EIF4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.17755100
2pore complex assembly (GO:0046931)6.07676735
3embryonic process involved in female pregnancy (GO:0060136)5.63743694
4regulation of translational fidelity (GO:0006450)5.29301584
5establishment of apical/basal cell polarity (GO:0035089)4.97384164
6mitotic sister chromatid cohesion (GO:0007064)4.70271528
7transcription from mitochondrial promoter (GO:0006390)4.44806354
8mitotic G1 DNA damage checkpoint (GO:0031571)4.43380311
9replication fork processing (GO:0031297)4.39108202
10formation of translation preinitiation complex (GO:0001731)4.34695824
11proline metabolic process (GO:0006560)4.32774604
12negative regulation of DNA repair (GO:0045738)4.31870084
13mitotic chromosome condensation (GO:0007076)4.27043291
14regulation of integrin activation (GO:0033623)4.24016556
15dosage compensation (GO:0007549)4.18604832
16regulation of RNA export from nucleus (GO:0046831)4.15171501
17establishment of monopolar cell polarity (GO:0061162)4.12963049
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.12963049
19spliceosomal tri-snRNP complex assembly (GO:0000244)4.09700739
20negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06955490
21regulation of sister chromatid cohesion (GO:0007063)4.04071431
22somatic hypermutation of immunoglobulin genes (GO:0016446)4.03531560
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.03531560
24pre-miRNA processing (GO:0031054)3.99351074
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.89432334
26G1 DNA damage checkpoint (GO:0044783)3.87398652
27mitotic G1/S transition checkpoint (GO:0044819)3.84271255
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.84182829
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.84182829
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.84182829
31ribosome assembly (GO:0042255)3.79582820
32regulation of posttranscriptional gene silencing (GO:0060147)3.79185732
33regulation of gene silencing by miRNA (GO:0060964)3.79185732
34regulation of gene silencing by RNA (GO:0060966)3.79185732
35mRNA cleavage (GO:0006379)3.76129262
36mitochondrial DNA metabolic process (GO:0032042)3.75739307
37DNA unwinding involved in DNA replication (GO:0006268)3.71495324
38nuclear pore organization (GO:0006999)3.63155665
39regulation of histone H3-K27 methylation (GO:0061085)3.59959498
40mRNA stabilization (GO:0048255)3.57170243
41RNA stabilization (GO:0043489)3.57170243
42embryonic placenta development (GO:0001892)3.56606579
43heterochromatin organization (GO:0070828)3.56502638
44positive regulation of protein homooligomerization (GO:0032464)3.56189597
45negative regulation of mRNA processing (GO:0050686)3.56133041
46mitotic nuclear envelope disassembly (GO:0007077)3.55208382
47folic acid-containing compound biosynthetic process (GO:0009396)3.53759923
48trophectodermal cell differentiation (GO:0001829)3.53055797
49Golgi transport vesicle coating (GO:0048200)3.51217956
50COPI coating of Golgi vesicle (GO:0048205)3.51217956
51negative regulation of RNA splicing (GO:0033119)3.50997392
52positive regulation of chromosome segregation (GO:0051984)3.48576151
53nuclear pore complex assembly (GO:0051292)3.48267487
54regulation of centriole replication (GO:0046599)3.46641646
55protein complex localization (GO:0031503)3.45732948
56protein export from nucleus (GO:0006611)3.41398471
57DNA topological change (GO:0006265)3.34512609
58membrane disassembly (GO:0030397)3.33589771
59nuclear envelope disassembly (GO:0051081)3.33589771
60cellular protein complex localization (GO:0034629)3.32949043
61mitotic sister chromatid segregation (GO:0000070)3.30335324
62sister chromatid segregation (GO:0000819)3.28621581
63DNA strand renaturation (GO:0000733)3.27507968
64protein localization to kinetochore (GO:0034501)3.26943771
65base-excision repair (GO:0006284)3.26022955
66apoptotic process involved in morphogenesis (GO:0060561)3.25839092
67oxidative demethylation (GO:0070989)3.24895141
68telomere maintenance via semi-conservative replication (GO:0032201)3.24710874
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24474447
70DNA strand elongation involved in DNA replication (GO:0006271)3.23664922
71DNA duplex unwinding (GO:0032508)3.23609872
72negative regulation of mRNA metabolic process (GO:1903312)3.23379813
73DNA geometric change (GO:0032392)3.21228799
74regulation of nucleobase-containing compound transport (GO:0032239)3.21030108
75regulation of hippo signaling (GO:0035330)3.20524489
76peptidyl-lysine dimethylation (GO:0018027)3.19291780
77regulation of protein homooligomerization (GO:0032462)3.18465032
78DNA conformation change (GO:0071103)3.16857247
79regulation of DNA damage checkpoint (GO:2000001)3.09711753
80protein localization to chromosome, centromeric region (GO:0071459)3.07636664
81DNA replication initiation (GO:0006270)3.03164060
82DNA strand elongation (GO:0022616)3.02371069
83nodal signaling pathway (GO:0038092)3.01568493
84negative regulation of fatty acid biosynthetic process (GO:0045717)3.01338193
85nucleotide-excision repair, DNA gap filling (GO:0006297)2.97115971
86histone H4-K12 acetylation (GO:0043983)2.95798863
87nuclear envelope organization (GO:0006998)2.95478286
88cytoplasmic mRNA processing body assembly (GO:0033962)2.94840640
89negative regulation of cell cycle arrest (GO:0071157)2.94482874
90termination of RNA polymerase II transcription (GO:0006369)2.93187661
91establishment of integrated proviral latency (GO:0075713)2.92860946
92viral mRNA export from host cell nucleus (GO:0046784)2.91749924
93determination of adult lifespan (GO:0008340)2.91242295
94DNA deamination (GO:0045006)2.90492875
95nucleosome disassembly (GO:0006337)2.89536320
96protein-DNA complex disassembly (GO:0032986)2.89536320
97histone H3-K36 demethylation (GO:0070544)2.88277451
98regulation of mitotic spindle organization (GO:0060236)2.86239462
99positive regulation by host of viral transcription (GO:0043923)2.82706554
100negative regulation of histone methylation (GO:0031061)2.82478374
101mRNA transport (GO:0051028)2.81110630
102IMP biosynthetic process (GO:0006188)2.80233372
103anatomical structure regression (GO:0060033)2.78739708
104chromatin assembly (GO:0031497)2.78049030
105regulation of mRNA stability (GO:0043488)2.77510139
106definitive hemopoiesis (GO:0060216)2.77210121
107meiotic chromosome segregation (GO:0045132)2.76899802
108regulation of histone H3-K9 methylation (GO:0051570)2.76826851
109embryonic camera-type eye development (GO:0031076)2.75930054
110cellular response to epidermal growth factor stimulus (GO:0071364)2.75194967
111paraxial mesoderm development (GO:0048339)2.74716460
112NLS-bearing protein import into nucleus (GO:0006607)2.74517230
113response to epidermal growth factor (GO:0070849)2.73758279
114telomere maintenance via recombination (GO:0000722)2.73296429
115positive regulation of SMAD protein import into nucleus (GO:0060391)2.72525899
116positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.71548757
117chromosome condensation (GO:0030261)2.70974653
118polarized epithelial cell differentiation (GO:0030859)2.70296060
119regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.70217338
120regulation of centrosome duplication (GO:0010824)2.70118112
121double-strand break repair via nonhomologous end joining (GO:0006303)2.70105037
122non-recombinational repair (GO:0000726)2.70105037
123cellular hyperosmotic response (GO:0071474)2.69280394
124regulation of centrosome cycle (GO:0046605)2.67810931
125nucleus organization (GO:0006997)2.67758496
126regulation of translational elongation (GO:0006448)2.67364273
127maternal placenta development (GO:0001893)2.67274006
128positive regulation of protein oligomerization (GO:0032461)2.66469219
129embryonic camera-type eye morphogenesis (GO:0048596)2.66368986
130poly(A)+ mRNA export from nucleus (GO:0016973)2.63365215
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63122768
132intracellular estrogen receptor signaling pathway (GO:0030520)2.62233870
133regulation of double-strand break repair (GO:2000779)2.61702401
134mRNA export from nucleus (GO:0006406)2.61583801
135positive regulation of cell cycle checkpoint (GO:1901978)2.59806714
136mitotic recombination (GO:0006312)2.59682351
137convergent extension (GO:0060026)2.59104272
138negative regulation of JAK-STAT cascade (GO:0046426)2.59005477
139glutamine metabolic process (GO:0006541)2.56423268
140IMP metabolic process (GO:0046040)2.56403240
141regulation of histone methylation (GO:0031060)2.56371523
142COPII vesicle coating (GO:0048208)2.54497670
143V(D)J recombination (GO:0033151)2.53865109
144* nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53711944
145regulation of chromosome segregation (GO:0051983)2.52681487
146regulation of RNA stability (GO:0043487)2.52133468
147regulation of spindle organization (GO:0090224)2.51990652
148DNA synthesis involved in DNA repair (GO:0000731)2.50988274
149embryonic eye morphogenesis (GO:0048048)2.50568280
150positive regulation of protein import into nucleus, translocation (GO:0033160)2.48546677
151regulation of histone H3-K4 methylation (GO:0051569)2.44594341
152nucleic acid transport (GO:0050657)2.41564460
153RNA transport (GO:0050658)2.41564460
154establishment of RNA localization (GO:0051236)2.41564460
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.40585260
156histone H3-K9 demethylation (GO:0033169)2.39943533
157histone lysine demethylation (GO:0070076)2.39202825
158negative regulation of fibroblast apoptotic process (GO:2000270)2.37435526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07813192
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.81766935
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.20400340
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.06069371
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77797681
6MYC_22102868_ChIP-Seq_BL_Human2.74656169
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65682588
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53954540
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.49796834
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40873465
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36571946
12VDR_21846776_ChIP-Seq_THP-1_Human2.23982824
13* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22521277
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16339287
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15193443
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05465349
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05465349
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05465349
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98595627
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95303022
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94634027
22* CLOCK_20551151_ChIP-Seq_293T_Human1.90868491
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86585927
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86245058
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.80823601
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80763922
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76893400
28ZNF263_19887448_ChIP-Seq_K562_Human1.74459216
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73875407
30* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73101285
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72604477
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72344871
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70290248
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68118857
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63852147
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61599636
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.61052135
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60710891
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60641341
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60101441
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59900384
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58720688
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56227189
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.54492412
45GATA1_22025678_ChIP-Seq_K562_Human1.51144538
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50760442
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50597984
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49355701
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48214656
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47102448
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45593433
52AR_21909140_ChIP-Seq_LNCAP_Human1.45339398
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45265551
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44741763
55* XRN2_22483619_ChIP-Seq_HELA_Human1.44640056
56* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44158615
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43811476
58KDM2B_26808549_Chip-Seq_DND41_Human1.41866758
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41672763
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.39504758
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39081542
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38939807
63TCF7_22412390_ChIP-Seq_EML_Mouse1.38183287
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.37089578
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.35543982
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34436083
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34371705
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33960594
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32860106
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31045086
71* KDM5A_27292631_Chip-Seq_BREAST_Human1.30118050
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.28697318
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28417010
