ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	preassembly of GPI anchor in ER membrane (GO:0016254)	6.12248655
2	regulation of regulatory T cell differentiation (GO:0045589)	6.09815391
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.88508954
4	cell wall macromolecule catabolic process (GO:0016998)	5.37466345
5	regulation of immunoglobulin secretion (GO:0051023)	5.28357994
6	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.22845400
7	mannosylation (GO:0097502)	4.97991246
8	regulation of isotype switching to IgG isotypes (GO:0048302)	4.87911723
9	cell wall macromolecule metabolic process (GO:0044036)	4.41726245
10	regulation of RIG-I signaling pathway (GO:0039535)	4.34572121
11	GPI anchor biosynthetic process (GO:0006506)	4.32178336
12	C-terminal protein lipidation (GO:0006501)	4.31469376
13	GPI anchor metabolic process (GO:0006505)	4.18917670
14	C-terminal protein amino acid modification (GO:0018410)	4.17295058
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.09716420
16	DNA deamination (GO:0045006)	4.08272877
17	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	4.08136496
18	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.93241368
19	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.93241368
20	isotype switching (GO:0045190)	3.93241368
21	regulation of protein polyubiquitination (GO:1902914)	3.80208248
22	righting reflex (GO:0060013)	3.77372591
23	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.73514370
24	L-fucose catabolic process (GO:0042355)	3.71915098
25	fucose catabolic process (GO:0019317)	3.71915098
26	L-fucose metabolic process (GO:0042354)	3.71915098
27	response to gravity (GO:0009629)	3.68109764
28	adult feeding behavior (GO:0008343)	3.51017398
29	regulation of chronic inflammatory response (GO:0002676)	3.49846400
30	NIK/NF-kappaB signaling (GO:0038061)	3.48983808
31	respiratory chain complex IV assembly (GO:0008535)	3.44987992
32	tolerance induction (GO:0002507)	3.44615333
33	positive regulation of interleukin-17 production (GO:0032740)	3.41038977
34	regulation of B cell apoptotic process (GO:0002902)	3.40453859
35	behavioral response to ethanol (GO:0048149)	3.38483023
36	ubiquinone biosynthetic process (GO:0006744)	3.33346206
37	cytochrome complex assembly (GO:0017004)	3.30493523
38	negative regulation of B cell apoptotic process (GO:0002903)	3.28469396
39	signal peptide processing (GO:0006465)	3.22028067
40	positive regulation of defense response to virus by host (GO:0002230)	3.19190090
41	necroptotic process (GO:0070266)	3.17299545
42	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.17046806
43	behavioral response to nicotine (GO:0035095)	3.12272294
44	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.11690655
45	inositol phosphate dephosphorylation (GO:0046855)	3.11690655
46	ubiquinone metabolic process (GO:0006743)	3.09458279
47	endocrine pancreas development (GO:0031018)	3.07628892
48	protein polyglutamylation (GO:0018095)	3.05842051
49	neural tube formation (GO:0001841)	3.05719199
50	inositol phosphate catabolic process (GO:0071545)	3.05657352
51	cornea development in camera-type eye (GO:0061303)	2.96780672
52	positive regulation of isotype switching (GO:0045830)	2.96292773
53	kynurenine metabolic process (GO:0070189)	2.96235739
54	reflex (GO:0060004)	2.95477759
55	prenylation (GO:0097354)	2.91946745
56	protein prenylation (GO:0018342)	2.91946745
57	protein-cofactor linkage (GO:0018065)	2.89798107
58	water-soluble vitamin biosynthetic process (GO:0042364)	2.89141559
59	detection of light stimulus involved in sensory perception (GO:0050962)	2.87914151
60	detection of light stimulus involved in visual perception (GO:0050908)	2.87914151
61	transcription from mitochondrial promoter (GO:0006390)	2.85867783
62	glycolipid biosynthetic process (GO:0009247)	2.83618445
63	amino acid salvage (GO:0043102)	2.82617863
64	L-methionine salvage (GO:0071267)	2.82617863
65	L-methionine biosynthetic process (GO:0071265)	2.82617863
66	positive regulation of DNA recombination (GO:0045911)	2.80088203
67	proline transport (GO:0015824)	2.79929948
68	cellular ketone body metabolic process (GO:0046950)	2.77657488
69	regulation of mitotic spindle checkpoint (GO:1903504)	2.77629514
70	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.77629514
71	quinone biosynthetic process (GO:1901663)	2.77496592
72	rRNA modification (GO:0000154)	2.76989712
73	alternative mRNA splicing, via spliceosome (GO:0000380)	2.76346521
74	estrogen biosynthetic process (GO:0006703)	2.75047451
75	negative regulation of acute inflammatory response (GO:0002674)	2.74581578
76	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.74061603
77	rRNA methylation (GO:0031167)	2.71022706
78	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.70466384
79	positive regulation of B cell mediated immunity (GO:0002714)	2.69626598
80	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.69626598
81	protein neddylation (GO:0045116)	2.67153243
82	negative regulation of protein oligomerization (GO:0032460)	2.65028918
83	regulation of memory T cell differentiation (GO:0043380)	2.64822819
84	somite development (GO:0061053)	2.61629906
85	mitotic cell cycle arrest (GO:0071850)	2.61396352
86	positive regulation of glycolytic process (GO:0045821)	2.59001489
87	cellular response to ATP (GO:0071318)	2.56193658
88	protein complex biogenesis (GO:0070271)	2.55727854
89	indole-containing compound catabolic process (GO:0042436)	2.53785652
90	indolalkylamine catabolic process (GO:0046218)	2.53785652
91	tryptophan catabolic process (GO:0006569)	2.53785652
92	nitric oxide mediated signal transduction (GO:0007263)	2.53607823
93	regulation of glucokinase activity (GO:0033131)	2.52480183
94	regulation of hexokinase activity (GO:1903299)	2.52480183
95	lactate metabolic process (GO:0006089)	2.52017253
96	cellular response to exogenous dsRNA (GO:0071360)	2.51890555
97	zinc ion homeostasis (GO:0055069)	2.51791190
98	regulation of T cell receptor signaling pathway (GO:0050856)	2.50836765
99	xenobiotic catabolic process (GO:0042178)	2.50283854
100	B cell activation involved in immune response (GO:0002312)	2.49957774

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.62348176
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60450434
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.51218172
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.47520077
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.14228302
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.82820975
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.68330145
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.57186816
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.43146729
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39575254
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23999861
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19455541
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.17745850
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.16192570
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11812739
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.11542203
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.04713762
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04516098
19	FUS_26573619_Chip-Seq_HEK293_Human	2.03316409
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01304493
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00111611
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.95436633
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83108211
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82818370
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82550937
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77497841
27	EWS_26573619_Chip-Seq_HEK293_Human	1.75593437
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74618854
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73677678
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69632220
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67022727
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.66595801
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.64779664
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.63802547
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.62763508
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.61249467
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58434480
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55668660
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52901993
40	P300_19829295_ChIP-Seq_ESCs_Human	1.52813132
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52394026
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.50570140
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.50570140
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50560047
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50255260
46	AR_20517297_ChIP-Seq_VCAP_Human	1.48354361
47	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.46791794
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.46140858
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45278792
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45278792
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.42860581
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41773635
53	GATA3_26560356_Chip-Seq_TH2_Human	1.41229830
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38417491
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37896255
56	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.35003380
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32646029
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30541146
59	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29402019
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23337297
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21169411
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20627078
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20164118
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19703245
65	HTT_18923047_ChIP-ChIP_STHdh_Human	1.18499910
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.16054399
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16054399
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15087009
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.14135505
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10468147
71	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.10178907
72	GATA3_27048872_Chip-Seq_THYMUS_Human	1.09764668
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08954334
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08182984
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07412665
76	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07240392
77	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06761787
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06720909
79	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.04369075
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04345136
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.04007752
82	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.03603840
83	GATA3_26560356_Chip-Seq_TH1_Human	1.02960347
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02697924
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.02125101
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01457454
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01374766
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01000649
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00922215
90	NCOR_22424771_ChIP-Seq_293T_Human	1.00544386
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98649559
92	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98485170
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98315216
94	STAT1_20625510_ChIP-Seq_HELA_Human	0.97854478
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97343301
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96367892
97	AR_25329375_ChIP-Seq_VCAP_Human	0.95434172
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94302929
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93173513
100	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.92736162

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.17978512
2	MP0003300_gastrointestinal_ulcer	3.39163396
3	MP0006072_abnormal_retinal_apoptosis	3.22131515
4	MP0003191_abnormal_cellular_cholesterol	2.82821650
5	MP0003195_calcinosis	2.73411988
6	MP0002009_preneoplasia	2.62634068
7	MP0005671_abnormal_response_to	2.53363676
8	MP0000372_irregular_coat_pigmentation	2.30416117
9	MP0002837_dystrophic_cardiac_calcinosis	2.29070957
10	MP0008877_abnormal_DNA_methylation	2.21924516
11	MP0001501_abnormal_sleep_pattern	2.08932859
12	MP0005379_endocrine/exocrine_gland_phen	2.05232015
13	MP0008872_abnormal_physiological_respon	2.02488751
14	MP0001835_abnormal_antigen_presentation	1.99092721
15	MP0002166_altered_tumor_susceptibility	1.97379802
16	MP0003718_maternal_effect	1.97330554
17	MP0004270_analgesia	1.97220230
18	MP0002909_abnormal_adrenal_gland	1.94727254
19	MP0003806_abnormal_nucleotide_metabolis	1.91785766
20	MP0002736_abnormal_nociception_after	1.90086660
21	MP0002693_abnormal_pancreas_physiology	1.82625778
22	MP0000465_gastrointestinal_hemorrhage	1.75672841
23	MP0003786_premature_aging	1.68136736
24	MP0005645_abnormal_hypothalamus_physiol	1.66582008
25	MP0005646_abnormal_pituitary_gland	1.65550440
26	MP0001944_abnormal_pancreas_morphology	1.64462849
27	MP0001968_abnormal_touch/_nociception	1.64422541
28	MP0002102_abnormal_ear_morphology	1.64182062
29	MP0000685_abnormal_immune_system	1.63941178
30	MP0002163_abnormal_gland_morphology	1.61254952
31	MP0009046_muscle_twitch	1.60231628
32	MP0000604_amyloidosis	1.59875419
33	MP0002138_abnormal_hepatobiliary_system	1.54884361
34	MP0001661_extended_life_span	1.52745423
35	MP0005551_abnormal_eye_electrophysiolog	1.52099630
36	MP0008775_abnormal_heart_ventricle	1.51800049
37	MP0001986_abnormal_taste_sensitivity	1.50709827
38	MP0006036_abnormal_mitochondrial_physio	1.46339286
39	MP0006035_abnormal_mitochondrial_morpho	1.45830452
40	MP0001905_abnormal_dopamine_level	1.45372461
41	MP0003866_abnormal_defecation	1.45009869
42	MP0004147_increased_porphyrin_level	1.42281897
43	MP0005253_abnormal_eye_physiology	1.40300945
44	MP0006276_abnormal_autonomic_nervous	1.40250194
45	MP0002277_abnormal_respiratory_mucosa	1.33913693
46	MP0002006_tumorigenesis	1.30474986
47	MP0003172_abnormal_lysosome_physiology	1.28991403
48	MP0002148_abnormal_hypersensitivity_rea	1.24871555
49	MP0004782_abnormal_surfactant_physiolog	1.21089591
50	MP0004510_myositis	1.20248088
51	MP0004142_abnormal_muscle_tone	1.18591575
52	MP0009745_abnormal_behavioral_response	1.12007560
53	MP0004924_abnormal_behavior	1.09862982
54	MP0005386_behavior/neurological_phenoty	1.09862982
55	MP0005000_abnormal_immune_tolerance	1.09719519
56	MP0004019_abnormal_vitamin_homeostasis	1.09442392
57	MP0003011_delayed_dark_adaptation	1.06227248
58	MP0005084_abnormal_gallbladder_morpholo	1.04929494
59	MP0009785_altered_susceptibility_to	1.04698372
60	MP0003283_abnormal_digestive_organ	1.04434403
61	MP0005220_abnormal_exocrine_pancreas	1.04367104
62	MP0004145_abnormal_muscle_electrophysio	1.03849144
63	MP0002938_white_spotting	1.01814745
64	MP0003880_abnormal_central_pattern	1.01583346
65	MP0009697_abnormal_copulation	1.00714326
66	MP0002272_abnormal_nervous_system	0.98338510
67	MP0003045_fibrosis	0.97057483
68	MP0005075_abnormal_melanosome_morpholog	0.94832795
69	MP0004885_abnormal_endolymph	0.94212814
70	MP0002928_abnormal_bile_duct	0.93612060
71	MP0003567_abnormal_fetal_cardiomyocyte	0.92717321
72	MP0000516_abnormal_urinary_system	0.90416776
73	MP0005367_renal/urinary_system_phenotyp	0.90416776
74	MP0008875_abnormal_xenobiotic_pharmacok	0.89461697
75	MP0005448_abnormal_energy_balance	0.89456378
76	MP0010155_abnormal_intestine_physiology	0.89149235
77	MP0002751_abnormal_autonomic_nervous	0.87312477
78	MP0005395_other_phenotype	0.83530646
79	MP0003724_increased_susceptibility_to	0.82656385
80	MP0000230_abnormal_systemic_arterial	0.82598165
81	MP0000631_abnormal_neuroendocrine_gland	0.82556137
82	MP0001845_abnormal_inflammatory_respons	0.82512124
83	MP0002723_abnormal_immune_serum	0.82010249
84	MP0010234_abnormal_vibrissa_follicle	0.81834735
85	MP0002733_abnormal_thermal_nociception	0.81795773
86	MP0004484_altered_response_of	0.81614321
87	MP0002876_abnormal_thyroid_physiology	0.81489457
88	MP0001984_abnormal_olfaction	0.81151964
89	MP0009780_abnormal_chondrocyte_physiolo	0.80638930
90	MP0001800_abnormal_humoral_immune	0.80537153
91	MP0002734_abnormal_mechanical_nocicepti	0.79077280
92	MP0003121_genomic_imprinting	0.77562523
93	MP0010329_abnormal_lipoprotein_level	0.77492360
94	MP0005165_increased_susceptibility_to	0.76909336
95	MP0001756_abnormal_urination	0.75265322
96	MP0002184_abnormal_innervation	0.71139984
97	MP0004043_abnormal_pH_regulation	0.70998521
98	MP0002572_abnormal_emotion/affect_behav	0.70614860
99	MP0009643_abnormal_urine_homeostasis	0.70295195
100	MP0004215_abnormal_myocardial_fiber	0.70273697

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.75271279
2	Hypothermia (HP:0002045)	4.19949959
3	Hyperglycemia (HP:0003074)	3.83523625
4	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.70189202
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.70189202
6	IgG deficiency (HP:0004315)	3.53386791
7	Ketoacidosis (HP:0001993)	3.46579221
8	Pancreatic cysts (HP:0001737)	3.14645944
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07713969
10	Progressive macrocephaly (HP:0004481)	3.02110580
11	Insulin-resistant diabetes mellitus (HP:0000831)	2.98528084
12	Acute necrotizing encephalopathy (HP:0006965)	2.94661420
13	Thyroiditis (HP:0100646)	2.89798298
14	Type II lissencephaly (HP:0007260)	2.89067754
15	Amniotic constriction ring (HP:0009775)	2.84311566
16	Abnormality of placental membranes (HP:0011409)	2.84311566
17	Cerebral hypomyelination (HP:0006808)	2.77647394
18	Hepatocellular necrosis (HP:0001404)	2.71872634
19	Progressive inability to walk (HP:0002505)	2.71626042
20	Abnormality of midbrain morphology (HP:0002418)	2.66446774
21	Molar tooth sign on MRI (HP:0002419)	2.66446774
22	Hepatic necrosis (HP:0002605)	2.65056923
23	Pancreatic fibrosis (HP:0100732)	2.64466034
24	Abnormality of the renal cortex (HP:0011035)	2.62383173
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.59102114
26	Type 2 muscle fiber atrophy (HP:0003554)	2.58767535
27	Aplasia/hypoplasia of the uterus (HP:0008684)	2.57453715
28	Spastic paraparesis (HP:0002313)	2.54464949
29	Chronic hepatic failure (HP:0100626)	2.52697312
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.48883543
31	Abnormality of the fovea (HP:0000493)	2.45342579
32	Poor speech (HP:0002465)	2.45278166
33	True hermaphroditism (HP:0010459)	2.45200197
34	Congenital stationary night blindness (HP:0007642)	2.41981196
35	Central scotoma (HP:0000603)	2.41001109
36	Abnormality of endocrine pancreas physiology (HP:0012093)	2.36152530
37	Abnormality of the pancreatic islet cells (HP:0006476)	2.36152530
38	Large for gestational age (HP:0001520)	2.35739908
39	Mitochondrial inheritance (HP:0001427)	2.34766646
40	Increased CSF lactate (HP:0002490)	2.34620105
41	Constricted visual fields (HP:0001133)	2.34561449
42	Attenuation of retinal blood vessels (HP:0007843)	2.30386632
43	Late onset (HP:0003584)	2.27646741
44	B lymphocytopenia (HP:0010976)	2.26425645
45	Ketosis (HP:0001946)	2.26305424
46	Acute encephalopathy (HP:0006846)	2.25424076
47	Congenital, generalized hypertrichosis (HP:0004540)	2.22841878
48	Nephronophthisis (HP:0000090)	2.22372898
49	Renal cortical cysts (HP:0000803)	2.22312148
50	3-Methylglutaconic aciduria (HP:0003535)	2.22074182
51	Inability to walk (HP:0002540)	2.21074817
52	Sensory axonal neuropathy (HP:0003390)	2.21073537
53	Abnormality of B cell number (HP:0010975)	2.20307362
54	Severe combined immunodeficiency (HP:0004430)	2.18495414
55	Polydipsia (HP:0001959)	2.16369476
56	Abnormal drinking behavior (HP:0030082)	2.16369476
57	Conical tooth (HP:0000698)	2.15988864
58	Tongue fasciculations (HP:0001308)	2.15531563
59	Scotoma (HP:0000575)	2.14565028
60	Abnormality of the musculature of the pelvis (HP:0001469)	2.13698287
61	Abnormality of the hip-girdle musculature (HP:0001445)	2.13698287
62	Insulin resistance (HP:0000855)	2.12717698
63	Cutaneous melanoma (HP:0012056)	2.11791964
64	Abnormality of T cell physiology (HP:0011840)	2.10557491
65	Hypoplasia of the uterus (HP:0000013)	2.08522469
66	Congenital sensorineural hearing impairment (HP:0008527)	2.07976189
67	Bony spicule pigmentary retinopathy (HP:0007737)	2.07084006
68	Hematochezia (HP:0002573)	2.06255815
69	Medial flaring of the eyebrow (HP:0010747)	2.06025106
70	Palpitations (HP:0001962)	2.05542451
71	Hypoglycemic seizures (HP:0002173)	2.04496419
72	Popliteal pterygium (HP:0009756)	2.03458685
73	Furrowed tongue (HP:0000221)	2.01223462
74	Muscle fiber atrophy (HP:0100295)	2.00027114
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.96789818
76	Hypoglycemic coma (HP:0001325)	1.96650960
77	Abolished electroretinogram (ERG) (HP:0000550)	1.96488669
78	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96483744
79	Poor suck (HP:0002033)	1.95912364
80	Type I diabetes mellitus (HP:0100651)	1.94704508
81	Delayed gross motor development (HP:0002194)	1.94458085
82	Methylmalonic aciduria (HP:0012120)	1.92361084
83	Severe muscular hypotonia (HP:0006829)	1.89654748
84	Methylmalonic acidemia (HP:0002912)	1.89038232
85	Increased serum lactate (HP:0002151)	1.87757625
86	Oligodontia (HP:0000677)	1.86283618
87	Calf muscle hypertrophy (HP:0008981)	1.86122794
88	Retinal dysplasia (HP:0007973)	1.84809399
89	Abnormality of the renal medulla (HP:0100957)	1.83512534
90	Respiratory failure (HP:0002878)	1.83124382
91	Gaze-evoked nystagmus (HP:0000640)	1.82266645
92	Hypsarrhythmia (HP:0002521)	1.82251465
93	Abnormality of vitamin B metabolism (HP:0004340)	1.81434927
94	Pustule (HP:0200039)	1.81342420
95	Lethargy (HP:0001254)	1.80769842
96	Hyperthyroidism (HP:0000836)	1.79634375
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79089245
98	Broad-based gait (HP:0002136)	1.78496995
99	Intention tremor (HP:0002080)	1.77714080
100	Azoospermia (HP:0000027)	1.77553700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.08733461
2	TRIM28	3.18197249
3	TXK	3.10329021
4	MST4	2.83172860
5	SIK3	2.59864812
6	MAP4K2	2.53979669
7	ADRBK2	2.25541408
8	TLK1	2.21524919
9	EIF2AK3	2.11477270
10	MAP3K4	2.10466729
11	PASK	2.08947060
12	EPHA3	1.98106994
13	ERBB3	1.89781377
14	FGFR2	1.88917365
15	WNK3	1.74537841
16	TEC	1.72230899
17	MAP3K12	1.68998229
18	DAPK2	1.68669349
19	PINK1	1.66691171
20	MAPKAPK3	1.53556877
21	PHKG2	1.51985635
22	PHKG1	1.51985635
23	GRK1	1.47802879
24	TSSK6	1.46595570
25	MAP2K7	1.44888729
26	ZAK	1.44232145
27	SIK2	1.42107813
28	NLK	1.41598011
29	MAP3K14	1.41475832
30	NUAK1	1.39462445
31	ITK	1.38495484
32	CASK	1.31672286
33	TRPM7	1.24200800
34	OXSR1	1.21496205
35	IKBKB	1.20049734
36	STK16	1.18787650
37	MAPK13	1.05226461
38	CSNK1G3	1.00895587
39	CSNK1G1	1.00183215
40	MAP2K2	0.96694615
41	CAMKK2	0.96418961
42	MAP2K6	0.94967780
43	BUB1	0.94833108
44	LMTK2	0.94740351
45	STK39	0.93587584
46	WNK4	0.92978524
47	HIPK2	0.91355850
48	GRK6	0.90635917
49	TNIK	0.90033643
50	PLK3	0.88197353
51	BMPR1B	0.83534863
52	PAK3	0.83449892
53	SRPK1	0.80978766
54	JAK1	0.79810782
55	CSNK1G2	0.75034282
56	EIF2AK2	0.73931630
57	IRAK1	0.72025481
58	FGFR3	0.71485779
59	BTK	0.70763046
60	INSRR	0.64701461
61	PLK2	0.63158339
62	TBK1	0.62346435
63	TAOK3	0.61925709
64	DYRK2	0.60341456
65	ALK	0.58930319
66	LIMK1	0.54365193
67	UHMK1	0.54024822
68	PTK2B	0.53607202
69	MAP3K13	0.53353580
70	KDR	0.51434727
71	LCK	0.49071533
72	MYLK	0.47508819
73	LYN	0.45630463
74	DAPK1	0.45136398
75	RPS6KA5	0.44683950
76	YES1	0.44452713
77	IKBKE	0.43909215
78	PRKCQ	0.43472628
79	EGFR	0.43349167
80	ADRBK1	0.42924116
81	PRKCE	0.42883995
82	MAP4K1	0.40326584
83	FER	0.40298161
84	IGF1R	0.39939817
85	MAPK7	0.38407465
86	EPHB1	0.37752598
87	PRKAA1	0.35962060
88	CSNK1A1	0.35234210
89	OBSCN	0.35212190
90	BCR	0.34620372
91	PRKCG	0.33921486
92	CSNK1A1L	0.33889078
93	MKNK1	0.32800718
94	CHUK	0.32449619
95	CSNK2A2	0.31428307
96	BCKDK	0.31276307
97	CAMK2A	0.31157652
98	CDK6	0.30959592
99	VRK1	0.30928057
100	RPS6KB2	0.28293842

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.49867607
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.27777704
3	Protein export_Homo sapiens_hsa03060	3.80406344
4	Type I diabetes mellitus_Homo sapiens_hsa04940	2.73905518
5	Asthma_Homo sapiens_hsa05310	2.66774930
6	Basal transcription factors_Homo sapiens_hsa03022	2.56997772
7	Proteasome_Homo sapiens_hsa03050	2.29184632
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.27930456
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.26780914
10	Allograft rejection_Homo sapiens_hsa05330	2.20443371
11	RNA polymerase_Homo sapiens_hsa03020	2.17254795
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14705701
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.10203922
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98436516
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91599553
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.85981970
17	Butanoate metabolism_Homo sapiens_hsa00650	1.79623542
18	Sulfur metabolism_Homo sapiens_hsa00920	1.69178839
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.68967452
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.67151137
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.60581658
22	Phototransduction_Homo sapiens_hsa04744	1.56595027
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.55126046
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48093162
25	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.46230898
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.37485792
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.36134410
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26794736
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26215874
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23393657
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23114249
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21323183
33	RNA degradation_Homo sapiens_hsa03018	1.21032847
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20867688
35	Propanoate metabolism_Homo sapiens_hsa00640	1.14493460
36	Parkinsons disease_Homo sapiens_hsa05012	1.11831455
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10774900
38	Caffeine metabolism_Homo sapiens_hsa00232	1.07805076
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.06083966
40	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.05787710
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03732786
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03068511
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.02882326
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.00107792
45	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.98379252
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.95780827
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95204589
48	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.94355637
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93489489
50	Homologous recombination_Homo sapiens_hsa03440	0.93292047
51	Fatty acid degradation_Homo sapiens_hsa00071	0.89069310
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88106682
53	Fatty acid elongation_Homo sapiens_hsa00062	0.83728570
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82285306
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.81869851
56	Type II diabetes mellitus_Homo sapiens_hsa04930	0.77508948
57	Regulation of autophagy_Homo sapiens_hsa04140	0.76221321
58	Insulin secretion_Homo sapiens_hsa04911	0.74723261
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73641052
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72317874
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.69695056
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68308313
63	Alzheimers disease_Homo sapiens_hsa05010	0.66100114
64	Purine metabolism_Homo sapiens_hsa00230	0.64708144
65	Olfactory transduction_Homo sapiens_hsa04740	0.61901998
66	Peroxisome_Homo sapiens_hsa04146	0.61298458
67	TNF signaling pathway_Homo sapiens_hsa04668	0.59166850
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.58755941
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57283682
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56946758
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51281252
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49319443
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47685243
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.45980520
75	Serotonergic synapse_Homo sapiens_hsa04726	0.45228714
76	RNA transport_Homo sapiens_hsa03013	0.45097524
77	Huntingtons disease_Homo sapiens_hsa05016	0.44825757
78	Measles_Homo sapiens_hsa05162	0.43680688
79	Metabolic pathways_Homo sapiens_hsa01100	0.43161915
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42352227
81	Circadian rhythm_Homo sapiens_hsa04710	0.40256543
82	Nicotine addiction_Homo sapiens_hsa05033	0.38707631
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.38239136
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36754154
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35862781
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34477498
87	Taste transduction_Homo sapiens_hsa04742	0.34468104
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31523585
89	Retinol metabolism_Homo sapiens_hsa00830	0.30756302
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.30308019
91	Mineral absorption_Homo sapiens_hsa04978	0.29737756
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29254146
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27899552
94	One carbon pool by folate_Homo sapiens_hsa00670	0.26503353
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26140255
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25323389
97	Salivary secretion_Homo sapiens_hsa04970	0.24995835
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.23658704
99	Circadian entrainment_Homo sapiens_hsa04713	0.23622849
100	Herpes simplex infection_Homo sapiens_hsa05168	0.23293565

EIF4A2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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