EIF3M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23122873
2* formation of translation preinitiation complex (GO:0001731)4.93804649
3ribosomal small subunit assembly (GO:0000028)4.93188780
4viral transcription (GO:0019083)4.77239985
5translational termination (GO:0006415)4.68550916
6maturation of SSU-rRNA (GO:0030490)4.64852673
7telomere maintenance via semi-conservative replication (GO:0032201)4.55259180
8DNA strand elongation involved in DNA replication (GO:0006271)4.49461566
9ribosomal small subunit biogenesis (GO:0042274)4.31499404
10DNA strand elongation (GO:0022616)4.29692941
11translational elongation (GO:0006414)4.26724863
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.20147314
13* translational initiation (GO:0006413)4.19726986
14viral mRNA export from host cell nucleus (GO:0046784)4.19083687
15cotranslational protein targeting to membrane (GO:0006613)4.12734096
16ribosomal large subunit biogenesis (GO:0042273)4.10204741
17protein targeting to ER (GO:0045047)4.09417327
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08154485
19telomere maintenance via recombination (GO:0000722)4.02628587
20proline biosynthetic process (GO:0006561)3.96218990
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91369253
22proteasome assembly (GO:0043248)3.90598377
23establishment of protein localization to endoplasmic reticulum (GO:0072599)3.88926269
24ribonucleoprotein complex biogenesis (GO:0022613)3.88897533
25protein localization to endoplasmic reticulum (GO:0070972)3.86141056
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.82201909
27nucleobase biosynthetic process (GO:0046112)3.72750748
28viral life cycle (GO:0019058)3.72526821
29ribosome biogenesis (GO:0042254)3.71889454
30DNA replication initiation (GO:0006270)3.71454259
31cullin deneddylation (GO:0010388)3.70086952
32mitotic recombination (GO:0006312)3.69893703
33replication fork processing (GO:0031297)3.68865703
34cellular protein complex disassembly (GO:0043624)3.66844738
35rRNA processing (GO:0006364)3.60672424
36transcription from mitochondrial promoter (GO:0006390)3.60014100
37chaperone-mediated protein transport (GO:0072321)3.59680051
38DNA double-strand break processing (GO:0000729)3.59142553
39telomere maintenance via telomere lengthening (GO:0010833)3.55256038
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.55194538
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.55194538
42purine nucleobase biosynthetic process (GO:0009113)3.54819785
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.51938316
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51774430
45IMP metabolic process (GO:0046040)3.51620255
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.50167778
47nuclear pore complex assembly (GO:0051292)3.48798885
48* translation (GO:0006412)3.47730304
49rRNA metabolic process (GO:0016072)3.46716235
50DNA unwinding involved in DNA replication (GO:0006268)3.46514217
51histone exchange (GO:0043486)3.46309636
52protein deneddylation (GO:0000338)3.44847011
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43213172
54ATP synthesis coupled proton transport (GO:0015986)3.43213172
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42504872
56spliceosomal snRNP assembly (GO:0000387)3.42240007
57mitotic sister chromatid segregation (GO:0000070)3.40995998
58mitotic spindle checkpoint (GO:0071174)3.40079137
59establishment of viral latency (GO:0019043)3.39340702
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.38898059
61maturation of 5.8S rRNA (GO:0000460)3.38639462
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.38608429
63negative regulation of sister chromatid segregation (GO:0033046)3.38608429
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38608429
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38608429
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38608429
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36683032
68ribosome assembly (GO:0042255)3.34287540
69kinetochore organization (GO:0051383)3.34080616
70spindle checkpoint (GO:0031577)3.33959549
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33958558
72transcription-coupled nucleotide-excision repair (GO:0006283)3.33529246
73negative regulation of chromosome segregation (GO:0051985)3.33346717
74DNA catabolic process, exonucleolytic (GO:0000738)3.29702776
75DNA replication-independent nucleosome organization (GO:0034724)3.29423745
76DNA replication-independent nucleosome assembly (GO:0006336)3.29423745
77kinetochore assembly (GO:0051382)3.28612803
78protein complex disassembly (GO:0043241)3.28313287
79pseudouridine synthesis (GO:0001522)3.27875310
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25096315
81mitotic metaphase plate congression (GO:0007080)3.24031111
82nuclear pore organization (GO:0006999)3.23869996
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23314174
84negative regulation of ligase activity (GO:0051352)3.23314174
85mitotic spindle assembly checkpoint (GO:0007094)3.22858739
86DNA replication checkpoint (GO:0000076)3.22813983
87sister chromatid segregation (GO:0000819)3.22722991
88nuclear-transcribed mRNA catabolic process (GO:0000956)3.21798605
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21329930
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21329930
91metaphase plate congression (GO:0051310)3.20600616
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18415955
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18415955
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18415955
95spindle assembly checkpoint (GO:0071173)3.17580035
96DNA ligation (GO:0006266)3.16535062
97termination of RNA polymerase II transcription (GO:0006369)3.14770161
98mitotic nuclear envelope disassembly (GO:0007077)3.14063828
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.14006334
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14006334
101DNA replication-dependent nucleosome organization (GO:0034723)3.12865666
102DNA replication-dependent nucleosome assembly (GO:0006335)3.12865666
103regulation of cellular amino acid metabolic process (GO:0006521)3.11733194
104double-strand break repair via nonhomologous end joining (GO:0006303)3.11533989
105non-recombinational repair (GO:0000726)3.11533989
106oxidative phosphorylation (GO:0006119)3.11400658
107macromolecular complex disassembly (GO:0032984)3.11328740
108establishment of integrated proviral latency (GO:0075713)3.10700376
109regulation of ubiquitin-protein transferase activity (GO:0051438)3.10174200
110CENP-A containing nucleosome assembly (GO:0034080)3.09800251
111tRNA aminoacylation for protein translation (GO:0006418)3.09518098
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.09007508
113regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08452605
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08452605
115tRNA aminoacylation (GO:0043039)3.08228623
116amino acid activation (GO:0043038)3.08228623
117cell cycle G1/S phase transition (GO:0044843)3.07378420
118G1/S transition of mitotic cell cycle (GO:0000082)3.07378420
119IMP biosynthetic process (GO:0006188)3.04899066
120mRNA catabolic process (GO:0006402)3.04337136
121cellular component biogenesis (GO:0044085)3.03641077
122chromatin remodeling at centromere (GO:0031055)3.02588301
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01992710
124regulation of double-strand break repair via homologous recombination (GO:0010569)3.00416169
125base-excision repair (GO:0006284)2.97707240
126RNA catabolic process (GO:0006401)2.97622636
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96153658
128termination of RNA polymerase III transcription (GO:0006386)2.95708014
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.95708014
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92019898
131rRNA modification (GO:0000154)2.89859976
132DNA-templated transcription, termination (GO:0006353)2.89430694
133protein localization to kinetochore (GO:0034501)2.88387793
134negative regulation of RNA splicing (GO:0033119)2.88116908
135positive regulation of ligase activity (GO:0051351)2.87483744
136membrane disassembly (GO:0030397)2.86944654
137nuclear envelope disassembly (GO:0051081)2.86944654
138folic acid-containing compound biosynthetic process (GO:0009396)2.85474607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19073737
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.66958169
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83701344
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43607656
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.39191407
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.29931970
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.29714702
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17973480
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.11502341
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08233126
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03037759
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99166414
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75480701
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68017720
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67966477
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63993374
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.63361580
18VDR_23849224_ChIP-Seq_CD4+_Human2.45676022
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45083495
20XRN2_22483619_ChIP-Seq_HELA_Human2.40738063
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31484282
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28314865
23DCP1A_22483619_ChIP-Seq_HELA_Human2.25681700
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15140171
25* GABP_19822575_ChIP-Seq_HepG2_Human2.05731867
26FOXP3_21729870_ChIP-Seq_TREG_Human2.03795299
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02973469
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02761305
29TTF2_22483619_ChIP-Seq_HELA_Human2.00907700
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97184258
31ELK1_19687146_ChIP-ChIP_HELA_Human1.92816196
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90123339
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87471184
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82263792
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78024682
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.76354229
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74076181
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71079476
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70840368
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70702677
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70655275
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.70026687
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67297703
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67205127
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65029128
46AR_21909140_ChIP-Seq_LNCAP_Human1.63601399
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.63426507
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59046681
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58209453
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53935327
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.49072169
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47694490
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43141224
54KDM5A_27292631_Chip-Seq_BREAST_Human1.40719128
55EWS_26573619_Chip-Seq_HEK293_Human1.38791051
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38677584
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37745394
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35641452
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32557336
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32119723
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29889311
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28117808
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24978660
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24965633
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24828642
66MYC_22102868_ChIP-Seq_BL_Human1.24531572
67TFEB_21752829_ChIP-Seq_HELA_Human1.23003398
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22286213
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21583138
70CIITA_25753668_ChIP-Seq_RAJI_Human1.21569192
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20836605
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20434469
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18431479
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18431479
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18431479
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17049835
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17042694
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15534361
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14422194
80FUS_26573619_Chip-Seq_HEK293_Human1.13302517
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13011008
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12313501
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.11634166
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11475321
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10424629
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.09658054
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09414450
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08807683
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.07845217
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.07481700
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06200805
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05155111
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00296957
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.00163187
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.99419364
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99107433
97VDR_22108803_ChIP-Seq_LS180_Human0.97594638
98VDR_21846776_ChIP-Seq_THP-1_Human0.96053348
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94591676
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94361198
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.93739936
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.93697698
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.92774962
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91384729
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89673041
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89668504
107* SPI1_23547873_ChIP-Seq_NB4_Human0.89412750
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89285570
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88559346
110MYC_18940864_ChIP-ChIP_HL60_Human0.88101233
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87169532
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86798200
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86416060
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84258533
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83717418
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78806172
117ZNF274_21170338_ChIP-Seq_K562_Hela0.77809039
118IGF1R_20145208_ChIP-Seq_DFB_Human0.77301663
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76905531
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71161356
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70793714
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70206113
123ELF5_23300383_ChIP-Seq_T47D_Human0.68453558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86161195
2MP0008057_abnormal_DNA_replication4.84261133
3MP0004957_abnormal_blastocyst_morpholog4.37548597
4MP0010094_abnormal_chromosome_stability4.19782361
5MP0003111_abnormal_nucleus_morphology3.57835834
6MP0003077_abnormal_cell_cycle3.51560410
7MP0008058_abnormal_DNA_repair3.32547208
8MP0008932_abnormal_embryonic_tissue2.70581598
9MP0009697_abnormal_copulation2.70333007
10MP0003786_premature_aging2.48027337
11MP0008007_abnormal_cellular_replicative2.43636049
12MP0010030_abnormal_orbit_morphology2.25633313
13MP0002396_abnormal_hematopoietic_system2.13653781
14MP0001730_embryonic_growth_arrest1.99297463
15MP0000372_irregular_coat_pigmentation1.96799992
16MP0000350_abnormal_cell_proliferation1.94654564
17MP0006035_abnormal_mitochondrial_morpho1.92888841
18MP0003806_abnormal_nucleotide_metabolis1.91185216
19MP0008877_abnormal_DNA_methylation1.87306739
20MP0010352_gastrointestinal_tract_polyps1.84633734
21MP0000490_abnormal_crypts_of1.81164767
22MP0003123_paternal_imprinting1.74710033
23MP0001697_abnormal_embryo_size1.71432207
24MP0003567_abnormal_fetal_cardiomyocyte1.64699056
25MP0003890_abnormal_embryonic-extraembry1.56408337
26MP0009333_abnormal_splenocyte_physiolog1.53864576
27MP0003718_maternal_effect1.53670135
28MP0001672_abnormal_embryogenesis/_devel1.49693267
29MP0005380_embryogenesis_phenotype1.49693267
30MP0004147_increased_porphyrin_level1.47463142
31MP0001293_anophthalmia1.47299485
32MP0002080_prenatal_lethality1.45427528
33MP0001545_abnormal_hematopoietic_system1.44256559
34MP0005397_hematopoietic_system_phenotyp1.44256559
35MP0002019_abnormal_tumor_incidence1.41772341
36MP0002085_abnormal_embryonic_tissue1.40751928
37MP0003763_abnormal_thymus_physiology1.40562446
38MP0004133_heterotaxia1.38728104
39MP0002084_abnormal_developmental_patter1.38427799
40MP0000313_abnormal_cell_death1.36800826
41MP0002009_preneoplasia1.36726129
42MP0002086_abnormal_extraembryonic_tissu1.33065501
43MP0002234_abnormal_pharynx_morphology1.32030255
44MP0005408_hypopigmentation1.30121586
45MP0004197_abnormal_fetal_growth/weight/1.29010859
46MP0003984_embryonic_growth_retardation1.27805907
47MP0002102_abnormal_ear_morphology1.24605298
48MP0005075_abnormal_melanosome_morpholog1.24095903
49MP0002088_abnormal_embryonic_growth/wei1.23459724
50MP0003186_abnormal_redox_activity1.21511727
51MP0001529_abnormal_vocalization1.21109714
52MP0006072_abnormal_retinal_apoptosis1.17967673
53MP0003656_abnormal_erythrocyte_physiolo1.17532526
54MP0005171_absent_coat_pigmentation1.15529229
55MP0010307_abnormal_tumor_latency1.13058723
56MP0009379_abnormal_foot_pigmentation1.12873148
57MP0003937_abnormal_limbs/digits/tail_de1.11844494
58MP0009278_abnormal_bone_marrow1.11610310
59MP0008995_early_reproductive_senescence1.10441100
60MP0002132_abnormal_respiratory_system1.10156882
61MP0003119_abnormal_digestive_system1.09103548
62MP0002938_white_spotting1.01042997
63MP0000689_abnormal_spleen_morphology1.00944330
64MP0008961_abnormal_basal_metabolism0.96969285
65MP0000703_abnormal_thymus_morphology0.96761168
66MP0002398_abnormal_bone_marrow0.96678796
67MP0004808_abnormal_hematopoietic_stem0.96373240
68MP0002210_abnormal_sex_determination0.96037927
69MP0001145_abnormal_male_reproductive0.95930380
70MP0001764_abnormal_homeostasis0.95783689
71MP0004782_abnormal_surfactant_physiolog0.95639667
72MP0002722_abnormal_immune_system0.94447113
73MP0008789_abnormal_olfactory_epithelium0.94051079
74MP0006036_abnormal_mitochondrial_physio0.93421155
75MP0004233_abnormal_muscle_weight0.92866542
76MP0003941_abnormal_skin_development0.92808925
77MP0002111_abnormal_tail_morphology0.91777170
78MP0000358_abnormal_cell_content/0.89965777
79MP0000685_abnormal_immune_system0.89233832
80MP0006054_spinal_hemorrhage0.86815705
81MP0004264_abnormal_extraembryonic_tissu0.84635087
82MP0003315_abnormal_perineum_morphology0.84535614
83MP0003136_yellow_coat_color0.84403814
84MP0009672_abnormal_birth_weight0.83518928
85MP0009053_abnormal_anal_canal0.81717769
86MP0005174_abnormal_tail_pigmentation0.80563383
87MP0002163_abnormal_gland_morphology0.78323200
88MP0005389_reproductive_system_phenotype0.77991928
89MP0000653_abnormal_sex_gland0.77318122
90MP0004215_abnormal_myocardial_fiber0.77241930
91MP0005084_abnormal_gallbladder_morpholo0.75553779
92MP0002429_abnormal_blood_cell0.75469935
93MP0003221_abnormal_cardiomyocyte_apopto0.75093194
94MP0003121_genomic_imprinting0.74681594
95MP0001188_hyperpigmentation0.74563889
96MP0001929_abnormal_gametogenesis0.73080610
97MP0002282_abnormal_trachea_morphology0.70877683
98MP0002166_altered_tumor_susceptibility0.70789326
99MP0005220_abnormal_exocrine_pancreas0.70417340
100MP0006292_abnormal_olfactory_placode0.69779980
101MP0002405_respiratory_system_inflammati0.69072739
102MP0005266_abnormal_metabolism0.68640965
103MP0002095_abnormal_skin_pigmentation0.68139094
104MP0001853_heart_inflammation0.68104698
105MP0002653_abnormal_ependyma_morphology0.67812478
106MP0001919_abnormal_reproductive_system0.67029337
107MP0001119_abnormal_female_reproductive0.66894172
108MP0002090_abnormal_vision0.66731032
109MP0001186_pigmentation_phenotype0.66209763
110MP0001881_abnormal_mammary_gland0.64893490
111MP0002233_abnormal_nose_morphology0.63936043
112MP0000647_abnormal_sebaceous_gland0.63526350
113MP0000716_abnormal_immune_system0.63482830
114MP0002075_abnormal_coat/hair_pigmentati0.62509902
115MP0002006_tumorigenesis0.62490704
116MP0000470_abnormal_stomach_morphology0.61983844
117MP0000015_abnormal_ear_pigmentation0.61547686
118MP0009703_decreased_birth_body0.61097321
119MP0002160_abnormal_reproductive_system0.60899230
120MP0002751_abnormal_autonomic_nervous0.60295607
121MP0000477_abnormal_intestine_morphology0.60029698
122MP0001286_abnormal_eye_development0.59744798
123MP0005384_cellular_phenotype0.59356070
124MP0001661_extended_life_span0.59301931
125MP0000516_abnormal_urinary_system0.58894086
126MP0005253_abnormal_eye_physiology0.58374796
127MP0005395_other_phenotype0.58182245
128MP0005379_endocrine/exocrine_gland_phen0.54444698
129MP0000049_abnormal_middle_ear0.53835017
130MP0000613_abnormal_salivary_gland0.52997112
131MP0005367_renal/urinary_system_phenotyp0.51474717
132MP0005501_abnormal_skin_physiology0.51001716

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.04170583
2Reticulocytopenia (HP:0001896)4.64708226
3Increased hepatocellular lipid droplets (HP:0006565)4.62599640
4Abnormal number of erythroid precursors (HP:0012131)4.62477856
5Birth length less than 3rd percentile (HP:0003561)4.61167163
6Lipid accumulation in hepatocytes (HP:0006561)4.13576868
7Breast hypoplasia (HP:0003187)3.72935165
8Cerebral edema (HP:0002181)3.46951680
9Absent thumb (HP:0009777)3.33561055
10Patellar aplasia (HP:0006443)3.29896112
11Selective tooth agenesis (HP:0001592)3.26719680
12Increased serum pyruvate (HP:0003542)3.26598773
13Renal Fanconi syndrome (HP:0001994)3.23597458
14Abnormality of methionine metabolism (HP:0010901)3.17949410
15Cerebral hypomyelination (HP:0006808)3.15991560
16Macrocytic anemia (HP:0001972)3.14748715
17Aplastic anemia (HP:0001915)3.09295462
18Aplasia/Hypoplasia of the patella (HP:0006498)3.06567462
19Pallor (HP:0000980)3.06405527
20Hepatocellular necrosis (HP:0001404)3.05791336
21Premature graying of hair (HP:0002216)3.03996597
22Progressive macrocephaly (HP:0004481)3.02629300
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.00919290
24Degeneration of anterior horn cells (HP:0002398)2.98746459
25Abnormality of the anterior horn cell (HP:0006802)2.98746459
26Microvesicular hepatic steatosis (HP:0001414)2.96815664
27Absent radius (HP:0003974)2.94726694
28Oral leukoplakia (HP:0002745)2.93891795
29Rough bone trabeculation (HP:0100670)2.83765128
30Colon cancer (HP:0003003)2.81817780
31Tongue fasciculations (HP:0001308)2.79805429
32Abnormal hemoglobin (HP:0011902)2.79452959
33Poikiloderma (HP:0001029)2.79233695
34Hepatic necrosis (HP:0002605)2.77948242
35Increased intramyocellular lipid droplets (HP:0012240)2.74929835
36Methylmalonic acidemia (HP:0002912)2.72671740
37Lactic acidosis (HP:0003128)2.71848676
38Carpal bone hypoplasia (HP:0001498)2.70116881
39Aplasia involving forearm bones (HP:0009822)2.68115621
40Absent forearm bone (HP:0003953)2.68115621
41Duodenal stenosis (HP:0100867)2.66222791
42Small intestinal stenosis (HP:0012848)2.66222791
43Abnormality of serum amino acid levels (HP:0003112)2.61823889
44Rectal fistula (HP:0100590)2.61203474
45Rectovaginal fistula (HP:0000143)2.61203474
46Respiratory difficulties (HP:0002880)2.60792151
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59747738
48Muscle fiber atrophy (HP:0100295)2.58129368
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57380882
50Facial hemangioma (HP:0000329)2.55392200
51Abnormality of alanine metabolism (HP:0010916)2.55392165
52Hyperalaninemia (HP:0003348)2.55392165
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55392165
54Abnormality of the ileum (HP:0001549)2.51892850
55Squamous cell carcinoma (HP:0002860)2.50600139
56Type 2 muscle fiber atrophy (HP:0003554)2.47872196
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46513189
58Abnormality of the renal collecting system (HP:0004742)2.45194734
59Microretrognathia (HP:0000308)2.42450575
60Muscle fibrillation (HP:0010546)2.40719291
61Trismus (HP:0000211)2.39737276
62Multiple enchondromatosis (HP:0005701)2.38585224
63Type I transferrin isoform profile (HP:0003642)2.35746251
64Abnormal protein glycosylation (HP:0012346)2.35667306
65Abnormal glycosylation (HP:0012345)2.35667306
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35667306
67Abnormal protein N-linked glycosylation (HP:0012347)2.35667306
68Acute necrotizing encephalopathy (HP:0006965)2.35275745
69Rib fusion (HP:0000902)2.35260411
70Reduced antithrombin III activity (HP:0001976)2.32766490
71Basal cell carcinoma (HP:0002671)2.31681280
72Hypoplasia of the radius (HP:0002984)2.29966705
73Premature ovarian failure (HP:0008209)2.27965118
74Abnormality of the duodenum (HP:0002246)2.26552987
75Exertional dyspnea (HP:0002875)2.26297840
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25948339
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25948339
7811 pairs of ribs (HP:0000878)2.25378659
79Myelodysplasia (HP:0002863)2.24536057
80Embryonal renal neoplasm (HP:0011794)2.21606658
81Abnormal number of incisors (HP:0011064)2.20960941
82Vaginal fistula (HP:0004320)2.20694259
83Megaloblastic anemia (HP:0001889)2.17341431
84Abnormality of the preputium (HP:0100587)2.16783475
85Exercise intolerance (HP:0003546)2.16597688
86Lethargy (HP:0001254)2.15681130
87Respiratory failure (HP:0002878)2.14536241
88Increased IgM level (HP:0003496)2.14030397
89Aplasia/hypoplasia of the humerus (HP:0006507)2.13222851
90Meckel diverticulum (HP:0002245)2.12896440
91Increased muscle lipid content (HP:0009058)2.12630132
92Abnormal mitochondria in muscle tissue (HP:0008316)2.12099423
93Hyperglycinemia (HP:0002154)2.11118995
94Concave nail (HP:0001598)2.11001299
95Chromsome breakage (HP:0040012)2.10927169
96Intestinal atresia (HP:0011100)2.09714915
97Increased serum lactate (HP:0002151)2.09683853
98Medulloblastoma (HP:0002885)2.09660804
99Sloping forehead (HP:0000340)2.09510758
100Methylmalonic aciduria (HP:0012120)2.09357112
101Duplicated collecting system (HP:0000081)2.06680561
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06591972
103Triphalangeal thumb (HP:0001199)2.06162228
104Orthostatic hypotension (HP:0001278)2.05879009
105Intestinal fistula (HP:0100819)2.04554449
106Secondary amenorrhea (HP:0000869)2.03710815
107Abnormal trabecular bone morphology (HP:0100671)2.02323679
108Increased CSF lactate (HP:0002490)2.02253030
109Homocystinuria (HP:0002156)2.02243379
110Abnormality of homocysteine metabolism (HP:0010919)2.02243379
111Atresia of the external auditory canal (HP:0000413)2.01567338
112Pustule (HP:0200039)2.01261890
113Cleft eyelid (HP:0000625)2.00977615
114Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00589778
115Abnormality of the labia minora (HP:0012880)2.00378295
116IgG deficiency (HP:0004315)2.00218528
117Abnormality of chromosome stability (HP:0003220)2.00178377
118Cellular immunodeficiency (HP:0005374)1.99799785
119Lymphoma (HP:0002665)1.98739410
120Abnormal lung lobation (HP:0002101)1.98685845
121Stenosis of the external auditory canal (HP:0000402)1.97009312
122Thrombocytosis (HP:0001894)1.96515768
123Leukodystrophy (HP:0002415)1.96103905
124Neoplasm of the colon (HP:0100273)1.95947200
125Mitochondrial inheritance (HP:0001427)1.95274166
126IgM deficiency (HP:0002850)1.94543114
1273-Methylglutaconic aciduria (HP:0003535)1.94334308
128Neoplasm of the pancreas (HP:0002894)1.93550453
129Clubbing of toes (HP:0100760)1.93373014
130Supernumerary spleens (HP:0009799)1.91631717
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.90707067
132Vertebral hypoplasia (HP:0008417)1.90707067
133CNS hypomyelination (HP:0003429)1.89643377
134Bone marrow hypocellularity (HP:0005528)1.89132668
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.88756526
136Optic disc pallor (HP:0000543)1.85812640
137Neoplasm of the adrenal gland (HP:0100631)1.84318166
138Abnormality of renal resorption (HP:0011038)1.83191078
139Nephroblastoma (Wilms tumor) (HP:0002667)1.82874447
140Abnormality of the pons (HP:0007361)1.82650644
141Pancytopenia (HP:0001876)1.80043977
142Asplenia (HP:0001746)1.80005020
143Broad alveolar ridges (HP:0000187)1.79980802
144Sparse eyelashes (HP:0000653)1.79823131
145Ependymoma (HP:0002888)1.78741948
146Pancreatic islet-cell hyperplasia (HP:0004510)1.78266478
147Acute encephalopathy (HP:0006846)1.77761108
148Horseshoe kidney (HP:0000085)1.77437704
149Short thumb (HP:0009778)1.77391123
150Volvulus (HP:0002580)1.77107151
151Glossoptosis (HP:0000162)1.76525897
152Rhabdomyosarcoma (HP:0002859)1.76443181
153Abnormality of the umbilical cord (HP:0010881)1.76120453
154Abnormality of glycolysis (HP:0004366)1.75877025
155Abnormality of placental membranes (HP:0011409)1.73567221
156Amniotic constriction ring (HP:0009775)1.73567221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.32581696
2WEE13.97900651
3NME23.48492073
4EIF2AK13.17298496
5VRK23.01968484
6CDC72.67554802
7STK162.67345617
8EIF2AK32.45658540
9ACVR1B2.41468910
10SRPK12.35559304
11PIM22.20298382
12BRSK22.17693680
13DYRK31.98622565
14NUAK11.95041048
15CDK71.90284461
16MAP3K111.84924657
17NEK11.83964531
18VRK11.82011548
19RPS6KB21.81262417
20PLK11.78664200
21PASK1.77935248
22TSSK61.66738789
23TESK21.66597802
24NEK21.65794180
25MAP3K61.65325157
26TAF11.57182871
27TRIM281.47794881
28AURKB1.47438011
29ATR1.42190170
30MAPK151.38838981
31MKNK11.36688949
32PLK41.33496210
33BMPR1B1.31060291
34TTK1.26667723
35CHEK21.26237077
36DDR21.24812732
37ZAK1.24167433
38YES11.23468804
39TLK11.21889413
40PIM11.21332818
41RPS6KA41.19412730
42PDK21.19281612
43ICK1.18569196
44TGFBR11.18428742
45AURKA1.16311243
46PLK31.15784019
47MATK1.12078212
48MST41.12001397
49FLT31.08833041
50EPHA21.07808932
51DAPK10.93350638
52CDK80.92899385
53BRSK10.91928624
54CSNK2A10.88353976
55CDK60.87919053
56CHEK10.87674301
57MAP3K80.86681150
58BCKDK0.86295274
59CCNB10.84806143
60WNK30.84594775
61CSNK2A20.83236194
62TNIK0.82790580
63MAP4K20.78920044
64CDK190.78568881
65MAP3K120.78492737
66SCYL20.77774594
67CDK40.76417696
68MKNK20.75545100
69TAOK20.73887770
70NME10.73213445
71PAK40.72605347
72STK30.72119204
73KDR0.71767408
74STK100.70827135
75PINK10.70292550
76UHMK10.69631627
77ALK0.69468637
78MAP4K10.68212592
79STK40.67732727
80DYRK1B0.67431882
81PBK0.66103844
82DYRK20.64984349
83ATM0.64621872
84CDK20.64413660
85BCR0.62851512
86TESK10.62711602
87LRRK20.61987419
88MAPKAPK30.60791754
89CLK10.59789369
90PRKCI0.59587575
91MAP2K30.56224739
92ERBB30.54907542
93RPS6KL10.54000983
94RPS6KC10.54000983
95PAK10.53133977
96TEC0.51955921
97AKT30.50861962
98ERBB40.50808784
99RPS6KA60.50703887
100RPS6KA50.50651574
101ZAP700.50007202
102EIF2AK20.48323410
103CDK10.44751844
104CSK0.43939197
105ILK0.43321491
106FGR0.43238554
107STK390.42643652
108MELK0.41949615
109PLK20.41750268
110MAPKAPK50.41740213
111CSNK1G10.41627139
112CSNK1A1L0.41311131
113LYN0.40503902
114MAP3K30.40071591
115OXSR10.38533249
116CSNK1G30.38133930
117BRAF0.37847222
118IKBKB0.37104703
119BMPR20.37023028
120TRPM70.36809075
121LIMK10.36265783
122FGFR10.35402158
123BRD40.34310068
124STK240.33350177
125STK38L0.33227244
126CSNK1E0.30801420
127PRKDC0.30527991
128CSNK1G20.28476361
129GRK10.25703699
130CDK90.23143814
131CDK30.22914016
132RAF10.22823297
133LATS10.19654514

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58178443
2Ribosome_Homo sapiens_hsa030104.41910543
3Mismatch repair_Homo sapiens_hsa034304.36947165
4Proteasome_Homo sapiens_hsa030504.04011403
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54365088
6RNA polymerase_Homo sapiens_hsa030203.26464493
7Base excision repair_Homo sapiens_hsa034103.24640676
8Spliceosome_Homo sapiens_hsa030403.24221429
9Nucleotide excision repair_Homo sapiens_hsa034202.99334176
10RNA transport_Homo sapiens_hsa030132.92961961
11Homologous recombination_Homo sapiens_hsa034402.68241519
12Pyrimidine metabolism_Homo sapiens_hsa002402.33290491
13Cell cycle_Homo sapiens_hsa041102.19296726
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18690760
15Propanoate metabolism_Homo sapiens_hsa006402.04037626
16One carbon pool by folate_Homo sapiens_hsa006701.91375852
17Fanconi anemia pathway_Homo sapiens_hsa034601.87687803
18Basal transcription factors_Homo sapiens_hsa030221.84278697
19Protein export_Homo sapiens_hsa030601.79066697
20Non-homologous end-joining_Homo sapiens_hsa034501.78950544
21RNA degradation_Homo sapiens_hsa030181.71533329
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59436905
23mRNA surveillance pathway_Homo sapiens_hsa030151.59430527
24p53 signaling pathway_Homo sapiens_hsa041151.53448844
25Pyruvate metabolism_Homo sapiens_hsa006201.37105999
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30373405
27Parkinsons disease_Homo sapiens_hsa050121.20108443
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19779161
29Purine metabolism_Homo sapiens_hsa002301.17590372
30Folate biosynthesis_Homo sapiens_hsa007901.17090408
31Epstein-Barr virus infection_Homo sapiens_hsa051691.15992504
32Oxidative phosphorylation_Homo sapiens_hsa001901.11931725
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11669784
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09545672
35Huntingtons disease_Homo sapiens_hsa050161.04467182
36Primary immunodeficiency_Homo sapiens_hsa053400.93389931
37Systemic lupus erythematosus_Homo sapiens_hsa053220.92357789
38Antigen processing and presentation_Homo sapiens_hsa046120.81978315
39Herpes simplex infection_Homo sapiens_hsa051680.80934829
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80045994
41Biosynthesis of amino acids_Homo sapiens_hsa012300.79496596
42Sulfur relay system_Homo sapiens_hsa041220.78125047
43Steroid biosynthesis_Homo sapiens_hsa001000.77445671
44Viral carcinogenesis_Homo sapiens_hsa052030.75934545
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71483876
46Glutathione metabolism_Homo sapiens_hsa004800.71244347
47Legionellosis_Homo sapiens_hsa051340.71028374
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70234542
49Oocyte meiosis_Homo sapiens_hsa041140.66626942
50Sulfur metabolism_Homo sapiens_hsa009200.65550139
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.64029322
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60434816
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58385912
54N-Glycan biosynthesis_Homo sapiens_hsa005100.57820340
55Selenocompound metabolism_Homo sapiens_hsa004500.57645484
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56715859
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.55792427
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53272417
59Shigellosis_Homo sapiens_hsa051310.53174229
60Pentose phosphate pathway_Homo sapiens_hsa000300.52938420
61Arginine and proline metabolism_Homo sapiens_hsa003300.51510731
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51236454
63TGF-beta signaling pathway_Homo sapiens_hsa043500.50818516
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50360217
65Alzheimers disease_Homo sapiens_hsa050100.49736452
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.49204981
67Thyroid cancer_Homo sapiens_hsa052160.47545427
68HTLV-I infection_Homo sapiens_hsa051660.47181538
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45231785
70Hippo signaling pathway_Homo sapiens_hsa043900.44120186
71Peroxisome_Homo sapiens_hsa041460.42506389
72Fructose and mannose metabolism_Homo sapiens_hsa000510.42058233
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41339468
74Notch signaling pathway_Homo sapiens_hsa043300.38805874
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38135366
76Small cell lung cancer_Homo sapiens_hsa052220.37526479
77Metabolic pathways_Homo sapiens_hsa011000.35719356
78Measles_Homo sapiens_hsa051620.35108792
79Cardiac muscle contraction_Homo sapiens_hsa042600.34853731
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34139918
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33437777
82Hedgehog signaling pathway_Homo sapiens_hsa043400.33408353
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29816516
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28801805
85Carbon metabolism_Homo sapiens_hsa012000.28778154
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28579664
87Circadian rhythm_Homo sapiens_hsa047100.27930677
88Regulation of autophagy_Homo sapiens_hsa041400.27250950
89Butanoate metabolism_Homo sapiens_hsa006500.27192427
90Fatty acid metabolism_Homo sapiens_hsa012120.26545823
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.26533134
92Apoptosis_Homo sapiens_hsa042100.26413068
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26410260
94Colorectal cancer_Homo sapiens_hsa052100.25641142
95MicroRNAs in cancer_Homo sapiens_hsa052060.25224398
96Vitamin B6 metabolism_Homo sapiens_hsa007500.25001447
97Galactose metabolism_Homo sapiens_hsa000520.24741708
98Basal cell carcinoma_Homo sapiens_hsa052170.24372219
99Arachidonic acid metabolism_Homo sapiens_hsa005900.24168581
100Alcoholism_Homo sapiens_hsa050340.23797001
101Bladder cancer_Homo sapiens_hsa052190.23707603
102Fatty acid biosynthesis_Homo sapiens_hsa000610.22744023
103Allograft rejection_Homo sapiens_hsa053300.22225172
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.20918106
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20731452
106Viral myocarditis_Homo sapiens_hsa054160.19547279
107Adherens junction_Homo sapiens_hsa045200.18933104
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17494789
109Caffeine metabolism_Homo sapiens_hsa002320.17098503
110mTOR signaling pathway_Homo sapiens_hsa041500.16821134
111Hepatitis B_Homo sapiens_hsa051610.16336317
112Fatty acid degradation_Homo sapiens_hsa000710.16235413
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16191672
114Asthma_Homo sapiens_hsa053100.15961082
115Hematopoietic cell lineage_Homo sapiens_hsa046400.14812613
116Fatty acid elongation_Homo sapiens_hsa000620.14641463
117Starch and sucrose metabolism_Homo sapiens_hsa005000.13479321
118Vitamin digestion and absorption_Homo sapiens_hsa049770.13337417
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13296708
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.12953955
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11089641
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09584280
123Retinol metabolism_Homo sapiens_hsa008300.08918031
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06421755
125beta-Alanine metabolism_Homo sapiens_hsa004100.05881963
126Tryptophan metabolism_Homo sapiens_hsa003800.05223394
127Tyrosine metabolism_Homo sapiens_hsa003500.02280534
128Chemical carcinogenesis_Homo sapiens_hsa052040.01660443
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.00832296
130Phototransduction_Homo sapiens_hsa047440.00819295

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