EIF3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.26579634
2maturation of SSU-rRNA (GO:0030490)4.91278769
3ribosomal small subunit assembly (GO:0000028)4.88362903
4DNA strand elongation involved in DNA replication (GO:0006271)4.65086068
5* formation of translation preinitiation complex (GO:0001731)4.63322130
6nucleobase biosynthetic process (GO:0046112)4.56712244
7viral transcription (GO:0019083)4.46727954
8DNA strand elongation (GO:0022616)4.41198160
9translational termination (GO:0006415)4.39624226
10purine nucleobase biosynthetic process (GO:0009113)4.34054723
11telomere maintenance via semi-conservative replication (GO:0032201)4.32147623
12ribosomal large subunit biogenesis (GO:0042273)4.24075393
13DNA replication initiation (GO:0006270)4.21104491
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.17475943
15translational elongation (GO:0006414)4.10554158
16ribosomal small subunit biogenesis (GO:0042274)4.09327694
17ribosome biogenesis (GO:0042254)4.07771729
18ribonucleoprotein complex biogenesis (GO:0022613)4.05774491
19* translational initiation (GO:0006413)4.03808191
20ribosome assembly (GO:0042255)3.98683376
21proteasome assembly (GO:0043248)3.97599069
22DNA replication checkpoint (GO:0000076)3.95599671
23DNA unwinding involved in DNA replication (GO:0006268)3.85760389
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82786117
25telomere maintenance via recombination (GO:0000722)3.79247398
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.72987209
27cotranslational protein targeting to membrane (GO:0006613)3.71069876
28protein targeting to ER (GO:0045047)3.70806557
29rRNA processing (GO:0006364)3.69135808
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69018004
31spliceosomal snRNP assembly (GO:0000387)3.67594581
32folic acid-containing compound biosynthetic process (GO:0009396)3.65598316
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60448546
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58273714
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57947889
36mitotic metaphase plate congression (GO:0007080)3.57318128
37rRNA metabolic process (GO:0016072)3.56881979
38pseudouridine synthesis (GO:0001522)3.56753248
39IMP biosynthetic process (GO:0006188)3.56082603
40GDP-mannose metabolic process (GO:0019673)3.53890576
41peptidyl-arginine omega-N-methylation (GO:0035247)3.53208477
42DNA replication-dependent nucleosome assembly (GO:0006335)3.51859015
43DNA replication-dependent nucleosome organization (GO:0034723)3.51859015
44mitotic nuclear envelope disassembly (GO:0007077)3.51092619
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.50784034
46protein localization to endoplasmic reticulum (GO:0070972)3.50661622
47telomere maintenance via telomere lengthening (GO:0010833)3.49346649
48cellular protein complex disassembly (GO:0043624)3.48816326
49mitotic recombination (GO:0006312)3.48709893
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.47238958
51viral life cycle (GO:0019058)3.45151659
52protein localization to kinetochore (GO:0034501)3.45114611
53rRNA modification (GO:0000154)3.41886980
54folic acid metabolic process (GO:0046655)3.40589742
55negative regulation of ligase activity (GO:0051352)3.40446043
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40446043
57* translation (GO:0006412)3.40159625
58proline biosynthetic process (GO:0006561)3.35003622
59negative regulation of erythrocyte differentiation (GO:0045647)3.33919142
60chromatin remodeling at centromere (GO:0031055)3.28964341
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28955987
62CENP-A containing nucleosome assembly (GO:0034080)3.28460511
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.26926210
64protein maturation by protein folding (GO:0022417)3.25180907
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23188396
66nuclear envelope disassembly (GO:0051081)3.21549753
67membrane disassembly (GO:0030397)3.21549753
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19063822
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19063822
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18767117
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18767117
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18767117
73protein complex disassembly (GO:0043241)3.18613614
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.18139868
75termination of RNA polymerase III transcription (GO:0006386)3.18139868
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18082327
77regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17503994
78positive regulation of gamma-delta T cell activation (GO:0046645)3.17495184
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16332685
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.16332685
81regulation of translational fidelity (GO:0006450)3.15917897
82transcription-coupled nucleotide-excision repair (GO:0006283)3.15773800
83cellular component biogenesis (GO:0044085)3.15396058
84viral mRNA export from host cell nucleus (GO:0046784)3.14238069
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12850121
86regulation of cellular amino acid metabolic process (GO:0006521)3.12499307
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.11350464
88IMP metabolic process (GO:0046040)3.11052734
89COPI coating of Golgi vesicle (GO:0048205)3.09669908
90Golgi transport vesicle coating (GO:0048200)3.09669908
91G1/S transition of mitotic cell cycle (GO:0000082)3.07540875
92cell cycle G1/S phase transition (GO:0044843)3.07540875
93DNA replication-independent nucleosome organization (GO:0034724)3.07009496
94DNA replication-independent nucleosome assembly (GO:0006336)3.07009496
95macromolecular complex disassembly (GO:0032984)3.04667670
96positive regulation of ligase activity (GO:0051351)3.03116976
97metaphase plate congression (GO:0051310)3.02682533
98protein localization to chromosome, centromeric region (GO:0071459)3.01911293
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.00765626
100pentose-phosphate shunt (GO:0006098)2.96962001
101UV protection (GO:0009650)2.96103702
102cullin deneddylation (GO:0010388)2.91528388
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90951230
104spliceosomal complex assembly (GO:0000245)2.88829190
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.88572761
106NIK/NF-kappaB signaling (GO:0038061)2.88041819
107histone arginine methylation (GO:0034969)2.87471463
108protein targeting to membrane (GO:0006612)2.86490987
109positive thymic T cell selection (GO:0045059)2.86347554
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.86304100
111kinetochore organization (GO:0051383)2.84612363
112pinocytosis (GO:0006907)2.84284219
113mRNA catabolic process (GO:0006402)2.84058120
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83736850
115RNA catabolic process (GO:0006401)2.83278789
116establishment of integrated proviral latency (GO:0075713)2.82665984
117protein deneddylation (GO:0000338)2.81089070
118ncRNA processing (GO:0034470)2.80274204
119kinetochore assembly (GO:0051382)2.79846435
120L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79496327
121mitotic nuclear envelope reassembly (GO:0007084)2.79418239
122nuclear envelope reassembly (GO:0031468)2.79418239
1233-UTR-mediated mRNA stabilization (GO:0070935)2.79338961
124modulation by virus of host process (GO:0019054)2.75960104
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69799996
126thymic T cell selection (GO:0045061)2.62273549
127regulation of translational termination (GO:0006449)2.61964244
128peptidyl-arginine methylation (GO:0018216)2.61872314
129peptidyl-arginine N-methylation (GO:0035246)2.61872314
130apoptotic process involved in morphogenesis (GO:0060561)2.57668220
131T cell apoptotic process (GO:0070231)2.55165169
132negative regulation of B cell apoptotic process (GO:0002903)2.54540458
133purine deoxyribonucleotide catabolic process (GO:0009155)2.53642914
134NADH metabolic process (GO:0006734)2.52657398
135regulation of superoxide anion generation (GO:0032928)2.49999581
136modulation by symbiont of host cellular process (GO:0044068)2.48774872
137nucleobase-containing small molecule interconversion (GO:0015949)2.48351537
138NADPH regeneration (GO:0006740)2.47673592
139negative regulation of DNA-templated transcription, elongation (GO:0032785)2.47453106
140pentose metabolic process (GO:0019321)2.46323397
141regulation of defense response to virus by virus (GO:0050690)2.45312913
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43076320
143mannose metabolic process (GO:0006013)2.41862038
144mitochondrial fusion (GO:0008053)2.41531578
145glucose catabolic process (GO:0006007)2.41166134
146regulation of gamma-delta T cell differentiation (GO:0045586)2.38603846
147regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38352417
148ncRNA 3-end processing (GO:0043628)2.38072225
149viral protein processing (GO:0019082)2.37962248
150cellular response to interleukin-4 (GO:0071353)2.37915385
151antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34090000
152rRNA transcription (GO:0009303)2.33323751
153Arp2/3 complex-mediated actin nucleation (GO:0034314)2.32872904
154antigen processing and presentation of endogenous antigen (GO:0019883)2.32563662
155negative regulation of cell size (GO:0045792)2.31503132
156proline metabolic process (GO:0006560)2.30074665
157iron-sulfur cluster assembly (GO:0016226)2.29742868
158metallo-sulfur cluster assembly (GO:0031163)2.29742868
159guanosine-containing compound biosynthetic process (GO:1901070)2.29206892
160negative regulation of necroptotic process (GO:0060546)2.24489576
161snRNA metabolic process (GO:0016073)2.24226487
162nucleotide salvage (GO:0043173)2.23276675
163mature B cell differentiation involved in immune response (GO:0002313)2.21692721
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.20645650
165positive regulation by organism of defense response of other organism involved in symbiotic interact2.20645650
166modulation by symbiont of host immune response (GO:0052553)2.20645650
167modulation by symbiont of host defense response (GO:0052031)2.20645650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.74587805
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41969276
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09985158
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16166989
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12084686
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.06727167
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.05645725
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03870971
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03289228
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.00603126
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99717561
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.90104819
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88857287
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77736651
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64065380
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56899317
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50133385
18XRN2_22483619_ChIP-Seq_HELA_Human2.44581800
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33216307
