ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.98745442
2	protein neddylation (GO:0045116)	5.74405412
3	DNA deamination (GO:0045006)	5.54608850
4	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.73732569
5	actin nucleation (GO:0045010)	4.48065924
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.36011054
7	platelet dense granule organization (GO:0060155)	4.07752386
8	iron-sulfur cluster assembly (GO:0016226)	3.88860331
9	metallo-sulfur cluster assembly (GO:0031163)	3.88860331
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.83322474
11	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.83236680
12	purine deoxyribonucleotide catabolic process (GO:0009155)	3.77413879
13	cytidine deamination (GO:0009972)	3.76903401
14	cytidine metabolic process (GO:0046087)	3.76903401
15	cytidine catabolic process (GO:0006216)	3.76903401
16	adaptation of signaling pathway (GO:0023058)	3.73080773
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.69435402
18	ATP synthesis coupled proton transport (GO:0015986)	3.69435402
19	behavioral response to nicotine (GO:0035095)	3.48962611
20	base-excision repair, AP site formation (GO:0006285)	3.38237910
21	respiratory chain complex IV assembly (GO:0008535)	3.34314087
22	proteasome assembly (GO:0043248)	3.33424084
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.32954629
24	protein complex biogenesis (GO:0070271)	3.25469683
25	DNA damage response, detection of DNA damage (GO:0042769)	3.22361182
26	positive regulation of muscle cell apoptotic process (GO:0010661)	3.16758999
27	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.11776495
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.11332785
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10134300
30	negative regulation of T cell differentiation in thymus (GO:0033085)	3.08462581
31	fucose catabolic process (GO:0019317)	3.07553720
32	L-fucose metabolic process (GO:0042354)	3.07553720
33	L-fucose catabolic process (GO:0042355)	3.07553720
34	cellular hyperosmotic response (GO:0071474)	3.04397333
35	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.03957935
36	cytochrome complex assembly (GO:0017004)	3.03889410
37	GPI anchor metabolic process (GO:0006505)	3.03173774
38	piRNA metabolic process (GO:0034587)	3.02728522
39	regulation of glucocorticoid secretion (GO:2000849)	3.00827250
40	peptidyl-threonine dephosphorylation (GO:0035970)	2.92098010
41	negative regulation of telomere maintenance (GO:0032205)	2.90280931
42	inositol phosphate dephosphorylation (GO:0046855)	2.87960707
43	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.87960707
44	oxidative phosphorylation (GO:0006119)	2.83876882
45	positive regulation of protein homodimerization activity (GO:0090073)	2.83315526
46	pseudouridine synthesis (GO:0001522)	2.80093364
47	post-embryonic morphogenesis (GO:0009886)	2.79687226
48	detection of light stimulus involved in sensory perception (GO:0050962)	2.76535262
49	detection of light stimulus involved in visual perception (GO:0050908)	2.76535262
50	ubiquinone biosynthetic process (GO:0006744)	2.74330892
51	activated T cell proliferation (GO:0050798)	2.73313742
52	protein-cofactor linkage (GO:0018065)	2.69511195
53	branched-chain amino acid catabolic process (GO:0009083)	2.69345085
54	GPI anchor biosynthetic process (GO:0006506)	2.68306921
55	regulation of B cell receptor signaling pathway (GO:0050855)	2.65437417
56	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.64718353
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.64520358
58	tRNA modification (GO:0006400)	2.64496555
59	positive regulation of steroid hormone secretion (GO:2000833)	2.63197103
60	hydrogen ion transmembrane transport (GO:1902600)	2.63045823
61	parturition (GO:0007567)	2.62346665
62	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62124892
63	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62124892
64	NADH dehydrogenase complex assembly (GO:0010257)	2.62124892
65	S-adenosylmethionine metabolic process (GO:0046500)	2.61297829
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.61283972
67	deoxyribonucleotide catabolic process (GO:0009264)	2.61061984
68	tRNA processing (GO:0008033)	2.59832065
69	mitochondrial RNA metabolic process (GO:0000959)	2.58530372
70	amino acid salvage (GO:0043102)	2.58315864
71	L-methionine salvage (GO:0071267)	2.58315864
72	L-methionine biosynthetic process (GO:0071265)	2.58315864
73	inositol phosphate catabolic process (GO:0071545)	2.57278474
74	positive regulation of prostaglandin secretion (GO:0032308)	2.55681937
75	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.51858253
76	cornea development in camera-type eye (GO:0061303)	2.50133426
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49347472
78	deoxyribose phosphate catabolic process (GO:0046386)	2.49070801
79	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.48376443
80	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.47182434
81	termination of RNA polymerase III transcription (GO:0006386)	2.47182434
82	postreplication repair (GO:0006301)	2.45453552
83	DNA catabolic process, exonucleolytic (GO:0000738)	2.45094960
84	DNA double-strand break processing (GO:0000729)	2.44617896
85	negative regulation of membrane potential (GO:0045837)	2.44597841
86	proton transport (GO:0015992)	2.44503916
87	replication fork processing (GO:0031297)	2.42059246
88	ATP hydrolysis coupled proton transport (GO:0015991)	2.41128015
89	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.41128015
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.40919624
91	hydrogen transport (GO:0006818)	2.40672762
92	transcription from mitochondrial promoter (GO:0006390)	2.40247278
93	negative regulation of mast cell activation (GO:0033004)	2.38116661
94	positive thymic T cell selection (GO:0045059)	2.37488946
95	ubiquinone metabolic process (GO:0006743)	2.37464304
96	protein deneddylation (GO:0000338)	2.36482215
97	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.36343791
98	regulation of immune response to tumor cell (GO:0002837)	2.36327737
99	regulation of response to tumor cell (GO:0002834)	2.36327737
100	positive regulation of response to tumor cell (GO:0002836)	2.36327737

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.66148895
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.22444126
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.15845412
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.07450947
5	VDR_22108803_ChIP-Seq_LS180_Human	3.04190543
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.04008107
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79625529
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69828383
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.69375120
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56616169
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.48150158
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38689642
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35732199
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29832003
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.27954747
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.27842370
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.27512899
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.16316939
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16239765
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13611780
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06724316
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94124139
23	EWS_26573619_Chip-Seq_HEK293_Human	1.92192156
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.80152685
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.79527844
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.78552655
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75480700
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75185888
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70126302
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60674185
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53981987
32	NCOR_22424771_ChIP-Seq_293T_Human	1.52152988
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51449727
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51449727
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45032613
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.43797911
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40831339
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40503779
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38867107
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37629694
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36293577
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33974635
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.32603856
44	AR_20517297_ChIP-Seq_VCAP_Human	1.30718796
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.30476707
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29807596
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29807596
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.28505180
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.28497923
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28234773
51	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.27280382
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26380586
53	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25730586
54	FUS_26573619_Chip-Seq_HEK293_Human	1.25275292
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23148336
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21989541
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21664006
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.21664006
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19625376
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17983476
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17788360
62	GABP_19822575_ChIP-Seq_HepG2_Human	1.17571847
63	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16936584
64	ERA_21632823_ChIP-Seq_H3396_Human	1.16834012
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15174701
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14699673
67	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.12693755
68	P300_19829295_ChIP-Seq_ESCs_Human	1.12282893
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11021753
70	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10931756
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08890390
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08389338
73	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.06349385
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05617100
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04011754
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03833171
77	GATA3_26560356_Chip-Seq_TH2_Human	1.03783525
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.01785486
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01714353
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01616851
81	P300_27268052_Chip-Seq_Bcells_Human	1.01606017
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01421904
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99990927
84	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99472140
85	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99441972
86	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98466199
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98454259
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98423769
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97380726
90	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97253658
91	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96706167
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95922710
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95314464
94	CIITA_25753668_ChIP-Seq_RAJI_Human	0.94988720
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94491099
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93734210
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92563235
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92240245
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91907552
100	MYB_26560356_Chip-Seq_TH2_Human	0.91323291

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	4.06730695
2	MP0004147_increased_porphyrin_level	3.75052742
3	MP0002102_abnormal_ear_morphology	3.72997784
4	MP0005646_abnormal_pituitary_gland	3.03735827
5	MP0008877_abnormal_DNA_methylation	2.95958392
6	MP0002234_abnormal_pharynx_morphology	2.73845421
7	MP0005379_endocrine/exocrine_gland_phen	2.73024211
8	MP0006072_abnormal_retinal_apoptosis	2.47453621
9	MP0002876_abnormal_thyroid_physiology	2.33540243
10	MP0005623_abnormal_meninges_morphology	2.28470927
11	MP0001188_hyperpigmentation	2.03502290
12	MP0001346_abnormal_lacrimal_gland	1.95404917
13	MP0002837_dystrophic_cardiac_calcinosis	1.94118364
14	MP0005084_abnormal_gallbladder_morpholo	1.92534027
15	MP0006292_abnormal_olfactory_placode	1.92517558
16	MP0003787_abnormal_imprinting	1.89095299
17	MP0005671_abnormal_response_to	1.85917230
18	MP0008058_abnormal_DNA_repair	1.84684164
19	MP0002877_abnormal_melanocyte_morpholog	1.84536519
20	MP0006036_abnormal_mitochondrial_physio	1.73385902
21	MP0001986_abnormal_taste_sensitivity	1.61517905
22	MP0000685_abnormal_immune_system	1.56951855
23	MP0005551_abnormal_eye_electrophysiolog	1.55414990
24	MP0008872_abnormal_physiological_respon	1.47401554
25	MP0003950_abnormal_plasma_membrane	1.46764313
26	MP0003786_premature_aging	1.42832168
27	MP0005075_abnormal_melanosome_morpholog	1.42503749
28	MP0004885_abnormal_endolymph	1.39445228
29	MP0004782_abnormal_surfactant_physiolog	1.39181662
30	MP0010386_abnormal_urinary_bladder	1.37624415
31	MP0002160_abnormal_reproductive_system	1.35442203
32	MP0004043_abnormal_pH_regulation	1.35124756
33	MP0009697_abnormal_copulation	1.33880614
34	MP0004142_abnormal_muscle_tone	1.33601827
35	MP0008875_abnormal_xenobiotic_pharmacok	1.33178967
36	MP0001800_abnormal_humoral_immune	1.30882040
37	MP0002733_abnormal_thermal_nociception	1.29618184
38	MP0003806_abnormal_nucleotide_metabolis	1.28939783
39	MP0000372_irregular_coat_pigmentation	1.25349434
40	MP0003724_increased_susceptibility_to	1.24746735
41	MP0002277_abnormal_respiratory_mucosa	1.24725900
42	MP0004858_abnormal_nervous_system	1.23457664
43	MP0005253_abnormal_eye_physiology	1.22683169
44	MP0002138_abnormal_hepatobiliary_system	1.21605536
45	MP0006035_abnormal_mitochondrial_morpho	1.18963320
46	MP0005389_reproductive_system_phenotype	1.16674873
47	MP0000516_abnormal_urinary_system	1.14981352
48	MP0005367_renal/urinary_system_phenotyp	1.14981352
49	MP0008789_abnormal_olfactory_epithelium	1.14031602
50	MP0003880_abnormal_central_pattern	1.13468126
51	MP0001905_abnormal_dopamine_level	1.12934413
52	MP0003656_abnormal_erythrocyte_physiolo	1.10715052
53	MP0005167_abnormal_blood-brain_barrier	1.07012488
54	MP0003718_maternal_effect	1.06203657
55	MP0008775_abnormal_heart_ventricle	1.06202049
56	MP0009785_altered_susceptibility_to	1.06158529
57	MP0003866_abnormal_defecation	1.05064402
58	MP0009764_decreased_sensitivity_to	1.04684598
59	MP0001968_abnormal_touch/_nociception	1.04485436
60	MP0000049_abnormal_middle_ear	1.01403084
61	MP0005645_abnormal_hypothalamus_physiol	1.00308962
62	MP0009745_abnormal_behavioral_response	0.98747995
63	MP0002735_abnormal_chemical_nociception	0.98289850
64	MP0003646_muscle_fatigue	0.97409275
65	MP0008995_early_reproductive_senescence	0.96347893
66	MP0008007_abnormal_cellular_replicative	0.95304523
67	MP0001919_abnormal_reproductive_system	0.94896543
68	MP0005647_abnormal_sex_gland	0.94404859
69	MP0002166_altered_tumor_susceptibility	0.92934024
70	MP0001501_abnormal_sleep_pattern	0.92283043
71	MP0002723_abnormal_immune_serum	0.90173396
72	MP0002177_abnormal_outer_ear	0.89029093
73	MP0002148_abnormal_hypersensitivity_rea	0.88377821
74	MP0001324_abnormal_eye_pigmentation	0.87812855
75	MP0001764_abnormal_homeostasis	0.87500252
76	MP0000681_abnormal_thyroid_gland	0.87338869
77	MP0001835_abnormal_antigen_presentation	0.86471545
78	MP0004084_abnormal_cardiac_muscle	0.84793186
79	MP0001881_abnormal_mammary_gland	0.84465397
80	MP0006276_abnormal_autonomic_nervous	0.83474316
81	MP0001970_abnormal_pain_threshold	0.83385920
82	MP0001486_abnormal_startle_reflex	0.82725224
83	MP0003121_genomic_imprinting	0.80477394
84	MP0002006_tumorigenesis	0.80141870
85	MP0009333_abnormal_splenocyte_physiolog	0.79100110
86	MP0001440_abnormal_grooming_behavior	0.77461254
87	MP0002452_abnormal_antigen_presenting	0.76677785
88	MP0002272_abnormal_nervous_system	0.74811588
89	MP0001984_abnormal_olfaction	0.71676068
90	MP0002095_abnormal_skin_pigmentation	0.70868858
91	MP0001819_abnormal_immune_cell	0.69244212
92	MP0000689_abnormal_spleen_morphology	0.69122639
93	MP0002420_abnormal_adaptive_immunity	0.68847636
94	MP0002398_abnormal_bone_marrow	0.67100008
95	MP0005636_abnormal_mineral_homeostasis	0.67081651
96	MP0004145_abnormal_muscle_electrophysio	0.66155689
97	MP0000613_abnormal_salivary_gland	0.65925919
98	MP0000013_abnormal_adipose_tissue	0.64896270
99	MP0005387_immune_system_phenotype	0.64526183
100	MP0001790_abnormal_immune_system	0.64526183

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.59383735
2	Prostate neoplasm (HP:0100787)	3.68772748
3	Abolished electroretinogram (ERG) (HP:0000550)	3.62248753
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.35088927
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.35088927
6	Pancreatic fibrosis (HP:0100732)	3.23150223
7	Abnormality of the prostate (HP:0008775)	3.19540930
8	3-Methylglutaconic aciduria (HP:0003535)	3.17981787
9	Chronic hepatic failure (HP:0100626)	3.14308661
10	Mitochondrial inheritance (HP:0001427)	3.03345254
11	Pancreatic cysts (HP:0001737)	3.03066464
12	Hepatic necrosis (HP:0002605)	3.02129693
13	Acute necrotizing encephalopathy (HP:0006965)	3.00389587
14	Hepatocellular necrosis (HP:0001404)	3.00314667
15	Increased serum lactate (HP:0002151)	2.97594746
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87207767
17	True hermaphroditism (HP:0010459)	2.86989901
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.86364866
19	Increased CSF lactate (HP:0002490)	2.80836582
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.77641215
21	Attenuation of retinal blood vessels (HP:0007843)	2.73989343
22	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.72388524
23	IgG deficiency (HP:0004315)	2.60609013
24	Progressive macrocephaly (HP:0004481)	2.54406228
25	Abnormality of T cell physiology (HP:0011840)	2.52242460
26	Molar tooth sign on MRI (HP:0002419)	2.51833676
27	Abnormality of midbrain morphology (HP:0002418)	2.51833676
28	Medial flaring of the eyebrow (HP:0010747)	2.50405870
29	Large for gestational age (HP:0001520)	2.50278287
30	Abnormality of the renal cortex (HP:0011035)	2.44982754
31	Agammaglobulinemia (HP:0004432)	2.44368179
32	Sclerocornea (HP:0000647)	2.41415877
33	Renal cortical cysts (HP:0000803)	2.41244454
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.38308642
35	Optic disc pallor (HP:0000543)	2.37828981
36	Acute encephalopathy (HP:0006846)	2.34407343
37	Nephronophthisis (HP:0000090)	2.33940124
38	Panhypogammaglobulinemia (HP:0003139)	2.33754871
39	Lactic acidosis (HP:0003128)	2.33543353
40	Autoimmune hemolytic anemia (HP:0001890)	2.32786889
41	Abnormality of the renal collecting system (HP:0004742)	2.31951456
42	Stomach cancer (HP:0012126)	2.27701431
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25905005
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.19789493
45	Agitation (HP:0000713)	2.19163184
46	Constricted visual fields (HP:0001133)	2.15966743
47	Progressive inability to walk (HP:0002505)	2.13100202
48	Duplicated collecting system (HP:0000081)	2.11523968
49	Abnormality of T cells (HP:0002843)	2.10933661
50	Keratoconus (HP:0000563)	2.09548767
51	Increased corneal curvature (HP:0100692)	2.09548767
52	Tubular atrophy (HP:0000092)	2.07685049
53	Cerebral edema (HP:0002181)	2.07336154
54	Increased hepatocellular lipid droplets (HP:0006565)	2.05993573
55	Supernumerary spleens (HP:0009799)	2.05543395
56	Pendular nystagmus (HP:0012043)	2.04281474
57	Increased IgM level (HP:0003496)	2.03767859
58	Gait imbalance (HP:0002141)	2.03720491
59	Decreased central vision (HP:0007663)	2.03399040
60	Occipital encephalocele (HP:0002085)	2.03269273
61	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00035281
62	Abnormal protein N-linked glycosylation (HP:0012347)	2.00035281
63	Abnormal protein glycosylation (HP:0012346)	2.00035281
64	Abnormal glycosylation (HP:0012345)	2.00035281
65	Abnormality of B cell number (HP:0010975)	1.99045392
66	Nephrogenic diabetes insipidus (HP:0009806)	1.98478751
67	Cutaneous melanoma (HP:0012056)	1.97738328
68	Type 2 muscle fiber atrophy (HP:0003554)	1.97141710
69	Cerebral hypomyelination (HP:0006808)	1.96764294
70	Elevated erythrocyte sedimentation rate (HP:0003565)	1.95846503
71	Polydipsia (HP:0001959)	1.95623055
72	Abnormal drinking behavior (HP:0030082)	1.95623055
73	Lipid accumulation in hepatocytes (HP:0006561)	1.95606721
74	Chronic sinusitis (HP:0011109)	1.95129625
75	Congenital primary aphakia (HP:0007707)	1.93753101
76	Abnormal biliary tract physiology (HP:0012439)	1.89553808
77	Bile duct proliferation (HP:0001408)	1.89553808
78	Inability to walk (HP:0002540)	1.89198636
79	Autoimmune thrombocytopenia (HP:0001973)	1.89148325
80	Abnormality of the middle phalanges of the toes (HP:0010183)	1.87441607
81	Hypoproteinemia (HP:0003075)	1.86137836
82	Increased intramyocellular lipid droplets (HP:0012240)	1.84863115
83	Abnormality of the renal medulla (HP:0100957)	1.84622988
84	Poor speech (HP:0002465)	1.84252596
85	Cystic liver disease (HP:0006706)	1.82723515
86	Delayed CNS myelination (HP:0002188)	1.82101231
87	Abnormality of the pons (HP:0007361)	1.80304938
88	Intestinal atresia (HP:0011100)	1.79106373
89	Abnormality of male internal genitalia (HP:0000022)	1.78868540
90	Methylmalonic acidemia (HP:0002912)	1.75532433
91	Congenital malformation of the right heart (HP:0011723)	1.75383099
92	Double outlet right ventricle (HP:0001719)	1.75383099
93	Methylmalonic aciduria (HP:0012120)	1.74922759
94	Neonatal respiratory distress (HP:0002643)	1.74866069
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.73148317
96	Gastrointestinal atresia (HP:0002589)	1.73036847
97	Postaxial foot polydactyly (HP:0001830)	1.72805582
98	CNS hypomyelination (HP:0003429)	1.71933693
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71481197
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.69676586

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	5.35423677
2	GRK1	3.85373038
3	TIE1	3.54713146
4	KDR	2.83451004
5	BCKDK	2.82469300
6	VRK2	2.59737262
7	FRK	2.35739817
8	BCR	2.32989681
9	CSNK1G3	2.18927304
10	MAP4K2	2.08815186
11	EIF2AK3	2.06118176
12	BMPR1B	2.04422666
13	CDK19	1.97768686
14	ADRBK2	1.96363032
15	TRIM28	1.93867127
16	TXK	1.89326953
17	TLK1	1.85682141
18	MAPKAPK3	1.85272250
19	CSNK1G2	1.74389943
20	NUAK1	1.72609728
21	ZAK	1.72492205
22	CSNK1G1	1.71761725
23	CSNK1A1L	1.68917607
24	TAOK3	1.52847704
25	FES	1.49147563
26	DAPK1	1.43136971
27	VRK1	1.42535704
28	OXSR1	1.38379782
29	WNK4	1.30778615
30	LIMK1	1.23081449
31	SYK	1.21303673
32	DYRK2	1.17393759
33	ITK	1.10162964
34	ERBB3	1.09093999
35	PDK2	1.07017975
36	IKBKB	1.02561604
37	EIF2AK1	1.00377548
38	TEC	0.97436209
39	PINK1	0.97197214
40	PHKG1	0.97182390
41	PHKG2	0.97182390
42	MAPK13	0.94137216
43	BUB1	0.90930936
44	EIF2AK2	0.86113835
45	RPS6KA4	0.81056792
46	PLK3	0.80848867
47	DAPK2	0.79844218
48	STK39	0.79478153
49	CDK8	0.78589708
50	MST4	0.78277263
51	MAP3K12	0.70376897
52	IKBKE	0.70110080
53	CSNK1A1	0.67794510
54	MAP4K1	0.66510472
55	MAP2K6	0.66395592
56	CAMKK2	0.66364307
57	WNK3	0.62456016
58	MAP2K2	0.61726689
59	PLK2	0.61483025
60	TBK1	0.61156111
61	PRKCQ	0.61100144
62	RPS6KA5	0.60957477
63	KIT	0.58421942
64	TAF1	0.56876542
65	STK11	0.54215538
66	MAPKAPK5	0.53877954
67	CCNB1	0.53409262
68	ATR	0.53065897
69	CDK9	0.52754062
70	CDK7	0.50268608
71	LYN	0.47892250
72	MINK1	0.45646192
73	PRKCE	0.45546652
74	MAP3K14	0.45515527
75	INSRR	0.45212065
76	TGFBR1	0.44622617
77	MAP2K7	0.44490464
78	SRPK1	0.40920437
79	BMPR2	0.38440991
80	CSNK2A1	0.38339885
81	PRKACA	0.37702818
82	PAK3	0.34991225
83	MAP3K4	0.31643072
84	NME1	0.30298825
85	DYRK1A	0.29451961
86	PRKCA	0.28899379
87	MAPK12	0.26994606
88	PRKAA1	0.26891945
89	PRKCI	0.26768143
90	GRK6	0.26635775
91	STK3	0.25803623
92	GRK5	0.25059199
93	ADRBK1	0.24219976
94	CSNK1D	0.23889082
95	IGF1R	0.23628690
96	DYRK1B	0.22952855
97	CSNK2A2	0.21406647
98	CSF1R	0.20273781
99	BRSK2	0.19271235
100	LCK	0.18290139

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.08947207
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.76514112
3	Asthma_Homo sapiens_hsa05310	2.62942589
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.57518174
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43888591
6	Allograft rejection_Homo sapiens_hsa05330	2.39080207
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.35368876
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.34270650
9	Phototransduction_Homo sapiens_hsa04744	2.27060511
10	Parkinsons disease_Homo sapiens_hsa05012	2.25062492
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.24363252
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.22476025
13	Protein export_Homo sapiens_hsa03060	2.18929431
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.08260257
15	Basal transcription factors_Homo sapiens_hsa03022	2.02570062
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.95626646
17	Homologous recombination_Homo sapiens_hsa03440	1.79609356
18	Sulfur relay system_Homo sapiens_hsa04122	1.71946786
19	Peroxisome_Homo sapiens_hsa04146	1.68222100
20	RNA polymerase_Homo sapiens_hsa03020	1.67969520
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.65906044
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.63657175
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55589923
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.50442608
25	Butanoate metabolism_Homo sapiens_hsa00650	1.49314003
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45860601
27	One carbon pool by folate_Homo sapiens_hsa00670	1.44985770
28	Propanoate metabolism_Homo sapiens_hsa00640	1.44822540
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.43265948
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40101676
31	Alzheimers disease_Homo sapiens_hsa05010	1.34286799
32	RNA degradation_Homo sapiens_hsa03018	1.27980882
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.27517586
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25051678
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23408405
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21304646
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13848473
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13591750
39	Base excision repair_Homo sapiens_hsa03410	1.12461533
40	Purine metabolism_Homo sapiens_hsa00230	1.11806892
41	Huntingtons disease_Homo sapiens_hsa05016	1.11789112
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08838372
43	Fatty acid elongation_Homo sapiens_hsa00062	0.99093332
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.99076864
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.99008759
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97816779
47	Caffeine metabolism_Homo sapiens_hsa00232	0.95390941
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93875481
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93011632
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91901028
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.89788893
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.88101189
53	p53 signaling pathway_Homo sapiens_hsa04115	0.87901814
54	Ribosome_Homo sapiens_hsa03010	0.87752900
55	RNA transport_Homo sapiens_hsa03013	0.86954626
56	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.85794159
57	Nicotine addiction_Homo sapiens_hsa05033	0.84101281
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84016643
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82973108
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81606313
61	Herpes simplex infection_Homo sapiens_hsa05168	0.80902023
62	Retinol metabolism_Homo sapiens_hsa00830	0.77570503
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74941137
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.73027695
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71872946
66	DNA replication_Homo sapiens_hsa03030	0.70858107
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.67158192
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66882036
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66625141
70	Metabolic pathways_Homo sapiens_hsa01100	0.66620971
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64713047
72	Sulfur metabolism_Homo sapiens_hsa00920	0.64050581
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60875799
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58546361
75	Viral myocarditis_Homo sapiens_hsa05416	0.57364402
76	Regulation of autophagy_Homo sapiens_hsa04140	0.56266029
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55758185
78	Spliceosome_Homo sapiens_hsa03040	0.55560725
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54441179
80	Mismatch repair_Homo sapiens_hsa03430	0.52870213
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51311468
82	Olfactory transduction_Homo sapiens_hsa04740	0.48204151
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47454835
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44548540
85	GABAergic synapse_Homo sapiens_hsa04727	0.43369200
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42686922
87	Morphine addiction_Homo sapiens_hsa05032	0.41968778
88	Salivary secretion_Homo sapiens_hsa04970	0.41646835
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.41213822
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40682042
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.39667523
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39615903
93	Serotonergic synapse_Homo sapiens_hsa04726	0.39167376
94	Insulin secretion_Homo sapiens_hsa04911	0.38933802
95	Taste transduction_Homo sapiens_hsa04742	0.38469032
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.37655842
97	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.36026079
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30448317
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.30411414
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29813767

EIF3LP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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