ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.08391989
2	inositol phosphate catabolic process (GO:0071545)	4.84567442
3	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.82954347
4	inositol phosphate dephosphorylation (GO:0046855)	4.82954347
5	protein-cofactor linkage (GO:0018065)	4.55146719
6	sleep (GO:0030431)	4.49768286
7	ubiquinone biosynthetic process (GO:0006744)	4.42400468
8	magnesium ion transport (GO:0015693)	4.34940127
9	mitotic cell cycle arrest (GO:0071850)	4.23092145
10	ubiquinone metabolic process (GO:0006743)	4.12571664
11	endoderm formation (GO:0001706)	4.05690206
12	organelle disassembly (GO:1903008)	4.02508801
13	positive regulation of glycolytic process (GO:0045821)	3.98129290
14	negative regulation of thymocyte apoptotic process (GO:0070244)	3.87959377
15	DNA methylation involved in gamete generation (GO:0043046)	3.83255772
16	behavioral response to ethanol (GO:0048149)	3.77420664
17	rRNA modification (GO:0000154)	3.76143804
18	polyol catabolic process (GO:0046174)	3.75150781
19	maturation of 5.8S rRNA (GO:0000460)	3.68840051
20	quinone biosynthetic process (GO:1901663)	3.68374520
21	piRNA metabolic process (GO:0034587)	3.55579485
22	peptidyl-threonine dephosphorylation (GO:0035970)	3.51686945
23	negative regulation of T cell apoptotic process (GO:0070233)	3.44037200
24	parturition (GO:0007567)	3.36192556
25	N-glycan processing (GO:0006491)	3.33975283
26	response to pheromone (GO:0019236)	3.31714583
27	response to muramyl dipeptide (GO:0032495)	3.31372332
28	regulation of oxidative stress-induced neuron death (GO:1903203)	3.31226292
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.25555672
30	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.22972611
31	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.20724137
32	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.20724137
33	aspartate family amino acid catabolic process (GO:0009068)	3.20214891
34	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.17650987
35	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.15426932
36	L-fucose catabolic process (GO:0042355)	3.15353380
37	fucose catabolic process (GO:0019317)	3.15353380
38	L-fucose metabolic process (GO:0042354)	3.15353380
39	tryptophan metabolic process (GO:0006568)	3.15104414
40	regulation of T-helper 1 cell differentiation (GO:0045625)	3.07958614
41	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.06638840
42	GPI anchor metabolic process (GO:0006505)	3.03686029
43	mannosylation (GO:0097502)	3.00121587
44	negative regulation of meiotic cell cycle (GO:0051447)	2.99434235
45	negative regulation of telomere maintenance (GO:0032205)	2.98735662
46	negative regulation of membrane potential (GO:0045837)	2.97720440
47	kynurenine metabolic process (GO:0070189)	2.97179821
48	peptidyl-arginine omega-N-methylation (GO:0035247)	2.88085186
49	protein polyglutamylation (GO:0018095)	2.87863779
50	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.86289946
51	positive regulation of mast cell degranulation (GO:0043306)	2.86289946
52	GPI anchor biosynthetic process (GO:0006506)	2.85955942
53	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.85708773
54	negative regulation of T-helper cell differentiation (GO:0045623)	2.83226446
55	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.83226446
56	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.80220088
57	negative regulation of mast cell activation (GO:0033004)	2.77861291
58	regulation of relaxation of muscle (GO:1901077)	2.77207330
59	positive regulation of prostaglandin secretion (GO:0032308)	2.75769845
60	tRNA modification (GO:0006400)	2.75076613
61	positive regulation of receptor biosynthetic process (GO:0010870)	2.72766779
62	ribonucleoprotein complex disassembly (GO:0032988)	2.71676259
63	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.71432289
64	negative regulation of astrocyte differentiation (GO:0048712)	2.70918964
65	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.70093170
66	regulation of mitotic spindle checkpoint (GO:1903504)	2.70093170
67	cAMP catabolic process (GO:0006198)	2.68813928
68	adenosine metabolic process (GO:0046085)	2.63690860
69	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.63681983
70	sulfation (GO:0051923)	2.60522046
71	pyrimidine nucleobase catabolic process (GO:0006208)	2.60257847
72	indolalkylamine metabolic process (GO:0006586)	2.59398719
73	cullin deneddylation (GO:0010388)	2.59009657
74	opioid receptor signaling pathway (GO:0038003)	2.58311255
75	protein neddylation (GO:0045116)	2.58253365
76	peptidyl-arginine methylation (GO:0018216)	2.58018235
77	peptidyl-arginine N-methylation (GO:0035246)	2.58018235
78	primary amino compound metabolic process (GO:1901160)	2.57684579
79	regulation of thymocyte apoptotic process (GO:0070243)	2.56635555
80	positive regulation of antigen processing and presentation (GO:0002579)	2.56077552
81	protein deneddylation (GO:0000338)	2.55238955
82	cytidine metabolic process (GO:0046087)	2.55032770
83	cytidine catabolic process (GO:0006216)	2.55032770
84	cytidine deamination (GO:0009972)	2.55032770
85	urinary tract smooth muscle contraction (GO:0014848)	2.54093047
86	regulation of regulatory T cell differentiation (GO:0045589)	2.53634537
87	nucleotide transmembrane transport (GO:1901679)	2.53495545
88	indole-containing compound metabolic process (GO:0042430)	2.53209971
89	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	2.53148246
90	behavioral response to nicotine (GO:0035095)	2.51993210
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.50998159
92	positive regulation of mast cell activation (GO:0033005)	2.50863194
93	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.44982596
94	quinone metabolic process (GO:1901661)	2.44617108
95	base-excision repair, AP site formation (GO:0006285)	2.43969647
96	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.43800311
97	neuronal action potential (GO:0019228)	2.41878147
98	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.41801714
99	negative regulation of cell killing (GO:0031342)	2.41801714
100	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.41107946

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	6.03090472
2	VDR_22108803_ChIP-Seq_LS180_Human	4.61375805
3	ZNF274_21170338_ChIP-Seq_K562_Hela	4.13777359
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.86355832
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.78928010
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.76083455
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.65961484
8	FUS_26573619_Chip-Seq_HEK293_Human	2.62550509
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60301770
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.39678841
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.38532596
12	GATA1_22025678_ChIP-Seq_K562_Human	2.34511899
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.31778954
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.26031597
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.15495723
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06002110
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.05182503
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03343764
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.97115706
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.83495422
21	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68626281
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68493282
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67756062
24	EWS_26573619_Chip-Seq_HEK293_Human	1.67363102
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.66269609
26	P300_19829295_ChIP-Seq_ESCs_Human	1.62528566
27	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.59931616
28	GATA3_26560356_Chip-Seq_TH2_Human	1.58983674
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55299611
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53646014
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.53646014
32	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53252900
33	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.51992342
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51720815
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51584332
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47043876
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46025238
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45832848
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.43540663
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41903563
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.38995563
42	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.38560707
43	AR_20517297_ChIP-Seq_VCAP_Human	1.36777808
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35233168
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32001718
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30183776
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30145933
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29765262
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29765262
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28922615
51	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.26369923
52	AR_25329375_ChIP-Seq_VCAP_Human	1.23953325
53	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23717225
54	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.23481919
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22390233
56	TAF15_26573619_Chip-Seq_HEK293_Human	1.21536299
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17686091
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17040716
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17040716
60	TP53_16413492_ChIP-PET_HCT116_Human	1.16895720
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13977858
62	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13865171
63	STAT3_23295773_ChIP-Seq_U87_Human	1.12057114
64	TCF4_23295773_ChIP-Seq_U87_Human	1.11051959
65	RXR_22108803_ChIP-Seq_LS180_Human	1.11048839
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10157287
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09698052
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09059363
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07710059
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.07212387
71	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.06784613
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06187889
73	ERG_20517297_ChIP-Seq_VCAP_Human	1.05515561
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05156946
75	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.02743558
76	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.02622358
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.01102815
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.00923488
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00230017
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99943428
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99943428
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99294391
83	MYB_26560356_Chip-Seq_TH2_Human	0.98235325
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96867400
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96553751
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96480051
87	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95397557
88	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.95153478
89	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.94725675
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.94138778
91	NCOR_22424771_ChIP-Seq_293T_Human	0.94030352
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93417733
93	AR_21572438_ChIP-Seq_LNCaP_Human	0.93384217
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93174414
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.92953357
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91812432
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89844259
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.89083487
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88483905
100	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88383676

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	6.46620954
2	MP0003724_increased_susceptibility_to	4.22410041
3	MP0006054_spinal_hemorrhage	2.94440265
4	MP0006072_abnormal_retinal_apoptosis	2.81419921
5	MP0003806_abnormal_nucleotide_metabolis	2.42570100
6	MP0002138_abnormal_hepatobiliary_system	2.40494265
7	MP0009046_muscle_twitch	2.33077681
8	MP0008872_abnormal_physiological_respon	2.28507612
9	MP0003252_abnormal_bile_duct	2.21317059
10	MP0009764_decreased_sensitivity_to	2.19472786
11	MP0003195_calcinosis	2.14825632
12	MP0001501_abnormal_sleep_pattern	2.13724721
13	MP0008877_abnormal_DNA_methylation	1.98109951
14	MP0005646_abnormal_pituitary_gland	1.87734443
15	MP0002163_abnormal_gland_morphology	1.80828301
16	MP0004043_abnormal_pH_regulation	1.80509194
17	MP0005085_abnormal_gallbladder_physiolo	1.79560156
18	MP0002272_abnormal_nervous_system	1.77658615
19	MP0004147_increased_porphyrin_level	1.76967905
20	MP0002876_abnormal_thyroid_physiology	1.71694514
21	MP0001968_abnormal_touch/_nociception	1.67639703
22	MP0001986_abnormal_taste_sensitivity	1.64986344
23	MP0002332_abnormal_exercise_endurance	1.53676663
24	MP0005167_abnormal_blood-brain_barrier	1.53429495
25	MP0003656_abnormal_erythrocyte_physiolo	1.52984931
26	MP0000427_abnormal_hair_cycle	1.51550181
27	MP0002148_abnormal_hypersensitivity_rea	1.46746296
28	MP0005551_abnormal_eye_electrophysiolog	1.45141640
29	MP0004215_abnormal_myocardial_fiber	1.43792647
30	MP0001800_abnormal_humoral_immune	1.42621282
31	MP0005000_abnormal_immune_tolerance	1.42355694
32	MP0006292_abnormal_olfactory_placode	1.37009683
33	MP0005084_abnormal_gallbladder_morpholo	1.32759109
34	MP0009785_altered_susceptibility_to	1.31257245
35	MP0005386_behavior/neurological_phenoty	1.30321621
36	MP0004924_abnormal_behavior	1.30321621
37	MP0001502_abnormal_circadian_rhythm	1.28302345
38	MP0000230_abnormal_systemic_arterial	1.28146986
39	MP0002723_abnormal_immune_serum	1.27744266
40	MP0004885_abnormal_endolymph	1.27357586
41	MP0003718_maternal_effect	1.27147426
42	MP0002139_abnormal_hepatobiliary_system	1.26534988
43	MP0005671_abnormal_response_to	1.25403319
44	MP0009745_abnormal_behavioral_response	1.23575124
45	MP0002736_abnormal_nociception_after	1.23249595
46	MP0005253_abnormal_eye_physiology	1.21471498
47	MP0002452_abnormal_antigen_presenting	1.20541697
48	MP0003828_pulmonary_edema	1.20475346
49	MP0002572_abnormal_emotion/affect_behav	1.20011600
50	MP0002928_abnormal_bile_duct	1.19960356
51	MP0008775_abnormal_heart_ventricle	1.17690037
52	MP0008875_abnormal_xenobiotic_pharmacok	1.14890388
53	MP0002254_reproductive_system_inflammat	1.14386603
54	MP0002282_abnormal_trachea_morphology	1.13672620
55	MP0004084_abnormal_cardiac_muscle	1.12581893
56	MP0002735_abnormal_chemical_nociception	1.11306663
57	MP0000685_abnormal_immune_system	1.10823061
58	MP0003638_abnormal_response/metabolism_	1.08399890
59	MP0004782_abnormal_surfactant_physiolog	1.08242151
60	MP0002277_abnormal_respiratory_mucosa	1.06522516
61	MP0006082_CNS_inflammation	1.05324261
62	MP0002419_abnormal_innate_immunity	1.04056596
63	MP0004142_abnormal_muscle_tone	1.04020779
64	MP0001835_abnormal_antigen_presentation	1.04020510
65	MP0002420_abnormal_adaptive_immunity	1.03422278
66	MP0003436_decreased_susceptibility_to	1.03027467
67	MP0001764_abnormal_homeostasis	1.01474448
68	MP0002733_abnormal_thermal_nociception	1.00482642
69	MP0004484_altered_response_of	1.00199657
70	MP0001819_abnormal_immune_cell	1.00054385
71	MP0009763_increased_sensitivity_to	0.99350498
72	MP0005266_abnormal_metabolism	0.94772698
73	MP0001970_abnormal_pain_threshold	0.93505445
74	MP0003075_altered_response_to	0.89231290
75	MP0001533_abnormal_skeleton_physiology	0.89055795
76	MP0005165_increased_susceptibility_to	0.88978469
77	MP0002166_altered_tumor_susceptibility	0.87892565
78	MP0002837_dystrophic_cardiac_calcinosis	0.87837442
79	MP0001486_abnormal_startle_reflex	0.86921268
80	MP0001984_abnormal_olfaction	0.85956819
81	MP0002234_abnormal_pharynx_morphology	0.85764136
82	MP0004145_abnormal_muscle_electrophysio	0.84714031
83	MP0006276_abnormal_autonomic_nervous	0.84503937
84	MP0005083_abnormal_biliary_tract	0.84348792
85	MP0005645_abnormal_hypothalamus_physiol	0.82479191
86	MP0001905_abnormal_dopamine_level	0.82398854
87	MP0005410_abnormal_fertilization	0.82358534
88	MP0002006_tumorigenesis	0.79724907
89	MP0002063_abnormal_learning/memory/cond	0.78951799
90	MP0005379_endocrine/exocrine_gland_phen	0.77187072
91	MP0001919_abnormal_reproductive_system	0.76839263
92	MP0003763_abnormal_thymus_physiology	0.76651952
93	MP0000716_abnormal_immune_system	0.76418796
94	MP0000689_abnormal_spleen_morphology	0.74626977
95	MP0003880_abnormal_central_pattern	0.73466686
96	MP0002102_abnormal_ear_morphology	0.71708802
97	MP0008469_abnormal_protein_level	0.69974690
98	MP0005319_abnormal_enzyme/_coenzyme	0.69936222
99	MP0009278_abnormal_bone_marrow	0.69583441
100	MP0003567_abnormal_fetal_cardiomyocyte	0.68819829

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dyschromatopsia (HP:0007641)	5.51272922
2	Abnormality of glycolipid metabolism (HP:0010969)	4.31520347
3	Abnormality of liposaccharide metabolism (HP:0010968)	4.31520347
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.31520347
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.21858306
6	Focal motor seizures (HP:0011153)	3.85329834
7	Abolished electroretinogram (ERG) (HP:0000550)	3.72763780
8	Flat capital femoral epiphysis (HP:0003370)	3.63130615
9	Stomach cancer (HP:0012126)	3.46381100
10	Carpal bone hypoplasia (HP:0001498)	3.29736366
11	Attenuation of retinal blood vessels (HP:0007843)	3.23245077
12	Central scotoma (HP:0000603)	3.21499453
13	Abnormal rod and cone electroretinograms (HP:0008323)	2.99071640
14	Visual hallucinations (HP:0002367)	2.99047752
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90961396
16	Abnormality of alanine metabolism (HP:0010916)	2.90961396
17	Hyperalaninemia (HP:0003348)	2.90961396
18	Concave nail (HP:0001598)	2.75729342
19	Keratoconus (HP:0000563)	2.72981290
20	Increased corneal curvature (HP:0100692)	2.72981290
21	Colon cancer (HP:0003003)	2.65303311
22	Type II lissencephaly (HP:0007260)	2.57326535
23	Abnormality of T cell number (HP:0011839)	2.51512407
24	Methylmalonic acidemia (HP:0002912)	2.50832909
25	Large eyes (HP:0001090)	2.49866608
26	Abnormality of the renal cortex (HP:0011035)	2.49382743
27	Dysostosis multiplex (HP:0000943)	2.49281269
28	Tongue fasciculations (HP:0001308)	2.48685398
29	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.46094411
30	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.44468092
31	Thyroid-stimulating hormone excess (HP:0002925)	2.42019572
32	Abnormality of the prostate (HP:0008775)	2.41945225
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38236652
34	Absent/shortened dynein arms (HP:0200106)	2.38236652
35	Abnormality of B cell number (HP:0010975)	2.32082924
36	Severe muscular hypotonia (HP:0006829)	2.31532749
37	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.30720676
38	Molar tooth sign on MRI (HP:0002419)	2.30257360
39	Abnormality of midbrain morphology (HP:0002418)	2.30257360
40	Generalized myoclonic seizures (HP:0002123)	2.23327405
41	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.22815071
42	Muscle fibrillation (HP:0010546)	2.18780388
43	IgG deficiency (HP:0004315)	2.16795422
44	Hemiplegia (HP:0002301)	2.15959941
45	Pancreatic cysts (HP:0001737)	2.13646977
46	Autoimmune hemolytic anemia (HP:0001890)	2.13236422
47	Clumsiness (HP:0002312)	2.11981129
48	Abnormality of T cells (HP:0002843)	2.10785071
49	3-Methylglutaconic aciduria (HP:0003535)	2.10369877
50	Chorioretinal atrophy (HP:0000533)	2.09371157
51	Flared iliac wings (HP:0002869)	2.08815194
52	Acute encephalopathy (HP:0006846)	2.08743705
53	Chronic mucocutaneous candidiasis (HP:0002728)	2.08728318
54	Recurrent cutaneous fungal infections (HP:0011370)	2.08728318
55	T lymphocytopenia (HP:0005403)	2.08069943
56	Elevated erythrocyte sedimentation rate (HP:0003565)	2.07859909
57	Opisthotonus (HP:0002179)	2.02598971
58	Methylmalonic aciduria (HP:0012120)	2.01730423
59	Progressive cerebellar ataxia (HP:0002073)	2.01580693
60	Hypoplasia of the uterus (HP:0000013)	2.00396308
61	Pachygyria (HP:0001302)	1.98903664
62	Congenital stationary night blindness (HP:0007642)	1.98397922
63	Long nose (HP:0003189)	1.95428213
64	Chronic diarrhea (HP:0002028)	1.95124431
65	Abnormality of the renal medulla (HP:0100957)	1.95039745
66	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.94014661
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.94014661
68	Abnormal protein glycosylation (HP:0012346)	1.94014661
69	Abnormal glycosylation (HP:0012345)	1.94014661
70	Recurrent bronchitis (HP:0002837)	1.93087142
71	Nephronophthisis (HP:0000090)	1.92525688
72	Abnormality of the femoral head (HP:0003368)	1.90863859
73	Parakeratosis (HP:0001036)	1.90170718
74	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.89489557
75	Scotoma (HP:0000575)	1.89479770
76	Prostate neoplasm (HP:0100787)	1.89061141
77	Conical tooth (HP:0000698)	1.87852942
78	Increased serum lactate (HP:0002151)	1.86296122
79	Decreased circulating renin level (HP:0003351)	1.84651659
80	Increased cerebral lipofuscin (HP:0011813)	1.84429485
81	Broad alveolar ridges (HP:0000187)	1.84136884
82	Pendular nystagmus (HP:0012043)	1.83719827
83	Delayed CNS myelination (HP:0002188)	1.80779148
84	Abnormality of the costochondral junction (HP:0000919)	1.80337989
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79762350
86	Abnormality of T cell physiology (HP:0011840)	1.79471079
87	Congenital, generalized hypertrichosis (HP:0004540)	1.77420587
88	Deformed sella turcica (HP:0002681)	1.76666541
89	Agitation (HP:0000713)	1.75660839
90	Decreased central vision (HP:0007663)	1.75095001
91	Metabolic alkalosis (HP:0200114)	1.74957785
92	Abnormal drinking behavior (HP:0030082)	1.74880448
93	Polydipsia (HP:0001959)	1.74880448
94	Optic neuritis (HP:0100653)	1.71643684
95	Retrobulbar optic neuritis (HP:0100654)	1.71643684
96	Constricted visual fields (HP:0001133)	1.71152634
97	Encephalitis (HP:0002383)	1.69054463
98	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.67515858
99	Hypothermia (HP:0002045)	1.67382622
100	Absence seizures (HP:0002121)	1.66973081

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	3.40204222
2	TLK1	3.16548443
3	MAP3K14	2.89052682
4	EIF2AK3	2.78263654
5	FRK	2.77326232
6	MAP4K2	2.69038156
7	TAOK3	2.65812468
8	TIE1	2.61599031
9	EIF2AK2	2.48965756
10	MAP2K2	2.46891947
11	CAMKK2	2.46072746
12	TXK	2.44844425
13	NTRK3	2.32621383
14	GRK7	2.30402369
15	BMPR1B	2.26078720
16	BRSK2	2.24449511
17	BCR	2.18170067
18	SCYL2	1.89665867
19	MAPK13	1.73224237
20	OXSR1	1.72898083
21	TEC	1.61745049
22	GRK1	1.57173561
23	ADRBK2	1.55818570
24	MAP2K6	1.51556757
25	ZAK	1.48208705
26	IRAK4	1.46754211
27	GRK6	1.44862680
28	IKBKE	1.44186771
29	CDK19	1.41377646
30	TNIK	1.29150734
31	PHKG2	1.25270853
32	PHKG1	1.25270853
33	TBK1	1.22774894
34	CAMKK1	1.22213556
35	MAP3K6	1.20721786
36	TAF1	1.20565794
37	ADRBK1	1.16701922
38	CSNK1G3	1.15793915
39	NEK6	1.15511712
40	CSNK1A1L	1.14532098
41	ITK	1.13012021
42	KIT	1.09623375
43	IKBKB	1.09425365
44	NUAK1	1.09232104
45	CSNK1G2	1.00771620
46	CSF1R	0.94738668
47	GRK5	0.92057994
48	TGFBR1	0.89654003
49	TESK2	0.84791448
50	PTK2B	0.83436618
51	ACVR1B	0.78378993
52	CSNK1G1	0.78335525
53	SYK	0.78188475
54	PDK2	0.77711443
55	PINK1	0.75724895
56	ERBB3	0.74953013
57	FGR	0.74405538
58	FES	0.73336776
59	WNK4	0.73238133
60	CASK	0.72249701
61	MARK1	0.68420283
62	STK38L	0.68080402
63	MAP2K1	0.67469980
64	CHUK	0.63724280
65	MAP4K1	0.63429597
66	RPS6KA4	0.62089834
67	MAPKAPK3	0.61041764
68	LCK	0.59810999
69	PLK3	0.58988484
70	MAP2K3	0.56560007
71	JAK3	0.56492289
72	STK11	0.56336233
73	FLT3	0.56028420
74	EIF2AK1	0.55300240
75	DYRK2	0.53977054
76	TNK2	0.48646615
77	IRAK1	0.47731181
78	BRSK1	0.44143635
79	PRKCQ	0.43230738
80	EPHA3	0.43227251
81	PLK2	0.42021218
82	ZAP70	0.40660057
83	PAK6	0.40550711
84	BMX	0.39637272
85	LIMK1	0.39117874
86	MATK	0.36238703
87	BTK	0.35845910
88	WNK3	0.35595965
89	PRKACB	0.34344490
90	LYN	0.34248003
91	IGF1R	0.33003553
92	PRKCI	0.30716038
93	VRK1	0.30417092
94	MAP2K4	0.29857951
95	BCKDK	0.29818308
96	PRKCE	0.29687635
97	TGFBR2	0.29525625
98	CSNK1D	0.29205094
99	EGFR	0.25994414
100	CDK8	0.25737350

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.18026226
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.81320469
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.74745364
4	Asthma_Homo sapiens_hsa05310	2.46560806
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.43632686
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.39391028
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.36308268
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.36052395
9	Allograft rejection_Homo sapiens_hsa05330	2.31251572
10	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.29763409
11	Basal transcription factors_Homo sapiens_hsa03022	2.22984089
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20871622
13	Taste transduction_Homo sapiens_hsa04742	2.01646241
14	Sulfur metabolism_Homo sapiens_hsa00920	2.01074414
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.00868896
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89396835
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.79370248
18	Circadian rhythm_Homo sapiens_hsa04710	1.77298391
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77161342
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.59183985
21	RNA polymerase_Homo sapiens_hsa03020	1.57829740
22	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.55225097
23	Butanoate metabolism_Homo sapiens_hsa00650	1.48417948
24	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.47851901
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43125297
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41935172
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41481411
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.41462429
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.37097568
30	Leishmaniasis_Homo sapiens_hsa05140	1.33048279
31	Proteasome_Homo sapiens_hsa03050	1.32795345
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30751494
33	Homologous recombination_Homo sapiens_hsa03440	1.30046661
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.29969372
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25720810
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.21455307
37	Morphine addiction_Homo sapiens_hsa05032	1.14761532
38	Nicotine addiction_Homo sapiens_hsa05033	1.13536769
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13107414
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09458152
41	Olfactory transduction_Homo sapiens_hsa04740	1.07847978
42	Herpes simplex infection_Homo sapiens_hsa05168	1.05319760
43	Circadian entrainment_Homo sapiens_hsa04713	1.05150886
44	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04269943
45	Parkinsons disease_Homo sapiens_hsa05012	1.03803089
46	Phototransduction_Homo sapiens_hsa04744	1.03482115
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98948035
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94123195
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.91836654
50	Serotonergic synapse_Homo sapiens_hsa04726	0.91321394
51	RNA degradation_Homo sapiens_hsa03018	0.90497031
52	Legionellosis_Homo sapiens_hsa05134	0.88244761
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87482520
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.87438631
55	Mismatch repair_Homo sapiens_hsa03430	0.82451576
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78951068
57	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78154686
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78094596
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74579443
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73983793
61	Viral myocarditis_Homo sapiens_hsa05416	0.73438168
62	Tuberculosis_Homo sapiens_hsa05152	0.70952991
63	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.70586937
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70330968
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69571009
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.66762497
67	Purine metabolism_Homo sapiens_hsa00230	0.66671113
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.65994430
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.65505626
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.63962081
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.63658758
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61856818
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60617272
74	One carbon pool by folate_Homo sapiens_hsa00670	0.60343355
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58084046
76	GABAergic synapse_Homo sapiens_hsa04727	0.56636253
77	Alzheimers disease_Homo sapiens_hsa05010	0.55441979
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53703353
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50215455
80	Measles_Homo sapiens_hsa05162	0.49928752
81	Caffeine metabolism_Homo sapiens_hsa00232	0.47888607
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47039209
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.46739692
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.45901978
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45152596
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.44465220
87	Peroxisome_Homo sapiens_hsa04146	0.44403682
88	Regulation of autophagy_Homo sapiens_hsa04140	0.43599762
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.42473423
90	ABC transporters_Homo sapiens_hsa02010	0.41383880
91	Renin secretion_Homo sapiens_hsa04924	0.40816061
92	Metabolic pathways_Homo sapiens_hsa01100	0.39828864
93	Retinol metabolism_Homo sapiens_hsa00830	0.38656903
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38266924
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37839968
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37361251
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36136501
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34768096
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33831568
100	TNF signaling pathway_Homo sapiens_hsa04668	0.32363348

EIF4A1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »