ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	6.94248556
2	chaperone-mediated protein transport (GO:0072321)	6.73745373
3	rRNA modification (GO:0000154)	6.43493564
4	rRNA methylation (GO:0031167)	5.67582323
5	regulation of skeletal muscle contraction (GO:0014819)	5.58260490
6	response to gravity (GO:0009629)	5.46855838
7	maturation of SSU-rRNA (GO:0030490)	5.32708091
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.20366484
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.20366484
10	NADH dehydrogenase complex assembly (GO:0010257)	5.20366484
11	ribosomal small subunit biogenesis (GO:0042274)	5.08927219
12	fusion of sperm to egg plasma membrane (GO:0007342)	4.98803252
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.94013488
14	ATP synthesis coupled proton transport (GO:0015986)	4.94013488
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.75572011
16	sperm motility (GO:0030317)	4.73031786
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.55199316
18	protein complex biogenesis (GO:0070271)	4.50346884
19	mitochondrial respiratory chain complex assembly (GO:0033108)	4.44081386
20	proteasome assembly (GO:0043248)	4.41185316
21	GTP biosynthetic process (GO:0006183)	4.37530704
22	protein-cofactor linkage (GO:0018065)	4.31242216
23	viral transcription (GO:0019083)	4.14406355
24	grooming behavior (GO:0007625)	4.06218276
25	UTP biosynthetic process (GO:0006228)	4.03856291
26	plasma membrane fusion (GO:0045026)	4.00665859
27	ribosomal small subunit assembly (GO:0000028)	3.99658701
28	respiratory electron transport chain (GO:0022904)	3.97502626
29	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.96899658
30	DNA deamination (GO:0045006)	3.92878926
31	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.91918640
32	translational elongation (GO:0006414)	3.89978792
33	electron transport chain (GO:0022900)	3.89782676
34	translational termination (GO:0006415)	3.85559409
35	UTP metabolic process (GO:0046051)	3.77415807
36	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.77203917
37	regulation of centriole replication (GO:0046599)	3.73395264
38	protein targeting to mitochondrion (GO:0006626)	3.67571894
39	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.67104273
40	negative regulation of JAK-STAT cascade (GO:0046426)	3.64554705
41	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.64255096
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.64054026
43	negative regulation of muscle hypertrophy (GO:0014741)	3.62702455
44	RNA destabilization (GO:0050779)	3.62321393
45	outer ear morphogenesis (GO:0042473)	3.59778270
46	cellular response to exogenous dsRNA (GO:0071360)	3.55616341
47	regulation of cilium movement (GO:0003352)	3.53510100
48	sperm-egg recognition (GO:0035036)	3.49054588
49	DNA packaging (GO:0006323)	3.47512719
50	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46004267
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46004267
52	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.45276345
53	ATP biosynthetic process (GO:0006754)	3.44864347
54	cardiovascular system development (GO:0072358)	3.44543530
55	CTP biosynthetic process (GO:0006241)	3.42066244
56	CTP metabolic process (GO:0046036)	3.42066244
57	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.37852405
58	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.32452355
59	regulation of DNA endoreduplication (GO:0032875)	3.30926152
60	multicellular organism reproduction (GO:0032504)	3.30766458
61	skeletal muscle adaptation (GO:0043501)	3.29928537
62	chromosome condensation (GO:0030261)	3.29573431
63	spermatid development (GO:0007286)	3.26093598
64	protein neddylation (GO:0045116)	3.24781390
65	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.23049415
66	establishment of protein localization to mitochondrion (GO:0072655)	3.22644397
67	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.22252108
68	cotranslational protein targeting to membrane (GO:0006613)	3.21317620
69	translation (GO:0006412)	3.21201384
70	pseudouridine synthesis (GO:0001522)	3.21130105
71	striated muscle atrophy (GO:0014891)	3.20867300
72	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.19455636
73	protein targeting to ER (GO:0045047)	3.19261802
74	termination of RNA polymerase III transcription (GO:0006386)	3.17948748
75	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.17948748
76	cellular component biogenesis (GO:0044085)	3.17485281
77	protein localization to mitochondrion (GO:0070585)	3.16464180
78	binding of sperm to zona pellucida (GO:0007339)	3.15936788
79	cell wall macromolecule metabolic process (GO:0044036)	3.14821837
80	rRNA processing (GO:0006364)	3.13959063
81	guanosine-containing compound biosynthetic process (GO:1901070)	3.13289752
82	acrosome reaction (GO:0007340)	3.11456480
83	cellular protein complex disassembly (GO:0043624)	3.09823870
84	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.07819947
85	regulation of germinal center formation (GO:0002634)	3.07719345
86	muscle atrophy (GO:0014889)	3.05727604
87	rRNA metabolic process (GO:0016072)	3.05251275
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02552200
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01662663
90	protein localization to endoplasmic reticulum (GO:0070972)	3.00749011
91	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.00537178
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.98062014
93	ribonucleoprotein complex biogenesis (GO:0022613)	2.94519622
94	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.93523134
95	viral life cycle (GO:0019058)	2.92676078
96	reproduction (GO:0000003)	2.92560686
97	protein maturation by protein folding (GO:0022417)	2.90360895
98	ubiquinone biosynthetic process (GO:0006744)	2.86155717
99	mesonephros development (GO:0001823)	2.85759932
100	positive regulation of interleukin-8 secretion (GO:2000484)	2.84204750

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	7.77201023
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.04414050
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.78140581
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.11803245
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.06335115
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02506087
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.79870084
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75240191
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62516521
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56734138
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55456738
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.54032820
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.50024637
14	VDR_22108803_ChIP-Seq_LS180_Human	2.32303679
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.31902267
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.12928020
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11424880
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.02602361
19	XRN2_22483619_ChIP-Seq_HELA_Human	2.01767436
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97456902
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84544210
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.80928336
23	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.79101742
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.74205948
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.72439773
26	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.70719499
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69398288
28	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.68057562
29	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.67579530
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67407794
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.64149777
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63502230
33	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.63425411
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.63377246
35	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.62197206
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58892830
37	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.58461424
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.52611771
39	FUS_26573619_Chip-Seq_HEK293_Human	1.52115777
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.50505204
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50321513
42	ERA_21632823_ChIP-Seq_H3396_Human	1.48296037
43	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.48136535
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47287340
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41654003
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40883786
47	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.39250987
48	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.37220297
49	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.35599349
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.34881821
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34132446
52	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.33775448
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.32308881
54	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27558275
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26814726
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25846236
57	P68_20966046_ChIP-Seq_HELA_Human	1.25779362
58	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.24039205
59	BCOR_27268052_Chip-Seq_Bcells_Human	1.21606645
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20570212
61	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.18285661
62	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.15339779
63	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.13903075
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.11782090
65	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.11375932
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10872229
67	E2F1_20622854_ChIP-Seq_HELA_Human	1.10211298
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10206842
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.09932187
70	P300_27268052_Chip-Seq_Bcells_Human	1.06620256
71	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.06449871
72	PHF8_20622854_ChIP-Seq_HELA_Human	1.05326742
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04843526
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.03691976
75	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.02878370
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02469365
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01293093
78	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00842793
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00243635
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.99916699
81	RAC3_21632823_ChIP-Seq_H3396_Human	0.98727706
82	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.97704031
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97345503
84	MYC_18940864_ChIP-ChIP_HL60_Human	0.96513599
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.95070823
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94816274
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94624453
88	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.91813483
89	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.91412499
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89384432
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89315879
92	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.88752797
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88116710
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.87935046
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85893439
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.85201334
97	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85037030
98	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.84929357
99	SA1_27219007_Chip-Seq_Bcells_Human	0.84911007
100	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83067184

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.61800831
2	MP0002138_abnormal_hepatobiliary_system	3.43993735
3	MP0000678_abnormal_parathyroid_gland	3.23141519
4	MP0000049_abnormal_middle_ear	3.10526021
5	MP0001348_abnormal_lacrimal_gland	3.01040935
6	MP0009053_abnormal_anal_canal	2.48802321
7	MP0005084_abnormal_gallbladder_morpholo	2.47326178
8	MP0005670_abnormal_white_adipose	2.39570390
9	MP0003878_abnormal_ear_physiology	2.33124257
10	MP0005377_hearing/vestibular/ear_phenot	2.33124257
11	MP0002160_abnormal_reproductive_system	2.31149343
12	MP0005379_endocrine/exocrine_gland_phen	2.13254938
13	MP0006292_abnormal_olfactory_placode	1.99015688
14	MP0008789_abnormal_olfactory_epithelium	1.91824439
15	MP0005646_abnormal_pituitary_gland	1.87999500
16	MP0006072_abnormal_retinal_apoptosis	1.87575407
17	MP0003698_abnormal_male_reproductive	1.81918140
18	MP0005671_abnormal_response_to	1.80328840
19	MP0001929_abnormal_gametogenesis	1.76255199
20	MP0008058_abnormal_DNA_repair	1.75481172
21	MP0004145_abnormal_muscle_electrophysio	1.74412925
22	MP0004134_abnormal_chest_morphology	1.72392659
23	MP0003718_maternal_effect	1.71949198
24	MP0010030_abnormal_orbit_morphology	1.70330386
25	MP0005389_reproductive_system_phenotype	1.67414255
26	MP0004036_abnormal_muscle_relaxation	1.66540189
27	MP0008932_abnormal_embryonic_tissue	1.64663030
28	MP0003879_abnormal_hair_cell	1.59587547
29	MP0005083_abnormal_biliary_tract	1.53727636
30	MP0001905_abnormal_dopamine_level	1.49159215
31	MP0009379_abnormal_foot_pigmentation	1.48783138
32	MP0002108_abnormal_muscle_morphology	1.48617148
33	MP0000747_muscle_weakness	1.43809590
34	MP0010368_abnormal_lymphatic_system	1.37324102
35	MP0004885_abnormal_endolymph	1.35102723
36	MP0003786_premature_aging	1.34392323
37	MP0002282_abnormal_trachea_morphology	1.34194966
38	MP0002210_abnormal_sex_determination	1.33957178
39	MP0001968_abnormal_touch/_nociception	1.32035080
40	MP0002269_muscular_atrophy	1.31040601
41	MP0003077_abnormal_cell_cycle	1.30340072
42	MP0009250_abnormal_appendicular_skeleto	1.29012782
43	MP0001879_abnormal_lymphatic_vessel	1.28596113
44	MP0005257_abnormal_intraocular_pressure	1.24580150
45	MP0003646_muscle_fatigue	1.24053094
46	MP0004957_abnormal_blastocyst_morpholog	1.22348662
47	MP0002089_abnormal_postnatal_growth/wei	1.19002253
48	MP0001485_abnormal_pinna_reflex	1.14603414
49	MP0006036_abnormal_mitochondrial_physio	1.14571826
50	MP0003806_abnormal_nucleotide_metabolis	1.14266094
51	MP0001145_abnormal_male_reproductive	1.13521908
52	MP0002876_abnormal_thyroid_physiology	1.13420623
53	MP0000467_abnormal_esophagus_morphology	1.12596258
54	MP0001919_abnormal_reproductive_system	1.10562587
55	MP0002095_abnormal_skin_pigmentation	1.09489803
56	MP0000653_abnormal_sex_gland	1.09480828
57	MP0002161_abnormal_fertility/fecundity	1.07752221
58	MP0003693_abnormal_embryo_hatching	1.03343980
59	MP0000759_abnormal_skeletal_muscle	1.02616426
60	MP0008872_abnormal_physiological_respon	1.02117676
61	MP0009765_abnormal_xenobiotic_induced	1.01311066
62	MP0003938_abnormal_ear_development	1.00257132
63	MP0001963_abnormal_hearing_physiology	0.93370635
64	MP0000230_abnormal_systemic_arterial	0.91675741
65	MP0008775_abnormal_heart_ventricle	0.91238729
66	MP0003937_abnormal_limbs/digits/tail_de	0.90720375
67	MP0001529_abnormal_vocalization	0.89868594
68	MP0003183_abnormal_peptide_metabolism	0.89634444
69	MP0004133_heterotaxia	0.89300815
70	MP0002163_abnormal_gland_morphology	0.87874538
71	MP0002736_abnormal_nociception_after	0.87712664
72	MP0005187_abnormal_penis_morphology	0.87103331
73	MP0002938_white_spotting	0.86379049
74	MP0002932_abnormal_joint_morphology	0.86327903
75	MP0000750_abnormal_muscle_regeneration	0.86276629
76	MP0000749_muscle_degeneration	0.84786338
77	MP0002148_abnormal_hypersensitivity_rea	0.84309163
78	MP0000163_abnormal_cartilage_morphology	0.83607087
79	MP0000631_abnormal_neuroendocrine_gland	0.82596184
80	MP0003959_abnormal_lean_body	0.79813919
81	MP0001765_abnormal_ion_homeostasis	0.76916676
82	MP0000026_abnormal_inner_ear	0.76912339
83	MP0005499_abnormal_olfactory_system	0.76530472
84	MP0005394_taste/olfaction_phenotype	0.76530472
85	MP0002109_abnormal_limb_morphology	0.75037793
86	MP0005167_abnormal_blood-brain_barrier	0.74799666
87	MP0000685_abnormal_immune_system	0.74367464
88	MP0002234_abnormal_pharynx_morphology	0.74136572
89	MP0001440_abnormal_grooming_behavior	0.72723701
90	MP0009745_abnormal_behavioral_response	0.72507733
91	MP0002115_abnormal_skeleton_extremities	0.71039784
92	MP0004142_abnormal_muscle_tone	0.70970900
93	MP0008007_abnormal_cellular_replicative	0.69206068
94	MP0001486_abnormal_startle_reflex	0.68783408
95	MP0000613_abnormal_salivary_gland	0.68469315
96	MP0006276_abnormal_autonomic_nervous	0.66669588
97	MP0002837_dystrophic_cardiac_calcinosis	0.65669979
98	MP0001119_abnormal_female_reproductive	0.64897059
99	MP0002822_catalepsy	0.64546953
100	MP0009780_abnormal_chondrocyte_physiolo	0.63907492

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjunctival hamartoma (HP:0100780)	5.35012835
2	Acute necrotizing encephalopathy (HP:0006965)	4.26415639
3	Severe visual impairment (HP:0001141)	4.22998131
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.86742157
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.86154514
6	Absent/shortened dynein arms (HP:0200106)	3.86154514
7	Mitochondrial inheritance (HP:0001427)	3.78946598
8	Hamartoma of the eye (HP:0010568)	3.68905235
9	Acute encephalopathy (HP:0006846)	3.61871794
10	Abnormality of the middle phalanges of the toes (HP:0010183)	3.57352438
11	Progressive macrocephaly (HP:0004481)	3.47321845
12	Absent phalangeal crease (HP:0006109)	3.40437194
13	Increased CSF lactate (HP:0002490)	3.31086479
14	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.17830197
15	Symphalangism affecting the phalanges of the hand (HP:0009773)	3.17021023
16	Abnormality of the fetal cardiovascular system (HP:0010948)	3.14250138
17	Abnormal umbilical cord blood vessels (HP:0011403)	3.14250138
18	Single umbilical artery (HP:0001195)	3.14250138
19	Hepatocellular necrosis (HP:0001404)	3.11134314
20	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.07426670
21	Abnormality of the 4th metacarpal (HP:0010012)	3.07057498
22	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.02262995
23	Absent thumb (HP:0009777)	2.87532179
24	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.80624408
25	Hepatic necrosis (HP:0002605)	2.77965742
26	Hypoplasia of the radius (HP:0002984)	2.73613703
27	Tubulointerstitial nephritis (HP:0001970)	2.70310665
28	Palpebral edema (HP:0100540)	2.70104337
29	Bone cyst (HP:0012062)	2.67986797
30	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.66455301
31	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.65563154
32	Meningioma (HP:0002858)	2.64827705
33	Cerebral edema (HP:0002181)	2.64064538
34	3-Methylglutaconic aciduria (HP:0003535)	2.59166805
35	Abnormal finger flexion creases (HP:0006143)	2.58739045
36	Fibular aplasia (HP:0002990)	2.57492075
37	Pancreatic cysts (HP:0001737)	2.56095461
38	Reticulocytopenia (HP:0001896)	2.45785166
39	Renal Fanconi syndrome (HP:0001994)	2.42622785
40	Abnormal number of erythroid precursors (HP:0012131)	2.39197537
41	Reduced subcutaneous adipose tissue (HP:0003758)	2.39186812
42	Increased serum lactate (HP:0002151)	2.38560234
43	Forearm undergrowth (HP:0009821)	2.34386507
44	Pendular nystagmus (HP:0012043)	2.33482637
45	Lactic acidosis (HP:0003128)	2.31776607
46	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.31503947
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.31309749
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31309749
49	Furrowed tongue (HP:0000221)	2.30759528
50	Short femoral neck (HP:0100864)	2.28772326
51	Respiratory failure (HP:0002878)	2.25475618
52	Short middle phalanx of the 5th finger (HP:0004220)	2.24803969
53	Adenoma sebaceum (HP:0009720)	2.23521718
54	Angiofibromas (HP:0010615)	2.23521718
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22115027
56	Paralysis (HP:0003470)	2.20841980
57	Abnormality of cells of the erythroid lineage (HP:0012130)	2.20790642
58	Pancreatic fibrosis (HP:0100732)	2.19649001
59	Esophageal atresia (HP:0002032)	2.19556084
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.17306305
61	Abnormality of macular pigmentation (HP:0008002)	2.17008611
62	Broad distal phalanx of finger (HP:0009836)	2.15845110
63	Microretrognathia (HP:0000308)	2.15665908
64	Cavernous hemangioma (HP:0001048)	2.11851180
65	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.08505536
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.07461150
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.07461150
68	Exercise intolerance (HP:0003546)	2.05476374
69	Abnormality of midbrain morphology (HP:0002418)	2.02424751
70	Molar tooth sign on MRI (HP:0002419)	2.02424751
71	Spinal cord lesions (HP:0100561)	2.02042550
72	Syringomyelia (HP:0003396)	2.02042550
73	Broad hallux (HP:0010055)	2.01140657
74	Ulnar deviation of the wrist (HP:0003049)	1.97135706
75	Abnormality of the umbilical cord (HP:0010881)	1.94785400
76	Short tibia (HP:0005736)	1.94774478
77	Abnormality of the phalanges of the hallux (HP:0010057)	1.94717237
78	Increased hepatocellular lipid droplets (HP:0006565)	1.94617788
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93112473
80	Distal arthrogryposis (HP:0005684)	1.92982930
81	Anencephaly (HP:0002323)	1.92922134
82	Hypoplasia of the uterus (HP:0000013)	1.92823010
83	Mesomelia (HP:0003027)	1.92172462
84	Abnormality of alanine metabolism (HP:0010916)	1.91115733
85	Hyperalaninemia (HP:0003348)	1.91115733
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91115733
87	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90472771
88	Increased purine levels (HP:0004368)	1.89611094
89	Hyperuricemia (HP:0002149)	1.89611094
90	Male infertility (HP:0003251)	1.89342908
91	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.87898539
92	Abnormal ciliary motility (HP:0012262)	1.86595058
93	Increased intramyocellular lipid droplets (HP:0012240)	1.85080319
94	Optic disc pallor (HP:0000543)	1.83238136
95	Occipital encephalocele (HP:0002085)	1.83113234
96	Round ear (HP:0100830)	1.80407236
97	Elevated erythrocyte sedimentation rate (HP:0003565)	1.79885414
98	Ectopic kidney (HP:0000086)	1.79496953
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79485801
100	Progressive muscle weakness (HP:0003323)	1.78725251

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	8.90182889
2	TIE1	4.56673726
3	PLK4	3.75674870
4	VRK2	3.51583547
5	INSRR	3.35473888
6	BCKDK	3.05576201
7	TESK2	2.71023676
8	NUAK1	2.42315058
9	TESK1	2.31371911
10	PHKG1	1.85078171
11	PHKG2	1.85078171
12	TLK1	1.60928807
13	TAF1	1.56365628
14	MAP3K11	1.46756529
15	LIMK1	1.38512390
16	ICK	1.35705649
17	MAPKAPK3	1.34528216
18	STK16	1.30492910
19	AURKA	1.30465600
20	PLK2	1.29577022
21	MAP2K2	1.28507564
22	PDK2	1.28236379
23	MAP4K2	1.25237722
24	ZAK	1.23590574
25	VRK1	1.19940437
26	MUSK	1.19633995
27	CSNK1G3	1.11222569
28	IKBKB	1.06080871
29	GRK6	1.02130521
30	SRPK1	1.01058021
31	CSNK1A1L	0.94304486
32	OBSCN	0.92664088
33	FES	0.90120603
34	RPS6KA4	0.88280838
35	DYRK2	0.88149048
36	PIK3CG	0.86499361
37	LMTK2	0.84627909
38	CDK7	0.84328979
39	ADRBK2	0.83962614
40	CSNK1G2	0.83145033
41	ABL2	0.80615858
42	MAP3K12	0.76846794
43	WNK4	0.75786653
44	GRK1	0.74928887
45	CCNB1	0.74219818
46	TRIM28	0.73351256
47	DYRK3	0.70824318
48	PIM2	0.70723092
49	NEK1	0.70181022
50	TAOK3	0.70148820
51	CSNK1G1	0.68389870
52	KDR	0.68068144
53	PINK1	0.67725600
54	BUB1	0.67266205
55	DAPK1	0.65992460
56	CDK19	0.64761607
57	RPS6KA5	0.62656451
58	CHEK2	0.61988633
59	CDC7	0.60339371
60	TYRO3	0.57810587
61	WNK1	0.55717661
62	BRD4	0.53427859
63	PAK6	0.52403228
64	SCYL2	0.51808288
65	IKBKE	0.50981120
66	BRSK1	0.48801834
67	CDK4	0.47896476
68	MAP2K7	0.47461242
69	EIF2AK2	0.46816568
70	TEC	0.45841200
71	NME1	0.44504588
72	ARAF	0.41377684
73	MAP3K8	0.41295828
74	PDPK1	0.40400074
75	MAPK11	0.40329631
76	PRKG2	0.39517694
77	LRRK2	0.38939374
78	CHEK1	0.38833595
79	NEK9	0.38219607
80	PIM1	0.37936376
81	CSNK2A1	0.35102130
82	ILK	0.34126882
83	AKT2	0.33183688
84	PDK1	0.33125492
85	IRAK1	0.32537562
86	PAK1	0.29666023
87	CSF1R	0.28017793
88	RPS6KC1	0.27696422
89	RPS6KL1	0.27696422
90	RPS6KA6	0.27589920
91	TBK1	0.27242251
92	PLK1	0.26637882
93	RPS6KA1	0.26624183
94	KIT	0.26323891
95	MAP3K14	0.25780129
96	PRKACA	0.25529007
97	ATR	0.25233495
98	CSNK1A1	0.23707214
99	DDR2	0.23622146
100	RPS6KA2	0.23250304

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.26877095
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.61483254
3	Parkinsons disease_Homo sapiens_hsa05012	4.10410019
4	Proteasome_Homo sapiens_hsa03050	3.44343096
5	Huntingtons disease_Homo sapiens_hsa05016	3.29619963
6	Alzheimers disease_Homo sapiens_hsa05010	3.02636763
7	RNA polymerase_Homo sapiens_hsa03020	2.83988924
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.71559042
9	DNA replication_Homo sapiens_hsa03030	2.68831089
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.45256749
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.17848224
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17799165
13	Base excision repair_Homo sapiens_hsa03410	2.10298198
14	Spliceosome_Homo sapiens_hsa03040	2.08517730
15	Pyrimidine metabolism_Homo sapiens_hsa00240	2.03311386
16	Sulfur relay system_Homo sapiens_hsa04122	1.99143115
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.98489568
18	Asthma_Homo sapiens_hsa05310	1.67260054
19	RNA transport_Homo sapiens_hsa03013	1.64139882
20	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.63298192
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.59973610
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59890525
23	Mismatch repair_Homo sapiens_hsa03430	1.56810806
24	One carbon pool by folate_Homo sapiens_hsa00670	1.47911136
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.45273439
26	Purine metabolism_Homo sapiens_hsa00230	1.42333948
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.30665141
28	Homologous recombination_Homo sapiens_hsa03440	1.28978428
29	RNA degradation_Homo sapiens_hsa03018	1.24561737
30	Olfactory transduction_Homo sapiens_hsa04740	1.15808652
31	Folate biosynthesis_Homo sapiens_hsa00790	1.04258288
32	Protein export_Homo sapiens_hsa03060	1.00583110
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00157405
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95313623
35	Phototransduction_Homo sapiens_hsa04744	0.83920083
36	Allograft rejection_Homo sapiens_hsa05330	0.82507137
37	Basal transcription factors_Homo sapiens_hsa03022	0.80590089
38	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77451456
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75989826
40	Antigen processing and presentation_Homo sapiens_hsa04612	0.75298030
41	Herpes simplex infection_Homo sapiens_hsa05168	0.73298166
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70450455
43	Graft-versus-host disease_Homo sapiens_hsa05332	0.70095862
44	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69429613
45	Metabolic pathways_Homo sapiens_hsa01100	0.67636622
46	Glutathione metabolism_Homo sapiens_hsa00480	0.67463546
47	Oocyte meiosis_Homo sapiens_hsa04114	0.64804559
48	Phenylalanine metabolism_Homo sapiens_hsa00360	0.64576028
49	Salivary secretion_Homo sapiens_hsa04970	0.59477068
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.59264429
51	Sulfur metabolism_Homo sapiens_hsa00920	0.56955178
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54921186
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54680490
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54657187
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53732398
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52221629
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.44559605
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.43503174
59	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42613801
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42245437
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41731955
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40477227
63	Peroxisome_Homo sapiens_hsa04146	0.38493672
64	Fatty acid elongation_Homo sapiens_hsa00062	0.38087873
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37880780
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35943400
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35428435
68	Regulation of autophagy_Homo sapiens_hsa04140	0.35247543
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33548156
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.33174876
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.32366097
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.31526577
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31432694
74	Carbon metabolism_Homo sapiens_hsa01200	0.31254159
75	Tight junction_Homo sapiens_hsa04530	0.30695559
76	Morphine addiction_Homo sapiens_hsa05032	0.28515510
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28223792
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28133637
79	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27045865
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25979952
81	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.25971604
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.25568605
83	Retinol metabolism_Homo sapiens_hsa00830	0.24541337
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.24212192
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24023191
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.23830117
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.23165533
88	Gastric acid secretion_Homo sapiens_hsa04971	0.22112143
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21997580
90	HTLV-I infection_Homo sapiens_hsa05166	0.21708083
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.21265551
92	Viral myocarditis_Homo sapiens_hsa05416	0.18902589
93	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.18502564
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.18411433
95	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.18343597
96	Pancreatic secretion_Homo sapiens_hsa04972	0.17848897
97	Melanoma_Homo sapiens_hsa05218	0.17327060
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.16290570
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.15704969
100	Linoleic acid metabolism_Homo sapiens_hsa00591	0.15517257

EIF4A1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »