EIF4A1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)5.82753347
2cytidine metabolic process (GO:0046087)5.82753347
3cytidine catabolic process (GO:0006216)5.82753347
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.43709552
5proteasome assembly (GO:0043248)5.06191792
6DNA deamination (GO:0045006)4.92070458
7DNA replication-dependent nucleosome organization (GO:0034723)4.84416126
8DNA replication-dependent nucleosome assembly (GO:0006335)4.84416126
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.82346391
10regulation of memory T cell differentiation (GO:0043380)4.67693322
11ubiquinone biosynthetic process (GO:0006744)4.14167899
12positive regulation of defense response to virus by host (GO:0002230)4.01228724
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95547447
14regulation of cellular amino acid metabolic process (GO:0006521)3.94381102
15rRNA modification (GO:0000154)3.93767407
16positive T cell selection (GO:0043368)3.77410359
17positive thymic T cell selection (GO:0045059)3.76453187
18positive regulation of B cell differentiation (GO:0045579)3.73968942
19purine nucleotide salvage (GO:0032261)3.72747552
20DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70113761
21protein complex biogenesis (GO:0070271)3.65620790
22ubiquinone metabolic process (GO:0006743)3.65433403
23negative T cell selection (GO:0043383)3.63621319
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63463075
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63463075
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63463075
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62586020
28positive regulation of gamma-delta T cell activation (GO:0046645)3.61873728
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.59381208
30negative regulation of ligase activity (GO:0051352)3.59381208
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.59226964
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.59226964
33rRNA catabolic process (GO:0016075)3.58710191
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57831616
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.57831616
36regulation of chronic inflammatory response (GO:0002676)3.57084426
37signal transduction involved in cell cycle checkpoint (GO:0072395)3.50243380
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.49131626
39NADH dehydrogenase complex assembly (GO:0010257)3.49131626
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49131626
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.48825896
42positive regulation of uterine smooth muscle contraction (GO:0070474)3.46959385
43piRNA metabolic process (GO:0034587)3.45594948
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38312031
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.34391738
46termination of RNA polymerase III transcription (GO:0006386)3.33895208
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.33895208
48regulation of regulatory T cell differentiation (GO:0045589)3.31586420
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27287993
50pseudouridine synthesis (GO:0001522)3.23815514
51mitochondrial respiratory chain complex assembly (GO:0033108)3.23076125
52quinone biosynthetic process (GO:1901663)3.21274509
53adenosine metabolic process (GO:0046085)3.20937382
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16436382
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15945072
56GPI anchor biosynthetic process (GO:0006506)3.13770147
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12982080
58positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.12968427
59positive regulation of cell killing (GO:0031343)3.03170097
60positive regulation of calcium-mediated signaling (GO:0050850)3.01848819
61positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01292406
62positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99525338
63viral mRNA export from host cell nucleus (GO:0046784)2.97341926
64nucleotide salvage (GO:0043173)2.95421421
65protein polyglutamylation (GO:0018095)2.95308204
66positive regulation of cell cycle arrest (GO:0071158)2.93062430
67regulation of cellular amine metabolic process (GO:0033238)2.89925950
68response to interferon-beta (GO:0035456)2.89889754
69electron transport chain (GO:0022900)2.88021062
70negative regulation of nitric oxide biosynthetic process (GO:0045019)2.87674484
71GPI anchor metabolic process (GO:0006505)2.87304495
72respiratory electron transport chain (GO:0022904)2.86517880
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86460910
74ATP synthesis coupled proton transport (GO:0015986)2.86460910
75positive regulation of natural killer cell mediated immunity (GO:0002717)2.85537646
76regulation of B cell differentiation (GO:0045577)2.84957670
77positive regulation of ligase activity (GO:0051351)2.84948548
78regulation of leukocyte mediated cytotoxicity (GO:0001910)2.83453537
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82535638
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82449731
81regulation of T cell mediated cytotoxicity (GO:0001914)2.77774882
82rRNA methylation (GO:0031167)2.76745052
83regulation of alpha-beta T cell proliferation (GO:0046640)2.76471610
84DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75883163
85regulation of mitochondrial translation (GO:0070129)2.75274708
86negative regulation of oxidoreductase activity (GO:0051354)2.74805609
87regulation of cell killing (GO:0031341)2.73196981
88organelle disassembly (GO:1903008)2.72684185
89cytolysis (GO:0019835)2.72571433
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72099857
91regulation of natural killer cell mediated immunity (GO:0002715)2.72099857
92regulation of defense response to virus by host (GO:0050691)2.70945990
93antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70504141
94regulation of uterine smooth muscle contraction (GO:0070472)2.69601606
95purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.69538452
96negative thymic T cell selection (GO:0045060)2.69301323
97nucleobase biosynthetic process (GO:0046112)2.67470519
98cellular response to interleukin-15 (GO:0071350)2.65737295
99DNA methylation involved in gamete generation (GO:0043046)2.65467093
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.64528236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.22466207
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.73604266
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42489884
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41644957
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.40990129
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.35038515
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.01337321
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.86573106
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84336841
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68019377
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65293718
12VDR_23849224_ChIP-Seq_CD4+_Human2.64659291
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52458867
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.50532809
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50177567
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48991450
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34741606
18FOXP3_21729870_ChIP-Seq_TREG_Human2.33804282
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.32263339
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21978771
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.12691156
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11998428
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.09607819
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07169499
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06830808
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97559277
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96752704
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90159969
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89139640
30VDR_22108803_ChIP-Seq_LS180_Human1.88698749
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.87831890
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81076286
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75215029
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74194526
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67576395
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67075093
37ZNF274_21170338_ChIP-Seq_K562_Hela1.64567116
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64456191
39ELK1_19687146_ChIP-ChIP_HELA_Human1.62845993
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62740260
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62263754
42MYB_26560356_Chip-Seq_TH2_Human1.61645221
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59996778
44CIITA_25753668_ChIP-Seq_RAJI_Human1.56999163
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55488374
46DCP1A_22483619_ChIP-Seq_HELA_Human1.54188435
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53603187
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51795039
49E2F7_22180533_ChIP-Seq_HELA_Human1.50749782
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47310543
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46117031
52GATA3_26560356_Chip-Seq_TH2_Human1.42265574
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41927547
54MYC_18940864_ChIP-ChIP_HL60_Human1.41081364
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40783419
56YY1_22570637_ChIP-Seq_MALME-3M_Human1.39669194
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38905840
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37782088
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36952629
60IRF1_19129219_ChIP-ChIP_H3396_Human1.30561382
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29470487
62XRN2_22483619_ChIP-Seq_HELA_Human1.28299918
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27101794
64GABP_19822575_ChIP-Seq_HepG2_Human1.23063803
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20574865
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19636072
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19182916
68GATA3_27048872_Chip-Seq_THYMUS_Human1.17506062
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16381532
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13924868
71TTF2_22483619_ChIP-Seq_HELA_Human1.12518827
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10114272
73KDM5A_27292631_Chip-Seq_BREAST_Human1.08752620
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04197959
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.03481163
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03420446
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00610948
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99894191
79IGF1R_20145208_ChIP-Seq_DFB_Human0.99152213
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99063209
81MYB_26560356_Chip-Seq_TH1_Human0.98819023
82HTT_18923047_ChIP-ChIP_STHdh_Human0.98697468
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98393577
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97074514
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96986624
86TP53_22573176_ChIP-Seq_HFKS_Human0.95794065
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94821054
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93273008
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91613761
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.89761718
91BCL6_27268052_Chip-Seq_Bcells_Human0.89410986
92NCOR_22424771_ChIP-Seq_293T_Human0.89284763
93P300_27268052_Chip-Seq_Bcells_Human0.88921106
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.87784211
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87784211
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87431506
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.87293738
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87198772
99AR_20517297_ChIP-Seq_VCAP_Human0.84818396
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84754316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.51896896
2MP0003806_abnormal_nucleotide_metabolis3.64292972
3MP0009785_altered_susceptibility_to2.99615306
4MP0001835_abnormal_antigen_presentation2.81141196
5MP0002254_reproductive_system_inflammat2.68056940
6MP0006292_abnormal_olfactory_placode2.61178933
7MP0009333_abnormal_splenocyte_physiolog2.53423837
8MP0005646_abnormal_pituitary_gland2.52583390
9MP0003693_abnormal_embryo_hatching2.51405569
10MP0002822_catalepsy2.32041065
11MP0005000_abnormal_immune_tolerance2.29186994
12MP0000685_abnormal_immune_system2.27362311
13MP0005389_reproductive_system_phenotype2.26105252
14MP0002160_abnormal_reproductive_system2.22483325
15MP0003763_abnormal_thymus_physiology2.15931290
16MP0004147_increased_porphyrin_level2.15023633
17MP0002138_abnormal_hepatobiliary_system2.12209298
18MP0002006_tumorigenesis2.11384137
19MP0000372_irregular_coat_pigmentation2.05945336
20MP0010155_abnormal_intestine_physiology2.04950202
21MP0002148_abnormal_hypersensitivity_rea2.02718263
22MP0002166_altered_tumor_susceptibility2.02353900
23MP0005025_abnormal_response_to1.97680332
24MP0001919_abnormal_reproductive_system1.94967562
25MP0001800_abnormal_humoral_immune1.88971930
26MP0003436_decreased_susceptibility_to1.88382329
27MP0009764_decreased_sensitivity_to1.81931432
28MP0002723_abnormal_immune_serum1.79780588
29MP0000678_abnormal_parathyroid_gland1.75414531
30MP0005083_abnormal_biliary_tract1.67337523
31MP0005645_abnormal_hypothalamus_physiol1.66576628
32MP0002420_abnormal_adaptive_immunity1.63101460
33MP0001819_abnormal_immune_cell1.58938862
34MP0002736_abnormal_nociception_after1.58415760
35MP0000703_abnormal_thymus_morphology1.56614037
36MP0003724_increased_susceptibility_to1.47102480
37MP0002452_abnormal_antigen_presenting1.47072691
38MP0003123_paternal_imprinting1.47043839
39MP0002132_abnormal_respiratory_system1.44825926
40MP0000716_abnormal_immune_system1.43806237
41MP0001790_abnormal_immune_system1.43653044
42MP0005387_immune_system_phenotype1.43653044
43MP0002398_abnormal_bone_marrow1.39612942
44MP0001873_stomach_inflammation1.39237685
45MP0008875_abnormal_xenobiotic_pharmacok1.31981781
46MP0001968_abnormal_touch/_nociception1.30501708
47MP0006082_CNS_inflammation1.30272896
48MP0008872_abnormal_physiological_respon1.28524644
49MP0002722_abnormal_immune_system1.28252000
50MP0006072_abnormal_retinal_apoptosis1.27824945
51MP0008469_abnormal_protein_level1.24725854
52MP0001845_abnormal_inflammatory_respons1.24362517
53MP0002405_respiratory_system_inflammati1.24058316
54MP0000689_abnormal_spleen_morphology1.23460436
55MP0000490_abnormal_crypts_of1.23017958
56MP0002429_abnormal_blood_cell1.21546426
57MP0002876_abnormal_thyroid_physiology1.20681392
58MP0002419_abnormal_innate_immunity1.18770704
59MP0003866_abnormal_defecation1.16465439
60MP0009765_abnormal_xenobiotic_induced1.15892119
61MP0005075_abnormal_melanosome_morpholog1.14375825
62MP0010094_abnormal_chromosome_stability1.10976165
63MP0001881_abnormal_mammary_gland1.10843135
64MP0003880_abnormal_central_pattern1.10400944
65MP0001501_abnormal_sleep_pattern1.09656307
66MP0009763_increased_sensitivity_to1.08671736
67MP0004947_skin_inflammation1.08071140
68MP0008058_abnormal_DNA_repair1.07107636
69MP0001905_abnormal_dopamine_level1.02884470
70MP0005410_abnormal_fertilization1.01669813
71MP0006035_abnormal_mitochondrial_morpho0.97076485
72MP0003011_delayed_dark_adaptation0.96039917
73MP0001533_abnormal_skeleton_physiology0.92040962
74MP0005084_abnormal_gallbladder_morpholo0.91935279
75MP0003718_maternal_effect0.91876831
76MP0003638_abnormal_response/metabolism_0.91213228
77MP0003787_abnormal_imprinting0.90353517
78MP0002102_abnormal_ear_morphology0.90306537
79MP0006036_abnormal_mitochondrial_physio0.89407682
80MP0001119_abnormal_female_reproductive0.88715554
81MP0004957_abnormal_blastocyst_morpholog0.88647121
82MP0008877_abnormal_DNA_methylation0.87167357
83MP0005451_abnormal_body_composition0.86358118
84MP0002019_abnormal_tumor_incidence0.86271689
85MP0003077_abnormal_cell_cycle0.84257226
86MP0001243_abnormal_dermal_layer0.79024595
87MP0005636_abnormal_mineral_homeostasis0.78809131
88MP0001529_abnormal_vocalization0.76311219
89MP0009697_abnormal_copulation0.75374747
90MP0009278_abnormal_bone_marrow0.75266540
91MP0000627_abnormal_mammary_gland0.74944204
92MP0003252_abnormal_bile_duct0.73092871
93MP0002277_abnormal_respiratory_mucosa0.73027434
94MP0008932_abnormal_embryonic_tissue0.71883977
95MP0004043_abnormal_pH_regulation0.71869064
96MP0000427_abnormal_hair_cycle0.71791496
97MP0003111_abnormal_nucleus_morphology0.71725698
98MP0005167_abnormal_blood-brain_barrier0.68698463
99MP0005085_abnormal_gallbladder_physiolo0.68353033
100MP0002933_joint_inflammation0.68315410

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.37219902
2Mitochondrial inheritance (HP:0001427)4.05356703
3Acute necrotizing encephalopathy (HP:0006965)4.01499257
4Severe combined immunodeficiency (HP:0004430)3.97408258
5T lymphocytopenia (HP:0005403)3.88241926
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.81752520
7IgG deficiency (HP:0004315)3.76368660
8Abnormal mitochondria in muscle tissue (HP:0008316)3.71579166
9Increased CSF lactate (HP:0002490)3.70787171
10Abnormality of T cell number (HP:0011839)3.54146887
11Hepatocellular necrosis (HP:0001404)3.52977633
12Progressive macrocephaly (HP:0004481)3.52971804
13Acute encephalopathy (HP:0006846)3.40554607
14Combined immunodeficiency (HP:0005387)3.39858923
15Prostate neoplasm (HP:0100787)3.37356304
16Increased hepatocellular lipid droplets (HP:0006565)3.36640079
17Hepatic necrosis (HP:0002605)3.19837406
18Renal Fanconi syndrome (HP:0001994)3.15222349
19Abnormality of T cells (HP:0002843)3.12712235
20Abnormality of the prostate (HP:0008775)3.09457401
21Increased intramyocellular lipid droplets (HP:0012240)3.01092290
22Lipid accumulation in hepatocytes (HP:0006561)3.00938040
23Testicular atrophy (HP:0000029)2.98086452
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89674629
25Hypoplasia of the uterus (HP:0000013)2.82513737
26Pancreatic cysts (HP:0001737)2.73605199
27Attenuation of retinal blood vessels (HP:0007843)2.67885228
28Thyroiditis (HP:0100646)2.65340617
29Increased serum lactate (HP:0002151)2.64113988
30Abnormality of B cell number (HP:0010975)2.63883487
31Hypoplasia of the pons (HP:0012110)2.63818852
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59771223
33Aplasia/hypoplasia of the uterus (HP:0008684)2.51334441
34Abnormality of the pons (HP:0007361)2.46883828
35Concave nail (HP:0001598)2.45788376
36Pendular nystagmus (HP:0012043)2.44660688
37Cerebral edema (HP:0002181)2.44483226
38B lymphocytopenia (HP:0010976)2.43485071
39Type II lissencephaly (HP:0007260)2.42080445
40Autoimmune thrombocytopenia (HP:0001973)2.41431631
41Panhypogammaglobulinemia (HP:0003139)2.41101672
42Increased muscle lipid content (HP:0009058)2.38326178
43Abolished electroretinogram (ERG) (HP:0000550)2.35503275
44Pancreatic fibrosis (HP:0100732)2.34789909
45Absent thumb (HP:0009777)2.34283783
46Hypoproteinemia (HP:0003075)2.30439116
47Autoimmune hemolytic anemia (HP:0001890)2.30436227
48Lactic acidosis (HP:0003128)2.27780623
49Increased corneal curvature (HP:0100692)2.27466515
50Keratoconus (HP:0000563)2.27466515
51Oral leukoplakia (HP:0002745)2.27154916
52Abnormality of T cell physiology (HP:0011840)2.20738092
53Optic disc pallor (HP:0000543)2.20194258
54Pancytopenia (HP:0001876)2.19747269
55Abnormal rod and cone electroretinograms (HP:0008323)2.16674552
563-Methylglutaconic aciduria (HP:0003535)2.13654180
57Exertional dyspnea (HP:0002875)2.12389492
58Gastrointestinal infarctions (HP:0005244)2.10745878
59Aplastic anemia (HP:0001915)2.10725328
60True hermaphroditism (HP:0010459)2.10396105
61Chronic diarrhea (HP:0002028)2.09037248
62Increased serum ferritin (HP:0003281)2.06290141
63Meckel diverticulum (HP:0002245)2.04772162
64Respiratory failure (HP:0002878)2.04649383
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.03987733
66Hypoalbuminemia (HP:0003073)2.03867181
67Abnormal albumin level (HP:0012116)2.03867181
68Rough bone trabeculation (HP:0100670)2.02404166
69Conical tooth (HP:0000698)2.00547626
70Abnormality of eosinophils (HP:0001879)1.97287906
71Respiratory difficulties (HP:0002880)1.97075349
72Squamous cell carcinoma (HP:0002860)1.96178279
73Abnormality of the renal cortex (HP:0011035)1.95771021
74Cutaneous melanoma (HP:0012056)1.95329477
75Stomatitis (HP:0010280)1.94882907
76Recurrent viral infections (HP:0004429)1.94771035
77Abnormality of the ileum (HP:0001549)1.92464031
78Decreased central vision (HP:0007663)1.91012077
79Clubbing of toes (HP:0100760)1.90531646
80Abnormality of transition element cation homeostasis (HP:0011030)1.90029041
81Abnormality of the preputium (HP:0100587)1.89457619
82Exercise intolerance (HP:0003546)1.86284832
83Encephalitis (HP:0002383)1.83605316
84Abnormality of male internal genitalia (HP:0000022)1.81429631
85Anorexia (HP:0002039)1.81267098
86Abnormal drinking behavior (HP:0030082)1.81008132
87Polydipsia (HP:0001959)1.81008132
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79262751
89Lymphoma (HP:0002665)1.79218830
90Type I transferrin isoform profile (HP:0003642)1.78237103
91Premature graying of hair (HP:0002216)1.75731570
92Small hand (HP:0200055)1.74940424
93Abnormality of urine glucose concentration (HP:0011016)1.74320725
94Glycosuria (HP:0003076)1.74320725
95Chronic mucocutaneous candidiasis (HP:0002728)1.73753687
96Recurrent cutaneous fungal infections (HP:0011370)1.73753687
97Bile duct proliferation (HP:0001408)1.73622174
98Abnormal biliary tract physiology (HP:0012439)1.73622174
99IgM deficiency (HP:0002850)1.72971076
100Increased serum pyruvate (HP:0003542)1.69779630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.45737111
2TLK15.78686919
3TESK24.91415283
4KDR3.19408807
5VRK13.04125169
6VRK22.92131563
7SCYL22.68857565
8ADRBK22.16669192
9EIF2AK32.13983454
10TAOK31.80404654
11TXK1.79556152
12MAPKAPK31.79226777
13TESK11.74418609
14ITK1.72686953
15TEC1.58752951
16MAP4K21.48748984
17GRK11.47525663
18FRK1.44259933
19SRPK11.39294222
20LIMK11.38864193
21RPS6KA41.35843910
22TIE11.33779959
23MAP3K91.20621259
24EIF2AK21.18680360
25BRSK21.18530972
26KIT1.17010402
27EIF2AK11.14348904
28CSF1R1.13402503
29RPS6KA51.13012468
30NEK11.11937470
31PLK41.07800811
32WNK41.07517615
33FES1.07372958
34NUAK11.06305012
35PIM21.03374048
36TNK20.94364898
37MST40.91454178
38CSNK1G30.89933887
39GRK60.88134034
40AURKA0.86489540
41STK160.85350152
42MAP4K10.83774682
43PLK10.81890767
44ERBB30.80871172
45CAMKK20.79396683
46DAPK10.78379906
47CSNK1G10.77273998
48TAF10.77004510
49IKBKB0.74585625
50TRIM280.73445320
51PIM10.73377054
52BRSK10.70676022
53PDK20.68701884
54TBK10.68573803
55CDC70.68012944
56SYK0.65132660
57GRK50.64530974
58CDK70.64378175
59BMPR1B0.63297006
60CSNK1A1L0.58835357
61PRKCQ0.58599619
62PLK30.57629955
63BTK0.56611872
64MAP2K70.54913908
65CHEK20.54866966
66TSSK60.53756381
67DAPK30.52956655
68BCKDK0.52132713
69NME20.50600451
70CSNK1G20.48228429
71AURKB0.47772635
72LCK0.47573686
73LYN0.47134262
74ATR0.46531852
75SIK10.45918329
76FLT30.45558950
77INSRR0.45026938
78ADRBK10.43837118
79GRK70.43010690
80IKBKE0.39669197
81CHUK0.38389841
82PKN10.38067254
83PIK3CA0.33265820
84MAPKAPK50.32312102
85JAK30.32061831
86WEE10.30739491
87CSNK1D0.30728814
88CSNK2A10.30448046
89MAPK110.29677387
90BUB10.29388592
91OXSR10.28646755
92MAP3K140.28620650
93ZAP700.27467422
94CSNK1A10.27221257
95ROCK10.27152933
96PASK0.26061909
97AKT20.24002450
98NME10.23775154
99ABL20.23325825
100IGF1R0.21969320

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.13893337
2Primary immunodeficiency_Homo sapiens_hsa053403.79265472
3Systemic lupus erythematosus_Homo sapiens_hsa053223.28272219
4Antigen processing and presentation_Homo sapiens_hsa046122.64086193
5Oxidative phosphorylation_Homo sapiens_hsa001902.61098909
6RNA polymerase_Homo sapiens_hsa030202.56480111
7Asthma_Homo sapiens_hsa053102.50320458
8Parkinsons disease_Homo sapiens_hsa050122.47819400
9Allograft rejection_Homo sapiens_hsa053302.37065104
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34622033
11Ribosome_Homo sapiens_hsa030102.31620257
12Graft-versus-host disease_Homo sapiens_hsa053322.24332726
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23910211
14Autoimmune thyroid disease_Homo sapiens_hsa053202.20617481
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.08851496
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05241221
17DNA replication_Homo sapiens_hsa030301.95302406
18Homologous recombination_Homo sapiens_hsa034401.94397889
19Type I diabetes mellitus_Homo sapiens_hsa049401.93544909
20Hematopoietic cell lineage_Homo sapiens_hsa046401.77402500
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71996925
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71344238
23Alcoholism_Homo sapiens_hsa050341.67302396
24Sulfur metabolism_Homo sapiens_hsa009201.60454265
25Alzheimers disease_Homo sapiens_hsa050101.53591030
26Pyrimidine metabolism_Homo sapiens_hsa002401.49747958
27Sulfur relay system_Homo sapiens_hsa041221.47500495
28Huntingtons disease_Homo sapiens_hsa050161.42437469
29Fanconi anemia pathway_Homo sapiens_hsa034601.37893037
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36026238
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33211776
32Spliceosome_Homo sapiens_hsa030401.28383260
33Mismatch repair_Homo sapiens_hsa034301.23633302
34Base excision repair_Homo sapiens_hsa034101.20009150
35Butanoate metabolism_Homo sapiens_hsa006501.19327279
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05439512
37Purine metabolism_Homo sapiens_hsa002301.02540795
38Protein export_Homo sapiens_hsa030601.00555621
39Basal transcription factors_Homo sapiens_hsa030220.98757218
40RNA degradation_Homo sapiens_hsa030180.96967408
41Selenocompound metabolism_Homo sapiens_hsa004500.94551144
42Linoleic acid metabolism_Homo sapiens_hsa005910.92264217
43One carbon pool by folate_Homo sapiens_hsa006700.92180752
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.92162175
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91903629
46Herpes simplex infection_Homo sapiens_hsa051680.91692031
47Viral myocarditis_Homo sapiens_hsa054160.91612302
48Rheumatoid arthritis_Homo sapiens_hsa053230.90622199
49Viral carcinogenesis_Homo sapiens_hsa052030.85731825
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82860806
51RNA transport_Homo sapiens_hsa030130.81625346
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78926557
53T cell receptor signaling pathway_Homo sapiens_hsa046600.78868434
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78395781
55Epstein-Barr virus infection_Homo sapiens_hsa051690.74507547
56Nucleotide excision repair_Homo sapiens_hsa034200.73370275
57Nitrogen metabolism_Homo sapiens_hsa009100.71764982
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.70931310
59Cardiac muscle contraction_Homo sapiens_hsa042600.69939596
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68066006
61Phototransduction_Homo sapiens_hsa047440.67960103
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66217747
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64836731
64Fat digestion and absorption_Homo sapiens_hsa049750.59511324
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59379917
66Measles_Homo sapiens_hsa051620.57817651
67Apoptosis_Homo sapiens_hsa042100.55847720
68Fatty acid elongation_Homo sapiens_hsa000620.55711940
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.50859814
70Non-homologous end-joining_Homo sapiens_hsa034500.49067887
71Peroxisome_Homo sapiens_hsa041460.48353222
72Regulation of autophagy_Homo sapiens_hsa041400.47090648
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46808564
74Staphylococcus aureus infection_Homo sapiens_hsa051500.46247533
75Metabolic pathways_Homo sapiens_hsa011000.44904264
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44017779
77p53 signaling pathway_Homo sapiens_hsa041150.43631463
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43600699
79Legionellosis_Homo sapiens_hsa051340.40957925
80Ether lipid metabolism_Homo sapiens_hsa005650.40050565
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.39144623
82Arachidonic acid metabolism_Homo sapiens_hsa005900.37409168
83Tryptophan metabolism_Homo sapiens_hsa003800.35980877
84Leishmaniasis_Homo sapiens_hsa051400.33850725
85HTLV-I infection_Homo sapiens_hsa051660.33467975
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32880205
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30586549
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25533874
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25446664
90Malaria_Homo sapiens_hsa051440.24099511
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23073938
92Caffeine metabolism_Homo sapiens_hsa002320.23013671
93Chemical carcinogenesis_Homo sapiens_hsa052040.22883572
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22336051
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.20035706
96Retinol metabolism_Homo sapiens_hsa008300.20003169
97Shigellosis_Homo sapiens_hsa051310.19365893
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18599400
99Pentose phosphate pathway_Homo sapiens_hsa000300.17271984
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17100503

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »