ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.07636929
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.38188057
3	cytidine deamination (GO:0009972)	6.25651775
4	cytidine metabolic process (GO:0046087)	6.25651775
5	cytidine catabolic process (GO:0006216)	6.25651775
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.67642754
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.09484285
8	sequestering of actin monomers (GO:0042989)	4.52079490
9	proteasome assembly (GO:0043248)	4.47452090
10	actin nucleation (GO:0045010)	4.37523825
11	iron-sulfur cluster assembly (GO:0016226)	4.21063027
12	metallo-sulfur cluster assembly (GO:0031163)	4.21063027
13	negative regulation by host of viral transcription (GO:0043922)	4.19942695
14	regulation of cellular amino acid metabolic process (GO:0006521)	4.03632623
15	base-excision repair, AP site formation (GO:0006285)	3.95388136
16	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.78049251
17	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.76956793
18	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.69786593
19	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.69786593
20	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.69786593
21	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.65076948
22	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.65076948
23	protein neddylation (GO:0045116)	3.58348231
24	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.52784467
25	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.52784467
26	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.52543257
27	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.50419925
28	negative regulation of ligase activity (GO:0051352)	3.47007181
29	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.47007181
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.36689545
31	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.30409010
32	positive regulation of interleukin-8 secretion (GO:2000484)	3.30251230
33	negative regulation of T cell apoptotic process (GO:0070233)	3.24900123
34	platelet dense granule organization (GO:0060155)	3.24668744
35	positive thymic T cell selection (GO:0045059)	3.23423369
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.19844686
37	GPI anchor biosynthetic process (GO:0006506)	3.17613259
38	positive regulation of mitochondrial fission (GO:0090141)	3.17450758
39	positive regulation of defense response to virus by host (GO:0002230)	3.15207118
40	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.14521520
41	peptidyl-arginine omega-N-methylation (GO:0035247)	3.14270647
42	rRNA modification (GO:0000154)	3.10386055
43	cellular response to interleukin-15 (GO:0071350)	3.09664837
44	ATP synthesis coupled proton transport (GO:0015986)	3.09205074
45	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.09205074
46	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.07591585
47	GPI anchor metabolic process (GO:0006505)	3.06208393
48	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.04524237
49	positive regulation of calcium-mediated signaling (GO:0050850)	3.00979007
50	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.99723308
51	positive T cell selection (GO:0043368)	2.98539470
52	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.97929302
53	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.95269610
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.95269610
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92826965
56	eosinophil chemotaxis (GO:0048245)	2.92817686
57	ubiquinone biosynthetic process (GO:0006744)	2.92016478
58	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.89873062
59	protein deneddylation (GO:0000338)	2.89631650
60	regulation of cellular amine metabolic process (GO:0033238)	2.89050929
61	positive regulation of cell cycle arrest (GO:0071158)	2.84919288
62	mannosylation (GO:0097502)	2.83256110
63	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.83065968
64	positive regulation of tolerance induction (GO:0002645)	2.82963563
65	pyrimidine nucleoside catabolic process (GO:0046135)	2.80271605
66	positive regulation of ligase activity (GO:0051351)	2.79643409
67	positive regulation of protein homodimerization activity (GO:0090073)	2.79081762
68	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.78866243
69	ubiquinone metabolic process (GO:0006743)	2.77181980
70	negative regulation of viral genome replication (GO:0045071)	2.75228716
71	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.74546813
72	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.74505919
73	water-soluble vitamin biosynthetic process (GO:0042364)	2.74158322
74	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.73803612
75	protein complex biogenesis (GO:0070271)	2.71670103
76	pseudouridine synthesis (GO:0001522)	2.68502840
77	regulation of lymphocyte chemotaxis (GO:1901623)	2.65443324
78	protein-cofactor linkage (GO:0018065)	2.64703463
79	T cell migration (GO:0072678)	2.62907422
80	eosinophil migration (GO:0072677)	2.62729247
81	cullin deneddylation (GO:0010388)	2.60338684
82	regulation of T cell tolerance induction (GO:0002664)	2.59769310
83	DNA double-strand break processing (GO:0000729)	2.58510040
84	regulation of interleukin-8 secretion (GO:2000482)	2.58358786
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.58321345
86	regulation of T cell receptor signaling pathway (GO:0050856)	2.58079843
87	organelle disassembly (GO:1903008)	2.57782544
88	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.57184402
89	negative T cell selection (GO:0043383)	2.56876468
90	peptidyl-arginine N-methylation (GO:0035246)	2.56422650
91	peptidyl-arginine methylation (GO:0018216)	2.56422650
92	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.56402921
93	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.55882849
94	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.54057383
95	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54035485
96	deoxyribonucleotide catabolic process (GO:0009264)	2.53813868
97	DNA catabolic process, exonucleolytic (GO:0000738)	2.53199863
98	histone arginine methylation (GO:0034969)	2.53109204
99	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.52114407
100	DNA demethylation (GO:0080111)	2.51603800

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.92097441
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.70298094
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.64298166
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.56213506
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.30143552
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.42959679
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.37213463
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28051745
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.92381302
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84914564
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72324184
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.56449255
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54058756
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.53015130
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.46275100
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.43956483
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.43168315
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.29297973
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.24295303
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.23814233
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10197033
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92928341
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.89043507
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.83560013
25	VDR_22108803_ChIP-Seq_LS180_Human	1.82499281
26	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.81112678
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.78850656
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.76892193
29	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.73626798
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.72838791
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72336506
32	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.71527384
33	MYB_26560356_Chip-Seq_TH2_Human	1.71061571
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.69434463
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.66332813
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.63232621
37	E2F7_22180533_ChIP-Seq_HELA_Human	1.60533867
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.59109001
39	DCP1A_22483619_ChIP-Seq_HELA_Human	1.54142870
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53979649
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.51164525
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.48698801
43	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.48555610
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.47557973
45	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.46711384
46	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45520091
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.45214662
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.43430696
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.42621730
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.39760475
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38029209
52	GATA3_26560356_Chip-Seq_TH2_Human	1.36964552
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36562262
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36363681
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33578798
56	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33052095
57	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.33041603
58	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.29300734
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.26437932
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.20920299
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.20759750
62	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.18978956
63	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17486185
64	GATA3_27048872_Chip-Seq_THYMUS_Human	1.16702282
65	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.16400988
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14129826
67	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13975394
68	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13927534
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.12855158
70	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.12531668
71	AR_20517297_ChIP-Seq_VCAP_Human	1.12502558
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10445953
73	SPI1_23547873_ChIP-Seq_NB4_Human	1.06314865
74	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05992112
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05873881
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05606282
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04900561
78	TTF2_22483619_ChIP-Seq_HELA_Human	0.99765279
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99275031
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97464849
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97067774
82	NCOR_22424771_ChIP-Seq_293T_Human	0.96283161
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94312980
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94312980
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.92867448
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91657826
87	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91539228
88	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91294468
89	MYB_26560356_Chip-Seq_TH1_Human	0.86501355
90	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.85814816
91	KDM5A_27292631_Chip-Seq_BREAST_Human	0.85685928
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.85269167
93	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.85044783
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84491302
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.83438872
96	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.82439428
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81450343
98	EWS_26573619_Chip-Seq_HEK293_Human	0.80063259
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.78940645
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.78922571

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.77767709
2	MP0009785_altered_susceptibility_to	3.27014988
3	MP0006072_abnormal_retinal_apoptosis	2.92950019
4	MP0001835_abnormal_antigen_presentation	2.89082181
5	MP0003763_abnormal_thymus_physiology	2.77201075
6	MP0004147_increased_porphyrin_level	2.66592657
7	MP0000372_irregular_coat_pigmentation	2.43300990
8	MP0002148_abnormal_hypersensitivity_rea	2.18751157
9	MP0005000_abnormal_immune_tolerance	2.10488324
10	MP0009333_abnormal_splenocyte_physiolog	2.05688360
11	MP0008058_abnormal_DNA_repair	2.05119647
12	MP0006082_CNS_inflammation	2.04024083
13	MP0001800_abnormal_humoral_immune	2.02617097
14	MP0003011_delayed_dark_adaptation	2.01910549
15	MP0003693_abnormal_embryo_hatching	1.99667320
16	MP0005253_abnormal_eye_physiology	1.98954053
17	MP0002723_abnormal_immune_serum	1.98064488
18	MP0001986_abnormal_taste_sensitivity	1.96184020
19	MP0003806_abnormal_nucleotide_metabolis	1.94964004
20	MP0002166_altered_tumor_susceptibility	1.93307915
21	MP0002420_abnormal_adaptive_immunity	1.91874813
22	MP0001819_abnormal_immune_cell	1.87283530
23	MP0005645_abnormal_hypothalamus_physiol	1.85239965
24	MP0003786_premature_aging	1.79719131
25	MP0008875_abnormal_xenobiotic_pharmacok	1.77973263
26	MP0002006_tumorigenesis	1.72422065
27	MP0002102_abnormal_ear_morphology	1.70945681
28	MP0008872_abnormal_physiological_respon	1.70354631
29	MP0005084_abnormal_gallbladder_morpholo	1.69610167
30	MP0005387_immune_system_phenotype	1.67519756
31	MP0001790_abnormal_immune_system	1.67519756
32	MP0005025_abnormal_response_to	1.65608003
33	MP0002452_abnormal_antigen_presenting	1.64320183
34	MP0001529_abnormal_vocalization	1.59868042
35	MP0009764_decreased_sensitivity_to	1.57900939
36	MP0005075_abnormal_melanosome_morpholog	1.54270075
37	MP0001764_abnormal_homeostasis	1.53936931
38	MP0002398_abnormal_bone_marrow	1.45465768
39	MP0010094_abnormal_chromosome_stability	1.44770455
40	MP0000716_abnormal_immune_system	1.44323462
41	MP0010155_abnormal_intestine_physiology	1.42533413
42	MP0000689_abnormal_spleen_morphology	1.41701592
43	MP0001984_abnormal_olfaction	1.40360173
44	MP0002138_abnormal_hepatobiliary_system	1.39831198
45	MP0000685_abnormal_immune_system	1.39055561
46	MP0003866_abnormal_defecation	1.33342779
47	MP0005167_abnormal_blood-brain_barrier	1.33043468
48	MP0008007_abnormal_cellular_replicative	1.30943342
49	MP0006035_abnormal_mitochondrial_morpho	1.28840029
50	MP0002722_abnormal_immune_system	1.28463817
51	MP0001845_abnormal_inflammatory_respons	1.26587020
52	MP0003724_increased_susceptibility_to	1.26582014
53	MP0003195_calcinosis	1.21582612
54	MP0008877_abnormal_DNA_methylation	1.21410825
55	MP0001919_abnormal_reproductive_system	1.21000019
56	MP0001905_abnormal_dopamine_level	1.20877538
57	MP0002429_abnormal_blood_cell	1.18846696
58	MP0004957_abnormal_blastocyst_morpholog	1.17633919
59	MP0008789_abnormal_olfactory_epithelium	1.17494877
60	MP0002876_abnormal_thyroid_physiology	1.17479909
61	MP0000703_abnormal_thymus_morphology	1.17430662
62	MP0002277_abnormal_respiratory_mucosa	1.15589825
63	MP0006054_spinal_hemorrhage	1.12867041
64	MP0003718_maternal_effect	1.11465649
65	MP0009763_increased_sensitivity_to	1.09907175
66	MP0002405_respiratory_system_inflammati	1.09242572
67	MP0005551_abnormal_eye_electrophysiolog	1.09002719
68	MP0002019_abnormal_tumor_incidence	1.07730553
69	MP0005389_reproductive_system_phenotype	1.02804883
70	MP0008469_abnormal_protein_level	1.01985109
71	MP0006036_abnormal_mitochondrial_physio	0.98630330
72	MP0002877_abnormal_melanocyte_morpholog	0.98509927
73	MP0004043_abnormal_pH_regulation	0.97500255
74	MP0001188_hyperpigmentation	0.96245681
75	MP0001968_abnormal_touch/_nociception	0.94853227
76	MP0001873_stomach_inflammation	0.94421190
77	MP0009765_abnormal_xenobiotic_induced	0.94049554
78	MP0008932_abnormal_embryonic_tissue	0.94029770
79	MP0002736_abnormal_nociception_after	0.93402053
80	MP0003186_abnormal_redox_activity	0.93314733
81	MP0005646_abnormal_pituitary_gland	0.91454000
82	MP0002419_abnormal_innate_immunity	0.91041216
83	MP0005410_abnormal_fertilization	0.88451932
84	MP0002837_dystrophic_cardiac_calcinosis	0.87502943
85	MP0008873_increased_physiological_sensi	0.86861334
86	MP0002933_joint_inflammation	0.86680656
87	MP0004145_abnormal_muscle_electrophysio	0.85129253
88	MP0002234_abnormal_pharynx_morphology	0.83587857
89	MP0001542_abnormal_bone_strength	0.83183039
90	MP0004782_abnormal_surfactant_physiolog	0.81148220
91	MP0003221_abnormal_cardiomyocyte_apopto	0.78969081
92	MP0001119_abnormal_female_reproductive	0.77518365
93	MP0006276_abnormal_autonomic_nervous	0.77496653
94	MP0005464_abnormal_platelet_physiology	0.77454360
95	MP0006292_abnormal_olfactory_placode	0.77344277
96	MP0003448_altered_tumor_morphology	0.74025318
97	MP0003567_abnormal_fetal_cardiomyocyte	0.71327182
98	MP0005379_endocrine/exocrine_gland_phen	0.71127121
99	MP0003880_abnormal_central_pattern	0.70209233
100	MP0003252_abnormal_bile_duct	0.66249610

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.45102296
2	T lymphocytopenia (HP:0005403)	4.38116019
3	Severe combined immunodeficiency (HP:0004430)	4.30540048
4	Abnormality of T cell number (HP:0011839)	4.26071900
5	Increased IgM level (HP:0003496)	4.12532850
6	Abnormality of the prostate (HP:0008775)	3.41482894
7	Abnormality of eosinophils (HP:0001879)	3.40401561
8	Combined immunodeficiency (HP:0005387)	3.39067366
9	Mitochondrial inheritance (HP:0001427)	3.38464449
10	Hepatocellular necrosis (HP:0001404)	3.37706838
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.23137146
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.23137146
13	Abnormality of T cells (HP:0002843)	3.19823505
14	Increased intramyocellular lipid droplets (HP:0012240)	3.17438368
15	Abolished electroretinogram (ERG) (HP:0000550)	3.15146927
16	3-Methylglutaconic aciduria (HP:0003535)	3.14299282
17	Thyroiditis (HP:0100646)	3.14292728
18	Hepatic necrosis (HP:0002605)	3.14100927
19	Increased CSF lactate (HP:0002490)	3.09540166
20	Increased hepatocellular lipid droplets (HP:0006565)	3.06924641
21	Congenital stationary night blindness (HP:0007642)	3.06744414
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90806964
23	Acute necrotizing encephalopathy (HP:0006965)	2.90097131
24	Autoimmune hemolytic anemia (HP:0001890)	2.87817243
25	Agammaglobulinemia (HP:0004432)	2.82711877
26	Increased serum lactate (HP:0002151)	2.82095049
27	Hypoproteinemia (HP:0003075)	2.81923523
28	Lipid accumulation in hepatocytes (HP:0006561)	2.81789291
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.78787645
30	Eosinophilia (HP:0001880)	2.75803845
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.67460785
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.67460785
33	Abnormal protein glycosylation (HP:0012346)	2.67460785
34	Abnormal glycosylation (HP:0012345)	2.67460785
35	Type I transferrin isoform profile (HP:0003642)	2.65460346
36	Chronic diarrhea (HP:0002028)	2.65300314
37	Lactic acidosis (HP:0003128)	2.60021244
38	Encephalitis (HP:0002383)	2.59043609
39	Aplastic anemia (HP:0001915)	2.54936184
40	Amyotrophic lateral sclerosis (HP:0007354)	2.54354403
41	Increased muscle lipid content (HP:0009058)	2.53663229
42	Renal cortical cysts (HP:0000803)	2.53454839
43	Renal Fanconi syndrome (HP:0001994)	2.52313707
44	Recurrent cutaneous fungal infections (HP:0011370)	2.50710369
45	Chronic mucocutaneous candidiasis (HP:0002728)	2.50710369
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.48257285
47	Abnormality of alanine metabolism (HP:0010916)	2.48257285
48	Hyperalaninemia (HP:0003348)	2.48257285
49	Attenuation of retinal blood vessels (HP:0007843)	2.43381709
50	Acute encephalopathy (HP:0006846)	2.43335985
51	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.39244964
52	Panhypogammaglobulinemia (HP:0003139)	2.38557652
53	Stomatitis (HP:0010280)	2.32125324
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31511993
55	Dicarboxylic aciduria (HP:0003215)	2.30919932
56	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.30919932
57	Cerebral edema (HP:0002181)	2.29318343
58	Progressive macrocephaly (HP:0004481)	2.29102720
59	Abnormality of T cell physiology (HP:0011840)	2.28307749
60	Pancreatic cysts (HP:0001737)	2.28286502
61	Prostate neoplasm (HP:0100787)	2.25356279
62	Methylmalonic acidemia (HP:0002912)	2.23903977
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21219143
64	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.20986723
65	Granulocytopenia (HP:0001913)	2.18914659
66	Abnormality of B cell number (HP:0010975)	2.17579443
67	Optic disc pallor (HP:0000543)	2.13055678
68	Methylmalonic aciduria (HP:0012120)	2.12813262
69	Decreased central vision (HP:0007663)	2.12654195
70	IgM deficiency (HP:0002850)	2.12217531
71	Pancytopenia (HP:0001876)	2.12162655
72	Emotional lability (HP:0000712)	2.11761562
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04690312
74	Recurrent bronchitis (HP:0002837)	2.01819344
75	Medial flaring of the eyebrow (HP:0010747)	2.01115845
76	Microvesicular hepatic steatosis (HP:0001414)	2.01032076
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00659336
78	Leukocytosis (HP:0001974)	2.00656374
79	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99087311
80	Colon cancer (HP:0003003)	1.97307374
81	Parakeratosis (HP:0001036)	1.96514999
82	CNS demyelination (HP:0007305)	1.95548833
83	Type 2 muscle fiber atrophy (HP:0003554)	1.93417076
84	Hypoplasia of the thymus (HP:0000778)	1.86373564
85	Abnormality of male internal genitalia (HP:0000022)	1.86173890
86	Exercise intolerance (HP:0003546)	1.84584233
87	Autoimmune thrombocytopenia (HP:0001973)	1.83657282
88	Hyperglycinemia (HP:0002154)	1.83186951
89	Generalized aminoaciduria (HP:0002909)	1.82226591
90	Respiratory failure (HP:0002878)	1.80397809
91	Abnormality of midbrain morphology (HP:0002418)	1.79399291
92	Molar tooth sign on MRI (HP:0002419)	1.79399291
93	Muscle fiber atrophy (HP:0100295)	1.78708024
94	Lymphoma (HP:0002665)	1.78264468
95	Constricted visual fields (HP:0001133)	1.75956102
96	Cerebral hypomyelination (HP:0006808)	1.74962698
97	Lethargy (HP:0001254)	1.73730710
98	Abnormality of the anterior horn cell (HP:0006802)	1.72062851
99	Degeneration of anterior horn cells (HP:0002398)	1.72062851
100	Abnormal biliary tract physiology (HP:0012439)	1.71443990

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	6.23747903
2	KDR	3.81093186
3	ZAK	3.70523598
4	VRK2	3.30932206
5	TXK	2.73078185
6	TLK1	2.72940124
7	BCKDK	2.60963008
8	SRPK1	2.46468612
9	LIMK1	2.33785744
10	MAP4K2	2.28979128
11	STK16	2.13986652
12	TESK1	2.11344220
13	GRK1	2.05908538
14	EIF2AK3	2.01042816
15	VRK1	2.00797297
16	BCR	1.95852098
17	ADRBK2	1.88862157
18	TIE1	1.82806951
19	MAP4K1	1.69538455
20	NUAK1	1.58017614
21	TRIM28	1.55867865
22	MAPKAPK3	1.54587902
23	TAOK3	1.50395876
24	CSNK1G3	1.47238786
25	RPS6KA4	1.43073761
26	CSNK1A1L	1.33925710
27	MAP2K7	1.31326326
28	DAPK1	1.30698104
29	BUB1	1.30084559
30	ITK	1.23497931
31	MST4	1.18164844
32	CSF1R	1.17997286
33	CSNK1G1	1.04709274
34	FES	1.04070770
35	CSNK1G2	1.02766076
36	MAP3K12	0.97327583
37	TAF1	0.94635828
38	CDK19	0.94126430
39	TEC	0.92840114
40	GRK6	0.92709452
41	BMPR1B	0.92467372
42	PRKCQ	0.91717924
43	ERBB3	0.91293078
44	PLK4	0.89452097
45	SCYL2	0.88044495
46	SYK	0.87114715
47	MAP3K4	0.79378220
48	KIT	0.78418407
49	RPS6KA5	0.75631122
50	IKBKB	0.74221871
51	MUSK	0.70457051
52	LCK	0.69276685
53	PLK3	0.68182076
54	DYRK2	0.65103855
55	PINK1	0.65003789
56	PLK2	0.63139085
57	NEK1	0.62730806
58	EIF2AK1	0.62643794
59	CDC7	0.61640740
60	ATR	0.61337018
61	WNK3	0.60291609
62	TNK2	0.59430592
63	CCNB1	0.59150058
64	INSRR	0.58959255
65	AURKA	0.55643523
66	LYN	0.54403744
67	MAPK13	0.54085692
68	TBK1	0.52741791
69	MATK	0.52370345
70	PIM2	0.52008054
71	CAMKK2	0.51809251
72	PASK	0.50904503
73	BTK	0.49752777
74	MAPKAPK5	0.47386991
75	IKBKE	0.45984306
76	LMTK2	0.44943419
77	AURKB	0.44117477
78	MAP3K14	0.42556911
79	GRK7	0.42428799
80	CSNK2A1	0.42426055
81	EIF2AK2	0.42058637
82	PDK2	0.41379470
83	TSSK6	0.40947153
84	MKNK1	0.40847949
85	WNK4	0.39822342
86	FRK	0.38465584
87	GRK5	0.37757686
88	PIK3CA	0.35769424
89	MAPK11	0.33438265
90	IGF1R	0.33326283
91	PLK1	0.32948784
92	CDK7	0.31603248
93	CSNK1A1	0.31446196
94	CSK	0.31079023
95	NME1	0.30258477
96	DAPK2	0.24332787
97	PRKCE	0.24276978
98	MAP3K11	0.24233284
99	PRKCA	0.24225671
100	MYLK	0.22681128

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.10804473
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.03517276
3	Graft-versus-host disease_Homo sapiens_hsa05332	2.56450659
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56273956
5	Antigen processing and presentation_Homo sapiens_hsa04612	2.51626099
6	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.39830894
7	Parkinsons disease_Homo sapiens_hsa05012	2.29774582
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20182339
9	RNA polymerase_Homo sapiens_hsa03020	2.17904534
10	Allograft rejection_Homo sapiens_hsa05330	2.16266680
11	Protein export_Homo sapiens_hsa03060	2.14139751
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.09020299
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.81183612
14	DNA replication_Homo sapiens_hsa03030	1.76815361
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64489214
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.63171458
17	Homologous recombination_Homo sapiens_hsa03440	1.61116821
18	Spliceosome_Homo sapiens_hsa03040	1.58267477
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57416321
20	Base excision repair_Homo sapiens_hsa03410	1.53461399
21	Mismatch repair_Homo sapiens_hsa03430	1.53231110
22	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.48449364
23	Asthma_Homo sapiens_hsa05310	1.44022608
24	Phototransduction_Homo sapiens_hsa04744	1.43212244
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.32094904
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26216113
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25079189
28	Shigellosis_Homo sapiens_hsa05131	1.23438871
29	Alzheimers disease_Homo sapiens_hsa05010	1.19983292
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17404146
31	Peroxisome_Homo sapiens_hsa04146	1.16583154
32	Huntingtons disease_Homo sapiens_hsa05016	1.16333099
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.14635651
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.14532935
35	Fatty acid elongation_Homo sapiens_hsa00062	1.14240544
36	Propanoate metabolism_Homo sapiens_hsa00640	1.14222147
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12426708
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11062621
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.10555134
40	RNA degradation_Homo sapiens_hsa03018	1.10350217
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08813008
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.07888532
43	Salmonella infection_Homo sapiens_hsa05132	1.06586978
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.05833752
45	RNA transport_Homo sapiens_hsa03013	1.05643305
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00975078
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99385644
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97829082
49	Basal transcription factors_Homo sapiens_hsa03022	0.97238718
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.94874771
51	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.93791855
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.92775494
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92736397
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91914404
55	Purine metabolism_Homo sapiens_hsa00230	0.90122416
56	Ribosome_Homo sapiens_hsa03010	0.89276438
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88218250
58	Viral myocarditis_Homo sapiens_hsa05416	0.87588632
59	Butanoate metabolism_Homo sapiens_hsa00650	0.85733620
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.84707446
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.83951052
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.83634358
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72664029
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72389117
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72160899
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71458151
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.69863656
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.68939584
69	One carbon pool by folate_Homo sapiens_hsa00670	0.68549173
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66844224
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65709253
72	Herpes simplex infection_Homo sapiens_hsa05168	0.64865035
73	Carbon metabolism_Homo sapiens_hsa01200	0.64057077
74	Caffeine metabolism_Homo sapiens_hsa00232	0.62929498
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59745148
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.59567253
77	Measles_Homo sapiens_hsa05162	0.58994938
78	Metabolic pathways_Homo sapiens_hsa01100	0.57330536
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56758234
80	Sulfur metabolism_Homo sapiens_hsa00920	0.55961925
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49176822
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49032547
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.48914588
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48518992
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47394122
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47260874
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47209776
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46816118
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.46450426
90	Legionellosis_Homo sapiens_hsa05134	0.46442504
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46417130
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.45002372
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.39404023
94	Retinol metabolism_Homo sapiens_hsa00830	0.38324883
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36833643
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36684387
97	Olfactory transduction_Homo sapiens_hsa04740	0.36109011
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32926415
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30416340
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30181117

EIF4A1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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