695089
70MP0004947_skin_inflammation0.88072247
71MP0003186_abnormal_redox_activity0.86526415
72MP0003075_altered_response_to0.85279777
73MP0001533_abnormal_skeleton_physiology0.85275071
74MP0003787_abnormal_imprinting0.84051527
75MP0002132_abnormal_respiratory_system0.82509905
76MP0009763_increased_sensitivity_to0.81468937
77MP0004808_abnormal_hematopoietic_stem0.78156674
78MP0000613_abnormal_salivary_gland0.72388512
79MP0003252_abnormal_bile_duct0.71625468
80MP0002277_abnormal_respiratory_mucosa0.71262468
81MP0001119_abnormal_female_reproductive0.71077499
82MP0001919_abnormal_reproductive_system0.70274980
83MP0003656_abnormal_erythrocyte_physiolo0.69848159
84MP0004381_abnormal_hair_follicle0.68555782
85MP0001243_abnormal_dermal_layer0.68148875
86MP0008004_abnormal_stomach_pH0.68036986
87MP0003045_fibrosis0.64657636
88MP0001929_abnormal_gametogenesis0.64478331
89MP0003448_altered_tumor_morphology0.62761944
90MP0006035_abnormal_mitochondrial_morpho0.62477235
91MP0008872_abnormal_physiological_respon0.60729349
92MP0005253_abnormal_eye_physiology0.59476316
93MP0000858_altered_metastatic_potential0.58240724
94MP0003943_abnormal_hepatobiliary_system0.57553951
95MP0001661_extended_life_span0.57229855
96MP0002876_abnormal_thyroid_physiology0.56917045
97MP0002332_abnormal_exercise_endurance0.56679385
98MP0003693_abnormal_embryo_hatching0.55905508
99MP0005166_decreased_susceptibility_to0.55621415
100MP0001905_abnormal_dopamine_level0.55568306

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.16633188
2T lymphocytopenia (HP:0005403)3.97817179
3Elevated erythrocyte sedimentation rate (HP:0003565)3.90104622
4Abnormality of T cell number (HP:0011839)3.83433017
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77936973
6Aplastic anemia (HP:0001915)3.77727362
73-Methylglutaconic aciduria (HP:0003535)3.67861010
8Abnormality of the prostate (HP:0008775)3.44390126
9Abnormality of T cells (HP:0002843)3.31610548
10Agammaglobulinemia (HP:0004432)3.29795220
11Severe combined immunodeficiency (HP:0004430)3.25291606
12Encephalitis (HP:0002383)3.23579344
13Panhypogammaglobulinemia (HP:0003139)3.22350998
14Hypoproteinemia (HP:0003075)3.16244655
15Increased IgM level (HP:0003496)3.09513860
16Stomatitis (HP:0010280)3.06790093
17Myositis (HP:0100614)3.04316178
18Meningitis (HP:0001287)2.95897128
19Acute necrotizing encephalopathy (HP:0006965)2.90880496
20Mitochondrial inheritance (HP:0001427)2.89522294
21Optic neuritis (HP:0100653)2.89455000
22Retrobulbar optic neuritis (HP:0100654)2.89455000
23IgM deficiency (HP:0002850)2.77701683
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.76044040
25Increased CSF lactate (HP:0002490)2.75341195
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.73621223
27Hypoplasia of the fovea (HP:0007750)2.73621223
28Abnormal mitochondria in muscle tissue (HP:0008316)2.73490068
29Abnormality of eosinophils (HP:0001879)2.73164231
30Abnormal rod and cone electroretinograms (HP:0008323)2.69792010
31Abnormality of the fovea (HP:0000493)2.69718955
32Obstructive lung disease (HP:0006536)2.66166507
33Chronic obstructive pulmonary disease (HP:0006510)2.66166507
34Increased intramyocellular lipid droplets (HP:0012240)2.64268256
35Type I transferrin isoform profile (HP:0003642)2.60648406
36Combined immunodeficiency (HP:0005387)2.56536101
37Abnormality of T cell physiology (HP:0011840)2.51735066
38Hepatocellular necrosis (HP:0001404)2.50449637
39Increased serum lactate (HP:0002151)2.49030450
40Chronic mucocutaneous candidiasis (HP:0002728)2.47936069
41Recurrent cutaneous fungal infections (HP:0011370)2.47936069
42Orchitis (HP:0100796)2.45561679
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45021899
44Hepatic necrosis (HP:0002605)2.43041204
45Abnormality of male internal genitalia (HP:0000022)2.42901518
46Progressive macrocephaly (HP:0004481)2.41837419
47Renal cortical cysts (HP:0000803)2.38957232
48Acute encephalopathy (HP:0006846)2.36700555
49Abnormality of B cell number (HP:0010975)2.36011217
50Vasculitis (HP:0002633)2.35086337
51Attenuation of retinal blood vessels (HP:0007843)2.35011192
52Reduced antithrombin III activity (HP:0001976)2.34194023
53Type 2 muscle fiber atrophy (HP:0003554)2.33502641
54Congenital stationary night blindness (HP:0007642)2.32326509
55Increased hepatocellular lipid droplets (HP:0006565)2.32313296
56Abolished electroretinogram (ERG) (HP:0000550)2.30993033
57Recurrent bronchitis (HP:0002837)2.30277032
58Eosinophilia (HP:0001880)2.28519788
59Pulmonary infiltrates (HP:0002113)2.27790386
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27783517
61Gonadal dysgenesis (HP:0000133)2.27056762
62Glomerulopathy (HP:0100820)2.26054091
63Gangrene (HP:0100758)2.22000343
64Recurrent fungal infections (HP:0002841)2.20908616
65Increased muscle lipid content (HP:0009058)2.20461052
66Keratoconjunctivitis sicca (HP:0001097)2.20320685
67Lactic acidosis (HP:0003128)2.20176846
68Chronic diarrhea (HP:0002028)2.18185683
69Muscle fiber atrophy (HP:0100295)2.17664237
70Hemoptysis (HP:0002105)2.17653231
71Cerebral edema (HP:0002181)2.17164288
72Tongue fasciculations (HP:0001308)2.16254891
73Keratoconjunctivitis (HP:0001096)2.16088354
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14849218
75Abnormality of alanine metabolism (HP:0010916)2.14849218
76Hyperalaninemia (HP:0003348)2.14849218
77B lymphocytopenia (HP:0010976)2.13479562
78Hypoplasia of the thymus (HP:0000778)2.11600211
79Autoimmune hemolytic anemia (HP:0001890)2.07884903
80Joint swelling (HP:0001386)2.06339068
81Thyroiditis (HP:0100646)2.03730358
82Leukocytosis (HP:0001974)2.03696877
83Keratitis (HP:0000491)2.03175745
84Prostate neoplasm (HP:0100787)2.02417893
85Recurrent viral infections (HP:0004429)2.00307574
86Granulocytopenia (HP:0001913)1.99366829
87Renal Fanconi syndrome (HP:0001994)1.99172010
88Nemaline bodies (HP:0003798)1.98858662
89Polyneuropathy (HP:0001271)1.98171781
90Generalized aminoaciduria (HP:0002909)1.96712892
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96570178
92Abnormal protein N-linked glycosylation (HP:0012347)1.96570178
93Abnormal protein glycosylation (HP:0012346)1.96570178
94Abnormal glycosylation (HP:0012345)1.96570178
95Aplasia/hypoplasia of the uterus (HP:0008684)1.96265470
96Optic disc pallor (HP:0000543)1.92118386
97Lipid accumulation in hepatocytes (HP:0006561)1.91497195
98Microretrognathia (HP:0000308)1.91437592
99Chest pain (HP:0100749)1.90582522
100Decreased central vision (HP:0007663)1.89615376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.68455531
2TXK5.36911209
3TESK24.41855881
4TSSK62.73880337
5BCKDK2.51616358
6KDR2.47480814
7MAP3K122.36000882
8EIF2AK32.30179887
9MAP4K12.23332823
10VRK22.14698457
11TAOK31.84603282
12SCYL21.83445000
13NUAK11.79328015
14PASK1.73304466
15MAPK151.72153819
16KIT1.70633156
17CSF1R1.56882776
18VRK11.54637767
19TBK11.50767213
20ITK1.46361485
21MAPKAPK31.45694328
22FES1.42024282
23IKBKE1.37918880
24IKBKB1.34008450
25SYK1.30574170
26MST41.27818679
27JAK31.22761723
28MAPKAPK51.21373363
29GRK11.20299532
30SIK31.18511004
31GRK61.14310190
32TEC1.13007534
33MARK31.12377211
34IRAK41.11476330
35MAP3K141.07117462
36MAP4K21.06677149
37MUSK1.06174140
38TESK11.05846005
39PIK3CG1.03848899
40LCK1.03761469
41BTK0.99468653
42OXSR10.97599319
43ZAK0.96282281
44BMPR20.93422226
45BUB10.93156442
46TLK10.92194535
47LYN0.89805023
48MAP2K20.88023035
49MATK0.83114569
50LIMK10.82471990
51CDK30.78836126
52ZAP700.76424207
53DAPK10.75972201
54TNK20.75531774
55STK160.75348706
56PRKCQ0.73062742
57FLT30.70544671
58RPS6KA40.67647827
59MYLK0.62704762
60CSK0.62333488
61NME20.59833987
62EIF2AK10.56434132
63MAP3K110.56247611
64ADRBK20.55956368
65RPS6KB20.54613132
66ILK0.52265746
67EIF2AK20.51226340
68PHKG10.50263409
69PHKG20.50263409
70CSNK1G10.49414052
71GRK70.49269979
72OBSCN0.46722600
73CSNK1G30.45535274
74INSRR0.45405707
75NEK10.45203899
76PLK40.44744754
77MAPK130.44357269
78HCK0.43624255
79RPS6KA50.43594489
80MAPKAPK20.42380784
81CSNK1G20.40973625
82STK100.40741030
83WNK40.40679336
84MAP2K60.37983347
85MAPK110.37484990
86NLK0.36417369
87ACVR1B0.35040280
88SRPK10.34091106
89CAMKK20.31906276
90PIM10.30764888
91IGF1R0.30321594
92CDK40.29123528
93TAOK20.28585777
94ABL10.28273743
95TYK20.28140966
96HIPK20.27153069
97WEE10.26514137
98MAPK70.26252918
99PLK30.22077857
100CSNK2A10.21173612

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.80067547
2Allograft rejection_Homo sapiens_hsa053303.73893859
3Asthma_Homo sapiens_hsa053103.69741057
4Autoimmune thyroid disease_Homo sapiens_hsa053203.68440226
5Primary immunodeficiency_Homo sapiens_hsa053403.65130856
6Graft-versus-host disease_Homo sapiens_hsa053323.63756092
7Antigen processing and presentation_Homo sapiens_hsa046123.22634358
8Type I diabetes mellitus_Homo sapiens_hsa049402.95409266
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.88198360
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51297880
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28319758
12Protein export_Homo sapiens_hsa030602.10519389
13Viral myocarditis_Homo sapiens_hsa054162.06907786
14Ribosome_Homo sapiens_hsa030101.98516508
15Hematopoietic cell lineage_Homo sapiens_hsa046401.98404838
16Rheumatoid arthritis_Homo sapiens_hsa053231.91066795
17RNA polymerase_Homo sapiens_hsa030201.86458218
18Leishmaniasis_Homo sapiens_hsa051401.66657487
19T cell receptor signaling pathway_Homo sapiens_hsa046601.63930239
20Oxidative phosphorylation_Homo sapiens_hsa001901.60741944
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48900574
22Herpes simplex infection_Homo sapiens_hsa051681.42072367
23Measles_Homo sapiens_hsa051621.42057985
24Parkinsons disease_Homo sapiens_hsa050121.40301955
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.39699126
26Legionellosis_Homo sapiens_hsa051341.36739781
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34960223
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24687642
29Base excision repair_Homo sapiens_hsa034101.21276830
30One carbon pool by folate_Homo sapiens_hsa006701.16741022
31Basal transcription factors_Homo sapiens_hsa030221.16536277
32Epstein-Barr virus infection_Homo sapiens_hsa051691.15592423
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12676711
34Pyrimidine metabolism_Homo sapiens_hsa002401.09758064
35Staphylococcus aureus infection_Homo sapiens_hsa051500.99961154
36SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91110045
37RNA degradation_Homo sapiens_hsa030180.90023034
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.89768404
39Regulation of autophagy_Homo sapiens_hsa041400.89754535
40Influenza A_Homo sapiens_hsa051640.88861143
41Non-homologous end-joining_Homo sapiens_hsa034500.88436774
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88356902
43Spliceosome_Homo sapiens_hsa030400.88161372
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87189980
45Shigellosis_Homo sapiens_hsa051310.87162136
46DNA replication_Homo sapiens_hsa030300.86695935
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86587052
48Sulfur metabolism_Homo sapiens_hsa009200.84453008
49RNA transport_Homo sapiens_hsa030130.82491285
50Nucleotide excision repair_Homo sapiens_hsa034200.81724705
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80363116
52Mismatch repair_Homo sapiens_hsa034300.79950608
53Homologous recombination_Homo sapiens_hsa034400.79462950
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79042251
55Toxoplasmosis_Homo sapiens_hsa051450.73373007
56Purine metabolism_Homo sapiens_hsa002300.71309968
57Fanconi anemia pathway_Homo sapiens_hsa034600.69085193
58Huntingtons disease_Homo sapiens_hsa050160.67491588
59Tuberculosis_Homo sapiens_hsa051520.65343443
60Phototransduction_Homo sapiens_hsa047440.62957630
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.61158786
62Alzheimers disease_Homo sapiens_hsa050100.57445138
63Malaria_Homo sapiens_hsa051440.56356746
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56077414
65B cell receptor signaling pathway_Homo sapiens_hsa046620.55916503
66HTLV-I infection_Homo sapiens_hsa051660.53669034
67Systemic lupus erythematosus_Homo sapiens_hsa053220.52634366
68Selenocompound metabolism_Homo sapiens_hsa004500.52316122
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51968533
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48833371
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48517447
72Peroxisome_Homo sapiens_hsa041460.46926051
73Glutathione metabolism_Homo sapiens_hsa004800.46123516
74Fatty acid elongation_Homo sapiens_hsa000620.45648724
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43413507
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42934445
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.42654677
78Osteoclast differentiation_Homo sapiens_hsa043800.42359272
79Propanoate metabolism_Homo sapiens_hsa006400.41898100
80Salmonella infection_Homo sapiens_hsa051320.39060456
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38308986
82Arachidonic acid metabolism_Homo sapiens_hsa005900.37574408
83Nitrogen metabolism_Homo sapiens_hsa009100.36697066
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.34885982
85Pentose phosphate pathway_Homo sapiens_hsa000300.34666397
86Sulfur relay system_Homo sapiens_hsa041220.34002631
87Olfactory transduction_Homo sapiens_hsa047400.31768645
88African trypanosomiasis_Homo sapiens_hsa051430.28524243
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28009055
90TNF signaling pathway_Homo sapiens_hsa046680.27527655
91p53 signaling pathway_Homo sapiens_hsa041150.26192944
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.25039023
93Viral carcinogenesis_Homo sapiens_hsa052030.22869701
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22584403
95Linoleic acid metabolism_Homo sapiens_hsa005910.21006998
96Caffeine metabolism_Homo sapiens_hsa002320.20833056
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20321295
98Apoptosis_Homo sapiens_hsa042100.19041744
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18803852
100Metabolic pathways_Homo sapiens_hsa011000.18599715

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