EIF4A1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.07636929
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.38188057
3cytidine deamination (GO:0009972)6.25651775
4cytidine metabolic process (GO:0046087)6.25651775
5cytidine catabolic process (GO:0006216)6.25651775
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.67642754
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.09484285
8sequestering of actin monomers (GO:0042989)4.52079490
9proteasome assembly (GO:0043248)4.47452090
10actin nucleation (GO:0045010)4.37523825
11iron-sulfur cluster assembly (GO:0016226)4.21063027
12metallo-sulfur cluster assembly (GO:0031163)4.21063027
13negative regulation by host of viral transcription (GO:0043922)4.19942695
14regulation of cellular amino acid metabolic process (GO:0006521)4.03632623
15base-excision repair, AP site formation (GO:0006285)3.95388136
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78049251
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.76956793
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69786593
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69786593
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69786593
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65076948
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65076948
23protein neddylation (GO:0045116)3.58348231
24signal transduction involved in DNA damage checkpoint (GO:0072422)3.52784467
25signal transduction involved in DNA integrity checkpoint (GO:0072401)3.52784467
26signal transduction involved in cell cycle checkpoint (GO:0072395)3.52543257
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50419925
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47007181
29negative regulation of ligase activity (GO:0051352)3.47007181
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.36689545
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30409010
32positive regulation of interleukin-8 secretion (GO:2000484)3.30251230
33negative regulation of T cell apoptotic process (GO:0070233)3.24900123
34platelet dense granule organization (GO:0060155)3.24668744
35positive thymic T cell selection (GO:0045059)3.23423369
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19844686
37GPI anchor biosynthetic process (GO:0006506)3.17613259
38positive regulation of mitochondrial fission (GO:0090141)3.17450758
39positive regulation of defense response to virus by host (GO:0002230)3.15207118
40antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14521520
41peptidyl-arginine omega-N-methylation (GO:0035247)3.14270647
42rRNA modification (GO:0000154)3.10386055
43cellular response to interleukin-15 (GO:0071350)3.09664837
44ATP synthesis coupled proton transport (GO:0015986)3.09205074
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09205074
46positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.07591585
47GPI anchor metabolic process (GO:0006505)3.06208393
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.04524237
49positive regulation of calcium-mediated signaling (GO:0050850)3.00979007
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99723308
51positive T cell selection (GO:0043368)2.98539470
52chaperone mediated protein folding requiring cofactor (GO:0051085)2.97929302
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95269610
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95269610
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92826965
56eosinophil chemotaxis (GO:0048245)2.92817686
57ubiquinone biosynthetic process (GO:0006744)2.92016478
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89873062
59protein deneddylation (GO:0000338)2.89631650
60regulation of cellular amine metabolic process (GO:0033238)2.89050929
61positive regulation of cell cycle arrest (GO:0071158)2.84919288
62mannosylation (GO:0097502)2.83256110
63DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.83065968
64positive regulation of tolerance induction (GO:0002645)2.82963563
65pyrimidine nucleoside catabolic process (GO:0046135)2.80271605
66positive regulation of ligase activity (GO:0051351)2.79643409
67positive regulation of protein homodimerization activity (GO:0090073)2.79081762
68antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.78866243
69ubiquinone metabolic process (GO:0006743)2.77181980
70negative regulation of viral genome replication (GO:0045071)2.75228716
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.74546813
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74505919
73water-soluble vitamin biosynthetic process (GO:0042364)2.74158322
74negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.73803612
75protein complex biogenesis (GO:0070271)2.71670103
76pseudouridine synthesis (GO:0001522)2.68502840
77regulation of lymphocyte chemotaxis (GO:1901623)2.65443324
78protein-cofactor linkage (GO:0018065)2.64703463
79T cell migration (GO:0072678)2.62907422
80eosinophil migration (GO:0072677)2.62729247
81cullin deneddylation (GO:0010388)2.60338684
82regulation of T cell tolerance induction (GO:0002664)2.59769310
83DNA double-strand break processing (GO:0000729)2.58510040
84regulation of interleukin-8 secretion (GO:2000482)2.58358786
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58321345
86regulation of T cell receptor signaling pathway (GO:0050856)2.58079843
87organelle disassembly (GO:1903008)2.57782544
88negative regulation of lymphocyte apoptotic process (GO:0070229)2.57184402
89negative T cell selection (GO:0043383)2.56876468
90peptidyl-arginine N-methylation (GO:0035246)2.56422650
91peptidyl-arginine methylation (GO:0018216)2.56422650
92positive regulation of interleukin-1 beta secretion (GO:0050718)2.56402921
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55882849
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54057383
95establishment of protein localization to mitochondrial membrane (GO:0090151)2.54035485
96deoxyribonucleotide catabolic process (GO:0009264)2.53813868
97DNA catabolic process, exonucleolytic (GO:0000738)2.53199863
98histone arginine methylation (GO:0034969)2.53109204
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52114407
100DNA demethylation (GO:0080111)2.51603800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.92097441
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.70298094
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.64298166
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.56213506
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.30143552
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42959679
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37213463
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.28051745
9VDR_23849224_ChIP-Seq_CD4+_Human2.92381302
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84914564
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.72324184
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56449255
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.54058756
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53015130
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46275100
16FOXP3_21729870_ChIP-Seq_TREG_Human2.43956483
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43168315
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.29297973
19IGF1R_20145208_ChIP-Seq_DFB_Human2.24295303
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23814233
21ZNF274_21170338_ChIP-Seq_K562_Hela2.10197033
22ELK1_19687146_ChIP-ChIP_HELA_Human1.92928341
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89043507
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.83560013
25VDR_22108803_ChIP-Seq_LS180_Human1.82499281
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81112678
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78850656
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76892193
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73626798
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.72838791
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.72336506
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71527384
33MYB_26560356_Chip-Seq_TH2_Human1.71061571
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.69434463
35MYC_18940864_ChIP-ChIP_HL60_Human1.66332813
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63232621
37E2F7_22180533_ChIP-Seq_HELA_Human1.60533867
38GABP_19822575_ChIP-Seq_HepG2_Human1.59109001
39DCP1A_22483619_ChIP-Seq_HELA_Human1.54142870
40CIITA_25753668_ChIP-Seq_RAJI_Human1.53979649
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51164525
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48698801
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48555610
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47557973
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46711384
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45520091
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45214662
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43430696
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42621730
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39760475
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38029209
52GATA3_26560356_Chip-Seq_TH2_Human1.36964552
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36562262
54IRF1_19129219_ChIP-ChIP_H3396_Human1.36363681
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33578798
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.33052095
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33041603
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29300734
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26437932
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20920299
61TP53_22573176_ChIP-Seq_HFKS_Human1.20759750
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18978956
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17486185
64GATA3_27048872_Chip-Seq_THYMUS_Human1.16702282
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16400988
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14129826
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13975394
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13927534
69XRN2_22483619_ChIP-Seq_HELA_Human1.12855158
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12531668
71AR_20517297_ChIP-Seq_VCAP_Human1.12502558
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.10445953
73SPI1_23547873_ChIP-Seq_NB4_Human1.06314865
74HTT_18923047_ChIP-ChIP_STHdh_Human1.05992112
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05873881
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05606282
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04900561
78TTF2_22483619_ChIP-Seq_HELA_Human0.99765279
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99275031
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97464849
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97067774
82NCOR_22424771_ChIP-Seq_293T_Human0.96283161
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94312980
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.94312980
85ERG_20517297_ChIP-Seq_VCAP_Human0.92867448
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91657826
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91539228
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91294468
89MYB_26560356_Chip-Seq_TH1_Human0.86501355
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85814816
91KDM5A_27292631_Chip-Seq_BREAST_Human0.85685928
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.85269167
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85044783
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84491302
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83438872
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82439428
97NANOG_20526341_ChIP-Seq_ESCs_Human0.81450343
98EWS_26573619_Chip-Seq_HEK293_Human0.80063259
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78940645
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78922571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.77767709
2MP0009785_altered_susceptibility_to3.27014988
3MP0006072_abnormal_retinal_apoptosis2.92950019
4MP0001835_abnormal_antigen_presentation2.89082181
5MP0003763_abnormal_thymus_physiology2.77201075
6MP0004147_increased_porphyrin_level2.66592657
7MP0000372_irregular_coat_pigmentation2.43300990
8MP0002148_abnormal_hypersensitivity_rea2.18751157
9MP0005000_abnormal_immune_tolerance2.10488324
10MP0009333_abnormal_splenocyte_physiolog2.05688360
11MP0008058_abnormal_DNA_repair2.05119647
12MP0006082_CNS_inflammation2.04024083
13MP0001800_abnormal_humoral_immune2.02617097
14MP0003011_delayed_dark_adaptation2.01910549
15MP0003693_abnormal_embryo_hatching1.99667320
16MP0005253_abnormal_eye_physiology1.98954053
17MP0002723_abnormal_immune_serum1.98064488
18MP0001986_abnormal_taste_sensitivity1.96184020
19MP0003806_abnormal_nucleotide_metabolis1.94964004
20MP0002166_altered_tumor_susceptibility1.93307915
21MP0002420_abnormal_adaptive_immunity1.91874813
22MP0001819_abnormal_immune_cell1.87283530
23MP0005645_abnormal_hypothalamus_physiol1.85239965
24MP0003786_premature_aging1.79719131
25MP0008875_abnormal_xenobiotic_pharmacok1.77973263
26MP0002006_tumorigenesis1.72422065
27MP0002102_abnormal_ear_morphology1.70945681
28MP0008872_abnormal_physiological_respon1.70354631
29MP0005084_abnormal_gallbladder_morpholo1.69610167
30MP0005387_immune_system_phenotype1.67519756
31MP0001790_abnormal_immune_system1.67519756
32MP0005025_abnormal_response_to1.65608003
33MP0002452_abnormal_antigen_presenting1.64320183
34MP0001529_abnormal_vocalization1.59868042
35MP0009764_decreased_sensitivity_to1.57900939
36MP0005075_abnormal_melanosome_morpholog1.54270075
37MP0001764_abnormal_homeostasis1.53936931
38MP0002398_abnormal_bone_marrow1.45465768
39MP0010094_abnormal_chromosome_stability1.44770455
40MP0000716_abnormal_immune_system1.44323462
41MP0010155_abnormal_intestine_physiology1.42533413
42MP0000689_abnormal_spleen_morphology1.41701592
43MP0001984_abnormal_olfaction1.40360173
44MP0002138_abnormal_hepatobiliary_system1.39831198
45MP0000685_abnormal_immune_system1.39055561
46MP0003866_abnormal_defecation1.33342779
47MP0005167_abnormal_blood-brain_barrier1.33043468
48MP0008007_abnormal_cellular_replicative1.30943342
49MP0006035_abnormal_mitochondrial_morpho1.28840029
50MP0002722_abnormal_immune_system1.28463817
51MP0001845_abnormal_inflammatory_respons1.26587020
52MP0003724_increased_susceptibility_to1.26582014
53MP0003195_calcinosis1.21582612
54MP0008877_abnormal_DNA_methylation1.21410825
55MP0001919_abnormal_reproductive_system1.21000019
56MP0001905_abnormal_dopamine_level1.20877538
57MP0002429_abnormal_blood_cell1.18846696
58MP0004957_abnormal_blastocyst_morpholog1.17633919
59MP0008789_abnormal_olfactory_epithelium1.17494877
60MP0002876_abnormal_thyroid_physiology1.17479909
61MP0000703_abnormal_thymus_morphology1.17430662
62MP0002277_abnormal_respiratory_mucosa1.15589825
63MP0006054_spinal_hemorrhage1.12867041
64MP0003718_maternal_effect1.11465649
65MP0009763_increased_sensitivity_to1.09907175
66MP0002405_respiratory_system_inflammati1.09242572
67MP0005551_abnormal_eye_electrophysiolog1.09002719
68MP0002019_abnormal_tumor_incidence1.07730553
69MP0005389_reproductive_system_phenotype1.02804883
70MP0008469_abnormal_protein_level1.01985109
71MP0006036_abnormal_mitochondrial_physio0.98630330
72MP0002877_abnormal_melanocyte_morpholog0.98509927
73MP0004043_abnormal_pH_regulation0.97500255
74MP0001188_hyperpigmentation0.96245681
75MP0001968_abnormal_touch/_nociception0.94853227
76MP0001873_stomach_inflammation0.94421190
77MP0009765_abnormal_xenobiotic_induced0.94049554
78MP0008932_abnormal_embryonic_tissue0.94029770
79MP0002736_abnormal_nociception_after0.93402053
80MP0003186_abnormal_redox_activity0.93314733
81MP0005646_abnormal_pituitary_gland0.91454000
82MP0002419_abnormal_innate_immunity0.91041216
83MP0005410_abnormal_fertilization0.88451932
84MP0002837_dystrophic_cardiac_calcinosis0.87502943
85MP0008873_increased_physiological_sensi0.86861334
86MP0002933_joint_inflammation0.86680656
87MP0004145_abnormal_muscle_electrophysio0.85129253
88MP0002234_abnormal_pharynx_morphology0.83587857
89MP0001542_abnormal_bone_strength0.83183039
90MP0004782_abnormal_surfactant_physiolog0.81148220
91MP0003221_abnormal_cardiomyocyte_apopto0.78969081
92MP0001119_abnormal_female_reproductive0.77518365
93MP0006276_abnormal_autonomic_nervous0.77496653
94MP0005464_abnormal_platelet_physiology0.77454360
95MP0006292_abnormal_olfactory_placode0.77344277
96MP0003448_altered_tumor_morphology0.74025318
97MP0003567_abnormal_fetal_cardiomyocyte0.71327182
98MP0005379_endocrine/exocrine_gland_phen0.71127121
99MP0003880_abnormal_central_pattern0.70209233
100MP0003252_abnormal_bile_duct0.66249610

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.45102296
2T lymphocytopenia (HP:0005403)4.38116019
3Severe combined immunodeficiency (HP:0004430)4.30540048
4Abnormality of T cell number (HP:0011839)4.26071900
5Increased IgM level (HP:0003496)4.12532850
6Abnormality of the prostate (HP:0008775)3.41482894
7Abnormality of eosinophils (HP:0001879)3.40401561
8Combined immunodeficiency (HP:0005387)3.39067366
9Mitochondrial inheritance (HP:0001427)3.38464449
10Hepatocellular necrosis (HP:0001404)3.37706838
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23137146
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23137146
13Abnormality of T cells (HP:0002843)3.19823505
14Increased intramyocellular lipid droplets (HP:0012240)3.17438368
15Abolished electroretinogram (ERG) (HP:0000550)3.15146927
163-Methylglutaconic aciduria (HP:0003535)3.14299282
17Thyroiditis (HP:0100646)3.14292728
18Hepatic necrosis (HP:0002605)3.14100927
19Increased CSF lactate (HP:0002490)3.09540166
20Increased hepatocellular lipid droplets (HP:0006565)3.06924641
21Congenital stationary night blindness (HP:0007642)3.06744414
22Abnormal mitochondria in muscle tissue (HP:0008316)2.90806964
23Acute necrotizing encephalopathy (HP:0006965)2.90097131
24Autoimmune hemolytic anemia (HP:0001890)2.87817243
25Agammaglobulinemia (HP:0004432)2.82711877
26Increased serum lactate (HP:0002151)2.82095049
27Hypoproteinemia (HP:0003075)2.81923523
28Lipid accumulation in hepatocytes (HP:0006561)2.81789291
29Elevated erythrocyte sedimentation rate (HP:0003565)2.78787645
30Eosinophilia (HP:0001880)2.75803845
31Abnormal protein glycosylation (HP:0012346)2.67460785
32Abnormal glycosylation (HP:0012345)2.67460785
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67460785
34Abnormal protein N-linked glycosylation (HP:0012347)2.67460785
35Type I transferrin isoform profile (HP:0003642)2.65460346
36Chronic diarrhea (HP:0002028)2.65300314
37Lactic acidosis (HP:0003128)2.60021244
38Encephalitis (HP:0002383)2.59043609
39Aplastic anemia (HP:0001915)2.54936184
40Amyotrophic lateral sclerosis (HP:0007354)2.54354403
41Increased muscle lipid content (HP:0009058)2.53663229
42Renal cortical cysts (HP:0000803)2.53454839
43Renal Fanconi syndrome (HP:0001994)2.52313707
44Recurrent cutaneous fungal infections (HP:0011370)2.50710369
45Chronic mucocutaneous candidiasis (HP:0002728)2.50710369
46Abnormality of alanine metabolism (HP:0010916)2.48257285
47Hyperalaninemia (HP:0003348)2.48257285
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48257285
49Attenuation of retinal blood vessels (HP:0007843)2.43381709
50Acute encephalopathy (HP:0006846)2.43335985
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.39244964
52Panhypogammaglobulinemia (HP:0003139)2.38557652
53Stomatitis (HP:0010280)2.32125324
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31511993
55Dicarboxylic aciduria (HP:0003215)2.30919932
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30919932
57Cerebral edema (HP:0002181)2.29318343
58Progressive macrocephaly (HP:0004481)2.29102720
59Abnormality of T cell physiology (HP:0011840)2.28307749
60Pancreatic cysts (HP:0001737)2.28286502
61Prostate neoplasm (HP:0100787)2.25356279
62Methylmalonic acidemia (HP:0002912)2.23903977
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21219143
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.20986723
65Granulocytopenia (HP:0001913)2.18914659
66Abnormality of B cell number (HP:0010975)2.17579443
67Optic disc pallor (HP:0000543)2.13055678
68Methylmalonic aciduria (HP:0012120)2.12813262
69Decreased central vision (HP:0007663)2.12654195
70IgM deficiency (HP:0002850)2.12217531
71Pancytopenia (HP:0001876)2.12162655
72Emotional lability (HP:0000712)2.11761562
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04690312
74Recurrent bronchitis (HP:0002837)2.01819344
75Medial flaring of the eyebrow (HP:0010747)2.01115845
76Microvesicular hepatic steatosis (HP:0001414)2.01032076
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00659336
78Leukocytosis (HP:0001974)2.00656374
79Aplasia/hypoplasia of the uterus (HP:0008684)1.99087311
80Colon cancer (HP:0003003)1.97307374
81Parakeratosis (HP:0001036)1.96514999
82CNS demyelination (HP:0007305)1.95548833
83Type 2 muscle fiber atrophy (HP:0003554)1.93417076
84Hypoplasia of the thymus (HP:0000778)1.86373564
85Abnormality of male internal genitalia (HP:0000022)1.86173890
86Exercise intolerance (HP:0003546)1.84584233
87Autoimmune thrombocytopenia (HP:0001973)1.83657282
88Hyperglycinemia (HP:0002154)1.83186951
89Generalized aminoaciduria (HP:0002909)1.82226591
90Respiratory failure (HP:0002878)1.80397809
91Abnormality of midbrain morphology (HP:0002418)1.79399291
92Molar tooth sign on MRI (HP:0002419)1.79399291
93Muscle fiber atrophy (HP:0100295)1.78708024
94Lymphoma (HP:0002665)1.78264468
95Constricted visual fields (HP:0001133)1.75956102
96Cerebral hypomyelination (HP:0006808)1.74962698
97Lethargy (HP:0001254)1.73730710
98Abnormality of the anterior horn cell (HP:0006802)1.72062851
99Degeneration of anterior horn cells (HP:0002398)1.72062851
100Abnormal biliary tract physiology (HP:0012439)1.71443990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.23747903
2KDR3.81093186
3ZAK3.70523598
4VRK23.30932206
5TXK2.73078185
6TLK12.72940124
7BCKDK2.60963008
8SRPK12.46468612
9LIMK12.33785744
10MAP4K22.28979128
11STK162.13986652
12TESK12.11344220
13GRK12.05908538
14EIF2AK32.01042816
15VRK12.00797297
16BCR1.95852098
17ADRBK21.88862157
18TIE11.82806951
19MAP4K11.69538455
20NUAK11.58017614
21TRIM281.55867865
22MAPKAPK31.54587902
23TAOK31.50395876
24CSNK1G31.47238786
25RPS6KA41.43073761
26CSNK1A1L1.33925710
27MAP2K71.31326326
28DAPK11.30698104
29BUB11.30084559
30ITK1.23497931
31MST41.18164844
32CSF1R1.17997286
33CSNK1G11.04709274
34FES1.04070770
35CSNK1G21.02766076
36MAP3K120.97327583
37TAF10.94635828
38CDK190.94126430
39TEC0.92840114
40GRK60.92709452
41BMPR1B0.92467372
42PRKCQ0.91717924
43ERBB30.91293078
44PLK40.89452097
45SCYL20.88044495
46SYK0.87114715
47MAP3K40.79378220
48KIT0.78418407
49RPS6KA50.75631122
50IKBKB0.74221871
51MUSK0.70457051
52LCK0.69276685
53PLK30.68182076
54DYRK20.65103855
55PINK10.65003789
56PLK20.63139085
57NEK10.62730806
58EIF2AK10.62643794
59CDC70.61640740
60ATR0.61337018
61WNK30.60291609
62TNK20.59430592
63CCNB10.59150058
64INSRR0.58959255
65AURKA0.55643523
66LYN0.54403744
67MAPK130.54085692
68TBK10.52741791
69MATK0.52370345
70PIM20.52008054
71CAMKK20.51809251
72PASK0.50904503
73BTK0.49752777
74MAPKAPK50.47386991
75IKBKE0.45984306
76LMTK20.44943419
77AURKB0.44117477
78MAP3K140.42556911
79GRK70.42428799
80CSNK2A10.42426055
81EIF2AK20.42058637
82PDK20.41379470
83TSSK60.40947153
84MKNK10.40847949
85WNK40.39822342
86FRK0.38465584
87GRK50.37757686
88PIK3CA0.35769424
89MAPK110.33438265
90IGF1R0.33326283
91PLK10.32948784
92CDK70.31603248
93CSNK1A10.31446196
94CSK0.31079023
95NME10.30258477
96DAPK20.24332787
97PRKCE0.24276978
98MAP3K110.24233284
99PRKCA0.24225671
100MYLK0.22681128

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.10804473
2Primary immunodeficiency_Homo sapiens_hsa053404.03517276
3Graft-versus-host disease_Homo sapiens_hsa053322.56450659
4Oxidative phosphorylation_Homo sapiens_hsa001902.56273956
5Antigen processing and presentation_Homo sapiens_hsa046122.51626099
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39830894
7Parkinsons disease_Homo sapiens_hsa050122.29774582
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20182339
9RNA polymerase_Homo sapiens_hsa030202.17904534
10Allograft rejection_Homo sapiens_hsa053302.16266680
11Protein export_Homo sapiens_hsa030602.14139751
12Autoimmune thyroid disease_Homo sapiens_hsa053202.09020299
13Type I diabetes mellitus_Homo sapiens_hsa049401.81183612
14DNA replication_Homo sapiens_hsa030301.76815361
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64489214
16Rheumatoid arthritis_Homo sapiens_hsa053231.63171458
17Homologous recombination_Homo sapiens_hsa034401.61116821
18Spliceosome_Homo sapiens_hsa030401.58267477
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.57416321
20Base excision repair_Homo sapiens_hsa034101.53461399
21Mismatch repair_Homo sapiens_hsa034301.53231110
22Hematopoietic cell lineage_Homo sapiens_hsa046401.48449364
23Asthma_Homo sapiens_hsa053101.44022608
24Phototransduction_Homo sapiens_hsa047441.43212244
25Nucleotide excision repair_Homo sapiens_hsa034201.32094904
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26216113
27Pyrimidine metabolism_Homo sapiens_hsa002401.25079189
28Shigellosis_Homo sapiens_hsa051311.23438871
29Alzheimers disease_Homo sapiens_hsa050101.19983292
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17404146
31Peroxisome_Homo sapiens_hsa041461.16583154
32Huntingtons disease_Homo sapiens_hsa050161.16333099
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14635651
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14532935
35Fatty acid elongation_Homo sapiens_hsa000621.14240544
36Propanoate metabolism_Homo sapiens_hsa006401.14222147
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12426708
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11062621
39Nitrogen metabolism_Homo sapiens_hsa009101.10555134
40RNA degradation_Homo sapiens_hsa030181.10350217
41Fanconi anemia pathway_Homo sapiens_hsa034601.08813008
42Non-homologous end-joining_Homo sapiens_hsa034501.07888532
43Salmonella infection_Homo sapiens_hsa051321.06586978
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05833752
45RNA transport_Homo sapiens_hsa030131.05643305
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00975078
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99385644
48Linoleic acid metabolism_Homo sapiens_hsa005910.97829082
49Basal transcription factors_Homo sapiens_hsa030220.97238718
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94874771
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93791855
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.92775494
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92736397
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91914404
55Purine metabolism_Homo sapiens_hsa002300.90122416
56Ribosome_Homo sapiens_hsa030100.89276438
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88218250
58Viral myocarditis_Homo sapiens_hsa054160.87588632
59Butanoate metabolism_Homo sapiens_hsa006500.85733620
60T cell receptor signaling pathway_Homo sapiens_hsa046600.84707446
61Steroid biosynthesis_Homo sapiens_hsa001000.83951052
62Selenocompound metabolism_Homo sapiens_hsa004500.83634358
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72664029
64Systemic lupus erythematosus_Homo sapiens_hsa053220.72389117
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72160899
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.71458151
67Biosynthesis of amino acids_Homo sapiens_hsa012300.69863656
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68939584
69One carbon pool by folate_Homo sapiens_hsa006700.68549173
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66844224
71Collecting duct acid secretion_Homo sapiens_hsa049660.65709253
72Herpes simplex infection_Homo sapiens_hsa051680.64865035
73Carbon metabolism_Homo sapiens_hsa012000.64057077
74Caffeine metabolism_Homo sapiens_hsa002320.62929498
75Cardiac muscle contraction_Homo sapiens_hsa042600.59745148
76Epstein-Barr virus infection_Homo sapiens_hsa051690.59567253
77Measles_Homo sapiens_hsa051620.58994938
78Metabolic pathways_Homo sapiens_hsa011000.57330536
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56758234
80Sulfur metabolism_Homo sapiens_hsa009200.55961925
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.49176822
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49032547
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48914588
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48518992
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.47394122
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47260874
87Arachidonic acid metabolism_Homo sapiens_hsa005900.47209776
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46816118
89Tryptophan metabolism_Homo sapiens_hsa003800.46450426
90Legionellosis_Homo sapiens_hsa051340.46442504
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46417130
92Fatty acid metabolism_Homo sapiens_hsa012120.45002372
93Ether lipid metabolism_Homo sapiens_hsa005650.39404023
94Retinol metabolism_Homo sapiens_hsa008300.38324883
95Chemical carcinogenesis_Homo sapiens_hsa052040.36833643
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36684387
97Olfactory transduction_Homo sapiens_hsa047400.36109011
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.32926415
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30416340
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30181117

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