EIF4A2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter catabolic process (GO:0042135)7.67276978
2peptidyl-arginine omega-N-methylation (GO:0035247)5.94097752
3peptidyl-arginine methylation (GO:0018216)5.69159679
4peptidyl-arginine N-methylation (GO:0035246)5.69159679
5embryonic retina morphogenesis in camera-type eye (GO:0060059)4.98259014
6cerebellar Purkinje cell differentiation (GO:0021702)4.89455706
7somite rostral/caudal axis specification (GO:0032525)4.83536007
8negative regulation of cAMP-mediated signaling (GO:0043951)4.78389940
9S-adenosylmethionine metabolic process (GO:0046500)4.71440463
10granulocyte differentiation (GO:0030851)4.70293931
11cerebellum development (GO:0021549)4.70045316
12primitive streak formation (GO:0090009)4.69022158
13urogenital system development (GO:0001655)4.62151186
14positive regulation of gastrulation (GO:2000543)4.55611171
15long term synaptic depression (GO:0060292)4.48394809
16forebrain neuron development (GO:0021884)4.48089630
17histone arginine methylation (GO:0034969)4.40374327
18regulation of hexokinase activity (GO:1903299)4.33022054
19regulation of glucokinase activity (GO:0033131)4.33022054
20spinal cord association neuron differentiation (GO:0021527)4.30086278
21behavioral response to nicotine (GO:0035095)4.19070888
22thalamus development (GO:0021794)4.13406256
23negative regulation of calcium ion transport into cytosol (GO:0010523)3.95735744
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80231562
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80231562
26retina layer formation (GO:0010842)3.79106129
27bone trabecula formation (GO:0060346)3.71232819
28regulation of germinal center formation (GO:0002634)3.62593321
29positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.58328628
30DNA deamination (GO:0045006)3.53920540
31regulation of hippo signaling (GO:0035330)3.49537553
32neurotransmitter metabolic process (GO:0042133)3.47071283
33head development (GO:0060322)3.43671569
34regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.42683650
35branched-chain amino acid catabolic process (GO:0009083)3.41252444
36peptidyl-arginine modification (GO:0018195)3.39121908
37megakaryocyte development (GO:0035855)3.37660518
38hematopoietic stem cell proliferation (GO:0071425)3.37552869
39phosphatidylserine metabolic process (GO:0006658)3.34398869
40magnesium ion transport (GO:0015693)3.30225649
41hydrogen peroxide biosynthetic process (GO:0050665)3.28695925
42glomerulus development (GO:0032835)3.22450686
43protein prenylation (GO:0018342)3.21941206
44prenylation (GO:0097354)3.21941206
45phosphatidylserine acyl-chain remodeling (GO:0036150)3.21734255
46piRNA metabolic process (GO:0034587)3.19688307
47endoderm formation (GO:0001706)3.17853216
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16880626
49phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16682500
50positive regulation of glycolytic process (GO:0045821)3.16243537
51pattern specification involved in kidney development (GO:0061004)2.93301833
52regulation of meiosis I (GO:0060631)2.93095953
53uterus development (GO:0060065)2.85967037
54reactive oxygen species biosynthetic process (GO:1903409)2.85122340
55amine catabolic process (GO:0009310)2.77399041
56cellular biogenic amine catabolic process (GO:0042402)2.77399041
57regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76958573
58cell differentiation in hindbrain (GO:0021533)2.76477048
59L-methionine salvage (GO:0071267)2.72827214
60L-methionine biosynthetic process (GO:0071265)2.72827214
61amino acid salvage (GO:0043102)2.72827214
62regulation of interferon-beta biosynthetic process (GO:0045357)2.69887551
63central nervous system neuron development (GO:0021954)2.69449876
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.68087108
65negative regulation of telomere maintenance (GO:0032205)2.67597973
66branched-chain amino acid metabolic process (GO:0009081)2.67010046
67establishment of protein localization to vacuole (GO:0072666)2.63106095
68protein targeting to vacuole (GO:0006623)2.63106095
69protein targeting to lysosome (GO:0006622)2.63106095
70vagina development (GO:0060068)2.63070385
71positive regulation of interleukin-12 production (GO:0032735)2.62728085
72regulation of interferon-gamma biosynthetic process (GO:0045072)2.61617322
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61224601
74alditol phosphate metabolic process (GO:0052646)2.61008880
75positive regulation of protein homooligomerization (GO:0032464)2.60277288
76regulation of Rac protein signal transduction (GO:0035020)2.59920885
77chemosensory behavior (GO:0007635)2.58967387
78poly(A)+ mRNA export from nucleus (GO:0016973)2.57277486
79positive regulation of antigen processing and presentation (GO:0002579)2.56898293
80neutrophil activation involved in immune response (GO:0002283)2.56242581
81definitive hemopoiesis (GO:0060216)2.56190198
82adult feeding behavior (GO:0008343)2.55517452
83mitochondrial calcium ion homeostasis (GO:0051560)2.54951948
84protein K11-linked deubiquitination (GO:0035871)2.53968293
85chaperone mediated protein folding requiring cofactor (GO:0051085)2.53504390
86cytochrome complex assembly (GO:0017004)2.53336224
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.53331117
88regulation of metalloenzyme activity (GO:0048552)2.52537980
89phospholipid catabolic process (GO:0009395)2.50139138
90serotonin receptor signaling pathway (GO:0007210)2.49071755
91cell differentiation in spinal cord (GO:0021515)2.48824815
92membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.48649865
93positive regulation of DNA recombination (GO:0045911)2.48055914
94B cell receptor signaling pathway (GO:0050853)2.47590844
95rRNA modification (GO:0000154)2.45648886
96negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.44005113
97positive regulation of interferon-alpha production (GO:0032727)2.43406979
98positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.42621958
99inositol phosphate catabolic process (GO:0071545)2.41241672
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.41047145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.04704282
2IGF1R_20145208_ChIP-Seq_DFB_Human3.59202138
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.84903626
4ZNF274_21170338_ChIP-Seq_K562_Hela2.73163831
5VDR_22108803_ChIP-Seq_LS180_Human2.60494555
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.56792588
7GATA1_22025678_ChIP-Seq_K562_Human2.54566845
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27829965
9GBX2_23144817_ChIP-Seq_PC3_Human2.27389185
10EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.27182624
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22595598
12EWS_26573619_Chip-Seq_HEK293_Human2.17820097
13TAF15_26573619_Chip-Seq_HEK293_Human2.13973081
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06528517
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05860868
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04754614
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91684768
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91388782
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.83897782
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82810314
21GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.79417700
22ER_23166858_ChIP-Seq_MCF-7_Human1.60306326
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53534888
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52479704
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.51363819
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51203363
27FUS_26573619_Chip-Seq_HEK293_Human1.49040776
28VDR_23849224_ChIP-Seq_CD4+_Human1.47829720
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.46677024
30ELK1_19687146_ChIP-ChIP_HELA_Human1.46075268
31TP53_22573176_ChIP-Seq_HFKS_Human1.43507709
32AR_20517297_ChIP-Seq_VCAP_Human1.41546443
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.41338540
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.39903781
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.38839313
36MYC_18940864_ChIP-ChIP_HL60_Human1.38610878
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36186067
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.35478739
39NANOG_19829295_ChIP-Seq_ESCs_Human1.30320039
40SOX2_19829295_ChIP-Seq_ESCs_Human1.30320039
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29470058
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28829543
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27683416
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27329039
45NCOR_22424771_ChIP-Seq_293T_Human1.24625555
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23860384
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21833449
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.21461230
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21051474
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.21051474
51CBP_20019798_ChIP-Seq_JUKART_Human1.18762697
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18762697
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18122745
54REST_21632747_ChIP-Seq_MESCs_Mouse1.17089055
55GATA3_26560356_Chip-Seq_TH2_Human1.16552368
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14950320
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14922921
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14364469
59BCAT_22108803_ChIP-Seq_LS180_Human1.14022057
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13554747
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.12823380
62STAT3_23295773_ChIP-Seq_U87_Human1.12811497
63IRF1_19129219_ChIP-ChIP_H3396_Human1.12202596
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11377808
65TCF4_23295773_ChIP-Seq_U87_Human1.10279369
66CDX2_22108803_ChIP-Seq_LS180_Human1.09681552
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09330279
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08957435
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08785122
70P300_19829295_ChIP-Seq_ESCs_Human1.08662179
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08051123
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07410056
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06966265
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.06356951
75AR_25329375_ChIP-Seq_VCAP_Human1.06131058
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05087394
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04619019
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02777031
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02364278
80TAF2_19829295_ChIP-Seq_ESCs_Human1.01581114
81HTT_18923047_ChIP-ChIP_STHdh_Human1.00820192
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.00747682
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00704395
84TCF4_22108803_ChIP-Seq_LS180_Human1.00423315
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98890529
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98541003
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98301158
88HOXB7_26014856_ChIP-Seq_BT474_Human0.98198303
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.98014827
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96583067
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96380124
92FOXP3_21729870_ChIP-Seq_TREG_Human0.95335093
93RUNX2_22187159_ChIP-Seq_PCA_Human0.94231753
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94230538
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93903635
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93476753
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92110420
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90964910
99STAT1_17558387_ChIP-Seq_HELA_Human0.90699583
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90191492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.53687568
2MP0005645_abnormal_hypothalamus_physiol3.79045282
3MP0003195_calcinosis3.55812481
4MP0002837_dystrophic_cardiac_calcinosis3.35864248
5MP0003172_abnormal_lysosome_physiology2.89015766
6MP0003787_abnormal_imprinting2.56825738
7MP0005646_abnormal_pituitary_gland2.42015252
8MP0003890_abnormal_embryonic-extraembry2.24536134
9MP0002138_abnormal_hepatobiliary_system2.10747881
10MP0003880_abnormal_central_pattern2.10047041
11MP0001764_abnormal_homeostasis2.08356662
12MP0008877_abnormal_DNA_methylation2.01682199
13MP0006276_abnormal_autonomic_nervous1.97716787
14MP0005387_immune_system_phenotype1.83731814
15MP0001790_abnormal_immune_system1.83731814
16MP0002184_abnormal_innervation1.74617725
17MP0001188_hyperpigmentation1.73240051
18MP0008775_abnormal_heart_ventricle1.73063728
19MP0009384_cardiac_valve_regurgitation1.66345584
20MP0000538_abnormal_urinary_bladder1.59305371
21MP0005084_abnormal_gallbladder_morpholo1.58464641
22MP0004043_abnormal_pH_regulation1.54653046
23MP0008875_abnormal_xenobiotic_pharmacok1.53512820
24MP0003718_maternal_effect1.51876676
25MP0006138_congestive_heart_failure1.50587071
26MP0003724_increased_susceptibility_to1.49290328
27MP0001800_abnormal_humoral_immune1.48123760
28MP0002148_abnormal_hypersensitivity_rea1.43101836
29MP0001879_abnormal_lymphatic_vessel1.35746425
30MP0005248_abnormal_Harderian_gland1.35418594
31MP0001849_ear_inflammation1.31836577
32MP0004084_abnormal_cardiac_muscle1.26902069
33MP0005551_abnormal_eye_electrophysiolog1.23216301
34MP0001968_abnormal_touch/_nociception1.21569356
35MP0000015_abnormal_ear_pigmentation1.18017116
36MP0001986_abnormal_taste_sensitivity1.14682582
37MP0003123_paternal_imprinting1.14020703
38MP0004484_altered_response_of1.13949481
39MP0001502_abnormal_circadian_rhythm1.12514141
40MP0002452_abnormal_antigen_presenting1.12150587
41MP0006036_abnormal_mitochondrial_physio1.11470768
42MP0002876_abnormal_thyroid_physiology1.10313055
43MP0004133_heterotaxia1.09847226
44MP0002127_abnormal_cardiovascular_syste1.09678659
45MP0006035_abnormal_mitochondrial_morpho1.09625489
46MP0008872_abnormal_physiological_respon1.08106944
47MP0001835_abnormal_antigen_presentation1.06981687
48MP0003136_yellow_coat_color1.06428766
49MP0003137_abnormal_impulse_conducting1.02659809
50MP0005174_abnormal_tail_pigmentation1.02210580
51MP0005075_abnormal_melanosome_morpholog1.01353340
52MP0000689_abnormal_spleen_morphology0.99391564
53MP0003186_abnormal_redox_activity0.99383689
54MP0002723_abnormal_immune_serum0.98081882
55MP0006072_abnormal_retinal_apoptosis0.97363630
56MP0001905_abnormal_dopamine_level0.96437487
57MP0005058_abnormal_lysosome_morphology0.96065774
58MP0000013_abnormal_adipose_tissue0.95857311
59MP0001501_abnormal_sleep_pattern0.95395129
60MP0002229_neurodegeneration0.94889396
61MP0004085_abnormal_heartbeat0.94860875
62MP0002877_abnormal_melanocyte_morpholog0.91204018
63MP0001944_abnormal_pancreas_morphology0.90855314
64MP0003638_abnormal_response/metabolism_0.90319425
65MP0005332_abnormal_amino_acid0.90260927
66MP0002272_abnormal_nervous_system0.89602469
67MP0002693_abnormal_pancreas_physiology0.89414293
68MP0000049_abnormal_middle_ear0.88033474
69MP0002420_abnormal_adaptive_immunity0.87855131
70MP0009745_abnormal_behavioral_response0.86356696
71MP0001819_abnormal_immune_cell0.86156825
72MP0003075_altered_response_to0.85100218
73MP0005257_abnormal_intraocular_pressure0.83061789
74MP0001293_anophthalmia0.80799279
75MP0001984_abnormal_olfaction0.79318909
76MP0005671_abnormal_response_to0.78545597
77MP0004215_abnormal_myocardial_fiber0.77327585
78MP0010329_abnormal_lipoprotein_level0.76049416
79MP0008995_early_reproductive_senescence0.76031562
80MP0002557_abnormal_social/conspecific_i0.74837575
81MP0005448_abnormal_energy_balance0.72516698
82MP0002095_abnormal_skin_pigmentation0.72257137
83MP0002572_abnormal_emotion/affect_behav0.72242535
84MP0008789_abnormal_olfactory_epithelium0.71958291
85MP0000955_abnormal_spinal_cord0.71086012
86MP0008873_increased_physiological_sensi0.69756210
87MP0000026_abnormal_inner_ear0.69570186
88MP0002733_abnormal_thermal_nociception0.69309502
89MP0005253_abnormal_eye_physiology0.67238963
90MP0005379_endocrine/exocrine_gland_phen0.66581535
91MP0002160_abnormal_reproductive_system0.64619626
92MP0000358_abnormal_cell_content/0.63630338
93MP0004147_increased_porphyrin_level0.62865126
94MP0002102_abnormal_ear_morphology0.62833578
95MP0002139_abnormal_hepatobiliary_system0.61941084
96MP0002210_abnormal_sex_determination0.59686268
97MP0009697_abnormal_copulation0.59148188
98MP0002909_abnormal_adrenal_gland0.59103371
99MP0003959_abnormal_lean_body0.58706812
100MP0005166_decreased_susceptibility_to0.58618592

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.58319311
2Abnormal pancreas size (HP:0012094)4.74797893
3Increased serum pyruvate (HP:0003542)4.42498797
4Renal cortical cysts (HP:0000803)4.00037624
5Stomatitis (HP:0010280)3.99148118
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.90878029
7Abnormality of alanine metabolism (HP:0010916)3.90878029
8Hyperalaninemia (HP:0003348)3.90878029
9Alveolar cell carcinoma (HP:0006519)3.84536248
10Abnormality of glycolysis (HP:0004366)3.79305439
11Methylmalonic acidemia (HP:0002912)3.68533216
12Neoplasm of the tracheobronchial system (HP:0100552)3.50867199
13Cervical subluxation (HP:0003308)3.49806662
14J-shaped sella turcica (HP:0002680)3.43869743
15Abnormality of the renal cortex (HP:0011035)3.13616293
16Hypoplasia of the odontoid process (HP:0003311)3.11914171
17Cerebral palsy (HP:0100021)3.11864690
18Asplenia (HP:0001746)3.07675273
19Aplasia/Hypoplasia of the spleen (HP:0010451)3.04397201
20Chronic sinusitis (HP:0011109)2.99517359
21Decreased circulating renin level (HP:0003351)2.92187050
22Hyperglycinemia (HP:0002154)2.90730124
23Nephronophthisis (HP:0000090)2.79182323
24Mucopolysacchariduria (HP:0008155)2.78394370
25Urinary glycosaminoglycan excretion (HP:0003541)2.78394370
26Methylmalonic aciduria (HP:0012120)2.74278568
27Recurrent pneumonia (HP:0006532)2.68349697
28Shawl scrotum (HP:0000049)2.68149925
29Recurrent bronchitis (HP:0002837)2.63553416
30Elevated erythrocyte sedimentation rate (HP:0003565)2.61802608
31Disproportionate short-trunk short stature (HP:0003521)2.60694275
32Cellulitis (HP:0100658)2.53701104
33Abnormality of polysaccharide metabolism (HP:0011012)2.52528044
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52528044
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52528044
36Large eyes (HP:0001090)2.49157159
37Progressive microcephaly (HP:0000253)2.48193546
38Abnormality of the odontoid process (HP:0003310)2.46776585
39Biliary tract neoplasm (HP:0100574)2.42718527
40Congenital stationary night blindness (HP:0007642)2.40378479
41Type 2 muscle fiber atrophy (HP:0003554)2.34403223
42Gaze-evoked nystagmus (HP:0000640)2.33364701
43Abnormality of vitamin B metabolism (HP:0004340)2.24486759
44Abnormal drinking behavior (HP:0030082)2.22582682
45Polydipsia (HP:0001959)2.22582682
46Eczematoid dermatitis (HP:0000976)2.21655743
47Midline defect of the nose (HP:0004122)2.20078292
48Abnormality of the renal medulla (HP:0100957)2.18611337
49Panhypogammaglobulinemia (HP:0003139)2.17424284
50Abnormality of midbrain morphology (HP:0002418)2.14483772
51Molar tooth sign on MRI (HP:0002419)2.14483772
52Tongue fasciculations (HP:0001308)2.14453366
53Attenuation of retinal blood vessels (HP:0007843)2.13459861
54Type I diabetes mellitus (HP:0100651)2.12803961
55Villous atrophy (HP:0011473)2.08116131
56Abnormality of small intestinal villus morphology (HP:0011472)2.08116131
57Meningitis (HP:0001287)2.07856603
58IgG deficiency (HP:0004315)2.06885556
59Reduced antithrombin III activity (HP:0001976)2.06016022
60Joint stiffness (HP:0001387)2.05142070
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.04698724
62Pancreatic cysts (HP:0001737)2.03074192
63Abnormality of renin-angiotensin system (HP:0000847)2.02124582
64Spinal canal stenosis (HP:0003416)2.00861616
65Enlarged kidneys (HP:0000105)2.00286626
66Hypomagnesemia (HP:0002917)2.00216466
67Recurrent fungal infections (HP:0002841)1.99870980
68Failure to thrive in infancy (HP:0001531)1.95598655
69Type I transferrin isoform profile (HP:0003642)1.93549616
70Breast carcinoma (HP:0003002)1.92666154
71Flared iliac wings (HP:0002869)1.88902334
72Pancreatic fibrosis (HP:0100732)1.87895433
73Abnormality of serum amino acid levels (HP:0003112)1.87460631
74Severe muscular hypotonia (HP:0006829)1.85231235
75Dicarboxylic aciduria (HP:0003215)1.85118540
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85118540
77Abnormality of macrophages (HP:0004311)1.84118662
78Abnormality of the prostate (HP:0008775)1.84037989
79Medial flaring of the eyebrow (HP:0010747)1.81553681
80Recurrent lower respiratory tract infections (HP:0002783)1.79545737
81Papilloma (HP:0012740)1.79226146
82Verrucae (HP:0200043)1.79226146
83Chronic mucocutaneous candidiasis (HP:0002728)1.77645264
84Recurrent cutaneous fungal infections (HP:0011370)1.77645264
85Abnormality of serine family amino acid metabolism (HP:0010894)1.76793144
86Abnormality of glycine metabolism (HP:0010895)1.76793144
87Constricted visual fields (HP:0001133)1.76204442
88Metabolic alkalosis (HP:0200114)1.74836801
89Tetany (HP:0001281)1.73331401
90Curly hair (HP:0002212)1.73223637
91Osteomyelitis (HP:0002754)1.72343337
92Muscle fiber atrophy (HP:0100295)1.71076901
93Muscle fibrillation (HP:0010546)1.68243167
94Abnormality of the sella turcica (HP:0002679)1.67552098
95Central scotoma (HP:0000603)1.66390184
96Optic nerve hypoplasia (HP:0000609)1.65908465
97Hemiparesis (HP:0001269)1.65263926
98Abnormal biliary tract morphology (HP:0012440)1.63740723
99Ketoacidosis (HP:0001993)1.63434174
100Polyuria (HP:0000103)1.62286285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.95239303
2FRK3.92157719
3MST43.78006137
4MKNK13.24165756
5IRAK43.13686151
6ADRBK22.88458277
7MAP3K42.54600508
8MAPKAPK52.30484882
9BCKDK2.25877450
10TAOK32.22553617
11MAP4K22.12025840
12IKBKB2.04749329
13DAPK22.00942741
14WNK31.90631751
15TLK11.84100100
16TNK21.81967559
17RPS6KA41.80065311
18NTRK21.64813826
19BMPR21.61262007
20PKN11.49248641
21NUAK11.44289589
22RPS6KA51.41008994
23GRK61.39695471
24MAPK131.38145752
25EPHA31.37370425
26GRK11.30268537
27TRIM281.29775168
28STK391.29688441
29TXK1.24807020
30NME21.21113126
31CHUK1.16906341
32TAOK11.15131526
33KIT1.14176877
34BMPR1B1.11969890
35PRKCE1.10562606
36FES1.06436393
37MAP3K21.03677558
38WNK41.01893655
39MUSK1.01677799
40BRD40.99982171
41NEK60.99488296
42PRKCQ0.95035892
43ZAK0.94969167
44TBK10.91016282
45PRKD10.90243473
46FGFR20.90115654
47TAF10.86127360
48FER0.83634235
49MAP2K10.83554249
50ADRBK10.82225032
51CAMKK20.81903223
52SYK0.80240819
53EIF2AK30.78814575
54MAP2K70.76872150
55DAPK30.76400720
56FLT30.75411240
57LYN0.74559500
58LIMK10.72366982
59IKBKE0.71995459
60MAP3K140.70956890
61DAPK10.70589818
62OXSR10.69364468
63MKNK20.69320384
64STK380.66353731
65CAMK2D0.65221536
66PRKCI0.62372413
67CSNK1G30.60110062
68FGFR30.59279817
69CAMK2A0.56965120
70PIK3CA0.56582712
71TEC0.56538788
72PAK30.55998905
73CDK70.54926365
74VRK10.52944918
75PRKCZ0.51468547
76PRKD20.51071534
77TAOK20.50712325
78PLK40.50447543
79CSNK1A1L0.49777125
80EPHA20.48830888
81CSNK1G20.47777954
82ITK0.46663163
83TYK20.46447385
84CAMK2G0.44904602
85LCK0.43648784
86CAMK2B0.43330064
87PRKCG0.41832326
88BRSK20.40486807
89JAK10.40014897
90WNK10.39251355
91HIPK20.37107881
92TSSK60.36909767
93TIE10.34286728
94PHKG10.34101494
95PHKG20.34101494
96BTK0.32791926
97ACVR1B0.32295748
98MAPK110.32150913
99PTK2B0.29339368
100CSNK1G10.28542973

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.40997670
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09573238
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.98724197
4Type I diabetes mellitus_Homo sapiens_hsa049402.81332160
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.70947896
6Primary immunodeficiency_Homo sapiens_hsa053402.70045718
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.60532054
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42660724
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38552851
10Allograft rejection_Homo sapiens_hsa053302.35749543
11Linoleic acid metabolism_Homo sapiens_hsa005912.33426898
12Autoimmune thyroid disease_Homo sapiens_hsa053202.21822636
13Propanoate metabolism_Homo sapiens_hsa006402.10628329
14Butanoate metabolism_Homo sapiens_hsa006502.09185591
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97651298
16Graft-versus-host disease_Homo sapiens_hsa053321.94934613
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.94795039
18Basal transcription factors_Homo sapiens_hsa030221.92688117
19Antigen processing and presentation_Homo sapiens_hsa046121.67842256
20Insulin secretion_Homo sapiens_hsa049111.60566990
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.59810158
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58193531
23Peroxisome_Homo sapiens_hsa041461.53494181
24B cell receptor signaling pathway_Homo sapiens_hsa046621.45822892
25Ether lipid metabolism_Homo sapiens_hsa005651.45745409
26Regulation of autophagy_Homo sapiens_hsa041401.44678567
27Ovarian steroidogenesis_Homo sapiens_hsa049131.43930150
28Rheumatoid arthritis_Homo sapiens_hsa053231.42557947
29Selenocompound metabolism_Homo sapiens_hsa004501.37172029
30Collecting duct acid secretion_Homo sapiens_hsa049661.35871510
31Arachidonic acid metabolism_Homo sapiens_hsa005901.33579944
32RNA degradation_Homo sapiens_hsa030181.30245366
33Long-term depression_Homo sapiens_hsa047301.29353754
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22585992
35Non-homologous end-joining_Homo sapiens_hsa034501.19688291
36Malaria_Homo sapiens_hsa051441.16919345
37Caffeine metabolism_Homo sapiens_hsa002321.12604431
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08846578
39Phototransduction_Homo sapiens_hsa047441.01060522
40Serotonergic synapse_Homo sapiens_hsa047260.99640467
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.98967385
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97090675
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95296579
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93823658
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93790087
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93681251
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93676046
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89868977
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88264112
50Chemical carcinogenesis_Homo sapiens_hsa052040.81210360
51Staphylococcus aureus infection_Homo sapiens_hsa051500.79359447
52Taste transduction_Homo sapiens_hsa047420.75193669
53Mineral absorption_Homo sapiens_hsa049780.75036418
54Proteasome_Homo sapiens_hsa030500.73801971
55Salivary secretion_Homo sapiens_hsa049700.71536288
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69418808
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69336095
58Circadian entrainment_Homo sapiens_hsa047130.68690180
59Type II diabetes mellitus_Homo sapiens_hsa049300.64532973
60Synaptic vesicle cycle_Homo sapiens_hsa047210.64402512
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61286370
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.60565546
63Nitrogen metabolism_Homo sapiens_hsa009100.58640034
64Lysosome_Homo sapiens_hsa041420.58558244
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58504150
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.56259134
67Circadian rhythm_Homo sapiens_hsa047100.56024961
68Hematopoietic cell lineage_Homo sapiens_hsa046400.54820813
69Viral myocarditis_Homo sapiens_hsa054160.53654195
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52615456
71RNA polymerase_Homo sapiens_hsa030200.51259670
72Retinol metabolism_Homo sapiens_hsa008300.51093982
73Tuberculosis_Homo sapiens_hsa051520.46927166
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45919968
75Renin secretion_Homo sapiens_hsa049240.45311525
76Oxytocin signaling pathway_Homo sapiens_hsa049210.43832267
77Homologous recombination_Homo sapiens_hsa034400.43808569
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43776984
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42957759
80Sulfur metabolism_Homo sapiens_hsa009200.42880177
81Oxidative phosphorylation_Homo sapiens_hsa001900.42524589
82Olfactory transduction_Homo sapiens_hsa047400.42303715
83Fanconi anemia pathway_Homo sapiens_hsa034600.42004028
84Sulfur relay system_Homo sapiens_hsa041220.38168305
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36957283
86African trypanosomiasis_Homo sapiens_hsa051430.36800693
87Glutamatergic synapse_Homo sapiens_hsa047240.36234353
88Protein export_Homo sapiens_hsa030600.35646163
89Pancreatic secretion_Homo sapiens_hsa049720.35014667
90Cardiac muscle contraction_Homo sapiens_hsa042600.34937049
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34166958
92Dorso-ventral axis formation_Homo sapiens_hsa043200.32760615
93ABC transporters_Homo sapiens_hsa020100.32189100
94Metabolic pathways_Homo sapiens_hsa011000.32098213
95RNA transport_Homo sapiens_hsa030130.31066532
96Phagosome_Homo sapiens_hsa041450.31030541
97Leishmaniasis_Homo sapiens_hsa051400.30924669
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30453574
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28493644
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28340341

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