ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transcription from mitochondrial promoter (GO:0006390)	7.57318751
2	synapsis (GO:0007129)	7.55692036
3	piRNA metabolic process (GO:0034587)	7.37431388
4	rRNA methylation (GO:0031167)	6.51897922
5	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.45750381
6	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.45750381
7	DNA methylation involved in gamete generation (GO:0043046)	6.10678941
8	folic acid-containing compound biosynthetic process (GO:0009396)	6.10278685
9	rRNA modification (GO:0000154)	6.08650161
10	purine nucleotide salvage (GO:0032261)	6.00866178
11	homocysteine metabolic process (GO:0050667)	5.70268627
12	mitochondrial RNA metabolic process (GO:0000959)	5.39555932
13	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.34896554
14	regulation of plasminogen activation (GO:0010755)	5.15585656
15	alternative mRNA splicing, via spliceosome (GO:0000380)	4.92430075
16	phosphatidylglycerol biosynthetic process (GO:0006655)	4.73222925
17	white fat cell differentiation (GO:0050872)	4.66648847
18	energy homeostasis (GO:0097009)	4.64407905
19	male meiosis (GO:0007140)	4.56172275
20	kynurenine metabolic process (GO:0070189)	4.52473392
21	sulfur amino acid catabolic process (GO:0000098)	4.46563805
22	male meiosis I (GO:0007141)	4.35622044
23	nucleotide salvage (GO:0043173)	4.29644133
24	adenosine metabolic process (GO:0046085)	4.23048871
25	DNA deamination (GO:0045006)	4.22176576
26	tryptophan catabolic process (GO:0006569)	4.15562148
27	indole-containing compound catabolic process (GO:0042436)	4.15562148
28	indolalkylamine catabolic process (GO:0046218)	4.15562148
29	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.92927432
30	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.92927432
31	isotype switching (GO:0045190)	3.92927432
32	negative regulation of DNA biosynthetic process (GO:2000279)	3.90814630
33	microtubule nucleation (GO:0007020)	3.80874820
34	pseudouridine synthesis (GO:0001522)	3.80058108
35	regulation of mitotic spindle checkpoint (GO:1903504)	3.71659123
36	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.71659123
37	poly(A)+ mRNA export from nucleus (GO:0016973)	3.71609623
38	GMP metabolic process (GO:0046037)	3.71261293
39	positive regulation of granulocyte differentiation (GO:0030854)	3.68604845
40	chromosome organization involved in meiosis (GO:0070192)	3.64870327
41	pteridine-containing compound biosynthetic process (GO:0042559)	3.60353804
42	nucleoside transmembrane transport (GO:1901642)	3.60065481
43	tryptophan metabolic process (GO:0006568)	3.51969895
44	IMP biosynthetic process (GO:0006188)	3.47295530
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45523444
46	NADH dehydrogenase complex assembly (GO:0010257)	3.45523444
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45523444
48	DNA double-strand break processing (GO:0000729)	3.44198431
49	aminoglycoside antibiotic metabolic process (GO:0030647)	3.39835864
50	regulation of vitamin D biosynthetic process (GO:0060556)	3.38464362
51	folic acid-containing compound metabolic process (GO:0006760)	3.32653969
52	proteasome assembly (GO:0043248)	3.31467363
53	inner ear receptor cell development (GO:0060119)	3.30433155
54	cysteine metabolic process (GO:0006534)	3.29037702
55	regulation of meiosis I (GO:0060631)	3.26925422
56	platelet dense granule organization (GO:0060155)	3.26402499
57	histone H4-K12 acetylation (GO:0043983)	3.25502068
58	protein complex biogenesis (GO:0070271)	3.24129019
59	meiotic nuclear division (GO:0007126)	3.20803364
60	positive regulation of endothelial cell differentiation (GO:0045603)	3.19401190
61	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.14556245
62	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.14556245
63	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.14556245
64	tetrahydrofolate metabolic process (GO:0046653)	3.11665835
65	forebrain morphogenesis (GO:0048853)	3.10502321
66	inner mitochondrial membrane organization (GO:0007007)	3.09675776
67	protein-chromophore linkage (GO:0018298)	3.06144246
68	regulation of sequestering of triglyceride (GO:0010889)	3.03705845
69	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.02732400
70	gene silencing by RNA (GO:0031047)	3.02433924
71	mRNA splice site selection (GO:0006376)	3.01830389
72	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.01053024
73	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.98992401
74	short-chain fatty acid metabolic process (GO:0046459)	2.98559964
75	cell migration involved in heart development (GO:0060973)	2.98063512
76	negative regulation of Ras GTPase activity (GO:0034261)	2.97629262
77	guanosine-containing compound biosynthetic process (GO:1901070)	2.97189748
78	tRNA modification (GO:0006400)	2.96832366
79	positive regulation of cell cycle checkpoint (GO:1901978)	2.94140198
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.92639249
81	negative regulation of cell aging (GO:0090344)	2.91642381
82	meiosis I (GO:0007127)	2.90454182
83	regulation of immunoglobulin secretion (GO:0051023)	2.90213507
84	inositol phosphate catabolic process (GO:0071545)	2.88095962
85	purine-containing compound salvage (GO:0043101)	2.86732064
86	interkinetic nuclear migration (GO:0022027)	2.86070382
87	behavioral defense response (GO:0002209)	2.84611636
88	behavioral fear response (GO:0001662)	2.84611636
89	IMP metabolic process (GO:0046040)	2.83675422
90	DNA synthesis involved in DNA repair (GO:0000731)	2.80268170
91	heme transport (GO:0015886)	2.78777965
92	GTP biosynthetic process (GO:0006183)	2.77420451
93	regulation of vitamin metabolic process (GO:0030656)	2.75267007
94	reciprocal DNA recombination (GO:0035825)	2.75038512
95	reciprocal meiotic recombination (GO:0007131)	2.75038512
96	positive regulation of meiosis (GO:0045836)	2.74819729
97	primary amino compound metabolic process (GO:1901160)	2.73962963
98	organic cation transport (GO:0015695)	2.72556871
99	cartilage morphogenesis (GO:0060536)	2.72407680
100	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.70750919

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.50061079
2	VDR_22108803_ChIP-Seq_LS180_Human	3.02710412
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.99326711
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78759018
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.69927715
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67189663
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.43567719
8	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.36099419
9	FUS_26573619_Chip-Seq_HEK293_Human	2.33290214
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.27775841
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12746147
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.11835638
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.02494008
14	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.94744297
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.92369531
16	EWS_26573619_Chip-Seq_HEK293_Human	1.81107936
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.79987395
18	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.78067653
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77009431
20	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.76176818
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74002032
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70966332
23	SCL_19346495_ChIP-Seq_HPC-7_Human	1.64987456
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60722994
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52143065
26	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49339124
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48031110
28	CDX2_22108803_ChIP-Seq_LS180_Human	1.47749448
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.42376504
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.40640277
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39660376
32	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.38882835
33	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38343140
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38343140
35	P300_19829295_ChIP-Seq_ESCs_Human	1.38095851
36	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.37281596
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37258884
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37258884
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36608840
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.32061057
41	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.29883264
42	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.29883264
43	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.29883264
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27177344
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23885832
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23592895
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23507070
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21604965
49	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.21349093
50	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.21055305
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19803682
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.19424032
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19424032
54	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14886753
55	MYB_26560356_Chip-Seq_TH2_Human	1.14314704
56	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14281460
57	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14219553
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13954605
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11613703
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09737307
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09718999
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08937546
63	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08410204
64	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07805721
65	GATA1_22025678_ChIP-Seq_K562_Human	1.07786864
66	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06896377
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05734773
68	GATA3_26560356_Chip-Seq_TH1_Human	1.05675496
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05196371
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04619917
71	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04105293
72	NCOR_22424771_ChIP-Seq_293T_Human	1.03055492
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01792658
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.00861567
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99565330
76	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.99547924
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99466290
78	GATA3_26560356_Chip-Seq_TH2_Human	0.99250347
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98806169
80	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98667594
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98111896
82	AR_20517297_ChIP-Seq_VCAP_Human	0.97598016
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97204791
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96270755
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.95831638
86	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95304910
87	FOXP3_21729870_ChIP-Seq_TREG_Human	0.95277823
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95117857
89	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94387262
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94197002
91	STAT1_20625510_ChIP-Seq_HELA_Human	0.94138456
92	P300_18555785_Chip-Seq_ESCs_Mouse	0.93932321
93	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.93231910
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.92752957
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92596936
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91920690
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91001654
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.90705057
99	AR_25329375_ChIP-Seq_VCAP_Human	0.90639104
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90627957

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.81913755
2	MP0008995_early_reproductive_senescence	4.52271097
3	MP0005646_abnormal_pituitary_gland	3.82527408
4	MP0000013_abnormal_adipose_tissue	3.49818705
5	MP0005360_urolithiasis	3.35313012
6	MP0002396_abnormal_hematopoietic_system	3.34694421
7	MP0003724_increased_susceptibility_to	3.27490871
8	MP0006292_abnormal_olfactory_placode	3.10106610
9	MP0002102_abnormal_ear_morphology	2.81212671
10	MP0008875_abnormal_xenobiotic_pharmacok	2.52703660
11	MP0001545_abnormal_hematopoietic_system	2.22638153
12	MP0005397_hematopoietic_system_phenotyp	2.22638153
13	MP0001661_extended_life_span	2.04935780
14	MP0005367_renal/urinary_system_phenotyp	2.04217048
15	MP0000516_abnormal_urinary_system	2.04217048
16	MP0005645_abnormal_hypothalamus_physiol	2.01566306
17	MP0002160_abnormal_reproductive_system	2.00800857
18	MP0005647_abnormal_sex_gland	1.98918252
19	MP0002938_white_spotting	1.77866580
20	MP0008872_abnormal_physiological_respon	1.76974203
21	MP0005084_abnormal_gallbladder_morpholo	1.74027416
22	MP0003186_abnormal_redox_activity	1.67873631
23	MP0001835_abnormal_antigen_presentation	1.62935826
24	MP0008058_abnormal_DNA_repair	1.62042506
25	MP0005389_reproductive_system_phenotype	1.57962611
26	MP0002006_tumorigenesis	1.50287564
27	MP0000653_abnormal_sex_gland	1.46363041
28	MP0001145_abnormal_male_reproductive	1.43558831
29	MP0003806_abnormal_nucleotide_metabolis	1.43214350
30	MP0001944_abnormal_pancreas_morphology	1.42561042
31	MP0005670_abnormal_white_adipose	1.42123353
32	MP0006072_abnormal_retinal_apoptosis	1.40651870
33	MP0003786_premature_aging	1.39987791
34	MP0005332_abnormal_amino_acid	1.39968704
35	MP0003183_abnormal_peptide_metabolism	1.39707458
36	MP0002210_abnormal_sex_determination	1.36552517
37	MP0002095_abnormal_skin_pigmentation	1.33407075
38	MP0001764_abnormal_homeostasis	1.32853440
39	MP0002009_preneoplasia	1.30699862
40	MP0008789_abnormal_olfactory_epithelium	1.27991378
41	MP0003638_abnormal_response/metabolism_	1.24131325
42	MP0005671_abnormal_response_to	1.24019358
43	MP0001929_abnormal_gametogenesis	1.22396397
44	MP0003698_abnormal_male_reproductive	1.21871068
45	MP0000631_abnormal_neuroendocrine_gland	1.17525473
46	MP0005220_abnormal_exocrine_pancreas	1.14949874
47	MP0005551_abnormal_eye_electrophysiolog	1.13540924
48	MP0000383_abnormal_hair_follicle	1.12346662
49	MP0004808_abnormal_hematopoietic_stem	1.11533643
50	MP0001800_abnormal_humoral_immune	1.09349049
51	MP0002166_altered_tumor_susceptibility	1.09300191
52	MP0009785_altered_susceptibility_to	1.08161799
53	MP0002736_abnormal_nociception_after	1.06268698
54	MP0003787_abnormal_imprinting	1.03478141
55	MP0004185_abnormal_adipocyte_glucose	1.02799939
56	MP0001119_abnormal_female_reproductive	0.99247865
57	MP0005394_taste/olfaction_phenotype	0.99083987
58	MP0005499_abnormal_olfactory_system	0.99083987
59	MP0002277_abnormal_respiratory_mucosa	0.98198046
60	MP0006082_CNS_inflammation	0.93866988
61	MP0002234_abnormal_pharynx_morphology	0.93805820
62	MP0005636_abnormal_mineral_homeostasis	0.93449594
63	MP0000465_gastrointestinal_hemorrhage	0.92435866
64	MP0004147_increased_porphyrin_level	0.92007208
65	MP0004885_abnormal_endolymph	0.90461398
66	MP0005075_abnormal_melanosome_morpholog	0.90297014
67	MP0004043_abnormal_pH_regulation	0.90225778
68	MP0002693_abnormal_pancreas_physiology	0.90211176
69	MP0005167_abnormal_blood-brain_barrier	0.88542697
70	MP0000681_abnormal_thyroid_gland	0.86948232
71	MP0003763_abnormal_thymus_physiology	0.86646548
72	MP0004133_heterotaxia	0.85374469
73	MP0000003_abnormal_adipose_tissue	0.84644795
74	MP0002735_abnormal_chemical_nociception	0.83694771
75	MP0002638_abnormal_pupillary_reflex	0.83256734
76	MP0000371_diluted_coat_color	0.82895446
77	MP0002398_abnormal_bone_marrow	0.81827640
78	MP0002876_abnormal_thyroid_physiology	0.79278695
79	MP0005410_abnormal_fertilization	0.78379107
80	MP0005584_abnormal_enzyme/coenzyme_acti	0.77687370
81	MP0005310_abnormal_salivary_gland	0.76683624
82	MP0006036_abnormal_mitochondrial_physio	0.76618374
83	MP0000703_abnormal_thymus_morphology	0.76561798
84	MP0010678_abnormal_skin_adnexa	0.75916271
85	MP0001919_abnormal_reproductive_system	0.75018742
86	MP0001501_abnormal_sleep_pattern	0.74632414
87	MP0002078_abnormal_glucose_homeostasis	0.74469038
88	MP0005503_abnormal_tendon_morphology	0.74394745
89	MP0001968_abnormal_touch/_nociception	0.74348101
90	MP0002723_abnormal_immune_serum	0.73131568
91	MP0002837_dystrophic_cardiac_calcinosis	0.72863052
92	MP0001963_abnormal_hearing_physiology	0.69531735
93	MP0009333_abnormal_splenocyte_physiolog	0.69012464
94	MP0001486_abnormal_startle_reflex	0.67795705
95	MP0002928_abnormal_bile_duct	0.67734449
96	MP0005253_abnormal_eye_physiology	0.67455737
97	MP0000716_abnormal_immune_system	0.65703352
98	MP0000689_abnormal_spleen_morphology	0.65172440
99	MP0004145_abnormal_muscle_electrophysio	0.65076634
100	MP0002229_neurodegeneration	0.61865398

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.52912710
2	Abnormality of alanine metabolism (HP:0010916)	6.52912710
3	Hyperalaninemia (HP:0003348)	6.52912710
4	Constricted visual fields (HP:0001133)	6.16292493
5	Stomatitis (HP:0010280)	4.90735738
6	Spontaneous hematomas (HP:0007420)	3.76575842
7	Esophageal varix (HP:0002040)	3.72260566
8	Congenital sensorineural hearing impairment (HP:0008527)	3.67486605
9	Homocystinuria (HP:0002156)	3.45408230
10	Abnormality of homocysteine metabolism (HP:0010919)	3.45408230
11	Attenuation of retinal blood vessels (HP:0007843)	3.36898146
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.29214580
13	Abnormality of the lower motor neuron (HP:0002366)	3.20816691
14	Pulmonary embolism (HP:0002204)	3.10070079
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.01972410
16	Abnormality of serum amino acid levels (HP:0003112)	2.93471753
17	Amyotrophic lateral sclerosis (HP:0007354)	2.92436450
18	Chorioretinal atrophy (HP:0000533)	2.91489067
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.87473465
20	Increased IgM level (HP:0003496)	2.85490774
21	Upper motor neuron abnormality (HP:0002127)	2.85015304
22	Petechiae (HP:0000967)	2.84970417
23	Ketoacidosis (HP:0001993)	2.68453397
24	Action tremor (HP:0002345)	2.68319670
25	Tubulointerstitial nephritis (HP:0001970)	2.68244655
26	Anorexia (HP:0002039)	2.66934899
27	Prolonged bleeding time (HP:0003010)	2.61346016
28	Type I diabetes mellitus (HP:0100651)	2.58331609
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.58153009
30	Posterior subcapsular cataract (HP:0007787)	2.54245237
31	Methylmalonic acidemia (HP:0002912)	2.49989237
32	Increased hepatocellular lipid droplets (HP:0006565)	2.47738300
33	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.46858270
34	Thyroid-stimulating hormone excess (HP:0002925)	2.45525267
35	Lipid accumulation in hepatocytes (HP:0006561)	2.23804172
36	Thrombophlebitis (HP:0004418)	2.23244403
37	Limb dystonia (HP:0002451)	2.19037850
38	Neoplasm of the adrenal cortex (HP:0100641)	2.18360693
39	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17940788
40	Purpura (HP:0000979)	2.12956590
41	Hyperglycemia (HP:0003074)	2.12287590
42	Volvulus (HP:0002580)	2.12139465
43	Abnormality of methionine metabolism (HP:0010901)	2.11933140
44	Abnormality of the phalanges of the hallux (HP:0010057)	2.11226607
45	Myositis (HP:0100614)	2.10164103
46	Maternal diabetes (HP:0009800)	2.08942127
47	Abnormality of midbrain morphology (HP:0002418)	2.08851287
48	Molar tooth sign on MRI (HP:0002419)	2.08851287
49	Abnormal umbilical cord blood vessels (HP:0011403)	2.07610940
50	Single umbilical artery (HP:0001195)	2.07610940
51	Abnormality of the fetal cardiovascular system (HP:0010948)	2.07610940
52	Chronic otitis media (HP:0000389)	2.07084143
53	Hyperglycinemia (HP:0002154)	2.06563887
54	Chronic hepatic failure (HP:0100626)	2.04734910
55	Hematochezia (HP:0002573)	2.04281722
56	Conjugated hyperbilirubinemia (HP:0002908)	2.03415936
57	Arterial thrombosis (HP:0004420)	2.01871377
58	Abolished electroretinogram (ERG) (HP:0000550)	2.01235674
59	White forelock (HP:0002211)	1.99967022
60	Nephronophthisis (HP:0000090)	1.99429689
61	Type 2 muscle fiber atrophy (HP:0003554)	1.99320081
62	Epistaxis (HP:0000421)	1.98582048
63	Fatigue (HP:0012378)	1.96425148
64	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96216401
65	Gonadotropin excess (HP:0000837)	1.94705372
66	Symptomatic seizures (HP:0011145)	1.92800805
67	Portal hypertension (HP:0001409)	1.91720307
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.90288155
69	Conjunctival telangiectasia (HP:0000524)	1.89246710
70	Shoulder girdle muscle weakness (HP:0003547)	1.88103847
71	Elevated erythrocyte sedimentation rate (HP:0003565)	1.87749038
72	Patchy hypopigmentation of hair (HP:0011365)	1.86973656
73	Insulin-resistant diabetes mellitus (HP:0000831)	1.85872189
74	Abnormality of the labia minora (HP:0012880)	1.84995228
75	Unsteady gait (HP:0002317)	1.82647668
76	Abnormality of renal resorption (HP:0011038)	1.80900504
77	Neutropenia (HP:0001875)	1.80423338
78	Gingival bleeding (HP:0000225)	1.79193636
79	Adactyly (HP:0009776)	1.79112032
80	Heterochromia iridis (HP:0001100)	1.77047279
81	Abnormality of T cell physiology (HP:0011840)	1.77006909
82	Duplicated collecting system (HP:0000081)	1.76860412
83	Methylmalonic aciduria (HP:0012120)	1.76841538
84	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76584129
85	Abnormality of glycine metabolism (HP:0010895)	1.76584129
86	Congenital stationary night blindness (HP:0007642)	1.75919666
87	Panhypogammaglobulinemia (HP:0003139)	1.74655717
88	Hypergammaglobulinemia (HP:0010702)	1.74424513
89	Postural tremor (HP:0002174)	1.74386858
90	Arteriovenous malformation (HP:0100026)	1.74213165
91	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.73191314
92	IgG deficiency (HP:0004315)	1.72616951
93	Hypergonadotropic hypogonadism (HP:0000815)	1.72226289
94	Azoospermia (HP:0000027)	1.71792454
95	Abnormal spermatogenesis (HP:0008669)	1.70889217
96	Abnormality of the renal collecting system (HP:0004742)	1.70682580
97	Cavernous hemangioma (HP:0001048)	1.69622538
98	Abnormality of the hepatic vasculature (HP:0006707)	1.69462089
99	Increased serum lactate (HP:0002151)	1.69149166
100	Ketosis (HP:0001946)	1.67226734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	4.67425305
2	NUAK1	4.19472924
3	FRK	3.73358853
4	MAP4K2	3.29473246
5	ZAK	2.73785042
6	STK38L	2.57190894
7	BCKDK	2.42807082
8	JAK3	2.36623486
9	PASK	2.33892475
10	PIM2	2.10209852
11	RPS6KB2	2.05694701
12	ACVR1B	2.00112165
13	TXK	1.98443697
14	VRK2	1.95256323
15	PNCK	1.94018952
16	CDK19	1.84695727
17	CDK9	1.78533298
18	TAF1	1.72520142
19	FGR	1.66666579
20	MAP4K1	1.49977707
21	EIF2AK2	1.48732786
22	FGFR2	1.47003675
23	WNK3	1.46934338
24	DAPK2	1.44566306
25	ADRBK2	1.36036314
26	MAP3K3	1.35696948
27	GRK7	1.24701079
28	RPS6KB1	1.23004652
29	MST4	1.21713987
30	PLK4	1.19484854
31	MAP2K3	1.11207978
32	IKBKB	1.10628031
33	VRK1	1.06724408
34	SCYL2	1.05042893
35	NTRK2	0.98824131
36	CSNK1G3	0.98570161
37	GRK5	0.95013394
38	MAP2K2	0.90923401
39	CSNK1G2	0.88317482
40	BRD4	0.87003563
41	BMPR2	0.86072668
42	RAF1	0.85298843
43	CDK6	0.84452854
44	MAP3K14	0.80072487
45	CSNK1G1	0.79477267
46	FGFR3	0.77785466
47	IKBKE	0.77679006
48	WNK1	0.77447139
49	ERBB3	0.76132715
50	PLK2	0.73434224
51	RPS6KA6	0.69146173
52	MAPKAPK5	0.66586477
53	MKNK1	0.66058115
54	CSNK1A1L	0.65928938
55	RPS6KC1	0.65712006
56	RPS6KL1	0.65712006
57	PLK3	0.65647031
58	DYRK2	0.64100046
59	GRK1	0.63649119
60	PAK2	0.61590296
61	MAPK7	0.59688629
62	TAOK2	0.57707703
63	CSNK1A1	0.56899944
64	MAP3K13	0.55369282
65	OXSR1	0.54103647
66	BTK	0.53829036
67	RPS6KA5	0.52802634
68	ADRBK1	0.51231994
69	CAMK1	0.50128770
70	NTRK3	0.50012377
71	HIPK2	0.49943516
72	PKN1	0.49328428
73	EIF2AK1	0.49131381
74	RPS6KA4	0.48815370
75	TGFBR2	0.46641901
76	SYK	0.45431465
77	PRKCQ	0.45302207
78	STK3	0.44160594
79	ITK	0.43941256
80	GSK3A	0.43610692
81	BCR	0.43594408
82	DYRK3	0.41939592
83	TBK1	0.41430755
84	NEK1	0.40266954
85	PRKCE	0.40063431
86	ALK	0.39328480
87	STK24	0.38761358
88	LCK	0.38034314
89	JAK2	0.36198650
90	PDK2	0.36141890
91	PIM1	0.35952553
92	PRKAA2	0.35719052
93	STK11	0.35275240
94	RPS6KA1	0.34377299
95	DMPK	0.32794283
96	ATM	0.32662709
97	CAMK2D	0.32094992
98	SGK2	0.31137314
99	PINK1	0.31010208
100	SRPK1	0.29428709

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	6.78001438
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.86414750
3	One carbon pool by folate_Homo sapiens_hsa00670	3.30116135
4	Asthma_Homo sapiens_hsa05310	2.88958863
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.67172067
6	Allograft rejection_Homo sapiens_hsa05330	2.46733030
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.29771870
8	Propanoate metabolism_Homo sapiens_hsa00640	2.09994543
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.05952671
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04937215
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03947871
12	Rheumatoid arthritis_Homo sapiens_hsa05323	1.89100845
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.79425789
14	Regulation of autophagy_Homo sapiens_hsa04140	1.78692406
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.76770553
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.74254533
17	Protein export_Homo sapiens_hsa03060	1.71935455
18	RNA degradation_Homo sapiens_hsa03018	1.63706052
19	Arginine biosynthesis_Homo sapiens_hsa00220	1.54734999
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50866678
21	Sulfur metabolism_Homo sapiens_hsa00920	1.48538723
22	Sulfur relay system_Homo sapiens_hsa04122	1.44951969
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39507458
24	Olfactory transduction_Homo sapiens_hsa04740	1.37216846
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.29763156
26	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.28465339
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.27719844
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25828439
29	Sphingolipid metabolism_Homo sapiens_hsa00600	1.24209320
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.20893625
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.18388964
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.17008166
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.16768353
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14951235
35	Butanoate metabolism_Homo sapiens_hsa00650	1.07922463
36	GABAergic synapse_Homo sapiens_hsa04727	1.07574416
37	Basal transcription factors_Homo sapiens_hsa03022	1.04207267
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04004287
39	Proteasome_Homo sapiens_hsa03050	1.02686870
40	Morphine addiction_Homo sapiens_hsa05032	1.01385580
41	RNA transport_Homo sapiens_hsa03013	0.98391895
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90604736
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88434584
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84959105
45	Serotonergic synapse_Homo sapiens_hsa04726	0.84935575
46	Oxidative phosphorylation_Homo sapiens_hsa00190	0.83593176
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83001026
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81937529
49	Peroxisome_Homo sapiens_hsa04146	0.80121268
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.77816566
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68404891
52	RNA polymerase_Homo sapiens_hsa03020	0.66507976
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66363185
54	Nicotine addiction_Homo sapiens_hsa05033	0.65195345
55	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64405111
56	Homologous recombination_Homo sapiens_hsa03440	0.62955741
57	Taste transduction_Homo sapiens_hsa04742	0.61624761
58	Phototransduction_Homo sapiens_hsa04744	0.61071349
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59140258
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58729552
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.57680293
62	Circadian entrainment_Homo sapiens_hsa04713	0.54882083
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53271974
64	Fatty acid degradation_Homo sapiens_hsa00071	0.51342857
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51078122
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50334004
67	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.50311556
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49724802
69	Metabolic pathways_Homo sapiens_hsa01100	0.48535037
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47821657
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.47380027
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45770951
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.45707541
74	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45351998
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44691460
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43416033
77	Purine metabolism_Homo sapiens_hsa00230	0.43057810
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42845517
79	Herpes simplex infection_Homo sapiens_hsa05168	0.42115018
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41943267
81	Spliceosome_Homo sapiens_hsa03040	0.39435273
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.38769905
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38374696
84	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37849237
85	Oocyte meiosis_Homo sapiens_hsa04114	0.37329990
86	Retinol metabolism_Homo sapiens_hsa00830	0.36690916
87	Vibrio cholerae infection_Homo sapiens_hsa05110	0.36603963
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36398634
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35182205
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33561779
91	p53 signaling pathway_Homo sapiens_hsa04115	0.33555441
92	Viral myocarditis_Homo sapiens_hsa05416	0.31604602
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.30199696
94	Salivary secretion_Homo sapiens_hsa04970	0.29585111
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.29029645
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.28707741
97	TNF signaling pathway_Homo sapiens_hsa04668	0.27178135
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.26855685
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.26397196
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23806899

EIF4A2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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