ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	6.67125775
2	cytidine metabolic process (GO:0046087)	6.67125775
3	cytidine catabolic process (GO:0006216)	6.67125775
4	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.97949110
5	DNA deamination (GO:0045006)	5.88410262
6	sequestering of actin monomers (GO:0042989)	5.51147078
7	T cell migration (GO:0072678)	5.10462966
8	negative regulation by host of viral transcription (GO:0043922)	4.66846674
9	iron-sulfur cluster assembly (GO:0016226)	4.50023498
10	metallo-sulfur cluster assembly (GO:0031163)	4.50023498
11	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.31696320
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.18533002
13	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.74853058
14	forebrain neuron differentiation (GO:0021879)	3.65871708
15	lymphocyte chemotaxis (GO:0048247)	3.61798945
16	chaperone-mediated protein transport (GO:0072321)	3.54782635
17	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.48085961
18	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.48085961
19	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.44600431
20	protein complex biogenesis (GO:0070271)	3.44100810
21	fucose catabolic process (GO:0019317)	3.38292258
22	L-fucose metabolic process (GO:0042354)	3.38292258
23	L-fucose catabolic process (GO:0042355)	3.38292258
24	nonmotile primary cilium assembly (GO:0035058)	3.34350294
25	regulation of lymphocyte chemotaxis (GO:1901623)	3.34273292
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.31642972
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30607413
28	mannosylation (GO:0097502)	3.28312267
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24643817
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24643817
31	NADH dehydrogenase complex assembly (GO:0010257)	3.24643817
32	GPI anchor metabolic process (GO:0006505)	3.20637163
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20546011
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20546011
35	intra-S DNA damage checkpoint (GO:0031573)	3.19414710
36	regulation of T cell receptor signaling pathway (GO:0050856)	3.18201984
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.17106939
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15863416
39	forebrain morphogenesis (GO:0048853)	3.13272627
40	pyrimidine nucleoside catabolic process (GO:0046135)	3.11783670
41	positive regulation of T cell chemotaxis (GO:0010820)	3.11721037
42	regulation of T cell chemotaxis (GO:0010819)	3.11721037
43	eosinophil chemotaxis (GO:0048245)	3.09399502
44	macrophage chemotaxis (GO:0048246)	3.05638050
45	preassembly of GPI anchor in ER membrane (GO:0016254)	3.02945232
46	cell proliferation in forebrain (GO:0021846)	3.02933779
47	spinal cord association neuron differentiation (GO:0021527)	2.99437952
48	retinal rod cell development (GO:0046548)	2.98649272
49	branched-chain amino acid catabolic process (GO:0009083)	2.96341823
50	synapsis (GO:0007129)	2.94574116
51	sympathetic nervous system development (GO:0048485)	2.90568584
52	proteasome assembly (GO:0043248)	2.90108452
53	regulation of protein glycosylation (GO:0060049)	2.89784990
54	DNA demethylation (GO:0080111)	2.89651671
55	protein polyglutamylation (GO:0018095)	2.89433658
56	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.87805994
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.87738056
58	lung secretory cell differentiation (GO:0061140)	2.87714962
59	regulation of B cell receptor signaling pathway (GO:0050855)	2.86846128
60	ribosomal small subunit assembly (GO:0000028)	2.86159436
61	limb bud formation (GO:0060174)	2.84179769
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.83844108
63	termination of RNA polymerase III transcription (GO:0006386)	2.83844108
64	GPI anchor biosynthetic process (GO:0006506)	2.83817154
65	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.83595805
66	negative regulation of viral transcription (GO:0032897)	2.79955097
67	positive regulation of interleukin-8 secretion (GO:2000484)	2.78092478
68	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.77972050
69	eosinophil migration (GO:0072677)	2.77300240
70	regulation of cellular amino acid metabolic process (GO:0006521)	2.77299418
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76607144
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76607144
73	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73698825
74	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73698825
75	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73698825
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.73400014
77	relaxation of smooth muscle (GO:0044557)	2.71843658
78	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.71214140
79	negative regulation of ligase activity (GO:0051352)	2.71214140
80	pyrimidine-containing compound catabolic process (GO:0072529)	2.66047693
81	positive regulation of B cell differentiation (GO:0045579)	2.65803545
82	nucleoside diphosphate catabolic process (GO:0009134)	2.63707810
83	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.63635685
84	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.63635685
85	DNA dealkylation (GO:0035510)	2.63333790
86	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.62158876
87	cornea development in camera-type eye (GO:0061303)	2.62140795
88	positive regulation of monocyte chemotaxis (GO:0090026)	2.61848270
89	cellular response to nicotine (GO:0071316)	2.60425196
90	7-methylguanosine mRNA capping (GO:0006370)	2.58762699
91	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.58053406
92	left/right axis specification (GO:0070986)	2.56755476
93	platelet dense granule organization (GO:0060155)	2.55845717
94	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.55603123
95	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.54267237
96	nerve growth factor signaling pathway (GO:0038180)	2.54177359
97	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.53997152
98	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.53139341
99	RNA capping (GO:0036260)	2.53003888
100	7-methylguanosine RNA capping (GO:0009452)	2.53003888

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	5.04846488
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.90362559
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.52813868
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.39749458
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.10253253
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.90514075
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.82570899
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76346153
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63732262
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61169641
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39994573
12	VDR_22108803_ChIP-Seq_LS180_Human	2.30836582
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.26704963
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.26171077
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.22653953
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.22626677
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.11059319
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08561808
19	EWS_26573619_Chip-Seq_HEK293_Human	1.98508953
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97489948
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93553687
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.91865921
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91375459
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86455996
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.83631389
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82432403
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.80091277
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.78215565
29	EZH2_22144423_ChIP-Seq_EOC_Human	1.67128923
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66783571
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62363898
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.59675941
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59169064
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55930937
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55055233
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.55055233
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.54544574
38	P300_19829295_ChIP-Seq_ESCs_Human	1.54023761
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53081212
40	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.49459776
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.49229623
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.48556828
43	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.48218427
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.47492971
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46200492
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.45606396
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43964674
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.42523654
49	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.40973843
50	FUS_26573619_Chip-Seq_HEK293_Human	1.40545016
51	CIITA_25753668_ChIP-Seq_RAJI_Human	1.39444226
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39126585
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36190330
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34484448
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32995342
56	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32017085
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.31733552
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.28256055
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24836153
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24489410
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23794902
62	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21823949
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17887230
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17887230
65	AR_20517297_ChIP-Seq_VCAP_Human	1.14503927
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.14272603
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12432418
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12432418
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10824402
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.10800077
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10647638
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08751754
73	GATA3_26560356_Chip-Seq_TH2_Human	1.05835270
74	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05413937
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04098726
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02977956
77	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.01570363
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01502895
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.99842490
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99173496
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98501181
82	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97766268
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97544292
84	GBX2_23144817_ChIP-Seq_PC3_Human	0.96895481
85	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96349024
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95796887
87	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.93461796
88	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93308376
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92444111
90	MYB_26560356_Chip-Seq_TH2_Human	0.90843826
91	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.88607464
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88465433
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88403272
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.87499267
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86917227
96	NCOR_22424771_ChIP-Seq_293T_Human	0.86884761
97	TAF15_26573619_Chip-Seq_HEK293_Human	0.86317943
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.86261220
99	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.85897237
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85860089

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.72342613
2	MP0000372_irregular_coat_pigmentation	3.65442702
3	MP0009697_abnormal_copulation	3.31221022
4	MP0008789_abnormal_olfactory_epithelium	3.13950216
5	MP0008995_early_reproductive_senescence	3.12064439
6	MP0002102_abnormal_ear_morphology	2.82674290
7	MP0005671_abnormal_response_to	2.48528001
8	MP0003786_premature_aging	2.42074017
9	MP0006082_CNS_inflammation	2.40544730
10	MP0001529_abnormal_vocalization	2.38148933
11	MP0008877_abnormal_DNA_methylation	2.34986207
12	MP0004133_heterotaxia	2.27914669
13	MP0004147_increased_porphyrin_level	2.24626732
14	MP0005499_abnormal_olfactory_system	2.12153722
15	MP0005394_taste/olfaction_phenotype	2.12153722
16	MP0006276_abnormal_autonomic_nervous	2.06824724
17	MP0003567_abnormal_fetal_cardiomyocyte	2.06255060
18	MP0002138_abnormal_hepatobiliary_system	2.05871933
19	MP0002653_abnormal_ependyma_morphology	1.99252884
20	MP0000631_abnormal_neuroendocrine_gland	1.95951725
21	MP0005646_abnormal_pituitary_gland	1.89519143
22	MP0000049_abnormal_middle_ear	1.81957112
23	MP0003880_abnormal_central_pattern	1.73353471
24	MP0002234_abnormal_pharynx_morphology	1.70024511
25	MP0008058_abnormal_DNA_repair	1.65929692
26	MP0009379_abnormal_foot_pigmentation	1.61809875
27	MP0006072_abnormal_retinal_apoptosis	1.60293281
28	MP0003045_fibrosis	1.58458678
29	MP0005083_abnormal_biliary_tract	1.52078140
30	MP0005377_hearing/vestibular/ear_phenot	1.50262846
31	MP0003878_abnormal_ear_physiology	1.50262846
32	MP0001542_abnormal_bone_strength	1.48859501
33	MP0006054_spinal_hemorrhage	1.47582528
34	MP0005551_abnormal_eye_electrophysiolog	1.44253760
35	MP0003137_abnormal_impulse_conducting	1.32766018
36	MP0009785_altered_susceptibility_to	1.28566530
37	MP0010094_abnormal_chromosome_stability	1.27533927
38	MP0001835_abnormal_antigen_presentation	1.25362374
39	MP0002148_abnormal_hypersensitivity_rea	1.23893634
40	MP0000383_abnormal_hair_follicle	1.21278158
41	MP0001293_anophthalmia	1.18370986
42	MP0000569_abnormal_digit_pigmentation	1.18091575
43	MP0002160_abnormal_reproductive_system	1.15086003
44	MP0008872_abnormal_physiological_respon	1.10606894
45	MP0005253_abnormal_eye_physiology	1.09914671
46	MP0000681_abnormal_thyroid_gland	1.07079787
47	MP0008007_abnormal_cellular_replicative	1.04459606
48	MP0005647_abnormal_sex_gland	1.02129386
49	MP0001764_abnormal_homeostasis	1.01776461
50	MP0004270_analgesia	1.00983065
51	MP0002751_abnormal_autonomic_nervous	1.00351069
52	MP0005670_abnormal_white_adipose	0.99715260
53	MP0003119_abnormal_digestive_system	0.99417327
54	MP0005389_reproductive_system_phenotype	0.97941082
55	MP0001984_abnormal_olfaction	0.97475185
56	MP0004142_abnormal_muscle_tone	0.94718584
57	MP0001119_abnormal_female_reproductive	0.92953617
58	MP0008932_abnormal_embryonic_tissue	0.91137683
59	MP0003787_abnormal_imprinting	0.90232144
60	MP0000613_abnormal_salivary_gland	0.85208118
61	MP0001485_abnormal_pinna_reflex	0.84622736
62	MP0003938_abnormal_ear_development	0.83592128
63	MP0002876_abnormal_thyroid_physiology	0.82519123
64	MP0002723_abnormal_immune_serum	0.81549940
65	MP0005645_abnormal_hypothalamus_physiol	0.80112693
66	MP0002733_abnormal_thermal_nociception	0.77333783
67	MP0003937_abnormal_limbs/digits/tail_de	0.76971772
68	MP0000647_abnormal_sebaceous_gland	0.76666334
69	MP0009765_abnormal_xenobiotic_induced	0.76248807
70	MP0001340_abnormal_eyelid_morphology	0.76245123
71	MP0002233_abnormal_nose_morphology	0.76114132
72	MP0000516_abnormal_urinary_system	0.75551509
73	MP0005367_renal/urinary_system_phenotyp	0.75551509
74	MP0003866_abnormal_defecation	0.73073021
75	MP0000653_abnormal_sex_gland	0.70907959
76	MP0004742_abnormal_vestibular_system	0.70586694
77	MP0001800_abnormal_humoral_immune	0.69468192
78	MP0005195_abnormal_posterior_eye	0.66130578
79	MP0009745_abnormal_behavioral_response	0.65937544
80	MP0005386_behavior/neurological_phenoty	0.65329307
81	MP0004924_abnormal_behavior	0.65329307
82	MP0003755_abnormal_palate_morphology	0.64650558
83	MP0008875_abnormal_xenobiotic_pharmacok	0.63709140
84	MP0008961_abnormal_basal_metabolism	0.62894398
85	MP0002095_abnormal_skin_pigmentation	0.62779734
86	MP0000230_abnormal_systemic_arterial	0.62228147
87	MP0001502_abnormal_circadian_rhythm	0.60747680
88	MP0000343_altered_response_to	0.59861396
89	MP0000026_abnormal_inner_ear	0.59404705
90	MP0003252_abnormal_bile_duct	0.59128632
91	MP0003698_abnormal_male_reproductive	0.58960193
92	MP0002736_abnormal_nociception_after	0.58787814
93	MP0005075_abnormal_melanosome_morpholog	0.58059173
94	MP0009333_abnormal_splenocyte_physiolog	0.57284270
95	MP0001486_abnormal_startle_reflex	0.57067473
96	MP0004883_abnormal_blood_vessel	0.55632844
97	MP0002420_abnormal_adaptive_immunity	0.55360588
98	MP0005379_endocrine/exocrine_gland_phen	0.55354948
99	MP0000689_abnormal_spleen_morphology	0.54968311
100	MP0001145_abnormal_male_reproductive	0.53773915

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abolished electroretinogram (ERG) (HP:0000550)	3.99957729
2	3-Methylglutaconic aciduria (HP:0003535)	3.86444161
3	Stomatitis (HP:0010280)	3.41174757
4	Molar tooth sign on MRI (HP:0002419)	3.24128041
5	Abnormality of midbrain morphology (HP:0002418)	3.24128041
6	Decreased central vision (HP:0007663)	3.17578210
7	Type II lissencephaly (HP:0007260)	3.17009283
8	Medial flaring of the eyebrow (HP:0010747)	3.13526449
9	True hermaphroditism (HP:0010459)	3.06207540
10	Acute necrotizing encephalopathy (HP:0006965)	3.06203211
11	Pancreatic cysts (HP:0001737)	3.04894138
12	Aplastic anemia (HP:0001915)	3.03611268
13	Hypoproteinemia (HP:0003075)	2.94835824
14	Severe combined immunodeficiency (HP:0004430)	2.91348144
15	Thyroid-stimulating hormone excess (HP:0002925)	2.88723266
16	Colon cancer (HP:0003003)	2.88004837
17	Renal Fanconi syndrome (HP:0001994)	2.85844728
18	T lymphocytopenia (HP:0005403)	2.81054879
19	Acute encephalopathy (HP:0006846)	2.79606781
20	Abnormality of DNA repair (HP:0003254)	2.76620234
21	Type I transferrin isoform profile (HP:0003642)	2.72654351
22	Congenital primary aphakia (HP:0007707)	2.71520680
23	Neonatal respiratory distress (HP:0002643)	2.66795883
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.66614069
25	Abnormality of T cell number (HP:0011839)	2.66050599
26	Thyroiditis (HP:0100646)	2.64627865
27	Mitochondrial inheritance (HP:0001427)	2.62101987
28	Gait imbalance (HP:0002141)	2.60042108
29	Nephrogenic diabetes insipidus (HP:0009806)	2.57841422
30	Pendular nystagmus (HP:0012043)	2.57215540
31	Retinal dysplasia (HP:0007973)	2.56357106
32	Delayed CNS myelination (HP:0002188)	2.51426837
33	Abnormality of eosinophils (HP:0001879)	2.50755986
34	Pancreatic fibrosis (HP:0100732)	2.49312661
35	Recurrent corneal erosions (HP:0000495)	2.49131437
36	Aplasia/hypoplasia of the uterus (HP:0008684)	2.49099102
37	Abnormality of B cell number (HP:0010975)	2.48126860
38	Eosinophilia (HP:0001880)	2.47436294
39	Hepatocellular necrosis (HP:0001404)	2.42194565
40	B lymphocytopenia (HP:0010976)	2.41314013
41	Cerebral edema (HP:0002181)	2.37542512
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37211664
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35384761
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35384761
45	Microretrognathia (HP:0000308)	2.34118515
46	Calf muscle hypertrophy (HP:0008981)	2.33316763
47	Sclerocornea (HP:0000647)	2.31717605
48	Progressive macrocephaly (HP:0004481)	2.31261556
49	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.30295603
50	Abnormal protein N-linked glycosylation (HP:0012347)	2.30295603
51	Abnormal protein glycosylation (HP:0012346)	2.30295603
52	Abnormal glycosylation (HP:0012345)	2.30295603
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29160652
54	Severe visual impairment (HP:0001141)	2.27560961
55	Progressive inability to walk (HP:0002505)	2.23479138
56	Combined immunodeficiency (HP:0005387)	2.22855879
57	Type 2 muscle fiber atrophy (HP:0003554)	2.20438347
58	Median cleft lip (HP:0000161)	2.15436690
59	Postaxial foot polydactyly (HP:0001830)	2.14306769
60	Increased CSF lactate (HP:0002490)	2.13769691
61	IgG deficiency (HP:0004315)	2.13674873
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13170410
63	Panhypogammaglobulinemia (HP:0003139)	2.11398423
64	Arthropathy (HP:0003040)	2.09332181
65	Postaxial hand polydactyly (HP:0001162)	2.09037364
66	Emotional lability (HP:0000712)	2.04437339
67	Partial agenesis of the corpus callosum (HP:0001338)	2.03313673
68	Abnormal albumin level (HP:0012116)	2.02487972
69	Hypoalbuminemia (HP:0003073)	2.02487972
70	Bifid tongue (HP:0010297)	2.01459490
71	Increased corneal curvature (HP:0100692)	2.00090070
72	Keratoconus (HP:0000563)	2.00090070
73	Hyperglycinuria (HP:0003108)	1.99441621
74	Muscle hypertrophy of the lower extremities (HP:0008968)	1.98913855
75	Progressive microcephaly (HP:0000253)	1.98664322
76	Autoimmune hemolytic anemia (HP:0001890)	1.95399390
77	Lactic acidosis (HP:0003128)	1.92314022
78	High anterior hairline (HP:0009890)	1.91322610
79	Hepatic necrosis (HP:0002605)	1.89209688
80	Vaginal atresia (HP:0000148)	1.88868931
81	Genital tract atresia (HP:0001827)	1.88831542
82	Episodic fever (HP:0001954)	1.87044554
83	Abnormality of the labia minora (HP:0012880)	1.85225758
84	Cutaneous melanoma (HP:0012056)	1.84847332
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83832815
86	Optic disc pallor (HP:0000543)	1.82014910
87	Nephronophthisis (HP:0000090)	1.81713859
88	Entropion (HP:0000621)	1.81553867
89	Increased intramyocellular lipid droplets (HP:0012240)	1.81015648
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80691581
91	Male pseudohermaphroditism (HP:0000037)	1.79008883
92	Increased serum lactate (HP:0002151)	1.77598777
93	Ureteral stenosis (HP:0000071)	1.74808775
94	Granulocytopenia (HP:0001913)	1.74306800
95	Abnormality of renal resorption (HP:0011038)	1.73573964
96	Abnormality of T cells (HP:0002843)	1.72334841
97	Chorioretinal atrophy (HP:0000533)	1.71045763
98	Erythroderma (HP:0001019)	1.70202038
99	Microvesicular hepatic steatosis (HP:0001414)	1.69656128
100	Increased IgM level (HP:0003496)	1.69505868

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.45282427
2	CDK19	3.39205572
3	MATK	2.96472574
4	PINK1	2.96318345
5	BCKDK	2.29635758
6	NTRK1	2.28087278
7	EPHA3	2.25041959
8	BCR	2.12483720
9	TAOK3	2.12199640
10	KDR	2.05134602
11	EPHA4	1.97335857
12	SRPK1	1.91734625
13	MAP2K7	1.89695649
14	VRK1	1.89500558
15	PBK	1.87540247
16	BMPR1B	1.76003899
17	TNIK	1.63981521
18	NUAK1	1.62626265
19	TRIM28	1.61092599
20	TXK	1.56593285
21	ADRBK2	1.55423124
22	MAP3K4	1.53370934
23	BRSK2	1.52441698
24	GRK1	1.46362223
25	MAP3K6	1.39766958
26	MST4	1.34425922
27	WNK3	1.33463376
28	TEC	1.33178936
29	ERBB3	1.27917030
30	EIF2AK3	1.23760059
31	ZAK	1.23220449
32	MAPK13	1.19907890
33	ITK	1.15181830
34	PRKCQ	1.12585966
35	NME2	1.12373875
36	WNK4	1.07825513
37	SYK	1.06837741
38	VRK2	1.00591904
39	CAMKK2	0.92580226
40	MUSK	0.91133518
41	RPS6KA4	0.89289850
42	MKNK1	0.85104925
43	TLK1	0.82659907
44	PLK2	0.79779284
45	DYRK3	0.78435515
46	PRKCE	0.78012786
47	IKBKB	0.76035196
48	CSF1R	0.75764440
49	MAP3K5	0.73637173
50	CAMK2D	0.72403184
51	CASK	0.71506362
52	EIF2AK2	0.70480758
53	PTK2B	0.70386060
54	BTK	0.69974269
55	ABL2	0.69124551
56	CSNK1A1L	0.67811189
57	DYRK2	0.66883084
58	PIK3CA	0.65537592
59	CSNK1G3	0.64755189
60	MAPKAPK3	0.63728041
61	CAMK1	0.61130446
62	CSNK1G1	0.60581427
63	BRSK1	0.59237653
64	PRKG2	0.58831941
65	NLK	0.55613902
66	STK11	0.54181501
67	FRK	0.53407334
68	MKNK2	0.52668865
69	CAMK2B	0.50718205
70	TNK2	0.49689365
71	CSNK1A1	0.48404389
72	MAP2K4	0.48343757
73	ATR	0.47458520
74	PDK2	0.47372613
75	CSNK2A1	0.47132844
76	AURKB	0.46691979
77	MAP3K7	0.46509297
78	CSNK1G2	0.46182705
79	MAP4K1	0.45727717
80	MAP3K11	0.45225692
81	PLK1	0.44760210
82	PRKCD	0.44184967
83	LIMK1	0.44157210
84	NME1	0.42944771
85	INSRR	0.41530410
86	BMPR2	0.40767468
87	MAPK15	0.40198159
88	RPS6KA5	0.40154955
89	PLK3	0.39661801
90	CAMK2G	0.39345204
91	CSNK2A2	0.39180628
92	IGF1R	0.38978403
93	FGFR1	0.38671474
94	ERBB2	0.37893372
95	LCK	0.37537986
96	PRKACA	0.37373887
97	PRKCA	0.37020162
98	CAMK2A	0.34365240
99	CAMK4	0.34196080
100	PIM1	0.33673793

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.57565415
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.55957167
3	RNA polymerase_Homo sapiens_hsa03020	3.11790883
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90020126
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.70373797
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.68946979
7	Protein export_Homo sapiens_hsa03060	2.60187169
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50632462
9	Parkinsons disease_Homo sapiens_hsa05012	2.32564617
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.12019207
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.06924571
12	Homologous recombination_Homo sapiens_hsa03440	2.03617529
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.90331937
14	Ribosome_Homo sapiens_hsa03010	1.77298392
15	Allograft rejection_Homo sapiens_hsa05330	1.76576312
16	Propanoate metabolism_Homo sapiens_hsa00640	1.72079128
17	RNA degradation_Homo sapiens_hsa03018	1.69568210
18	Huntingtons disease_Homo sapiens_hsa05016	1.65761757
19	Spliceosome_Homo sapiens_hsa03040	1.64399729
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.60060884
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51970424
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51401277
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.44644880
24	Asthma_Homo sapiens_hsa05310	1.40779945
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37816952
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.37322749
27	Alzheimers disease_Homo sapiens_hsa05010	1.33938900
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30350614
29	Phototransduction_Homo sapiens_hsa04744	1.28008719
30	Basal transcription factors_Homo sapiens_hsa03022	1.25209235
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.20656824
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.17935283
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.14643230
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14288557
35	Mismatch repair_Homo sapiens_hsa03430	1.12879905
36	RNA transport_Homo sapiens_hsa03013	1.11646387
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10991332
38	Taste transduction_Homo sapiens_hsa04742	1.10386399
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10350378
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09808108
41	Olfactory transduction_Homo sapiens_hsa04740	1.07012336
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05951042
43	Purine metabolism_Homo sapiens_hsa00230	1.01383740
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.99410405
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98741685
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98603211
47	Butanoate metabolism_Homo sapiens_hsa00650	0.98388703
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.98316504
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.95528804
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92371223
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.90552366
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.88105279
53	Base excision repair_Homo sapiens_hsa03410	0.82351887
54	Peroxisome_Homo sapiens_hsa04146	0.78738061
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.77901675
56	DNA replication_Homo sapiens_hsa03030	0.76922759
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76008714
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76005573
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.75072744
60	Metabolic pathways_Homo sapiens_hsa01100	0.72650268
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72481411
62	Circadian rhythm_Homo sapiens_hsa04710	0.72015383
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.71703552
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.66755176
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64134888
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63502544
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.62925310
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60695325
69	Carbon metabolism_Homo sapiens_hsa01200	0.59804374
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58241187
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57915166
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56802513
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.56320517
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55225986
75	Fatty acid elongation_Homo sapiens_hsa00062	0.54721802
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54585914
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52747460
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51786587
79	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.50597430
80	Alcoholism_Homo sapiens_hsa05034	0.47673472
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45333933
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.45109503
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43959079
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.43164265
85	Salivary secretion_Homo sapiens_hsa04970	0.42681942
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41373738
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40409345
88	Retinol metabolism_Homo sapiens_hsa00830	0.39284732
89	Herpes simplex infection_Homo sapiens_hsa05168	0.37420407
90	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37316615
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37187306
92	Nicotine addiction_Homo sapiens_hsa05033	0.36034465
93	One carbon pool by folate_Homo sapiens_hsa00670	0.34713793
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32343587
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31989221
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31748749
97	Salmonella infection_Homo sapiens_hsa05132	0.31415935
98	Viral myocarditis_Homo sapiens_hsa05416	0.29911343
99	p53 signaling pathway_Homo sapiens_hsa04115	0.29808340
100	Oocyte meiosis_Homo sapiens_hsa04114	0.28550897

EIF4A1P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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