ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.32758350
2	translational termination (GO:0006415)	6.04295822
3	neuron fate specification (GO:0048665)	5.81994254
4	adult feeding behavior (GO:0008343)	5.47616267
5	cotranslational protein targeting to membrane (GO:0006613)	5.29847815
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.26751232
7	protein targeting to ER (GO:0045047)	5.25775813
8	protein complex biogenesis (GO:0070271)	5.22552800
9	behavioral response to nicotine (GO:0035095)	5.18369299
10	translational elongation (GO:0006414)	5.16624072
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.04454482
12	ATP synthesis coupled proton transport (GO:0015986)	5.04454482
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.96096988
14	ribosomal small subunit assembly (GO:0000028)	4.94869101
15	protein localization to endoplasmic reticulum (GO:0070972)	4.88871320
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83345403
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.65931062
18	NADH dehydrogenase complex assembly (GO:0010257)	4.65931062
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.65931062
20	cellular protein complex disassembly (GO:0043624)	4.62036361
21	mitochondrial respiratory chain complex assembly (GO:0033108)	4.60027164
22	chondrocyte proliferation (GO:0035988)	4.50149645
23	viral life cycle (GO:0019058)	4.49499632
24	translational initiation (GO:0006413)	4.45936365
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.28766878
26	positive regulation of gastrulation (GO:2000543)	4.20744362
27	chaperone-mediated protein transport (GO:0072321)	4.06131625
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.94106185
29	protein complex disassembly (GO:0043241)	3.86577719
30	respiratory electron transport chain (GO:0022904)	3.72510447
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.71496401
32	maturation of SSU-rRNA (GO:0030490)	3.67623896
33	electron transport chain (GO:0022900)	3.66970393
34	macromolecular complex disassembly (GO:0032984)	3.62045352
35	postsynaptic membrane organization (GO:0001941)	3.50752142
36	neuron maturation (GO:0042551)	3.43677962
37	protein targeting to membrane (GO:0006612)	3.40823530
38	transcription from mitochondrial promoter (GO:0006390)	3.38349096
39	ribosomal large subunit biogenesis (GO:0042273)	3.32339302
40	proton transport (GO:0015992)	3.22960522
41	protein neddylation (GO:0045116)	3.22112627
42	ribosomal small subunit biogenesis (GO:0042274)	3.21754984
43	signal peptide processing (GO:0006465)	3.17891263
44	hydrogen ion transmembrane transport (GO:1902600)	3.17101350
45	hydrogen transport (GO:0006818)	3.15553918
46	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.11990985
47	translation (GO:0006412)	3.08902965
48	regulation of feeding behavior (GO:0060259)	3.08316723
49	proteasome assembly (GO:0043248)	3.07442851
50	gamma-aminobutyric acid transport (GO:0015812)	2.98745866
51	mRNA catabolic process (GO:0006402)	2.95769103
52	DNA double-strand break processing (GO:0000729)	2.95634212
53	outer ear morphogenesis (GO:0042473)	2.93573890
54	appendage development (GO:0048736)	2.88168929
55	limb development (GO:0060173)	2.88168929
56	ovulation cycle (GO:0042698)	2.84560728
57	primitive streak formation (GO:0090009)	2.82352544
58	cullin deneddylation (GO:0010388)	2.81349169
59	GPI anchor metabolic process (GO:0006505)	2.80106222
60	sequestering of actin monomers (GO:0042989)	2.79183720
61	vitamin A metabolic process (GO:0006776)	2.79102328
62	head development (GO:0060322)	2.78403658
63	DNA damage response, detection of DNA damage (GO:0042769)	2.78325386
64	glomerulus development (GO:0032835)	2.74859536
65	RNA destabilization (GO:0050779)	2.74162250
66	protein-cofactor linkage (GO:0018065)	2.74073351
67	positive regulation of developmental pigmentation (GO:0048087)	2.72828421
68	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.69638814
69	platelet dense granule organization (GO:0060155)	2.69375900
70	dendritic spine morphogenesis (GO:0060997)	2.68867579
71	pyrimidine nucleobase catabolic process (GO:0006208)	2.67551616
72	cellular response to leptin stimulus (GO:0044320)	2.65886260
73	protein deneddylation (GO:0000338)	2.62427585
74	regulation of phospholipid biosynthetic process (GO:0071071)	2.62272472
75	7-methylguanosine mRNA capping (GO:0006370)	2.61891919
76	urogenital system development (GO:0001655)	2.61126346
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58302012
78	mitochondrial calcium ion transport (GO:0006851)	2.58095262
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57842318
80	termination of RNA polymerase III transcription (GO:0006386)	2.57842318
81	RNA catabolic process (GO:0006401)	2.57542696
82	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.56616024
83	7-methylguanosine RNA capping (GO:0009452)	2.56187544
84	RNA capping (GO:0036260)	2.56187544
85	presynaptic membrane assembly (GO:0097105)	2.54600035
86	regulation of action potential (GO:0098900)	2.54501680
87	neural tube formation (GO:0001841)	2.53661047
88	water-soluble vitamin biosynthetic process (GO:0042364)	2.52251523
89	ATP biosynthetic process (GO:0006754)	2.51676737
90	mitochondrial RNA metabolic process (GO:0000959)	2.50195934
91	alkaloid metabolic process (GO:0009820)	2.50021921
92	olfactory bulb development (GO:0021772)	2.49088194
93	GMP metabolic process (GO:0046037)	2.48686771
94	regulation of pigment cell differentiation (GO:0050932)	2.47752737
95	CENP-A containing nucleosome assembly (GO:0034080)	2.45243694
96	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.44691014
97	spliceosomal snRNP assembly (GO:0000387)	2.41916782
98	retina layer formation (GO:0010842)	2.41602823
99	regulation of collateral sprouting (GO:0048670)	2.40365617
100	chromatin remodeling at centromere (GO:0031055)	2.39725080

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.29101875
2	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.41996110
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30664440
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.99342913
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94687940
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.93201903
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.88509250
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.88486361
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.74310959
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.57063022
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51203368
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.32841722
13	VDR_22108803_ChIP-Seq_LS180_Human	2.28279636
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.27948044
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.24419010
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19120339
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.12474684
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12309240
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.03793555
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03163148
21	FUS_26573619_Chip-Seq_HEK293_Human	1.98530752
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95970309
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94736041
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91030582
25	EWS_26573619_Chip-Seq_HEK293_Human	1.90970432
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90124354
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87300675
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.84334621
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.83240047
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.75752788
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75739911
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.68844956
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.64390351
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61606578
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.58815224
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.58356586
37	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.57104654
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56944985
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55484680
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55016208
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54779494
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.54377398
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53889864
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43657272
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42551333
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.41647827
47	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39207714
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36643190
49	P300_19829295_ChIP-Seq_ESCs_Human	1.31780226
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29667137
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.29557046
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29205191
53	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.28406418
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26942502
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26942502
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25492258
57	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25191271
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24086811
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20738886
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.20101892
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16875059
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13299533
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12931741
64	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11081929
65	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10555794
66	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10228433
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08912314
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08043071
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06169850
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02799352
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.02292836
72	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.02075460
73	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.02075460
74	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.01033471
75	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.00543351
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00391176
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00299385
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00224419
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99597189
80	GBX2_23144817_ChIP-Seq_PC3_Human	0.99301631
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98191468
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98149798
83	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97644712
84	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.96128544
85	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95929412
86	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95695987
87	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95220886
88	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94693893
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93994023
90	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.92916896
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92874022
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92838592
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92229905
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.92229905
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.92209241
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91008140
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91008140
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90144275
99	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89478151
100	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89346957

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.68234815
2	MP0009379_abnormal_foot_pigmentation	3.96496244
3	MP0003880_abnormal_central_pattern	3.77698265
4	MP0002938_white_spotting	3.11874071
5	MP0000566_synostosis	3.06197880
6	MP0000569_abnormal_digit_pigmentation	2.78458904
7	MP0001529_abnormal_vocalization	2.55521122
8	MP0003315_abnormal_perineum_morphology	2.36834732
9	MP0005187_abnormal_penis_morphology	2.20815332
10	MP0000372_irregular_coat_pigmentation	2.19217768
11	MP0004133_heterotaxia	2.18340093
12	MP0001293_anophthalmia	2.12668906
13	MP0003890_abnormal_embryonic-extraembry	2.00276965
14	MP0006276_abnormal_autonomic_nervous	2.00241825
15	MP0004142_abnormal_muscle_tone	1.90874380
16	MP0002095_abnormal_skin_pigmentation	1.89847477
17	MP0008995_early_reproductive_senescence	1.85671064
18	MP0003646_muscle_fatigue	1.84246057
19	MP0002234_abnormal_pharynx_morphology	1.78717386
20	MP0006072_abnormal_retinal_apoptosis	1.76241087
21	MP0002272_abnormal_nervous_system	1.73665140
22	MP0004742_abnormal_vestibular_system	1.70379539
23	MP0004145_abnormal_muscle_electrophysio	1.70278486
24	MP0005646_abnormal_pituitary_gland	1.67184182
25	MP0002557_abnormal_social/conspecific_i	1.65600030
26	MP0003011_delayed_dark_adaptation	1.60041453
27	MP0003718_maternal_effect	1.57945632
28	MP0005075_abnormal_melanosome_morpholog	1.53015477
29	MP0002277_abnormal_respiratory_mucosa	1.51369047
30	MP0004885_abnormal_endolymph	1.49993507
31	MP0002928_abnormal_bile_duct	1.48459912
32	MP0002572_abnormal_emotion/affect_behav	1.48097535
33	MP0005174_abnormal_tail_pigmentation	1.47839631
34	MP0002184_abnormal_innervation	1.46352059
35	MP0001485_abnormal_pinna_reflex	1.44110468
36	MP0005084_abnormal_gallbladder_morpholo	1.44023088
37	MP0003959_abnormal_lean_body	1.40449539
38	MP0005253_abnormal_eye_physiology	1.39132453
39	MP0005367_renal/urinary_system_phenotyp	1.37422951
40	MP0000516_abnormal_urinary_system	1.37422951
41	MP0003937_abnormal_limbs/digits/tail_de	1.35079422
42	MP0005551_abnormal_eye_electrophysiolog	1.33978466
43	MP0001346_abnormal_lacrimal_gland	1.33869981
44	MP0005503_abnormal_tendon_morphology	1.33845383
45	MP0000631_abnormal_neuroendocrine_gland	1.29292577
46	MP0000647_abnormal_sebaceous_gland	1.24569909
47	MP0002736_abnormal_nociception_after	1.23301186
48	MP0003567_abnormal_fetal_cardiomyocyte	1.22636607
49	MP0005386_behavior/neurological_phenoty	1.19691069
50	MP0004924_abnormal_behavior	1.19691069
51	MP0002735_abnormal_chemical_nociception	1.18941065
52	MP0000778_abnormal_nervous_system	1.18708749
53	MP0000049_abnormal_middle_ear	1.18611014
54	MP0005171_absent_coat_pigmentation	1.18590405
55	MP0000537_abnormal_urethra_morphology	1.15998256
56	MP0001968_abnormal_touch/_nociception	1.14237908
57	MP0001905_abnormal_dopamine_level	1.14040282
58	MP0006292_abnormal_olfactory_placode	1.13665293
59	MP0002102_abnormal_ear_morphology	1.12127471
60	MP0003119_abnormal_digestive_system	1.11281712
61	MP0001486_abnormal_startle_reflex	1.11043304
62	MP0003283_abnormal_digestive_organ	1.10973968
63	MP0003122_maternal_imprinting	1.09748944
64	MP0002163_abnormal_gland_morphology	1.09185840
65	MP0009745_abnormal_behavioral_response	1.07446054
66	MP0003942_abnormal_urinary_system	1.06857012
67	MP0001984_abnormal_olfaction	1.06295377
68	MP0000026_abnormal_inner_ear	1.05912399
69	MP0008789_abnormal_olfactory_epithelium	1.04110831
70	MP0001440_abnormal_grooming_behavior	1.03930166
71	MP0002064_seizures	1.03730393
72	MP0005423_abnormal_somatic_nervous	1.02773134
73	MP0002653_abnormal_ependyma_morphology	1.02535941
74	MP0005167_abnormal_blood-brain_barrier	1.01944695
75	MP0003252_abnormal_bile_duct	1.01928961
76	MP0003635_abnormal_synaptic_transmissio	0.97684838
77	MP0002638_abnormal_pupillary_reflex	0.96016614
78	MP0009053_abnormal_anal_canal	0.92172075
79	MP0004381_abnormal_hair_follicle	0.91270185
80	MP0008872_abnormal_physiological_respon	0.89809166
81	MP0002751_abnormal_autonomic_nervous	0.89122979
82	MP0005391_vision/eye_phenotype	0.85571524
83	MP0002822_catalepsy	0.82795208
84	MP0002063_abnormal_learning/memory/cond	0.80915195
85	MP0001970_abnormal_pain_threshold	0.80667694
86	MP0002733_abnormal_thermal_nociception	0.75311320
87	MP0002882_abnormal_neuron_morphology	0.75014178
88	MP0009250_abnormal_appendicular_skeleto	0.74096343
89	MP0000534_abnormal_ureter_morphology	0.73618711
90	MP0002067_abnormal_sensory_capabilities	0.73551955
91	MP0002752_abnormal_somatic_nervous	0.71919356
92	MP0002837_dystrophic_cardiac_calcinosis	0.71118884
93	MP0005535_abnormal_body_temperature	0.70923855
94	MP0010368_abnormal_lymphatic_system	0.70884340
95	MP0005394_taste/olfaction_phenotype	0.70561423
96	MP0005499_abnormal_olfactory_system	0.70561423
97	MP0001324_abnormal_eye_pigmentation	0.70255703
98	MP0003786_premature_aging	0.67782809
99	MP0003861_abnormal_nervous_system	0.67761000
100	MP0010030_abnormal_orbit_morphology	0.67587264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.21318683
2	Reticulocytopenia (HP:0001896)	4.01933593
3	Pancreatic cysts (HP:0001737)	3.78750255
4	3-Methylglutaconic aciduria (HP:0003535)	3.78285830
5	Pancreatic fibrosis (HP:0100732)	3.70105840
6	Abolished electroretinogram (ERG) (HP:0000550)	3.67040329
7	Molar tooth sign on MRI (HP:0002419)	3.62014428
8	Abnormality of midbrain morphology (HP:0002418)	3.62014428
9	Lipid accumulation in hepatocytes (HP:0006561)	3.48926760
10	Nephronophthisis (HP:0000090)	3.45972588
11	Attenuation of retinal blood vessels (HP:0007843)	3.06209411
12	True hermaphroditism (HP:0010459)	3.01516441
13	Renal Fanconi syndrome (HP:0001994)	3.00166876
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97432297
15	Mitochondrial inheritance (HP:0001427)	2.96515869
16	Partial duplication of thumb phalanx (HP:0009944)	2.96009582
17	Partial duplication of the phalanx of hand (HP:0009999)	2.95611414
18	Optic disc pallor (HP:0000543)	2.95369966
19	Microvesicular hepatic steatosis (HP:0001414)	2.90066022
20	Macrocytic anemia (HP:0001972)	2.83153500
21	Increased intramyocellular lipid droplets (HP:0012240)	2.81063731
22	Acute necrotizing encephalopathy (HP:0006965)	2.79826458
23	Medial flaring of the eyebrow (HP:0010747)	2.75975752
24	Abnormal number of erythroid precursors (HP:0012131)	2.74390291
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.72271066
26	Abnormality of the renal medulla (HP:0100957)	2.67774383
27	Congenital stationary night blindness (HP:0007642)	2.67416924
28	Hypoplasia of the pons (HP:0012110)	2.62844360
29	Type II lissencephaly (HP:0007260)	2.58477812
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.57409471
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.57409471
32	Aplastic anemia (HP:0001915)	2.54961862
33	Increased CSF lactate (HP:0002490)	2.54284578
34	Congenital, generalized hypertrichosis (HP:0004540)	2.53516328
35	Chronic hepatic failure (HP:0100626)	2.48717569
36	Bony spicule pigmentary retinopathy (HP:0007737)	2.47942965
37	Hyperinsulinemic hypoglycemia (HP:0000825)	2.44314939
38	Stenosis of the external auditory canal (HP:0000402)	2.43049070
39	Progressive macrocephaly (HP:0004481)	2.40907189
40	Pendular nystagmus (HP:0012043)	2.39020960
41	Abnormality of the pons (HP:0007361)	2.38375625
42	Exertional dyspnea (HP:0002875)	2.36222267
43	Inability to walk (HP:0002540)	2.36135457
44	Pheochromocytoma (HP:0002666)	2.35334594
45	Intestinal atresia (HP:0011100)	2.34859479
46	Bile duct proliferation (HP:0001408)	2.34739840
47	Abnormal biliary tract physiology (HP:0012439)	2.34739840
48	Duplication of thumb phalanx (HP:0009942)	2.34596504
49	Acute encephalopathy (HP:0006846)	2.32103889
50	Abnormality of the parietal bone (HP:0002696)	2.32096932
51	Colon cancer (HP:0003003)	2.25548208
52	Patellar aplasia (HP:0006443)	2.23747409
53	Hepatocellular necrosis (HP:0001404)	2.20981802
54	Oligodactyly (hands) (HP:0001180)	2.18461658
55	Methylmalonic acidemia (HP:0002912)	2.17990542
56	Agitation (HP:0000713)	2.17911079
57	Genital tract atresia (HP:0001827)	2.12926665
58	Limb dystonia (HP:0002451)	2.10389634
59	Decreased central vision (HP:0007663)	2.10328563
60	Occipital encephalocele (HP:0002085)	2.09854641
61	Aplasia/Hypoplasia of the patella (HP:0006498)	2.04769951
62	Neuroendocrine neoplasm (HP:0100634)	2.04742961
63	Increased muscle lipid content (HP:0009058)	2.02218202
64	Septo-optic dysplasia (HP:0100842)	2.01731753
65	Duplicated collecting system (HP:0000081)	2.01353651
66	Pallor (HP:0000980)	2.00444751
67	Hyperventilation (HP:0002883)	2.00102830
68	Furrowed tongue (HP:0000221)	2.00065896
69	Abnormality of renal resorption (HP:0011038)	1.99663338
70	Abnormality of alanine metabolism (HP:0010916)	1.99383345
71	Hyperalaninemia (HP:0003348)	1.99383345
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.99383345
73	Abnormality of the renal collecting system (HP:0004742)	1.99293819
74	Gait imbalance (HP:0002141)	1.98420726
75	Split foot (HP:0001839)	1.97771222
76	Anencephaly (HP:0002323)	1.96490690
77	Short 4th metacarpal (HP:0010044)	1.94482573
78	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.94482573
79	Increased serum lactate (HP:0002151)	1.94364805
80	Vaginal atresia (HP:0000148)	1.94137091
81	Glycosuria (HP:0003076)	1.93453005
82	Abnormality of urine glucose concentration (HP:0011016)	1.93453005
83	Nephrogenic diabetes insipidus (HP:0009806)	1.91632722
84	Congenital primary aphakia (HP:0007707)	1.88809745
85	Recurrent corneal erosions (HP:0000495)	1.88019759
86	Polydipsia (HP:0001959)	1.86871760
87	Abnormal drinking behavior (HP:0030082)	1.86871760
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86264341
89	Ketoacidosis (HP:0001993)	1.85688272
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85099918
91	Postaxial foot polydactyly (HP:0001830)	1.83900320
92	Macular degeneration (HP:0000608)	1.83723001
93	Hypoglycemic seizures (HP:0002173)	1.83165363
94	Morphological abnormality of the middle ear (HP:0008609)	1.82298023
95	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.81708061
96	Concave nail (HP:0001598)	1.80124698
97	Hepatic necrosis (HP:0002605)	1.78090185
98	Cerebellar dysplasia (HP:0007033)	1.77333730
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76353135
100	Male pseudohermaphroditism (HP:0000037)	1.75365701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.52632541
2	TAF1	3.50957509
3	VRK2	3.02050976
4	BMPR1B	2.82936196
5	CDK8	2.82501781
6	NUAK1	2.81983252
7	TXK	2.67775969
8	WNK3	2.57903848
9	TNIK	2.56759534
10	BUB1	2.56454776
11	ADRBK2	2.39527140
12	GRK1	2.33272162
13	PASK	2.09134836
14	TGFBR1	1.81570754
15	FRK	1.78831587
16	MARK1	1.74422699
17	STK16	1.71302289
18	VRK1	1.69668801
19	NEK1	1.64727371
20	DYRK2	1.63687313
21	ACVR1B	1.58907812
22	ZAK	1.52209657
23	WNK4	1.46720883
24	MKNK2	1.45008271
25	TEC	1.42095463
26	TRIM28	1.40950509
27	MAP4K2	1.40184468
28	PBK	1.39639515
29	INSRR	1.36659505
30	PAK3	1.23288008
31	NME1	1.22585885
32	MKNK1	1.21293907
33	TSSK6	1.19062726
34	WEE1	1.17766356
35	EPHB2	1.16966700
36	MAPK13	1.10611790
37	DYRK3	1.09105362
38	OXSR1	1.02837247
39	ADRBK1	1.01730801
40	BCR	1.01608884
41	TLK1	1.00115115
42	FGFR2	0.99413326
43	STK39	0.98517059
44	PNCK	0.97226283
45	PRKCG	0.95888745
46	PHKG2	0.91243251
47	PHKG1	0.91243251
48	CASK	0.89779503
49	SRPK1	0.85548749
50	PLK3	0.83500878
51	CSNK1G2	0.82681883
52	GRK5	0.82577604
53	MAPKAPK5	0.81575248
54	MAP3K4	0.79063912
55	BCKDK	0.78766603
56	RPS6KA5	0.72981095
57	EIF2AK3	0.69362615
58	DYRK1A	0.68712651
59	MAP2K6	0.67471352
60	MUSK	0.65043204
61	MINK1	0.64510321
62	CHEK2	0.58395367
63	DAPK2	0.56970800
64	PINK1	0.56065862
65	TAOK3	0.55103104
66	UHMK1	0.53217890
67	PLK2	0.49662137
68	PRKACA	0.48253725
69	ATR	0.48186974
70	PLK4	0.46056310
71	MAPK15	0.44119435
72	DAPK3	0.42510137
73	CAMK2A	0.42395299
74	PTK2B	0.40774979
75	PRKCE	0.39830227
76	EIF2AK2	0.39540335
77	CAMK1	0.39051819
78	CSNK1A1	0.38492369
79	MAP2K4	0.38147691
80	OBSCN	0.37487093
81	CSNK1G3	0.36539438
82	CDK7	0.36205119
83	BLK	0.35315076
84	AURKA	0.35295564
85	CSNK2A2	0.34922009
86	PKN1	0.34559162
87	PRKCZ	0.34288298
88	CSNK1G1	0.33829989
89	ERBB2	0.33322647
90	CDK19	0.32779777
91	MAP2K7	0.32722966
92	STK3	0.32549356
93	STK11	0.32041495
94	LRRK2	0.31618325
95	FGFR1	0.31333566
96	AURKB	0.30920538
97	PRKCH	0.30644349
98	CSNK2A1	0.29867666
99	DYRK1B	0.29523662
100	NTRK2	0.28497778

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.27746859
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.42557518
3	Parkinsons disease_Homo sapiens_hsa05012	3.76667513
4	RNA polymerase_Homo sapiens_hsa03020	3.39834968
5	Protein export_Homo sapiens_hsa03060	3.28845094
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.19122825
7	Proteasome_Homo sapiens_hsa03050	2.91655770
8	Huntingtons disease_Homo sapiens_hsa05016	2.61535089
9	Alzheimers disease_Homo sapiens_hsa05010	2.41938126
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.19270505
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07339725
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01819587
13	Nicotine addiction_Homo sapiens_hsa05033	1.95774725
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.94579388
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75398364
16	Caffeine metabolism_Homo sapiens_hsa00232	1.70740802
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64934937
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.57500670
19	Homologous recombination_Homo sapiens_hsa03440	1.54888264
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54723385
21	Sulfur relay system_Homo sapiens_hsa04122	1.51499610
22	Phototransduction_Homo sapiens_hsa04744	1.50702527
23	RNA degradation_Homo sapiens_hsa03018	1.26236371
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18804294
25	Spliceosome_Homo sapiens_hsa03040	1.15647886
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15290641
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12795274
28	Purine metabolism_Homo sapiens_hsa00230	1.10986308
29	Basal transcription factors_Homo sapiens_hsa03022	1.07108909
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06564684
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.05326319
32	Glutathione metabolism_Homo sapiens_hsa00480	1.04438191
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02584442
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01800768
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.01370354
36	RNA transport_Homo sapiens_hsa03013	1.01076394
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98597845
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.98565259
39	Regulation of autophagy_Homo sapiens_hsa04140	0.94643577
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92837517
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.89378561
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.87288789
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86473070
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82941762
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82318461
46	Mismatch repair_Homo sapiens_hsa03430	0.81497184
47	Butanoate metabolism_Homo sapiens_hsa00650	0.80984825
48	Folate biosynthesis_Homo sapiens_hsa00790	0.76888465
49	Peroxisome_Homo sapiens_hsa04146	0.76848344
50	GABAergic synapse_Homo sapiens_hsa04727	0.76825483
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75901841
52	Sulfur metabolism_Homo sapiens_hsa00920	0.75811564
53	Taste transduction_Homo sapiens_hsa04742	0.72359716
54	Morphine addiction_Homo sapiens_hsa05032	0.71248637
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71070152
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.70481784
57	Propanoate metabolism_Homo sapiens_hsa00640	0.70454027
58	Cocaine addiction_Homo sapiens_hsa05030	0.69103408
59	Serotonergic synapse_Homo sapiens_hsa04726	0.67551669
60	Metabolic pathways_Homo sapiens_hsa01100	0.65349035
61	Olfactory transduction_Homo sapiens_hsa04740	0.65280377
62	Mineral absorption_Homo sapiens_hsa04978	0.64490770
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63488973
64	Insulin secretion_Homo sapiens_hsa04911	0.60570007
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58434303
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56848062
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.55121109
68	Retinol metabolism_Homo sapiens_hsa00830	0.54724310
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54601151
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53982696
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.53547656
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.53491254
73	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.53369965
74	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51407620
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.48127336
76	Amphetamine addiction_Homo sapiens_hsa05031	0.46695644
77	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42971878
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41010441
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39017412
80	DNA replication_Homo sapiens_hsa03030	0.38998435
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38876861
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.36931566
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33326610
84	Tryptophan metabolism_Homo sapiens_hsa00380	0.32685943
85	One carbon pool by folate_Homo sapiens_hsa00670	0.31827842
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31534731
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31113415
88	p53 signaling pathway_Homo sapiens_hsa04115	0.26659608
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.25565188
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25350415
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25125482
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24092810
93	Axon guidance_Homo sapiens_hsa04360	0.22939636
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.22443217
95	Asthma_Homo sapiens_hsa05310	0.21200737
96	Circadian entrainment_Homo sapiens_hsa04713	0.20082691
97	ABC transporters_Homo sapiens_hsa02010	0.19735950
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18090857
99	Type I diabetes mellitus_Homo sapiens_hsa04940	0.17629887
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.17005239

EIF3LP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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