ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	6.82120802
2	preassembly of GPI anchor in ER membrane (GO:0016254)	6.47978061
3	negative regulation of necroptotic process (GO:0060546)	5.65891865
4	mannosylation (GO:0097502)	5.34261423
5	retinal cone cell development (GO:0046549)	4.92326168
6	DNA deamination (GO:0045006)	4.88489294
7	righting reflex (GO:0060013)	4.73498862
8	GPI anchor biosynthetic process (GO:0006506)	4.58811192
9	negative regulation of necrotic cell death (GO:0060547)	4.54445568
10	C-terminal protein lipidation (GO:0006501)	4.51186347
11	C-terminal protein amino acid modification (GO:0018410)	4.45766483
12	serotonin receptor signaling pathway (GO:0007210)	4.35368647
13	N-acetylglucosamine metabolic process (GO:0006044)	4.28251394
14	GPI anchor metabolic process (GO:0006505)	4.28004070
15	behavioral response to ethanol (GO:0048149)	4.09640429
16	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.04569108
17	hepatocyte apoptotic process (GO:0097284)	4.03087712
18	heme transport (GO:0015886)	3.98465120
19	cellular ketone body metabolic process (GO:0046950)	3.96796311
20	adult feeding behavior (GO:0008343)	3.69078486
21	rRNA methylation (GO:0031167)	3.65178341
22	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.64326034
23	rRNA modification (GO:0000154)	3.60695318
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.56940657
25	detection of light stimulus involved in visual perception (GO:0050908)	3.56940657
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.53743846
27	embryonic epithelial tube formation (GO:0001838)	3.51548075
28	ketone body metabolic process (GO:1902224)	3.50735356
29	reflex (GO:0060004)	3.46738274
30	proteasome assembly (GO:0043248)	3.41413708
31	protein K6-linked ubiquitination (GO:0085020)	3.39288639
32	necroptotic process (GO:0070266)	3.37534837
33	iron-sulfur cluster assembly (GO:0016226)	3.37151978
34	metallo-sulfur cluster assembly (GO:0031163)	3.37151978
35	protein complex biogenesis (GO:0070271)	3.35105213
36	photoreceptor cell development (GO:0042461)	3.33693890
37	regulation of necroptotic process (GO:0060544)	3.29995086
38	cornea development in camera-type eye (GO:0061303)	3.29956054
39	regulation of protein polyubiquitination (GO:1902914)	3.29199207
40	epithelial tube formation (GO:0072175)	3.27651693
41	glycolipid biosynthetic process (GO:0009247)	3.24459153
42	regulation of RIG-I signaling pathway (GO:0039535)	3.20468107
43	somite development (GO:0061053)	3.18735901
44	lactate metabolic process (GO:0006089)	3.17548604
45	regulation of feeding behavior (GO:0060259)	3.13409985
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09550599
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09550599
48	NADH dehydrogenase complex assembly (GO:0010257)	3.09550599
49	fucose catabolic process (GO:0019317)	3.09429726
50	L-fucose metabolic process (GO:0042354)	3.09429726
51	L-fucose catabolic process (GO:0042355)	3.09429726
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.05495992
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03351442
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.02920051
55	estrogen biosynthetic process (GO:0006703)	2.99722219
56	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.98721215
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98337172
58	iron coordination entity transport (GO:1901678)	2.88274004
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.88208719
60	behavioral response to nicotine (GO:0035095)	2.87524700
61	positive regulation of mast cell degranulation (GO:0043306)	2.82751059
62	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.82751059
63	NIK/NF-kappaB signaling (GO:0038061)	2.82738490
64	ATP synthesis coupled proton transport (GO:0015986)	2.80979228
65	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.80979228
66	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.80870777
67	negative regulation of neurological system process (GO:0031645)	2.80577562
68	limb bud formation (GO:0060174)	2.79063518
69	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.78417010
70	meiotic chromosome segregation (GO:0045132)	2.76418375
71	xenobiotic catabolic process (GO:0042178)	2.76389280
72	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.76051752
73	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.75816849
74	isotype switching (GO:0045190)	2.75816849
75	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.75816849
76	glucosamine-containing compound metabolic process (GO:1901071)	2.75740274
77	glial cell proliferation (GO:0014009)	2.72840157
78	endocardial cushion morphogenesis (GO:0003203)	2.71606460
79	cellular response to leptin stimulus (GO:0044320)	2.71480313
80	positive regulation of guanylate cyclase activity (GO:0031284)	2.66447995
81	regulation of androgen receptor signaling pathway (GO:0060765)	2.65578636
82	negative regulation of receptor activity (GO:2000272)	2.64836781
83	positive regulation of glycolytic process (GO:0045821)	2.63661092
84	inositol phosphate catabolic process (GO:0071545)	2.60442437
85	regulation of cilium movement (GO:0003352)	2.59146048
86	spinal cord development (GO:0021510)	2.57331888
87	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.55402872
88	ATP hydrolysis coupled proton transport (GO:0015991)	2.55402872
89	eye photoreceptor cell development (GO:0042462)	2.55002581
90	pseudouridine synthesis (GO:0001522)	2.54524346
91	kynurenine metabolic process (GO:0070189)	2.53797322
92	potassium ion import (GO:0010107)	2.52458349
93	regulation of action potential (GO:0098900)	2.51443633
94	glomerulus development (GO:0032835)	2.51201047
95	cilium morphogenesis (GO:0060271)	2.47831443
96	piRNA metabolic process (GO:0034587)	2.44811584
97	dentate gyrus development (GO:0021542)	2.44568598
98	regulation of energy homeostasis (GO:2000505)	2.44308479
99	protein localization to cilium (GO:0061512)	2.44036736
100	positive regulation of cGMP biosynthetic process (GO:0030828)	2.42425578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.25615077
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.65958751
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.24254698
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84352463
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52601428
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.51561545
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46560873
8	EWS_26573619_Chip-Seq_HEK293_Human	2.43881901
9	VDR_22108803_ChIP-Seq_LS180_Human	2.42890686
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.38823804
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.34409015
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32988178
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17716398
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16409491
15	FUS_26573619_Chip-Seq_HEK293_Human	2.12879396
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98487966
17	P300_19829295_ChIP-Seq_ESCs_Human	1.84727685
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.84707088
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83066659
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.78471219
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.77951936
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75502924
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74264681
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.72997477
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.71464886
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64510856
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64376532
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60847626
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60332608
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58075553
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.57031349
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57031349
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.55073112
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.53259616
35	AR_25329375_ChIP-Seq_VCAP_Human	1.51255090
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.50620672
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49885820
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.46914617
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46579116
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44859992
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44859992
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43979421
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43770966
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42634572
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40160362
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39078907
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37922913
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.37147692
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36710453
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36638145
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.35692624
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34535947
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32707290
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31478949
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30124133
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28989721
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27247045
58	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26784665
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26664910
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25093113
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23456304
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17807071
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17143480
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.17093610
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17071375
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.15739420
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12928241
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12815680
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12348298
70	AR_20517297_ChIP-Seq_VCAP_Human	1.12096217
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11720760
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11720760
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11695983
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11302839
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10211241
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.08732478
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08464335
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07412848
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06034005
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06009223
81	TCF4_23295773_ChIP-Seq_U87_Human	1.05897113
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.05229492
83	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.03227455
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02685768
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01048342
86	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00236017
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00201521
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99635088
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99045973
90	NCOR_22424771_ChIP-Seq_293T_Human	0.98368121
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98164578
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97947239
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96811015
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96455043
95	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.96102280
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95589724
97	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.94275000
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94146224
99	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94128880
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93923842

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002009_preneoplasia	3.17072410
2	MP0002837_dystrophic_cardiac_calcinosis	2.80445645
3	MP0008877_abnormal_DNA_methylation	2.71046862
4	MP0002102_abnormal_ear_morphology	2.68604323
5	MP0002909_abnormal_adrenal_gland	2.65467027
6	MP0006072_abnormal_retinal_apoptosis	2.54438637
7	MP0002166_altered_tumor_susceptibility	2.41422896
8	MP0003787_abnormal_imprinting	2.41338658
9	MP0005645_abnormal_hypothalamus_physiol	2.24177597
10	MP0003718_maternal_effect	2.21561356
11	MP0002928_abnormal_bile_duct	2.21524578
12	MP0009046_muscle_twitch	2.18287745
13	MP0005551_abnormal_eye_electrophysiolog	2.17544918
14	MP0004142_abnormal_muscle_tone	2.10310393
15	MP0005253_abnormal_eye_physiology	2.04656813
16	MP0008995_early_reproductive_senescence	1.91461122
17	MP0005084_abnormal_gallbladder_morpholo	1.85894904
18	MP0001986_abnormal_taste_sensitivity	1.80442446
19	MP0005646_abnormal_pituitary_gland	1.78479237
20	MP0002735_abnormal_chemical_nociception	1.75576020
21	MP0000372_irregular_coat_pigmentation	1.75309052
22	MP0002006_tumorigenesis	1.74790805
23	MP0002822_catalepsy	1.74018634
24	MP0003191_abnormal_cellular_cholesterol	1.70599557
25	MP0003880_abnormal_central_pattern	1.69325744
26	MP0003011_delayed_dark_adaptation	1.69299875
27	MP0003195_calcinosis	1.68989358
28	MP0004885_abnormal_endolymph	1.67406975
29	MP0003221_abnormal_cardiomyocyte_apopto	1.61082586
30	MP0001968_abnormal_touch/_nociception	1.60229589
31	MP0003786_premature_aging	1.59167692
32	MP0002876_abnormal_thyroid_physiology	1.58214071
33	MP0002254_reproductive_system_inflammat	1.56062324
34	MP0000631_abnormal_neuroendocrine_gland	1.55799118
35	MP0000516_abnormal_urinary_system	1.53309047
36	MP0005367_renal/urinary_system_phenotyp	1.53309047
37	MP0002751_abnormal_autonomic_nervous	1.52601798
38	MP0002272_abnormal_nervous_system	1.49094191
39	MP0004215_abnormal_myocardial_fiber	1.47593879
40	MP0009745_abnormal_behavioral_response	1.47472836
41	MP0002572_abnormal_emotion/affect_behav	1.45058579
42	MP0006054_spinal_hemorrhage	1.43988990
43	MP0003252_abnormal_bile_duct	1.42148459
44	MP0003172_abnormal_lysosome_physiology	1.40329589
45	MP0001984_abnormal_olfaction	1.40268053
46	MP0002733_abnormal_thermal_nociception	1.37365492
47	MP0002736_abnormal_nociception_after	1.36148194
48	MP0006276_abnormal_autonomic_nervous	1.35744183
49	MP0000013_abnormal_adipose_tissue	1.34433464
50	MP0004270_analgesia	1.31074140
51	MP0009697_abnormal_copulation	1.30592538
52	MP0001970_abnormal_pain_threshold	1.30399447
53	MP0002396_abnormal_hematopoietic_system	1.29898762
54	MP0001529_abnormal_vocalization	1.29113384
55	MP0003638_abnormal_response/metabolism_	1.28581679
56	MP0001501_abnormal_sleep_pattern	1.27485423
57	MP0009764_decreased_sensitivity_to	1.25046383
58	MP0001905_abnormal_dopamine_level	1.25014105
59	MP0003119_abnormal_digestive_system	1.24753680
60	MP0001944_abnormal_pancreas_morphology	1.21440147
61	MP0006036_abnormal_mitochondrial_physio	1.20726568
62	MP0002160_abnormal_reproductive_system	1.19266701
63	MP0008872_abnormal_physiological_respon	1.15089392
64	MP0005410_abnormal_fertilization	1.13274263
65	MP0008775_abnormal_heart_ventricle	1.12715121
66	MP0006035_abnormal_mitochondrial_morpho	1.10728513
67	MP0004085_abnormal_heartbeat	1.07283484
68	MP0002064_seizures	1.07048110
69	MP0004019_abnormal_vitamin_homeostasis	1.05816056
70	MP0004782_abnormal_surfactant_physiolog	1.05635601
71	MP0008875_abnormal_xenobiotic_pharmacok	1.02533463
72	MP0004924_abnormal_behavior	1.01098208
73	MP0005386_behavior/neurological_phenoty	1.01098208
74	MP0005389_reproductive_system_phenotype	0.99767088
75	MP0000639_abnormal_adrenal_gland	0.97297506
76	MP0003137_abnormal_impulse_conducting	0.96441782
77	MP0005647_abnormal_sex_gland	0.95106199
78	MP0002229_neurodegeneration	0.91815440
79	MP0004145_abnormal_muscle_electrophysio	0.91791607
80	MP0005379_endocrine/exocrine_gland_phen	0.91600792
81	MP0002938_white_spotting	0.91056374
82	MP0000613_abnormal_salivary_gland	0.90989972
83	MP0001764_abnormal_homeostasis	0.88959848
84	MP0002557_abnormal_social/conspecific_i	0.88080653
85	MP0009780_abnormal_chondrocyte_physiolo	0.87331963
86	MP0005167_abnormal_blood-brain_barrier	0.86546488
87	MP0005448_abnormal_energy_balance	0.86221237
88	MP0004133_heterotaxia	0.85618499
89	MP0003635_abnormal_synaptic_transmissio	0.83011519
90	MP0002163_abnormal_gland_morphology	0.81642491
91	MP0005195_abnormal_posterior_eye	0.81564268
92	MP0006292_abnormal_olfactory_placode	0.80648335
93	MP0002063_abnormal_learning/memory/cond	0.80434292
94	MP0002184_abnormal_innervation	0.80141729
95	MP0003698_abnormal_male_reproductive	0.79877235
96	MP0002693_abnormal_pancreas_physiology	0.79521171
97	MP0001270_distended_abdomen	0.79147413
98	MP0000569_abnormal_digit_pigmentation	0.78592069
99	MP0002234_abnormal_pharynx_morphology	0.77837212
100	MP0000427_abnormal_hair_cycle	0.77057552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	4.86703052
2	Posterior subcapsular cataract (HP:0007787)	4.04154369
3	Hypoglycemic seizures (HP:0002173)	3.65028069
4	Ketoacidosis (HP:0001993)	3.29731403
5	Abnormality of the pancreatic islet cells (HP:0006476)	3.15434041
6	Abnormality of endocrine pancreas physiology (HP:0012093)	3.15434041
7	Hyperglycemia (HP:0003074)	3.12626640
8	Constricted visual fields (HP:0001133)	3.09509595
9	Increased CSF lactate (HP:0002490)	3.01617042
10	Medial flaring of the eyebrow (HP:0010747)	2.95826217
11	Acute necrotizing encephalopathy (HP:0006965)	2.92816720
12	Hypothermia (HP:0002045)	2.91977468
13	Large for gestational age (HP:0001520)	2.87952911
14	Hypoglycemic coma (HP:0001325)	2.87293272
15	Stomatitis (HP:0010280)	2.83635604
16	Hypochromic microcytic anemia (HP:0004840)	2.82097130
17	Hepatocellular necrosis (HP:0001404)	2.76081764
18	Pancreatic cysts (HP:0001737)	2.75675084
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.69219365
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.69219365
21	Progressive macrocephaly (HP:0004481)	2.66719367
22	Molar tooth sign on MRI (HP:0002419)	2.66247493
23	Abnormality of midbrain morphology (HP:0002418)	2.66247493
24	Methylmalonic acidemia (HP:0002912)	2.63696703
25	Nephronophthisis (HP:0000090)	2.62960976
26	Mitochondrial inheritance (HP:0001427)	2.61192184
27	Increased serum pyruvate (HP:0003542)	2.61088661
28	Limb dystonia (HP:0002451)	2.57746771
29	Increased hepatocellular lipid droplets (HP:0006565)	2.57669290
30	Hypoalbuminemia (HP:0003073)	2.56266649
31	Abnormal albumin level (HP:0012116)	2.56266649
32	Hepatic necrosis (HP:0002605)	2.51056681
33	Congenital stationary night blindness (HP:0007642)	2.49763100
34	Muscular hypotonia of the trunk (HP:0008936)	2.48404149
35	Acute encephalopathy (HP:0006846)	2.47930043
36	Lipid accumulation in hepatocytes (HP:0006561)	2.47029992
37	Ketosis (HP:0001946)	2.46381025
38	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45813936
39	Prominent metopic ridge (HP:0005487)	2.41987268
40	Neonatal respiratory distress (HP:0002643)	2.41656848
41	Delayed CNS myelination (HP:0002188)	2.39162617
42	Amniotic constriction ring (HP:0009775)	2.38753765
43	Abnormality of placental membranes (HP:0011409)	2.38753765
44	Type I diabetes mellitus (HP:0100651)	2.33269560
45	Type II lissencephaly (HP:0007260)	2.32261366
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.31855451
47	Tubular atrophy (HP:0000092)	2.31416910
48	Progressive inability to walk (HP:0002505)	2.29884554
49	3-Methylglutaconic aciduria (HP:0003535)	2.27701624
50	Pancreatic fibrosis (HP:0100732)	2.24139072
51	Inability to walk (HP:0002540)	2.23378581
52	Congenital, generalized hypertrichosis (HP:0004540)	2.22776922
53	Thyroid-stimulating hormone excess (HP:0002925)	2.22614576
54	Progressive microcephaly (HP:0000253)	2.21922571
55	Hypoplasia of the uterus (HP:0000013)	2.21414484
56	Hypoproteinemia (HP:0003075)	2.16583529
57	Adrenal hypoplasia (HP:0000835)	2.16178608
58	Abnormality of the metopic suture (HP:0005556)	2.16171611
59	Optic disc pallor (HP:0000543)	2.15550636
60	Congenital primary aphakia (HP:0007707)	2.15375643
61	Gait imbalance (HP:0002141)	2.15135005
62	Hypsarrhythmia (HP:0002521)	2.14024737
63	Abnormality of the renal cortex (HP:0011035)	2.13451113
64	Attenuation of retinal blood vessels (HP:0007843)	2.12789821
65	EEG with generalized epileptiform discharges (HP:0011198)	2.12496506
66	Type I transferrin isoform profile (HP:0003642)	2.12247724
67	Symptomatic seizures (HP:0011145)	2.12244449
68	True hermaphroditism (HP:0010459)	2.09183517
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08145371
70	Abnormality of the renal medulla (HP:0100957)	2.07906349
71	Subcapsular cataract (HP:0000523)	2.06540612
72	Chronic hepatic failure (HP:0100626)	2.05654554
73	Hypoplastic pelvis (HP:0008839)	2.04135012
74	Increased serum lactate (HP:0002151)	2.03408775
75	Abnormal rod and cone electroretinograms (HP:0008323)	2.03157001
76	Nephrogenic diabetes insipidus (HP:0009806)	2.03012781
77	Epileptiform EEG discharges (HP:0011182)	2.01703609
78	Polyuria (HP:0000103)	2.00488794
79	Abnormal drinking behavior (HP:0030082)	2.00484363
80	Polydipsia (HP:0001959)	2.00484363
81	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99587317
82	Lactic acidosis (HP:0003128)	1.98701960
83	Abnormality of glycolysis (HP:0004366)	1.98043471
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97699595
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.97699595
86	Abnormal protein glycosylation (HP:0012346)	1.97699595
87	Abnormal glycosylation (HP:0012345)	1.97699595
88	Abnormality of T cell physiology (HP:0011840)	1.96014167
89	Prominent supraorbital ridges (HP:0000336)	1.93395057
90	Abnormality of vitamin B metabolism (HP:0004340)	1.89774043
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.88337387
92	Cerebral hypomyelination (HP:0006808)	1.88331386
93	Hyperglycinemia (HP:0002154)	1.88293826
94	Leukodystrophy (HP:0002415)	1.88266627
95	Bile duct proliferation (HP:0001408)	1.86786164
96	Abnormal biliary tract physiology (HP:0012439)	1.86786164
97	Methylmalonic aciduria (HP:0012120)	1.84128088
98	Micronodular cirrhosis (HP:0001413)	1.83816325
99	Abolished electroretinogram (ERG) (HP:0000550)	1.83589514
100	Renal cortical cysts (HP:0000803)	1.83353499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.24566430
2	ADRBK2	2.96986144
3	CASK	2.85137980
4	ZAK	2.80859178
5	TIE1	2.78940750
6	MAP4K2	2.55302964
7	WNK3	2.49029907
8	MST4	2.46665152
9	TRIM28	2.40219300
10	ERBB3	2.34698880
11	MAP3K6	1.85774094
12	DAPK2	1.84164583
13	TSSK6	1.84026022
14	BCKDK	1.81692972
15	TLK1	1.79431493
16	BCR	1.77432983
17	EIF2AK3	1.75704198
18	KIT	1.75599195
19	NUAK1	1.74057547
20	GRK1	1.73376555
21	CSNK1G1	1.61907626
22	OXSR1	1.57725350
23	CSNK1G3	1.42657325
24	CSNK1G2	1.40636094
25	PINK1	1.39517311
26	TAOK3	1.38786925
27	PLK2	1.30324115
28	MAP3K4	1.26332930
29	VRK1	1.24732408
30	MAPK13	1.23469548
31	NLK	1.20542833
32	CSNK1A1L	1.17748576
33	MAP2K7	1.15819302
34	BMPR1B	1.13963652
35	MINK1	1.12342306
36	MARK1	1.08552035
37	PDK2	1.07191710
38	INSRR	1.06173281
39	PASK	1.02788739
40	AKT3	1.02734566
41	DYRK3	0.98681170
42	ADRBK1	0.95522812
43	PLK3	0.91631006
44	MKNK1	0.91604359
45	DYRK2	0.89803269
46	PNCK	0.87994541
47	FGFR2	0.84928967
48	MAP2K6	0.80543808
49	UHMK1	0.79695663
50	RPS6KA5	0.79152065
51	CDK3	0.77961077
52	TEC	0.77673857
53	NME1	0.77513945
54	SCYL2	0.76692462
55	MAPKAPK5	0.74462044
56	CAMK2D	0.74271560
57	MAP3K12	0.73910154
58	PRKCE	0.72025015
59	PKN1	0.68982790
60	NTRK3	0.68777170
61	CAMK2A	0.68572320
62	EIF2AK1	0.67748122
63	PRKCG	0.63105623
64	DYRK1B	0.57317300
65	LYN	0.56308461
66	SRPK1	0.55246773
67	YES1	0.55084224
68	IRAK4	0.53779043
69	MAPK15	0.52992864
70	STK39	0.52359022
71	PAK3	0.52185886
72	GRK7	0.51893965
73	CSNK1A1	0.51488324
74	FER	0.51162525
75	PRKACA	0.50965320
76	CDK6	0.48656743
77	CSNK1E	0.48065123
78	PHKG1	0.48000390
79	PHKG2	0.48000390
80	PTK2B	0.47463343
81	TNIK	0.46531330
82	FLT3	0.46319984
83	EPHA3	0.45674541
84	PRKACB	0.43942969
85	FES	0.43362836
86	TXK	0.42756721
87	ATM	0.42015945
88	CSNK2A1	0.41848530
89	PRKG1	0.40981349
90	PIK3CG	0.40759863
91	CAMK2G	0.40330287
92	DAPK1	0.38248117
93	PRKCA	0.38199244
94	OBSCN	0.34700761
95	TRPM7	0.34631561
96	EGFR	0.34190699
97	MYLK	0.34062783
98	CDK19	0.32859384
99	ILK	0.32131321
100	GRK5	0.31677458

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.31649907
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.68680109
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.64024016
4	Phototransduction_Homo sapiens_hsa04744	3.01369459
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.87859386
6	Butanoate metabolism_Homo sapiens_hsa00650	2.32919440
7	Protein export_Homo sapiens_hsa03060	2.28407308
8	Basal transcription factors_Homo sapiens_hsa03022	2.25823148
9	Asthma_Homo sapiens_hsa05310	2.14730137
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.12423307
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.99929753
12	Parkinsons disease_Homo sapiens_hsa05012	1.96855680
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.90323199
14	Proteasome_Homo sapiens_hsa03050	1.82609723
15	Propanoate metabolism_Homo sapiens_hsa00640	1.78663424
16	Steroid biosynthesis_Homo sapiens_hsa00100	1.71492172
17	RNA degradation_Homo sapiens_hsa03018	1.66800263
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63003740
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55569266
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54155696
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47985402
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.46365643
23	Alzheimers disease_Homo sapiens_hsa05010	1.44217542
24	Regulation of autophagy_Homo sapiens_hsa04140	1.42259201
25	Huntingtons disease_Homo sapiens_hsa05016	1.41277535
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.34560324
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29934958
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26710302
29	RNA polymerase_Homo sapiens_hsa03020	1.25731809
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25249230
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.22894672
32	Nicotine addiction_Homo sapiens_hsa05033	1.22292373
33	Insulin secretion_Homo sapiens_hsa04911	1.19062443
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18649826
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.18279610
36	Sulfur metabolism_Homo sapiens_hsa00920	1.18131509
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.13783301
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.06673620
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04374622
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04015431
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03970287
42	Allograft rejection_Homo sapiens_hsa05330	0.98144601
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.95935153
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95885298
45	Fatty acid elongation_Homo sapiens_hsa00062	0.95854836
46	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94851650
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93529727
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92673768
49	Taste transduction_Homo sapiens_hsa04742	0.88337627
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88182429
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84864070
52	Peroxisome_Homo sapiens_hsa04146	0.82960620
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80537835
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78925231
55	Folate biosynthesis_Homo sapiens_hsa00790	0.77647698
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76598846
57	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.74863292
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.73002653
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.72782447
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70710408
61	Serotonergic synapse_Homo sapiens_hsa04726	0.69372604
62	Circadian entrainment_Homo sapiens_hsa04713	0.67942742
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66307995
64	GABAergic synapse_Homo sapiens_hsa04727	0.65878013
65	Purine metabolism_Homo sapiens_hsa00230	0.65474806
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65300989
67	Metabolic pathways_Homo sapiens_hsa01100	0.63712819
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.59661997
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57357774
70	RNA transport_Homo sapiens_hsa03013	0.56447689
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55492342
72	Histidine metabolism_Homo sapiens_hsa00340	0.55067369
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54217362
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.53983404
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53918958
76	Morphine addiction_Homo sapiens_hsa05032	0.53642729
77	One carbon pool by folate_Homo sapiens_hsa00670	0.52207031
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.50896085
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50858298
80	Homologous recombination_Homo sapiens_hsa03440	0.49738502
81	Salivary secretion_Homo sapiens_hsa04970	0.48218553
82	Caffeine metabolism_Homo sapiens_hsa00232	0.47524408
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45931494
84	Olfactory transduction_Homo sapiens_hsa04740	0.45018259
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43773736
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43474239
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43274897
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.42992599
89	Legionellosis_Homo sapiens_hsa05134	0.41857877
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40367764
91	Renin secretion_Homo sapiens_hsa04924	0.38865180
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.38485302
93	ABC transporters_Homo sapiens_hsa02010	0.38418489
94	Fanconi anemia pathway_Homo sapiens_hsa03460	0.36702380
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.36427783
96	Viral myocarditis_Homo sapiens_hsa05416	0.36278145
97	Primary immunodeficiency_Homo sapiens_hsa05340	0.35271516
98	Fatty acid degradation_Homo sapiens_hsa00071	0.34088682
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.33582002
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32959427

EIF4A2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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