EIF4A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.05393294
2DNA strand elongation (GO:0022616)4.81686183
3telomere maintenance via semi-conservative replication (GO:0032201)4.70909174
4establishment of integrated proviral latency (GO:0075713)4.70363028
5DNA replication initiation (GO:0006270)4.69514676
6DNA replication checkpoint (GO:0000076)4.53200055
7formation of translation preinitiation complex (GO:0001731)4.46002345
8nucleobase biosynthetic process (GO:0046112)4.45213423
9DNA unwinding involved in DNA replication (GO:0006268)4.39457313
10maturation of SSU-rRNA (GO:0030490)4.31701767
11telomere maintenance via recombination (GO:0000722)4.26117754
12purine nucleobase biosynthetic process (GO:0009113)4.25686277
13ribosomal small subunit assembly (GO:0000028)4.21394787
14protein localization to kinetochore (GO:0034501)4.12385917
15DNA deamination (GO:0045006)4.09435524
16establishment of viral latency (GO:0019043)4.07792642
17regulation of mitochondrial translation (GO:0070129)4.07409558
18mitotic metaphase plate congression (GO:0007080)4.04708932
19mitotic recombination (GO:0006312)4.03411666
20DNA replication-dependent nucleosome organization (GO:0034723)3.80015427
21DNA replication-dependent nucleosome assembly (GO:0006335)3.80015427
22ribosome biogenesis (GO:0042254)3.79631817
23CENP-A containing nucleosome assembly (GO:0034080)3.79348922
24telomere maintenance via telomere lengthening (GO:0010833)3.78627163
25ribosome assembly (GO:0042255)3.77207444
26chromatin remodeling at centromere (GO:0031055)3.71832751
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.69878855
28mitotic nuclear envelope disassembly (GO:0007077)3.66576125
29regulation of cellular amino acid metabolic process (GO:0006521)3.66524188
30IMP biosynthetic process (GO:0006188)3.66409678
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.66025225
32ribonucleoprotein complex biogenesis (GO:0022613)3.63939066
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59970548
34ribosomal large subunit biogenesis (GO:0042273)3.58693200
35nuclear pore complex assembly (GO:0051292)3.58658891
36viral transcription (GO:0019083)3.56720359
37translational termination (GO:0006415)3.54886617
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54176372
39DNA replication-independent nucleosome organization (GO:0034724)3.53001835
40DNA replication-independent nucleosome assembly (GO:0006336)3.53001835
41proteasome assembly (GO:0043248)3.52652686
42spliceosomal snRNP assembly (GO:0000387)3.51935993
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50363548
44nucleobase-containing small molecule interconversion (GO:0015949)3.50335714
45metaphase plate congression (GO:0051310)3.48092230
46ribosomal small subunit biogenesis (GO:0042274)3.47668618
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46909050
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45407398
49protein localization to chromosome, centromeric region (GO:0071459)3.44091822
50translational initiation (GO:0006413)3.39604434
51attachment of spindle microtubules to kinetochore (GO:0008608)3.39215680
52positive regulation of ligase activity (GO:0051351)3.39019240
53peptidyl-arginine omega-N-methylation (GO:0035247)3.38264557
54* rRNA processing (GO:0006364)3.38261828
55regulation of ubiquitin-protein transferase activity (GO:0051438)3.36550170
56sister chromatid segregation (GO:0000819)3.36221616
57nuclear envelope disassembly (GO:0051081)3.36200214
58membrane disassembly (GO:0030397)3.36200214
59translational elongation (GO:0006414)3.31419206
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.30350872
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29727032
62negative regulation of ligase activity (GO:0051352)3.29727032
63transcription-coupled nucleotide-excision repair (GO:0006283)3.29288477
64kinetochore organization (GO:0051383)3.28340010
65folic acid-containing compound biosynthetic process (GO:0009396)3.27700439
66* rRNA metabolic process (GO:0016072)3.26482815
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26302398
68regulation of translational termination (GO:0006449)3.23156259
69regulation of ligase activity (GO:0051340)3.23092692
70negative regulation of mRNA processing (GO:0050686)3.22589764
71cell cycle G1/S phase transition (GO:0044843)3.22481796
72G1/S transition of mitotic cell cycle (GO:0000082)3.22481796
73protein complex localization (GO:0031503)3.20435020
74IMP metabolic process (GO:0046040)3.18660398
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17884294
76nuclear pore organization (GO:0006999)3.17783732
77rRNA modification (GO:0000154)3.15605893
78histone exchange (GO:0043486)3.12942518
79spliceosomal complex assembly (GO:0000245)3.12428533
80histone arginine methylation (GO:0034969)3.11525468
81establishment of chromosome localization (GO:0051303)3.11146392
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.10971793
83de novo protein folding (GO:0006458)3.10593982
84protein maturation by protein folding (GO:0022417)3.10574073
85cotranslational protein targeting to membrane (GO:0006613)3.10021757
86regulation of spindle organization (GO:0090224)3.09428848
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08119918
88pseudouridine synthesis (GO:0001522)3.07875930
89viral mRNA export from host cell nucleus (GO:0046784)3.07756626
90protein targeting to ER (GO:0045047)3.07735655
91kinetochore assembly (GO:0051382)3.07224333
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05495165
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04965736
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04965736
95DNA ligation (GO:0006266)3.04813501
96mitotic chromosome condensation (GO:0007076)3.04687305
97termination of RNA polymerase III transcription (GO:0006386)3.04422055
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.04422055
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03923583
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03923583
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03923583
102cullin deneddylation (GO:0010388)3.03734170
103* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02593122
104de novo posttranslational protein folding (GO:0051084)3.01161075
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.01102427
106signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01102427
107somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00879600
108somatic hypermutation of immunoglobulin genes (GO:0016446)3.00879600
109negative regulation of chromosome segregation (GO:0051985)3.00583931
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.99572905
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99572905
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99572905
113negative regulation of sister chromatid segregation (GO:0033046)2.99572905
114regulation of translational fidelity (GO:0006450)2.99066741
115mitotic sister chromatid segregation (GO:0000070)2.98929442
116protein deneddylation (GO:0000338)2.97955379
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.97772259
118spindle checkpoint (GO:0031577)2.97539274
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97469777
120termination of RNA polymerase II transcription (GO:0006369)2.96265817
1217-methylguanosine mRNA capping (GO:0006370)2.96154302
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95932431
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95658678
124telomere organization (GO:0032200)2.94777614
125maturation of 5.8S rRNA (GO:0000460)2.93995393
126translation (GO:0006412)2.93362471
127deoxyribonucleotide biosynthetic process (GO:0009263)2.92814456
128protein targeting to mitochondrion (GO:0006626)2.92118958
129pore complex assembly (GO:0046931)2.91947861
130tRNA aminoacylation for protein translation (GO:0006418)2.91892190
131base-excision repair (GO:0006284)2.90835858
132nuclear envelope reassembly (GO:0031468)2.86377956
133mitotic nuclear envelope reassembly (GO:0007084)2.86377956
134negative regulation of protein ubiquitination (GO:0031397)2.86346179
135negative regulation of RNA splicing (GO:0033119)2.84910041
136mitochondrial RNA metabolic process (GO:0000959)2.84791106
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84372787
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.84253705
139tRNA aminoacylation (GO:0043039)2.83166775
140amino acid activation (GO:0043038)2.83166775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20250518
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.29727888
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75829844
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53129626
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.50320042
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47190195
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17293464
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.14730028
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12600386
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01061911
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.98205174
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97433718
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91876078
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87439330
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85389359
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61226505
17* XRN2_22483619_ChIP-Seq_HELA_Human2.43447230
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42636824
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40230143
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34913721
21VDR_23849224_ChIP-Seq_CD4+_Human2.33295998
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16864852
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16687662
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14749441
25DCP1A_22483619_ChIP-Seq_HELA_Human2.12497151
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10473845
27FOXP3_21729870_ChIP-Seq_TREG_Human2.06105910
28AR_21909140_ChIP-Seq_LNCAP_Human2.00551650
29GABP_19822575_ChIP-Seq_HepG2_Human2.00546098
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94569592
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93378227
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92336150
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91593829
34TTF2_22483619_ChIP-Seq_HELA_Human1.88912890
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.88172137
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86313856
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80634373
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78732315
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75959306
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.72226101
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70928007
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69085893
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66384059
44ELK1_19687146_ChIP-ChIP_HELA_Human1.65952006
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63888618
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62495166
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60048380
48ZNF263_19887448_ChIP-Seq_K562_Human1.57436351
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56784543
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.55711264
51* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52383250
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51761990
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51523057
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.50240391
55MYC_22102868_ChIP-Seq_BL_Human1.43567848
56KDM5A_27292631_Chip-Seq_BREAST_Human1.42892506
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42805882
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36067247
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34362528
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31669861
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31145841
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24555526
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21025768
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19935745
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19901289
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17856305
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16845846
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16799932
69TFEB_21752829_ChIP-Seq_HELA_Human1.15855814
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15598717
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14762798
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13866111
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13418555
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.11449968
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10596978
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.10342582
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08097465
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07802079
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07510454
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06067871
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05165788
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03187503
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02750315
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01249169
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00946947
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00815755
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00216678
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.97985572
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94950397
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94613554
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93449109
92MYC_18940864_ChIP-ChIP_HL60_Human0.93231962
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92612513
94* SPI1_23547873_ChIP-Seq_NB4_Human0.92150434
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92138915
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92005986
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89706113
98VDR_21846776_ChIP-Seq_THP-1_Human0.89656660
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88776936
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87670107
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87132677
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87037446
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86013610
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.85982563
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85797067
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84785911
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84637775
108CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84509616
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84414199
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.78558722
111* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76716323
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76272155
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75092069
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72737003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59220621
2MP0010094_abnormal_chromosome_stability4.74793343
3MP0004957_abnormal_blastocyst_morpholog4.54246765
4MP0003111_abnormal_nucleus_morphology4.40734724
5MP0003077_abnormal_cell_cycle4.08761790
6MP0008057_abnormal_DNA_replication3.96115525
7MP0008058_abnormal_DNA_repair3.64397003
8MP0008007_abnormal_cellular_replicative3.03807789
9MP0008932_abnormal_embryonic_tissue2.83447200
10MP0002877_abnormal_melanocyte_morpholog2.72438290
11MP0003123_paternal_imprinting2.43452690
12MP0001730_embryonic_growth_arrest2.41187271
13MP0002396_abnormal_hematopoietic_system2.36657178
14MP0003786_premature_aging2.24728997
15MP0008877_abnormal_DNA_methylation2.23354791
16MP0000350_abnormal_cell_proliferation2.20295943
17MP0004233_abnormal_muscle_weight2.01468200
18MP0010234_abnormal_vibrissa_follicle2.00156131
19MP0000372_irregular_coat_pigmentation1.99671838
20MP0001697_abnormal_embryo_size1.72221055
21MP0000490_abnormal_crypts_of1.68010282
22MP0001672_abnormal_embryogenesis/_devel1.67245233
23MP0005380_embryogenesis_phenotype1.67245233
24MP0003718_maternal_effect1.67035897
25MP0005501_abnormal_skin_physiology1.66994102
26MP0009697_abnormal_copulation1.64158509
27MP0010352_gastrointestinal_tract_polyps1.63882792
28MP0010307_abnormal_tumor_latency1.62874059
29MP0009333_abnormal_splenocyte_physiolog1.60930235
30MP0002080_prenatal_lethality1.58664471
31MP0002796_impaired_skin_barrier1.56696258
32MP0010030_abnormal_orbit_morphology1.55164898
33MP0003984_embryonic_growth_retardation1.52229963
34MP0000313_abnormal_cell_death1.50643321
35MP0002088_abnormal_embryonic_growth/wei1.47554453
36MP0004808_abnormal_hematopoietic_stem1.47476464
37MP0002085_abnormal_embryonic_tissue1.47240965
38MP0002019_abnormal_tumor_incidence1.44728456
39MP0003763_abnormal_thymus_physiology1.33142503
40MP0003806_abnormal_nucleotide_metabolis1.31535184
41MP0005408_hypopigmentation1.30613597
42MP0002084_abnormal_developmental_patter1.28940985
43MP0002210_abnormal_sex_determination1.28366971
44MP0001293_anophthalmia1.28249848
45MP0002086_abnormal_extraembryonic_tissu1.24702347
46MP0005451_abnormal_body_composition1.23412411
47MP0003567_abnormal_fetal_cardiomyocyte1.23228876
48MP0003121_genomic_imprinting1.22349422
49MP0002102_abnormal_ear_morphology1.21301899
50MP0004197_abnormal_fetal_growth/weight/1.18307389
51MP0000703_abnormal_thymus_morphology1.17178783
52MP0003315_abnormal_perineum_morphology1.16450632
53MP0002398_abnormal_bone_marrow1.12249066
54MP0001145_abnormal_male_reproductive1.11809415
55MP0006292_abnormal_olfactory_placode1.08992605
56MP0003890_abnormal_embryonic-extraembry1.06985081
57MP0002722_abnormal_immune_system1.06808942
58MP0005397_hematopoietic_system_phenotyp1.06619600
59MP0001545_abnormal_hematopoietic_system1.06619600
60MP0002653_abnormal_ependyma_morphology1.04671217
61MP0002697_abnormal_eye_size1.01856033
62MP0000689_abnormal_spleen_morphology1.01258173
63MP0006054_spinal_hemorrhage0.99412033
64MP0001881_abnormal_mammary_gland0.99272216
65MP0000358_abnormal_cell_content/0.98184035
66MP0003186_abnormal_redox_activity0.97905781
67MP0001929_abnormal_gametogenesis0.97104845
68MP0005171_absent_coat_pigmentation0.96610468
69MP0000537_abnormal_urethra_morphology0.96262298
70MP0001346_abnormal_lacrimal_gland0.96166834
71MP0001529_abnormal_vocalization0.95398105
72MP0002098_abnormal_vibrissa_morphology0.94608083
73MP0002160_abnormal_reproductive_system0.94364288
74MP0000653_abnormal_sex_gland0.93029256
75MP0005058_abnormal_lysosome_morphology0.92154413
76MP0002429_abnormal_blood_cell0.91853830
77MP0003136_yellow_coat_color0.91453820
78MP0002132_abnormal_respiratory_system0.89869983
79MP0003119_abnormal_digestive_system0.85211799
80MP0003221_abnormal_cardiomyocyte_apopto0.83394412
81MP0002938_white_spotting0.82094142
82MP0005384_cellular_phenotype0.81700695
83MP0001216_abnormal_epidermal_layer0.81220256
84MP0005075_abnormal_melanosome_morpholog0.79999608
85MP0001119_abnormal_female_reproductive0.79711344
86MP0000858_altered_metastatic_potential0.79258991
87MP0005257_abnormal_intraocular_pressure0.78898685
88MP0000716_abnormal_immune_system0.77919077
89MP0001853_heart_inflammation0.77078963
90MP0002111_abnormal_tail_morphology0.75675080
91MP0000627_abnormal_mammary_gland0.75218211
92MP0005671_abnormal_response_to0.75027946
93MP0005621_abnormal_cell_physiology0.74094934
94MP0000647_abnormal_sebaceous_gland0.73748275
95MP0005389_reproductive_system_phenotype0.72784845
96MP0004133_heterotaxia0.71482138
97MP0009672_abnormal_birth_weight0.71451426
98MP0009053_abnormal_anal_canal0.70090388
99MP0001186_pigmentation_phenotype0.69980240
100MP0005076_abnormal_cell_differentiation0.69626188
101MP0008260_abnormal_autophagy0.66727038
102MP0001915_intracranial_hemorrhage0.66703683
103MP0001243_abnormal_dermal_layer0.66385130
104MP0006036_abnormal_mitochondrial_physio0.65449282
105MP0005023_abnormal_wound_healing0.64309987
106MP0005197_abnormal_uvea_morphology0.64113910
107MP0002075_abnormal_coat/hair_pigmentati0.63824896
108MP0003937_abnormal_limbs/digits/tail_de0.63226388
109MP0002060_abnormal_skin_morphology0.62666859
110MP0003941_abnormal_skin_development0.62456923
111MP0002092_abnormal_eye_morphology0.62057123
112MP0001661_extended_life_span0.61398124
113MP0002420_abnormal_adaptive_immunity0.60776601
114MP0002177_abnormal_outer_ear0.60706173
115MP0000477_abnormal_intestine_morphology0.60042019
116MP0000762_abnormal_tongue_morphology0.59850691
117MP0001819_abnormal_immune_cell0.59686243
118MP0002095_abnormal_skin_pigmentation0.59565293
119MP0000015_abnormal_ear_pigmentation0.59329971
120MP0004264_abnormal_extraembryonic_tissu0.59020484
121MP0000465_gastrointestinal_hemorrhage0.58344755
122MP0001286_abnormal_eye_development0.57817347
123MP0010771_integument_phenotype0.57155669
124MP0000049_abnormal_middle_ear0.56041574
125MP0003699_abnormal_female_reproductive0.55715488
126MP0000467_abnormal_esophagus_morphology0.55625161
127MP0008789_abnormal_olfactory_epithelium0.55613047
128MP0002163_abnormal_gland_morphology0.55360498
129MP0001835_abnormal_antigen_presentation0.55265918
130MP0001800_abnormal_humoral_immune0.54356938
131MP0003943_abnormal_hepatobiliary_system0.54241103
132MP0000428_abnormal_craniofacial_morphol0.53840265
133MP0001727_abnormal_embryo_implantation0.53180732
134MP0000685_abnormal_immune_system0.51942043
135MP0006035_abnormal_mitochondrial_morpho0.51826318
136MP0000750_abnormal_muscle_regeneration0.51615094

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.60333542
2Microvesicular hepatic steatosis (HP:0001414)4.41992800
3Breast hypoplasia (HP:0003187)4.19359174
4Reticulocytopenia (HP:0001896)4.14588794
5Abnormality of cells of the erythroid lineage (HP:0012130)4.02281133
6Abnormal number of erythroid precursors (HP:0012131)3.82919888
7Abnormality of the anterior horn cell (HP:0006802)3.79225474
8Degeneration of anterior horn cells (HP:0002398)3.79225474
9Cerebral hypomyelination (HP:0006808)3.69230686
10Oral leukoplakia (HP:0002745)3.64288117
11Patellar aplasia (HP:0006443)3.61503302
12Chromsome breakage (HP:0040012)3.60317565
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51826208
14Carpal bone hypoplasia (HP:0001498)3.40555342
15Aplasia/Hypoplasia of the patella (HP:0006498)3.40475418
16Rough bone trabeculation (HP:0100670)3.34865402
17Colon cancer (HP:0003003)3.27376370
18Aplastic anemia (HP:0001915)3.26603345
19Abnormal mitochondria in muscle tissue (HP:0008316)3.25148966
20Meckel diverticulum (HP:0002245)3.20470706
21Abnormality of the preputium (HP:0100587)3.12410271
22Abnormality of the ileum (HP:0001549)3.11428725
23Ragged-red muscle fibers (HP:0003200)3.10057193
24Abnormality of chromosome stability (HP:0003220)2.99031031
25Acute necrotizing encephalopathy (HP:0006965)2.97260403
26Increased CSF lactate (HP:0002490)2.94041439
27Abnormal protein glycosylation (HP:0012346)2.93164803
28Abnormal glycosylation (HP:0012345)2.93164803
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.93164803
30Abnormal protein N-linked glycosylation (HP:0012347)2.93164803
31Hepatocellular necrosis (HP:0001404)2.88578869
32Increased hepatocellular lipid droplets (HP:0006565)2.88511866
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.84292073
34Medulloblastoma (HP:0002885)2.81867930
35Ependymoma (HP:0002888)2.79231596
36Macrocytic anemia (HP:0001972)2.77037081
37Trismus (HP:0000211)2.74704420
38Absent thumb (HP:0009777)2.74215278
39Reduced antithrombin III activity (HP:0001976)2.73899953
40Mitochondrial inheritance (HP:0001427)2.69988912
41Premature graying of hair (HP:0002216)2.67841215
42Acute encephalopathy (HP:0006846)2.67135140
43Lipid accumulation in hepatocytes (HP:0006561)2.64975096
44Bone marrow hypocellularity (HP:0005528)2.62329078
45Absent radius (HP:0003974)2.62040683
46Small intestinal stenosis (HP:0012848)2.61681559
47Duodenal stenosis (HP:0100867)2.61681559
48Spastic diplegia (HP:0001264)2.61360513
4911 pairs of ribs (HP:0000878)2.60607025
50Agnosia (HP:0010524)2.58516445
51Pallor (HP:0000980)2.55379543
52Myelodysplasia (HP:0002863)2.54553902
53Impulsivity (HP:0100710)2.52847692
54Neoplasm of the pancreas (HP:0002894)2.52277221
55Hepatic necrosis (HP:0002605)2.50980076
56Increased intramyocellular lipid droplets (HP:0012240)2.49394490
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.48699184
58Lactic acidosis (HP:0003128)2.47109070
59Shoulder girdle muscle weakness (HP:0003547)2.45579296
60Abnormal lung lobation (HP:0002101)2.44108777
61Abnormal trabecular bone morphology (HP:0100671)2.43345785
62Aplasia involving forearm bones (HP:0009822)2.42023811
63Absent forearm bone (HP:0003953)2.42023811
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39314912
65Cerebral edema (HP:0002181)2.36041178
66Testicular atrophy (HP:0000029)2.35371343
67Multiple enchondromatosis (HP:0005701)2.33975748
68Cellular immunodeficiency (HP:0005374)2.30037867
69Progressive external ophthalmoplegia (HP:0000590)2.29135418
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28220671
71Exercise intolerance (HP:0003546)2.26459111
72Atresia of the external auditory canal (HP:0000413)2.26283736
73Secondary amenorrhea (HP:0000869)2.25487018
74Thrombocytosis (HP:0001894)2.21831966
75Horseshoe kidney (HP:0000085)2.21769906
76Tracheoesophageal fistula (HP:0002575)2.20912293
77Sloping forehead (HP:0000340)2.20655263
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19569753
79Premature ovarian failure (HP:0008209)2.19251607
80Triphalangeal thumb (HP:0001199)2.17875654
81Type I transferrin isoform profile (HP:0003642)2.17485421
82Cleft eyelid (HP:0000625)2.15711915
83Abnormality of the duodenum (HP:0002246)2.14404030
84Abnormality of the labia minora (HP:0012880)2.11939838
85Upper limb muscle weakness (HP:0003484)2.11717490
86Atrophy/Degeneration involving motor neurons (HP:0007373)2.11022074
87Slender long bone (HP:0003100)2.10954695
88Hypokinesia (HP:0002375)2.10772869
89Rhabdomyosarcoma (HP:0002859)2.10056892
90Increased muscle lipid content (HP:0009058)2.08606533
91CNS hypomyelination (HP:0003429)2.07686510
92Cortical dysplasia (HP:0002539)2.07679837
93Lymphoma (HP:0002665)2.06794390
94Ectopic kidney (HP:0000086)2.06761196
95* Facial cleft (HP:0002006)2.05679296
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05036858
97Abnormality of alanine metabolism (HP:0010916)2.05036858
98Hyperalaninemia (HP:0003348)2.05036858
99IgM deficiency (HP:0002850)2.04601522
100Abnormal gallbladder physiology (HP:0012438)2.03300369
101Cholecystitis (HP:0001082)2.03300369
102Supernumerary spleens (HP:0009799)2.03063191
103Abnormality of the umbilical cord (HP:0010881)2.02769661
104Progressive macrocephaly (HP:0004481)2.00499010
105Pancytopenia (HP:0001876)1.99605877
106Duplicated collecting system (HP:0000081)1.99522576
107Fasciculations (HP:0002380)1.97902322
108Irregular epiphyses (HP:0010582)1.97505467
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96990280
110Absent epiphyses (HP:0010577)1.96990280
111Death in infancy (HP:0001522)1.96693309
112Abnormality of glycolysis (HP:0004366)1.96295541
113Increased serum pyruvate (HP:0003542)1.96295541
114* Proximal placement of thumb (HP:0009623)1.93523945
115Muscle fiber atrophy (HP:0100295)1.93129380
116Basal cell carcinoma (HP:0002671)1.92103156
117* Selective tooth agenesis (HP:0001592)1.91524748
118Increased serum lactate (HP:0002151)1.89609992
119Increased nuchal translucency (HP:0010880)1.87849744
120Pelvic girdle muscle weakness (HP:0003749)1.87644618
121Abnormality of the renal collecting system (HP:0004742)1.87148720
122Type 2 muscle fiber atrophy (HP:0003554)1.87010946
123* Deviation of the thumb (HP:0009603)1.86748701
124Amaurosis fugax (HP:0100576)1.83487982
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82340475
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82340475
127Abnormal spermatogenesis (HP:0008669)1.82312158
128Postnatal microcephaly (HP:0005484)1.81073159
129Squamous cell carcinoma (HP:0002860)1.80877474
130Abnormality of the carotid arteries (HP:0005344)1.79847523
131Spinal muscular atrophy (HP:0007269)1.79827216
132Hypergonadotropic hypogonadism (HP:0000815)1.79821644
133Ureteral duplication (HP:0000073)1.78035041
134Respiratory failure (HP:0002878)1.77769713
135Optic nerve coloboma (HP:0000588)1.77621968
136Poor head control (HP:0002421)1.77414069
137Gout (HP:0001997)1.77351593
138Abnormal umbilical cord blood vessels (HP:0011403)1.77178612
139Single umbilical artery (HP:0001195)1.77178612
140Abnormality of the fetal cardiovascular system (HP:0010948)1.77178612
141Megaloblastic anemia (HP:0001889)1.75943944
142Renal Fanconi syndrome (HP:0001994)1.75293129
143Stenosis of the external auditory canal (HP:0000402)1.74422348
144Respiratory difficulties (HP:0002880)1.72885493
145Progressive muscle weakness (HP:0003323)1.70705334
146Sparse eyelashes (HP:0000653)1.70516381
147Neoplasm of the colon (HP:0100273)1.69543422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.22900415
2WEE14.31750392
3CDC73.60611430
4EIF2AK13.39612648
5VRK23.22750966
6TSSK62.68065563
7ACVR1B2.58090836
8STK162.56721662
9SRPK12.46473788
10NEK22.45118219
11PASK2.38861915
12BRSK22.37122496
13EIF2AK32.36513818
14NME22.27657588
15PLK42.25490209
16VRK12.05560875
17NEK12.03680901
18PLK11.93780134
19TESK21.92566903
20TTK1.89161164
21PDK21.78969188
22SMG11.78377651
23MKNK11.67371209
24DYRK31.66377130
25CDK71.64433231
26CCNB11.61237209
27RPS6KA41.58644966
28AURKB1.57121543
29ATR1.56429328
30BRSK11.53487098
31PLK31.51503079
32TLK11.50903271
33RPS6KB21.41420781
34TGFBR11.37905228
35CHEK21.25785265
36AURKA1.24772654
37IRAK31.19803995
38ZAK1.18562456
39CSNK1G31.17353177
40MST1R1.16697696
41MAP3K81.16435310
42PIM21.15789968
43TRIM281.13682934
44CDK41.12544684
45PAK41.10739526
46EPHA21.09913189
47MKNK21.08890701
48CHEK11.08300207
49STK101.07137831
50SCYL21.05900552
51CSNK1A1L1.02325665
52KDR0.98207928
53STK40.93036293
54CDK80.90628634
55TESK10.85718280
56DAPK10.84943618
57ARAF0.84786237
58CSNK1G10.82641672
59MAP4K10.81408909
60PIM10.80338546
61PBK0.78877097
62BRAF0.78720099
63CDK120.77878288
64MAP2K70.75793397
65PAK10.75477161
66FLT30.74229850
67CLK10.72152243
68EEF2K0.71182118
69EIF2AK20.70960234
70TAF10.70829537
71* CDK20.69236756
72CSNK2A10.69039552
73MST40.67482639
74CSNK2A20.67416844
75ATM0.66914344
76CSNK1G20.65915795
77ABL20.63650650
78ICK0.62398504
79MAP3K100.61213898
80CDK190.60248330
81RPS6KA50.58666129
82BCKDK0.58225355
83LIMK10.58049994
84PRKCI0.57479911
85DYRK20.57347988
86ERBB40.56855958
87NME10.56742960
88LRRK20.56386235
89MAP3K110.55872686
90CDK10.52253053
91TAOK20.51128012
92MAP3K120.50057826
93LATS20.48661799
94CDK140.47874228
95ZAP700.47744262
96MELK0.46915142
97MAP2K30.45098776
98CDK11A0.44775150
99CDK180.42267492
100BTK0.41679687
101CDK150.40387756
102ILK0.39900697
103CDK90.37434300
104RAF10.36542442
105BRD40.36243813
106MAPKAPK30.35541934
107STK38L0.34509680
108MAP3K140.34067830
109NUAK10.31821626
110ALK0.31415915
111CDK60.30886469
112ERBB30.29205741
113MAP3K30.28901755
114IRAK40.28345652
115TYK20.28195319
116MAPKAPK20.27036091
117PDK30.25176054
118PDK40.25176054
119TEC0.24694328
120STK30.22942044
121BCR0.22910596
122JAK30.22694030
123YES10.21658341
124BLK0.19953912
125AKT20.19630553
126SIK30.18770878
127CSNK1E0.18601155
128PRKDC0.18113242
129MARK30.17856088
130CHUK0.16777004

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99634652
2Mismatch repair_Homo sapiens_hsa034304.21479444
3Proteasome_Homo sapiens_hsa030503.89858367
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66582429
5Ribosome_Homo sapiens_hsa030103.50561943
6RNA polymerase_Homo sapiens_hsa030203.45969464
7* Spliceosome_Homo sapiens_hsa030403.29742934
8Base excision repair_Homo sapiens_hsa034103.10204042
9* RNA transport_Homo sapiens_hsa030132.99530133
10Homologous recombination_Homo sapiens_hsa034402.89681675
11Nucleotide excision repair_Homo sapiens_hsa034202.84931177
12Cell cycle_Homo sapiens_hsa041102.65032980
13Pyrimidine metabolism_Homo sapiens_hsa002402.60416292
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36005364
15One carbon pool by folate_Homo sapiens_hsa006702.36004905
16Fanconi anemia pathway_Homo sapiens_hsa034602.10496442
17Basal transcription factors_Homo sapiens_hsa030222.00632776
18Non-homologous end-joining_Homo sapiens_hsa034501.86270184
19RNA degradation_Homo sapiens_hsa030181.83971893
20p53 signaling pathway_Homo sapiens_hsa041151.51854522
21* mRNA surveillance pathway_Homo sapiens_hsa030151.45707535
22Purine metabolism_Homo sapiens_hsa002301.43328231
23Protein export_Homo sapiens_hsa030601.33961350
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29870488
25Epstein-Barr virus infection_Homo sapiens_hsa051691.29466507
26Fatty acid elongation_Homo sapiens_hsa000621.28759643
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13497537
28Pyruvate metabolism_Homo sapiens_hsa006201.00773866
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99659715
30Folate biosynthesis_Homo sapiens_hsa007900.99340955
31Systemic lupus erythematosus_Homo sapiens_hsa053220.96779282
32Antigen processing and presentation_Homo sapiens_hsa046120.96485315
33Herpes simplex infection_Homo sapiens_hsa051680.93497066
34Alzheimers disease_Homo sapiens_hsa050100.91625588
35Vitamin B6 metabolism_Homo sapiens_hsa007500.89219264
36Viral carcinogenesis_Homo sapiens_hsa052030.87063376
37Steroid biosynthesis_Homo sapiens_hsa001000.85324145
38Pentose phosphate pathway_Homo sapiens_hsa000300.85272237
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85040237
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83200673
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.80414353
42Oocyte meiosis_Homo sapiens_hsa041140.78831789
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77439608
44Biosynthesis of amino acids_Homo sapiens_hsa012300.77050526
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.70877233
46HTLV-I infection_Homo sapiens_hsa051660.69500881
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69001515
48Sulfur metabolism_Homo sapiens_hsa009200.68632293
49Huntingtons disease_Homo sapiens_hsa050160.66391817
50Legionellosis_Homo sapiens_hsa051340.65487604
51Primary immunodeficiency_Homo sapiens_hsa053400.65420677
52Selenocompound metabolism_Homo sapiens_hsa004500.64220384
53Sulfur relay system_Homo sapiens_hsa041220.63971535
54Parkinsons disease_Homo sapiens_hsa050120.60083445
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.57286668
56Vibrio cholerae infection_Homo sapiens_hsa051100.55876308
57N-Glycan biosynthesis_Homo sapiens_hsa005100.54267746
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54029585
59Thyroid cancer_Homo sapiens_hsa052160.53473533
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51628985
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51151084
62Glutathione metabolism_Homo sapiens_hsa004800.50961799
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48446890
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.45761803
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45080079
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43863042
67Measles_Homo sapiens_hsa051620.43855521
68Small cell lung cancer_Homo sapiens_hsa052220.43616159
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42906047
70Apoptosis_Homo sapiens_hsa042100.42879299
71Shigellosis_Homo sapiens_hsa051310.40350160
72Carbon metabolism_Homo sapiens_hsa012000.40172123
73Arginine and proline metabolism_Homo sapiens_hsa003300.38972644
74MicroRNAs in cancer_Homo sapiens_hsa052060.37911599
75Oxidative phosphorylation_Homo sapiens_hsa001900.37852197
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36119916
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33688892
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33652124
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31885373
80Phenylalanine metabolism_Homo sapiens_hsa003600.31445575
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.31317644
82Hippo signaling pathway_Homo sapiens_hsa043900.30200475
83Hepatitis B_Homo sapiens_hsa051610.29565982
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28062969
85Alcoholism_Homo sapiens_hsa050340.27906469
86TGF-beta signaling pathway_Homo sapiens_hsa043500.27752303
87Colorectal cancer_Homo sapiens_hsa052100.26916813
88Notch signaling pathway_Homo sapiens_hsa043300.26798548
89Regulation of autophagy_Homo sapiens_hsa041400.26795258
90Asthma_Homo sapiens_hsa053100.26703729
91Fructose and mannose metabolism_Homo sapiens_hsa000510.26701999
92Fatty acid metabolism_Homo sapiens_hsa012120.26560572
93Basal cell carcinoma_Homo sapiens_hsa052170.25383204
94Metabolic pathways_Homo sapiens_hsa011000.25356607
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.24939234
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24227012
97Influenza A_Homo sapiens_hsa051640.23867707
98Galactose metabolism_Homo sapiens_hsa000520.22242424
99Hematopoietic cell lineage_Homo sapiens_hsa046400.21134448
100Allograft rejection_Homo sapiens_hsa053300.20753442
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20574159
102Viral myocarditis_Homo sapiens_hsa054160.20265460
103Tyrosine metabolism_Homo sapiens_hsa003500.20044212
104HIF-1 signaling pathway_Homo sapiens_hsa040660.19029528
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18721856
106Salmonella infection_Homo sapiens_hsa051320.17306662
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16976381
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16813066
109Propanoate metabolism_Homo sapiens_hsa006400.16503470
110Pathways in cancer_Homo sapiens_hsa052000.16024813
111Renin-angiotensin system_Homo sapiens_hsa046140.15532281
112Arachidonic acid metabolism_Homo sapiens_hsa005900.14221163
113Arginine biosynthesis_Homo sapiens_hsa002200.14178646
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13904685
115Bladder cancer_Homo sapiens_hsa052190.13177284
116Graft-versus-host disease_Homo sapiens_hsa053320.12753595
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12189149
118Hedgehog signaling pathway_Homo sapiens_hsa043400.11094806
119Acute myeloid leukemia_Homo sapiens_hsa052210.10333292
120Cardiac muscle contraction_Homo sapiens_hsa042600.10266235
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05723520
122Peroxisome_Homo sapiens_hsa041460.04880532

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »