ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.89127665
2	viral transcription (GO:0019083)	6.44982732
3	translational termination (GO:0006415)	6.24235380
4	translational elongation (GO:0006414)	5.44788903
5	DNA deamination (GO:0045006)	5.28441838
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.24068397
7	cotranslational protein targeting to membrane (GO:0006613)	5.20466719
8	protein targeting to ER (GO:0045047)	5.11790184
9	behavioral response to nicotine (GO:0035095)	5.05625907
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.96634395
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.91986184
12	cellular protein complex disassembly (GO:0043624)	4.78487667
13	protein localization to endoplasmic reticulum (GO:0070972)	4.75604284
14	response to pheromone (GO:0019236)	4.71677126
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.62605096
16	ATP synthesis coupled proton transport (GO:0015986)	4.62605096
17	viral life cycle (GO:0019058)	4.61748665
18	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.57349973
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.39805136
20	translational initiation (GO:0006413)	4.29148535
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.25793249
22	sequestering of actin monomers (GO:0042989)	4.19418682
23	cytidine deamination (GO:0009972)	4.13590974
24	cytidine metabolic process (GO:0046087)	4.13590974
25	cytidine catabolic process (GO:0006216)	4.13590974
26	ribosomal large subunit biogenesis (GO:0042273)	4.05830594
27	protein complex disassembly (GO:0043241)	4.00903530
28	nonmotile primary cilium assembly (GO:0035058)	3.86239742
29	chaperone-mediated protein transport (GO:0072321)	3.83739828
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.80762659
31	macromolecular complex disassembly (GO:0032984)	3.80512165
32	otic vesicle formation (GO:0030916)	3.68979848
33	maturation of SSU-rRNA (GO:0030490)	3.66623402
34	electron transport chain (GO:0022900)	3.60270403
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.58683315
36	respiratory electron transport chain (GO:0022904)	3.57802996
37	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.53916393
38	cellular ketone body metabolic process (GO:0046950)	3.33765392
39	protein targeting to membrane (GO:0006612)	3.31163854
40	ribosomal small subunit biogenesis (GO:0042274)	3.19793844
41	protein neddylation (GO:0045116)	3.15801461
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.13314214
43	translation (GO:0006412)	3.12137427
44	protein complex biogenesis (GO:0070271)	3.11906547
45	mRNA catabolic process (GO:0006402)	2.98838857
46	ketone body metabolic process (GO:1902224)	2.98723845
47	tachykinin receptor signaling pathway (GO:0007217)	2.97457670
48	neuron fate determination (GO:0048664)	2.94733090
49	epithelial cilium movement (GO:0003351)	2.93447784
50	somite development (GO:0061053)	2.93127352
51	sulfation (GO:0051923)	2.89598851
52	protein polyglutamylation (GO:0018095)	2.88633873
53	platelet dense granule organization (GO:0060155)	2.88452458
54	synaptic transmission, cholinergic (GO:0007271)	2.88448059
55	protein-cofactor linkage (GO:0018065)	2.88080862
56	limb bud formation (GO:0060174)	2.85761750
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.84652320
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.84652320
59	NADH dehydrogenase complex assembly (GO:0010257)	2.84652320
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76842966
61	proteasome assembly (GO:0043248)	2.75271280
62	kidney morphogenesis (GO:0060993)	2.74405163
63	hydrogen ion transmembrane transport (GO:1902600)	2.72900889
64	positive regulation of protein homodimerization activity (GO:0090073)	2.71067753
65	negative regulation by host of viral transcription (GO:0043922)	2.69418561
66	axonemal dynein complex assembly (GO:0070286)	2.69159009
67	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66127720
68	GPI anchor metabolic process (GO:0006505)	2.62483395
69	resolution of meiotic recombination intermediates (GO:0000712)	2.62370941
70	RNA catabolic process (GO:0006401)	2.61105176
71	regulation of cilium movement (GO:0003352)	2.59275335
72	ATP biosynthetic process (GO:0006754)	2.58935607
73	piRNA metabolic process (GO:0034587)	2.57130562
74	proton transport (GO:0015992)	2.54754927
75	regulation of feeding behavior (GO:0060259)	2.53961740
76	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.53709515
77	negative regulation of telomere maintenance (GO:0032205)	2.52694396
78	fucose catabolic process (GO:0019317)	2.51711872
79	L-fucose metabolic process (GO:0042354)	2.51711872
80	L-fucose catabolic process (GO:0042355)	2.51711872
81	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.50618787
82	hydrogen transport (GO:0006818)	2.49133365
83	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.47413889
84	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.47179827
85	actin nucleation (GO:0045010)	2.45215557
86	DNA demethylation (GO:0080111)	2.45165207
87	DNA double-strand break processing (GO:0000729)	2.43806462
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.41724473
89	lateral sprouting from an epithelium (GO:0060601)	2.41271976
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.40808674
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.40690555
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.40519358
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.40519358
94	cilium morphogenesis (GO:0060271)	2.39584082
95	negative regulation of appetite (GO:0032099)	2.39509737
96	negative regulation of response to food (GO:0032096)	2.39509737
97	kynurenine metabolic process (GO:0070189)	2.39416753
98	tryptophan catabolic process (GO:0006569)	2.37276783
99	indole-containing compound catabolic process (GO:0042436)	2.37276783
100	indolalkylamine catabolic process (GO:0046218)	2.37276783

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.87140500
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39310040
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.23286728
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.20542048
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.84819673
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.76832842
7	VDR_22108803_ChIP-Seq_LS180_Human	2.71355730
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.60650466
9	EWS_26573619_Chip-Seq_HEK293_Human	2.57715032
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52305477
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.51717528
12	FUS_26573619_Chip-Seq_HEK293_Human	2.40985965
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35661737
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.30151093
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.26518896
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24237580
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14734511
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14552316
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.09385999
20	GBX2_23144817_ChIP-Seq_PC3_Human	2.08823455
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93896874
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89904590
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88543096
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86796279
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.85952560
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84920392
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.83426437
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80944557
29	P300_19829295_ChIP-Seq_ESCs_Human	1.76406630
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.70396122
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.66459707
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65830977
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64674134
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61090292
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48984916
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46779942
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46173958
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.40868349
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40397415
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.37142418
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36348908
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.36348908
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.35485553
44	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33871280
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33626623
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32783166
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32783166
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31424212
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31424212
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.30846121
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29824532
52	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29190823
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28483508
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.25097293
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24651042
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23970096
57	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.22172006
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.21297458
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18952455
60	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.18860585
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18063038
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16739668
63	NCOR_22424771_ChIP-Seq_293T_Human	1.16190194
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15975940
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.15159449
66	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13232026
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13206073
68	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.11812130
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11784374
70	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06496710
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05868794
72	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04697028
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04561243
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04308443
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04104054
76	AR_25329375_ChIP-Seq_VCAP_Human	1.03420128
77	AR_20517297_ChIP-Seq_VCAP_Human	1.01118206
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.00934748
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00907403
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00176267
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.99659176
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99348813
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99348813
84	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98922449
85	SMAD4_21799915_ChIP-Seq_A2780_Human	0.97478477
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97187951
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97131321
88	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95749704
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95210788
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.95162168
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.94578586
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94304425
93	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.94166783
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94082532
95	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93967158
96	FOXP3_21729870_ChIP-Seq_TREG_Human	0.93555516
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92907563
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.92505727
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92413448
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91670672

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.48668545
2	MP0003136_yellow_coat_color	2.93353147
3	MP0006292_abnormal_olfactory_placode	2.41005413
4	MP0008877_abnormal_DNA_methylation	2.40104214
5	MP0006072_abnormal_retinal_apoptosis	2.36237481
6	MP0002102_abnormal_ear_morphology	2.31672418
7	MP0004885_abnormal_endolymph	2.26752585
8	MP0000372_irregular_coat_pigmentation	2.24176144
9	MP0008789_abnormal_olfactory_epithelium	2.22456569
10	MP0010030_abnormal_orbit_morphology	2.21819786
11	MP0001529_abnormal_vocalization	2.19410866
12	MP0002653_abnormal_ependyma_morphology	2.09780700
13	MP0005646_abnormal_pituitary_gland	1.97364310
14	MP0002638_abnormal_pupillary_reflex	1.96738247
15	MP0001485_abnormal_pinna_reflex	1.96250331
16	MP0004145_abnormal_muscle_electrophysio	1.89389910
17	MP0004142_abnormal_muscle_tone	1.88427814
18	MP0002938_white_spotting	1.87746452
19	MP0002234_abnormal_pharynx_morphology	1.83169014
20	MP0002277_abnormal_respiratory_mucosa	1.78844009
21	MP0003938_abnormal_ear_development	1.76436498
22	MP0005253_abnormal_eye_physiology	1.74632607
23	MP0001346_abnormal_lacrimal_gland	1.69335944
24	MP0000631_abnormal_neuroendocrine_gland	1.68775090
25	MP0005551_abnormal_eye_electrophysiolog	1.66684137
26	MP0005394_taste/olfaction_phenotype	1.64991192
27	MP0005499_abnormal_olfactory_system	1.64991192
28	MP0000566_synostosis	1.57859010
29	MP0001968_abnormal_touch/_nociception	1.55959943
30	MP0004742_abnormal_vestibular_system	1.53094507
31	MP0002837_dystrophic_cardiac_calcinosis	1.50778835
32	MP0000778_abnormal_nervous_system	1.48530387
33	MP0008995_early_reproductive_senescence	1.48194639
34	MP0003880_abnormal_central_pattern	1.45572146
35	MP0005084_abnormal_gallbladder_morpholo	1.43759814
36	MP0000049_abnormal_middle_ear	1.42228652
37	MP0001984_abnormal_olfaction	1.41700189
38	MP0005671_abnormal_response_to	1.41061333
39	MP0002282_abnormal_trachea_morphology	1.38495684
40	MP0000026_abnormal_inner_ear	1.38432962
41	MP0003011_delayed_dark_adaptation	1.36182009
42	MP0001188_hyperpigmentation	1.35970379
43	MP0004133_heterotaxia	1.35681929
44	MP0008875_abnormal_xenobiotic_pharmacok	1.34044892
45	MP0002736_abnormal_nociception_after	1.33587217
46	MP0003567_abnormal_fetal_cardiomyocyte	1.31245872
47	MP0002735_abnormal_chemical_nociception	1.29966036
48	MP0003283_abnormal_digestive_organ	1.29608316
49	MP0004147_increased_porphyrin_level	1.28871314
50	MP0005075_abnormal_melanosome_morpholog	1.28744065
51	MP0009745_abnormal_behavioral_response	1.21859056
52	MP0002095_abnormal_skin_pigmentation	1.15722987
53	MP0002822_catalepsy	1.14778518
54	MP0008872_abnormal_physiological_respon	1.12447571
55	MP0001764_abnormal_homeostasis	1.12120368
56	MP0006276_abnormal_autonomic_nervous	1.11010737
57	MP0002272_abnormal_nervous_system	1.10238588
58	MP0005187_abnormal_penis_morphology	1.08591678
59	MP0001486_abnormal_startle_reflex	1.05941802
60	MP0005195_abnormal_posterior_eye	1.04118996
61	MP0005174_abnormal_tail_pigmentation	1.01736783
62	MP0003315_abnormal_perineum_morphology	1.01053559
63	MP0003119_abnormal_digestive_system	1.00325300
64	MP0005645_abnormal_hypothalamus_physiol	0.98963139
65	MP0002752_abnormal_somatic_nervous	0.98388387
66	MP0001905_abnormal_dopamine_level	0.98277346
67	MP0002572_abnormal_emotion/affect_behav	0.95893374
68	MP0001963_abnormal_hearing_physiology	0.95569065
69	MP0001293_anophthalmia	0.94656621
70	MP0005389_reproductive_system_phenotype	0.93840818
71	MP0002733_abnormal_thermal_nociception	0.93242899
72	MP0002160_abnormal_reproductive_system	0.91419811
73	MP0010386_abnormal_urinary_bladder	0.91013539
74	MP0002233_abnormal_nose_morphology	0.89571900
75	MP0001986_abnormal_taste_sensitivity	0.89495854
76	MP0005391_vision/eye_phenotype	0.89323772
77	MP0001970_abnormal_pain_threshold	0.89096357
78	MP0002928_abnormal_bile_duct	0.88124635
79	MP0000569_abnormal_digit_pigmentation	0.87582877
80	MP0002163_abnormal_gland_morphology	0.86184264
81	MP0005248_abnormal_Harderian_gland	0.85704519
82	MP0002557_abnormal_social/conspecific_i	0.85527022
83	MP0005167_abnormal_blood-brain_barrier	0.84977239
84	MP0002751_abnormal_autonomic_nervous	0.84914993
85	MP0003635_abnormal_synaptic_transmissio	0.84117200
86	MP0009250_abnormal_appendicular_skeleto	0.81594673
87	MP0003718_maternal_effect	0.81561686
88	MP0003183_abnormal_peptide_metabolism	0.80774849
89	MP0002184_abnormal_innervation	0.80684628
90	MP0002138_abnormal_hepatobiliary_system	0.79327584
91	MP0001919_abnormal_reproductive_system	0.78339669
92	MP0002063_abnormal_learning/memory/cond	0.76963608
93	MP0001929_abnormal_gametogenesis	0.74962846
94	MP0002210_abnormal_sex_determination	0.74885060
95	MP0009697_abnormal_copulation	0.74740201
96	MP0002064_seizures	0.73323283
97	MP0000230_abnormal_systemic_arterial	0.73110002
98	MP0003137_abnormal_impulse_conducting	0.72798161
99	MP0002067_abnormal_sensory_capabilities	0.72578333
100	MP0003937_abnormal_limbs/digits/tail_de	0.72252845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.56417504
2	Pancreatic cysts (HP:0001737)	4.00598606
3	Absent/shortened dynein arms (HP:0200106)	3.98863510
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.98863510
5	Pancreatic fibrosis (HP:0100732)	3.89898644
6	Abnormality of midbrain morphology (HP:0002418)	3.84986249
7	Molar tooth sign on MRI (HP:0002419)	3.84986249
8	Acute necrotizing encephalopathy (HP:0006965)	3.62181118
9	Mitochondrial inheritance (HP:0001427)	3.55541622
10	Reticulocytopenia (HP:0001896)	3.48493556
11	Congenital stationary night blindness (HP:0007642)	3.42460486
12	Medial flaring of the eyebrow (HP:0010747)	3.38915073
13	Increased hepatocellular lipid droplets (HP:0006565)	3.32582006
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.31734922
15	Abnormal number of erythroid precursors (HP:0012131)	3.31405063
16	Nephronophthisis (HP:0000090)	3.31026165
17	Abnormal ciliary motility (HP:0012262)	3.27592700
18	Abnormal respiratory motile cilium morphology (HP:0005938)	3.25678883
19	Abnormal respiratory epithelium morphology (HP:0012253)	3.25678883
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.18622394
21	Increased CSF lactate (HP:0002490)	3.13991209
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12344685
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.05419186
24	3-Methylglutaconic aciduria (HP:0003535)	3.05209535
25	Lipid accumulation in hepatocytes (HP:0006561)	2.96242561
26	Progressive macrocephaly (HP:0004481)	2.92203229
27	Hepatic necrosis (HP:0002605)	2.80995060
28	Hepatocellular necrosis (HP:0001404)	2.80522262
29	Acute encephalopathy (HP:0006846)	2.79954800
30	Renal Fanconi syndrome (HP:0001994)	2.79310944
31	Cystic liver disease (HP:0006706)	2.73135302
32	Sclerocornea (HP:0000647)	2.71179726
33	Gait imbalance (HP:0002141)	2.65441712
34	Congenital primary aphakia (HP:0007707)	2.62665070
35	Anencephaly (HP:0002323)	2.58900001
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.57927178
37	Abnormality of the renal medulla (HP:0100957)	2.57704719
38	Nephrogenic diabetes insipidus (HP:0009806)	2.55703013
39	Macrocytic anemia (HP:0001972)	2.54539578
40	Supernumerary spleens (HP:0009799)	2.54315246
41	Septo-optic dysplasia (HP:0100842)	2.53179301
42	Abolished electroretinogram (ERG) (HP:0000550)	2.49087398
43	Concave nail (HP:0001598)	2.47446385
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45533703
45	Optic disc pallor (HP:0000543)	2.45200690
46	Hyperglycinemia (HP:0002154)	2.41403354
47	Cerebral edema (HP:0002181)	2.34385309
48	Male pseudohermaphroditism (HP:0000037)	2.27320976
49	Abnormal biliary tract physiology (HP:0012439)	2.26115214
50	Bile duct proliferation (HP:0001408)	2.26115214
51	Generalized aminoaciduria (HP:0002909)	2.25810696
52	Chronic sinusitis (HP:0011109)	2.25001179
53	Increased intramyocellular lipid droplets (HP:0012240)	2.24213764
54	Abnormality of the renal cortex (HP:0011035)	2.23861428
55	Type I transferrin isoform profile (HP:0003642)	2.22871305
56	Asplenia (HP:0001746)	2.22515536
57	Renal cortical cysts (HP:0000803)	2.20565528
58	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.20002349
59	Methylmalonic acidemia (HP:0002912)	2.19499899
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.17858134
61	Congenital hepatic fibrosis (HP:0002612)	2.17213145
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16700726
63	Pallor (HP:0000980)	2.16556387
64	Postaxial foot polydactyly (HP:0001830)	2.15934603
65	Abnormality of urine glucose concentration (HP:0011016)	2.10850131
66	Glycosuria (HP:0003076)	2.10850131
67	Vaginal atresia (HP:0000148)	2.09988747
68	Increased corneal curvature (HP:0100692)	2.08544791
69	Keratoconus (HP:0000563)	2.08544791
70	Colon cancer (HP:0003003)	2.08058008
71	Severe combined immunodeficiency (HP:0004430)	2.06972112
72	Abnormality of the renal collecting system (HP:0004742)	2.06864425
73	Decreased central vision (HP:0007663)	2.06657059
74	Furrowed tongue (HP:0000221)	2.04766744
75	Absent septum pellucidum (HP:0001331)	2.04423967
76	Genital tract atresia (HP:0001827)	2.04005535
77	Exertional dyspnea (HP:0002875)	2.02507605
78	Abnormality of B cell number (HP:0010975)	1.98881219
79	Triphalangeal thumb (HP:0001199)	1.97451943
80	Type II lissencephaly (HP:0007260)	1.97164900
81	B lymphocytopenia (HP:0010976)	1.90616894
82	Congenital, generalized hypertrichosis (HP:0004540)	1.87632481
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87042264
84	Depressed nasal ridge (HP:0000457)	1.86366012
85	Limb dystonia (HP:0002451)	1.85227696
86	Abnormality of renal resorption (HP:0011038)	1.84424367
87	Type 2 muscle fiber atrophy (HP:0003554)	1.84304745
88	Chronic otitis media (HP:0000389)	1.83598915
89	Abnormality of the 4th metacarpal (HP:0010012)	1.83048380
90	Increased serum lactate (HP:0002151)	1.82589543
91	Stenosis of the external auditory canal (HP:0000402)	1.82199570
92	Attenuation of retinal blood vessels (HP:0007843)	1.80918964
93	Optic nerve hypoplasia (HP:0000609)	1.78631315
94	Hypoproteinemia (HP:0003075)	1.78588493
95	Respiratory difficulties (HP:0002880)	1.77587271
96	Hemiparesis (HP:0001269)	1.76361386
97	Postaxial hand polydactyly (HP:0001162)	1.73930692
98	Increased muscle lipid content (HP:0009058)	1.73828744
99	Optic nerve coloboma (HP:0000588)	1.72619071
100	Preaxial hand polydactyly (HP:0001177)	1.72157602

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.84811625
2	VRK2	3.13379023
3	WNK3	2.62580449
4	BCKDK	2.45576037
5	TESK2	2.39990947
6	ADRBK2	2.36926487
7	VRK1	2.29632667
8	TLK1	2.25674866
9	GRK1	2.22579884
10	MAP3K12	2.17772597
11	TAOK3	2.11770225
12	TIE1	2.11668656
13	TXK	2.09088819
14	ZAK	2.08078707
15	PASK	1.90445549
16	PINK1	1.76118569
17	MAPK15	1.71500839
18	KDR	1.65013383
19	CDK19	1.64384454
20	WNK4	1.61551319
21	IRAK1	1.50843979
22	NUAK1	1.46821293
23	BUB1	1.46213736
24	MAP3K11	1.46117488
25	PNCK	1.44266610
26	BMPR1B	1.44255880
27	DYRK2	1.44070852
28	DAPK2	1.43359803
29	MAP3K4	1.43098023
30	CASK	1.43036016
31	EPHB2	1.40643716
32	WEE1	1.28356808
33	MAPK13	1.20439207
34	TGFBR1	1.18237231
35	RPS6KA4	1.12822517
36	TSSK6	1.11326369
37	LIMK1	1.08731189
38	DYRK3	1.04066990
39	INSRR	1.01897809
40	FRK	1.01277929
41	KIT	1.00515066
42	STK16	0.97775848
43	NEK2	0.95902254
44	TNIK	0.95487572
45	NTRK3	0.93874490
46	ACVR1B	0.92381838
47	OXSR1	0.92118422
48	TAF1	0.91637063
49	STK39	0.90032278
50	FGFR2	0.87062137
51	GRK7	0.83326624
52	GRK6	0.80043219
53	SYK	0.78154657
54	CDK3	0.77518050
55	EPHA4	0.76726311
56	TAOK1	0.74277676
57	MKNK1	0.71053965
58	MAP2K4	0.69869716
59	TEC	0.69414543
60	OBSCN	0.69388078
61	TYRO3	0.68610424
62	CDK8	0.68280716
63	ITK	0.66266060
64	CCNB1	0.64889949
65	NME1	0.64785053
66	ADRBK1	0.63619989
67	UHMK1	0.59557293
68	FES	0.58913129
69	ERBB3	0.57420742
70	MUSK	0.56296383
71	PRKCG	0.56164439
72	MARK1	0.55786893
73	PRKCQ	0.55333862
74	RPS6KA5	0.55281416
75	PHKG1	0.54673258
76	PHKG2	0.54673258
77	PRKCE	0.53794972
78	PLK4	0.48560741
79	MATK	0.48435060
80	STK11	0.48025129
81	IRAK2	0.47474593
82	PRKACA	0.47092826
83	NTRK2	0.46763807
84	MINK1	0.46245958
85	TRIM28	0.44813178
86	LYN	0.44360926
87	LCK	0.43642917
88	DYRK1A	0.42323646
89	PLK3	0.40806169
90	MAPKAPK5	0.40380322
91	MAP2K6	0.40378983
92	PRKG1	0.37791341
93	CAMKK2	0.36946479
94	TNK2	0.36259323
95	CAMK2A	0.35659541
96	MAP3K5	0.34651034
97	CSNK2A1	0.31913122
98	MAP4K1	0.29442504
99	CAMKK1	0.28680241
100	SGK223	0.28392662

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.37225497
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.05620227
3	Parkinsons disease_Homo sapiens_hsa05012	3.39809878
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.93817439
5	Proteasome_Homo sapiens_hsa03050	2.48816157
6	Huntingtons disease_Homo sapiens_hsa05016	2.34220804
7	Alzheimers disease_Homo sapiens_hsa05010	2.31002162
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21880309
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.15670241
10	Caffeine metabolism_Homo sapiens_hsa00232	2.15134929
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12409730
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.04971024
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04870962
14	Protein export_Homo sapiens_hsa03060	1.90077364
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88966785
16	Nicotine addiction_Homo sapiens_hsa05033	1.87494701
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.82711509
18	Phototransduction_Homo sapiens_hsa04744	1.80079541
19	RNA polymerase_Homo sapiens_hsa03020	1.73705484
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72161160
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.71819856
22	Butanoate metabolism_Homo sapiens_hsa00650	1.67020509
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48613510
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32469498
25	Taste transduction_Homo sapiens_hsa04742	1.29098237
26	Basal transcription factors_Homo sapiens_hsa03022	1.27126971
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.19826798
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19018443
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.18435001
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.17668648
31	Olfactory transduction_Homo sapiens_hsa04740	1.15900551
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.14705899
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11518439
34	Propanoate metabolism_Homo sapiens_hsa00640	1.10929656
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.10660425
36	RNA degradation_Homo sapiens_hsa03018	1.06946337
37	GABAergic synapse_Homo sapiens_hsa04727	1.06654078
38	Morphine addiction_Homo sapiens_hsa05032	1.04703506
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.01806905
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.97955855
41	Homologous recombination_Homo sapiens_hsa03440	0.94580040
42	Purine metabolism_Homo sapiens_hsa00230	0.94186977
43	Peroxisome_Homo sapiens_hsa04146	0.92548999
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92285927
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.89967615
46	Allograft rejection_Homo sapiens_hsa05330	0.87128281
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86745509
48	Serotonergic synapse_Homo sapiens_hsa04726	0.86531202
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85996777
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84161608
51	Circadian entrainment_Homo sapiens_hsa04713	0.82948109
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82555144
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81634724
54	One carbon pool by folate_Homo sapiens_hsa00670	0.81573501
55	Asthma_Homo sapiens_hsa05310	0.81091031
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78971884
57	Retinol metabolism_Homo sapiens_hsa00830	0.77590391
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.76039810
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.73327784
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.73132198
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72681120
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68691462
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67733578
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67632888
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.64464188
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64331405
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.60389136
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59736519
69	RNA transport_Homo sapiens_hsa03013	0.58970656
70	Metabolic pathways_Homo sapiens_hsa01100	0.58863348
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.56815254
72	Spliceosome_Homo sapiens_hsa03040	0.54020234
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53882777
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48658015
75	Salivary secretion_Homo sapiens_hsa04970	0.48107428
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45493855
77	Cocaine addiction_Homo sapiens_hsa05030	0.44333655
78	Folate biosynthesis_Homo sapiens_hsa00790	0.43116188
79	Regulation of autophagy_Homo sapiens_hsa04140	0.42556961
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42345609
81	Cholinergic synapse_Homo sapiens_hsa04725	0.41838926
82	Base excision repair_Homo sapiens_hsa03410	0.41293173
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40728451
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40509266
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.39684350
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.39247688
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39228772
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36678792
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34809742
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.33655616
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32691919
92	Sulfur relay system_Homo sapiens_hsa04122	0.32504604
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.32122046
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29079304
95	Amphetamine addiction_Homo sapiens_hsa05031	0.27597028
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.27325586
97	Renin secretion_Homo sapiens_hsa04924	0.26536050
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25630002
99	Mismatch repair_Homo sapiens_hsa03430	0.24562805
100	Mineral absorption_Homo sapiens_hsa04978	0.24413287

EIF3LP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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