EIF3J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.80326128
2maturation of SSU-rRNA (GO:0030490)5.31441435
3ribosomal large subunit biogenesis (GO:0042273)5.23735611
4ribosome assembly (GO:0042255)4.98262943
5* formation of translation preinitiation complex (GO:0001731)4.93926559
6ribonucleoprotein complex biogenesis (GO:0022613)4.90773563
7viral transcription (GO:0019083)4.68800267
8translational termination (GO:0006415)4.65217525
9nuclear pore complex assembly (GO:0051292)4.62834084
10ribosome biogenesis (GO:0042254)4.59639864
11ribosomal small subunit assembly (GO:0000028)4.33126100
12* translational initiation (GO:0006413)4.27391364
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.25313453
14cotranslational protein targeting to membrane (GO:0006613)4.21532979
15protein targeting to ER (GO:0045047)4.19993411
16nuclear pore organization (GO:0006999)4.17580656
17regulation of translational fidelity (GO:0006450)4.13058854
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.12975575
19rRNA processing (GO:0006364)4.08724024
20establishment of integrated proviral latency (GO:0075713)4.08662486
21IMP biosynthetic process (GO:0006188)4.08345239
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.08114926
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06677599
24IMP metabolic process (GO:0046040)4.05687462
25DNA unwinding involved in DNA replication (GO:0006268)3.99680817
26purine nucleobase biosynthetic process (GO:0009113)3.99187407
27translational elongation (GO:0006414)3.96192993
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.94108083
29proteasome assembly (GO:0043248)3.93793068
30protein localization to endoplasmic reticulum (GO:0070972)3.93223860
31rRNA metabolic process (GO:0016072)3.89867608
32nucleobase biosynthetic process (GO:0046112)3.89310552
33mitotic chromosome condensation (GO:0007076)3.87029594
34mitotic metaphase plate congression (GO:0007080)3.85676030
35CENP-A containing nucleosome assembly (GO:0034080)3.82925847
36DNA strand elongation involved in DNA replication (GO:0006271)3.79863804
37chromatin remodeling at centromere (GO:0031055)3.75889225
38* translation (GO:0006412)3.74675350
39cellular component biogenesis (GO:0044085)3.71858158
40DNA strand elongation (GO:0022616)3.69324596
41viral life cycle (GO:0019058)3.67353713
42DNA replication checkpoint (GO:0000076)3.64913406
43protein localization to kinetochore (GO:0034501)3.63732671
44folic acid-containing compound biosynthetic process (GO:0009396)3.63487964
45cellular protein complex disassembly (GO:0043624)3.59159095
46mitotic sister chromatid cohesion (GO:0007064)3.55722123
47protein localization to chromosome, centromeric region (GO:0071459)3.49723652
48telomere maintenance via semi-conservative replication (GO:0032201)3.43995632
49nucleobase-containing small molecule interconversion (GO:0015949)3.43767119
50pseudouridine synthesis (GO:0001522)3.43052860
51chaperone-mediated protein transport (GO:0072321)3.42590698
52regulation of mitochondrial translation (GO:0070129)3.42464740
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41595141
54pore complex assembly (GO:0046931)3.40371159
55mitotic sister chromatid segregation (GO:0000070)3.40312264
56spliceosomal snRNP assembly (GO:0000387)3.36368476
57histone exchange (GO:0043486)3.28893756
58negative regulation of RNA splicing (GO:0033119)3.27914453
59protein targeting to mitochondrion (GO:0006626)3.26583261
60rRNA modification (GO:0000154)3.25387972
61DNA replication-independent nucleosome assembly (GO:0006336)3.25239191
62DNA replication-independent nucleosome organization (GO:0034724)3.25239191
63termination of RNA polymerase II transcription (GO:0006369)3.25195119
64transcription from mitochondrial promoter (GO:0006390)3.24918534
65regulation of translational termination (GO:0006449)3.23035816
66protein complex disassembly (GO:0043241)3.21474599
67cellular protein complex localization (GO:0034629)3.20586499
68sister chromatid segregation (GO:0000819)3.20017746
69ATP synthesis coupled proton transport (GO:0015986)3.19172773
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19172773
71tRNA aminoacylation for protein translation (GO:0006418)3.19047869
72regulation of translational elongation (GO:0006448)3.19024878
73amino acid activation (GO:0043038)3.16735967
74tRNA aminoacylation (GO:0043039)3.16735967
75maturation of 5.8S rRNA (GO:0000460)3.16014305
76RNA splicing, via transesterification reactions (GO:0000375)3.14216922
77mRNA splicing, via spliceosome (GO:0000398)3.13994103
78RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.13994103
79metaphase plate congression (GO:0051310)3.12273770
80macromolecular complex disassembly (GO:0032984)3.12010309
81DNA replication initiation (GO:0006270)3.10882488
82protein localization to mitochondrion (GO:0070585)3.07866648
83nuclear-transcribed mRNA catabolic process (GO:0000956)3.07660857
84establishment of viral latency (GO:0019043)3.05859345
85negative regulation of mRNA processing (GO:0050686)3.04139832
86DNA-templated transcription, termination (GO:0006353)3.03704782
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00389280
88oxidative phosphorylation (GO:0006119)2.99263779
89telomere maintenance via recombination (GO:0000722)2.98691160
90transcription from RNA polymerase I promoter (GO:0006360)2.97314381
91establishment of protein localization to mitochondrion (GO:0072655)2.96352776
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.95299758
93termination of RNA polymerase III transcription (GO:0006386)2.95299758
94mRNA catabolic process (GO:0006402)2.95264718
95rRNA methylation (GO:0031167)2.94722149
96protein complex localization (GO:0031503)2.93997811
97mitotic nuclear envelope disassembly (GO:0007077)2.93879560
98DNA topological change (GO:0006265)2.93631264
99kinetochore organization (GO:0051383)2.92255147
100mitotic recombination (GO:0006312)2.92242703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36671090
2MYC_18555785_ChIP-Seq_MESCs_Mouse5.14140448
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01686890
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.00186713
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.42223266
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41399550
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39301509
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.38486397
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29682074
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.23635541
11MYC_19030024_ChIP-ChIP_MESCs_Mouse3.19495093
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.12338862
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10527815
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00843854
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.97285362
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92915961
17XRN2_22483619_ChIP-Seq_HELA_Human2.61176655
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58773109
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55867713
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48730093
21AR_21909140_ChIP-Seq_LNCAP_Human2.46780663
22* DCP1A_22483619_ChIP-Seq_HELA_Human2.46098163
23TTF2_22483619_ChIP-Seq_HELA_Human2.40058311
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.37929244
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24104084
26ELK1_19687146_ChIP-ChIP_HELA_Human2.24049049
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.23641530
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.18975823
29ZFX_18555785_ChIP-Seq_MESCs_Mouse2.12959955
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12671488
31E2F1_21310950_ChIP-Seq_MCF-7_Human2.11865497
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11548371
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01080489
34VDR_23849224_ChIP-Seq_CD4+_Human1.99593170
35FOXP3_21729870_ChIP-Seq_TREG_Human1.99284925
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98997435
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87644487
38GABP_19822575_ChIP-Seq_HepG2_Human1.83047136
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82512891
40ZNF263_19887448_ChIP-Seq_K562_Human1.80773292
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76217708
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62728481
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62726835
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60405678
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.58852576
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58755939
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57834490
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48381755
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46642724
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45741931
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45025483
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43891956
53* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42663234
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.39297932
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38940510
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36018276
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.33603867
58KDM5A_27292631_Chip-Seq_BREAST_Human1.33054023
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29582634
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28629263
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28490572
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27795599
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26684311
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26342909
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26291843
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25668626
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25429236
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19663288
69* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18905850
70MYC_22102868_ChIP-Seq_BL_Human1.16414931
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14755309
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09515529
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09450842
74CHD1_26751641_Chip-Seq_LNCaP_Human1.08581827
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07916213
76MYC_18940864_ChIP-ChIP_HL60_Human1.05808621
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.04086138
78TFEB_21752829_ChIP-Seq_HELA_Human1.03139015
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02411756
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01926848
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00449826
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99497072
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97736413
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95040244
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93324459
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.92533464
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89131484
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88994618
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87793790
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85261814
91CLOCK_20551151_ChIP-Seq_293T_Human0.81286340
92CIITA_25753668_ChIP-Seq_RAJI_Human0.79863984
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79783107
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79626433
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78282738
96* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77689806
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.76742407
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75688083
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75098357
100ELF5_23300383_ChIP-Seq_T47D_Human0.74927553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.64669768
2MP0003693_abnormal_embryo_hatching4.51305589
3MP0010094_abnormal_chromosome_stability4.11190717
4MP0008057_abnormal_DNA_replication3.97325737
5MP0003111_abnormal_nucleus_morphology3.79771619
6MP0008058_abnormal_DNA_repair3.50907239
7MP0002877_abnormal_melanocyte_morpholog3.35931403
8MP0003077_abnormal_cell_cycle3.20358681
9MP0008932_abnormal_embryonic_tissue2.92877287
10MP0008007_abnormal_cellular_replicative2.75102193
11MP0009379_abnormal_foot_pigmentation2.59411273
12MP0001730_embryonic_growth_arrest2.45505503
13MP0000350_abnormal_cell_proliferation2.28323142
14MP0003941_abnormal_skin_development2.24979429
15MP0004233_abnormal_muscle_weight2.14946350
16MP0003186_abnormal_redox_activity2.04489042
17MP0009697_abnormal_copulation2.03694990
18MP0006036_abnormal_mitochondrial_physio2.00681725
19MP0004185_abnormal_adipocyte_glucose1.84555708
20MP0003806_abnormal_nucleotide_metabolis1.78806148
21MP0001697_abnormal_embryo_size1.77610732
22MP0001672_abnormal_embryogenesis/_devel1.70917364
23MP0005380_embryogenesis_phenotype1.70917364
24MP0006035_abnormal_mitochondrial_morpho1.67951994
25MP0002080_prenatal_lethality1.60503084
26MP0003567_abnormal_fetal_cardiomyocyte1.59195061
27MP0003984_embryonic_growth_retardation1.56148953
28MP0002796_impaired_skin_barrier1.55381321
29MP0005451_abnormal_body_composition1.53564915
30MP0003718_maternal_effect1.52395762
31MP0002088_abnormal_embryonic_growth/wei1.51732669
32MP0010307_abnormal_tumor_latency1.50877616
33MP0003786_premature_aging1.50406105
34MP0005501_abnormal_skin_physiology1.48538761
35MP0009672_abnormal_birth_weight1.47633491
36MP0000313_abnormal_cell_death1.39906698
37MP0005076_abnormal_cell_differentiation1.38577095
38MP0003221_abnormal_cardiomyocyte_apopto1.37421645
39MP0002085_abnormal_embryonic_tissue1.31908811
40MP0003656_abnormal_erythrocyte_physiolo1.26462879
41MP0005408_hypopigmentation1.25912438
42MP0002084_abnormal_developmental_patter1.25799819
43MP0004145_abnormal_muscle_electrophysio1.25670300
44MP0002269_muscular_atrophy1.20707559
45MP0004197_abnormal_fetal_growth/weight/1.20500589
46MP0001881_abnormal_mammary_gland1.18740912
47MP0001727_abnormal_embryo_implantation1.17424834
48MP0002086_abnormal_extraembryonic_tissu1.16262762
49MP0003646_muscle_fatigue1.12425707
50MP0000358_abnormal_cell_content/1.10911203
51MP0003123_paternal_imprinting1.10614576
52MP0000747_muscle_weakness1.06958202
53MP0004087_abnormal_muscle_fiber1.05118667
54MP0001188_hyperpigmentation1.03394352
55MP0003315_abnormal_perineum_morphology1.02402953
56MP0005330_cardiomyopathy1.02218343
57MP0002210_abnormal_sex_determination1.01058534
58MP0010352_gastrointestinal_tract_polyps0.99842603
59MP0000759_abnormal_skeletal_muscle0.98204312
60MP0001293_anophthalmia0.97914350
61MP0002396_abnormal_hematopoietic_system0.96880515
62MP0000678_abnormal_parathyroid_gland0.96562359
63MP0000579_abnormal_nail_morphology0.96112912
64MP0000762_abnormal_tongue_morphology0.95483144
65MP0000749_muscle_degeneration0.92415316
66MP0003937_abnormal_limbs/digits/tail_de0.91060080
67MP0002160_abnormal_reproductive_system0.90015315
68MP0000490_abnormal_crypts_of0.89668870
69MP0004147_increased_porphyrin_level0.88533292
70MP0005666_abnormal_adipose_tissue0.88494769
71MP0000627_abnormal_mammary_gland0.85873792
72MP0010234_abnormal_vibrissa_follicle0.84985103
73MP0004808_abnormal_hematopoietic_stem0.84433670
74MP0002019_abnormal_tumor_incidence0.84258366
75MP0003950_abnormal_plasma_membrane0.83224975
76MP0003890_abnormal_embryonic-extraembry0.82835357
77MP0010630_abnormal_cardiac_muscle0.82497610
78MP0002697_abnormal_eye_size0.82469262
79MP0010030_abnormal_orbit_morphology0.79857083
80MP0004215_abnormal_myocardial_fiber0.78390538
81MP0004036_abnormal_muscle_relaxation0.77649690
82MP0005670_abnormal_white_adipose0.77250669
83MP0004084_abnormal_cardiac_muscle0.76954713
84MP0001145_abnormal_male_reproductive0.73278838
85MP0009703_decreased_birth_body0.71871975
86MP0001929_abnormal_gametogenesis0.71643722
87MP0001216_abnormal_epidermal_layer0.70663325
88MP0000372_irregular_coat_pigmentation0.70529319
89MP0009250_abnormal_appendicular_skeleto0.69428464
90MP0001286_abnormal_eye_development0.69101130
91MP0009333_abnormal_splenocyte_physiolog0.66590871
92MP0002111_abnormal_tail_morphology0.66329519
93MP0005384_cellular_phenotype0.66058482
94MP0001661_extended_life_span0.66051203
95MP0002060_abnormal_skin_morphology0.63346587
96MP0001853_heart_inflammation0.62476075
97MP0000653_abnormal_sex_gland0.60960980
98MP0002106_abnormal_muscle_physiology0.60420466
99MP0002938_white_spotting0.59708001
100MP0006292_abnormal_olfactory_placode0.59626035

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.11670337
2Macrocytic anemia (HP:0001972)4.06984618
3Muscle fiber inclusion bodies (HP:0100299)3.97890255
4Increased hepatocellular lipid droplets (HP:0006565)3.94256483
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.92395479
6Acute necrotizing encephalopathy (HP:0006965)3.77023101
7Abnormality of cells of the erythroid lineage (HP:0012130)3.71407743
8Increased serum pyruvate (HP:0003542)3.60063130
9Multiple enchondromatosis (HP:0005701)3.56587582
10Progressive muscle weakness (HP:0003323)3.52386449
11Abnormal mitochondria in muscle tissue (HP:0008316)3.47684952
12Abnormality of glycolysis (HP:0004366)3.45277600
13Birth length less than 3rd percentile (HP:0003561)3.38307413
14Acute encephalopathy (HP:0006846)3.35556823
15Chromsome breakage (HP:0040012)3.32856789
16Lipid accumulation in hepatocytes (HP:0006561)3.30747097
17Reticulocytopenia (HP:0001896)3.29101482
18Abnormal number of erythroid precursors (HP:0012131)3.13283269
19Microvesicular hepatic steatosis (HP:0001414)3.00105070
20Pallor (HP:0000980)2.96215276
21Increased CSF lactate (HP:0002490)2.93522616
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89764201
23Progressive macrocephaly (HP:0004481)2.84740363
24Cerebral edema (HP:0002181)2.82371245
25Oral leukoplakia (HP:0002745)2.79717042
26Calcaneovalgus deformity (HP:0001848)2.72524698
27Hyperalaninemia (HP:0003348)2.72018277
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72018277
29Abnormality of alanine metabolism (HP:0010916)2.72018277
30Mitochondrial inheritance (HP:0001427)2.69265165
31Increased intramyocellular lipid droplets (HP:0012240)2.67231873
32Aplastic anemia (HP:0001915)2.64466939
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62415962
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62415962
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61043874
36Deformed tarsal bones (HP:0008119)2.59272831
37Exercise-induced muscle cramps (HP:0003710)2.56838377
38Renal Fanconi syndrome (HP:0001994)2.51855943
39Exercise intolerance (HP:0003546)2.51292789
40Volvulus (HP:0002580)2.48627573
41Megaloblastic anemia (HP:0001889)2.48057901
42Increased serum lactate (HP:0002151)2.41281546
43Respiratory difficulties (HP:0002880)2.40869827
44Trismus (HP:0000211)2.35518045
45Shoulder girdle muscle weakness (HP:0003547)2.28766459
46Sparse eyelashes (HP:0000653)2.26263015
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25559491
48Increased nuchal translucency (HP:0010880)2.23836108
49Gout (HP:0001997)2.17049184
50Progressive external ophthalmoplegia (HP:0000590)2.14515981
51Cortical dysplasia (HP:0002539)2.13619666
52Cerebral hypomyelination (HP:0006808)2.07876039
53Lactic acidosis (HP:0003128)2.07582881
54Degeneration of anterior horn cells (HP:0002398)2.05922716
55Abnormality of the anterior horn cell (HP:0006802)2.05922716
56Testicular atrophy (HP:0000029)2.05748107
57Pancytopenia (HP:0001876)2.05369017
58Type 1 muscle fiber predominance (HP:0003803)2.05007572
59Abnormality of methionine metabolism (HP:0010901)2.03426193
60Increased muscle lipid content (HP:0009058)2.03213886
61Leukodystrophy (HP:0002415)2.01834378
62Abnormality of the preputium (HP:0100587)2.00762174
63Distal arthrogryposis (HP:0005684)1.98281903
64Reduced antithrombin III activity (HP:0001976)1.97648305
65Abnormality of placental membranes (HP:0011409)1.97583109
66Amniotic constriction ring (HP:0009775)1.97583109
67Paralysis (HP:0003470)1.95040716
68Rough bone trabeculation (HP:0100670)1.94615413
69Overlapping toe (HP:0001845)1.92528618
70Horseshoe kidney (HP:0000085)1.92148823
71Myelodysplasia (HP:0002863)1.92039511
72Ragged-red muscle fibers (HP:0003200)1.89210537
73Abnormality of chromosome stability (HP:0003220)1.89191538
74Premature ovarian failure (HP:0008209)1.88645050
75Pelvic girdle muscle weakness (HP:0003749)1.88486493
76Abnormality of serum amino acid levels (HP:0003112)1.88071852
77Exertional dyspnea (HP:0002875)1.87836503
78Secondary amenorrhea (HP:0000869)1.87303129
79Type I transferrin isoform profile (HP:0003642)1.85610321
80Stenosis of the external auditory canal (HP:0000402)1.85580763
81Hepatocellular necrosis (HP:0001404)1.83801699
82Abnormality of the pons (HP:0007361)1.82688433
83Abnormality of reticulocytes (HP:0004312)1.80976842
84Hepatic necrosis (HP:0002605)1.80855086
85Selective tooth agenesis (HP:0001592)1.80610571
86Rhabdomyolysis (HP:0003201)1.78940608
87Myopathic facies (HP:0002058)1.77846325
88Abnormal lung lobation (HP:0002101)1.77049442
89Short middle phalanx of the 5th finger (HP:0004220)1.76660138
90Acute myeloid leukemia (HP:0004808)1.75767403
91Meckel diverticulum (HP:0002245)1.75386829
92Exercise-induced myalgia (HP:0003738)1.74539916
93Squamous cell carcinoma (HP:0002860)1.70795248
94Glossoptosis (HP:0000162)1.69240088
95Urethral obstruction (HP:0000796)1.68957463
96Myoglobinuria (HP:0002913)1.68744579
97Deviation of the thumb (HP:0009603)1.66668533
98Dysphonia (HP:0001618)1.66596538
99Respiratory failure (HP:0002878)1.66186068
1003-Methylglutaconic aciduria (HP:0003535)1.65176891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.83255721
2EIF2AK13.72342486
3TSSK63.69454876
4BUB13.60505374
5NEK13.36914054
6SRPK13.32893218
7PBK2.90511857
8NME22.86458494
9TTK2.83627743
10WEE12.17997531
11MST42.08561802
12EIF2AK32.03538821
13MKNK12.00356832
14STK161.98023842
15VRK21.91690686
16PDK21.87831193
17PLK31.76825456
18RPS6KB21.70863262
19TAF11.70409974
20PNCK1.69462471
21LATS21.69311828
22BRSK21.66462446
23PLK41.56253333
24IRAK31.50902664
25NME11.50423205
26MKNK21.48304172
27CDK121.46263602
28PLK11.40358075
29OBSCN1.37891134
30SCYL21.37725858
31ALK1.26619776
32AURKB1.25743539
33CHEK21.17084415
34CHEK11.14724181
35CLK11.08964938
36ATR1.02969646
37CDK41.02530142
38CDK70.99286465
39PASK0.99023252
40VRK10.95391127
41RPS6KA40.94632205
42BRSK10.93010947
43EIF2AK20.92394637
44CSNK1E0.92389359
45MAP3K80.91096064
46DMPK0.87439059
47CSNK2A20.87352065
48STK240.87162822
49MAP3K100.87038362
50LATS10.86807575
51NEK20.85327284
52ARAF0.85177759
53ERBB40.82290667
54STK40.81043717
55AURKA0.80256856
56BRAF0.78582675
57CDK80.75902799
58STK30.73776380
59ATM0.73130119
60BMPR20.72334164
61WNK40.71778717
62CSNK2A10.67109122
63SMG10.66351390
64PAK40.64623724
65ILK0.63645401
66CDK20.63498487
67CDK10.63494305
68TTN0.63491570
69CCNB10.63185266
70TAOK20.62740679
71MAP3K90.60704965
72PAK20.60513347
73TESK10.60395101
74DYRK30.59985156
75AKT20.59750051
76TRIM280.58094382
77MOS0.57905647
78PHKG20.56938816
79PHKG10.56938816
80MAP3K140.56421170
81ABL20.52846907
82ERBB30.46595016
83MAP3K120.46179171
84CDK11A0.45365575
85RAF10.44139655
86CDK180.38613871
87FGFR10.38428671
88PRKDC0.38034265
89CDK140.37844118
90PIK3CG0.37704670
91KSR10.37630533
92CDK60.37615882
93BCR0.36429189
94CDK150.36270060
95PIM20.36266789
96WNK10.35768969
97EEF2K0.35559134
98STK390.33902691
99STK100.33193720
100CDK30.31329712

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.59447302
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98517228
3DNA replication_Homo sapiens_hsa030303.83966233
4Proteasome_Homo sapiens_hsa030503.33344943
5Spliceosome_Homo sapiens_hsa030403.30117742
6Mismatch repair_Homo sapiens_hsa034303.23920350
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05769296
8Protein export_Homo sapiens_hsa030602.73201314
9* RNA transport_Homo sapiens_hsa030132.72424842
10RNA polymerase_Homo sapiens_hsa030202.63839873
11Nucleotide excision repair_Homo sapiens_hsa034202.57427219
12One carbon pool by folate_Homo sapiens_hsa006702.54634996
13Basal transcription factors_Homo sapiens_hsa030222.15628111
14Oxidative phosphorylation_Homo sapiens_hsa001902.15528068
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14020262
16Parkinsons disease_Homo sapiens_hsa050122.13769719
17Base excision repair_Homo sapiens_hsa034102.12834726
18Homologous recombination_Homo sapiens_hsa034402.10017092
19Cell cycle_Homo sapiens_hsa041102.05434612
20Pyrimidine metabolism_Homo sapiens_hsa002401.83623953
21mRNA surveillance pathway_Homo sapiens_hsa030151.81584801
22Non-homologous end-joining_Homo sapiens_hsa034501.79056530
23RNA degradation_Homo sapiens_hsa030181.73958415
24Pyruvate metabolism_Homo sapiens_hsa006201.67247075
25Huntingtons disease_Homo sapiens_hsa050161.58004482
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.47315223
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43514595
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36432961
29Alzheimers disease_Homo sapiens_hsa050101.29323110
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26126487
31Folate biosynthesis_Homo sapiens_hsa007901.25836613
32Carbon metabolism_Homo sapiens_hsa012001.25113147
33Biosynthesis of amino acids_Homo sapiens_hsa012301.24599768
34Fanconi anemia pathway_Homo sapiens_hsa034601.21872648
35Purine metabolism_Homo sapiens_hsa002301.17074517
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15652451
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09296641
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07587243
39Vitamin B6 metabolism_Homo sapiens_hsa007500.99801382
40Cardiac muscle contraction_Homo sapiens_hsa042600.96428505
41Sulfur relay system_Homo sapiens_hsa041220.96387744
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95547175
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88467548
44Selenocompound metabolism_Homo sapiens_hsa004500.87211621
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85264353
46Propanoate metabolism_Homo sapiens_hsa006400.79286525
47Oocyte meiosis_Homo sapiens_hsa041140.74371203
48Thyroid cancer_Homo sapiens_hsa052160.74019568
49Epstein-Barr virus infection_Homo sapiens_hsa051690.73929598
50Pentose phosphate pathway_Homo sapiens_hsa000300.72817020
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68769197
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67780145
53p53 signaling pathway_Homo sapiens_hsa041150.66158919
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66144552
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64304964
56Arginine and proline metabolism_Homo sapiens_hsa003300.58532180
57Steroid biosynthesis_Homo sapiens_hsa001000.58447915
58Bladder cancer_Homo sapiens_hsa052190.57469803
59Glutathione metabolism_Homo sapiens_hsa004800.49644660
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43422783
61Metabolic pathways_Homo sapiens_hsa011000.42486776
62Fructose and mannose metabolism_Homo sapiens_hsa000510.38983075
63Fatty acid elongation_Homo sapiens_hsa000620.35591760
64Sulfur metabolism_Homo sapiens_hsa009200.35455818
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.34000307
66Chronic myeloid leukemia_Homo sapiens_hsa052200.33016779
67Viral carcinogenesis_Homo sapiens_hsa052030.32677403
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32120027
69Arginine biosynthesis_Homo sapiens_hsa002200.31561194
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.30816573
71Small cell lung cancer_Homo sapiens_hsa052220.29259335
72N-Glycan biosynthesis_Homo sapiens_hsa005100.27081659
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26435407
74Shigellosis_Homo sapiens_hsa051310.23280730
75Prion diseases_Homo sapiens_hsa050200.22093743
76HTLV-I infection_Homo sapiens_hsa051660.21745985
77MicroRNAs in cancer_Homo sapiens_hsa052060.19562452
78TGF-beta signaling pathway_Homo sapiens_hsa043500.19468956
79Pancreatic cancer_Homo sapiens_hsa052120.18274587
80Galactose metabolism_Homo sapiens_hsa000520.17991293
81Legionellosis_Homo sapiens_hsa051340.15969719
82Renal cell carcinoma_Homo sapiens_hsa052110.15243511
83Wnt signaling pathway_Homo sapiens_hsa043100.14415310
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13644704
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13413597
86Circadian rhythm_Homo sapiens_hsa047100.12955070
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12179737
88Fatty acid metabolism_Homo sapiens_hsa012120.12148199
89Hippo signaling pathway_Homo sapiens_hsa043900.11660356
90Melanoma_Homo sapiens_hsa052180.09202621
91Tight junction_Homo sapiens_hsa045300.08129317
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07241460
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.07068811
94Adherens junction_Homo sapiens_hsa045200.06387085
95Insulin signaling pathway_Homo sapiens_hsa049100.06253874
96Herpes simplex infection_Homo sapiens_hsa051680.05788256
97HIF-1 signaling pathway_Homo sapiens_hsa040660.05247489
98Prostate cancer_Homo sapiens_hsa052150.04879096
99Fatty acid biosynthesis_Homo sapiens_hsa000610.04587418
100Glucagon signaling pathway_Homo sapiens_hsa049220.04394608

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