ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.79591984
2	protein deneddylation (GO:0000338)	4.39063523
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.13460810
4	iron-sulfur cluster assembly (GO:0016226)	4.02329158
5	metallo-sulfur cluster assembly (GO:0031163)	4.02329158
6	sequestering of actin monomers (GO:0042989)	3.97151646
7	cullin deneddylation (GO:0010388)	3.94082052
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.83525987
9	cytidine metabolic process (GO:0046087)	3.81660232
10	cytidine catabolic process (GO:0006216)	3.81660232
11	cytidine deamination (GO:0009972)	3.81660232
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.79528787
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.79528787
14	positive regulation of mitochondrial fission (GO:0090141)	3.70143674
15	positive regulation of prostaglandin secretion (GO:0032308)	3.59897175
16	base-excision repair, AP site formation (GO:0006285)	3.49152622
17	amino acid salvage (GO:0043102)	3.46937169
18	L-methionine salvage (GO:0071267)	3.46937169
19	L-methionine biosynthetic process (GO:0071265)	3.46937169
20	mannosylation (GO:0097502)	3.41478918
21	regulation of cellular amino acid metabolic process (GO:0006521)	3.28310975
22	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.27390730
23	peptidyl-arginine omega-N-methylation (GO:0035247)	3.21825009
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20813630
25	ubiquinone biosynthetic process (GO:0006744)	3.20301060
26	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.19816020
27	branched-chain amino acid catabolic process (GO:0009083)	3.18887797
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.18205542
29	adenosine metabolic process (GO:0046085)	3.15755969
30	proteasome assembly (GO:0043248)	3.14899362
31	protein-cofactor linkage (GO:0018065)	3.14219865
32	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.14180908
33	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.14005042
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.12701185
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.12701185
36	NADH dehydrogenase complex assembly (GO:0010257)	3.12701185
37	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.11756858
38	ubiquinone metabolic process (GO:0006743)	3.09767637
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.09203172
40	sleep (GO:0030431)	3.09116317
41	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.06153236
42	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.06021602
43	chaperone-mediated protein transport (GO:0072321)	3.04575169
44	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.02743020
45	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.02743020
46	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.02743020
47	GPI anchor biosynthetic process (GO:0006506)	3.00918521
48	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.99255538
49	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.99255538
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.98388881
51	regulation of mitotic spindle checkpoint (GO:1903504)	2.98388881
52	protein polyglutamylation (GO:0018095)	2.97899065
53	protein complex biogenesis (GO:0070271)	2.94538599
54	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.91773350
55	GPI anchor metabolic process (GO:0006505)	2.91750736
56	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.91238591
57	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.88885856
58	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.88885856
59	termination of RNA polymerase III transcription (GO:0006386)	2.88329776
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88329776
61	protein neddylation (GO:0045116)	2.85116020
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84580209
63	response to gravity (GO:0009629)	2.82266330
64	mitochondrial RNA metabolic process (GO:0000959)	2.80525231
65	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.80467577
66	pseudouridine synthesis (GO:0001522)	2.79804351
67	peptidyl-arginine methylation (GO:0018216)	2.77996161
68	peptidyl-arginine N-methylation (GO:0035246)	2.77996161
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.77078352
70	GTP biosynthetic process (GO:0006183)	2.76216371
71	regulation of prostaglandin secretion (GO:0032306)	2.76000280
72	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.75670074
73	negative regulation of ligase activity (GO:0051352)	2.75670074
74	DNA double-strand break processing (GO:0000729)	2.75441655
75	positive regulation of defense response to virus by host (GO:0002230)	2.75422177
76	positive regulation of T cell cytokine production (GO:0002726)	2.74654287
77	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.72930111
78	GMP metabolic process (GO:0046037)	2.72018550
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68897935
80	tRNA processing (GO:0008033)	2.66776270
81	spliceosomal snRNP assembly (GO:0000387)	2.61828345
82	actin nucleation (GO:0045010)	2.60400971
83	negative regulation of meiotic cell cycle (GO:0051447)	2.60325323
84	tRNA modification (GO:0006400)	2.57676896
85	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.55278397
86	DNA catabolic process, exonucleolytic (GO:0000738)	2.54587390
87	regulation of mitochondrial fission (GO:0090140)	2.54547018
88	regulation of chronic inflammatory response (GO:0002676)	2.53378182
89	cellular response to interleukin-15 (GO:0071350)	2.52959179
90	methionine biosynthetic process (GO:0009086)	2.52817193
91	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.52374629
92	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.52216173
93	de novo posttranslational protein folding (GO:0051084)	2.50042431
94	guanosine-containing compound biosynthetic process (GO:1901070)	2.49126816
95	branched-chain amino acid metabolic process (GO:0009081)	2.49020851
96	regulation of defense response to virus by host (GO:0050691)	2.48755711
97	histone arginine methylation (GO:0034969)	2.48171433
98	DNA demethylation (GO:0080111)	2.47390145
99	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.46821136
100	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.44826387

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.70737424
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.45224099
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.18021098
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13371520
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.69375242
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29880400
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12341406
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.02321635
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00453478
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.96650503
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80259836
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.55289580
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.54610024
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.49601198
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31569848
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.28800178
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.20182679
18	VDR_22108803_ChIP-Seq_LS180_Human	2.14864589
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.14526418
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.05707330
21	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.03074657
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.97787579
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96811701
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.95572148
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.93678325
26	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.91126217
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.85681693
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.83112693
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.81304175
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80270404
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.80055929
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.77085785
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67035086
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.65145257
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.64810914
36	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63170769
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.62605580
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.62141866
39	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.58040055
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58033482
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.56375074
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.54167265
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.52296664
44	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.52233598
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.51168596
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50545259
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.45770945
48	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.45447793
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41556414
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40174333
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37690621
52	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.37028151
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36624898
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.35540541
55	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.32993825
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30376225
57	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26850200
58	MYB_26560356_Chip-Seq_TH2_Human	1.26284169
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.25284270
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.25207291
61	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25123848
62	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24542909
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24235074
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24096865
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.23806429
66	GATA3_26560356_Chip-Seq_TH2_Human	1.23775146
67	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.23537643
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19963141
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18148656
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16585440
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14947774
72	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.14838148
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14244645
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12680872
75	AR_20517297_ChIP-Seq_VCAP_Human	1.11076185
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10312729
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09010149
78	EWS_26573619_Chip-Seq_HEK293_Human	1.07410986
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.05785144
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05451361
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01911246
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98549551
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98549551
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95785700
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.94213454
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93156564
87	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93050892
88	CBP_20019798_ChIP-Seq_JUKART_Human	0.92088128
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92088128
90	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91993807
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.91874659
92	FUS_26573619_Chip-Seq_HEK293_Human	0.91241741
93	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.91218181
94	SPI1_23547873_ChIP-Seq_NB4_Human	0.90686795
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.88915121
96	GATA3_27048872_Chip-Seq_THYMUS_Human	0.88470688
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.87909874
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86273740
99	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.85788332
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.81591230

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.53802459
2	MP0005671_abnormal_response_to	3.45512190
3	MP0002102_abnormal_ear_morphology	3.32797096
4	MP0008789_abnormal_olfactory_epithelium	2.53939460
5	MP0003786_premature_aging	2.49699976
6	MP0008058_abnormal_DNA_repair	2.47685124
7	MP0008995_early_reproductive_senescence	2.47332604
8	MP0004147_increased_porphyrin_level	2.40841867
9	MP0005253_abnormal_eye_physiology	2.26413468
10	MP0003724_increased_susceptibility_to	2.16596653
11	MP0008877_abnormal_DNA_methylation	2.15179949
12	MP0002736_abnormal_nociception_after	2.11570303
13	MP0001529_abnormal_vocalization	2.03534269
14	MP0001835_abnormal_antigen_presentation	2.02308321
15	MP0001968_abnormal_touch/_nociception	2.00907614
16	MP0000372_irregular_coat_pigmentation	2.00262210
17	MP0005084_abnormal_gallbladder_morpholo	1.92987386
18	MP0005499_abnormal_olfactory_system	1.83818499
19	MP0005394_taste/olfaction_phenotype	1.83818499
20	MP0009785_altered_susceptibility_to	1.81998528
21	MP0006276_abnormal_autonomic_nervous	1.72220183
22	MP0002148_abnormal_hypersensitivity_rea	1.67496686
23	MP0003011_delayed_dark_adaptation	1.65495745
24	MP0005000_abnormal_immune_tolerance	1.60791495
25	MP0003806_abnormal_nucleotide_metabolis	1.59926828
26	MP0001905_abnormal_dopamine_level	1.59865512
27	MP0010094_abnormal_chromosome_stability	1.59556003
28	MP0005551_abnormal_eye_electrophysiolog	1.58761792
29	MP0009764_decreased_sensitivity_to	1.55833801
30	MP0000685_abnormal_immune_system	1.52368207
31	MP0002723_abnormal_immune_serum	1.50522150
32	MP0008875_abnormal_xenobiotic_pharmacok	1.49685384
33	MP0003436_decreased_susceptibility_to	1.47550881
34	MP0005645_abnormal_hypothalamus_physiol	1.45268155
35	MP0006035_abnormal_mitochondrial_morpho	1.44797920
36	MP0006036_abnormal_mitochondrial_physio	1.41551186
37	MP0003195_calcinosis	1.38851087
38	MP0005646_abnormal_pituitary_gland	1.36837165
39	MP0001984_abnormal_olfaction	1.35981507
40	MP0002822_catalepsy	1.35967156
41	MP0001800_abnormal_humoral_immune	1.34870265
42	MP0001819_abnormal_immune_cell	1.31759655
43	MP0001986_abnormal_taste_sensitivity	1.31408943
44	MP0002420_abnormal_adaptive_immunity	1.30064581
45	MP0000013_abnormal_adipose_tissue	1.29797659
46	MP0008872_abnormal_physiological_respon	1.28132517
47	MP0004145_abnormal_muscle_electrophysio	1.22810531
48	MP0003763_abnormal_thymus_physiology	1.22786709
49	MP0002452_abnormal_antigen_presenting	1.22464252
50	MP0000465_gastrointestinal_hemorrhage	1.22178646
51	MP0005075_abnormal_melanosome_morpholog	1.19432268
52	MP0002751_abnormal_autonomic_nervous	1.19337631
53	MP0001764_abnormal_homeostasis	1.15517996
54	MP0009697_abnormal_copulation	1.14501834
55	MP0003693_abnormal_embryo_hatching	1.12978586
56	MP0000689_abnormal_spleen_morphology	1.11033946
57	MP0004142_abnormal_muscle_tone	1.10507462
58	MP0003718_maternal_effect	1.07955862
59	MP0002722_abnormal_immune_system	1.04920892
60	MP0000716_abnormal_immune_system	1.04283369
61	MP0000647_abnormal_sebaceous_gland	1.03345200
62	MP0002876_abnormal_thyroid_physiology	1.02789084
63	MP0009333_abnormal_splenocyte_physiolog	0.99819710
64	MP0002398_abnormal_bone_marrow	0.98852346
65	MP0002234_abnormal_pharynx_morphology	0.98370935
66	MP0005025_abnormal_response_to	0.95994942
67	MP0001919_abnormal_reproductive_system	0.93316079
68	MP0002653_abnormal_ependyma_morphology	0.93212100
69	MP0002006_tumorigenesis	0.92860275
70	MP0000703_abnormal_thymus_morphology	0.92500539
71	MP0002166_altered_tumor_susceptibility	0.90517276
72	MP0006292_abnormal_olfactory_placode	0.90400889
73	MP0005389_reproductive_system_phenotype	0.89857476
74	MP0008007_abnormal_cellular_replicative	0.89847265
75	MP0002429_abnormal_blood_cell	0.86216263
76	MP0002019_abnormal_tumor_incidence	0.83563051
77	MP0005167_abnormal_blood-brain_barrier	0.83137724
78	MP0005410_abnormal_fertilization	0.81503289
79	MP0000049_abnormal_middle_ear	0.81267829
80	MP0001501_abnormal_sleep_pattern	0.80616122
81	MP0001845_abnormal_inflammatory_respons	0.79557978
82	MP0002405_respiratory_system_inflammati	0.78715270
83	MP0009763_increased_sensitivity_to	0.77810722
84	MP0003787_abnormal_imprinting	0.77632324
85	MP0009765_abnormal_xenobiotic_induced	0.76686140
86	MP0008775_abnormal_heart_ventricle	0.76277601
87	MP0002419_abnormal_innate_immunity	0.76151430
88	MP0003646_muscle_fatigue	0.75845121
89	MP0003866_abnormal_defecation	0.74610493
90	MP0001929_abnormal_gametogenesis	0.73403227
91	MP0009745_abnormal_behavioral_response	0.71415565
92	MP0002282_abnormal_trachea_morphology	0.69877179
93	MP0001119_abnormal_female_reproductive	0.69416181
94	MP0003221_abnormal_cardiomyocyte_apopto	0.69301214
95	MP0002733_abnormal_thermal_nociception	0.68722208
96	MP0003111_abnormal_nucleus_morphology	0.68595196
97	MP0002735_abnormal_chemical_nociception	0.68347302
98	MP0003137_abnormal_impulse_conducting	0.67402028
99	MP0008469_abnormal_protein_level	0.67398971
100	MP0005391_vision/eye_phenotype	0.67089372

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	3.77980883
2	Acute necrotizing encephalopathy (HP:0006965)	3.52860249
3	Mitochondrial inheritance (HP:0001427)	3.46641312
4	Hepatocellular necrosis (HP:0001404)	3.28777191
5	Increased CSF lactate (HP:0002490)	3.27278796
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.21729611
7	3-Methylglutaconic aciduria (HP:0003535)	3.21579764
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.13595675
9	Acute encephalopathy (HP:0006846)	3.11949015
10	Pancreatic cysts (HP:0001737)	3.10652686
11	Abnormal glycosylation (HP:0012345)	3.08455223
12	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.08455223
13	Abnormal protein N-linked glycosylation (HP:0012347)	3.08455223
14	Abnormal protein glycosylation (HP:0012346)	3.08455223
15	Abolished electroretinogram (ERG) (HP:0000550)	3.05646292
16	Severe combined immunodeficiency (HP:0004430)	2.95022259
17	Type I transferrin isoform profile (HP:0003642)	2.92995869
18	Progressive macrocephaly (HP:0004481)	2.89545502
19	Hepatic necrosis (HP:0002605)	2.88414208
20	Increased serum lactate (HP:0002151)	2.81877054
21	Aplasia/hypoplasia of the uterus (HP:0008684)	2.79061002
22	Delayed CNS myelination (HP:0002188)	2.78864593
23	Methylmalonic acidemia (HP:0002912)	2.75757552
24	Lactic acidosis (HP:0003128)	2.71067361
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.68040299
26	Abnormality of alanine metabolism (HP:0010916)	2.66204508
27	Hyperalaninemia (HP:0003348)	2.66204508
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.66204508
29	Optic disc pallor (HP:0000543)	2.64813852
30	Attenuation of retinal blood vessels (HP:0007843)	2.64086080
31	Cerebral edema (HP:0002181)	2.63591782
32	Increased hepatocellular lipid droplets (HP:0006565)	2.61363304
33	Abnormality of the prostate (HP:0008775)	2.60445380
34	Renal Fanconi syndrome (HP:0001994)	2.54586793
35	Retinal dysplasia (HP:0007973)	2.47015112
36	Methylmalonic aciduria (HP:0012120)	2.46172399
37	Type 2 muscle fiber atrophy (HP:0003554)	2.43564039
38	Pendular nystagmus (HP:0012043)	2.42640067
39	True hermaphroditism (HP:0010459)	2.40926247
40	Lissencephaly (HP:0001339)	2.40423426
41	Hyperglycinemia (HP:0002154)	2.38316666
42	Lipid accumulation in hepatocytes (HP:0006561)	2.36915686
43	Increased corneal curvature (HP:0100692)	2.34300750
44	Keratoconus (HP:0000563)	2.34300750
45	Renal cortical cysts (HP:0000803)	2.33556721
46	Fibular aplasia (HP:0002990)	2.33006828
47	Cerebral palsy (HP:0100021)	2.31770756
48	Constricted visual fields (HP:0001133)	2.31365113
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.31099216
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30331389
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30331389
52	Abnormality of eosinophils (HP:0001879)	2.30322747
53	Congenital stationary night blindness (HP:0007642)	2.30271158
54	Short tibia (HP:0005736)	2.29555473
55	Type II lissencephaly (HP:0007260)	2.27063426
56	Increased intramyocellular lipid droplets (HP:0012240)	2.26268285
57	Combined immunodeficiency (HP:0005387)	2.24523684
58	Hypoproteinemia (HP:0003075)	2.23788856
59	Carpal bone hypoplasia (HP:0001498)	2.16069911
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15405839
61	Pancreatic fibrosis (HP:0100732)	2.14841641
62	Hypoplasia of the uterus (HP:0000013)	2.13606459
63	Progressive microcephaly (HP:0000253)	2.13587100
64	Generalized aminoaciduria (HP:0002909)	2.13057469
65	Decreased central vision (HP:0007663)	2.13035520
66	Stomach cancer (HP:0012126)	2.13025971
67	Abnormality of glycine metabolism (HP:0010895)	2.12903708
68	Abnormality of serine family amino acid metabolism (HP:0010894)	2.12903708
69	Amyotrophic lateral sclerosis (HP:0007354)	2.12641800
70	Muscle fiber atrophy (HP:0100295)	2.10773396
71	Opisthotonus (HP:0002179)	2.09366361
72	Molar tooth sign on MRI (HP:0002419)	2.09359472
73	Abnormality of midbrain morphology (HP:0002418)	2.09359472
74	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08481992
75	T lymphocytopenia (HP:0005403)	2.08367664
76	Dicarboxylic aciduria (HP:0003215)	2.08112380
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.08112380
78	Reduced antithrombin III activity (HP:0001976)	2.05509329
79	Abnormality of T cell number (HP:0011839)	2.05481695
80	IgM deficiency (HP:0002850)	2.04358570
81	Abnormality of serum amino acid levels (HP:0003112)	1.98924078
82	Exercise intolerance (HP:0003546)	1.97279729
83	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.97182531
84	Lethargy (HP:0001254)	1.96321030
85	Eosinophilia (HP:0001880)	1.92661609
86	Emotional lability (HP:0000712)	1.92202861
87	Medial flaring of the eyebrow (HP:0010747)	1.91386599
88	Abnormality of T cells (HP:0002843)	1.89759722
89	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89371380
90	Nephronophthisis (HP:0000090)	1.89179742
91	Pancytopenia (HP:0001876)	1.87842458
92	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.86839846
93	Adactyly (HP:0009776)	1.86588334
94	Cerebellar dysplasia (HP:0007033)	1.83845164
95	Increased IgM level (HP:0003496)	1.81924749
96	Respiratory failure (HP:0002878)	1.79717900
97	Progressive inability to walk (HP:0002505)	1.79612607
98	Hyperglycinuria (HP:0003108)	1.76770216
99	Thyroiditis (HP:0100646)	1.76747893
100	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.75982105

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.65139469
2	MAP4K2	4.20367648
3	TXK	3.62171628
4	BCKDK	3.53705204
5	VRK2	2.71516961
6	KDR	2.60586001
7	SRPK1	2.46974274
8	TAOK3	2.36786465
9	BCR	2.07228783
10	NUAK1	2.03031983
11	SCYL2	2.00364991
12	ZAK	1.98310355
13	LIMK1	1.97612312
14	MAP2K7	1.87469206
15	TRIM28	1.84102599
16	CSNK1G3	1.71940034
17	TESK1	1.71418394
18	TLK1	1.56117024
19	TIE1	1.52428954
20	GRK6	1.49375202
21	GRK1	1.48456195
22	CSNK1A1L	1.47340768
23	EIF2AK3	1.43336874
24	CDK19	1.43045562
25	ERBB3	1.42131628
26	MAP3K4	1.42127827
27	CSNK1G2	1.34706121
28	DAPK1	1.25975647
29	MAPKAPK3	1.24807624
30	WNK3	1.22719336
31	CSNK1G1	1.22499122
32	VRK1	1.20090751
33	TBK1	1.17947643
34	STK16	1.17384910
35	PIM2	1.17128563
36	MAP3K14	1.07664018
37	RPS6KA4	1.07438439
38	NEK1	1.04637571
39	MATK	1.04632332
40	IKBKE	1.03622723
41	ADRBK2	1.00181068
42	EIF2AK2	0.92243840
43	BUB1	0.91983089
44	ITK	0.91152826
45	TEC	0.90585545
46	PHKG1	0.90181195
47	PHKG2	0.90181195
48	FLT3	0.88815677
49	MAP2K2	0.88354815
50	RPS6KA5	0.85100300
51	IKBKB	0.84719670
52	MAPK13	0.84261777
53	EPHA3	0.83992700
54	CSF1R	0.83671686
55	DYRK2	0.81651130
56	KIT	0.79306721
57	TSSK6	0.79002289
58	MKNK1	0.76059764
59	CCNB1	0.75197633
60	AURKA	0.72573981
61	BMPR1B	0.71815332
62	FES	0.71765095
63	PLK4	0.71029469
64	OXSR1	0.69514676
65	SIK2	0.61967167
66	MAP4K1	0.61657577
67	MARK1	0.61256284
68	PINK1	0.60605988
69	LCK	0.56153290
70	SYK	0.54038904
71	WNK4	0.51161774
72	LYN	0.50779724
73	JAK3	0.50287666
74	TAF1	0.49205268
75	INSRR	0.48113826
76	CAMKK2	0.46547623
77	ATR	0.45595971
78	GRK7	0.45290617
79	SIK3	0.45236104
80	MAPKAPK5	0.45222650
81	GRK5	0.44354171
82	IGF1R	0.43916600
83	AURKB	0.43407024
84	DYRK1B	0.41664235
85	PLK3	0.41313852
86	LMTK2	0.39107227
87	ACVR1B	0.38216480
88	MAP3K5	0.38089011
89	ABL1	0.37452979
90	MST4	0.37132977
91	PRKCQ	0.36740968
92	FRK	0.35780287
93	ARAF	0.33109557
94	CSNK2A1	0.33068803
95	PLK2	0.33064927
96	PKN1	0.31628024
97	PIK3CG	0.31577463
98	BTK	0.30732336
99	PAK6	0.30535976
100	CSNK1A1	0.27831621

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.07580111
2	RNA polymerase_Homo sapiens_hsa03020	2.46122922
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34327006
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.33008031
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21068804
6	Protein export_Homo sapiens_hsa03060	1.94357277
7	Base excision repair_Homo sapiens_hsa03410	1.93183984
8	Graft-versus-host disease_Homo sapiens_hsa05332	1.92061572
9	Parkinsons disease_Homo sapiens_hsa05012	1.91278282
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.90206588
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85138287
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.80840515
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79610821
14	Allograft rejection_Homo sapiens_hsa05330	1.78761108
15	Asthma_Homo sapiens_hsa05310	1.77731109
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74571130
17	Spliceosome_Homo sapiens_hsa03040	1.72356896
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.65220404
19	Phototransduction_Homo sapiens_hsa04744	1.64532344
20	DNA replication_Homo sapiens_hsa03030	1.63696472
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60789046
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.59561674
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59417350
24	Sulfur metabolism_Homo sapiens_hsa00920	1.58260721
25	Basal transcription factors_Homo sapiens_hsa03022	1.53836299
26	Homologous recombination_Homo sapiens_hsa03440	1.52929669
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.52714361
28	One carbon pool by folate_Homo sapiens_hsa00670	1.52583141
29	RNA degradation_Homo sapiens_hsa03018	1.48240559
30	Propanoate metabolism_Homo sapiens_hsa00640	1.46844290
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46648858
32	Mismatch repair_Homo sapiens_hsa03430	1.46082474
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45935374
34	Fatty acid elongation_Homo sapiens_hsa00062	1.45127180
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39708134
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33100573
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.31379050
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31226630
39	Sulfur relay system_Homo sapiens_hsa04122	1.30541461
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25321204
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.24404800
42	RNA transport_Homo sapiens_hsa03013	1.24090782
43	Peroxisome_Homo sapiens_hsa04146	1.21685272
44	Purine metabolism_Homo sapiens_hsa00230	1.18894634
45	Selenocompound metabolism_Homo sapiens_hsa00450	1.18288458
46	Butanoate metabolism_Homo sapiens_hsa00650	1.17664457
47	Regulation of autophagy_Homo sapiens_hsa04140	1.15309975
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15261358
49	Huntingtons disease_Homo sapiens_hsa05016	1.10806126
50	Nucleotide excision repair_Homo sapiens_hsa03420	1.09216661
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08022155
52	Alzheimers disease_Homo sapiens_hsa05010	1.02725240
53	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.94851498
54	Viral myocarditis_Homo sapiens_hsa05416	0.94199373
55	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91453349
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86374084
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.86132265
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84724041
59	Shigellosis_Homo sapiens_hsa05131	0.84399101
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84255876
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.81826026
62	Herpes simplex infection_Homo sapiens_hsa05168	0.79118742
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79029900
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75538660
65	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.75363042
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.75042769
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74177654
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73780939
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.69148823
70	Caffeine metabolism_Homo sapiens_hsa00232	0.69117819
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67580272
72	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.66825429
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65674937
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65415245
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.65022468
76	Metabolic pathways_Homo sapiens_hsa01100	0.64026016
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61757842
78	Carbon metabolism_Homo sapiens_hsa01200	0.60856851
79	Ribosome_Homo sapiens_hsa03010	0.60273220
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58221357
81	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55608541
82	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.55279945
83	Nicotine addiction_Homo sapiens_hsa05033	0.53791150
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52543266
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51547997
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.50007481
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49446539
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49299239
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.46358020
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45865219
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45625028
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45504620
93	Olfactory transduction_Homo sapiens_hsa04740	0.43495308
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.42983491
95	Legionellosis_Homo sapiens_hsa05134	0.42505238
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42147828
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39914690
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39087238
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38947633
100	GABAergic synapse_Homo sapiens_hsa04727	0.38038082

EIF4A1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »