ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.96140194
2	cytidine metabolic process (GO:0046087)	7.64161713
3	cytidine catabolic process (GO:0006216)	7.64161713
4	cytidine deamination (GO:0009972)	7.64161713
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.23753990
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.65744484
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.11052022
8	actin nucleation (GO:0045010)	4.62403842
9	sequestering of actin monomers (GO:0042989)	4.32044645
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.25960346
11	positive thymic T cell selection (GO:0045059)	4.22572703
12	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.11027510
13	ATP synthesis coupled proton transport (GO:0015986)	4.08783887
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08783887
15	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.99318709
16	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.99318709
17	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.99318709
18	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.97562335
19	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.97562335
20	proteasome assembly (GO:0043248)	3.96532432
21	response to interferon-beta (GO:0035456)	3.94586313
22	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.93659598
23	regulation of cellular amino acid metabolic process (GO:0006521)	3.92179197
24	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.79875462
25	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.79875462
26	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.75967542
27	positive T cell selection (GO:0043368)	3.70310841
28	ubiquinone biosynthetic process (GO:0006744)	3.67701527
29	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.63701174
30	negative regulation of ligase activity (GO:0051352)	3.63701174
31	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.62476817
32	pyrimidine nucleoside catabolic process (GO:0046135)	3.49919100
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.47630912
34	negative regulation of viral genome replication (GO:0045071)	3.47202507
35	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.45713065
36	ubiquinone metabolic process (GO:0006743)	3.37538234
37	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.37429831
38	respiratory electron transport chain (GO:0022904)	3.27285054
39	electron transport chain (GO:0022900)	3.22342217
40	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.20808123
41	positive regulation of cell cycle arrest (GO:0071158)	3.17545349
42	protein neddylation (GO:0045116)	3.16142241
43	cell wall macromolecule metabolic process (GO:0044036)	3.15962424
44	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.13859637
45	platelet dense granule organization (GO:0060155)	3.13558626
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.12794157
47	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.11899384
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.10931963
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.10931963
50	negative T cell selection (GO:0043383)	3.09216272
51	negative regulation by host of viral transcription (GO:0043922)	3.08889928
52	cellular response to interferon-beta (GO:0035458)	3.06169686
53	positive regulation of defense response to virus by host (GO:0002230)	3.04616472
54	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.02763809
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00722667
56	negative regulation of T cell apoptotic process (GO:0070233)	2.99257123
57	positive regulation of ligase activity (GO:0051351)	2.98863277
58	positive regulation of protein homodimerization activity (GO:0090073)	2.95491091
59	positive regulation of interleukin-8 secretion (GO:2000484)	2.91742025
60	quinone biosynthetic process (GO:1901663)	2.91619885
61	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88789856
62	GPI anchor metabolic process (GO:0006505)	2.88368183
63	iron-sulfur cluster assembly (GO:0016226)	2.86134966
64	metallo-sulfur cluster assembly (GO:0031163)	2.86134966
65	regulation of cellular amine metabolic process (GO:0033238)	2.84867316
66	pseudouridine synthesis (GO:0001522)	2.83399974
67	mitochondrial DNA replication (GO:0006264)	2.79842677
68	GPI anchor biosynthetic process (GO:0006506)	2.79551829
69	protein complex biogenesis (GO:0070271)	2.78760672
70	regulation of viral genome replication (GO:0045069)	2.78489548
71	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.76997055
72	negative thymic T cell selection (GO:0045060)	2.76703538
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75014229
74	positive regulation of B cell differentiation (GO:0045579)	2.73655551
75	positive regulation of chemokine secretion (GO:0090197)	2.73218710
76	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.71629956
77	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.71629956
78	regulation of cell cycle arrest (GO:0071156)	2.70573392
79	regulation of regulatory T cell differentiation (GO:0045589)	2.66368326
80	regulation of T cell tolerance induction (GO:0002664)	2.64527047
81	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.64459582
82	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.64002414
83	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.63815689
84	positive regulation of tolerance induction (GO:0002645)	2.63039446
85	signal transduction in response to DNA damage (GO:0042770)	2.62470278
86	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.61811326
87	regulation of chronic inflammatory response (GO:0002676)	2.61428102
88	behavioral response to nicotine (GO:0035095)	2.61374489
89	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.60920827
90	cellular response to interleukin-15 (GO:0071350)	2.60439221
91	termination of RNA polymerase III transcription (GO:0006386)	2.59462736
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59462736
93	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.57981613
94	pyrimidine-containing compound catabolic process (GO:0072529)	2.57413045
95	piRNA metabolic process (GO:0034587)	2.56872173
96	cellular ketone body metabolic process (GO:0046950)	2.56829318
97	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.56355066
98	thymic T cell selection (GO:0045061)	2.56177889
99	ribosomal small subunit assembly (GO:0000028)	2.56064979
100	regulation of ligase activity (GO:0051340)	2.54975809

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.87875362
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.47947822
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.12459886
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.96774124
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.74634353
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.73641413
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.57705937
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29448243
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.11514265
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.82474814
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77044009
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.61848208
13	VDR_22108803_ChIP-Seq_LS180_Human	2.54538080
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47489632
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.35943105
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32919457
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.09906405
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.08783481
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08036613
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.07767786
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.06936370
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.02337024
23	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01824019
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.83249339
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.82500385
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.78785021
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73485611
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.72177871
29	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.71920249
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.65019578
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62712863
32	CIITA_25753668_ChIP-Seq_RAJI_Human	1.62174736
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61516947
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.58839688
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.58752403
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.55792309
37	MYB_26560356_Chip-Seq_TH2_Human	1.55424727
38	GATA3_26560356_Chip-Seq_TH2_Human	1.50897112
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.46320619
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45269820
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.44610827
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.42019035
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42005746
44	GATA3_27048872_Chip-Seq_THYMUS_Human	1.37774700
45	AR_20517297_ChIP-Seq_VCAP_Human	1.37257165
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.34886087
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29845874
48	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.29481414
49	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28248452
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28034942
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25930333
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25353782
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21960957
54	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.21872996
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20476440
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20359000
57	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19961181
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19861564
59	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18612704
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.18497151
61	NCOR_22424771_ChIP-Seq_293T_Human	1.18378406
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17962744
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17487798
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16766867
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16766867
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11812401
67	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.11101039
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.04895627
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01632761
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01627670
71	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01606791
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01368245
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01170353
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.00866991
75	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.00186060
76	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99748893
77	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.98485325
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97778106
79	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.97635238
80	STAT1_20625510_ChIP-Seq_HELA_Human	0.96753686
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96473095
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96463678
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95505603
84	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95500148
85	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.94654662
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94021602
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92741341
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.92577323
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92571366
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92477540
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92454679
92	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91090761
93	SPI1_23547873_ChIP-Seq_NB4_Human	0.91089504
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90425790
95	MYB_26560356_Chip-Seq_TH1_Human	0.90078148
96	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.90063430
97	BCL6_27268052_Chip-Seq_Bcells_Human	0.89331424
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.88288612
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.88142917
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85268502

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.63135779
2	MP0001835_abnormal_antigen_presentation	3.53920119
3	MP0009785_altered_susceptibility_to	2.84628743
4	MP0003806_abnormal_nucleotide_metabolis	2.84013021
5	MP0003011_delayed_dark_adaptation	2.74385156
6	MP0002166_altered_tumor_susceptibility	2.57301820
7	MP0000372_irregular_coat_pigmentation	2.40688955
8	MP0002138_abnormal_hepatobiliary_system	2.31411144
9	MP0002006_tumorigenesis	2.21294026
10	MP0006072_abnormal_retinal_apoptosis	2.11037861
11	MP0003646_muscle_fatigue	2.10287869
12	MP0004147_increased_porphyrin_level	2.09642000
13	MP0002148_abnormal_hypersensitivity_rea	2.03402480
14	MP0005000_abnormal_immune_tolerance	2.02760221
15	MP0003763_abnormal_thymus_physiology	2.01339862
16	MP0009333_abnormal_splenocyte_physiolog	1.99191913
17	MP0000685_abnormal_immune_system	1.93250242
18	MP0001800_abnormal_humoral_immune	1.91305862
19	MP0001919_abnormal_reproductive_system	1.86325160
20	MP0001968_abnormal_touch/_nociception	1.83281001
21	MP0002723_abnormal_immune_serum	1.78359513
22	MP0002638_abnormal_pupillary_reflex	1.73725676
23	MP0005167_abnormal_blood-brain_barrier	1.73060173
24	MP0001873_stomach_inflammation	1.72596296
25	MP0002420_abnormal_adaptive_immunity	1.72357382
26	MP0005084_abnormal_gallbladder_morpholo	1.72065420
27	MP0003786_premature_aging	1.71309312
28	MP0005387_immune_system_phenotype	1.69048188
29	MP0001790_abnormal_immune_system	1.69048188
30	MP0005253_abnormal_eye_physiology	1.68709272
31	MP0001819_abnormal_immune_cell	1.67656117
32	MP0008875_abnormal_xenobiotic_pharmacok	1.66631979
33	MP0002736_abnormal_nociception_after	1.60010615
34	MP0008872_abnormal_physiological_respon	1.54244535
35	MP0005025_abnormal_response_to	1.50154059
36	MP0002452_abnormal_antigen_presenting	1.46243888
37	MP0002837_dystrophic_cardiac_calcinosis	1.44971342
38	MP0003866_abnormal_defecation	1.43562437
39	MP0002102_abnormal_ear_morphology	1.42760914
40	MP0005389_reproductive_system_phenotype	1.39573783
41	MP0009764_decreased_sensitivity_to	1.38732959
42	MP0001764_abnormal_homeostasis	1.38110587
43	MP0005551_abnormal_eye_electrophysiolog	1.35742337
44	MP0004145_abnormal_muscle_electrophysio	1.35193229
45	MP0005075_abnormal_melanosome_morpholog	1.33989480
46	MP0002933_joint_inflammation	1.33011734
47	MP0000716_abnormal_immune_system	1.31551285
48	MP0002398_abnormal_bone_marrow	1.30751884
49	MP0003436_decreased_susceptibility_to	1.29142105
50	MP0006292_abnormal_olfactory_placode	1.28647542
51	MP0000689_abnormal_spleen_morphology	1.23346678
52	MP0003693_abnormal_embryo_hatching	1.22245252
53	MP0001986_abnormal_taste_sensitivity	1.20155723
54	MP0005367_renal/urinary_system_phenotyp	1.19455553
55	MP0000516_abnormal_urinary_system	1.19455553
56	MP0002234_abnormal_pharynx_morphology	1.18534876
57	MP0001853_heart_inflammation	1.14523239
58	MP0006036_abnormal_mitochondrial_physio	1.14117944
59	MP0010155_abnormal_intestine_physiology	1.13526722
60	MP0002722_abnormal_immune_system	1.12174049
61	MP0003195_calcinosis	1.10693499
62	MP0001845_abnormal_inflammatory_respons	1.10431506
63	MP0001905_abnormal_dopamine_level	1.08576442
64	MP0002429_abnormal_blood_cell	1.06722868
65	MP0008995_early_reproductive_senescence	1.02744835
66	MP0002277_abnormal_respiratory_mucosa	1.01611991
67	MP0005645_abnormal_hypothalamus_physiol	0.99515290
68	MP0008775_abnormal_heart_ventricle	0.96201275
69	MP0006035_abnormal_mitochondrial_morpho	0.95578488
70	MP0002405_respiratory_system_inflammati	0.93364183
71	MP0006082_CNS_inflammation	0.92198845
72	MP0005464_abnormal_platelet_physiology	0.91537620
73	MP0009763_increased_sensitivity_to	0.90838138
74	MP0001485_abnormal_pinna_reflex	0.89599524
75	MP0000703_abnormal_thymus_morphology	0.87166008
76	MP0003137_abnormal_impulse_conducting	0.85598342
77	MP0006054_spinal_hemorrhage	0.84609039
78	MP0009745_abnormal_behavioral_response	0.83949635
79	MP0001984_abnormal_olfaction	0.83210097
80	MP0008469_abnormal_protein_level	0.83148682
81	MP0005410_abnormal_fertilization	0.82204142
82	MP0003724_increased_susceptibility_to	0.81326584
83	MP0002876_abnormal_thyroid_physiology	0.80942498
84	MP0004957_abnormal_blastocyst_morpholog	0.79868819
85	MP0001661_extended_life_span	0.78668930
86	MP0002019_abnormal_tumor_incidence	0.78512699
87	MP0004043_abnormal_pH_regulation	0.77397177
88	MP0002160_abnormal_reproductive_system	0.76501036
89	MP0005360_urolithiasis	0.75732753
90	MP0010094_abnormal_chromosome_stability	0.75123805
91	MP0005636_abnormal_mineral_homeostasis	0.72907296
92	MP0003718_maternal_effect	0.72544142
93	MP0002733_abnormal_thermal_nociception	0.71952813
94	MP0003567_abnormal_fetal_cardiomyocyte	0.71368338
95	MP0002419_abnormal_innate_immunity	0.70979415
96	MP0008058_abnormal_DNA_repair	0.69670299
97	MP0010386_abnormal_urinary_bladder	0.69156728
98	MP0008007_abnormal_cellular_replicative	0.69118835
99	MP0001929_abnormal_gametogenesis	0.69058895
100	MP0005646_abnormal_pituitary_gland	0.66637267

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.34805197
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.11307341
3	Mitochondrial inheritance (HP:0001427)	4.06416821
4	Acute necrotizing encephalopathy (HP:0006965)	4.03559396
5	IgG deficiency (HP:0004315)	3.94471548
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87045472
7	Hepatocellular necrosis (HP:0001404)	3.81362261
8	Increased CSF lactate (HP:0002490)	3.74973500
9	T lymphocytopenia (HP:0005403)	3.53951916
10	Abnormality of the prostate (HP:0008775)	3.53424568
11	Increased hepatocellular lipid droplets (HP:0006565)	3.49281383
12	Acute encephalopathy (HP:0006846)	3.39187255
13	Progressive macrocephaly (HP:0004481)	3.35017270
14	Abnormality of T cell number (HP:0011839)	3.32588386
15	Hepatic necrosis (HP:0002605)	3.30677108
16	Severe combined immunodeficiency (HP:0004430)	3.29647812
17	Increased intramyocellular lipid droplets (HP:0012240)	3.26871222
18	Lipid accumulation in hepatocytes (HP:0006561)	3.24834218
19	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.23545224
20	Aplastic anemia (HP:0001915)	3.15424669
21	Decreased central vision (HP:0007663)	3.10477325
22	Renal Fanconi syndrome (HP:0001994)	3.00646362
23	Congenital stationary night blindness (HP:0007642)	2.95278992
24	Abolished electroretinogram (ERG) (HP:0000550)	2.94960714
25	Attenuation of retinal blood vessels (HP:0007843)	2.94196623
26	Increased serum lactate (HP:0002151)	2.92866823
27	Cerebral edema (HP:0002181)	2.92179091
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.85090579
29	Chronic sinusitis (HP:0011109)	2.82588715
30	Increased IgM level (HP:0003496)	2.81959246
31	Agammaglobulinemia (HP:0004432)	2.80721678
32	Hypoproteinemia (HP:0003075)	2.76492564
33	Increased muscle lipid content (HP:0009058)	2.73070816
34	Methylmalonic acidemia (HP:0002912)	2.70271052
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.68639056
36	Optic disc pallor (HP:0000543)	2.65864694
37	Lactic acidosis (HP:0003128)	2.64517865
38	Encephalitis (HP:0002383)	2.56891382
39	Abnormality of T cells (HP:0002843)	2.54698629
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.54557912
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.54557912
42	Thyroiditis (HP:0100646)	2.53021480
43	Combined immunodeficiency (HP:0005387)	2.52562382
44	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49841278
45	Pancreatic cysts (HP:0001737)	2.49642772
46	Prostate neoplasm (HP:0100787)	2.44967102
47	Panhypogammaglobulinemia (HP:0003139)	2.41756952
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.36601989
49	Dicarboxylic aciduria (HP:0003215)	2.36601989
50	Oral leukoplakia (HP:0002745)	2.33401886
51	Microvesicular hepatic steatosis (HP:0001414)	2.31718105
52	Exercise intolerance (HP:0003546)	2.30372544
53	Recurrent bronchitis (HP:0002837)	2.29667198
54	Respiratory failure (HP:0002878)	2.27585715
55	Methylmalonic aciduria (HP:0012120)	2.23332332
56	Pancytopenia (HP:0001876)	2.23178216
57	IgM deficiency (HP:0002850)	2.21119615
58	Autoimmune hemolytic anemia (HP:0001890)	2.19719611
59	Congenital, generalized hypertrichosis (HP:0004540)	2.19474387
60	True hermaphroditism (HP:0010459)	2.13340613
61	CNS demyelination (HP:0007305)	2.11885623
62	Abnormality of eosinophils (HP:0001879)	2.11859808
63	Type I transferrin isoform profile (HP:0003642)	2.10173341
64	Testicular atrophy (HP:0000029)	2.04712685
65	Pendular nystagmus (HP:0012043)	2.04605125
66	Abnormality of male internal genitalia (HP:0000022)	2.01795816
67	Emotional lability (HP:0000712)	2.01442826
68	Agitation (HP:0000713)	2.01270844
69	Keratoconus (HP:0000563)	1.99969529
70	Increased corneal curvature (HP:0100692)	1.99969529
71	Lethargy (HP:0001254)	1.99238701
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97300485
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.94680202
74	Chronic diarrhea (HP:0002028)	1.93975873
75	Abnormality of B cell number (HP:0010975)	1.93353501
76	Hypoplasia of the uterus (HP:0000013)	1.92518905
77	Abnormality of midbrain morphology (HP:0002418)	1.92237851
78	Molar tooth sign on MRI (HP:0002419)	1.92237851
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.91806085
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91806085
81	Delayed CNS myelination (HP:0002188)	1.90584957
82	Cerebral hypomyelination (HP:0006808)	1.90538159
83	Meningitis (HP:0001287)	1.90435311
84	Cerebral palsy (HP:0100021)	1.89387737
85	Exertional dyspnea (HP:0002875)	1.88450338
86	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.85598619
87	Abnormal protein N-linked glycosylation (HP:0012347)	1.85598619
88	Abnormal protein glycosylation (HP:0012346)	1.85598619
89	Abnormal glycosylation (HP:0012345)	1.85598619
90	Eosinophilia (HP:0001880)	1.85188655
91	Abnormality of DNA repair (HP:0003254)	1.84254084
92	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.82567011
93	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.82100096
94	Absent thumb (HP:0009777)	1.81215652
95	Stomatitis (HP:0010280)	1.80996951
96	Abnormal biliary tract physiology (HP:0012439)	1.80460591
97	Bile duct proliferation (HP:0001408)	1.80460591
98	Abnormality of T cell physiology (HP:0011840)	1.79578363
99	Abnormality of renal resorption (HP:0011038)	1.78432319
100	Amyotrophic lateral sclerosis (HP:0007354)	1.77649683

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	6.78792921
2	TXK	4.12866231
3	KDR	4.03560983
4	MAPKAPK3	3.39402601
5	GRK1	2.69383083
6	TIE1	2.63828397
7	ZAK	2.37434984
8	VRK2	2.25476920
9	BCKDK	2.07676976
10	ADRBK2	2.03016569
11	MAP4K1	1.98019272
12	STK16	1.97768307
13	LIMK1	1.96810425
14	TLK1	1.91690791
15	TAOK3	1.90784510
16	TESK1	1.78338262
17	MAP4K2	1.71426274
18	SRPK1	1.50369951
19	FRK	1.50286882
20	BMPR1B	1.49902578
21	BUB1	1.48880807
22	MST4	1.41498832
23	ITK	1.36989232
24	TAF1	1.31358554
25	PINK1	1.30354177
26	CSF1R	1.29718089
27	EIF2AK3	1.27832703
28	VRK1	1.24274717
29	DAPK1	1.23953743
30	PIM2	1.23250500
31	NUAK1	1.22305412
32	CAMKK2	1.21428256
33	TEC	1.12228888
34	MAP3K12	1.06494599
35	SYK	1.00781858
36	RPS6KA4	0.96747131
37	CSNK1G3	0.94957903
38	KIT	0.90779925
39	WNK3	0.88450787
40	PRKCQ	0.87550650
41	SCYL2	0.87431243
42	IKBKE	0.84119231
43	MAP2K7	0.83030663
44	FES	0.81253851
45	WNK4	0.81118626
46	TRIM28	0.79689013
47	MAPK13	0.79155440
48	CDC7	0.79150779
49	LCK	0.74815115
50	RPS6KA5	0.73576073
51	MAP3K11	0.71421769
52	IKBKB	0.69280203
53	INSRR	0.69155215
54	PHKG2	0.67584006
55	PHKG1	0.67584006
56	TBK1	0.66741164
57	CSNK1A1L	0.65637096
58	ERBB3	0.64355702
59	ATR	0.63619560
60	AURKA	0.63232852
61	CSNK1G1	0.62371434
62	LYN	0.61777222
63	MAP2K6	0.60972614
64	CSNK1G2	0.59988244
65	DYRK2	0.59612637
66	GRK7	0.58561058
67	ACVR1B	0.57719104
68	SIK3	0.57551723
69	MAP3K4	0.56544210
70	MAP3K5	0.56471476
71	NME1	0.55494682
72	OXSR1	0.52904899
73	ADRBK1	0.52821374
74	GRK6	0.49798900
75	MAPK11	0.46857799
76	TRPM7	0.46077139
77	BTK	0.44326599
78	PDK2	0.43336863
79	BCR	0.43189795
80	EIF2AK2	0.40799277
81	MAPKAPK5	0.40375045
82	MATK	0.39532768
83	IGF1R	0.38242507
84	PLK4	0.37774721
85	NEK1	0.37707259
86	CSNK2A1	0.36648262
87	GRK5	0.34029785
88	PLK1	0.33564515
89	PLK2	0.32526469
90	STK10	0.32464937
91	PLK3	0.31660303
92	CSK	0.31302494
93	STK39	0.31216323
94	ABL1	0.30521175
95	RPS6KB2	0.30222637
96	PRKCA	0.29335561
97	PIM1	0.28848893
98	AURKB	0.28560716
99	FYN	0.27971420
100	PRKACA	0.27925755

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.23379627
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.65878183
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06709672
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.72229808
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.70369955
6	Parkinsons disease_Homo sapiens_hsa05012	2.68188650
7	Allograft rejection_Homo sapiens_hsa05330	2.55162500
8	Asthma_Homo sapiens_hsa05310	2.39259260
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.35114303
10	RNA polymerase_Homo sapiens_hsa03020	2.26880420
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.24697060
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.19661489
13	Phototransduction_Homo sapiens_hsa04744	2.08720207
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.04160478
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99057082
16	Homologous recombination_Homo sapiens_hsa03440	1.65775464
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64766372
18	Alzheimers disease_Homo sapiens_hsa05010	1.64448718
19	Protein export_Homo sapiens_hsa03060	1.58387803
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.58187124
21	Ribosome_Homo sapiens_hsa03010	1.57212995
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52004103
23	Huntingtons disease_Homo sapiens_hsa05016	1.51803410
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.50126526
25	Propanoate metabolism_Homo sapiens_hsa00640	1.46317964
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39013480
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25584158
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24275579
29	RNA degradation_Homo sapiens_hsa03018	1.24108761
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23337383
31	DNA replication_Homo sapiens_hsa03030	1.21458719
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.21324154
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17434825
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.13361040
35	Peroxisome_Homo sapiens_hsa04146	1.12332780
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.12144546
37	Purine metabolism_Homo sapiens_hsa00230	1.03997075
38	Butanoate metabolism_Homo sapiens_hsa00650	1.03694204
39	Spliceosome_Homo sapiens_hsa03040	1.00743623
40	Mismatch repair_Homo sapiens_hsa03430	0.98855404
41	One carbon pool by folate_Homo sapiens_hsa00670	0.98790124
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97754923
43	Viral myocarditis_Homo sapiens_hsa05416	0.97599110
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97300696
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97244833
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97019028
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.95733905
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.94912314
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.93772873
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81828689
51	Olfactory transduction_Homo sapiens_hsa04740	0.79938912
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.77956781
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77683005
54	Shigellosis_Homo sapiens_hsa05131	0.75118777
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74315940
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.74314556
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.73700507
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69214950
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.69103543
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67344345
61	Basal transcription factors_Homo sapiens_hsa03022	0.67199028
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64606732
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64319175
64	Fatty acid elongation_Homo sapiens_hsa00062	0.63686579
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.62409296
66	Sulfur metabolism_Homo sapiens_hsa00920	0.62205301
67	Retinol metabolism_Homo sapiens_hsa00830	0.61084237
68	Base excision repair_Homo sapiens_hsa03410	0.59275266
69	Caffeine metabolism_Homo sapiens_hsa00232	0.57723847
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.56929433
71	Metabolic pathways_Homo sapiens_hsa01100	0.56625974
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.56603440
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56299365
74	RNA transport_Homo sapiens_hsa03013	0.55904406
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.51948919
76	Measles_Homo sapiens_hsa05162	0.50857513
77	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.50733623
78	Herpes simplex infection_Homo sapiens_hsa05168	0.47908277
79	Sulfur relay system_Homo sapiens_hsa04122	0.47827274
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47236660
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45401930
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.44679304
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43788557
84	Salmonella infection_Homo sapiens_hsa05132	0.40949499
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40483176
86	Taste transduction_Homo sapiens_hsa04742	0.38730813
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38243761
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37838633
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.37791176
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37045755
91	Folate biosynthesis_Homo sapiens_hsa00790	0.36882822
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35607863
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35313107
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35131645
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34385054
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32774155
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32183193
98	Morphine addiction_Homo sapiens_hsa05032	0.31473214
99	p53 signaling pathway_Homo sapiens_hsa04115	0.29697921
100	Glutathione metabolism_Homo sapiens_hsa00480	0.27452463

EIF4A1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »