EIF4A1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.42239255
2ATP synthesis coupled proton transport (GO:0015986)5.42239255
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40429032
4sequestering of actin monomers (GO:0042989)5.05344242
5Arp2/3 complex-mediated actin nucleation (GO:0034314)4.70420081
6protein neddylation (GO:0045116)4.42064454
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.41808274
8DNA deamination (GO:0045006)4.17082190
9actin nucleation (GO:0045010)4.14409120
10regulation of cellular amino acid metabolic process (GO:0006521)3.90502136
11cytidine deamination (GO:0009972)3.87035701
12cytidine metabolic process (GO:0046087)3.87035701
13cytidine catabolic process (GO:0006216)3.87035701
14respiratory electron transport chain (GO:0022904)3.74569120
15base-excision repair, AP site formation (GO:0006285)3.74007023
16electron transport chain (GO:0022900)3.71623569
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69851287
18water-soluble vitamin biosynthetic process (GO:0042364)3.68851267
19chaperone-mediated protein transport (GO:0072321)3.66950899
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63064363
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.61728835
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56670064
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52845693
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.50766540
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.50766540
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50307460
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50307460
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50307460
29mast cell activation (GO:0045576)3.48567507
30proteasome assembly (GO:0043248)3.46721999
31purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.45687087
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43736692
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.43085089
34positive regulation of lamellipodium assembly (GO:0010592)3.38365408
35purine deoxyribonucleotide catabolic process (GO:0009155)3.37921085
36protein-cofactor linkage (GO:0018065)3.37307296
37immunoglobulin mediated immune response (GO:0016064)3.37091125
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36808371
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.36808371
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35343778
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35343778
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.33266047
43deoxyribonucleotide catabolic process (GO:0009264)3.32575503
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32337411
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32325457
46pyrimidine ribonucleoside catabolic process (GO:0046133)3.29525226
47deoxyribose phosphate catabolic process (GO:0046386)3.28603119
48pseudouridine synthesis (GO:0001522)3.27457358
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.22814315
50termination of RNA polymerase III transcription (GO:0006386)3.22814315
51autophagic vacuole fusion (GO:0000046)3.18507658
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17376951
53regulation of cilium movement (GO:0003352)3.16584786
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16283373
55negative regulation of ligase activity (GO:0051352)3.16283373
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15299637
57deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.14428640
58ribosomal small subunit assembly (GO:0000028)3.10284216
59protein deneddylation (GO:0000338)3.08607082
60purine deoxyribonucleotide metabolic process (GO:0009151)3.07250542
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05657894
62adenosine metabolic process (GO:0046085)3.03899105
63neutrophil activation involved in immune response (GO:0002283)3.02240560
64S-adenosylmethionine metabolic process (GO:0046500)3.02071342
65branched-chain amino acid catabolic process (GO:0009083)3.01931450
66cullin deneddylation (GO:0010388)3.01085111
67antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.99670187
68negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99547555
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95888591
70regulation of cellular amine metabolic process (GO:0033238)2.95588089
71cytochrome complex assembly (GO:0017004)2.93636694
72sleep (GO:0030431)2.93586757
73hydrogen ion transmembrane transport (GO:1902600)2.92725610
74positive regulation of ligase activity (GO:0051351)2.91485871
75negative regulation of T cell apoptotic process (GO:0070233)2.91403670
76ATP biosynthetic process (GO:0006754)2.90833261
77mast cell activation involved in immune response (GO:0002279)2.90549866
78mast cell degranulation (GO:0043303)2.90549866
79negative regulation of heart rate (GO:0010459)2.89798581
80protein prenylation (GO:0018342)2.86284487
81prenylation (GO:0097354)2.86284487
82B cell mediated immunity (GO:0019724)2.85256826
83purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81762664
84protein complex biogenesis (GO:0070271)2.79144078
85deoxyribose phosphate metabolic process (GO:0019692)2.77375365
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75555606
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75192798
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75176709
892-deoxyribonucleotide metabolic process (GO:0009394)2.73637325
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73290150
91organic cation transport (GO:0015695)2.71302623
92proton transport (GO:0015992)2.70861940
93hydrogen transport (GO:0006818)2.68786515
94positive thymic T cell selection (GO:0045059)2.66783299
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66213066
96respiratory chain complex IV assembly (GO:0008535)2.65973553
97positive regulation of interleukin-1 beta secretion (GO:0050718)2.65363492
98metallo-sulfur cluster assembly (GO:0031163)2.65329697
99iron-sulfur cluster assembly (GO:0016226)2.65329697
100positive regulation of cell cycle arrest (GO:0071158)2.64327853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.16606953
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.34617703
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.27943521
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.15648131
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09135066
6ELF1_17652178_ChIP-ChIP_JURKAT_Human4.00754096
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76499022
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.50751558
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09804817
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95088150
11VDR_23849224_ChIP-Seq_CD4+_Human2.90218112
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80996157
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.78317844
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.48108902
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41211981
16FOXP3_21729870_ChIP-Seq_TREG_Human2.36378154
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33671094
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33241580
19IGF1R_20145208_ChIP-Seq_DFB_Human2.29472799
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26892198
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.07733129
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04674262
23CIITA_25753668_ChIP-Seq_RAJI_Human1.94807767
24VDR_22108803_ChIP-Seq_LS180_Human1.87981188
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.85705500
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84973908
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81857730
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79374682
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76200097
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.75969959
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75894423
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.73747652
33ELK1_19687146_ChIP-ChIP_HELA_Human1.67894476
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66795505
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65277669
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61827588
37ZNF274_21170338_ChIP-Seq_K562_Hela1.59931709
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50176546
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48668073
40MYB_26560356_Chip-Seq_TH2_Human1.47788374
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46742833
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.42749337
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37293282
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35979836
45GATA3_26560356_Chip-Seq_TH2_Human1.30858670
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29999146
47TP53_22573176_ChIP-Seq_HFKS_Human1.27644255
48DCP1A_22483619_ChIP-Seq_HELA_Human1.27534560
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26608997
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24460820
51MYC_18940864_ChIP-ChIP_HL60_Human1.24339601
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23181612
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23146208
54TTF2_22483619_ChIP-Seq_HELA_Human1.21730751
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.20486936
56AR_20517297_ChIP-Seq_VCAP_Human1.20430177
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19670892
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17237191
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16826731
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14994979
61GABP_19822575_ChIP-Seq_HepG2_Human1.14903351
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13973907
63IRF1_19129219_ChIP-ChIP_H3396_Human1.13942718
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13709061
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12645379
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11283905
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10503089
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08633618
69XRN2_22483619_ChIP-Seq_HELA_Human1.07409617
70SPI1_23547873_ChIP-Seq_NB4_Human1.06827136
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04219929
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.03826443
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.03637354
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03637354
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03500567
76GATA3_27048872_Chip-Seq_THYMUS_Human1.02526015
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01653312
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01001488
79TAF2_19829295_ChIP-Seq_ESCs_Human0.98744789
80STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98592713
81ERG_20517297_ChIP-Seq_VCAP_Human0.97993778
82BCL6_27268052_Chip-Seq_Bcells_Human0.94949787
83FUS_26573619_Chip-Seq_HEK293_Human0.94853840
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94386978
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93518796
86NCOR_22424771_ChIP-Seq_293T_Human0.93166007
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.91729549
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91580468
89PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91337007
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91180202
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.91061159
92HTT_18923047_ChIP-ChIP_STHdh_Human0.90868245
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90714920
94NANOG_20526341_ChIP-Seq_ESCs_Human0.90644458
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89138106
96CBP_20019798_ChIP-Seq_JUKART_Human0.89138106
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88917699
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88417097
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86174631
100HOXB7_26014856_ChIP-Seq_BT474_Human0.85827793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.68157463
2MP0001835_abnormal_antigen_presentation3.45738495
3MP0003724_increased_susceptibility_to3.36280987
4MP0003646_muscle_fatigue2.93410853
5MP0004147_increased_porphyrin_level2.68919872
6MP0006072_abnormal_retinal_apoptosis2.65491676
7MP0002102_abnormal_ear_morphology2.64289163
8MP0009785_altered_susceptibility_to2.55212273
9MP0002876_abnormal_thyroid_physiology2.40794823
10MP0002837_dystrophic_cardiac_calcinosis2.28637861
11MP0005000_abnormal_immune_tolerance2.26981592
12MP0002148_abnormal_hypersensitivity_rea2.25373400
13MP0009764_decreased_sensitivity_to2.20076721
14MP0005084_abnormal_gallbladder_morpholo2.15850110
15MP0009333_abnormal_splenocyte_physiolog2.14143329
16MP0002166_altered_tumor_susceptibility2.06989408
17MP0005670_abnormal_white_adipose1.94623828
18MP0005075_abnormal_melanosome_morpholog1.89947809
19MP0008875_abnormal_xenobiotic_pharmacok1.89473768
20MP0001800_abnormal_humoral_immune1.82740095
21MP0003195_calcinosis1.74348944
22MP0001905_abnormal_dopamine_level1.72558660
23MP0002006_tumorigenesis1.67682919
24MP0008995_early_reproductive_senescence1.65926756
25MP0009379_abnormal_foot_pigmentation1.65025244
26MP0003806_abnormal_nucleotide_metabolis1.64461626
27MP0006292_abnormal_olfactory_placode1.64232398
28MP0003786_premature_aging1.62939271
29MP0002723_abnormal_immune_serum1.61442118
30MP0002420_abnormal_adaptive_immunity1.53579685
31MP0008058_abnormal_DNA_repair1.53277425
32MP0002736_abnormal_nociception_after1.52839985
33MP0001819_abnormal_immune_cell1.52042554
34MP0008872_abnormal_physiological_respon1.49346515
35MP0002452_abnormal_antigen_presenting1.48871292
36MP0010155_abnormal_intestine_physiology1.48797049
37MP0005253_abnormal_eye_physiology1.46811989
38MP0003693_abnormal_embryo_hatching1.41509310
39MP0005025_abnormal_response_to1.38847800
40MP0005551_abnormal_eye_electrophysiolog1.31579322
41MP0005645_abnormal_hypothalamus_physiol1.31184945
42MP0005367_renal/urinary_system_phenotyp1.28925287
43MP0000516_abnormal_urinary_system1.28925287
44MP0001986_abnormal_taste_sensitivity1.28270314
45MP0005464_abnormal_platelet_physiology1.27997632
46MP0001984_abnormal_olfaction1.26807055
47MP0002160_abnormal_reproductive_system1.22929786
48MP0001968_abnormal_touch/_nociception1.22071802
49MP0005646_abnormal_pituitary_gland1.21945148
50MP0001188_hyperpigmentation1.21691297
51MP0005389_reproductive_system_phenotype1.18163597
52MP0003718_maternal_effect1.16764838
53MP0008877_abnormal_DNA_methylation1.14974279
54MP0001764_abnormal_homeostasis1.13660420
55MP0001845_abnormal_inflammatory_respons1.12113410
56MP0003763_abnormal_thymus_physiology1.12022913
57MP0001919_abnormal_reproductive_system1.10647247
58MP0000689_abnormal_spleen_morphology1.09321410
59MP0002277_abnormal_respiratory_mucosa1.07355814
60MP0000716_abnormal_immune_system1.07011465
61MP0002419_abnormal_innate_immunity1.06754680
62MP0005332_abnormal_amino_acid1.05943396
63MP0002398_abnormal_bone_marrow1.04292162
64MP0003880_abnormal_central_pattern1.02426385
65MP0001542_abnormal_bone_strength1.02293142
66MP0005410_abnormal_fertilization1.02281170
67MP0002722_abnormal_immune_system0.99320012
68MP0002272_abnormal_nervous_system0.99257847
69MP0002163_abnormal_gland_morphology0.96373386
70MP0006082_CNS_inflammation0.96079421
71MP0006036_abnormal_mitochondrial_physio0.95964965
72MP0003638_abnormal_response/metabolism_0.92435433
73MP0000372_irregular_coat_pigmentation0.91563265
74MP0003448_altered_tumor_morphology0.89994763
75MP0002429_abnormal_blood_cell0.89348493
76MP0001765_abnormal_ion_homeostasis0.88409249
77MP0000858_altered_metastatic_potential0.87337455
78MP0004885_abnormal_endolymph0.86465026
79MP0008469_abnormal_protein_level0.85652284
80MP0001661_extended_life_span0.85588180
81MP0001873_stomach_inflammation0.84758587
82MP0002138_abnormal_hepatobiliary_system0.84188186
83MP0009763_increased_sensitivity_to0.83645696
84MP0004957_abnormal_blastocyst_morpholog0.83308510
85MP0003075_altered_response_to0.81498336
86MP0004145_abnormal_muscle_electrophysio0.81237215
87MP0002019_abnormal_tumor_incidence0.80818381
88MP0000647_abnormal_sebaceous_gland0.79209712
89MP0005636_abnormal_mineral_homeostasis0.78952402
90MP0010368_abnormal_lymphatic_system0.78848396
91MP0003436_decreased_susceptibility_to0.78114791
92MP0009046_muscle_twitch0.77467613
93MP0010386_abnormal_urinary_bladder0.77029666
94MP0001970_abnormal_pain_threshold0.75779649
95MP0002938_white_spotting0.75682285
96MP0002405_respiratory_system_inflammati0.75678614
97MP0003283_abnormal_digestive_organ0.75015664
98MP0003252_abnormal_bile_duct0.74138688
99MP0003011_delayed_dark_adaptation0.73920038
100MP0001529_abnormal_vocalization0.73019070

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.90896474
2Hepatocellular necrosis (HP:0001404)4.47577183
3Mitochondrial inheritance (HP:0001427)4.39459368
4Increased hepatocellular lipid droplets (HP:0006565)4.25299152
5Acute necrotizing encephalopathy (HP:0006965)4.01298690
6Hepatic necrosis (HP:0002605)4.00978970
7Decreased central vision (HP:0007663)3.97241617
8Increased CSF lactate (HP:0002490)3.92071763
9Lipid accumulation in hepatocytes (HP:0006561)3.85890006
10Acute encephalopathy (HP:0006846)3.69112783
11Elevated erythrocyte sedimentation rate (HP:0003565)3.54886053
12Abnormal mitochondria in muscle tissue (HP:0008316)3.51307224
133-Methylglutaconic aciduria (HP:0003535)3.45427138
14Progressive macrocephaly (HP:0004481)3.44581009
15Increased intramyocellular lipid droplets (HP:0012240)3.13785631
16Severe combined immunodeficiency (HP:0004430)3.06960627
17Renal Fanconi syndrome (HP:0001994)3.05328777
18Abnormality of the prostate (HP:0008775)3.05111683
19Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97565746
20IgG deficiency (HP:0004315)2.96780996
21Cerebral edema (HP:0002181)2.93347150
22Lactic acidosis (HP:0003128)2.87756570
23Hyperglycinemia (HP:0002154)2.83876860
24Exertional dyspnea (HP:0002875)2.82728825
25Hypoproteinemia (HP:0003075)2.71627735
26Increased serum lactate (HP:0002151)2.70585809
27Pancytopenia (HP:0001876)2.68138104
28Type I transferrin isoform profile (HP:0003642)2.65382512
29Increased muscle lipid content (HP:0009058)2.55356010
30Prostate neoplasm (HP:0100787)2.54898191
31Optic disc pallor (HP:0000543)2.51507548
32Methylmalonic acidemia (HP:0002912)2.51332119
33Autoimmune hemolytic anemia (HP:0001890)2.51161795
34Microretrognathia (HP:0000308)2.48833704
35Attenuation of retinal blood vessels (HP:0007843)2.47625113
36Abnormal protein glycosylation (HP:0012346)2.42117886
37Abnormal glycosylation (HP:0012345)2.42117886
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42117886
39Abnormal protein N-linked glycosylation (HP:0012347)2.42117886
40Tinnitus (HP:0000360)2.40017059
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38435578
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37289638
43Respiratory failure (HP:0002878)2.36844833
44Abnormal number of erythroid precursors (HP:0012131)2.35238895
45Combined immunodeficiency (HP:0005387)2.32398236
46Chronic sinusitis (HP:0011109)2.31613779
47Erythema (HP:0010783)2.30623294
48Congenital stationary night blindness (HP:0007642)2.30424733
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25495485
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25495485
51Pancreatic cysts (HP:0001737)2.25484249
52Abnormality of serum amino acid levels (HP:0003112)2.23934255
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23574142
54Abnormality of cells of the erythroid lineage (HP:0012130)2.23496438
55Abnormality of glycine metabolism (HP:0010895)2.22128775
56Abnormality of serine family amino acid metabolism (HP:0010894)2.22128775
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20775524
58Congenital, generalized hypertrichosis (HP:0004540)2.18536718
59Generalized aminoaciduria (HP:0002909)2.16449595
60Renal cortical cysts (HP:0000803)2.15272202
61Abolished electroretinogram (ERG) (HP:0000550)2.14745470
62Hyperammonemia (HP:0001987)2.14558150
63Abnormality of alanine metabolism (HP:0010916)2.14468989
64Hyperalaninemia (HP:0003348)2.14468989
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14468989
66True hermaphroditism (HP:0010459)2.12019327
67Lethargy (HP:0001254)2.11503240
68Leukodystrophy (HP:0002415)2.10713009
69Oral leukoplakia (HP:0002745)2.07922677
70Stenosis of the external auditory canal (HP:0000402)2.07540832
71Rectovaginal fistula (HP:0000143)2.07068986
72Rectal fistula (HP:0100590)2.07068986
73Short tibia (HP:0005736)2.06993889
74Thyroiditis (HP:0100646)2.04577736
75Alveolar cell carcinoma (HP:0006519)2.01715611
76Facial diplegia (HP:0001349)2.00122911
77Respiratory difficulties (HP:0002880)1.97565903
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.95604022
79Absent/shortened dynein arms (HP:0200106)1.95604022
80Abnormal respiratory epithelium morphology (HP:0012253)1.95231219
81Abnormal respiratory motile cilium morphology (HP:0005938)1.95231219
82Agitation (HP:0000713)1.95083007
83CNS demyelination (HP:0007305)1.94894201
84Methylmalonic aciduria (HP:0012120)1.91902891
85Type 2 muscle fiber atrophy (HP:0003554)1.90863550
86Abnormality of eosinophils (HP:0001879)1.87055246
87Cerebral palsy (HP:0100021)1.86788130
88Type II lissencephaly (HP:0007260)1.86464867
89Abnormality of renal resorption (HP:0011038)1.85661984
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.85281313
91Exercise intolerance (HP:0003546)1.85041715
92Pancreatic fibrosis (HP:0100732)1.79145730
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.79114506
94Spastic paraparesis (HP:0002313)1.78545478
95Glycosuria (HP:0003076)1.78073207
96Abnormality of urine glucose concentration (HP:0011016)1.78073207
97Abnormality of midbrain morphology (HP:0002418)1.75239362
98Molar tooth sign on MRI (HP:0002419)1.75239362
99IgM deficiency (HP:0002850)1.75173614
100Mesangial abnormality (HP:0001966)1.73617274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.84296662
2TLK13.79664052
3MAP4K23.42679468
4TIE13.38386651
5ZAK3.19873248
6KDR2.85303049
7NUAK12.83482338
8BCKDK2.75711618
9VRK22.75498579
10TAOK32.74559969
11TXK2.69607363
12CDK192.67814245
13BMPR22.45189810
14MAP3K122.39399079
15STK162.23034407
16EIF2AK31.68369902
17KIT1.66658618
18OXSR11.65350393
19GRK11.64373334
20VRK11.61498365
21BUB11.60788907
22SCYL21.58093576
23MAP4K11.55464319
24LIMK11.45324112
25CSF1R1.41818096
26TEC1.40425360
27PASK1.37498124
28TESK11.36264344
29ITK1.31992699
30FLT31.26675080
31ADRBK21.24921235
32IKBKE1.22526578
33DAPK11.18983112
34IKBKB1.14858204
35MYLK1.11447548
36CSNK1G31.08078766
37MST41.04387966
38ARAF0.99894440
39PIM20.95744276
40WNK40.90304691
41LYN0.89834955
42MAP2K70.87886754
43TAF10.87262396
44SYK0.87127699
45CSNK1G10.82272441
46NEK10.81667748
47FRK0.81312113
48CSNK1A1L0.81022795
49RPS6KA50.80431942
50MAP3K140.79623353
51PRKCQ0.74510477
52PIK3CA0.73531044
53CSNK1G20.72465055
54LCK0.71386801
55EPHA30.70849686
56DAPK30.69499863
57GRK60.65586975
58EIF2AK20.65364438
59BTK0.64563679
60MATK0.64410239
61MAPK130.64274678
62TBK10.64140646
63DYRK20.62195569
64GRK70.60915142
65ERBB30.60767833
66CAMKK20.60647139
67SRPK10.60071564
68MAP2K20.59203003
69ZAP700.56222537
70PLK40.56195887
71AURKA0.54588997
72LMTK20.49931150
73FES0.47716975
74AURKB0.45924340
75PHKG20.43927480
76PHKG10.43927480
77STK390.41956202
78INSRR0.41317986
79GRK50.40152650
80JAK30.39800957
81MAPKAPK50.38777582
82CDK80.38486546
83CSNK2A10.38259482
84PAK10.36681555
85ROCK10.36387497
86IGF1R0.35701280
87DAPK20.34900218
88PBK0.33484825
89TSSK60.29441413
90CAMKK10.27260246
91CCNB10.26762928
92ABL10.26107316
93STK100.25883916
94PLK10.25665947
95ADRBK10.24710597
96PRKCA0.23193805
97NME20.22902570
98MKNK10.21701674
99ATR0.20137763
100CSK0.19667514

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.41124025
2Asthma_Homo sapiens_hsa053103.56258089
3Graft-versus-host disease_Homo sapiens_hsa053323.30736859
4Allograft rejection_Homo sapiens_hsa053303.29305495
5Oxidative phosphorylation_Homo sapiens_hsa001903.26940737
6Autoimmune thyroid disease_Homo sapiens_hsa053203.10531720
7Type I diabetes mellitus_Homo sapiens_hsa049402.88859389
8Parkinsons disease_Homo sapiens_hsa050122.70112945
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.61160667
10Ribosome_Homo sapiens_hsa030102.41395114
11RNA polymerase_Homo sapiens_hsa030202.22827436
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13902564
13Antigen processing and presentation_Homo sapiens_hsa046122.10794753
14Primary immunodeficiency_Homo sapiens_hsa053402.08464082
15Systemic lupus erythematosus_Homo sapiens_hsa053222.06312492
16Rheumatoid arthritis_Homo sapiens_hsa053231.87031832
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80607629
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64913486
19Alzheimers disease_Homo sapiens_hsa050101.64066065
20Huntingtons disease_Homo sapiens_hsa050161.58311005
21Viral myocarditis_Homo sapiens_hsa054161.55425623
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43613296
23Nitrogen metabolism_Homo sapiens_hsa009101.37729986
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34567922
25Hematopoietic cell lineage_Homo sapiens_hsa046401.34344091
26One carbon pool by folate_Homo sapiens_hsa006701.32162743
27Phototransduction_Homo sapiens_hsa047441.31693133
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30994319
29Protein export_Homo sapiens_hsa030601.29165696
30Cardiac muscle contraction_Homo sapiens_hsa042601.25280276
31Staphylococcus aureus infection_Homo sapiens_hsa051501.24454145
32Spliceosome_Homo sapiens_hsa030401.22721272
33Fatty acid elongation_Homo sapiens_hsa000621.18630330
34Collecting duct acid secretion_Homo sapiens_hsa049661.17212744
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16711470
36Sulfur metabolism_Homo sapiens_hsa009201.14512769
37RNA degradation_Homo sapiens_hsa030181.12144739
38Leishmaniasis_Homo sapiens_hsa051401.06021639
39Homologous recombination_Homo sapiens_hsa034401.04267827
40Butanoate metabolism_Homo sapiens_hsa006500.96819678
41Pyrimidine metabolism_Homo sapiens_hsa002400.96167100
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93908091
43Basal transcription factors_Homo sapiens_hsa030220.93517178
44Purine metabolism_Homo sapiens_hsa002300.92091475
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90906136
46Propanoate metabolism_Homo sapiens_hsa006400.89428125
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88206611
48Shigellosis_Homo sapiens_hsa051310.84430158
49DNA replication_Homo sapiens_hsa030300.82796803
50Peroxisome_Homo sapiens_hsa041460.82459031
51RNA transport_Homo sapiens_hsa030130.81397929
52Mismatch repair_Homo sapiens_hsa034300.79589237
53Nucleotide excision repair_Homo sapiens_hsa034200.73073608
54Herpes simplex infection_Homo sapiens_hsa051680.69554909
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66534206
56Linoleic acid metabolism_Homo sapiens_hsa005910.66531179
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66367604
58Alcoholism_Homo sapiens_hsa050340.63342036
59Selenocompound metabolism_Homo sapiens_hsa004500.63254619
60Base excision repair_Homo sapiens_hsa034100.62177588
61Olfactory transduction_Homo sapiens_hsa047400.62010124
62Salmonella infection_Homo sapiens_hsa051320.58975755
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58274395
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57999727
65Tryptophan metabolism_Homo sapiens_hsa003800.56709542
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56014624
67Epstein-Barr virus infection_Homo sapiens_hsa051690.54769770
68Fanconi anemia pathway_Homo sapiens_hsa034600.53138036
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52301988
70T cell receptor signaling pathway_Homo sapiens_hsa046600.51469757
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50025019
72Caffeine metabolism_Homo sapiens_hsa002320.49083726
73Metabolic pathways_Homo sapiens_hsa011000.46540413
74Fatty acid biosynthesis_Homo sapiens_hsa000610.46181210
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46082517
76Steroid biosynthesis_Homo sapiens_hsa001000.45639341
77Non-homologous end-joining_Homo sapiens_hsa034500.44759827
78Phagosome_Homo sapiens_hsa041450.44590935
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42880593
80Arachidonic acid metabolism_Homo sapiens_hsa005900.40672929
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39636713
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39600941
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.39150367
84Legionellosis_Homo sapiens_hsa051340.38597924
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37426596
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36796306
87Chemical carcinogenesis_Homo sapiens_hsa052040.34456588
88Regulation of autophagy_Homo sapiens_hsa041400.32335866
89Influenza A_Homo sapiens_hsa051640.32035169
90Malaria_Homo sapiens_hsa051440.31588516
91p53 signaling pathway_Homo sapiens_hsa041150.29136800
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.28653707
93beta-Alanine metabolism_Homo sapiens_hsa004100.27579573
94Tuberculosis_Homo sapiens_hsa051520.27225377
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26732821
96Fatty acid metabolism_Homo sapiens_hsa012120.25401621
97Vibrio cholerae infection_Homo sapiens_hsa051100.24821118
98Nicotine addiction_Homo sapiens_hsa050330.24664930
99Toxoplasmosis_Homo sapiens_hsa051450.23684785
100Measles_Homo sapiens_hsa051620.22637694

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