EIF4A1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of memory T cell differentiation (GO:0043380)7.02209368
2DNA deamination (GO:0045006)5.55459164
3response to pheromone (GO:0019236)5.48153272
4regulation of regulatory T cell differentiation (GO:0045589)4.98491682
5ubiquinone biosynthetic process (GO:0006744)4.77495081
6positive regulation of defense response to virus by host (GO:0002230)4.71108294
7ubiquinone metabolic process (GO:0006743)4.23178495
8cytidine deamination (GO:0009972)4.13681120
9cytidine metabolic process (GO:0046087)4.13681120
10cytidine catabolic process (GO:0006216)4.13681120
11positive regulation of calcium-mediated signaling (GO:0050850)4.13467785
12water-soluble vitamin biosynthetic process (GO:0042364)4.05106416
13quinone biosynthetic process (GO:1901663)4.02168219
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90272745
15cellular response to interleukin-15 (GO:0071350)3.59554798
16protein complex biogenesis (GO:0070271)3.50312173
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47731108
18DNA integration (GO:0015074)3.43046606
19interferon-gamma secretion (GO:0072643)3.42705652
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.41933173
21NADH dehydrogenase complex assembly (GO:0010257)3.41933173
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41933173
23sulfation (GO:0051923)3.34117618
24regulation of immunoglobulin secretion (GO:0051023)3.33899743
25regulation of T cell receptor signaling pathway (GO:0050856)3.32116066
26positive regulation of T-helper cell differentiation (GO:0045624)3.31723191
27behavioral response to nicotine (GO:0035095)3.31698419
28positive regulation of interleukin-8 secretion (GO:2000484)3.29668433
29positive regulation of T cell cytokine production (GO:0002726)3.28188624
30pyrimidine ribonucleoside catabolic process (GO:0046133)3.27304983
31positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.24795836
32positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23987620
33cellular response to ATP (GO:0071318)3.21426306
34positive regulation of T cell mediated cytotoxicity (GO:0001916)3.20904768
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20494163
36DNA replication-dependent nucleosome assembly (GO:0006335)3.19987743
37DNA replication-dependent nucleosome organization (GO:0034723)3.19987743
38amino acid salvage (GO:0043102)3.17825318
39L-methionine salvage (GO:0071267)3.17825318
40L-methionine biosynthetic process (GO:0071265)3.17825318
41primary amino compound metabolic process (GO:1901160)3.16573329
42positive regulation of prostaglandin secretion (GO:0032308)3.14580565
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.11509347
44iron-sulfur cluster assembly (GO:0016226)3.08833688
45metallo-sulfur cluster assembly (GO:0031163)3.08833688
46GPI anchor metabolic process (GO:0006505)3.08285646
47histamine secretion (GO:0001821)3.08189260
48regulation of T cell mediated cytotoxicity (GO:0001914)3.07349204
49regulation of activation of Janus kinase activity (GO:0010533)3.06658398
50regulation of defense response to virus by host (GO:0050691)3.06271586
51artery smooth muscle contraction (GO:0014824)3.05604377
52protein localization to cilium (GO:0061512)3.05410995
53DNA double-strand break processing (GO:0000729)3.01988733
54positive regulation of natural killer cell mediated immunity (GO:0002717)3.01870749
55positive regulation of fatty acid transport (GO:2000193)3.00644819
56negative regulation of T-helper cell differentiation (GO:0045623)2.99843156
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99843156
58piRNA metabolic process (GO:0034587)2.99110579
59regulation of T-helper 1 type immune response (GO:0002825)2.98673986
60mitochondrial respiratory chain complex assembly (GO:0033108)2.98590759
61positive regulation of gamma-delta T cell activation (GO:0046645)2.98186947
62positive regulation of cell killing (GO:0031343)2.96161469
63positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.95808256
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95446845
65tolerance induction (GO:0002507)2.94660061
66protein polyglutamylation (GO:0018095)2.94176798
67Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93518206
68negative regulation by host of viral transcription (GO:0043922)2.93216183
69positive regulation of T-helper 1 type immune response (GO:0002827)2.91000464
70regulation of interleukin-8 secretion (GO:2000482)2.88905911
71positive regulation of activated T cell proliferation (GO:0042104)2.87100927
72termination of RNA polymerase III transcription (GO:0006386)2.86339286
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.86339286
74regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86175814
75GPI anchor biosynthetic process (GO:0006506)2.84617672
76positive regulation of B cell differentiation (GO:0045579)2.84128279
77regulation of cellular amino acid metabolic process (GO:0006521)2.80611726
78erythrocyte development (GO:0048821)2.80248508
79L-serine transport (GO:0015825)2.80002448
80respiratory chain complex IV assembly (GO:0008535)2.78791673
81regulation of cilium movement (GO:0003352)2.78395560
82auditory receptor cell stereocilium organization (GO:0060088)2.76485981
83regulation of T-helper 1 cell differentiation (GO:0045625)2.76076731
84positive regulation of cell fate commitment (GO:0010455)2.74563385
85eosinophil chemotaxis (GO:0048245)2.72641861
86regulation of cell killing (GO:0031341)2.72192750
87positive regulation of icosanoid secretion (GO:0032305)2.70421995
88positive regulation of T cell mediated immunity (GO:0002711)2.70225110
89negative regulation of thymocyte apoptotic process (GO:0070244)2.69120730
90vascular smooth muscle contraction (GO:0014829)2.69097455
91positive thymic T cell selection (GO:0045059)2.68263307
92response to interleukin-15 (GO:0070672)2.68226831
93regulation of icosanoid secretion (GO:0032303)2.67641700
94positive regulation of alpha-beta T cell differentiation (GO:0046638)2.65147152
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.64518360
96regulation of prostaglandin secretion (GO:0032306)2.64194978
97actin nucleation (GO:0045010)2.64171429
98regulation of alpha-beta T cell proliferation (GO:0046640)2.63973071
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.62671274
100regulation of calcium-mediated signaling (GO:0050848)2.61084274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.80158281
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.42544603
3VDR_22108803_ChIP-Seq_LS180_Human3.85827751
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.46092252
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45926703
6ZNF274_21170338_ChIP-Seq_K562_Hela3.27304076
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24858873
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19353883
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75585850
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74523563
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57870144
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41134261
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.37740819
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37329694
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.22329092
16GBX2_23144817_ChIP-Seq_PC3_Human2.16773001
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08348250
18EZH2_22144423_ChIP-Seq_EOC_Human2.06223735
19MYC_18940864_ChIP-ChIP_HL60_Human1.98666670
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98490877
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.94138278
22PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.86725089
23VDR_23849224_ChIP-Seq_CD4+_Human1.86717463
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81974597
25MYB_26560356_Chip-Seq_TH2_Human1.74560418
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60972350
27IRF1_19129219_ChIP-ChIP_H3396_Human1.59323781
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58363688
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.57884733
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57006496
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.54982524
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54982524
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52473066
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52190602
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.51378348
36EWS_26573619_Chip-Seq_HEK293_Human1.50851452
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.47406980
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46762946
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46291299
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43344470
41ERG_20517297_ChIP-Seq_VCAP_Human1.42843506
42GATA3_26560356_Chip-Seq_TH2_Human1.41085507
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37172144
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.34896493
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.32874053
46AR_20517297_ChIP-Seq_VCAP_Human1.32871430
47RUNX_20019798_ChIP-Seq_JUKART_Human1.32811056
48TP53_22573176_ChIP-Seq_HFKS_Human1.29537740
49FOXP3_21729870_ChIP-Seq_TREG_Human1.29059433
50IGF1R_20145208_ChIP-Seq_DFB_Human1.24563735
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24467168
52NANOG_20526341_ChIP-Seq_ESCs_Human1.20788674
53CIITA_25753668_ChIP-Seq_RAJI_Human1.13545434
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11661034
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11362709
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10496953
57TAF2_19829295_ChIP-Seq_ESCs_Human1.08241301
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04923259
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04352969
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04117902
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03700909
62FOXH1_21741376_ChIP-Seq_ESCs_Human1.02828082
63MYC_19829295_ChIP-Seq_ESCs_Human1.02334179
64GATA3_21878914_ChIP-Seq_MCF-7_Human0.98605586
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98491118
66P53_21459846_ChIP-Seq_SAOS-2_Human0.98272550
67CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97877416
68P300_19829295_ChIP-Seq_ESCs_Human0.97609021
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95989961
70GATA3_26560356_Chip-Seq_TH1_Human0.95692048
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95245676
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95161746
73OCT4_20526341_ChIP-Seq_ESCs_Human0.94329682
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94043535
75ELK1_19687146_ChIP-ChIP_HELA_Human0.93469714
76GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93180132
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.92862901
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92244622
79NCOR_22424771_ChIP-Seq_293T_Human0.90921099
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89986178
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.89763433
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89063732
83RAC3_21632823_ChIP-Seq_H3396_Human0.88971317
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88800594
85GATA3_27048872_Chip-Seq_THYMUS_Human0.88328565
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87916161
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87258529
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.87157536
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87115127
90ER_23166858_ChIP-Seq_MCF-7_Human0.86459608
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86094166
92HOXB7_26014856_ChIP-Seq_BT474_Human0.85146137
93RUNX2_22187159_ChIP-Seq_PCA_Human0.84960745
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84912884
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.84587198
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83181505
97SOX2_19829295_ChIP-Seq_ESCs_Human0.82585972
98NANOG_19829295_ChIP-Seq_ESCs_Human0.82585972
99BCL6_27268052_Chip-Seq_Bcells_Human0.79181984
100AR_21572438_ChIP-Seq_LNCaP_Human0.78786590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.81499812
2MP0005646_abnormal_pituitary_gland4.38504295
3MP0003787_abnormal_imprinting3.77469441
4MP0005645_abnormal_hypothalamus_physiol3.19467595
5MP0008875_abnormal_xenobiotic_pharmacok2.52700947
6MP0005084_abnormal_gallbladder_morpholo2.30263328
7MP0002148_abnormal_hypersensitivity_rea2.25986108
8MP0003950_abnormal_plasma_membrane2.15155278
9MP0002166_altered_tumor_susceptibility2.11123749
10MP0004147_increased_porphyrin_level2.07073931
11MP0003724_increased_susceptibility_to2.03706848
12MP0005167_abnormal_blood-brain_barrier1.95689740
13MP0009785_altered_susceptibility_to1.85515475
14MP0002102_abnormal_ear_morphology1.83215903
15MP0005410_abnormal_fertilization1.76852224
16MP0010155_abnormal_intestine_physiology1.76803477
17MP0003763_abnormal_thymus_physiology1.76357791
18MP0001800_abnormal_humoral_immune1.73978423
19MP0002723_abnormal_immune_serum1.73773953
20MP0005000_abnormal_immune_tolerance1.73125375
21MP0009046_muscle_twitch1.69659862
22MP0001485_abnormal_pinna_reflex1.64248360
23MP0002006_tumorigenesis1.61027811
24MP0009333_abnormal_splenocyte_physiolog1.59346856
25MP0008872_abnormal_physiological_respon1.57728368
26MP0004742_abnormal_vestibular_system1.55759910
27MP0002452_abnormal_antigen_presenting1.51219944
28MP0009697_abnormal_copulation1.47590414
29MP0001764_abnormal_homeostasis1.47532210
30MP0001819_abnormal_immune_cell1.47278288
31MP0002420_abnormal_adaptive_immunity1.44534329
32MP0001835_abnormal_antigen_presentation1.43639243
33MP0001968_abnormal_touch/_nociception1.43457183
34MP0000372_irregular_coat_pigmentation1.41004288
35MP0002009_preneoplasia1.39263998
36MP0003123_paternal_imprinting1.34474787
37MP0002277_abnormal_respiratory_mucosa1.31622680
38MP0003567_abnormal_fetal_cardiomyocyte1.27496446
39MP0001765_abnormal_ion_homeostasis1.26729050
40MP0005025_abnormal_response_to1.26012276
41MP0008058_abnormal_DNA_repair1.23250909
42MP0002933_joint_inflammation1.23107800
43MP0000631_abnormal_neuroendocrine_gland1.23101160
44MP0001986_abnormal_taste_sensitivity1.18548874
45MP0005083_abnormal_biliary_tract1.16475451
46MP0005360_urolithiasis1.14665599
47MP0009745_abnormal_behavioral_response1.13923431
48MP0000490_abnormal_crypts_of1.12846639
49MP0006035_abnormal_mitochondrial_morpho1.12718731
50MP0002138_abnormal_hepatobiliary_system1.10813514
51MP0001790_abnormal_immune_system1.10251588
52MP0005387_immune_system_phenotype1.10251588
53MP0002751_abnormal_autonomic_nervous1.09977185
54MP0003121_genomic_imprinting1.09565035
55MP0001845_abnormal_inflammatory_respons1.09333182
56MP0002733_abnormal_thermal_nociception1.08442650
57MP0003119_abnormal_digestive_system1.08047568
58MP0008469_abnormal_protein_level1.07267004
59MP0010386_abnormal_urinary_bladder1.04308068
60MP0000716_abnormal_immune_system1.02462288
61MP0004947_skin_inflammation1.02067556
62MP0009764_decreased_sensitivity_to1.01374966
63MP0001984_abnormal_olfaction1.01176811
64MP0004145_abnormal_muscle_electrophysio1.00062741
65MP0006082_CNS_inflammation0.97274776
66MP0000678_abnormal_parathyroid_gland0.95678354
67MP0001529_abnormal_vocalization0.92922992
68MP0000465_gastrointestinal_hemorrhage0.92279345
69MP0001905_abnormal_dopamine_level0.92276676
70MP0001486_abnormal_startle_reflex0.91899167
71MP0009384_cardiac_valve_regurgitation0.90884848
72MP0000689_abnormal_spleen_morphology0.90443885
73MP0002234_abnormal_pharynx_morphology0.89567216
74MP0002139_abnormal_hepatobiliary_system0.89496155
75MP0003718_maternal_effect0.87776624
76MP0001919_abnormal_reproductive_system0.86982683
77MP0005253_abnormal_eye_physiology0.86967776
78MP0002132_abnormal_respiratory_system0.86480823
79MP0005377_hearing/vestibular/ear_phenot0.86217044
80MP0003878_abnormal_ear_physiology0.86217044
81MP0002419_abnormal_innate_immunity0.86054960
82MP0000685_abnormal_immune_system0.85465715
83MP0005636_abnormal_mineral_homeostasis0.83441543
84MP0002064_seizures0.83209855
85MP0002722_abnormal_immune_system0.82536373
86MP0000703_abnormal_thymus_morphology0.80929502
87MP0005389_reproductive_system_phenotype0.80851770
88MP0003638_abnormal_response/metabolism_0.80116278
89MP0002272_abnormal_nervous_system0.79890208
90MP0005551_abnormal_eye_electrophysiolog0.79451090
91MP0000230_abnormal_systemic_arterial0.78713946
92MP0000013_abnormal_adipose_tissue0.78704769
93MP0005319_abnormal_enzyme/_coenzyme0.78594438
94MP0002429_abnormal_blood_cell0.78269395
95MP0009643_abnormal_urine_homeostasis0.77361573
96MP0003252_abnormal_bile_duct0.76681267
97MP0000750_abnormal_muscle_regeneration0.76447060
98MP0010329_abnormal_lipoprotein_level0.75808133
99MP0004142_abnormal_muscle_tone0.75029341
100MP0005075_abnormal_melanosome_morpholog0.74615833

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)4.39989325
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.26576152
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.26576152
4IgG deficiency (HP:0004315)4.19699284
5Progressive inability to walk (HP:0002505)4.18390969
6Abnormality of the prostate (HP:0008775)3.81094128
7Hypoplasia of the uterus (HP:0000013)3.54854041
8Inability to walk (HP:0002540)3.44899944
9Thyroiditis (HP:0100646)3.42507882
10Decreased electroretinogram (ERG) amplitude (HP:0000654)3.41731580
11Cerebral hypomyelination (HP:0006808)3.41671394
12Unilateral renal agenesis (HP:0000122)3.37712728
13Combined immunodeficiency (HP:0005387)3.32523968
14Mesangial abnormality (HP:0001966)3.19276482
15Abnormality of eosinophils (HP:0001879)3.16634285
16Chronic otitis media (HP:0000389)3.15533883
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.03662174
18Absent/shortened dynein arms (HP:0200106)3.03662174
19Gaze-evoked nystagmus (HP:0000640)3.03266591
20Abolished electroretinogram (ERG) (HP:0000550)2.93698229
21Facial shape deformation (HP:0011334)2.93112583
22Potter facies (HP:0002009)2.93112583
23Congenital stationary night blindness (HP:0007642)2.92642418
24T lymphocytopenia (HP:0005403)2.92343784
25Stomach cancer (HP:0012126)2.90112505
26Abnormality of T cell number (HP:0011839)2.88667196
27Chronic diarrhea (HP:0002028)2.87743283
28Aplasia/hypoplasia of the uterus (HP:0008684)2.87627208
29Agammaglobulinemia (HP:0004432)2.78370488
30Elevated erythrocyte sedimentation rate (HP:0003565)2.65105354
31Stomatitis (HP:0010280)2.60784807
32Constricted visual fields (HP:0001133)2.57174390
33Hypoproteinemia (HP:0003075)2.49582617
34Medial flaring of the eyebrow (HP:0010747)2.48792603
35Type II lissencephaly (HP:0007260)2.41522025
36Abnormality of male internal genitalia (HP:0000022)2.41437718
37Abnormality of B cell number (HP:0010975)2.39643843
38Pancreatic cysts (HP:0001737)2.34589281
39Autoimmune hemolytic anemia (HP:0001890)2.32770850
40CNS hypomyelination (HP:0003429)2.30570671
41Large for gestational age (HP:0001520)2.26201320
42Eosinophilia (HP:0001880)2.25570205
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24538033
44Thick nail (HP:0001805)2.23519606
45Female pseudohermaphroditism (HP:0010458)2.23236618
46Increased hepatocellular lipid droplets (HP:0006565)2.21964849
47Abnormality of the renal collecting system (HP:0004742)2.20720048
48Attenuation of retinal blood vessels (HP:0007843)2.17536136
49Anhidrosis (HP:0000970)2.15589448
50Lipid accumulation in hepatocytes (HP:0006561)2.14852036
51Vacuolated lymphocytes (HP:0001922)2.11140328
52Arthropathy (HP:0003040)2.10686168
53Brushfield spots (HP:0001088)2.09413577
54Autoimmune thrombocytopenia (HP:0001973)2.09285406
55Nephrogenic diabetes insipidus (HP:0009806)2.08482503
56Duplicated collecting system (HP:0000081)2.07461635
57Cerebellar dysplasia (HP:0007033)2.07424520
58Granulocytopenia (HP:0001913)2.06683439
59Abnormality of the labia minora (HP:0012880)2.06556698
60Congenital primary aphakia (HP:0007707)2.04676143
61Rectovaginal fistula (HP:0000143)2.03627180
62Rectal fistula (HP:0100590)2.03627180
63Abnormality of T cells (HP:0002843)2.03527915
64IgM deficiency (HP:0002850)2.03465251
65Gait imbalance (HP:0002141)1.99679654
66Increased IgM level (HP:0003496)1.99439838
67B lymphocytopenia (HP:0010976)1.98270643
68True hermaphroditism (HP:0010459)1.98115299
69Chorioretinal atrophy (HP:0000533)1.96837570
70Bone cyst (HP:0012062)1.91412468
71Abnormality of the renal cortex (HP:0011035)1.87978852
72Tubular atrophy (HP:0000092)1.86911833
73Mitochondrial inheritance (HP:0001427)1.86566844
74Gonadal dysgenesis (HP:0000133)1.85805705
75J-shaped sella turcica (HP:0002680)1.85370843
76Neuroendocrine neoplasm (HP:0100634)1.85139971
77Abnormal drinking behavior (HP:0030082)1.82608571
78Polydipsia (HP:0001959)1.82608571
79Hypothermia (HP:0002045)1.81643484
80Cerebral palsy (HP:0100021)1.78947933
81Hypokalemic alkalosis (HP:0001949)1.78657834
82Abnormal respiratory motile cilium morphology (HP:0005938)1.76806262
83Abnormal respiratory epithelium morphology (HP:0012253)1.76806262
84Long nose (HP:0003189)1.75684743
85Recurrent corneal erosions (HP:0000495)1.74181508
86Hepatocellular necrosis (HP:0001404)1.73460383
87Tetany (HP:0001281)1.73032086
88Leukocytosis (HP:0001974)1.71795837
89Premature loss of primary teeth (HP:0006323)1.71256072
90Epiphyseal stippling (HP:0010655)1.71251262
91Bile duct proliferation (HP:0001408)1.70733914
92Abnormal biliary tract physiology (HP:0012439)1.70733914
93Alkalosis (HP:0001948)1.69952695
94Pancreatic fibrosis (HP:0100732)1.69803130
95Vaginal fistula (HP:0004320)1.69534621
96Facial diplegia (HP:0001349)1.69102971
97Nephrotic syndrome (HP:0000100)1.67721033
98Prostate neoplasm (HP:0100787)1.66663194
99Polyuria (HP:0000103)1.66487735
100Beaking of vertebral bodies (HP:0004568)1.64227391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.32669496
2ZAK6.84104084
3TNK23.21219142
4TIE13.18560084
5VRK12.77092438
6VRK22.59499654
7MAPKAPK32.44598074
8WNK32.43307490
9ADRBK22.09237131
10KDR2.00502504
11TEC1.87948780
12TAOK31.84670204
13TXK1.74233714
14MAPKAPK51.57102605
15TRIM281.52378684
16BCKDK1.51093415
17TNIK1.44829016
18TESK21.43908784
19CCNB11.39528921
20CSNK1G31.37392784
21ITK1.32639296
22NUAK11.29876682
23MAP3K131.28237366
24RPS6KA51.25341741
25BMPR1B1.23076633
26CSNK1A1L1.20850947
27MAP4K11.19273283
28TAF11.18840915
29CSNK1G11.17588181
30GRK11.17530633
31CSNK1G21.01164141
32MAP2K70.97963049
33FRK0.94243926
34PKN10.93236920
35GRK60.92743004
36MAP3K140.92501387
37SCYL20.90848547
38MAP2K20.90254174
39SYK0.86161953
40PRKCQ0.83436618
41MAP3K60.81261381
42ADRBK10.80961202
43WNK40.80035654
44GRK70.77355179
45OXSR10.75960157
46PBK0.75708905
47IKBKB0.74636000
48MAPK110.74492355
49TRPM70.74057527
50BUB10.72477720
51TSSK60.67482046
52BCR0.66623429
53FES0.63444223
54MAP3K40.63391640
55PIM10.63148109
56EPHA30.62922075
57STK390.62054235
58LIMK10.60616818
59EEF2K0.60373558
60MST40.58942034
61CSF1R0.56946043
62RPS6KA40.56761397
63DAPK10.55270637
64MAPK130.54229544
65IKBKE0.51464117
66MKNK10.51097544
67AURKA0.50355187
68STK240.48625092
69BTK0.48481903
70STK160.45057995
71MAP4K20.44483658
72ACVR1B0.44241741
73SIK30.43200709
74MAP2K10.41594720
75GRK50.41550123
76MAP2K60.40668082
77TBK10.39884293
78IRAK10.39771163
79KIT0.38243180
80LCK0.37441620
81CHUK0.35764637
82INSRR0.33480671
83INSR0.32574914
84ZAP700.32335433
85DAPK20.29631701
86FER0.29239576
87RPS6KB20.28216578
88LYN0.27436427
89SRPK10.27115381
90PRKCG0.26970852
91TESK10.26647479
92PRKAA10.26446360
93MYLK0.24709427
94PINK10.24599232
95PRKCA0.21929900
96PRKCD0.21162723
97CSNK1D0.21080855
98IGF1R0.20465708
99DAPK30.19473085
100MATK0.19136448

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.83384759
2Proteasome_Homo sapiens_hsa030503.33781869
3Systemic lupus erythematosus_Homo sapiens_hsa053222.90088064
4Nitrogen metabolism_Homo sapiens_hsa009102.76612284
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.64395225
6Sulfur metabolism_Homo sapiens_hsa009202.58712588
7Selenocompound metabolism_Homo sapiens_hsa004502.41909337
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30355944
9Asthma_Homo sapiens_hsa053102.28579528
10Graft-versus-host disease_Homo sapiens_hsa053322.20952659
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19737677
12RNA polymerase_Homo sapiens_hsa030202.17661782
13Autoimmune thyroid disease_Homo sapiens_hsa053202.00579397
14Allograft rejection_Homo sapiens_hsa053301.92040824
15Sulfur relay system_Homo sapiens_hsa041221.91192162
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88770588
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80011867
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.72913131
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69349209
20Antigen processing and presentation_Homo sapiens_hsa046121.66967376
21Linoleic acid metabolism_Homo sapiens_hsa005911.65595172
22Alcoholism_Homo sapiens_hsa050341.54359550
23Oxidative phosphorylation_Homo sapiens_hsa001901.51623553
24Rheumatoid arthritis_Homo sapiens_hsa053231.50286239
25Type I diabetes mellitus_Homo sapiens_hsa049401.44832544
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43354860
27Phototransduction_Homo sapiens_hsa047441.40493006
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.38201379
29Parkinsons disease_Homo sapiens_hsa050121.30349410
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20759615
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20458480
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17238580
33Peroxisome_Homo sapiens_hsa041461.16416176
34Nicotine addiction_Homo sapiens_hsa050331.06429229
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04624238
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01884469
37Homologous recombination_Homo sapiens_hsa034401.01547651
38Chemical carcinogenesis_Homo sapiens_hsa052040.97329074
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92488466
40Ether lipid metabolism_Homo sapiens_hsa005650.92247885
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91548377
42Viral myocarditis_Homo sapiens_hsa054160.90626479
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90203753
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89425202
45T cell receptor signaling pathway_Homo sapiens_hsa046600.89369673
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.88708857
47One carbon pool by folate_Homo sapiens_hsa006700.85868826
48Staphylococcus aureus infection_Homo sapiens_hsa051500.84224996
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.83592560
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.82839922
51Circadian entrainment_Homo sapiens_hsa047130.82751163
52Caffeine metabolism_Homo sapiens_hsa002320.81525233
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76879862
54Hematopoietic cell lineage_Homo sapiens_hsa046400.76860678
55Tryptophan metabolism_Homo sapiens_hsa003800.75896649
56Protein export_Homo sapiens_hsa030600.75768212
57Olfactory transduction_Homo sapiens_hsa047400.74283975
58Butanoate metabolism_Homo sapiens_hsa006500.73787855
59Purine metabolism_Homo sapiens_hsa002300.71015752
60Fat digestion and absorption_Homo sapiens_hsa049750.67618287
61Pyrimidine metabolism_Homo sapiens_hsa002400.67529367
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66274286
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.65544975
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.62507249
65Arachidonic acid metabolism_Homo sapiens_hsa005900.61163791
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60947649
67Alzheimers disease_Homo sapiens_hsa050100.60195548
68Serotonergic synapse_Homo sapiens_hsa047260.59948074
69Long-term depression_Homo sapiens_hsa047300.59609053
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59227299
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56806940
72Taste transduction_Homo sapiens_hsa047420.56147326
73Propanoate metabolism_Homo sapiens_hsa006400.55423085
74Morphine addiction_Homo sapiens_hsa050320.55397628
75Fanconi anemia pathway_Homo sapiens_hsa034600.53718850
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53258247
77Arginine biosynthesis_Homo sapiens_hsa002200.51685470
78Renin secretion_Homo sapiens_hsa049240.50600000
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49571623
80DNA replication_Homo sapiens_hsa030300.46500216
81Spliceosome_Homo sapiens_hsa030400.46167392
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43448458
83Retinol metabolism_Homo sapiens_hsa008300.41253326
84Phenylalanine metabolism_Homo sapiens_hsa003600.40670152
85Glycerolipid metabolism_Homo sapiens_hsa005610.38800860
86Glutamatergic synapse_Homo sapiens_hsa047240.37327423
87Cardiac muscle contraction_Homo sapiens_hsa042600.36210056
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35900528
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.34988582
90Non-homologous end-joining_Homo sapiens_hsa034500.34968886
91Viral carcinogenesis_Homo sapiens_hsa052030.34720327
92GABAergic synapse_Homo sapiens_hsa047270.34635361
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31833905
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31817877
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31610987
96Metabolic pathways_Homo sapiens_hsa011000.31025729
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30561968
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30118433
99Vitamin digestion and absorption_Homo sapiens_hsa049770.30110667
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29751722

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