ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	7.85668670
2	retinal cone cell development (GO:0046549)	7.15917192
3	piRNA metabolic process (GO:0034587)	6.84396310
4	glycine transport (GO:0015816)	6.31019238
5	regulation of female gonad development (GO:2000194)	6.26967892
6	meiotic cell cycle (GO:0051321)	6.15153650
7	regulation of meiosis I (GO:0060631)	5.19077377
8	DNA methylation involved in gamete generation (GO:0043046)	5.17435962
9	behavioral response to nicotine (GO:0035095)	4.97953563
10	positive regulation of histone H3-K4 methylation (GO:0051571)	4.70395666
11	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.64552941
12	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.64552941
13	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.64552941
14	regulation of acrosome reaction (GO:0060046)	4.50768189
15	female gamete generation (GO:0007292)	4.50366070
16	multicellular organism reproduction (GO:0032504)	4.50174890
17	regulation of steroid hormone secretion (GO:2000831)	3.91355069
18	regulation of cell maturation (GO:1903429)	3.84943260
19	cullin deneddylation (GO:0010388)	3.82406769
20	growth hormone secretion (GO:0030252)	3.82299938
21	synapsis (GO:0007129)	3.78610510
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.78351609
23	protein complex biogenesis (GO:0070271)	3.78322838
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.78272374
25	centriole replication (GO:0007099)	3.78235059
26	phosphorelay signal transduction system (GO:0000160)	3.76186929
27	protein deneddylation (GO:0000338)	3.75508928
28	tryptophan catabolic process (GO:0006569)	3.68061304
29	indole-containing compound catabolic process (GO:0042436)	3.68061304
30	indolalkylamine catabolic process (GO:0046218)	3.68061304
31	positive regulation of gastrulation (GO:2000543)	3.65145806
32	cytochrome complex assembly (GO:0017004)	3.58501256
33	kynurenine metabolic process (GO:0070189)	3.56727467
34	gamma-aminobutyric acid transport (GO:0015812)	3.50257172
35	positive regulation of growth hormone secretion (GO:0060124)	3.48322021
36	glycerophospholipid catabolic process (GO:0046475)	3.42821546
37	regulation of histone H3-K9 methylation (GO:0051570)	3.37338837
38	positive regulation of chromosome segregation (GO:0051984)	3.29863887
39	gene silencing by RNA (GO:0031047)	3.28265029
40	attachment of spindle microtubules to kinetochore (GO:0008608)	3.25564832
41	proteasome assembly (GO:0043248)	3.22738953
42	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.21931000
43	nonmotile primary cilium assembly (GO:0035058)	3.21477124
44	negative regulation of reproductive process (GO:2000242)	3.20178788
45	cellular biogenic amine catabolic process (GO:0042402)	3.17050190
46	amine catabolic process (GO:0009310)	3.17050190
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.15954480
48	DNA double-strand break processing (GO:0000729)	3.09676661
49	male meiosis (GO:0007140)	3.04297672
50	oxidative demethylation (GO:0070989)	3.03553512
51	protein localization to kinetochore (GO:0034501)	3.03059060
52	respiratory chain complex IV assembly (GO:0008535)	3.02249445
53	histone H2A ubiquitination (GO:0033522)	2.98528825
54	substrate-independent telencephalic tangential migration (GO:0021826)	2.98163833
55	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.98163833
56	base-excision repair, AP site formation (GO:0006285)	2.96860585
57	oocyte development (GO:0048599)	2.95293858
58	chromosome organization involved in meiosis (GO:0070192)	2.94716454
59	indolalkylamine metabolic process (GO:0006586)	2.93467301
60	male meiosis I (GO:0007141)	2.93177836
61	regulation of meiosis (GO:0040020)	2.90904828
62	nucleotide transmembrane transport (GO:1901679)	2.86561026
63	tryptophan metabolic process (GO:0006568)	2.85080437
64	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.84778830
65	chromatin remodeling at centromere (GO:0031055)	2.84529328
66	CENP-A containing nucleosome assembly (GO:0034080)	2.83904345
67	DNA replication checkpoint (GO:0000076)	2.82211523
68	synaptonemal complex assembly (GO:0007130)	2.81587635
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.81273346
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.81273346
71	NADH dehydrogenase complex assembly (GO:0010257)	2.81273346
72	epithelial cilium movement (GO:0003351)	2.80902618
73	translesion synthesis (GO:0019985)	2.80138298
74	positive regulation of circadian rhythm (GO:0042753)	2.77852180
75	reproduction (GO:0000003)	2.77596290
76	protein-cofactor linkage (GO:0018065)	2.76697493
77	inositol phosphate dephosphorylation (GO:0046855)	2.75740993
78	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.75740993
79	hydrogen ion transmembrane transport (GO:1902600)	2.75670786
80	neuron fate determination (GO:0048664)	2.75638559
81	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.75582282
82	ATP synthesis coupled proton transport (GO:0015986)	2.75582282
83	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.62900701
84	response to food (GO:0032094)	2.60897551
85	negative regulation of execution phase of apoptosis (GO:1900118)	2.59115832
86	synaptonemal complex organization (GO:0070193)	2.59055666
87	protein localization to chromosome, centromeric region (GO:0071459)	2.58765588
88	positive regulation of steroid hormone secretion (GO:2000833)	2.56429557
89	regulation of G0 to G1 transition (GO:0070316)	2.55270881
90	indole-containing compound metabolic process (GO:0042430)	2.53567050
91	L-amino acid import (GO:0043092)	2.53287886
92	histone exchange (GO:0043486)	2.52364856
93	histone H2A monoubiquitination (GO:0035518)	2.51598723
94	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.51215263
95	response to magnesium ion (GO:0032026)	2.51177297
96	proton transport (GO:0015992)	2.51126312
97	negative regulation of T cell differentiation in thymus (GO:0033085)	2.49773230
98	parturition (GO:0007567)	2.49455496
99	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.48670572
100	water-soluble vitamin biosynthetic process (GO:0042364)	2.47998472

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	9.70386932
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.86747012
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.44123954
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16124562
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.92263909
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.39267522
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.36574477
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.16415879
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05251807
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.03048127
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90103325
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85970948
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.83136149
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81599549
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.81039842
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.77746611
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71958627
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67275488
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65260293
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65181165
21	VDR_22108803_ChIP-Seq_LS180_Human	1.60264874
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.57498257
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56986089
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.56380655
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56337207
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56282913
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56091653
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56091653
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.53786709
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53786709
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49201035
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38979278
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38691225
34	EWS_26573619_Chip-Seq_HEK293_Human	1.38507989
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38085048
36	AR_20517297_ChIP-Seq_VCAP_Human	1.36205447
37	FUS_26573619_Chip-Seq_HEK293_Human	1.31037677
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.27744589
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27629185
40	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.27476478
41	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.27476478
42	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.27476478
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.26833160
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23593892
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.23284543
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22287140
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.21887058
48	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.21329716
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19689565
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19340200
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18513658
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18498765
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17335781
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16015371
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14624261
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12929870
57	TCF4_23295773_ChIP-Seq_U87_Human	1.12806327
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12123131
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11721793
60	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.11042902
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10693900
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.09869039
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.09792356
64	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08720222
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.07546025
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06624850
67	AR_25329375_ChIP-Seq_VCAP_Human	1.06037648
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05886953
69	P300_19829295_ChIP-Seq_ESCs_Human	1.05616794
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05052385
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04322595
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03775594
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03775594
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03627778
75	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03393347
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02782133
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.01264909
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01258519
79	STAT3_23295773_ChIP-Seq_U87_Human	1.01153225
80	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99999410
81	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99789546
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99519204
83	NCOR_22424771_ChIP-Seq_293T_Human	0.99074090
84	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98255019
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97433140
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97257198
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96291954
88	ER_23166858_ChIP-Seq_MCF-7_Human	0.95841997
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95030126
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95030126
91	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94714320
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.93963199
93	IGF1R_20145208_ChIP-Seq_DFB_Human	0.93140462
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93099631
95	CBP_21632823_ChIP-Seq_H3396_Human	0.92861182
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92745205
97	VDR_23849224_ChIP-Seq_CD4+_Human	0.91263875
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90804468
99	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.90545886
100	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.90311340

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	5.73957930
2	MP0008789_abnormal_olfactory_epithelium	3.82797737
3	MP0004142_abnormal_muscle_tone	3.27518775
4	MP0008875_abnormal_xenobiotic_pharmacok	3.02317477
5	MP0005499_abnormal_olfactory_system	3.01571638
6	MP0005394_taste/olfaction_phenotype	3.01571638
7	MP0008877_abnormal_DNA_methylation	2.97439583
8	MP0002638_abnormal_pupillary_reflex	2.66014391
9	MP0002234_abnormal_pharynx_morphology	2.54231248
10	MP0006292_abnormal_olfactory_placode	2.41943345
11	MP0001986_abnormal_taste_sensitivity	2.32260226
12	MP0001502_abnormal_circadian_rhythm	2.24378689
13	MP0003183_abnormal_peptide_metabolism	2.23561906
14	MP0001984_abnormal_olfaction	2.15952216
15	MP0005551_abnormal_eye_electrophysiolog	2.13132233
16	MP0005395_other_phenotype	2.12541101
17	MP0002163_abnormal_gland_morphology	2.12112538
18	MP0002160_abnormal_reproductive_system	2.11592090
19	MP0002138_abnormal_hepatobiliary_system	2.06127239
20	MP0002272_abnormal_nervous_system	2.03693702
21	MP0009379_abnormal_foot_pigmentation	1.82104312
22	MP0003693_abnormal_embryo_hatching	1.75983674
23	MP0005360_urolithiasis	1.75231863
24	MP0003879_abnormal_hair_cell	1.72864127
25	MP0005389_reproductive_system_phenotype	1.71422929
26	MP0003890_abnormal_embryonic-extraembry	1.70283604
27	MP0001929_abnormal_gametogenesis	1.63607008
28	MP0010030_abnormal_orbit_morphology	1.57317082
29	MP0002210_abnormal_sex_determination	1.56297768
30	MP0002139_abnormal_hepatobiliary_system	1.48904163
31	MP0003122_maternal_imprinting	1.48376080
32	MP0000427_abnormal_hair_cycle	1.47062680
33	MP0005670_abnormal_white_adipose	1.46768228
34	MP0003195_calcinosis	1.44408124
35	MP0008058_abnormal_DNA_repair	1.41523683
36	MP0004885_abnormal_endolymph	1.40211442
37	MP0003121_genomic_imprinting	1.38823857
38	MP0002102_abnormal_ear_morphology	1.37715425
39	MP0008872_abnormal_physiological_respon	1.32030091
40	MP0003699_abnormal_female_reproductive	1.31598553
41	MP0005410_abnormal_fertilization	1.30591430
42	MP0001529_abnormal_vocalization	1.29046975
43	MP0009745_abnormal_behavioral_response	1.27257258
44	MP0010094_abnormal_chromosome_stability	1.23756475
45	MP0005085_abnormal_gallbladder_physiolo	1.22504044
46	MP0001968_abnormal_touch/_nociception	1.21864114
47	MP0005646_abnormal_pituitary_gland	1.21002224
48	MP0002734_abnormal_mechanical_nocicepti	1.19965184
49	MP0000653_abnormal_sex_gland	1.18539834
50	MP0004742_abnormal_vestibular_system	1.18410086
51	MP0006072_abnormal_retinal_apoptosis	1.18237844
52	MP0000631_abnormal_neuroendocrine_gland	1.17245289
53	MP0001486_abnormal_startle_reflex	1.14756163
54	MP0003136_yellow_coat_color	1.10148510
55	MP0003880_abnormal_central_pattern	1.09766769
56	MP0002161_abnormal_fertility/fecundity	1.09618018
57	MP0000778_abnormal_nervous_system	1.08832512
58	MP0008775_abnormal_heart_ventricle	1.08749388
59	MP0006276_abnormal_autonomic_nervous	1.07282109
60	MP0001963_abnormal_hearing_physiology	1.07172216
61	MP0003119_abnormal_digestive_system	1.05945620
62	MP0005253_abnormal_eye_physiology	1.05758909
63	MP0002233_abnormal_nose_morphology	1.05706564
64	MP0003252_abnormal_bile_duct	1.03907012
65	MP0001119_abnormal_female_reproductive	1.02052674
66	MP0001145_abnormal_male_reproductive	1.00937523
67	MP0002095_abnormal_skin_pigmentation	1.00503265
68	MP0003646_muscle_fatigue	0.99725206
69	MP0001970_abnormal_pain_threshold	0.97860462
70	MP0009780_abnormal_chondrocyte_physiolo	0.97342069
71	MP0002735_abnormal_chemical_nociception	0.95580523
72	MP0002572_abnormal_emotion/affect_behav	0.95547241
73	MP0002876_abnormal_thyroid_physiology	0.95453753
74	MP0004147_increased_porphyrin_level	0.95009617
75	MP0001905_abnormal_dopamine_level	0.93763136
76	MP0001764_abnormal_homeostasis	0.91707875
77	MP0001324_abnormal_eye_pigmentation	0.90931854
78	MP0000026_abnormal_inner_ear	0.90678761
79	MP0002837_dystrophic_cardiac_calcinosis	0.90237076
80	MP0003698_abnormal_male_reproductive	0.88402233
81	MP0000230_abnormal_systemic_arterial	0.87652540
82	MP0005075_abnormal_melanosome_morpholog	0.86798487
83	MP0002557_abnormal_social/conspecific_i	0.85561236
84	MP0004145_abnormal_muscle_electrophysio	0.83661301
85	MP0003950_abnormal_plasma_membrane	0.78499984
86	MP0003077_abnormal_cell_cycle	0.77469783
87	MP0001664_abnormal_digestion	0.77467443
88	MP0003635_abnormal_synaptic_transmissio	0.76977275
89	MP0005174_abnormal_tail_pigmentation	0.74322304
90	MP0005379_endocrine/exocrine_gland_phen	0.73869453
91	MP0001919_abnormal_reproductive_system	0.73746475
92	MP0003186_abnormal_redox_activity	0.73229526
93	MP0001293_anophthalmia	0.72555696
94	MP0000049_abnormal_middle_ear	0.71340605
95	MP0000015_abnormal_ear_pigmentation	0.70721044
96	MP0005647_abnormal_sex_gland	0.69865044
97	MP0002733_abnormal_thermal_nociception	0.69729249
98	MP0004133_heterotaxia	0.69251956
99	MP0002064_seizures	0.68351881
100	MP0010386_abnormal_urinary_bladder	0.67125258

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	4.64734409
2	Methylmalonic acidemia (HP:0002912)	4.19981977
3	Oligodactyly (hands) (HP:0001180)	3.78312221
4	Methylmalonic aciduria (HP:0012120)	3.42236616
5	Abnormality of midbrain morphology (HP:0002418)	3.41776214
6	Molar tooth sign on MRI (HP:0002419)	3.41776214
7	Medial flaring of the eyebrow (HP:0010747)	3.21049342
8	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.19687057
9	Median cleft lip (HP:0000161)	3.05788850
10	Facial hemangioma (HP:0000329)	3.03660345
11	Gait imbalance (HP:0002141)	3.02259397
12	Congenital, generalized hypertrichosis (HP:0004540)	2.99922502
13	Congenital primary aphakia (HP:0007707)	2.93559269
14	Abnormality of abdominal situs (HP:0011620)	2.91557407
15	Abdominal situs inversus (HP:0003363)	2.91557407
16	Septo-optic dysplasia (HP:0100842)	2.85511835
17	Azoospermia (HP:0000027)	2.79734615
18	Nephrogenic diabetes insipidus (HP:0009806)	2.76945051
19	Anterior segment dysgenesis (HP:0007700)	2.76225996
20	Abnormal biliary tract physiology (HP:0012439)	2.74145819
21	Bile duct proliferation (HP:0001408)	2.74145819
22	Abnormality of homocysteine metabolism (HP:0010919)	2.68138399
23	Homocystinuria (HP:0002156)	2.68138399
24	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.62620830
25	Hypoplasia of the fovea (HP:0007750)	2.62620830
26	Genital tract atresia (HP:0001827)	2.57035108
27	Acute necrotizing encephalopathy (HP:0006965)	2.52191199
28	Short tibia (HP:0005736)	2.51203815
29	Abnormality of the labia minora (HP:0012880)	2.50395488
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.48623822
31	Osteomalacia (HP:0002749)	2.48394194
32	Lip pit (HP:0100267)	2.47636121
33	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.46916815
34	Progressive macrocephaly (HP:0004481)	2.45495006
35	Impulsivity (HP:0100710)	2.44951456
36	Attenuation of retinal blood vessels (HP:0007843)	2.43296874
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.43232304
38	Abnormality of macular pigmentation (HP:0008002)	2.43206826
39	Mitochondrial inheritance (HP:0001427)	2.42028346
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40874295
41	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.39018636
42	Congenital sensorineural hearing impairment (HP:0008527)	2.38521209
43	Hypophosphatemic rickets (HP:0004912)	2.37668853
44	Pendular nystagmus (HP:0012043)	2.36857014
45	Epidermoid cyst (HP:0200040)	2.35677602
46	Abnormality of vitamin B metabolism (HP:0004340)	2.33162777
47	Abnormal ciliary motility (HP:0012262)	2.31723607
48	Vaginal atresia (HP:0000148)	2.31697418
49	Neoplasm of the adrenal cortex (HP:0100641)	2.26972777
50	Chorioretinal atrophy (HP:0000533)	2.26896903
51	Hypokinesia (HP:0002375)	2.25243056
52	Oligodactyly (HP:0012165)	2.24598031
53	Hepatic necrosis (HP:0002605)	2.23003294
54	Abnormality of the fovea (HP:0000493)	2.22251299
55	Hyperglycinemia (HP:0002154)	2.22186830
56	Hepatocellular necrosis (HP:0001404)	2.20874180
57	Myokymia (HP:0002411)	2.20355979
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20161959
59	Absent/shortened dynein arms (HP:0200106)	2.20161959
60	Pancreatic cysts (HP:0001737)	2.20151739
61	Absent septum pellucidum (HP:0001331)	2.18835283
62	Enlarged penis (HP:0000040)	2.18530229
63	Chromsome breakage (HP:0040012)	2.16240164
64	Conjunctival telangiectasia (HP:0000524)	2.15448540
65	Acute encephalopathy (HP:0006846)	2.15158036
66	Pancreatic fibrosis (HP:0100732)	2.14779185
67	3-Methylglutaconic aciduria (HP:0003535)	2.13679197
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13039253
69	Chronic hepatic failure (HP:0100626)	2.11556530
70	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11132269
71	Megaloblastic anemia (HP:0001889)	2.07274210
72	Abnormal spermatogenesis (HP:0008669)	2.06823832
73	Posterior subcapsular cataract (HP:0007787)	2.05868908
74	Spastic paraparesis (HP:0002313)	2.05081274
75	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.02711983
76	Increased CSF lactate (HP:0002490)	2.02296331
77	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99613723
78	Bifid tongue (HP:0010297)	1.98923900
79	Meckel diverticulum (HP:0002245)	1.96717393
80	Abnormal gallbladder physiology (HP:0012438)	1.93273222
81	Cholecystitis (HP:0001082)	1.93273222
82	Thyroid-stimulating hormone excess (HP:0002925)	1.92417742
83	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.90531575
84	Poor coordination (HP:0002370)	1.86973241
85	Neurodegeneration (HP:0002180)	1.86558753
86	Generalized myoclonic seizures (HP:0002123)	1.86486268
87	Postaxial hand polydactyly (HP:0001162)	1.86477877
88	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84980640
89	Astigmatism (HP:0000483)	1.84632033
90	Abnormality of the ileum (HP:0001549)	1.84575877
91	Reticulocytopenia (HP:0001896)	1.83995650
92	Testicular atrophy (HP:0000029)	1.83811993
93	Metaphyseal irregularity (HP:0003025)	1.83780495
94	Retinitis pigmentosa (HP:0000510)	1.81739766
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.81468874
96	Premature ovarian failure (HP:0008209)	1.77897140
97	Tubulointerstitial fibrosis (HP:0005576)	1.77870630
98	Male infertility (HP:0003251)	1.77672558
99	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.77372027
100	Broad foot (HP:0001769)	1.73794867

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	5.20966151
2	MAP3K9	4.58991986
3	MAP3K13	3.46454452
4	ZAK	3.40430547
5	STK24	2.72256902
6	NEK6	2.71105396
7	CDC7	2.32416668
8	FRK	2.30755872
9	MAP4K2	2.27055200
10	NTRK2	2.11536465
11	BRAF	1.95801095
12	PIK3CG	1.78539508
13	EIF2AK3	1.78051987
14	MAP3K12	1.75138145
15	MOS	1.69847495
16	AURKA	1.63361455
17	TTK	1.60060803
18	TRIM28	1.54310699
19	TAOK3	1.50705709
20	MAPK13	1.46211529
21	BMPR1B	1.45954508
22	ADRBK2	1.39154126
23	TIE1	1.32305883
24	PRKCI	1.31839461
25	WNK4	1.25104874
26	NUAK1	1.24897183
27	PKN1	1.24368516
28	STK39	1.23731869
29	PDK2	1.23545305
30	TLK1	1.19856009
31	STK16	1.14932993
32	OXSR1	1.14081616
33	EPHA4	1.13365236
34	RAF1	1.08828716
35	PIK3CA	1.07650902
36	MET	1.02906138
37	TNIK	1.00285174
38	CDK19	0.99621993
39	MKNK2	0.98612079
40	STK38L	0.96561354
41	PLK1	0.96559722
42	CSNK1A1L	0.95601744
43	CDK8	0.93415433
44	GRK1	0.91004260
45	BCR	0.90824184
46	STK3	0.88380373
47	PLK3	0.85278426
48	MST4	0.83243194
49	CSNK1G3	0.82123163
50	PINK1	0.81646523
51	SRPK1	0.80294574
52	NEK2	0.80151189
53	CDK9	0.77391789
54	DYRK1B	0.75585760
55	CSNK1G2	0.72357265
56	INSRR	0.71816753
57	CSNK1G1	0.69001594
58	PHKG1	0.68365935
59	PHKG2	0.68365935
60	CAMKK2	0.67349751
61	PRKG1	0.66804725
62	MARK1	0.66186785
63	ILK	0.65959400
64	NME1	0.65571280
65	CHEK2	0.64300452
66	CDK3	0.63511389
67	MAP2K6	0.63503012
68	DYRK2	0.63412299
69	TGFBR1	0.58231030
70	PIM1	0.58070890
71	MAP3K5	0.56008992
72	BUB1	0.54639575
73	ATR	0.54601499
74	MAP2K7	0.53837838
75	PRKACA	0.52528808
76	CAMK2A	0.52415935
77	WNK1	0.51447033
78	CDK7	0.51199343
79	PIM2	0.50630995
80	CSNK1D	0.49040887
81	PRKCE	0.47390513
82	BRSK1	0.46541797
83	ADRBK1	0.45078463
84	PRKACB	0.44890062
85	RPS6KA5	0.44827863
86	PDK1	0.44644419
87	CAMKK1	0.44322931
88	AURKB	0.43912626
89	CDK5	0.41529089
90	MAP3K4	0.41508598
91	ATM	0.40626407
92	MAPKAPK3	0.39577372
93	RPS6KA4	0.38908152
94	MAP3K8	0.38508583
95	CAMK1	0.37240271
96	CAMK1D	0.37007164
97	KSR2	0.35516047
98	NTRK3	0.33022149
99	EIF2AK1	0.32592085
100	VRK1	0.32411590

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	9.29691711
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.87273123
3	Basal transcription factors_Homo sapiens_hsa03022	2.41988941
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.22836010
5	Parkinsons disease_Homo sapiens_hsa05012	2.10336392
6	Phototransduction_Homo sapiens_hsa04744	2.06162688
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.82398893
8	Nicotine addiction_Homo sapiens_hsa05033	1.81200931
9	Tryptophan metabolism_Homo sapiens_hsa00380	1.76710225
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69721552
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69056295
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67249219
13	Mismatch repair_Homo sapiens_hsa03430	1.62503898
14	Ribosome_Homo sapiens_hsa03010	1.62400742
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57888334
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56126777
17	Protein export_Homo sapiens_hsa03060	1.56013324
18	Huntingtons disease_Homo sapiens_hsa05016	1.51863070
19	Olfactory transduction_Homo sapiens_hsa04740	1.50890092
20	Proteasome_Homo sapiens_hsa03050	1.50388858
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47426984
22	Alzheimers disease_Homo sapiens_hsa05010	1.45885961
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44903064
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43172279
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.42111957
26	Homologous recombination_Homo sapiens_hsa03440	1.40275488
27	RNA degradation_Homo sapiens_hsa03018	1.37315756
28	Cell cycle_Homo sapiens_hsa04110	1.32920097
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.30098177
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.29240229
31	Circadian rhythm_Homo sapiens_hsa04710	1.29121936
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22867527
33	Oocyte meiosis_Homo sapiens_hsa04114	1.22241906
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.21571385
35	RNA polymerase_Homo sapiens_hsa03020	1.19024155
36	Folate biosynthesis_Homo sapiens_hsa00790	1.15431916
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09352630
38	ABC transporters_Homo sapiens_hsa02010	1.08318016
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05392449
40	GABAergic synapse_Homo sapiens_hsa04727	1.04079968
41	Peroxisome_Homo sapiens_hsa04146	1.01487561
42	Base excision repair_Homo sapiens_hsa03410	1.01368620
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.99985566
44	Morphine addiction_Homo sapiens_hsa05032	0.97824109
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97536837
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90709521
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89851495
48	Fatty acid elongation_Homo sapiens_hsa00062	0.87704272
49	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80671160
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77036635
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70398022
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69118774
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67859840
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66714613
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64819043
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63127072
57	One carbon pool by folate_Homo sapiens_hsa00670	0.63031908
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61565679
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.61157425
60	Taste transduction_Homo sapiens_hsa04742	0.60614317
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60574846
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.60395266
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59562804
64	RNA transport_Homo sapiens_hsa03013	0.59341598
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59088562
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.58579794
67	DNA replication_Homo sapiens_hsa03030	0.58041603
68	Purine metabolism_Homo sapiens_hsa00230	0.57892318
69	Metabolic pathways_Homo sapiens_hsa01100	0.57058471
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56809847
71	Butanoate metabolism_Homo sapiens_hsa00650	0.54778022
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.52807447
73	p53 signaling pathway_Homo sapiens_hsa04115	0.51983226
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.50324699
75	Serotonergic synapse_Homo sapiens_hsa04726	0.50288168
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.46001604
77	Bile secretion_Homo sapiens_hsa04976	0.45480628
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44928855
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40510751
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38516478
81	Glutathione metabolism_Homo sapiens_hsa00480	0.37892450
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.37065079
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36844346
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36081040
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35061936
86	Sulfur metabolism_Homo sapiens_hsa00920	0.34321262
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34243864
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26505656
89	Fatty acid degradation_Homo sapiens_hsa00071	0.25834057
90	Histidine metabolism_Homo sapiens_hsa00340	0.25721662
91	Retinol metabolism_Homo sapiens_hsa00830	0.25091435
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.23616645
93	Lysine degradation_Homo sapiens_hsa00310	0.23227468
94	Regulation of autophagy_Homo sapiens_hsa04140	0.23129213
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21509117
96	Insulin secretion_Homo sapiens_hsa04911	0.19904368
97	Propanoate metabolism_Homo sapiens_hsa00640	0.19605493
98	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.18087460
99	Mineral absorption_Homo sapiens_hsa04978	0.17329133
100	Vibrio cholerae infection_Homo sapiens_hsa05110	0.15073944

EIF3KP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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