

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.46173286 |
| 2 | viral transcription (GO:0019083) | 5.82671792 |
| 3 | translational termination (GO:0006415) | 5.66971018 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 5.59994507 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.41148805 |
| 6 | translational elongation (GO:0006414) | 5.06170321 |
| 7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.99727166 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 4.88313938 |
| 9 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.87188130 |
| 10 | protein targeting to ER (GO:0045047) | 4.86612735 |
| 11 | * formation of translation preinitiation complex (GO:0001731) | 4.85597419 |
| 12 | ribosomal large subunit biogenesis (GO:0042273) | 4.76716785 |
| 13 | * translational initiation (GO:0006413) | 4.71046013 |
| 14 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.64125697 |
| 15 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.62487506 |
| 16 | protein localization to endoplasmic reticulum (GO:0070972) | 4.58984143 |
| 17 | viral life cycle (GO:0019058) | 4.44534236 |
| 18 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.43155611 |
| 19 | cellular protein complex disassembly (GO:0043624) | 4.40070005 |
| 20 | establishment of integrated proviral latency (GO:0075713) | 4.26368861 |
| 21 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.24678555 |
| 22 | ATP synthesis coupled proton transport (GO:0015986) | 4.20484803 |
| 23 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.20484803 |
| 24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.16533240 |
| 25 | DNA deamination (GO:0045006) | 4.16271907 |
| 26 | DNA strand elongation (GO:0022616) | 4.07095060 |
| 27 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.06973215 |
| 28 | DNA replication checkpoint (GO:0000076) | 4.02660048 |
| 29 | regulation of mitochondrial translation (GO:0070129) | 3.98847996 |
| 30 | * translation (GO:0006412) | 3.93672065 |
| 31 | ribosome biogenesis (GO:0042254) | 3.93311799 |
| 32 | DNA replication initiation (GO:0006270) | 3.93212933 |
| 33 | chaperone-mediated protein transport (GO:0072321) | 3.92966184 |
| 34 | protein complex disassembly (GO:0043241) | 3.90880020 |
| 35 | protein localization to kinetochore (GO:0034501) | 3.89490189 |
| 36 | nucleobase biosynthetic process (GO:0046112) | 3.88696248 |
| 37 | proteasome assembly (GO:0043248) | 3.79800634 |
| 38 | rRNA processing (GO:0006364) | 3.77371160 |
| 39 | macromolecular complex disassembly (GO:0032984) | 3.68494964 |
| 40 | positive regulation of ligase activity (GO:0051351) | 3.67126964 |
| 41 | rRNA metabolic process (GO:0016072) | 3.63108779 |
| 42 | tRNA aminoacylation for protein translation (GO:0006418) | 3.62867213 |
| 43 | purine nucleobase biosynthetic process (GO:0009113) | 3.62482334 |
| 44 | rRNA modification (GO:0000154) | 3.61352113 |
| 45 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.61080078 |
| 46 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.59184842 |
| 47 | telomere maintenance via recombination (GO:0000722) | 3.59039684 |
| 48 | protein targeting to mitochondrion (GO:0006626) | 3.58848427 |
| 49 | amino acid activation (GO:0043038) | 3.57734419 |
| 50 | tRNA aminoacylation (GO:0043039) | 3.57734419 |
| 51 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.55914582 |
| 52 | pseudouridine synthesis (GO:0001522) | 3.55879542 |
| 53 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.55131984 |
| 54 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.55131984 |
| 55 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.54238805 |
| 56 | establishment of viral latency (GO:0019043) | 3.54086771 |
| 57 | DNA unwinding involved in DNA replication (GO:0006268) | 3.52951224 |
| 58 | cellular component biogenesis (GO:0044085) | 3.48223826 |
| 59 | regulation of ligase activity (GO:0051340) | 3.43842451 |
| 60 | oxidative phosphorylation (GO:0006119) | 3.42975969 |
| 61 | mRNA catabolic process (GO:0006402) | 3.41453908 |
| 62 | cullin deneddylation (GO:0010388) | 3.40298537 |
| 63 | mitotic metaphase plate congression (GO:0007080) | 3.40157104 |
| 64 | protein deneddylation (GO:0000338) | 3.39631692 |
| 65 | CENP-A containing nucleosome assembly (GO:0034080) | 3.38284910 |
| 66 | mitotic recombination (GO:0006312) | 3.38160988 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.37007275 |
| 68 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.35345724 |
| 69 | regulation of translational fidelity (GO:0006450) | 3.35014970 |
| 70 | telomere maintenance via telomere lengthening (GO:0010833) | 3.33948574 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 3.33904771 |
| 72 | RNA catabolic process (GO:0006401) | 3.29562082 |
| 73 | establishment of protein localization to mitochondrion (GO:0072655) | 3.28854419 |
| 74 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.28771842 |
| 75 | respiratory electron transport chain (GO:0022904) | 3.28443747 |
| 76 | chromatin remodeling at centromere (GO:0031055) | 3.28344930 |
| 77 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.27964637 |
| 78 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.24380038 |
| 79 | negative regulation of ligase activity (GO:0051352) | 3.24380038 |
| 80 | termination of RNA polymerase III transcription (GO:0006386) | 3.23102196 |
| 81 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.23102196 |
| 82 | protein localization to mitochondrion (GO:0070585) | 3.22351289 |
| 83 | protein maturation by protein folding (GO:0022417) | 3.21597545 |
| 84 | IMP biosynthetic process (GO:0006188) | 3.20828063 |
| 85 | protein localization to chromosome, centromeric region (GO:0071459) | 3.20481727 |
| 86 | electron transport chain (GO:0022900) | 3.19706763 |
| 87 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.17275690 |
| 88 | ribosome assembly (GO:0042255) | 3.16669923 |
| 89 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.14141459 |
| 90 | protein targeting to membrane (GO:0006612) | 3.13692019 |
| 91 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.12085772 |
| 92 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.12085772 |
| 93 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.11998503 |
| 94 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.11394845 |
| 95 | mitotic nuclear envelope disassembly (GO:0007077) | 3.10789866 |
| 96 | IMP metabolic process (GO:0046040) | 3.09998023 |
| 97 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.09039266 |
| 98 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.09039266 |
| 99 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.09039266 |
| 100 | positive regulation of cell cycle arrest (GO:0071158) | 3.08876283 |
| 101 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.07997317 |
| 102 | rRNA methylation (GO:0031167) | 3.05425908 |
| 103 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.04956471 |
| 104 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.04956471 |
| 105 | protein complex biogenesis (GO:0070271) | 3.04897088 |
| 106 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.04833643 |
| 107 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.04688868 |
| 108 | negative regulation of protein ubiquitination (GO:0031397) | 3.03659816 |
| 109 | DNA replication-independent nucleosome organization (GO:0034724) | 3.03266370 |
| 110 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.03266370 |
| 111 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.03038391 |
| 112 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.01615251 |
| 113 | L-serine metabolic process (GO:0006563) | 3.01073783 |
| 114 | regulation of cellular amine metabolic process (GO:0033238) | 3.00871745 |
| 115 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.00682437 |
| 116 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.00275786 |
| 117 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.96488389 |
| 118 | maturation of 5.8S rRNA (GO:0000460) | 2.93106452 |
| 119 | mitotic sister chromatid segregation (GO:0000070) | 2.92075591 |
| 120 | 7-methylguanosine mRNA capping (GO:0006370) | 2.91853504 |
| 121 | transcription from RNA polymerase I promoter (GO:0006360) | 2.90718780 |
| 122 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.90607428 |
| 123 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.89838479 |
| 124 | cell cycle G1/S phase transition (GO:0044843) | 2.89838479 |
| 125 | viral mRNA export from host cell nucleus (GO:0046784) | 2.88828145 |
| 126 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.88441955 |
| 127 | metaphase plate congression (GO:0051310) | 2.88257358 |
| 128 | regulation of translation in response to stress (GO:0043555) | 2.87816565 |
| 129 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.87463605 |
| 130 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.87049565 |
| 131 | RNA capping (GO:0036260) | 2.86722762 |
| 132 | 7-methylguanosine RNA capping (GO:0009452) | 2.86722762 |
| 133 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.86205867 |
| 134 | spliceosomal complex assembly (GO:0000245) | 2.86147142 |
| 135 | ncRNA processing (GO:0034470) | 2.84683200 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.68744179 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.52652158 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.95982471 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.47645309 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.28618684 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.23717661 |
| 7 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.15175797 |
| 8 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.12355396 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.08698133 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.08268932 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01655121 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.01452498 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.93920391 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.92165785 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.80503728 |
| 16 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.79215258 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.57916324 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.52365702 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.43851862 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.35032244 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.31350791 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.26551463 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.18394670 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.13703045 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.08393967 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.06962641 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.03089252 |
| 28 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.94580109 |
| 29 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.94055803 |
| 30 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.88174664 |
| 31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.87323364 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.85549085 |
| 33 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84610686 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.82501610 |
| 35 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.80592186 |
| 36 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.73132295 |
| 37 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.72268931 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.68785440 |
| 39 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.66450059 |
| 40 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64230070 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.63441816 |
| 42 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.62162532 |
| 43 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.60912358 |
| 44 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.59557982 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58789724 |
| 46 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.58185033 |
| 47 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.51478407 |
| 48 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.50976108 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50693279 |
| 50 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.48840762 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.45516698 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42520352 |
| 53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.42273688 |
| 54 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.40914213 |
| 55 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.40070045 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.39329309 |
| 57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.39039312 |
| 58 | MYC_22102868_ChIP-Seq_BL_Human | 1.38729002 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.36029381 |
| 60 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.32828173 |
| 61 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.32759302 |
| 62 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.31163431 |
| 63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25258447 |
| 64 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25091433 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.24509512 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.23858603 |
| 67 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.20061113 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.19508136 |
| 69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19278143 |
| 70 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.19206934 |
| 71 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.18160655 |
| 72 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.18160655 |
| 73 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.18160655 |
| 74 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.17439882 |
| 75 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.17068850 |
| 76 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.15030966 |
| 77 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11892647 |
| 78 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.11300260 |
| 79 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.10762576 |
| 80 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.10583405 |
| 81 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.09046888 |
| 82 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.07591305 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.05255033 |
| 84 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.04930536 |
| 85 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03761494 |
| 86 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.02991108 |
| 87 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.02642460 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.01672131 |
| 89 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.01666394 |
| 90 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.00094728 |
| 91 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.99841789 |
| 92 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.98961429 |
| 93 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.97763156 |
| 94 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.97536171 |
| 95 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97062899 |
| 96 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.96641840 |
| 97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96619516 |
| 98 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.95855489 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94569813 |
| 100 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.94442808 |
| 101 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.93892539 |
| 102 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.93282286 |
| 103 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92434709 |
| 104 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.89101792 |
| 105 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.88073145 |
| 106 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.86232501 |
| 107 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.85664651 |
| 108 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.85569487 |
| 109 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.84669158 |
| 110 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.84598734 |
| 111 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.84491704 |
| 112 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84050426 |
| 113 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.83057671 |
| 114 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.82822948 |
| 115 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.80888902 |
| 116 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.80300261 |
| 117 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.80211281 |
| 118 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.78530640 |
| 119 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.78317580 |
| 120 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.77985671 |
| 121 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.77701684 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.12593836 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.54815438 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.90955435 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.76561261 |
| 5 | MP0008057_abnormal_DNA_replication | 3.71655012 |
| 6 | MP0003077_abnormal_cell_cycle | 3.66571367 |
| 7 | MP0008058_abnormal_DNA_repair | 3.00069127 |
| 8 | MP0002396_abnormal_hematopoietic_system | 2.55791984 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.54946031 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.53479341 |
| 11 | MP0003123_paternal_imprinting | 2.51088421 |
| 12 | MP0003786_premature_aging | 2.10721845 |
| 13 | MP0009697_abnormal_copulation | 2.06251692 |
| 14 | MP0009379_abnormal_foot_pigmentation | 2.05022298 |
| 15 | MP0005408_hypopigmentation | 2.04869792 |
| 16 | MP0000490_abnormal_crypts_of | 2.01325765 |
| 17 | MP0001730_embryonic_growth_arrest | 1.94583430 |
| 18 | MP0000350_abnormal_cell_proliferation | 1.92647282 |
| 19 | MP0010352_gastrointestinal_tract_polyps | 1.90375961 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.73557026 |
| 21 | MP0003806_abnormal_nucleotide_metabolis | 1.64879834 |
| 22 | MP0003718_maternal_effect | 1.61346522 |
| 23 | MP0005075_abnormal_melanosome_morpholog | 1.59084411 |
| 24 | MP0002132_abnormal_respiratory_system | 1.57180075 |
| 25 | MP0003186_abnormal_redox_activity | 1.55261040 |
| 26 | MP0006292_abnormal_olfactory_placode | 1.55239797 |
| 27 | MP0001672_abnormal_embryogenesis/_devel | 1.54749017 |
| 28 | MP0005380_embryogenesis_phenotype | 1.54749017 |
| 29 | MP0005171_absent_coat_pigmentation | 1.51844758 |
| 30 | MP0001661_extended_life_span | 1.50117787 |
| 31 | MP0001697_abnormal_embryo_size | 1.47802332 |
| 32 | MP0010030_abnormal_orbit_morphology | 1.46357853 |
| 33 | MP0004808_abnormal_hematopoietic_stem | 1.45287224 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.45076430 |
| 35 | MP0002877_abnormal_melanocyte_morpholog | 1.42733087 |
| 36 | MP0000313_abnormal_cell_death | 1.41140849 |
| 37 | MP0003984_embryonic_growth_retardation | 1.40273295 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.39991404 |
| 39 | MP0002080_prenatal_lethality | 1.39233523 |
| 40 | MP0002088_abnormal_embryonic_growth/wei | 1.37790215 |
| 41 | MP0003121_genomic_imprinting | 1.32563990 |
| 42 | MP0003315_abnormal_perineum_morphology | 1.30189615 |
| 43 | MP0002085_abnormal_embryonic_tissue | 1.22475704 |
| 44 | MP0008877_abnormal_DNA_methylation | 1.19807380 |
| 45 | MP0002086_abnormal_extraembryonic_tissu | 1.17546497 |
| 46 | MP0003567_abnormal_fetal_cardiomyocyte | 1.14639430 |
| 47 | MP0005397_hematopoietic_system_phenotyp | 1.14521099 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.14521099 |
| 49 | MP0006035_abnormal_mitochondrial_morpho | 1.14378890 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.11601845 |
| 51 | MP0004233_abnormal_muscle_weight | 1.11466684 |
| 52 | MP0004147_increased_porphyrin_level | 1.10074492 |
| 53 | MP0006036_abnormal_mitochondrial_physio | 1.10034009 |
| 54 | MP0003890_abnormal_embryonic-extraembry | 1.09469589 |
| 55 | MP0003950_abnormal_plasma_membrane | 1.08753121 |
| 56 | MP0002722_abnormal_immune_system | 1.08574804 |
| 57 | MP0002398_abnormal_bone_marrow | 1.08060173 |
| 58 | MP0002084_abnormal_developmental_patter | 1.08050586 |
| 59 | MP0004197_abnormal_fetal_growth/weight/ | 1.07739400 |
| 60 | MP0000689_abnormal_spleen_morphology | 1.05078492 |
| 61 | MP0006054_spinal_hemorrhage | 1.04197464 |
| 62 | MP0000358_abnormal_cell_content/ | 1.04166921 |
| 63 | MP0001293_anophthalmia | 1.03916643 |
| 64 | MP0000703_abnormal_thymus_morphology | 1.03196280 |
| 65 | MP0004264_abnormal_extraembryonic_tissu | 1.00661750 |
| 66 | MP0001853_heart_inflammation | 0.97770782 |
| 67 | MP0001764_abnormal_homeostasis | 0.97356132 |
| 68 | MP0001881_abnormal_mammary_gland | 0.96554048 |
| 69 | MP0003937_abnormal_limbs/digits/tail_de | 0.96467046 |
| 70 | MP0000858_altered_metastatic_potential | 0.96041069 |
| 71 | MP0008995_early_reproductive_senescence | 0.95301384 |
| 72 | MP0000749_muscle_degeneration | 0.94977992 |
| 73 | MP0010307_abnormal_tumor_latency | 0.94347572 |
| 74 | MP0002429_abnormal_blood_cell | 0.93119465 |
| 75 | MP0003011_delayed_dark_adaptation | 0.93065265 |
| 76 | MP0001529_abnormal_vocalization | 0.91534152 |
| 77 | MP0002938_white_spotting | 0.88220481 |
| 78 | MP0001727_abnormal_embryo_implantation | 0.86561732 |
| 79 | MP0002210_abnormal_sex_determination | 0.85341882 |
| 80 | MP0005257_abnormal_intraocular_pressure | 0.83845482 |
| 81 | MP0008438_abnormal_cutaneous_collagen | 0.83360333 |
| 82 | MP0000750_abnormal_muscle_regeneration | 0.82425702 |
| 83 | MP0004272_abnormal_basement_membrane | 0.81845552 |
| 84 | MP0003941_abnormal_skin_development | 0.81406131 |
| 85 | MP0001145_abnormal_male_reproductive | 0.81210539 |
| 86 | MP0002102_abnormal_ear_morphology | 0.81157266 |
| 87 | MP0005023_abnormal_wound_healing | 0.81152066 |
| 88 | MP0001929_abnormal_gametogenesis | 0.79037666 |
| 89 | MP0005332_abnormal_amino_acid | 0.78826008 |
| 90 | MP0001835_abnormal_antigen_presentation | 0.78334530 |
| 91 | MP0009672_abnormal_birth_weight | 0.78063408 |
| 92 | MP0005330_cardiomyopathy | 0.77854665 |
| 93 | MP0000678_abnormal_parathyroid_gland | 0.77584464 |
| 94 | MP0005379_endocrine/exocrine_gland_phen | 0.76724556 |
| 95 | MP0000716_abnormal_immune_system | 0.76612032 |
| 96 | MP0002160_abnormal_reproductive_system | 0.76485444 |
| 97 | MP0004133_heterotaxia | 0.74899270 |
| 98 | MP0002277_abnormal_respiratory_mucosa | 0.74882322 |
| 99 | MP0000762_abnormal_tongue_morphology | 0.74381969 |
| 100 | MP0002697_abnormal_eye_size | 0.71938939 |
| 101 | MP0002163_abnormal_gland_morphology | 0.71813847 |
| 102 | MP0002060_abnormal_skin_morphology | 0.71342368 |
| 103 | MP0000537_abnormal_urethra_morphology | 0.71276966 |
| 104 | MP0002405_respiratory_system_inflammati | 0.70400267 |
| 105 | MP0001800_abnormal_humoral_immune | 0.69538539 |
| 106 | MP0005384_cellular_phenotype | 0.68733282 |
| 107 | MP0002111_abnormal_tail_morphology | 0.68648666 |
| 108 | MP0006072_abnormal_retinal_apoptosis | 0.68312705 |
| 109 | MP0001346_abnormal_lacrimal_gland | 0.68178630 |
| 110 | MP0000049_abnormal_middle_ear | 0.67890863 |
| 111 | MP0005266_abnormal_metabolism | 0.67546239 |
| 112 | MP0003119_abnormal_digestive_system | 0.67293850 |
| 113 | MP0003136_yellow_coat_color | 0.67164954 |
| 114 | MP0000647_abnormal_sebaceous_gland | 0.67080603 |
| 115 | MP0005501_abnormal_skin_physiology | 0.67012451 |
| 116 | MP0001119_abnormal_female_reproductive | 0.66599433 |
| 117 | MP0005671_abnormal_response_to | 0.66418917 |
| 118 | MP0003122_maternal_imprinting | 0.66270197 |
| 119 | MP0004381_abnormal_hair_follicle | 0.65382263 |
| 120 | MP0003755_abnormal_palate_morphology | 0.65046778 |
| 121 | MP0005394_taste/olfaction_phenotype | 0.64567167 |
| 122 | MP0005499_abnormal_olfactory_system | 0.64567167 |
| 123 | MP0009785_altered_susceptibility_to | 0.64025925 |
| 124 | MP0001186_pigmentation_phenotype | 0.63642234 |
| 125 | MP0000372_irregular_coat_pigmentation | 0.63199035 |
| 126 | MP0002233_abnormal_nose_morphology | 0.63188126 |
| 127 | MP0005395_other_phenotype | 0.62930761 |
| 128 | MP0005389_reproductive_system_phenotype | 0.62707375 |
| 129 | MP0000653_abnormal_sex_gland | 0.62522974 |
| 130 | MP0000477_abnormal_intestine_morphology | 0.62132783 |
| 131 | MP0008789_abnormal_olfactory_epithelium | 0.62100063 |
| 132 | MP0002177_abnormal_outer_ear | 0.61734408 |
| 133 | MP0002420_abnormal_adaptive_immunity | 0.61713136 |
| 134 | MP0002282_abnormal_trachea_morphology | 0.61522141 |
| 135 | MP0001243_abnormal_dermal_layer | 0.60537090 |
| 136 | MP0003436_decreased_susceptibility_to | 0.60326912 |
| 137 | MP0001819_abnormal_immune_cell | 0.60289326 |
| 138 | MP0002090_abnormal_vision | 0.59517853 |
| 139 | MP0002095_abnormal_skin_pigmentation | 0.59189529 |
| 140 | MP0002932_abnormal_joint_morphology | 0.59025959 |
| 141 | MP0001286_abnormal_eye_development | 0.58193714 |
| 142 | MP0003705_abnormal_hypodermis_morpholog | 0.57158579 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 6.36018522 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.90487922 |
| 3 | Reticulocytopenia (HP:0001896) | 5.29281774 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.75411199 |
| 5 | Acute encephalopathy (HP:0006846) | 4.64224679 |
| 6 | Birth length less than 3rd percentile (HP:0003561) | 4.16353302 |
| 7 | Multiple enchondromatosis (HP:0005701) | 4.06434137 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.94092372 |
| 9 | Macrocytic anemia (HP:0001972) | 3.90263920 |
| 10 | Pallor (HP:0000980) | 3.71709045 |
| 11 | Aplastic anemia (HP:0001915) | 3.55451955 |
| 12 | Oral leukoplakia (HP:0002745) | 3.53417012 |
| 13 | Cerebral edema (HP:0002181) | 3.52272403 |
| 14 | Cholecystitis (HP:0001082) | 3.32025346 |
| 15 | Abnormal gallbladder physiology (HP:0012438) | 3.32025346 |
| 16 | Trismus (HP:0000211) | 3.31610735 |
| 17 | Rough bone trabeculation (HP:0100670) | 3.17340131 |
| 18 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.13564973 |
| 19 | Breast hypoplasia (HP:0003187) | 3.12974437 |
| 20 | Selective tooth agenesis (HP:0001592) | 3.11766409 |
| 21 | Lactic acidosis (HP:0003128) | 3.11192174 |
| 22 | Microretrognathia (HP:0000308) | 3.05090515 |
| 23 | Chromsome breakage (HP:0040012) | 2.96395427 |
| 24 | Exercise intolerance (HP:0003546) | 2.89649879 |
| 25 | Colon cancer (HP:0003003) | 2.87606177 |
| 26 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.85747283 |
| 27 | Renal Fanconi syndrome (HP:0001994) | 2.80243103 |
| 28 | Respiratory failure (HP:0002878) | 2.80043025 |
| 29 | Carpal bone hypoplasia (HP:0001498) | 2.76651139 |
| 30 | 11 pairs of ribs (HP:0000878) | 2.71814983 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.70618164 |
| 32 | Thrombocytosis (HP:0001894) | 2.66950630 |
| 33 | Glossoptosis (HP:0000162) | 2.65948274 |
| 34 | Cerebral hypomyelination (HP:0006808) | 2.64285287 |
| 35 | Type I transferrin isoform profile (HP:0003642) | 2.63908551 |
| 36 | Degeneration of anterior horn cells (HP:0002398) | 2.63613365 |
| 37 | Abnormality of the anterior horn cell (HP:0006802) | 2.63613365 |
| 38 | Patellar aplasia (HP:0006443) | 2.61218963 |
| 39 | Abnormality of methionine metabolism (HP:0010901) | 2.61113751 |
| 40 | Increased intramyocellular lipid droplets (HP:0012240) | 2.60760525 |
| 41 | Abnormal lung lobation (HP:0002101) | 2.59949814 |
| 42 | Meckel diverticulum (HP:0002245) | 2.58677185 |
| 43 | Abnormal protein glycosylation (HP:0012346) | 2.56424032 |
| 44 | Abnormal glycosylation (HP:0012345) | 2.56424032 |
| 45 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.56424032 |
| 46 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.56424032 |
| 47 | 3-Methylglutaconic aciduria (HP:0003535) | 2.55662048 |
| 48 | Abnormality of the preputium (HP:0100587) | 2.55041174 |
| 49 | Absent thumb (HP:0009777) | 2.53163008 |
| 50 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.47501908 |
| 51 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.47501908 |
| 52 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.46894473 |
| 53 | Secondary amenorrhea (HP:0000869) | 2.44743927 |
| 54 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.43364445 |
| 55 | Myelodysplasia (HP:0002863) | 2.42529961 |
| 56 | Abnormality of the ileum (HP:0001549) | 2.42349517 |
| 57 | Premature ovarian failure (HP:0008209) | 2.40259679 |
| 58 | Amniotic constriction ring (HP:0009775) | 2.39660984 |
| 59 | Abnormality of placental membranes (HP:0011409) | 2.39660984 |
| 60 | Rhabdomyosarcoma (HP:0002859) | 2.37971278 |
| 61 | Leukodystrophy (HP:0002415) | 2.34689713 |
| 62 | Sparse eyelashes (HP:0000653) | 2.34549540 |
| 63 | Abnormality of glycolysis (HP:0004366) | 2.31764704 |
| 64 | Increased serum pyruvate (HP:0003542) | 2.31764704 |
| 65 | Cleft eyelid (HP:0000625) | 2.31092908 |
| 66 | Premature graying of hair (HP:0002216) | 2.30478608 |
| 67 | Increased serum lactate (HP:0002151) | 2.26508640 |
| 68 | Abnormal trabecular bone morphology (HP:0100671) | 2.26501662 |
| 69 | Reduced antithrombin III activity (HP:0001976) | 2.21377556 |
| 70 | Increased hepatocellular lipid droplets (HP:0006565) | 2.21226188 |
| 71 | Bone marrow hypocellularity (HP:0005528) | 2.20700283 |
| 72 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.19023393 |
| 73 | Hepatocellular necrosis (HP:0001404) | 2.17433368 |
| 74 | Atresia of the external auditory canal (HP:0000413) | 2.16817229 |
| 75 | Medulloblastoma (HP:0002885) | 2.16638321 |
| 76 | Duodenal stenosis (HP:0100867) | 2.15085576 |
| 77 | Small intestinal stenosis (HP:0012848) | 2.15085576 |
| 78 | Pancytopenia (HP:0001876) | 2.14198263 |
| 79 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.14164644 |
| 80 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.12821706 |
| 81 | Triphalangeal thumb (HP:0001199) | 2.11892556 |
| 82 | Testicular atrophy (HP:0000029) | 2.09939332 |
| 83 | Increased CSF lactate (HP:0002490) | 2.09609666 |
| 84 | Increased muscle lipid content (HP:0009058) | 2.08731697 |
| 85 | Facial cleft (HP:0002006) | 2.08677002 |
| 86 | Progressive muscle weakness (HP:0003323) | 2.08106822 |
| 87 | CNS demyelination (HP:0007305) | 2.08000453 |
| 88 | Supernumerary spleens (HP:0009799) | 2.07249680 |
| 89 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.05505222 |
| 90 | Lethargy (HP:0001254) | 2.05260812 |
| 91 | Abnormality of chromosome stability (HP:0003220) | 2.04654940 |
| 92 | Ependymoma (HP:0002888) | 2.03912919 |
| 93 | Hypoplastic pelvis (HP:0008839) | 2.02433575 |
| 94 | Irregular epiphyses (HP:0010582) | 2.01474895 |
| 95 | Lipid accumulation in hepatocytes (HP:0006561) | 2.01164760 |
| 96 | Mitochondrial inheritance (HP:0001427) | 2.00990515 |
| 97 | Impulsivity (HP:0100710) | 1.99239441 |
| 98 | Abnormality of reticulocytes (HP:0004312) | 1.97551916 |
| 99 | Cellular immunodeficiency (HP:0005374) | 1.94864894 |
| 100 | Abnormal number of incisors (HP:0011064) | 1.94779678 |
| 101 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.94162439 |
| 102 | Single umbilical artery (HP:0001195) | 1.94162439 |
| 103 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.94162439 |
| 104 | Squamous cell carcinoma (HP:0002860) | 1.94063600 |
| 105 | Optic disc pallor (HP:0000543) | 1.93776554 |
| 106 | Hepatic necrosis (HP:0002605) | 1.92361091 |
| 107 | Emotional lability (HP:0000712) | 1.92348749 |
| 108 | Sloping forehead (HP:0000340) | 1.92023810 |
| 109 | Neoplasm of the pancreas (HP:0002894) | 1.91771415 |
| 110 | Absent radius (HP:0003974) | 1.91651971 |
| 111 | Tracheoesophageal fistula (HP:0002575) | 1.91608333 |
| 112 | Redundant skin (HP:0001582) | 1.90987078 |
| 113 | Poor head control (HP:0002421) | 1.90856550 |
| 114 | Agnosia (HP:0010524) | 1.89564386 |
| 115 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.87267539 |
| 116 | Respiratory difficulties (HP:0002880) | 1.85681501 |
| 117 | Abnormality of the labia minora (HP:0012880) | 1.85000230 |
| 118 | Entropion (HP:0000621) | 1.84807099 |
| 119 | Missing ribs (HP:0000921) | 1.84703870 |
| 120 | Exertional dyspnea (HP:0002875) | 1.84081728 |
| 121 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.83962406 |
| 122 | Hypoplasia of the radius (HP:0002984) | 1.83861432 |
| 123 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.83694570 |
| 124 | Abnormality of the umbilical cord (HP:0010881) | 1.82745443 |
| 125 | Ragged-red muscle fibers (HP:0003200) | 1.82583017 |
| 126 | CNS hypomyelination (HP:0003429) | 1.82261038 |
| 127 | Horseshoe kidney (HP:0000085) | 1.80669944 |
| 128 | Abnormality of the duodenum (HP:0002246) | 1.78417562 |
| 129 | Acute necrotizing encephalopathy (HP:0006965) | 1.78334324 |
| 130 | IgM deficiency (HP:0002850) | 1.77565201 |
| 131 | Muscle fiber atrophy (HP:0100295) | 1.77269384 |
| 132 | Cutaneous melanoma (HP:0012056) | 1.77133634 |
| 133 | Neoplasm of the adrenal gland (HP:0100631) | 1.75550570 |
| 134 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.75264554 |
| 135 | Absent forearm bone (HP:0003953) | 1.75208940 |
| 136 | Aplasia involving forearm bones (HP:0009822) | 1.75208940 |
| 137 | Asplenia (HP:0001746) | 1.75204798 |
| 138 | Depressed nasal ridge (HP:0000457) | 1.74845436 |
| 139 | Cholelithiasis (HP:0001081) | 1.73824859 |
| 140 | Hypokinesia (HP:0002375) | 1.73604668 |
| 141 | Embryonal renal neoplasm (HP:0011794) | 1.72561373 |
| 142 | Upper limb muscle weakness (HP:0003484) | 1.71837078 |
| 143 | Bilateral microphthalmos (HP:0007633) | 1.71540589 |
| 144 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.70564024 |
| 145 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.69973635 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.62543080 |
| 2 | BUB1 | 4.52642184 |
| 3 | NME2 | 3.93754070 |
| 4 | WEE1 | 3.66482655 |
| 5 | EIF2AK1 | 3.20559514 |
| 6 | CDC7 | 2.91352082 |
| 7 | STK16 | 2.72095141 |
| 8 | EIF2AK3 | 2.37635207 |
| 9 | SRPK1 | 2.36995226 |
| 10 | NEK2 | 2.03541627 |
| 11 | TSSK6 | 2.03489456 |
| 12 | TTK | 2.02354497 |
| 13 | TLK1 | 1.91616613 |
| 14 | PIM2 | 1.89340215 |
| 15 | RPS6KB2 | 1.85552270 |
| 16 | VRK1 | 1.83440250 |
| 17 | PLK1 | 1.82441459 |
| 18 | PDK2 | 1.79131055 |
| 19 | CDK7 | 1.71421854 |
| 20 | BRSK2 | 1.70847982 |
| 21 | PASK | 1.69589660 |
| 22 | TRIM28 | 1.64226372 |
| 23 | SMG1 | 1.63943107 |
| 24 | ACVR1B | 1.61145097 |
| 25 | AURKB | 1.55877643 |
| 26 | MKNK1 | 1.55156263 |
| 27 | NEK1 | 1.52976230 |
| 28 | CDK12 | 1.52402427 |
| 29 | DYRK3 | 1.52231007 |
| 30 | TGFBR1 | 1.49780122 |
| 31 | PLK4 | 1.48516186 |
| 32 | BCKDK | 1.45635054 |
| 33 | TAF1 | 1.40039298 |
| 34 | NUAK1 | 1.37779448 |
| 35 | MAP3K12 | 1.37297295 |
| 36 | TESK2 | 1.34841992 |
| 37 | ERN1 | 1.33124236 |
| 38 | RPS6KA4 | 1.30949480 |
| 39 | PAK4 | 1.28957668 |
| 40 | STK10 | 1.27132369 |
| 41 | ATR | 1.24614183 |
| 42 | EPHA2 | 1.22418816 |
| 43 | CHEK2 | 1.20543404 |
| 44 | AURKA | 1.20442615 |
| 45 | EEF2K | 1.20216933 |
| 46 | MKNK2 | 1.18952213 |
| 47 | NME1 | 1.14505784 |
| 48 | LIMK1 | 1.13681658 |
| 49 | IRAK3 | 1.13535339 |
| 50 | CDK4 | 1.07727809 |
| 51 | MAP3K8 | 1.03634808 |
| 52 | LRRK2 | 1.01801360 |
| 53 | PLK3 | 1.01264213 |
| 54 | MAP4K1 | 1.00497454 |
| 55 | GRK6 | 0.98359269 |
| 56 | MST4 | 0.97616602 |
| 57 | MAP2K3 | 0.96606470 |
| 58 | CDK8 | 0.96572497 |
| 59 | BRSK1 | 0.92314122 |
| 60 | CHEK1 | 0.92215205 |
| 61 | DAPK1 | 0.92033305 |
| 62 | PIM1 | 0.89251414 |
| 63 | EIF2AK2 | 0.87399185 |
| 64 | MAP3K11 | 0.85761224 |
| 65 | CSF1R | 0.84825894 |
| 66 | BRAF | 0.83279636 |
| 67 | FLT3 | 0.82916414 |
| 68 | ZAK | 0.80757895 |
| 69 | CSNK1G3 | 0.79866535 |
| 70 | MAP3K10 | 0.79594041 |
| 71 | MAP3K3 | 0.76552556 |
| 72 | CCNB1 | 0.76549737 |
| 73 | ILK | 0.75813385 |
| 74 | MST1R | 0.75388891 |
| 75 | ERBB4 | 0.74713112 |
| 76 | PAK1 | 0.74627090 |
| 77 | CSNK2A1 | 0.73385563 |
| 78 | STK4 | 0.72920427 |
| 79 | CSNK2A2 | 0.72840883 |
| 80 | KDR | 0.71685459 |
| 81 | CLK1 | 0.70378053 |
| 82 | PRKCI | 0.69296545 |
| 83 | MAPKAPK5 | 0.69282922 |
| 84 | ZAP70 | 0.68413427 |
| 85 | SCYL2 | 0.65539177 |
| 86 | ADRBK2 | 0.64029281 |
| 87 | TAOK2 | 0.63817644 |
| 88 | CSNK1G1 | 0.63417986 |
| 89 | MAP2K6 | 0.62910111 |
| 90 | MAPKAPK3 | 0.61750694 |
| 91 | ARAF | 0.57603894 |
| 92 | CDK2 | 0.57097750 |
| 93 | ATM | 0.55783987 |
| 94 | CSNK1A1L | 0.55783005 |
| 95 | MATK | 0.53901582 |
| 96 | PKN2 | 0.53822283 |
| 97 | PBK | 0.52849026 |
| 98 | BTK | 0.52188169 |
| 99 | PLK2 | 0.51931111 |
| 100 | STK38L | 0.51653420 |
| 101 | MOS | 0.51577067 |
| 102 | RPS6KA5 | 0.48021569 |
| 103 | IKBKB | 0.47701828 |
| 104 | DAPK3 | 0.46097512 |
| 105 | ABL2 | 0.44214638 |
| 106 | GRK1 | 0.42437359 |
| 107 | CSNK1G2 | 0.42048599 |
| 108 | DYRK2 | 0.41822875 |
| 109 | KIT | 0.40761021 |
| 110 | BCR | 0.40513586 |
| 111 | TESK1 | 0.39999717 |
| 112 | STK24 | 0.39071930 |
| 113 | PRKG2 | 0.37870755 |
| 114 | MUSK | 0.37661259 |
| 115 | SIK3 | 0.37579153 |
| 116 | MAP4K2 | 0.36647600 |
| 117 | AKT2 | 0.35715979 |
| 118 | CDK1 | 0.35601678 |
| 119 | PIK3CG | 0.35403621 |
| 120 | CDK19 | 0.35190571 |
| 121 | MYLK | 0.34324792 |
| 122 | TEC | 0.34172489 |
| 123 | BLK | 0.31645696 |
| 124 | CDK18 | 0.31171073 |
| 125 | LMTK2 | 0.30843319 |
| 126 | CSNK1E | 0.30453107 |
| 127 | ALK | 0.30345715 |
| 128 | CDK9 | 0.30155787 |
| 129 | FER | 0.29167159 |
| 130 | GRK5 | 0.28809309 |
| 131 | BMPR1B | 0.28440464 |
| 132 | CDK14 | 0.28282807 |
| 133 | CDK11A | 0.28244441 |
| 134 | FGFR1 | 0.26774990 |
| 135 | CDK15 | 0.25793472 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.27789679 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.37079631 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.96011502 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.72033560 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.57680127 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.56611032 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.94121158 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.77956572 |
| 9 | * RNA transport_Homo sapiens_hsa03013 | 2.73342432 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.63727002 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.60122048 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.56169096 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.31393100 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.17839142 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.09335278 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.78970715 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.74257790 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.72844703 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.71601082 |
| 20 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.61960040 |
| 21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.53177375 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.48986317 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.42053819 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.30890230 |
| 25 | Parkinsons disease_Homo sapiens_hsa05012 | 1.29639114 |
| 26 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.28418239 |
| 27 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.27630964 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.27009888 |
| 29 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.24689391 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.21341627 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.20438667 |
| 32 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.18398303 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13145484 |
| 34 | Huntingtons disease_Homo sapiens_hsa05016 | 1.12762801 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.04413570 |
| 36 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.02306131 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.01034116 |
| 38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.97167572 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 0.92346225 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.91420127 |
| 41 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.87346789 |
| 42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.87111811 |
| 43 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.85194817 |
| 44 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.81674810 |
| 45 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.81577431 |
| 46 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.80639792 |
| 47 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.80377052 |
| 48 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.77062891 |
| 49 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.74990369 |
| 50 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.73176830 |
| 51 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.71635939 |
| 52 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.69270392 |
| 53 | Galactose metabolism_Homo sapiens_hsa00052 | 0.65216343 |
| 54 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.64748897 |
| 55 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.64493520 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.63463901 |
| 57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63406854 |
| 58 | Legionellosis_Homo sapiens_hsa05134 | 0.63252645 |
| 59 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.61451175 |
| 60 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60460576 |
| 61 | Thyroid cancer_Homo sapiens_hsa05216 | 0.60334727 |
| 62 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.59274074 |
| 63 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.58524384 |
| 64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.58492594 |
| 65 | Alzheimers disease_Homo sapiens_hsa05010 | 0.57785277 |
| 66 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.56516611 |
| 67 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.53267372 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.50570884 |
| 69 | HTLV-I infection_Homo sapiens_hsa05166 | 0.50471973 |
| 70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.50035200 |
| 71 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.48696215 |
| 72 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.48675482 |
| 73 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.46562693 |
| 74 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.45527535 |
| 75 | Peroxisome_Homo sapiens_hsa04146 | 0.44564617 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.43192354 |
| 77 | Apoptosis_Homo sapiens_hsa04210 | 0.39955658 |
| 78 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.38497271 |
| 79 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.37357105 |
| 80 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36706404 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.36260688 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36084262 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.32651962 |
| 84 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.31198495 |
| 85 | Measles_Homo sapiens_hsa05162 | 0.31098408 |
| 86 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.30736818 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.28845915 |
| 88 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.27991665 |
| 89 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.27883238 |
| 90 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.27735687 |
| 91 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.27603673 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.26590716 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26104455 |
| 94 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.25779982 |
| 95 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.25604640 |
| 96 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.24952186 |
| 97 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.24750027 |
| 98 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.24543652 |
| 99 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.24386625 |
| 100 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.23113660 |
| 101 | Other glycan degradation_Homo sapiens_hsa00511 | 0.21540502 |
| 102 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19140638 |
| 103 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.19095192 |
| 104 | Influenza A_Homo sapiens_hsa05164 | 0.18810960 |
| 105 | Bladder cancer_Homo sapiens_hsa05219 | 0.17641242 |
| 106 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.16857573 |
| 107 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.16753947 |
| 108 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.16517199 |
| 109 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.16451928 |
| 110 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.16377929 |
| 111 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.16184068 |
| 112 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.15963598 |
| 113 | Shigellosis_Homo sapiens_hsa05131 | 0.15898063 |
| 114 | Allograft rejection_Homo sapiens_hsa05330 | 0.15272426 |
| 115 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.15039168 |
| 116 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.14827814 |
| 117 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.14742217 |
| 118 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.14662352 |
| 119 | Asthma_Homo sapiens_hsa05310 | 0.14181128 |
| 120 | Hepatitis B_Homo sapiens_hsa05161 | 0.14128613 |
| 121 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.13989840 |
| 122 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.13147204 |
| 123 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.12868907 |
| 124 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.12234189 |
| 125 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.10949856 |
| 126 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.08578520 |
| 127 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.07943986 |
| 128 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.07332101 |
| 129 | Lysine degradation_Homo sapiens_hsa00310 | 0.06770900 |
| 130 | Alcoholism_Homo sapiens_hsa05034 | 0.01927255 |

