EIF3KP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone secretion (GO:0030252)9.90332464
2positive regulation of growth hormone secretion (GO:0060124)9.83844255
3glomerular visceral epithelial cell development (GO:0072015)7.64478754
4glomerular epithelial cell development (GO:0072310)6.72215493
5regulation of growth hormone secretion (GO:0060123)6.64979996
6positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)6.06535260
7coenzyme catabolic process (GO:0009109)5.75198870
8regulation of female receptivity (GO:0045924)5.59893751
9phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.42973904
10determination of adult lifespan (GO:0008340)5.41749684
11adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.38586043
12NIK/NF-kappaB signaling (GO:0038061)5.29844560
13regulation of metalloenzyme activity (GO:0048552)5.28616809
14nucleoside diphosphate catabolic process (GO:0009134)4.96611914
15water-soluble vitamin biosynthetic process (GO:0042364)4.93334854
16negative regulation of telomere maintenance (GO:0032205)4.91266249
17natural killer cell differentiation (GO:0001779)4.81334085
18cornea development in camera-type eye (GO:0061303)4.81042343
19female mating behavior (GO:0060180)4.64681925
20cofactor catabolic process (GO:0051187)4.64275614
21transmission of nerve impulse (GO:0019226)4.53319257
22regulation of G0 to G1 transition (GO:0070316)4.46714056
23neuron fate determination (GO:0048664)4.39482779
24synaptic transmission, dopaminergic (GO:0001963)4.27934654
25activation of adenylate cyclase activity (GO:0007190)4.20220631
26coenzyme A metabolic process (GO:0015936)4.12511989
27regulation of protein heterodimerization activity (GO:0043497)4.11355807
28organelle disassembly (GO:1903008)4.02455316
29deoxyribose phosphate catabolic process (GO:0046386)4.02210787
30nucleotide transmembrane transport (GO:1901679)3.97642793
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.93987317
32deoxyribonucleotide catabolic process (GO:0009264)3.92639453
33purine deoxyribonucleotide catabolic process (GO:0009155)3.90509008
34regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.88133701
35protein localization to cilium (GO:0061512)3.69944255
36adaptation of signaling pathway (GO:0023058)3.63397298
37cAMP-mediated signaling (GO:0019933)3.57616718
38positive regulation of adenylate cyclase activity (GO:0045762)3.57464471
39purine ribonucleotide transport (GO:0015868)3.54970771
40regulation of RIG-I signaling pathway (GO:0039535)3.52790544
41positive regulation of prostaglandin secretion (GO:0032308)3.49864169
42negative regulation of Ras GTPase activity (GO:0034261)3.44043336
43regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.41822080
44adenine nucleotide transport (GO:0051503)3.38671400
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35355411
46response to pheromone (GO:0019236)3.32101728
47positive regulation of lyase activity (GO:0051349)3.23123774
48otic vesicle formation (GO:0030916)3.15726956
49ribonucleoside bisphosphate metabolic process (GO:0033875)3.11452544
50nucleoside bisphosphate metabolic process (GO:0033865)3.11452544
51purine nucleoside bisphosphate metabolic process (GO:0034032)3.11452544
52oxidative phosphorylation (GO:0006119)3.10403579
53adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.07700429
54anterograde synaptic vesicle transport (GO:0048490)3.06538493
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05045309
56response to redox state (GO:0051775)3.04838195
57sulfate transmembrane transport (GO:1902358)3.02463336
58actin nucleation (GO:0045010)3.01936719
59purine deoxyribonucleotide metabolic process (GO:0009151)3.01099866
60ATP synthesis coupled proton transport (GO:0015986)3.00993218
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00993218
62ganglioside metabolic process (GO:0001573)3.00732222
63pyrimidine-containing compound transmembrane transport (GO:0072531)2.95959571
64positive regulation of multicellular organism growth (GO:0040018)2.90749888
65positive regulation of cyclase activity (GO:0031281)2.89744333
66acetyl-CoA metabolic process (GO:0006084)2.86232255
67negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.85290179
68regulation of prostaglandin secretion (GO:0032306)2.84669881
69regulation of synapse structural plasticity (GO:0051823)2.84377082
70ribonucleoside diphosphate metabolic process (GO:0009185)2.83993473
71synaptic transmission, cholinergic (GO:0007271)2.83463517
72keratinocyte development (GO:0003334)2.83275924
73negative regulation of mast cell activation (GO:0033004)2.83262868
74regulation of telomere maintenance via telomerase (GO:0032210)2.82866124
75regulation of ruffle assembly (GO:1900027)2.82052625
76chaperone-mediated protein transport (GO:0072321)2.81664143
77limb bud formation (GO:0060174)2.81080728
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80594120
79sulfate transport (GO:0008272)2.80531292
80aerobic respiration (GO:0009060)2.79738041
81protein localization to kinetochore (GO:0034501)2.79391298
82negative regulation of oxidoreductase activity (GO:0051354)2.76410451
83nucleoside diphosphate metabolic process (GO:0009132)2.76049615
84respiratory electron transport chain (GO:0022904)2.74174942
85deoxyribose phosphate metabolic process (GO:0019692)2.74128690
86electron transport chain (GO:0022900)2.73796663
87autophagic vacuole fusion (GO:0000046)2.73148506
88maturation of SSU-rRNA (GO:0030490)2.72025445
89regulation of protein targeting to membrane (GO:0090313)2.70819860
90positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70732970
91positive regulation of p38MAPK cascade (GO:1900745)2.69647650
92hydrogen ion transmembrane transport (GO:1902600)2.69407950
93DNA integration (GO:0015074)2.67639181
94deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.67047493
95ribonucleoprotein complex disassembly (GO:0032988)2.67032905
96nucleotide transport (GO:0006862)2.66570701
97metallo-sulfur cluster assembly (GO:0031163)2.66242801
98iron-sulfur cluster assembly (GO:0016226)2.66242801
99xenobiotic catabolic process (GO:0042178)2.65929435
100purine nucleoside diphosphate metabolic process (GO:0009135)2.65740582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65484795
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34391121
3EZH2_22144423_ChIP-Seq_EOC_Human3.24077304
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.08999659
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.04987585
6TAF15_26573619_Chip-Seq_HEK293_Human2.69212478
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64828595
8VDR_22108803_ChIP-Seq_LS180_Human2.47562528
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30467575
10ER_23166858_ChIP-Seq_MCF-7_Human1.96832400
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96123908
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92170904
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90984420
14PHF8_20622853_ChIP-Seq_HELA_Human1.84794131
15RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84068464
16P53_22127205_ChIP-Seq_FIBROBLAST_Human1.81535383
17P300_19829295_ChIP-Seq_ESCs_Human1.79579176
18REST_21632747_ChIP-Seq_MESCs_Mouse1.76367747
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71495283
20RBPJ_21746931_ChIP-Seq_IB4_Human1.70357450
21DROSHA_22980978_ChIP-Seq_HELA_Human1.68345665
22TP53_22573176_ChIP-Seq_HFKS_Human1.63064950
23ETV1_20927104_ChIP-Seq_GIST48_Human1.60416979
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59665314
25NFYB_21822215_ChIP-Seq_K562_Human1.59022665
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.56809351
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53115041
28NFYA_21822215_ChIP-Seq_K562_Human1.51784426
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51369080
30CBP_20019798_ChIP-Seq_JUKART_Human1.51369080
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.48856427
32TBL1_22424771_ChIP-Seq_293T_Human1.48654490
33CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47976900
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.46865189
35PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.46209634
36ERA_21632823_ChIP-Seq_H3396_Human1.45406700
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44313825
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43583065
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43061852
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.41632767
41ZNF274_21170338_ChIP-Seq_K562_Hela1.40345332
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.38651851
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.38277408
44FUS_26573619_Chip-Seq_HEK293_Human1.36018868
45SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.35899570
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35678890
47EWS_26573619_Chip-Seq_HEK293_Human1.35186795
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.34586525
49TP53_18474530_ChIP-ChIP_U2OS_Human1.33821322
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33432278
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32512576
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29750630
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.28421380
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28409824
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27751980
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24529325
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23414303
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.23286202
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21849729
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.21378198
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.20662795
62GBX2_23144817_ChIP-Seq_PC3_Human1.19448554
63RNF2_27304074_Chip-Seq_NSC_Mouse1.16989252
64AR_25329375_ChIP-Seq_VCAP_Human1.16840554
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16649359
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.16522470
67STAT1_17558387_ChIP-Seq_HELA_Human1.16070595
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15559126
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14989093
70JUN_21703547_ChIP-Seq_K562_Human1.13224299
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12874022
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.11548232
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09411826
74RUNX2_22187159_ChIP-Seq_PCA_Human1.08891176
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08705742
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08316678
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05734703
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05129618
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.04491124
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04097898
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.03659706
82HOXB7_26014856_ChIP-Seq_BT474_Human1.03175138
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03107371
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01984193
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00873174
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99253320
87NCOR_22424771_ChIP-Seq_293T_Human0.99216129
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.98110518
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97867702
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97486731
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96901463
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96784158
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96622514
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96380547
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96110852
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96010886
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.95459060
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94995652
99CTCF_27219007_Chip-Seq_Bcells_Human0.92802288
100RAC3_21632823_ChIP-Seq_H3396_Human0.92221494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland4.48707430
2MP0005084_abnormal_gallbladder_morpholo4.31253887
3MP0010386_abnormal_urinary_bladder3.86384089
4MP0002102_abnormal_ear_morphology3.73862254
5MP0006276_abnormal_autonomic_nervous3.45810333
6MP0001501_abnormal_sleep_pattern3.37022795
7MP0002822_catalepsy3.26564081
8MP0002132_abnormal_respiratory_system3.12889905
9MP0008877_abnormal_DNA_methylation2.86993376
10MP0003787_abnormal_imprinting2.82090538
11MP0005248_abnormal_Harderian_gland2.29802879
12MP0003880_abnormal_central_pattern2.26763387
13MP0002138_abnormal_hepatobiliary_system2.23851522
14MP0000230_abnormal_systemic_arterial2.23705982
15MP0003136_yellow_coat_color2.10764286
16MP0000015_abnormal_ear_pigmentation1.96429696
17MP0002736_abnormal_nociception_after1.95845984
18MP0003878_abnormal_ear_physiology1.93220544
19MP0005377_hearing/vestibular/ear_phenot1.93220544
20MP0001881_abnormal_mammary_gland1.93026228
21MP0008872_abnormal_physiological_respon1.89658425
22MP0003122_maternal_imprinting1.81099535
23MP0004147_increased_porphyrin_level1.77243946
24MP0003121_genomic_imprinting1.74049484
25MP0005423_abnormal_somatic_nervous1.72691416
26MP0001968_abnormal_touch/_nociception1.68667079
27MP0005671_abnormal_response_to1.56739827
28MP0004133_heterotaxia1.48788527
29MP0003195_calcinosis1.45311667
30MP0003959_abnormal_lean_body1.37586479
31MP0006036_abnormal_mitochondrial_physio1.33199030
32MP0001486_abnormal_startle_reflex1.32411691
33MP0005266_abnormal_metabolism1.27570375
34MP0005171_absent_coat_pigmentation1.27092194
35MP0003252_abnormal_bile_duct1.26461766
36MP0000372_irregular_coat_pigmentation1.26190079
37MP0002735_abnormal_chemical_nociception1.25829193
38MP0002184_abnormal_innervation1.23999726
39MP0009250_abnormal_appendicular_skeleto1.17679124
40MP0002095_abnormal_skin_pigmentation1.17181771
41MP0002277_abnormal_respiratory_mucosa1.16391166
42MP0001188_hyperpigmentation1.16311464
43MP0005332_abnormal_amino_acid1.14848566
44MP0000538_abnormal_urinary_bladder1.14677405
45MP0005551_abnormal_eye_electrophysiolog1.13849066
46MP0002733_abnormal_thermal_nociception1.13586321
47MP0001502_abnormal_circadian_rhythm1.11636206
48MP0002638_abnormal_pupillary_reflex1.10300036
49MP0003879_abnormal_hair_cell1.10093515
50MP0001970_abnormal_pain_threshold1.09841064
51MP0004145_abnormal_muscle_electrophysio1.07537203
52MP0003303_peritoneal_inflammation1.03579394
53MP0003866_abnormal_defecation0.99022050
54MP0005174_abnormal_tail_pigmentation0.96439361
55MP0005410_abnormal_fertilization0.95258489
56MP0004381_abnormal_hair_follicle0.92932188
57MP0004142_abnormal_muscle_tone0.89430066
58MP0003698_abnormal_male_reproductive0.88427448
59MP0009697_abnormal_copulation0.87155632
60MP0000026_abnormal_inner_ear0.86690181
61MP0009780_abnormal_chondrocyte_physiolo0.86147403
62MP0004885_abnormal_endolymph0.85304162
63MP0002272_abnormal_nervous_system0.84656418
64MP0008875_abnormal_xenobiotic_pharmacok0.84267843
65MP0008569_lethality_at_weaning0.83976765
66MP0001664_abnormal_digestion0.83963460
67MP0002752_abnormal_somatic_nervous0.82475696
68MP0009333_abnormal_splenocyte_physiolog0.82249676
69MP0003183_abnormal_peptide_metabolism0.82098339
70MP0003718_maternal_effect0.80051013
71MP0000631_abnormal_neuroendocrine_gland0.78626672
72MP0002136_abnormal_kidney_physiology0.76769833
73MP0001485_abnormal_pinna_reflex0.76624211
74MP0000955_abnormal_spinal_cord0.74876538
75MP0008058_abnormal_DNA_repair0.73816252
76MP0009745_abnormal_behavioral_response0.73269656
77MP0002557_abnormal_social/conspecific_i0.72710463
78MP0003786_premature_aging0.72640234
79MP0000685_abnormal_immune_system0.72437100
80MP0003186_abnormal_redox_activity0.72372892
81MP0001963_abnormal_hearing_physiology0.71835836
82MP0005595_abnormal_vascular_smooth0.70852072
83MP0002928_abnormal_bile_duct0.69214565
84MP0005645_abnormal_hypothalamus_physiol0.68028824
85MP0002210_abnormal_sex_determination0.66893699
86MP0003011_delayed_dark_adaptation0.65573695
87MP0002064_seizures0.64830072
88MP0004134_abnormal_chest_morphology0.63892016
89MP0002882_abnormal_neuron_morphology0.63810953
90MP0002067_abnormal_sensory_capabilities0.62435358
91MP0002734_abnormal_mechanical_nocicepti0.60378929
92MP0000920_abnormal_myelination0.59467632
93MP0003635_abnormal_synaptic_transmissio0.58906207
94MP0009785_altered_susceptibility_to0.58153403
95MP0001756_abnormal_urination0.58084697
96MP0001119_abnormal_female_reproductive0.57589328
97MP0001929_abnormal_gametogenesis0.57527737
98MP0003936_abnormal_reproductive_system0.57173181
99MP0005360_urolithiasis0.55583431
100MP0002229_neurodegeneration0.55282237

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)7.14914388
2Severe visual impairment (HP:0001141)5.89588162
3Cerebral hypomyelination (HP:0006808)4.52292257
4Tubulointerstitial fibrosis (HP:0005576)4.48437611
5Palpebral edema (HP:0100540)3.93673416
6Abnormal drinking behavior (HP:0030082)3.93125888
7Polydipsia (HP:0001959)3.93125888
8Tubular atrophy (HP:0000092)3.90927722
9Keratoconjunctivitis (HP:0001096)3.49110324
10Keratoconjunctivitis sicca (HP:0001097)3.48689856
11Increased intramyocellular lipid droplets (HP:0012240)3.46439409
12Hypoalbuminemia (HP:0003073)3.37233508
13Abnormal albumin level (HP:0012116)3.37233508
14Slow saccadic eye movements (HP:0000514)3.33029573
15Atonic seizures (HP:0010819)3.28126665
16Stage 5 chronic kidney disease (HP:0003774)3.28117063
17Spastic paraparesis (HP:0002313)3.20800039
18Renal Fanconi syndrome (HP:0001994)3.19444228
19Focal segmental glomerulosclerosis (HP:0000097)3.19242536
20Hypophosphatemic rickets (HP:0004912)3.10350395
21Tubulointerstitial abnormality (HP:0001969)3.09972685
22Increased muscle lipid content (HP:0009058)3.05503257
23Glomerulosclerosis (HP:0000096)2.97942495
24Hypoplastic left heart (HP:0004383)2.97050206
25Polyuria (HP:0000103)2.96945109
26Retinal atrophy (HP:0001105)2.95870876
27Increased hepatocellular lipid droplets (HP:0006565)2.94949358
28Mitochondrial inheritance (HP:0001427)2.93143923
29Abnormality of the fetal cardiovascular system (HP:0010948)2.84778234
30Abnormal umbilical cord blood vessels (HP:0011403)2.84778234
31Single umbilical artery (HP:0001195)2.84778234
32Lipid accumulation in hepatocytes (HP:0006561)2.82455963
33Nephronophthisis (HP:0000090)2.74043443
34Growth hormone deficiency (HP:0000824)2.73685900
35Methylmalonic acidemia (HP:0002912)2.70764825
36Hyperphosphaturia (HP:0003109)2.69892217
37Acute necrotizing encephalopathy (HP:0006965)2.65909178
38Hypoplastic heart (HP:0001961)2.58343708
39Vacuolated lymphocytes (HP:0001922)2.57069302
40Increased CSF lactate (HP:0002490)2.55305445
41Aplastic anemia (HP:0001915)2.53292819
42Abnormal mitochondria in muscle tissue (HP:0008316)2.52741876
43Abnormal urine phosphate concentration (HP:0012599)2.52233441
44Amblyopia (HP:0000646)2.51510784
45Elevated erythrocyte sedimentation rate (HP:0003565)2.49825440
46Abnormal urine output (HP:0012590)2.48628130
47Hepatocellular necrosis (HP:0001404)2.48163644
48Pigmentary retinal degeneration (HP:0001146)2.46653762
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44700415
50Exertional dyspnea (HP:0002875)2.42337748
51Oral leukoplakia (HP:0002745)2.39312109
52Keratitis (HP:0000491)2.37504735
53Recurrent corneal erosions (HP:0000495)2.34154691
54Birth length less than 3rd percentile (HP:0003561)2.33890893
55CNS hypomyelination (HP:0003429)2.32405072
56Abnormality of the renal cortex (HP:0011035)2.29033974
57Anomalous pulmonary venous return (HP:0010772)2.28226670
58Progressive macrocephaly (HP:0004481)2.24798263
59Poor speech (HP:0002465)2.21176356
60Glycosuria (HP:0003076)2.20630413
61Abnormality of urine glucose concentration (HP:0011016)2.20630413
62Complete atrioventricular canal defect (HP:0001674)2.17597848
63Abnormality of renal excretion (HP:0011036)2.17419880
64Polyphagia (HP:0002591)2.15414256
65Metaphyseal dysplasia (HP:0100255)2.15356182
66Abnormality of the renal medulla (HP:0100957)2.14234912
67Enlarged epiphyses (HP:0010580)2.12046937
68Hepatic necrosis (HP:0002605)2.05566046
69Congenital sensorineural hearing impairment (HP:0008527)2.05425694
70Cerebral edema (HP:0002181)2.04563359
71Abnormal rod and cone electroretinograms (HP:0008323)2.02808934
72Absence seizures (HP:0002121)2.02487065
73Conical tooth (HP:0000698)2.01061469
74Abnormality of renal resorption (HP:0011038)1.99577818
75Abnormality of the pulmonary veins (HP:0011718)1.98349025
76Choreoathetosis (HP:0001266)1.97700027
77Abnormality of cells of the erythroid lineage (HP:0012130)1.97697078
78True hermaphroditism (HP:0010459)1.96470244
79Epiphyseal dysplasia (HP:0002656)1.94762292
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92340916
81Increased corneal curvature (HP:0100692)1.89801432
82Keratoconus (HP:0000563)1.89801432
83Abnormality of midbrain morphology (HP:0002418)1.89135047
84Molar tooth sign on MRI (HP:0002419)1.89135047
85Abnormality of lateral ventricle (HP:0030047)1.88721054
86Leukodystrophy (HP:0002415)1.88339415
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88273419
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88273419
89Prostate neoplasm (HP:0100787)1.88269362
90Abnormal hemoglobin (HP:0011902)1.87265054
91Bony spicule pigmentary retinopathy (HP:0007737)1.85319862
92Retinitis pigmentosa (HP:0000510)1.85141185
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84082326
94Methylmalonic aciduria (HP:0012120)1.83080602
95Atrioventricular canal defect (HP:0006695)1.81775117
96Acute encephalopathy (HP:0006846)1.81596800
97Absent/shortened dynein arms (HP:0200106)1.81588814
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.81588814
99Lower limb hyperreflexia (HP:0002395)1.79030342
100Abnormality of the tricuspid valve (HP:0001702)1.78895391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.96524456
2BCKDK3.59577976
3MAP3K63.45349048
4MAP3K43.31953445
5PRKD32.97249758
6EIF2AK32.97125788
7CAMKK22.88707331
8MYLK2.72362652
9TESK22.59795206
10CASK2.56524089
11TESK12.56018645
12DAPK12.29581168
13MAP3K92.29496221
14IRAK42.25517124
15MARK12.24445612
16DDR22.22797670
17NEK12.12680178
18CDK192.05352958
19CAMK1D1.95374879
20BRSK21.74476013
21ERBB31.68690937
22KDR1.63811249
23TRIM281.63610157
24MAPK131.61511402
25MAP4K21.60246293
26LATS11.55290974
27LIMK11.47303404
28TXK1.38250116
29MST41.33116599
30STK161.32031452
31EPHA41.23530231
32NUAK11.20057973
33MAP4K11.18949262
34GRK11.13195480
35BMX1.09743974
36PRKCH1.07862547
37OXSR11.05427945
38ITK1.00417429
39TIE11.00274525
40IKBKE0.97345417
41CAMK1G0.96935262
42MAPKAPK30.94692769
43DYRK20.94169157
44VRK10.91097323
45PRKCQ0.86973257
46RPS6KA40.86875847
47BCR0.85654839
48STK390.85287934
49CAMK10.81951364
50ADRBK20.80965786
51PKN10.80343684
52NEK90.80039280
53SIK20.77276734
54DAPK30.73541378
55WNK40.71853304
56ZAP700.70672653
57SIK30.69537082
58CAMKK10.69069892
59PHKG20.67635020
60PHKG10.67635020
61ADRBK10.63595185
62ROCK10.62771798
63PAK30.57174265
64INSRR0.55920328
65FLT30.53719023
66TYRO30.53287563
67MAP2K70.50767265
68CSNK1G20.49537980
69PRKAA10.49233685
70PIK3CA0.47807671
71PAK60.46658257
72CSNK1G30.44899651
73STK38L0.44649439
74CDK30.44233285
75GRK60.43548306
76PLK20.42863864
77ABL20.42561864
78CAMK2B0.42326673
79AURKA0.41983982
80OBSCN0.41845576
81LRRK20.40646259
82SYK0.38349477
83DAPK20.38304802
84STK110.37671803
85CAMK2G0.36973806
86CSNK1G10.36591073
87PINK10.35994973
88BRSK10.35722702
89PRKACA0.34905860
90PRKCE0.34816533
91MAPKAPK50.34225030
92MAPK150.29409825
93PRKACB0.28924798
94PRKG10.24862324
95PRKCA0.24502237
96MAPK70.24426902
97MAPK120.24021534
98NME10.22041474
99MAPKAPK20.20963575
100CAMK2A0.20188460

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.31557115
2Parkinsons disease_Homo sapiens_hsa050123.65966728
3Sulfur relay system_Homo sapiens_hsa041223.36530925
4Cardiac muscle contraction_Homo sapiens_hsa042603.27542227
5SNARE interactions in vesicular transport_Homo sapiens_hsa041303.03621879
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.03102508
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.76317779
8Proteasome_Homo sapiens_hsa030502.59453269
9Circadian rhythm_Homo sapiens_hsa047102.54868665
10Huntingtons disease_Homo sapiens_hsa050162.49010059
11Alzheimers disease_Homo sapiens_hsa050102.42572855
12Protein export_Homo sapiens_hsa030602.35015661
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32548452
14Propanoate metabolism_Homo sapiens_hsa006401.99624200
15Non-homologous end-joining_Homo sapiens_hsa034501.96955852
16Ribosome_Homo sapiens_hsa030101.91345397
17Chemical carcinogenesis_Homo sapiens_hsa052041.89873243
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82230495
19Peroxisome_Homo sapiens_hsa041461.74864604
20Nitrogen metabolism_Homo sapiens_hsa009101.70966112
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67336553
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63946852
23Pyruvate metabolism_Homo sapiens_hsa006201.63647015
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60295661
25Basal transcription factors_Homo sapiens_hsa030221.48986641
26Collecting duct acid secretion_Homo sapiens_hsa049661.43103072
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34150743
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31166203
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29979038
30Tryptophan metabolism_Homo sapiens_hsa003801.21284472
31Primary immunodeficiency_Homo sapiens_hsa053401.18245432
32Starch and sucrose metabolism_Homo sapiens_hsa005001.14750934
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13968273
34Fanconi anemia pathway_Homo sapiens_hsa034601.09236204
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05635019
36Dorso-ventral axis formation_Homo sapiens_hsa043201.01566446
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97226571
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91400358
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87957775
40Taste transduction_Homo sapiens_hsa047420.87945463
41Sulfur metabolism_Homo sapiens_hsa009200.87695130
42RNA degradation_Homo sapiens_hsa030180.85574259
43Linoleic acid metabolism_Homo sapiens_hsa005910.81140565
44T cell receptor signaling pathway_Homo sapiens_hsa046600.81138713
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79947622
46Regulation of autophagy_Homo sapiens_hsa041400.77326495
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74583913
48Caffeine metabolism_Homo sapiens_hsa002320.74022032
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73732603
50Selenocompound metabolism_Homo sapiens_hsa004500.73343536
51Histidine metabolism_Homo sapiens_hsa003400.72630806
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72204072
53Purine metabolism_Homo sapiens_hsa002300.70062508
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66220365
55Salivary secretion_Homo sapiens_hsa049700.65025557
56Nicotine addiction_Homo sapiens_hsa050330.64642307
57Dopaminergic synapse_Homo sapiens_hsa047280.64278056
58Butanoate metabolism_Homo sapiens_hsa006500.63629590
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61463243
60Fatty acid biosynthesis_Homo sapiens_hsa000610.61103620
61Morphine addiction_Homo sapiens_hsa050320.59642432
62Metabolic pathways_Homo sapiens_hsa011000.57162297
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.54807861
64Retinol metabolism_Homo sapiens_hsa008300.51920191
65Fatty acid degradation_Homo sapiens_hsa000710.51586092
66Pyrimidine metabolism_Homo sapiens_hsa002400.51039126
67Glutathione metabolism_Homo sapiens_hsa004800.50968176
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49736637
69Dilated cardiomyopathy_Homo sapiens_hsa054140.48351745
70Glutamatergic synapse_Homo sapiens_hsa047240.47622628
71Oxytocin signaling pathway_Homo sapiens_hsa049210.46981389
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45767237
73Phototransduction_Homo sapiens_hsa047440.43957336
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43565727
75Olfactory transduction_Homo sapiens_hsa047400.42152988
76Ether lipid metabolism_Homo sapiens_hsa005650.41262109
77Hedgehog signaling pathway_Homo sapiens_hsa043400.38459171
78Arginine and proline metabolism_Homo sapiens_hsa003300.37948357
79Vibrio cholerae infection_Homo sapiens_hsa051100.36669060
80Hematopoietic cell lineage_Homo sapiens_hsa046400.36435431
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35444903
82MAPK signaling pathway_Homo sapiens_hsa040100.34842033
83Renin secretion_Homo sapiens_hsa049240.34475603
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31664683
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31442702
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.31006625
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30970986
88Measles_Homo sapiens_hsa051620.30056057
89Lysine degradation_Homo sapiens_hsa003100.26799333
90Calcium signaling pathway_Homo sapiens_hsa040200.25907194
91ECM-receptor interaction_Homo sapiens_hsa045120.25249341
92Mineral absorption_Homo sapiens_hsa049780.24937212
93cAMP signaling pathway_Homo sapiens_hsa040240.24884076
94Rheumatoid arthritis_Homo sapiens_hsa053230.22717973
95Serotonergic synapse_Homo sapiens_hsa047260.22073400
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21971501
97Carbon metabolism_Homo sapiens_hsa012000.21474603
98Axon guidance_Homo sapiens_hsa043600.20070068
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19818931
100beta-Alanine metabolism_Homo sapiens_hsa004100.19419989

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »