EIF4A1P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)6.99647099
2platelet dense granule organization (GO:0060155)6.20596973
3regulation of cell communication by electrical coupling (GO:0010649)6.12828721
4response to pheromone (GO:0019236)6.11210115
5regulation of action potential (GO:0098900)4.96212486
6negative regulation of sodium ion transport (GO:0010766)4.87360205
7protein neddylation (GO:0045116)4.79867807
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64206066
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44554290
10ATP synthesis coupled proton transport (GO:0015986)4.44554290
11forebrain neuron differentiation (GO:0021879)4.29263618
12keratinocyte development (GO:0003334)4.29168037
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13068221
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.10842957
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.10842957
16pseudouridine synthesis (GO:0001522)4.07108878
17neural tube formation (GO:0001841)4.04276625
18metallo-sulfur cluster assembly (GO:0031163)3.86886094
19iron-sulfur cluster assembly (GO:0016226)3.86886094
20sequestering of actin monomers (GO:0042989)3.78056355
21respiratory chain complex IV assembly (GO:0008535)3.77371545
22proteasome assembly (GO:0043248)3.75664951
23respiratory electron transport chain (GO:0022904)3.70256785
24relaxation of cardiac muscle (GO:0055119)3.66974406
25electron transport chain (GO:0022900)3.66667364
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.61178160
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.61037514
28adaptation of signaling pathway (GO:0023058)3.60949970
29axoneme assembly (GO:0035082)3.55862930
30intraciliary transport (GO:0042073)3.38926046
31ubiquinone biosynthetic process (GO:0006744)3.36239882
32cytochrome complex assembly (GO:0017004)3.34268020
33fat-soluble vitamin biosynthetic process (GO:0042362)3.33900489
34S-adenosylmethionine metabolic process (GO:0046500)3.32853558
35DNA deamination (GO:0045006)3.30962606
36ubiquinone metabolic process (GO:0006743)3.28747989
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25194252
38cytidine metabolic process (GO:0046087)3.21410274
39cytidine catabolic process (GO:0006216)3.21410274
40cytidine deamination (GO:0009972)3.21410274
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.18344010
42isoprenoid biosynthetic process (GO:0008299)3.14311999
43chaperone-mediated protein transport (GO:0072321)3.11272097
44auditory receptor cell differentiation (GO:0042491)3.09139295
45preassembly of GPI anchor in ER membrane (GO:0016254)3.06603813
46anterograde synaptic vesicle transport (GO:0048490)3.05616415
47protein localization to cilium (GO:0061512)3.00968987
48regulation of heart rate by cardiac conduction (GO:0086091)2.97526531
49purine deoxyribonucleotide catabolic process (GO:0009155)2.96482024
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94602598
51regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93779857
52forebrain morphogenesis (GO:0048853)2.92863024
53detection of light stimulus involved in sensory perception (GO:0050962)2.92787201
54detection of light stimulus involved in visual perception (GO:0050908)2.92787201
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82190043
56quinone biosynthetic process (GO:1901663)2.81962061
57fat-soluble vitamin catabolic process (GO:0042363)2.79757533
58vitamin catabolic process (GO:0009111)2.79757533
59actin nucleation (GO:0045010)2.78927937
60protein complex biogenesis (GO:0070271)2.76312915
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75322377
62peptidyl-cysteine modification (GO:0018198)2.74612679
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73250496
64ATP biosynthetic process (GO:0006754)2.72162679
65fucose catabolic process (GO:0019317)2.71722661
66L-fucose metabolic process (GO:0042354)2.71722661
67L-fucose catabolic process (GO:0042355)2.71722661
68mismatch repair (GO:0006298)2.71716390
69protein targeting to mitochondrion (GO:0006626)2.69109146
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68666318
71establishment of protein localization to mitochondrion (GO:0072655)2.67071955
72epithelial cilium movement (GO:0003351)2.66810958
73regulation of cellular amino acid metabolic process (GO:0006521)2.66466292
74hydrogen ion transmembrane transport (GO:1902600)2.64712290
75cornea development in camera-type eye (GO:0061303)2.64254955
76C-terminal protein amino acid modification (GO:0018410)2.64148172
77lactate metabolic process (GO:0006089)2.63454220
78cullin deneddylation (GO:0010388)2.63328599
79glial cell proliferation (GO:0014009)2.62825353
80somite rostral/caudal axis specification (GO:0032525)2.60803627
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59093373
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59093373
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59093373
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58434046
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58434046
86behavioral response to nicotine (GO:0035095)2.57239322
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.56800863
88catecholamine transport (GO:0051937)2.56532903
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.55933965
90positive regulation of fatty acid beta-oxidation (GO:0032000)2.54823033
91proton transport (GO:0015992)2.54569900
92protein K11-linked ubiquitination (GO:0070979)2.54150748
93mitochondrial respiratory chain complex assembly (GO:0033108)2.54008559
94hindbrain development (GO:0030902)2.52299114
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52176649
96retinal cone cell development (GO:0046549)2.51049916
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51017132
98DNA double-strand break processing (GO:0000729)2.49670317
99negative regulation of protein oligomerization (GO:0032460)2.49517796
100meiotic chromosome segregation (GO:0045132)2.49437878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.75550690
2IGF1R_20145208_ChIP-Seq_DFB_Human3.79469661
3VDR_22108803_ChIP-Seq_LS180_Human3.42672757
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.22025348
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17747120
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13586336
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61400620
8ZNF274_21170338_ChIP-Seq_K562_Hela2.60913869
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37836951
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.34527053
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.30095446
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21226997
13ELK1_19687146_ChIP-ChIP_HELA_Human2.19116196
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18167807
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18126046
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17508142
17VDR_23849224_ChIP-Seq_CD4+_Human2.13499056
18EWS_26573619_Chip-Seq_HEK293_Human2.12964461
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.07600662
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.06607235
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05809102
22P300_19829295_ChIP-Seq_ESCs_Human1.91934121
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77484967
24MYC_18940864_ChIP-ChIP_HL60_Human1.76204373
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73529597
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72524971
27TP53_22573176_ChIP-Seq_HFKS_Human1.68934914
28IRF1_19129219_ChIP-ChIP_H3396_Human1.68609157
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66884383
30FOXP3_21729870_ChIP-Seq_TREG_Human1.65079565
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56619376
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48165413
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.44287821
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43236710
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43211723
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.41027684
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40428831
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40282109
39CBP_20019798_ChIP-Seq_JUKART_Human1.40282109
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37753873
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36443791
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35591371
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.34280324
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31601370
45FUS_26573619_Chip-Seq_HEK293_Human1.30686310
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30661328
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30226844
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.30226844
49NANOG_19829295_ChIP-Seq_ESCs_Human1.28631770
50SOX2_19829295_ChIP-Seq_ESCs_Human1.28631770
51AR_20517297_ChIP-Seq_VCAP_Human1.27847838
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.26395236
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.24483604
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.22896600
55HOXB7_26014856_ChIP-Seq_BT474_Human1.20973940
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.16131117
57BCAT_22108803_ChIP-Seq_LS180_Human1.14938918
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14590558
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.14556674
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14537957
61ETV1_20927104_ChIP-Seq_GIST48_Human1.13914264
62GABP_19822575_ChIP-Seq_HepG2_Human1.13898212
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13122951
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12914905
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12541759
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12296651
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08631600
68RUNX2_22187159_ChIP-Seq_PCA_Human1.08135147
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07520783
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06372834
71RBPJ_21746931_ChIP-Seq_IB4_Human1.06230634
72NCOR_22424771_ChIP-Seq_293T_Human1.05913105
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.05716237
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05555136
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05475846
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.04387854
77TAF15_26573619_Chip-Seq_HEK293_Human1.03024649
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.03016542
79GBX2_23144817_ChIP-Seq_PC3_Human1.02302988
80CDX2_22108803_ChIP-Seq_LS180_Human1.01895922
81ERA_21632823_ChIP-Seq_H3396_Human1.01894799
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.01860352
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01836380
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01369478
85P53_22387025_ChIP-Seq_ESCs_Mouse1.01233172
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01128016
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00178938
88TCF4_22108803_ChIP-Seq_LS180_Human0.99834917
89P300_18555785_Chip-Seq_ESCs_Mouse0.99211527
90RNF2_27304074_Chip-Seq_NSC_Mouse0.98300574
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96871054
92AR_25329375_ChIP-Seq_VCAP_Human0.96087518
93PHF8_20622853_ChIP-Seq_HELA_Human0.96011054
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95370295
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.95325190
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95047305
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93823479
98NANOG_20526341_ChIP-Seq_ESCs_Human0.93580227
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92296472
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91915975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.88353288
2MP0008995_early_reproductive_senescence3.38523478
3MP0002736_abnormal_nociception_after3.30860572
4MP0002254_reproductive_system_inflammat3.22295146
5MP0005645_abnormal_hypothalamus_physiol3.17011779
6MP0001968_abnormal_touch/_nociception3.13586619
7MP0002102_abnormal_ear_morphology2.90014272
8MP0003880_abnormal_central_pattern2.57754111
9MP0006054_spinal_hemorrhage2.18722450
10MP0006292_abnormal_olfactory_placode2.14095639
11MP0003122_maternal_imprinting2.09067957
12MP0005075_abnormal_melanosome_morpholog2.07371476
13MP0002837_dystrophic_cardiac_calcinosis2.05595642
14MP0004133_heterotaxia2.02203637
15MP0005551_abnormal_eye_electrophysiolog1.99701496
16MP0002653_abnormal_ependyma_morphology1.97817067
17MP0005253_abnormal_eye_physiology1.96399581
18MP0003121_genomic_imprinting1.90807787
19MP0006276_abnormal_autonomic_nervous1.90341750
20MP0008057_abnormal_DNA_replication1.87048948
21MP0006072_abnormal_retinal_apoptosis1.84559136
22MP0003787_abnormal_imprinting1.80783326
23MP0000372_irregular_coat_pigmentation1.77116844
24MP0005084_abnormal_gallbladder_morpholo1.71372299
25MP0008872_abnormal_physiological_respon1.67984758
26MP0005174_abnormal_tail_pigmentation1.64169829
27MP0000647_abnormal_sebaceous_gland1.61410525
28MP0003718_maternal_effect1.61119919
29MP0001984_abnormal_olfaction1.60471617
30MP0000427_abnormal_hair_cycle1.57900628
31MP0006035_abnormal_mitochondrial_morpho1.56050798
32MP0003890_abnormal_embryonic-extraembry1.51944828
33MP0002272_abnormal_nervous_system1.50996891
34MP0003786_premature_aging1.50584820
35MP0001485_abnormal_pinna_reflex1.49990267
36MP0003137_abnormal_impulse_conducting1.48141543
37MP0002928_abnormal_bile_duct1.46014364
38MP0003195_calcinosis1.40261038
39MP0008961_abnormal_basal_metabolism1.39883872
40MP0003136_yellow_coat_color1.36288910
41MP0001986_abnormal_taste_sensitivity1.35869437
42MP0005423_abnormal_somatic_nervous1.33953501
43MP0002095_abnormal_skin_pigmentation1.30307896
44MP0004145_abnormal_muscle_electrophysio1.27877963
45MP0002090_abnormal_vision1.26514377
46MP0005636_abnormal_mineral_homeostasis1.25350744
47MP0005083_abnormal_biliary_tract1.24915583
48MP0008875_abnormal_xenobiotic_pharmacok1.24735684
49MP0003567_abnormal_fetal_cardiomyocyte1.20088146
50MP0000569_abnormal_digit_pigmentation1.17859638
51MP0002751_abnormal_autonomic_nervous1.16683868
52MP0009046_muscle_twitch1.16105624
53MP0000631_abnormal_neuroendocrine_gland1.16101724
54MP0002938_white_spotting1.10658621
55MP0002234_abnormal_pharynx_morphology1.09713010
56MP0000778_abnormal_nervous_system1.09250782
57MP0009745_abnormal_behavioral_response1.07995019
58MP0005410_abnormal_fertilization1.05713634
59MP0004381_abnormal_hair_follicle1.04543854
60MP0006036_abnormal_mitochondrial_physio1.02325588
61MP0002752_abnormal_somatic_nervous0.97822713
62MP0004484_altered_response_of0.96764670
63MP0000015_abnormal_ear_pigmentation0.95547912
64MP0003646_muscle_fatigue0.91838008
65MP0005670_abnormal_white_adipose0.91172999
66MP0005365_abnormal_bile_salt0.90509632
67MP0004043_abnormal_pH_regulation0.89686983
68MP0004019_abnormal_vitamin_homeostasis0.88678062
69MP0000639_abnormal_adrenal_gland0.88019589
70MP0002184_abnormal_innervation0.87989258
71MP0005671_abnormal_response_to0.87908062
72MP0003252_abnormal_bile_duct0.87098200
73MP0001486_abnormal_startle_reflex0.86318942
74MP0004085_abnormal_heartbeat0.86011618
75MP0004742_abnormal_vestibular_system0.85673075
76MP0008058_abnormal_DNA_repair0.84294607
77MP0003011_delayed_dark_adaptation0.83857188
78MP0002735_abnormal_chemical_nociception0.78413599
79MP0003186_abnormal_redox_activity0.77897973
80MP0001970_abnormal_pain_threshold0.77216654
81MP0005391_vision/eye_phenotype0.73440606
82MP0001188_hyperpigmentation0.73338959
83MP0001765_abnormal_ion_homeostasis0.73258482
84MP0002138_abnormal_hepatobiliary_system0.73188320
85MP0001529_abnormal_vocalization0.72894298
86MP0008789_abnormal_olfactory_epithelium0.71295073
87MP0002229_neurodegeneration0.71257876
88MP0001324_abnormal_eye_pigmentation0.71066050
89MP0001119_abnormal_female_reproductive0.70969369
90MP0003693_abnormal_embryo_hatching0.70370356
91MP0002557_abnormal_social/conspecific_i0.68644889
92MP0003119_abnormal_digestive_system0.68449820
93MP0004215_abnormal_myocardial_fiber0.68402598
94MP0002693_abnormal_pancreas_physiology0.68186735
95MP0000955_abnormal_spinal_cord0.67697260
96MP0002572_abnormal_emotion/affect_behav0.66792138
97MP0001666_abnormal_nutrient_absorption0.66209281
98MP0001501_abnormal_sleep_pattern0.64973525
99MP0003950_abnormal_plasma_membrane0.64768686
100MP0005266_abnormal_metabolism0.63648272

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.10489333
2Acute encephalopathy (HP:0006846)4.04484685
3Pancreatic cysts (HP:0001737)4.00175283
4Abnormal mitochondria in muscle tissue (HP:0008316)3.65459411
5Pancreatic fibrosis (HP:0100732)3.62119223
6Mitochondrial inheritance (HP:0001427)3.60161343
7Increased CSF lactate (HP:0002490)3.57393455
8Progressive macrocephaly (HP:0004481)3.33466352
9Hepatocellular necrosis (HP:0001404)3.30239947
10Congenital stationary night blindness (HP:0007642)3.25915636
11Facial diplegia (HP:0001349)3.22895177
12Hyperglycinemia (HP:0002154)3.18984365
13Abnormality of midbrain morphology (HP:0002418)3.17795293
14Molar tooth sign on MRI (HP:0002419)3.17795293
15True hermaphroditism (HP:0010459)3.11728242
16Severe combined immunodeficiency (HP:0004430)3.06836111
17Cerebral edema (HP:0002181)3.01324787
18Nephronophthisis (HP:0000090)2.96427021
19Amyotrophic lateral sclerosis (HP:0007354)2.92842331
20Retinal atrophy (HP:0001105)2.84734430
21Decreased central vision (HP:0007663)2.84648154
22Generalized aminoaciduria (HP:0002909)2.77232179
23Hepatic necrosis (HP:0002605)2.74830248
24Abnormality of the renal medulla (HP:0100957)2.70946766
25Progressive inability to walk (HP:0002505)2.66970252
26Intestinal atresia (HP:0011100)2.65276058
27Type II lissencephaly (HP:0007260)2.64441666
28Symptomatic seizures (HP:0011145)2.64215422
29Thyroiditis (HP:0100646)2.63905733
30Increased hepatocellular lipid droplets (HP:0006565)2.63499794
31Hypomagnesemia (HP:0002917)2.54472862
32Lipid accumulation in hepatocytes (HP:0006561)2.53587872
33Abnormality of the lower motor neuron (HP:0002366)2.45359433
34Microretrognathia (HP:0000308)2.44718587
35Cystic liver disease (HP:0006706)2.43088450
36X-linked dominant inheritance (HP:0001423)2.42652045
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.31885935
38Congenital malformation of the right heart (HP:0011723)2.27545057
39Double outlet right ventricle (HP:0001719)2.27545057
40Cerebral hypomyelination (HP:0006808)2.27330689
41Lactic acidosis (HP:0003128)2.25856689
42Hyperglycinuria (HP:0003108)2.25830287
43Renal Fanconi syndrome (HP:0001994)2.24913787
44Lethargy (HP:0001254)2.22259111
45Hypoproteinemia (HP:0003075)2.21873820
46Tubular atrophy (HP:0000092)2.21305452
47Increased serum lactate (HP:0002151)2.19952493
48Tetany (HP:0001281)2.18292819
49Short tibia (HP:0005736)2.17293306
50Abnormality of serine family amino acid metabolism (HP:0010894)2.16116686
51Abnormality of glycine metabolism (HP:0010895)2.16116686
52Combined immunodeficiency (HP:0005387)2.15972116
53Chronic hepatic failure (HP:0100626)2.13178564
54Respiratory failure (HP:0002878)2.12066093
55Large for gestational age (HP:0001520)2.11832694
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09388441
57Abnormality of alanine metabolism (HP:0010916)2.09388441
58Hyperalaninemia (HP:0003348)2.09388441
59Inability to walk (HP:0002540)2.08391207
60Abnormality of B cell number (HP:0010975)2.08027303
61Delusions (HP:0000746)2.06384079
62Inappropriate behavior (HP:0000719)2.04008231
63Sclerocornea (HP:0000647)2.03622786
64CNS hypomyelination (HP:0003429)2.01493683
65Optic disc pallor (HP:0000543)2.00407288
66Pancreatic islet-cell hyperplasia (HP:0004510)1.99332494
67Methylmalonic acidemia (HP:0002912)1.98906257
68Hyperventilation (HP:0002883)1.98428418
69Abnormality of magnesium homeostasis (HP:0004921)1.97567232
70Respiratory difficulties (HP:0002880)1.96002089
71Colon cancer (HP:0003003)1.92224478
72Abnormality of serum amino acid levels (HP:0003112)1.91658269
73Tubulointerstitial nephritis (HP:0001970)1.91462186
74Flat occiput (HP:0005469)1.89821187
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89208483
76CNS demyelination (HP:0007305)1.89159723
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.88087180
78Enlarged epiphyses (HP:0010580)1.87474791
79Abnormal drinking behavior (HP:0030082)1.87148996
80Polydipsia (HP:0001959)1.87148996
81Increased intramyocellular lipid droplets (HP:0012240)1.87131432
82Dandy-Walker malformation (HP:0001305)1.84394909
83Mesangial abnormality (HP:0001966)1.84300171
84Postaxial foot polydactyly (HP:0001830)1.82586923
85Parakeratosis (HP:0001036)1.81506660
86Small hand (HP:0200055)1.80441710
87Lissencephaly (HP:0001339)1.79801130
88Preaxial hand polydactyly (HP:0001177)1.79393565
89Long nose (HP:0003189)1.78931385
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78276906
913-Methylglutaconic aciduria (HP:0003535)1.77646715
92Fair hair (HP:0002286)1.76668603
93Abnormality of urine glucose concentration (HP:0011016)1.75640115
94Glycosuria (HP:0003076)1.75640115
95Oligodactyly (hands) (HP:0001180)1.73518836
96Neonatal respiratory distress (HP:0002643)1.72760134
97Ketosis (HP:0001946)1.70118140
98Pendular nystagmus (HP:0012043)1.70007557
99B lymphocytopenia (HP:0010976)1.68723676
100Male pseudohermaphroditism (HP:0000037)1.67520400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.75565923
2MAP4K24.44858457
3MST43.40299706
4BCR2.86663752
5GRK12.54131483
6SIK32.53694309
7KDR2.44692661
8STK162.35860107
9PINK12.34755623
10BCKDK2.27375514
11FRK2.08119435
12PIK3CA1.95530962
13WNK41.92254519
14ERBB41.91161580
15WNK31.90522811
16PLK21.62869754
17ADRBK21.60745919
18EIF2AK31.53295708
19PAK31.50945550
20SRPK11.47608268
21AKT31.39480008
22PDK21.26241383
23ZAK1.25556377
24MINK11.24530409
25RPS6KB11.18829742
26INSRR1.14948861
27BUB11.13015205
28MARK11.09435296
29CSNK1G31.09396572
30CAMK2D1.08714564
31NME11.07325880
32MAPK131.05917857
33CSNK1G21.05525153
34NEK11.00214558
35MAP3K120.99396929
36STK30.99235024
37DYRK20.98738461
38TESK20.98016694
39CSNK1G10.95013542
40VRK10.94651430
41NUAK10.94007447
42CSNK1A1L0.93454648
43VRK20.89878493
44WEE10.89832010
45TESK10.88601615
46OXSR10.86913319
47LIMK10.86156764
48STK390.85398174
49TIE10.85031692
50PHKG10.79364660
51PHKG20.79364660
52BRSK20.78861563
53STK100.77804568
54STK40.77530093
55PRKCI0.76303896
56CDK190.76199997
57PRKCE0.75611407
58ACVR1B0.74283447
59PTK2B0.73504125
60PLK30.72662947
61RPS6KA40.70035250
62BMPR1B0.69236222
63TNK20.67626795
64MAP2K70.67216013
65PRKCG0.66307738
66MAP4K10.66258632
67ADRBK10.65305515
68TLK10.63504282
69CASK0.60650738
70PLK10.59763123
71FES0.59382031
72OBSCN0.59322025
73STK38L0.57743473
74MKNK10.57217457
75ICK0.55608242
76BRAF0.54334046
77MKNK20.50642467
78TNIK0.50280238
79RPS6KA50.49677335
80CSNK1A10.47435067
81TEC0.46589025
82NTRK20.45978303
83PLK40.44218294
84CDK30.44130350
85PRKG10.44081666
86NEK20.43494910
87GRK50.42183194
88PRKACA0.40439319
89ATR0.39978703
90CAMK2A0.39726315
91EPHB20.39340815
92PBK0.38375669
93PRKCQ0.38050075
94PRKCB0.37726116
95CSNK2A10.36653438
96CSF1R0.35709153
97CSNK1E0.34705519
98TXK0.34118121
99RIPK40.33423754
100NLK0.31959051

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.91337902
2Proteasome_Homo sapiens_hsa030503.65394901
3Parkinsons disease_Homo sapiens_hsa050123.22562474
4Steroid biosynthesis_Homo sapiens_hsa001002.64524032
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58223113
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46034419
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43922842
8Protein export_Homo sapiens_hsa030602.43893490
9Homologous recombination_Homo sapiens_hsa034402.26663320
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26577472
11RNA polymerase_Homo sapiens_hsa030202.20417849
12Huntingtons disease_Homo sapiens_hsa050162.17731281
13Alzheimers disease_Homo sapiens_hsa050102.07177677
14Butanoate metabolism_Homo sapiens_hsa006501.89208630
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80722885
16Basal transcription factors_Homo sapiens_hsa030221.78771625
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78354108
18Propanoate metabolism_Homo sapiens_hsa006401.70501425
19Phototransduction_Homo sapiens_hsa047441.70000719
20Non-homologous end-joining_Homo sapiens_hsa034501.63392852
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62336213
22Cardiac muscle contraction_Homo sapiens_hsa042601.59132609
23Fatty acid elongation_Homo sapiens_hsa000621.54711512
24Selenocompound metabolism_Homo sapiens_hsa004501.54499544
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43804522
26Sulfur relay system_Homo sapiens_hsa041221.42800497
27Primary immunodeficiency_Homo sapiens_hsa053401.42428382
28Olfactory transduction_Homo sapiens_hsa047401.41142970
29Mismatch repair_Homo sapiens_hsa034301.40568698
30Peroxisome_Homo sapiens_hsa041461.37153776
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36791883
32Fanconi anemia pathway_Homo sapiens_hsa034601.27943814
33Linoleic acid metabolism_Homo sapiens_hsa005911.25780429
34Caffeine metabolism_Homo sapiens_hsa002321.21327638
35RNA degradation_Homo sapiens_hsa030181.19853504
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.14950510
37Tryptophan metabolism_Homo sapiens_hsa003801.12096129
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09953744
39RNA transport_Homo sapiens_hsa030131.08727192
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99629311
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95272341
42Nucleotide excision repair_Homo sapiens_hsa034200.94841084
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93895556
44Spliceosome_Homo sapiens_hsa030400.91977995
45ABC transporters_Homo sapiens_hsa020100.90501974
46Ribosome_Homo sapiens_hsa030100.90237526
47Fatty acid degradation_Homo sapiens_hsa000710.89455409
48Amphetamine addiction_Homo sapiens_hsa050310.87687200
49Fat digestion and absorption_Homo sapiens_hsa049750.85184258
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84332538
51Regulation of autophagy_Homo sapiens_hsa041400.84275582
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82737990
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80992253
54Retinol metabolism_Homo sapiens_hsa008300.80084121
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79567849
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79365363
57Pyrimidine metabolism_Homo sapiens_hsa002400.78510325
58Metabolic pathways_Homo sapiens_hsa011000.76299973
59Insulin secretion_Homo sapiens_hsa049110.75514115
60Ether lipid metabolism_Homo sapiens_hsa005650.75401439
61Purine metabolism_Homo sapiens_hsa002300.74948846
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.74653754
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74620655
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73132310
65Nitrogen metabolism_Homo sapiens_hsa009100.72594951
66Glutathione metabolism_Homo sapiens_hsa004800.70085255
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68850556
68Oocyte meiosis_Homo sapiens_hsa041140.68329600
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.66054106
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64553174
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64386619
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64379751
73beta-Alanine metabolism_Homo sapiens_hsa004100.63251264
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61239536
75Circadian entrainment_Homo sapiens_hsa047130.61176597
76Chemical carcinogenesis_Homo sapiens_hsa052040.61057096
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.60684526
78Nicotine addiction_Homo sapiens_hsa050330.55043310
79Collecting duct acid secretion_Homo sapiens_hsa049660.54297066
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53610472
81Sulfur metabolism_Homo sapiens_hsa009200.48289866
82Arachidonic acid metabolism_Homo sapiens_hsa005900.48083706
83Shigellosis_Homo sapiens_hsa051310.45293746
84Type I diabetes mellitus_Homo sapiens_hsa049400.45130086
85DNA replication_Homo sapiens_hsa030300.44779531
86Fatty acid metabolism_Homo sapiens_hsa012120.41821698
87Dopaminergic synapse_Homo sapiens_hsa047280.36501926
88Tyrosine metabolism_Homo sapiens_hsa003500.36083504
89Wnt signaling pathway_Homo sapiens_hsa043100.32745475
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31029626
91Gastric acid secretion_Homo sapiens_hsa049710.29974692
92Asthma_Homo sapiens_hsa053100.29655233
93Hematopoietic cell lineage_Homo sapiens_hsa046400.28109762
94Glucagon signaling pathway_Homo sapiens_hsa049220.27127626
95Mineral absorption_Homo sapiens_hsa049780.26947772
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26482828
97Glycerolipid metabolism_Homo sapiens_hsa005610.25337804
98Arginine and proline metabolism_Homo sapiens_hsa003300.24882084
99Calcium signaling pathway_Homo sapiens_hsa040200.24042575
100mRNA surveillance pathway_Homo sapiens_hsa030150.23748775

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