ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.80236006
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.61362522
3	cytidine catabolic process (GO:0006216)	5.42713281
4	cytidine deamination (GO:0009972)	5.42713281
5	cytidine metabolic process (GO:0046087)	5.42713281
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.78059619
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.14255305
8	metallo-sulfur cluster assembly (GO:0031163)	3.73411862
9	iron-sulfur cluster assembly (GO:0016226)	3.73411862
10	actin nucleation (GO:0045010)	3.70663446
11	regulation of cellular amino acid metabolic process (GO:0006521)	3.49959092
12	proteasome assembly (GO:0043248)	3.49353589
13	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.43640405
14	sequestering of actin monomers (GO:0042989)	3.37543661
15	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.35045734
16	ubiquinone biosynthetic process (GO:0006744)	3.29888499
17	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.26472266
18	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.26472266
19	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.26472266
20	negative regulation of T cell apoptotic process (GO:0070233)	3.23836437
21	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.23204732
22	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.23204732
23	protein neddylation (GO:0045116)	3.19146232
24	protein deneddylation (GO:0000338)	3.17764469
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.17616185
26	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.17616185
27	positive regulation of defense response to virus by host (GO:0002230)	3.17459697
28	mannosylation (GO:0097502)	3.17198460
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.16349544
30	positive regulation of interleukin-8 secretion (GO:2000484)	3.16061384
31	positive regulation of prostaglandin secretion (GO:0032308)	3.11887032
32	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.11267848
33	negative regulation of ligase activity (GO:0051352)	3.11267848
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10154592
35	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.09262304
36	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.09262304
37	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.08358754
38	ubiquinone metabolic process (GO:0006743)	3.08211717
39	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.06449552
40	GPI anchor biosynthetic process (GO:0006506)	3.06363212
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.03224296
42	ATP synthesis coupled proton transport (GO:0015986)	3.03224296
43	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.00748749
44	cellular response to interleukin-15 (GO:0071350)	3.00186975
45	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.99854590
46	base-excision repair, AP site formation (GO:0006285)	2.99435029
47	positive regulation of T cell cytokine production (GO:0002726)	2.99008122
48	GPI anchor metabolic process (GO:0006505)	2.99001855
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98114804
50	response to interferon-beta (GO:0035456)	2.97877738
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.94674145
52	protein-cofactor linkage (GO:0018065)	2.92601193
53	cullin deneddylation (GO:0010388)	2.92245861
54	adenosine metabolic process (GO:0046085)	2.92159816
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.90806897
56	termination of RNA polymerase III transcription (GO:0006386)	2.87475747
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.87475747
58	negative regulation by host of viral transcription (GO:0043922)	2.86269629
59	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.82475010
60	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.82291315
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76730391
62	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.75643144
63	regulation of interleukin-8 secretion (GO:2000482)	2.75607346
64	rRNA modification (GO:0000154)	2.73908781
65	positive thymic T cell selection (GO:0045059)	2.71872315
66	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.71468548
67	protein complex biogenesis (GO:0070271)	2.71160848
68	L-methionine salvage (GO:0071267)	2.70977999
69	L-methionine biosynthetic process (GO:0071265)	2.70977999
70	amino acid salvage (GO:0043102)	2.70977999
71	negative T cell selection (GO:0043383)	2.70911665
72	branched-chain amino acid catabolic process (GO:0009083)	2.69393685
73	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.66900159
74	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.66017658
75	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65197006
76	regulation of chronic inflammatory response (GO:0002676)	2.65140940
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.65105174
78	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.64914673
79	positive regulation of T cell mediated immunity (GO:0002711)	2.62877886
80	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.62495226
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.62255146
82	quinone biosynthetic process (GO:1901663)	2.58324257
83	DNA demethylation (GO:0080111)	2.57548207
84	S-adenosylmethionine metabolic process (GO:0046500)	2.56647190
85	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.56315762
86	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.54957109
87	regulation of regulatory T cell differentiation (GO:0045589)	2.54631203
88	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.53862460
89	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53003232
90	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.52985246
91	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.52557693
92	NADH dehydrogenase complex assembly (GO:0010257)	2.52557693
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.52557693
94	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.51917245
95	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.51773912
96	positive regulation of ligase activity (GO:0051351)	2.51311186
97	regulation of T cell mediated cytotoxicity (GO:0001914)	2.50160319
98	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.49253908
99	regulation of defense response to virus by host (GO:0050691)	2.48660642
100	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.48407495

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.36913889
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.23748523
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.17772372
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.97850668
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.66645127
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.36062829
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.30185402
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.99328366
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.98425590
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.93016724
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.77292692
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70526143
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60028052
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.44403471
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.39915728
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35225831
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.35178361
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34283389
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.27936158
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26939636
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.24551398
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.22236866
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07160533
24	VDR_22108803_ChIP-Seq_LS180_Human	1.91868184
25	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.90827627
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87092230
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.80563279
28	CIITA_25753668_ChIP-Seq_RAJI_Human	1.79042869
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.77609286
30	MYB_26560356_Chip-Seq_TH2_Human	1.75136184
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70752165
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69948268
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.69641375
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.68853520
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68841273
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63989706
37	GATA3_26560356_Chip-Seq_TH2_Human	1.59490746
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59271264
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57623914
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.56433819
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55103467
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.54803492
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.52256868
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51486710
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.47569963
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47312895
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.47296127
48	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43335845
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43328914
50	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.41331844
51	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37968490
52	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.34783644
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33866826
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.30433743
55	GATA3_27048872_Chip-Seq_THYMUS_Human	1.29215620
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26444903
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25777064
58	AR_20517297_ChIP-Seq_VCAP_Human	1.24766351
59	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.24511898
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22819706
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22705936
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.22147539
63	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20801143
64	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.20226218
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17961710
66	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16248233
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13351856
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13351856
69	SPI1_23547873_ChIP-Seq_NB4_Human	1.12893705
70	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.12886883
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12602939
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12220700
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12037230
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10449135
75	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.09739924
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.09568732
77	TTF2_22483619_ChIP-Seq_HELA_Human	1.06755419
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06145523
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04471406
80	EWS_26573619_Chip-Seq_HEK293_Human	1.03432118
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03113276
82	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.01922477
83	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98516608
84	XRN2_22483619_ChIP-Seq_HELA_Human	0.98380988
85	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98067870
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96395696
87	MYB_26560356_Chip-Seq_TH1_Human	0.95271516
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.95016252
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94095292
90	NCOR_22424771_ChIP-Seq_293T_Human	0.92936582
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91528417
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.90816072
93	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.90735449
94	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90451258
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.88765151
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87367347
97	FUS_26573619_Chip-Seq_HEK293_Human	0.86419613
98	GATA3_26560356_Chip-Seq_TH1_Human	0.85973661
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.85528503
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84739859

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.60780711
2	MP0001835_abnormal_antigen_presentation	3.31286580
3	MP0009785_altered_susceptibility_to	2.77239150
4	MP0006072_abnormal_retinal_apoptosis	2.75618144
5	MP0002148_abnormal_hypersensitivity_rea	2.52654489
6	MP0002102_abnormal_ear_morphology	2.35086422
7	MP0005000_abnormal_immune_tolerance	2.34161260
8	MP0003724_increased_susceptibility_to	2.33713126
9	MP0000685_abnormal_immune_system	2.27004302
10	MP0004147_increased_porphyrin_level	2.23648436
11	MP0001800_abnormal_humoral_immune	2.19746637
12	MP0003763_abnormal_thymus_physiology	2.19078213
13	MP0000372_irregular_coat_pigmentation	2.10864941
14	MP0002723_abnormal_immune_serum	2.09624788
15	MP0003786_premature_aging	1.99452388
16	MP0005075_abnormal_melanosome_morpholog	1.95443609
17	MP0002420_abnormal_adaptive_immunity	1.94010321
18	MP0001819_abnormal_immune_cell	1.92023572
19	MP0005084_abnormal_gallbladder_morpholo	1.90927093
20	MP0005646_abnormal_pituitary_gland	1.84090147
21	MP0002166_altered_tumor_susceptibility	1.83074943
22	MP0008058_abnormal_DNA_repair	1.82625470
23	MP0002452_abnormal_antigen_presenting	1.81145965
24	MP0009333_abnormal_splenocyte_physiolog	1.75444945
25	MP0005253_abnormal_eye_physiology	1.74666089
26	MP0003806_abnormal_nucleotide_metabolis	1.74333761
27	MP0009764_decreased_sensitivity_to	1.68210613
28	MP0002736_abnormal_nociception_after	1.67099745
29	MP0001790_abnormal_immune_system	1.66516167
30	MP0005387_immune_system_phenotype	1.66516167
31	MP0003436_decreased_susceptibility_to	1.65846004
32	MP0005025_abnormal_response_to	1.59634967
33	MP0002006_tumorigenesis	1.59224874
34	MP0008875_abnormal_xenobiotic_pharmacok	1.54764722
35	MP0002398_abnormal_bone_marrow	1.51498668
36	MP0000716_abnormal_immune_system	1.49692561
37	MP0005645_abnormal_hypothalamus_physiol	1.48509185
38	MP0000689_abnormal_spleen_morphology	1.47643483
39	MP0008872_abnormal_physiological_respon	1.47299001
40	MP0001968_abnormal_touch/_nociception	1.45863018
41	MP0008877_abnormal_DNA_methylation	1.35213619
42	MP0002722_abnormal_immune_system	1.33503094
43	MP0001986_abnormal_taste_sensitivity	1.32324527
44	MP0006082_CNS_inflammation	1.32057187
45	MP0010094_abnormal_chromosome_stability	1.30477681
46	MP0002138_abnormal_hepatobiliary_system	1.28522582
47	MP0003011_delayed_dark_adaptation	1.28370101
48	MP0001845_abnormal_inflammatory_respons	1.28298847
49	MP0001764_abnormal_homeostasis	1.25618814
50	MP0008995_early_reproductive_senescence	1.24639355
51	MP0010155_abnormal_intestine_physiology	1.23535535
52	MP0006035_abnormal_mitochondrial_morpho	1.22588883
53	MP0001905_abnormal_dopamine_level	1.21918593
54	MP0002429_abnormal_blood_cell	1.21814930
55	MP0002419_abnormal_innate_immunity	1.21531426
56	MP0002876_abnormal_thyroid_physiology	1.20111278
57	MP0002405_respiratory_system_inflammati	1.20070648
58	MP0000703_abnormal_thymus_morphology	1.18864969
59	MP0003866_abnormal_defecation	1.16674272
60	MP0008007_abnormal_cellular_replicative	1.14997997
61	MP0006276_abnormal_autonomic_nervous	1.14030817
62	MP0003195_calcinosis	1.12222526
63	MP0005551_abnormal_eye_electrophysiolog	1.11961600
64	MP0009697_abnormal_copulation	1.11898781
65	MP0005410_abnormal_fertilization	1.11425075
66	MP0006036_abnormal_mitochondrial_physio	1.10345922
67	MP0001873_stomach_inflammation	1.10244078
68	MP0001501_abnormal_sleep_pattern	1.08459274
69	MP0003880_abnormal_central_pattern	1.08175465
70	MP0001919_abnormal_reproductive_system	1.05237831
71	MP0002234_abnormal_pharynx_morphology	1.04598222
72	MP0003693_abnormal_embryo_hatching	1.02518586
73	MP0001529_abnormal_vocalization	1.00066516
74	MP0001984_abnormal_olfaction	0.99928839
75	MP0008469_abnormal_protein_level	0.99510167
76	MP0009763_increased_sensitivity_to	0.99286043
77	MP0002933_joint_inflammation	0.99109964
78	MP0006292_abnormal_olfactory_placode	0.97487705
79	MP0002019_abnormal_tumor_incidence	0.97378466
80	MP0005389_reproductive_system_phenotype	0.91825312
81	MP0000465_gastrointestinal_hemorrhage	0.90657113
82	MP0001853_heart_inflammation	0.90089331
83	MP0003718_maternal_effect	0.88193856
84	MP0004145_abnormal_muscle_electrophysio	0.87559532
85	MP0005464_abnormal_platelet_physiology	0.85777385
86	MP0008789_abnormal_olfactory_epithelium	0.84168364
87	MP0004947_skin_inflammation	0.81273476
88	MP0002751_abnormal_autonomic_nervous	0.80592908
89	MP0009765_abnormal_xenobiotic_induced	0.79760018
90	MP0004142_abnormal_muscle_tone	0.78168399
91	MP0003646_muscle_fatigue	0.75924992
92	MP0001533_abnormal_skeleton_physiology	0.73957518
93	MP0003137_abnormal_impulse_conducting	0.70160507
94	MP0003252_abnormal_bile_duct	0.69755262
95	MP0008873_increased_physiological_sensi	0.69253027
96	MP0004782_abnormal_surfactant_physiolog	0.68841886
97	MP0002277_abnormal_respiratory_mucosa	0.68703324
98	MP0005636_abnormal_mineral_homeostasis	0.68116198
99	MP0005167_abnormal_blood-brain_barrier	0.67391514
100	MP0001119_abnormal_female_reproductive	0.65767130

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.51229900
2	Severe combined immunodeficiency (HP:0004430)	3.60329289
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.60082931
4	Mitochondrial inheritance (HP:0001427)	3.47470069
5	Hepatocellular necrosis (HP:0001404)	3.41109272
6	Acute necrotizing encephalopathy (HP:0006965)	3.33857068
7	Abnormality of the prostate (HP:0008775)	3.31120923
8	3-Methylglutaconic aciduria (HP:0003535)	3.29270322
9	T lymphocytopenia (HP:0005403)	3.28008509
10	Increased CSF lactate (HP:0002490)	3.25924502
11	Abnormality of T cell number (HP:0011839)	3.23633436
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11382778
13	Hepatic necrosis (HP:0002605)	3.11320712
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.00165465
15	Abolished electroretinogram (ERG) (HP:0000550)	2.95846150
16	Pancreatic cysts (HP:0001737)	2.91204309
17	Acute encephalopathy (HP:0006846)	2.89673073
18	Increased hepatocellular lipid droplets (HP:0006565)	2.85470036
19	Abnormality of eosinophils (HP:0001879)	2.82422402
20	Hypoproteinemia (HP:0003075)	2.81890184
21	Combined immunodeficiency (HP:0005387)	2.81331046
22	IgM deficiency (HP:0002850)	2.81329404
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.80133228
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.80133228
25	Progressive macrocephaly (HP:0004481)	2.80096201
26	Type I transferrin isoform profile (HP:0003642)	2.79834679
27	Increased serum lactate (HP:0002151)	2.79281375
28	Abnormality of T cells (HP:0002843)	2.79079853
29	Increased IgM level (HP:0003496)	2.69700454
30	Methylmalonic acidemia (HP:0002912)	2.67474509
31	Lactic acidosis (HP:0003128)	2.67181393
32	Increased intramyocellular lipid droplets (HP:0012240)	2.62733962
33	Lipid accumulation in hepatocytes (HP:0006561)	2.56981481
34	Thyroiditis (HP:0100646)	2.56777597
35	Attenuation of retinal blood vessels (HP:0007843)	2.56558789
36	Abnormal protein glycosylation (HP:0012346)	2.55970098
37	Abnormal glycosylation (HP:0012345)	2.55970098
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.55970098
39	Abnormal protein N-linked glycosylation (HP:0012347)	2.55970098
40	Cerebral edema (HP:0002181)	2.54878603
41	Aplastic anemia (HP:0001915)	2.52214453
42	Eosinophilia (HP:0001880)	2.49941607
43	Stomatitis (HP:0010280)	2.48704471
44	Abnormality of alanine metabolism (HP:0010916)	2.46566262
45	Hyperalaninemia (HP:0003348)	2.46566262
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46566262
47	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45199640
48	Renal cortical cysts (HP:0000803)	2.42831939
49	Methylmalonic aciduria (HP:0012120)	2.38407388
50	Panhypogammaglobulinemia (HP:0003139)	2.33026594
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.32487458
52	Abnormality of B cell number (HP:0010975)	2.29781679
53	True hermaphroditism (HP:0010459)	2.29288970
54	Autoimmune hemolytic anemia (HP:0001890)	2.29121322
55	Congenital stationary night blindness (HP:0007642)	2.28710097
56	Pancytopenia (HP:0001876)	2.28540121
57	Abnormality of T cell physiology (HP:0011840)	2.27751028
58	Agammaglobulinemia (HP:0004432)	2.27129825
59	Abnormality of midbrain morphology (HP:0002418)	2.26687764
60	Molar tooth sign on MRI (HP:0002419)	2.26687764
61	Renal Fanconi syndrome (HP:0001994)	2.24349591
62	Optic disc pallor (HP:0000543)	2.21106462
63	Encephalitis (HP:0002383)	2.20363069
64	Decreased central vision (HP:0007663)	2.16521017
65	Dicarboxylic aciduria (HP:0003215)	2.14939968
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.14939968
67	Pancreatic fibrosis (HP:0100732)	2.14863737
68	Chronic diarrhea (HP:0002028)	2.12990906
69	Type 2 muscle fiber atrophy (HP:0003554)	2.08154578
70	Amyotrophic lateral sclerosis (HP:0007354)	2.07772481
71	Increased muscle lipid content (HP:0009058)	2.06467203
72	Hypothermia (HP:0002045)	2.02885442
73	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01077866
74	Granulocytopenia (HP:0001913)	2.00455467
75	Type II lissencephaly (HP:0007260)	1.98049956
76	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.97590953
77	Hypoplasia of the uterus (HP:0000013)	1.95940609
78	B lymphocytopenia (HP:0010976)	1.95618693
79	Abnormality of the renal cortex (HP:0011035)	1.95233978
80	Stomach cancer (HP:0012126)	1.94334647
81	Progressive microcephaly (HP:0000253)	1.93071729
82	Delayed CNS myelination (HP:0002188)	1.92201934
83	Lethargy (HP:0001254)	1.90508597
84	Leukocytosis (HP:0001974)	1.89564613
85	Exertional dyspnea (HP:0002875)	1.89326943
86	Nephronophthisis (HP:0000090)	1.88945872
87	Congenital, generalized hypertrichosis (HP:0004540)	1.88133918
88	Ketosis (HP:0001946)	1.87540830
89	Respiratory failure (HP:0002878)	1.86129810
90	Abnormality of male internal genitalia (HP:0000022)	1.85736679
91	Exercise intolerance (HP:0003546)	1.85614391
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.85272800
93	Emotional lability (HP:0000712)	1.83493676
94	Retinal dysplasia (HP:0007973)	1.82636242
95	Recurrent bronchitis (HP:0002837)	1.82401763
96	Abnormality of serum amino acid levels (HP:0003112)	1.80514200
97	Cerebral palsy (HP:0100021)	1.80319454
98	Medial flaring of the eyebrow (HP:0010747)	1.79311910
99	Prostate neoplasm (HP:0100787)	1.78767263
100	Muscle fiber atrophy (HP:0100295)	1.77940883

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.43774623
2	TXK	3.86574883
3	MAP4K2	3.55413952
4	TAOK3	3.46098980
5	BCKDK	3.24622357
6	KDR	3.09142635
7	TLK1	2.90873361
8	ZAK	2.82909220
9	VRK2	2.35112720
10	NUAK1	2.06411352
11	SRPK1	2.03141568
12	MAP4K1	1.83526287
13	LIMK1	1.76594443
14	MAPKAPK3	1.75833645
15	ADRBK2	1.70846687
16	EIF2AK3	1.66380114
17	VRK1	1.64152667
18	TRIM28	1.63482110
19	TIE1	1.56128704
20	BCR	1.55360122
21	ERBB3	1.53604591
22	TESK1	1.52823501
23	BUB1	1.51563253
24	CDK19	1.47651908
25	GRK1	1.47615874
26	MAP2K7	1.44187019
27	ITK	1.39643106
28	CSNK1G3	1.33406431
29	TEC	1.30636096
30	GRK6	1.19314056
31	CSF1R	1.16321413
32	DAPK1	1.12396202
33	FES	1.07673955
34	CSNK1A1L	1.06581181
35	RPS6KA4	1.06116180
36	STK16	1.05001132
37	SCYL2	1.04418197
38	SYK	1.02921917
39	WNK3	1.01743069
40	IKBKB	0.99542785
41	NEK1	0.99421369
42	FRK	0.98546405
43	MAP3K4	0.97261692
44	KIT	0.96393281
45	MST4	0.95575021
46	TBK1	0.94915756
47	BMPR1B	0.94382748
48	CSNK1G1	0.93153427
49	CSNK1G2	0.92672082
50	RPS6KA5	0.89362684
51	MAP3K14	0.87191486
52	OXSR1	0.84808843
53	IKBKE	0.83863825
54	LCK	0.80471102
55	PINK1	0.76977161
56	MATK	0.76957571
57	PRKCQ	0.72606419
58	LYN	0.72263186
59	MAP2K2	0.71928900
60	WNK4	0.70882117
61	TNK2	0.70407611
62	PLK4	0.69578371
63	GRK7	0.68416379
64	MAPKAPK5	0.68060956
65	PIM2	0.68002484
66	CAMKK2	0.67715105
67	FLT3	0.66651751
68	BTK	0.65330391
69	TSSK6	0.60235144
70	MAPK13	0.58518508
71	EIF2AK2	0.57563500
72	PLK3	0.54674387
73	IGF1R	0.49489479
74	SIK3	0.49202038
75	BMPR2	0.48606910
76	INSRR	0.46215441
77	MKNK1	0.45593114
78	ATR	0.44809224
79	MAP2K6	0.44770661
80	PLK2	0.44564815
81	JAK3	0.43633487
82	MAP3K12	0.43223762
83	ABL1	0.42277332
84	DYRK2	0.41857277
85	GRK5	0.40062481
86	CCNB1	0.39631821
87	AURKA	0.39366937
88	AURKB	0.36040157
89	PHKG2	0.33703277
90	PHKG1	0.33703277
91	ACVR1B	0.33298449
92	ADRBK1	0.33245750
93	PASK	0.31712665
94	CSNK2A1	0.31652055
95	PLK1	0.31199449
96	ZAP70	0.29797944
97	MUSK	0.29311644
98	CDK8	0.27575369
99	EGFR	0.26807579
100	PIM1	0.25886953

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.25712306
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.23665284
3	Graft-versus-host disease_Homo sapiens_hsa05332	2.98101094
4	Allograft rejection_Homo sapiens_hsa05330	2.88497063
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.83729195
6	Asthma_Homo sapiens_hsa05310	2.82367832
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.60563661
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.46832512
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.44069780
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33988075
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.26012285
12	RNA polymerase_Homo sapiens_hsa03020	2.25744822
13	Parkinsons disease_Homo sapiens_hsa05012	2.03123492
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02314638
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.73839226
16	Protein export_Homo sapiens_hsa03060	1.73412035
17	Phototransduction_Homo sapiens_hsa04744	1.65902758
18	Homologous recombination_Homo sapiens_hsa03440	1.54414511
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.53456877
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51574613
21	DNA replication_Homo sapiens_hsa03030	1.49222787
22	Mismatch repair_Homo sapiens_hsa03430	1.45554324
23	Base excision repair_Homo sapiens_hsa03410	1.42298675
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41988478
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41488744
26	Spliceosome_Homo sapiens_hsa03040	1.40848286
27	Viral myocarditis_Homo sapiens_hsa05416	1.34114799
28	RNA degradation_Homo sapiens_hsa03018	1.33664852
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31187761
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30695746
31	Propanoate metabolism_Homo sapiens_hsa00640	1.24531747
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.21505629
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21187600
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15995689
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.10749953
36	Fatty acid elongation_Homo sapiens_hsa00062	1.10209732
37	Alzheimers disease_Homo sapiens_hsa05010	1.08352400
38	Huntingtons disease_Homo sapiens_hsa05016	1.06120632
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.05429191
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.04737262
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00954479
42	Purine metabolism_Homo sapiens_hsa00230	1.00338590
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.99164003
44	One carbon pool by folate_Homo sapiens_hsa00670	0.95681286
45	Butanoate metabolism_Homo sapiens_hsa00650	0.94836377
46	Peroxisome_Homo sapiens_hsa04146	0.94735639
47	Basal transcription factors_Homo sapiens_hsa03022	0.92751553
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91268642
49	RNA transport_Homo sapiens_hsa03013	0.91071954
50	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.90518134
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88447775
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86815786
53	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.86238401
54	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84991509
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.84577193
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82438409
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.80517243
58	Herpes simplex infection_Homo sapiens_hsa05168	0.79728468
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.79356269
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79176562
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76839690
62	Ribosome_Homo sapiens_hsa03010	0.76357040
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74624851
64	Caffeine metabolism_Homo sapiens_hsa00232	0.74419097
65	Shigellosis_Homo sapiens_hsa05131	0.72883312
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.70656335
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69873377
68	Sulfur metabolism_Homo sapiens_hsa00920	0.68955820
69	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.68719076
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66361405
71	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.64506288
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64159093
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63618133
74	Leishmaniasis_Homo sapiens_hsa05140	0.62670051
75	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62150133
76	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59256683
77	Regulation of autophagy_Homo sapiens_hsa04140	0.59202941
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.53817083
79	Metabolic pathways_Homo sapiens_hsa01100	0.49620242
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49276797
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48953945
82	Measles_Homo sapiens_hsa05162	0.48739062
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46582543
84	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46294270
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.46177605
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44739230
87	Legionellosis_Homo sapiens_hsa05134	0.44027248
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44016211
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43810310
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.42865745
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.40873585
92	Olfactory transduction_Homo sapiens_hsa04740	0.40829793
93	Salmonella infection_Homo sapiens_hsa05132	0.40101295
94	Carbon metabolism_Homo sapiens_hsa01200	0.33137066
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32834468
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32287014
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.31330484
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.29601376
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.24713499
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22775318

EIF4A1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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