20* VDR_23849224_ChIP-Seq_CD4+_Human2.27933465
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21251878
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13492136
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11714642
24DCP1A_22483619_ChIP-Seq_HELA_Human2.10110172
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06462950
26* GABP_19822575_ChIP-Seq_HepG2_Human1.99426837
27LXR_22292898_ChIP-Seq_THP-1_Human1.97923067
28FOXP3_21729870_ChIP-Seq_TREG_Human1.96161123
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.91393507
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89618114
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85436166
32TTF2_22483619_ChIP-Seq_HELA_Human1.85250132
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84155621
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79224330
35AR_21909140_ChIP-Seq_LNCAP_Human1.77409920
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.77342261
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77171067
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75760759
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75189746
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74797204
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73859258
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73544771
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65935428
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64849938
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.64729859
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64228536
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62544243
48CIITA_25753668_ChIP-Seq_RAJI_Human1.62131882
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61955587
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60814135
51MAF_26560356_Chip-Seq_TH1_Human1.57441295
52* MAF_26560356_Chip-Seq_TH2_Human1.54269569
53MYC_22102868_ChIP-Seq_BL_Human1.53733261
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.53556100
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52290350
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52224254
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.51951991
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49961208
59KDM5A_27292631_Chip-Seq_BREAST_Human1.49526346
60P68_20966046_ChIP-Seq_HELA_Human1.47479909
61RACK7_27058665_Chip-Seq_MCF-7_Human1.46846378
62UTX_26944678_Chip-Seq_JUKART_Human1.46415102
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45044882
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44338601
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41759921
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41372833
67VDR_24763502_ChIP-Seq_THP-1_Human1.40981480
68ELK1_19687146_ChIP-ChIP_HELA_Human1.40290921
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.39716178
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.37222474
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36929987
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36612738
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35407337
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34900034
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34498973
76KDM2B_26808549_Chip-Seq_DND41_Human1.32906366
77TCF7_22412390_ChIP-Seq_EML_Mouse1.32464118
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.31669850
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28954747
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26888458
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.26601531
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25151960
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23718026
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23702929
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23456739
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21461952
87BCOR_27268052_Chip-Seq_Bcells_Human1.20769890
88BCL6_27268052_Chip-Seq_Bcells_Human1.20199611
89NCOR1_26117541_ChIP-Seq_K562_Human1.19952497
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.19806060
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18358404
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16486203
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16465515
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15714950
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15711152
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14782247
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14691009
98* CTCF_26484167_Chip-Seq_Bcells_Mouse1.12737435
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12729434
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12475587
101TFEB_21752829_ChIP-Seq_HELA_Human1.12404033
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12379479
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11510191
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11081968
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.10955958
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10327692
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08992444
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08514336
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07705404
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06846369
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.06701733
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06640112
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06337299
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06087225
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06081483
116VDR_21846776_ChIP-Seq_THP-1_Human1.02433182
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01808520
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01493736
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01033493
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99615987
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.98550281
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98310447
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97968320
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97741747
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93961849
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92007250
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89500563
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.88992393
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88637589
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87971784
131MYC_18940864_ChIP-ChIP_HL60_Human0.87229211
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86612242
133* SPI1_23547873_ChIP-Seq_NB4_Human0.86176050
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83859364
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83407927
136SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82793103
137ZNF263_19887448_ChIP-Seq_K562_Human0.79357892
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.77552486
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77365635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.92075779
2MP0004957_abnormal_blastocyst_morpholog4.73658323
3MP0003111_abnormal_nucleus_morphology4.34017442
4MP0010094_abnormal_chromosome_stability4.22658951
5MP0003077_abnormal_cell_cycle3.88369636
6MP0008058_abnormal_DNA_repair3.29544830
7MP0008057_abnormal_DNA_replication3.21103236
8MP0005451_abnormal_body_composition3.02606377
9MP0008007_abnormal_cellular_replicative2.97158817
10MP0005058_abnormal_lysosome_morphology2.80723369
11MP0008932_abnormal_embryonic_tissue2.69273525
12MP0003436_decreased_susceptibility_to2.51647387
13MP0003123_paternal_imprinting2.47512363
14MP0002396_abnormal_hematopoietic_system2.45052489
15MP0003806_abnormal_nucleotide_metabolis2.44769410
16MP0001730_embryonic_growth_arrest2.44074995
17MP0010352_gastrointestinal_tract_polyps2.21824994
18MP0003786_premature_aging2.18290692
19MP0000350_abnormal_cell_proliferation2.15709138
20MP0004185_abnormal_adipocyte_glucose1.92592970
21MP0003705_abnormal_hypodermis_morpholog1.86443165
22MP0002877_abnormal_melanocyte_morpholog1.86201076
23MP0000490_abnormal_crypts_of1.80897950
24MP0003718_maternal_effect1.78276224
25MP0008877_abnormal_DNA_methylation1.76503943
26MP0003303_peritoneal_inflammation1.76480318
27MP0001697_abnormal_embryo_size1.69353352
28MP0001672_abnormal_embryogenesis/_devel1.65040548
29MP0005380_embryogenesis_phenotype1.65040548
30MP0002080_prenatal_lethality1.64662648
31MP0005025_abnormal_response_to1.62323818
32MP0001873_stomach_inflammation1.60049801
33MP0001835_abnormal_antigen_presentation1.59880000
34MP0009333_abnormal_splenocyte_physiolog1.57339310
35MP0010030_abnormal_orbit_morphology1.54806028
36MP0003191_abnormal_cellular_cholesterol1.53685119
37MP0005000_abnormal_immune_tolerance1.53624025
38MP0010307_abnormal_tumor_latency1.51976683
39MP0003984_embryonic_growth_retardation1.51877458
40MP0000313_abnormal_cell_death1.51402461
41MP0002420_abnormal_adaptive_immunity1.50546838
42MP0001819_abnormal_immune_cell1.49227095
43MP0002019_abnormal_tumor_incidence1.48852012
44MP0002088_abnormal_embryonic_growth/wei1.48175868
45MP0005671_abnormal_response_to1.47426477
46MP0003186_abnormal_redox_activity1.47297763
47MP0001800_abnormal_humoral_immune1.46615248
48MP0005464_abnormal_platelet_physiology1.46443253
49MP0002723_abnormal_immune_serum1.44016423
50MP0001661_extended_life_span1.42307533
51MP0005397_hematopoietic_system_phenotyp1.39548655
52MP0001545_abnormal_hematopoietic_system1.39548655
53MP0002132_abnormal_respiratory_system1.38360253
54MP0004947_skin_inflammation1.36968118
55MP0002452_abnormal_antigen_presenting1.36721471
56MP0002085_abnormal_embryonic_tissue1.36711652
57MP0002419_abnormal_innate_immunity1.33029762
58MP0003567_abnormal_fetal_cardiomyocyte1.29672962
59MP0004233_abnormal_muscle_weight1.29295869
60MP0004808_abnormal_hematopoietic_stem1.28841586
61MP0002086_abnormal_extraembryonic_tissu1.28709862
62MP0002148_abnormal_hypersensitivity_rea1.28430373
63MP0000678_abnormal_parathyroid_gland1.28293457
64MP0001790_abnormal_immune_system1.26418443
65MP0005387_immune_system_phenotype1.26418443
66MP0000747_muscle_weakness1.24463218
67MP0003763_abnormal_thymus_physiology1.23145841
68MP0005083_abnormal_biliary_tract1.22256827
69MP0004858_abnormal_nervous_system1.21729645
70MP0002084_abnormal_developmental_patter1.21077255
71MP0004197_abnormal_fetal_growth/weight/1.20694646
72MP0000358_abnormal_cell_content/1.20156229
73MP0002210_abnormal_sex_determination1.17278709
74MP0003453_abnormal_keratinocyte_physiol1.15162454
75MP0003315_abnormal_perineum_morphology1.14126427
76MP0006036_abnormal_mitochondrial_physio1.12727567
77MP0005330_cardiomyopathy1.10957796
78MP0003172_abnormal_lysosome_physiology1.10347750
79MP0001145_abnormal_male_reproductive1.08264380
80MP0000759_abnormal_skeletal_muscle1.07563798
81MP0000751_myopathy1.06542940
82MP0009785_altered_susceptibility_to1.06243505
83MP0002796_impaired_skin_barrier1.05396590
84MP0001849_ear_inflammation1.05324328
85MP0002722_abnormal_immune_system1.03580336
86MP0001293_anophthalmia1.03360980
87MP0002160_abnormal_reproductive_system1.02945446
88MP0000703_abnormal_thymus_morphology1.02109712
89MP0010155_abnormal_intestine_physiology1.02061227
90MP0002398_abnormal_bone_marrow1.00604927
91MP0002653_abnormal_ependyma_morphology1.00102764
92MP0000733_abnormal_muscle_development1.00035726
93MP0000858_altered_metastatic_potential0.98454018
94MP0005666_abnormal_adipose_tissue0.98379470
95MP0000689_abnormal_spleen_morphology0.97952958
96MP0003300_gastrointestinal_ulcer0.97337696
97MP0000003_abnormal_adipose_tissue0.94792831
98MP0006035_abnormal_mitochondrial_morpho0.94757037
99MP0001929_abnormal_gametogenesis0.94638207
100MP0001845_abnormal_inflammatory_respons0.93370819
101MP0001853_heart_inflammation0.93301120
102MP0006054_spinal_hemorrhage0.92623059
103MP0008469_abnormal_protein_level0.92085449
104MP0003221_abnormal_cardiomyocyte_apopto0.92072993
105MP0001533_abnormal_skeleton_physiology0.91928356
106MP0009672_abnormal_birth_weight0.88701617
107MP0000653_abnormal_sex_gland0.88565755
108MP0005375_adipose_tissue_phenotype0.88436434
109MP0001348_abnormal_lacrimal_gland0.86126826
110MP0003119_abnormal_digestive_system0.86124186
111MP0005076_abnormal_cell_differentiation0.85893471
112MP0002429_abnormal_blood_cell0.85424177
113MP0003890_abnormal_embryonic-extraembry0.84416427
114MP0004381_abnormal_hair_follicle0.84321431
115MP0004087_abnormal_muscle_fiber0.81582169
116MP0005389_reproductive_system_phenotype0.80760874
117MP0000537_abnormal_urethra_morphology0.80062379
118MP0003656_abnormal_erythrocyte_physiolo0.78144275
119MP0009931_abnormal_skin_appearance0.77978427
120MP0005384_cellular_phenotype0.77902043
121MP0005023_abnormal_wound_healing0.77811839
122MP0004133_heterotaxia0.77387295
123MP0000750_abnormal_muscle_regeneration0.76854718
124MP0003866_abnormal_defecation0.76712534
125MP0008438_abnormal_cutaneous_collagen0.75894378
126MP0000343_altered_response_to0.75668424
127MP0003566_abnormal_cell_adhesion0.75385936
128MP0002060_abnormal_skin_morphology0.73390484
129MP0009379_abnormal_foot_pigmentation0.73366477
130MP0005075_abnormal_melanosome_morpholog0.73036191
131MP0009053_abnormal_anal_canal0.71370759
132MP0000477_abnormal_intestine_morphology0.68734710
133MP0002111_abnormal_tail_morphology0.68466353
134MP0003941_abnormal_skin_development0.67944267
135MP0003121_genomic_imprinting0.67932746
136MP0001119_abnormal_female_reproductive0.66942625
137MP0001764_abnormal_homeostasis0.66819054
138MP0005621_abnormal_cell_physiology0.66602188
139MP0005377_hearing/vestibular/ear_phenot0.66495080
140MP0003878_abnormal_ear_physiology0.66495080
141MP0000716_abnormal_immune_system0.65662947
142MP0005266_abnormal_metabolism0.62948519
143MP0006292_abnormal_olfactory_placode0.62793401
144MP0001919_abnormal_reproductive_system0.61048497
145MP0009278_abnormal_bone_marrow0.60358004
146MP0009840_abnormal_foam_cell0.59582946
147MP0000598_abnormal_liver_morphology0.58318298
148MP0004147_increased_porphyrin_level0.57540612
149MP0001727_abnormal_embryo_implantation0.54493342
150MP0002405_respiratory_system_inflammati0.54171200
151MP0005501_abnormal_skin_physiology0.54083286
152MP0002269_muscular_atrophy0.52862311
153MP0001915_intracranial_hemorrhage0.50854976
154MP0008260_abnormal_autophagy0.50324781
155MP0000685_abnormal_immune_system0.49025672
156MP0008789_abnormal_olfactory_epithelium0.48990600

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.36081118
2Abnormal number of erythroid precursors (HP:0012131)5.14765505
3Birth length less than 3rd percentile (HP:0003561)4.67135267
4Reticulocytopenia (HP:0001896)4.60364897
5Oral leukoplakia (HP:0002745)4.08623273
6Breast hypoplasia (HP:0003187)3.88440776
7Ragged-red muscle fibers (HP:0003200)3.77135294
8Abnormality of the anterior horn cell (HP:0006802)3.64900236
9Degeneration of anterior horn cells (HP:0002398)3.64900236
10Carpal bone hypoplasia (HP:0001498)3.61883302
11Rough bone trabeculation (HP:0100670)3.56384954
12Macrocytic anemia (HP:0001972)3.54207602
13Cerebral hypomyelination (HP:0006808)3.53857714
14Selective tooth agenesis (HP:0001592)3.45696576
15Colon cancer (HP:0003003)3.32007769
16Trismus (HP:0000211)3.27796652
17Multiple enchondromatosis (HP:0005701)3.26373169
18Pallor (HP:0000980)3.22479984
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.21980611
20Myopathic facies (HP:0002058)3.21718252
21Microretrognathia (HP:0000308)3.14649507
22Aplastic anemia (HP:0001915)3.11974471
23Patellar aplasia (HP:0006443)3.09975013
24Aplasia/Hypoplasia of the patella (HP:0006498)2.97174041
25Vertebral compression fractures (HP:0002953)2.93920296
26Absent thumb (HP:0009777)2.89220727
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81697119
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81697119
29Hypertensive crisis (HP:0100735)2.75073879
30Premature ovarian failure (HP:0008209)2.73277144
3111 pairs of ribs (HP:0000878)2.71601678
32Cholecystitis (HP:0001082)2.67318559
33Abnormal gallbladder physiology (HP:0012438)2.67318559
34Premature graying of hair (HP:0002216)2.60839798
35Neoplasm of the pancreas (HP:0002894)2.60486489
36Increased intramyocellular lipid droplets (HP:0012240)2.59688912
37Distal lower limb muscle weakness (HP:0009053)2.58528141
38Increased muscle lipid content (HP:0009058)2.57699330
39Eczematoid dermatitis (HP:0000976)2.56090781
40Abnormality of the preputium (HP:0100587)2.54350120
41Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.51294722
42Abnormal trabecular bone morphology (HP:0100671)2.50565386
43Meckel diverticulum (HP:0002245)2.49371190
44Chronic obstructive pulmonary disease (HP:0006510)2.48194965
45Obstructive lung disease (HP:0006536)2.48194965
46Progressive muscle weakness (HP:0003323)2.47959690
47Secondary amenorrhea (HP:0000869)2.46221734
48Achilles tendon contracture (HP:0001771)2.45733912
49Medulloblastoma (HP:0002885)2.45574888
50Increased connective tissue (HP:0009025)2.45085472
51Increased serum lactate (HP:0002151)2.43720110
52Abnormality of the ileum (HP:0001549)2.42621092
53Testicular atrophy (HP:0000029)2.41977424
54Ependymoma (HP:0002888)2.41220125
55Thrombocytosis (HP:0001894)2.41025983
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40018539
57Type I transferrin isoform profile (HP:0003642)2.35469322
58Chromsome breakage (HP:0040012)2.33101676
59Increased serum ferritin (HP:0003281)2.30937518
60Elevated erythrocyte sedimentation rate (HP:0003565)2.29885598
61Colitis (HP:0002583)2.29102204
62Broad distal phalanx of finger (HP:0009836)2.28319927
63Impulsivity (HP:0100710)2.28267582
64Distal lower limb amyotrophy (HP:0008944)2.26805463
65Sparse eyelashes (HP:0000653)2.24507445
66Rhabdomyolysis (HP:0003201)2.24178459
67Cellular immunodeficiency (HP:0005374)2.24153766
68Hyperacusis (HP:0010780)2.23645371
69Bone marrow hypocellularity (HP:0005528)2.22174215
70Agnosia (HP:0010524)2.21038464
71Progressive external ophthalmoplegia (HP:0000590)2.20942029
72Abnormality of macrophages (HP:0004311)2.20773490
73Exercise-induced myalgia (HP:0003738)2.20412234
74Abnormality of chromosome stability (HP:0003220)2.18286048
75Absent radius (HP:0003974)2.17862839
76Increased IgE level (HP:0003212)2.17035501
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.16762302
78Cleft eyelid (HP:0000625)2.15341208
79Abnormality of reticulocytes (HP:0004312)2.14688808
80Myelodysplasia (HP:0002863)2.12367441
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11017236
82Rhabdomyosarcoma (HP:0002859)2.09243957
83Horseshoe kidney (HP:0000085)2.08661633
84Cellulitis (HP:0100658)2.07828815
85Abnormality of the Achilles tendon (HP:0005109)2.07415848
86Petechiae (HP:0000967)2.07364027
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.07248719
88Recurrent abscess formation (HP:0002722)2.07122902
89Pancytopenia (HP:0001876)2.06946313
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.06874893
91Recurrent viral infections (HP:0004429)2.06501192
92Hypoplasia of the radius (HP:0002984)2.05644660
93Nemaline bodies (HP:0003798)2.05514234
94Megaloblastic anemia (HP:0001889)2.04250835
95Small intestinal stenosis (HP:0012848)2.03632501
96Duodenal stenosis (HP:0100867)2.03632501
97Gastrointestinal inflammation (HP:0004386)2.02183994
98Mediastinal lymphadenopathy (HP:0100721)2.02033355
99Glossoptosis (HP:0000162)2.01804219
100Atresia of the external auditory canal (HP:0000413)2.00389722
101CNS hypomyelination (HP:0003429)2.00171713
102Abnormality of skeletal muscle fiber size (HP:0012084)1.99907411
103Absent forearm bone (HP:0003953)1.99691072
104Aplasia involving forearm bones (HP:0009822)1.99691072
105Abnormal number of incisors (HP:0011064)1.99676163
106Seborrheic dermatitis (HP:0001051)1.99334053
107Hepatocellular necrosis (HP:0001404)1.98476999
108Recurrent bacterial skin infections (HP:0005406)1.98394199
109Tracheoesophageal fistula (HP:0002575)1.97442479
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96807806
111Abnormality of the umbilical cord (HP:0010881)1.95654546
112Muscle fiber inclusion bodies (HP:0100299)1.95352849
113Fatigue (HP:0012378)1.94618531
114Basal cell carcinoma (HP:0002671)1.93585646
115Poor head control (HP:0002421)1.93197742
116Generalized amyotrophy (HP:0003700)1.93038883
117Squamous cell carcinoma (HP:0002860)1.92185072
118Abnormality of pyrimidine metabolism (HP:0004353)1.91019249
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90958493
120Increased CSF lactate (HP:0002490)1.90256160
121Hepatic necrosis (HP:0002605)1.89436613
122Triphalangeal thumb (HP:0001199)1.87100209
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86519332
124Cholelithiasis (HP:0001081)1.86509633
125Tongue fasciculations (HP:0001308)1.86412170
126Hepatosplenomegaly (HP:0001433)1.86258298
127Missing ribs (HP:0000921)1.85038962
128Premature skin wrinkling (HP:0100678)1.83887401
129Respiratory difficulties (HP:0002880)1.83272472
130Hemorrhage of the eye (HP:0011885)1.82384711
131Ulnar bowing (HP:0003031)1.82195665
132Sloping forehead (HP:0000340)1.80581721
133Bulbar palsy (HP:0001283)1.79488305
134Gastrointestinal stroma tumor (HP:0100723)1.78445032
135Abnormal lung lobation (HP:0002101)1.76690657
136Rectal prolapse (HP:0002035)1.76659272
137Easy fatigability (HP:0003388)1.76546602
138Postnatal microcephaly (HP:0005484)1.76462161
139Muscle stiffness (HP:0003552)1.76146467
140Abnormality of T cell physiology (HP:0011840)1.76030898
141Personality changes (HP:0000751)1.75979739
142Biconcave vertebral bodies (HP:0004586)1.75774259
143Thin bony cortex (HP:0002753)1.75741633
144Lymphoma (HP:0002665)1.75490895
145Aplasia/Hypoplasia of the thymus (HP:0010515)1.75462519
146Agammaglobulinemia (HP:0004432)1.75369680
147Stridor (HP:0010307)1.75268730
148IgM deficiency (HP:0002850)1.74819271
149Esophageal neoplasm (HP:0100751)1.74418473
150Neoplasm of head and neck (HP:0012288)1.74418473
151Exercise intolerance (HP:0003546)1.73533398
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72482780
153Abnormality of alanine metabolism (HP:0010916)1.72482780
154Hyperalaninemia (HP:0003348)1.72482780
155Increased variability in muscle fiber diameter (HP:0003557)1.72131470
156Inflammation of the large intestine (HP:0002037)1.72104758
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71628992
158Neoplasm of the colon (HP:0100273)1.71318313
159Reduced subcutaneous adipose tissue (HP:0003758)1.71290381
160Purpura (HP:0000979)1.70793569
161Truncus arteriosus (HP:0001660)1.70408248
162Mitochondrial inheritance (HP:0001427)1.70251651
163Microvesicular hepatic steatosis (HP:0001414)1.70192165
164Recurrent fungal infections (HP:0002841)1.69695007
165Muscle fibrillation (HP:0010546)1.69182113
166Slender long bone (HP:0003100)1.69153020
167Nausea (HP:0002018)1.69039926
168Hypertriglyceridemia (HP:0002155)1.68779183
169Reduced antithrombin III activity (HP:0001976)1.68663354
170Abnormal glycosylation (HP:0012345)1.68621642
171Deep palmar crease (HP:0006191)1.68343840
172Gastrointestinal infarctions (HP:0005244)1.66922767
173Reticulocytosis (HP:0001923)1.66499851
174Thoracic kyphosis (HP:0002942)1.65413207
175Increased cerebral lipofuscin (HP:0011813)1.64621058
176Gastrointestinal dysmotility (HP:0002579)1.64506828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.08230990
2WEE14.20395867
3TRIB33.87129705
4EIF2AK13.44353007
5SMG13.37348034
6CDC73.12603529
7STK163.04828240
8NME22.99452385
9PRPF4B2.58304130
10VRK22.45468423
11NEK22.43878010
12TSSK62.30330058
13TESK22.18687358
14BRSK22.13951141
15SRPK12.13574967
16NEK12.11423408
17EIF2AK32.11392185
18PLK42.00645871
19ACVR1B1.92725445
20TTK1.87320213
21PASK1.84942238
22TLK11.79847670
23PLK11.78496816
24ICK1.71997949
25EPHA21.69469219
26RPS6KB21.65097759
27TTN1.64627669
28VRK11.62700568
29CDK71.60201077
30DYRK31.59925380
31RPS6KA41.57042939
32SIK11.55982742
33PIM21.53560214
34ARAF1.50817034
35AURKB1.48477481
36BCKDK1.39922900
37TBK11.38880182
38SCYL21.35929379
39ATR1.35565959
40TESK11.35007272
41BRSK11.33940135
42KDR1.28746746
43AURKA1.27342607
44MAP3K131.26972965
45MAP3K81.25854920
46MKNK11.24959687
47MAP3K111.23989564
48PAK41.23699415
49CDK41.17479170
50PLK31.16066658
51ZAK1.15062082
52CHEK21.09460435
53MAP3K101.08371585
54EEF2K1.07968376
55MAP4K11.03106054
56TYK21.02868182
57IRAK40.99212393
58CCNB10.99210781
59STK100.97797183
60MAPKAPK30.96806170
61CHEK10.94354852
62RIPK40.90362751
63LRRK20.90256010
64FLT30.90001274
65TGFBR10.89662303
66MKNK20.88491815
67NME10.86285843
68PIM10.83908557
69STK40.82073613
70MAP2K30.81215063
71JAK30.81021286
72FGFR40.80035112
73PDK40.75478624
74PDK30.75478624
75CSK0.75170982
76PAK10.74119186
77BRAF0.74101514
78CSNK2A20.73158241
79MAP3K10.73047517
80PTK60.72748414
81PRKCI0.71724684
82ZAP700.70473592
83PDPK10.70043138
84CSNK2A10.69776512
85BMX0.68572976
86FES0.65851748
87CDK20.64555081
88PBK0.63742258
89CDK120.63718084
90MAP3K140.61335918
91TAOK20.60297598
92IRAK20.60272435
93PKN20.59218947
94BLK0.59104081
95PRKD20.58638510
96MOS0.58592049
97MAP3K30.57974218
98RPS6KL10.57970868
99RPS6KC10.57970868
100ATM0.56813899
101IRAK30.55626497
102KSR20.55085664
103DAPK30.53867433
104RPS6KA50.52134208
105MAPK120.49101131
106ILK0.48910224
107EIF2AK20.48293256
108HCK0.47757009
109IKBKE0.47291635
110CLK10.46168875
111CDK80.46023364
112MAP2K20.45895052
113ALK0.45640978
114TAOK10.45437073
115RPS6KA60.41462221
116SYK0.39043475
117CDK10.38432078
118AKT20.38397312
119EPHB10.37682778
120MARK20.37223299
121PDK10.37124288
122SIK30.36280781
123MARK30.36067292
124PDK20.34234864
125BTK0.33176020
126ERN10.32096513
127STK38L0.31657114
128ABL20.30684989
129CDK190.30534979
130MST40.30420236
131LIMK10.29783183
132CSNK1E0.28779389
133MTOR0.26688677
134CDK60.26393538
135GRK60.26077409
136DYRK20.25698387
137MAP2K60.25477846
138IKBKB0.23364374
139DAPK10.21952780
140MAPK110.21871651
141RPS6KA10.21712014

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69979603
2Proteasome_Homo sapiens_hsa030504.16773970
3Ribosome_Homo sapiens_hsa030104.15101114
4Mismatch repair_Homo sapiens_hsa034303.90078766
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65376837
6RNA polymerase_Homo sapiens_hsa030203.43086239
7Spliceosome_Homo sapiens_hsa030403.20524343
8* RNA transport_Homo sapiens_hsa030132.98069145
9Base excision repair_Homo sapiens_hsa034102.91945093
10Homologous recombination_Homo sapiens_hsa034402.66890645
11Pyrimidine metabolism_Homo sapiens_hsa002402.64838223
12Nucleotide excision repair_Homo sapiens_hsa034202.63073850
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52397540
14One carbon pool by folate_Homo sapiens_hsa006702.47866900
15Other glycan degradation_Homo sapiens_hsa005112.38294645
16Cell cycle_Homo sapiens_hsa041102.23766965
17Fanconi anemia pathway_Homo sapiens_hsa034601.75027312
18RNA degradation_Homo sapiens_hsa030181.68763914
19Basal transcription factors_Homo sapiens_hsa030221.58848931
20Non-homologous end-joining_Homo sapiens_hsa034501.57746549
21mRNA surveillance pathway_Homo sapiens_hsa030151.39854990
22p53 signaling pathway_Homo sapiens_hsa041151.39794942
23Purine metabolism_Homo sapiens_hsa002301.37029233
24Folate biosynthesis_Homo sapiens_hsa007901.31983213
25Sulfur relay system_Homo sapiens_hsa041221.29650181
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27446401
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.26875907
28B cell receptor signaling pathway_Homo sapiens_hsa046621.25595068
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20414159
30Epstein-Barr virus infection_Homo sapiens_hsa051691.19839129
31Pentose phosphate pathway_Homo sapiens_hsa000301.18983791
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17658985
33Chronic myeloid leukemia_Homo sapiens_hsa052201.16491157
34Biosynthesis of amino acids_Homo sapiens_hsa012301.10355995
35Protein export_Homo sapiens_hsa030601.10256071
36Vitamin B6 metabolism_Homo sapiens_hsa007501.05263307
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02961127
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.99074688
39Selenocompound metabolism_Homo sapiens_hsa004500.98704632
40T cell receptor signaling pathway_Homo sapiens_hsa046600.96873745
41Systemic lupus erythematosus_Homo sapiens_hsa053220.96870627
42Huntingtons disease_Homo sapiens_hsa050160.96801909
43Non-small cell lung cancer_Homo sapiens_hsa052230.96710648
44Parkinsons disease_Homo sapiens_hsa050120.96096293
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93416918
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.92685804
47Viral myocarditis_Homo sapiens_hsa054160.91929414
48Leishmaniasis_Homo sapiens_hsa051400.90847375
49Osteoclast differentiation_Homo sapiens_hsa043800.90546762
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.89362910
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88207036
52Antigen processing and presentation_Homo sapiens_hsa046120.88067313
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87760444
54Pancreatic cancer_Homo sapiens_hsa052120.86443716
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83827680
56VEGF signaling pathway_Homo sapiens_hsa043700.83390566
57Carbon metabolism_Homo sapiens_hsa012000.82877176
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81575925
59Glutathione metabolism_Homo sapiens_hsa004800.78154602
60Oxidative phosphorylation_Homo sapiens_hsa001900.77897457
61Lysosome_Homo sapiens_hsa041420.77297070
62Herpes simplex infection_Homo sapiens_hsa051680.76084814
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75906551
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74338374
65Viral carcinogenesis_Homo sapiens_hsa052030.74335619
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73668021
67Fructose and mannose metabolism_Homo sapiens_hsa000510.72887814
68Prion diseases_Homo sapiens_hsa050200.71744423
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68765624
70Legionellosis_Homo sapiens_hsa051340.66655229
71Allograft rejection_Homo sapiens_hsa053300.65699343
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64463492
73Autoimmune thyroid disease_Homo sapiens_hsa053200.62742952
74Oocyte meiosis_Homo sapiens_hsa041140.61858860
75Hematopoietic cell lineage_Homo sapiens_hsa046400.60497596
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59706459
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59126676
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58875091
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58306080
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58136046
81Salmonella infection_Homo sapiens_hsa051320.54208826
82HTLV-I infection_Homo sapiens_hsa051660.53761180
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53643752
84Thyroid cancer_Homo sapiens_hsa052160.53224407
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52528555
86Tuberculosis_Homo sapiens_hsa051520.51969739
87Toxoplasmosis_Homo sapiens_hsa051450.51756188
88mTOR signaling pathway_Homo sapiens_hsa041500.51005939
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49696017
90Galactose metabolism_Homo sapiens_hsa000520.49346727
91Insulin signaling pathway_Homo sapiens_hsa049100.48845857
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48196057
93N-Glycan biosynthesis_Homo sapiens_hsa005100.47173261
94TNF signaling pathway_Homo sapiens_hsa046680.47160803
95Graft-versus-host disease_Homo sapiens_hsa053320.46356914
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.45252669
97Hepatitis C_Homo sapiens_hsa051600.43777325
98Endocytosis_Homo sapiens_hsa041440.42539135
99Metabolic pathways_Homo sapiens_hsa011000.40013016
100Primary immunodeficiency_Homo sapiens_hsa053400.39747068
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.37514875
102Vibrio cholerae infection_Homo sapiens_hsa051100.35617194
103Apoptosis_Homo sapiens_hsa042100.33772459
104Arginine and proline metabolism_Homo sapiens_hsa003300.30266045
105Small cell lung cancer_Homo sapiens_hsa052220.28373418
106Alzheimers disease_Homo sapiens_hsa050100.27267031
107Measles_Homo sapiens_hsa051620.26142162
108Regulation of autophagy_Homo sapiens_hsa041400.25006845
109Shigellosis_Homo sapiens_hsa051310.24646181
110Pyruvate metabolism_Homo sapiens_hsa006200.22223010
111Bladder cancer_Homo sapiens_hsa052190.21029667
112Renin-angiotensin system_Homo sapiens_hsa046140.20821866
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19537823
114HIF-1 signaling pathway_Homo sapiens_hsa040660.18958939
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16995133
116Influenza A_Homo sapiens_hsa051640.16719842
117Alcoholism_Homo sapiens_hsa050340.15788864
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15359649
119MicroRNAs in cancer_Homo sapiens_hsa052060.14633544
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.13921241
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13209406
122Notch signaling pathway_Homo sapiens_hsa043300.13163663
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12196565
124Acute myeloid leukemia_Homo sapiens_hsa052210.12078669
125Hippo signaling pathway_Homo sapiens_hsa043900.11636057
126Hepatitis B_Homo sapiens_hsa051610.11323475
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.10873203
128Arachidonic acid metabolism_Homo sapiens_hsa005900.10676760
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09200070
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08833580
131TGF-beta signaling pathway_Homo sapiens_hsa043500.08600322
132Fat digestion and absorption_Homo sapiens_hsa049750.08515729
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.05840932
134Basal cell carcinoma_Homo sapiens_hsa052170.05391447
135Colorectal cancer_Homo sapiens_hsa052100.03960846
136Asthma_Homo sapiens_hsa053100.03456104

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