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26903772
75LXR_22292898_ChIP-Seq_THP-1_Human1.26758425
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26384796
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25990220
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24004341
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.23045110
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22056134
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20338245
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19669563
83ATF3_27146783_Chip-Seq_COLON_Human1.17200200
84* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16859167
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16685738
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14463110
87PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12726259
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12265832
89* CHD1_26751641_Chip-Seq_LNCaP_Human1.11879911
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11607083
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11086566
92* TFEB_21752829_ChIP-Seq_HELA_Human1.10639899
93TTF2_22483619_ChIP-Seq_HELA_Human1.10104614
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09585612
95* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09086808
96MAF_26560356_Chip-Seq_TH1_Human1.08580587
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07915986
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07821884
99CIITA_25753668_ChIP-Seq_RAJI_Human1.07508149
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07409829
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.06428157
102UTX_26944678_Chip-Seq_JUKART_Human1.05846075
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05586749
104* GABP_19822575_ChIP-Seq_HepG2_Human1.04978480
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.04927503
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04544435
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02701072
108DCP1A_22483619_ChIP-Seq_HELA_Human1.02654641
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02247980
110SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02166663
111OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01882952
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01415045
113NCOR1_26117541_ChIP-Seq_K562_Human1.01313489
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01034801
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00772967
116* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00283760
117* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99985902
118ELK1_19687146_ChIP-ChIP_HELA_Human0.99840876
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99541109
120* SOX17_20123909_ChIP-Seq_XEN_Mouse0.99511448
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99332907
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99191557
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99154385
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98631372
125GATA6_25053715_ChIP-Seq_YYC3_Human0.97232952
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96399952
127POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96262829
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95534931
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94369958
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92376243
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92259259
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92031325
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91866760
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91769206
135* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90821891
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89716155
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88796135
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87486644
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86934540
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85582601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.07992589
2MP0010352_gastrointestinal_tract_polyps3.23241460
3MP0009278_abnormal_bone_marrow3.09784423
4MP0003705_abnormal_hypodermis_morpholog2.96982379
5MP0010030_abnormal_orbit_morphology2.78871446
6MP0005076_abnormal_cell_differentiation2.77563107
7MP0010094_abnormal_chromosome_stability2.73003862
8MP0004957_abnormal_blastocyst_morpholog2.66141101
9MP0003111_abnormal_nucleus_morphology2.45077143
10MP0004233_abnormal_muscle_weight2.36739937
11MP0003077_abnormal_cell_cycle2.14001446
12MP0003693_abnormal_embryo_hatching2.13276354
13MP0004197_abnormal_fetal_growth/weight/1.98873911
14MP0010307_abnormal_tumor_latency1.97212117
15MP0002084_abnormal_developmental_patter1.95725601
16MP0001730_embryonic_growth_arrest1.93554068
17MP0002086_abnormal_extraembryonic_tissu1.93250052
18MP0003890_abnormal_embryonic-extraembry1.87546573
19MP0001697_abnormal_embryo_size1.82342022
20MP0009672_abnormal_birth_weight1.82223062
21MP0002009_preneoplasia1.80295586
22MP0000350_abnormal_cell_proliferation1.78588862
23MP0001672_abnormal_embryogenesis/_devel1.73742284
24MP0005380_embryogenesis_phenotype1.73742284
25MP0005397_hematopoietic_system_phenotyp1.71381188
26MP0001545_abnormal_hematopoietic_system1.71381188
27MP0002085_abnormal_embryonic_tissue1.71234844
28MP0003567_abnormal_fetal_cardiomyocyte1.69035537
29MP0003566_abnormal_cell_adhesion1.66917735
30MP0003283_abnormal_digestive_organ1.64850332
31MP0003119_abnormal_digestive_system1.62470590
32MP0001661_extended_life_span1.61281816
33MP0003984_embryonic_growth_retardation1.56611341
34MP0002088_abnormal_embryonic_growth/wei1.54596811
35MP0005451_abnormal_body_composition1.51557125
36MP0010234_abnormal_vibrissa_follicle1.50589636
37MP0009053_abnormal_anal_canal1.50501336
38MP0001293_anophthalmia1.49256639
39MP0003453_abnormal_keratinocyte_physiol1.48427400
40MP0000490_abnormal_crypts_of1.45799947
41MP0002006_tumorigenesis1.44768375
42MP0008932_abnormal_embryonic_tissue1.44203584
43MP0002080_prenatal_lethality1.43956254
44MP0010678_abnormal_skin_adnexa1.38849761
45MP0003221_abnormal_cardiomyocyte_apopto1.35747313
46MP0002877_abnormal_melanocyte_morpholog1.32369466
47MP0002396_abnormal_hematopoietic_system1.31696346
48MP0005171_absent_coat_pigmentation1.31152967
49MP0005023_abnormal_wound_healing1.30797308
50MP0008058_abnormal_DNA_repair1.29788759
51MP0003763_abnormal_thymus_physiology1.25047699
52MP0002653_abnormal_ependyma_morphology1.24929482
53MP0004264_abnormal_extraembryonic_tissu1.23398634
54MP0003786_premature_aging1.23351843
55MP0002282_abnormal_trachea_morphology1.23326427
56MP0000537_abnormal_urethra_morphology1.22616805
57MP0005409_darkened_coat_color1.19533249
58MP0001849_ear_inflammation1.19088743
59MP0002111_abnormal_tail_morphology1.16317199
60MP0000371_diluted_coat_color1.13533140
61MP0008007_abnormal_cellular_replicative1.13213641
62MP0004185_abnormal_adipocyte_glucose1.13173934
63MP0000733_abnormal_muscle_development1.12968280
64MP0002019_abnormal_tumor_incidence1.12948266
65MP0004133_heterotaxia1.10970529
66MP0009697_abnormal_copulation1.10072865
67MP0000377_abnormal_hair_follicle1.07333052
68MP0005621_abnormal_cell_physiology1.07030316
69MP0002249_abnormal_larynx_morphology1.05854097
70MP0001915_intracranial_hemorrhage1.03079714
71MP0002060_abnormal_skin_morphology1.00411698
72MP0002269_muscular_atrophy1.00013934
73MP0003935_abnormal_craniofacial_develop0.98276289
74MP0002796_impaired_skin_barrier0.97800528
75MP0005623_abnormal_meninges_morphology0.97684116
76MP0004808_abnormal_hematopoietic_stem0.97284236
77MP0002166_altered_tumor_susceptibility0.97135347
78MP0003091_abnormal_cell_migration0.97040433
79MP0008438_abnormal_cutaneous_collagen0.92936746
80MP0002697_abnormal_eye_size0.92597987
81MP0005501_abnormal_skin_physiology0.92559104
82MP0000313_abnormal_cell_death0.91422588
83MP0005666_abnormal_adipose_tissue0.91408532
84MP0002092_abnormal_eye_morphology0.91395502
85MP0008995_early_reproductive_senescence0.91346458
86MP0005408_hypopigmentation0.91131940
87MP0003123_paternal_imprinting0.90746837
88MP0010630_abnormal_cardiac_muscle0.90348008
89MP0002932_abnormal_joint_morphology0.89265459
90MP0008877_abnormal_DNA_methylation0.89218081
91MP0003943_abnormal_hepatobiliary_system0.88833240
92MP0000627_abnormal_mammary_gland0.88806199
93MP0003937_abnormal_limbs/digits/tail_de0.88538343
94MP0005174_abnormal_tail_pigmentation0.88193742
95MP0002925_abnormal_cardiovascular_devel0.88042892
96MP0005384_cellular_phenotype0.87467906
97MP0004087_abnormal_muscle_fiber0.87438406
98MP0004272_abnormal_basement_membrane0.87014878
99MP0000432_abnormal_head_morphology0.86854656
100MP0009703_decreased_birth_body0.84663654
101MP0003656_abnormal_erythrocyte_physiolo0.83455762
102MP0000477_abnormal_intestine_morphology0.83367658
103MP0000383_abnormal_hair_follicle0.82885839
104MP0000428_abnormal_craniofacial_morphol0.80727585
105MP0005248_abnormal_Harderian_gland0.78822118
106MP0003300_gastrointestinal_ulcer0.77881457
107MP0004381_abnormal_hair_follicle0.77077352
108MP0003115_abnormal_respiratory_system0.75664911
109MP0003755_abnormal_palate_morphology0.73148586
110MP0003385_abnormal_body_wall0.72837887
111MP0008770_decreased_survivor_rate0.72616720
112MP0003045_fibrosis0.71131272
113MP0005220_abnormal_exocrine_pancreas0.70817296
114MP0003941_abnormal_skin_development0.70462347
115MP0002075_abnormal_coat/hair_pigmentati0.69844750
116MP0000703_abnormal_thymus_morphology0.69677087
117MP0005367_renal/urinary_system_phenotyp0.69491795
118MP0000516_abnormal_urinary_system0.69491795
119MP0001784_abnormal_fluid_regulation0.69443152
120MP0006054_spinal_hemorrhage0.69216021
121MP0001286_abnormal_eye_development0.68840186
122MP0004782_abnormal_surfactant_physiolog0.68735393
123MP0000467_abnormal_esophagus_morphology0.68595829
124MP0000266_abnormal_heart_morphology0.68485980
125MP0002114_abnormal_axial_skeleton0.68388990
126MP0001216_abnormal_epidermal_layer0.68276235
127MP0006072_abnormal_retinal_apoptosis0.68165248
128MP0000470_abnormal_stomach_morphology0.67860790
129MP0001340_abnormal_eyelid_morphology0.65773154
130MP0000747_muscle_weakness0.65675502
131MP0000462_abnormal_digestive_system0.64744979
132MP0002098_abnormal_vibrissa_morphology0.62258751

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)4.13941267
2Ulnar bowing (HP:0003031)3.92440721
3Facial hemangioma (HP:0000329)3.74801713
4Rib fusion (HP:0000902)3.68330906
5Cerebral aneurysm (HP:0004944)3.42253604
6Selective tooth agenesis (HP:0001592)3.39796195
7Annular pancreas (HP:0001734)3.23302281
8Short humerus (HP:0005792)3.18853580
9Poikiloderma (HP:0001029)3.16773193
10Chromsome breakage (HP:0040012)3.13669574
11Turricephaly (HP:0000262)3.13353076
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12418043
13Volvulus (HP:0002580)3.10519660
14Ankyloglossia (HP:0010296)3.08835872
15Astrocytoma (HP:0009592)3.08804593
16Abnormality of the astrocytes (HP:0100707)3.08804593
17Ependymoma (HP:0002888)3.08465685
18Pustule (HP:0200039)3.00745560
19Papillary thyroid carcinoma (HP:0002895)3.00106778
20Aplasia/hypoplasia of the humerus (HP:0006507)2.99672213
21Basal cell carcinoma (HP:0002671)2.98890647
22Alopecia of scalp (HP:0002293)2.97166958
23Dysmetric saccades (HP:0000641)2.87258698
24Nephroblastoma (Wilms tumor) (HP:0002667)2.82736850
25Vertebral hypoplasia (HP:0008417)2.82174833
26Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.82174833
27Deep philtrum (HP:0002002)2.79475778
28Spinal cord lesions (HP:0100561)2.76803574
29Syringomyelia (HP:0003396)2.76803574
30Squamous cell carcinoma (HP:0002860)2.68303288
31Embryonal renal neoplasm (HP:0011794)2.62099392
32Coronal craniosynostosis (HP:0004440)2.58813058
33Rectovaginal fistula (HP:0000143)2.58660677
34Rectal fistula (HP:0100590)2.58660677
35Hypochromic microcytic anemia (HP:0004840)2.57168117
36Acute myeloid leukemia (HP:0004808)2.56924926
37Abnormality of oral frenula (HP:0000190)2.54061844
38Subacute progressive viral hepatitis (HP:0006572)2.51786675
39Intestinal fistula (HP:0100819)2.50566017
40Abnormal hemoglobin (HP:0011902)2.49880117
41Termporal pattern (HP:0011008)2.49146955
42Insidious onset (HP:0003587)2.49146955
43Bowed forearm bones (HP:0003956)2.46108836
44Bowing of the arm (HP:0006488)2.46108836
45Orthostatic hypotension (HP:0001278)2.44853605
46Progressive external ophthalmoplegia (HP:0000590)2.43336880
47Congenital hip dislocation (HP:0001374)2.42912623
48Neoplasm of the oral cavity (HP:0100649)2.40908415
49Vaginal fistula (HP:0004320)2.35863680
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29573794
51Absent radius (HP:0003974)2.28839529
52Concave nail (HP:0001598)2.27087458
53Glioma (HP:0009733)2.26828181
54Protrusio acetabuli (HP:0003179)2.24687606
55Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.23834124
56Leiomyosarcoma (HP:0100243)2.21744280
57Uterine leiomyosarcoma (HP:0002891)2.21744280
58Germ cell neoplasia (HP:0100728)2.20736950
59Flat acetabular roof (HP:0003180)2.20131181
60Abnormality of the fingertips (HP:0001211)2.19768475
61Absent thumb (HP:0009777)2.19004457
62Abnormality of the labia minora (HP:0012880)2.18975737
63Tongue fasciculations (HP:0001308)2.17523295
64Sandal gap (HP:0001852)2.17311034
65Thyroid carcinoma (HP:0002890)2.16949402
66Male infertility (HP:0003251)2.15657459
67Subaortic stenosis (HP:0001682)2.15430702
68Abnormality of the left ventricular outflow tract (HP:0011103)2.15430702
69Curly hair (HP:0002212)2.13738497
70Muscle fibrillation (HP:0010546)2.11989342
71Absent forearm bone (HP:0003953)2.10867254
72Aplasia involving forearm bones (HP:0009822)2.10867254
73Short chin (HP:0000331)2.10153014
74Vertebral fusion (HP:0002948)2.09699761
75Relative macrocephaly (HP:0004482)2.09643672
76Deviation of the thumb (HP:0009603)2.09615644
77Heterotopia (HP:0002282)2.09432040
78Transitional cell carcinoma of the bladder (HP:0006740)2.09243413
79Abnormal number of incisors (HP:0011064)2.08376240
80Patellar aplasia (HP:0006443)2.06968572
81Cafe-au-lait spot (HP:0000957)2.06732989
82Proximal placement of thumb (HP:0009623)2.05421261
83Missing ribs (HP:0000921)2.04426730
84Osteolytic defects of the hand bones (HP:0009699)2.03336396
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.03336396
86Broad alveolar ridges (HP:0000187)2.02808207
87Spastic diplegia (HP:0001264)2.02471880
88Sparse lateral eyebrow (HP:0005338)2.01222336
89Right ventricular cardiomyopathy (HP:0011663)2.01108380
90Skull defect (HP:0001362)2.00910279
91Broad thumb (HP:0011304)2.00817166
92Ankle contracture (HP:0006466)2.00685092
93Vertebral arch anomaly (HP:0008438)1.97991465
94Abnormality of the calcaneus (HP:0008364)1.97681755
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97162232
96Short 4th metacarpal (HP:0010044)1.97162232
97Colon cancer (HP:0003003)1.95690185
98Increased mean platelet volume (HP:0011877)1.95334493
99Advanced eruption of teeth (HP:0006288)1.94483107
100Bladder neoplasm (HP:0009725)1.92173945
101Bladder carcinoma (HP:0002862)1.92173945
102Microglossia (HP:0000171)1.91781915
103Multiple enchondromatosis (HP:0005701)1.91638759
104Aplasia/Hypoplasia of the patella (HP:0006498)1.91304864
105Rhabdomyosarcoma (HP:0002859)1.89894323
106Shallow orbits (HP:0000586)1.88237477
107Short 5th finger (HP:0009237)1.88042378
108Progressive muscle weakness (HP:0003323)1.87688754
109Hypotelorism (HP:0000601)1.86282262
110High anterior hairline (HP:0009890)1.86154609
111Pseudobulbar signs (HP:0002200)1.85643197
112Micronodular cirrhosis (HP:0001413)1.85399536
113Metaphyseal cupping (HP:0003021)1.84478626
114Overlapping toe (HP:0001845)1.83647653
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.83421499
116Hamartoma (HP:0010566)1.82878257
117IgA deficiency (HP:0002720)1.82265695
118Abnormal foot bone ossification (HP:0010675)1.81502795
119Pancreatic islet-cell hyperplasia (HP:0004510)1.80834300
120Viral hepatitis (HP:0006562)1.80810302
121Colitis (HP:0002583)1.80795231
122Genu recurvatum (HP:0002816)1.80764687
123Anal stenosis (HP:0002025)1.80656839
124Abnormal platelet volume (HP:0011876)1.80182824
125Hyperacusis (HP:0010780)1.79639121
126Cortical dysplasia (HP:0002539)1.79235041
127Abnormality of chromosome stability (HP:0003220)1.78801571
128Medulloblastoma (HP:0002885)1.77544263
129Intestinal atresia (HP:0011100)1.77511119
130Embryonal neoplasm (HP:0002898)1.76751946
131Hypochromic anemia (HP:0001931)1.76178250
132Premature skin wrinkling (HP:0100678)1.76143979
133Cystic hygroma (HP:0000476)1.75767100
134Insomnia (HP:0100785)1.75742104
135Split hand (HP:0001171)1.75646621
136Anteriorly placed anus (HP:0001545)1.75120453
137Vertebral clefting (HP:0008428)1.74979618
138Neoplasm of striated muscle (HP:0009728)1.73927922
139Cubitus valgus (HP:0002967)1.73595351
140Neoplasm of the adrenal cortex (HP:0100641)1.71645076
141Gastrointestinal carcinoma (HP:0002672)1.70761055
142Malignant gastrointestinal tract tumors (HP:0006749)1.70761055
143Breech presentation (HP:0001623)1.70466383
144Polycythemia (HP:0001901)1.70012608
145Biliary tract neoplasm (HP:0100574)1.69595458
146Breast carcinoma (HP:0003002)1.69324705
147Spinal muscular atrophy (HP:0007269)1.69033148
148Uterine neoplasm (HP:0010784)1.68749519
149Macroorchidism (HP:0000053)1.68649823
150Abnormality of the lower motor neuron (HP:0002366)1.68548409
151Myelodysplasia (HP:0002863)1.68248753
152Rectal prolapse (HP:0002035)1.68036991
153Hypopigmentation of the fundus (HP:0007894)1.67681348
154Obsessive-compulsive behavior (HP:0000722)1.67506870
155Increased nuchal translucency (HP:0010880)1.67499126
156Short 1st metacarpal (HP:0010034)1.67380019
157Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67380019
158Abnormality of the aortic arch (HP:0012303)1.67108689
159Neoplasm of the small intestine (HP:0100833)1.66883512
160Premature graying of hair (HP:0002216)1.65274340
161Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64402851
162Acute lymphatic leukemia (HP:0006721)1.64173761
163Abnormality of the 4th metacarpal (HP:0010012)1.63896941
164Albinism (HP:0001022)1.63712246
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63595444
166Aneurysm (HP:0002617)1.63288147
167Hepatoblastoma (HP:0002884)1.63234528
168Cutaneous melanoma (HP:0012056)1.63171141
169Wide nose (HP:0000445)1.62943768
170Gastrointestinal atresia (HP:0002589)1.62654227
171Abnormality of the salivary glands (HP:0010286)1.59919327
172Microvesicular hepatic steatosis (HP:0001414)1.59793332
173Fatigue (HP:0012378)1.59568391
174Septate vagina (HP:0001153)1.55747867
175Absent frontal sinuses (HP:0002688)1.54957696
176Prominent nose (HP:0000448)1.54438608
177Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53555770
178Neonatal hypoglycemia (HP:0001998)1.53023541
179Arnold-Chiari malformation (HP:0002308)1.52219202
180Increased connective tissue (HP:0009025)1.52166245
181Renal cell carcinoma (HP:0005584)1.51954009
182Abnormality of the distal phalanx of the thumb (HP:0009617)1.50070967
183Broad palm (HP:0001169)1.49142461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.29993038
2DDR23.75910549
3EEF2K2.99332866
4TRIB32.71138552
5SMG12.61257203
6MAP3K62.52098930
7CDK122.46059599
8PKN22.45272782
9PDGFRA2.43230210
10MAP3K102.37467374
11TYRO32.14449385
12EIF2AK32.13143043
13BMX2.10019052
14MAP3K112.04226254
15CDC72.01450634
16MAPK151.99345193
17SRPK11.91687864
18CDK61.88715284
19EIF2AK11.85889935
20PRPF4B1.83083976
21RPS6KB21.79524649
22PBK1.79381218
23MATK1.77595082
24NEK21.74947778
25CDK71.70529368
26FGR1.63792755
27NEK11.55963185
28MKNK11.51030158
29LATS11.47516128
30DYRK1B1.43570337
31CSK1.37474245
32LATS21.36524030
33MTOR1.35287985
34PIM11.33777119
35FGFR31.32440437
36TAF11.32328059
37EPHA21.29339113
38TRPM71.27061385
39MST1R1.26466075
40PRKD21.26387125
41FLT31.24225112
42WEE11.22686609
43TTN1.20736534
44DAPK11.20349061
45RIPK11.19471433
46STK101.17467905
47SCYL21.15866933
48NEK61.15340183
49ALK1.11999097
50CDK41.11391360
51PIM21.09819582
52UHMK11.07348905
53PLK11.04355738
54LRRK21.04256334
55STK31.01055012
56ATR1.00491933
57CHEK20.99468207
58FGFR20.98553496
59PAK40.98443868
60SIK10.96286986
61PASK0.95657298
62KSR20.94590171
63TTK0.94519161
64RPS6KC10.92342316
65RPS6KL10.92342316
66MAP3K80.92174312
67PAK20.92020889
68PTK60.91128649
69DYRK30.88216547
70MAPK110.87435020
71YES10.87383306
72AURKB0.83681260
73PINK10.81227857
74CHEK10.80570577
75GSK3A0.78591383
76RPS6KA60.78578934
77RET0.77769710
78FGFR10.77765008
79PDGFRB0.77195752
80MAP3K130.76430437
81MAP3K90.75620134
82TGFBR10.74401922
83CAMK1G0.72024537
84CLK10.71973360
85PLK30.71582722
86* CDK20.71546616
87EIF2AK20.66799772
88MAP3K140.65756714
89STK38L0.64334403
90ATM0.61979448
91MAP3K20.61569973
92CDC42BPA0.61550290
93ERBB30.60047000
94MKNK20.59302514
95* RPS6KB10.59126915
96MAP4K10.58047867
97NEK90.58039144
98RPS6KA40.57415843
99PTK20.57361945
100BRD40.57278635
101AKT30.56936693
102BMPR20.56931834
103CAMK1D0.55617636
104BUB10.53172139
105STK240.53153399
106NLK0.52295468
107KSR10.51544323
108MAPKAPK30.51274710
109HIPK20.50459122
110SGK30.49979560
111TSSK60.49944247
112ERN10.47114003
113EGFR0.46385631
114BRSK20.46101272
115STK40.44730104
116MAPK10.44507469
117MAP2K20.42958634
118MELK0.42564123
119CDK10.42403814
120PRKAA10.42179046
121* RPS6KA10.40971274
122AKT20.40622123
123ACVR1B0.38689833
124ERBB40.38353229
125MAPK140.38239346
126MET0.37509851
127RAF10.37129685
128DMPK0.36228403
129AURKA0.35835074
130PLK40.35235235
131WNK10.35084500
132TESK20.35005140
133MAP2K30.34929733
134TAOK10.34599901
135FGFR40.33757562
136TAOK20.33217365
137* MAPK100.31249422
138* CSNK1E0.30387920
139* PRKDC0.29747545
140OBSCN0.29282319

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.90685521
2DNA replication_Homo sapiens_hsa030303.61269521
3Base excision repair_Homo sapiens_hsa034103.23464890
4Fatty acid biosynthesis_Homo sapiens_hsa000612.85266955
5* RNA transport_Homo sapiens_hsa030132.43572592
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35357559
7Spliceosome_Homo sapiens_hsa030402.33848396
8One carbon pool by folate_Homo sapiens_hsa006702.26702094
9mRNA surveillance pathway_Homo sapiens_hsa030152.11146061
10Cell cycle_Homo sapiens_hsa041102.04053136
11Nucleotide excision repair_Homo sapiens_hsa034201.94662747
12Adherens junction_Homo sapiens_hsa045201.78283098
13p53 signaling pathway_Homo sapiens_hsa041151.70485181
14Biosynthesis of amino acids_Homo sapiens_hsa012301.69151645
15Hippo signaling pathway_Homo sapiens_hsa043901.69058385
16Notch signaling pathway_Homo sapiens_hsa043301.68812850
17Lysine degradation_Homo sapiens_hsa003101.60810380
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60265042
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59774347
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57587618
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56685293
22* mTOR signaling pathway_Homo sapiens_hsa041501.52154908
23Bladder cancer_Homo sapiens_hsa052191.45908980
24Chronic myeloid leukemia_Homo sapiens_hsa052201.43653743
25MicroRNAs in cancer_Homo sapiens_hsa052061.41413735
26Homologous recombination_Homo sapiens_hsa034401.35900994
27Small cell lung cancer_Homo sapiens_hsa052221.33097819
28Hedgehog signaling pathway_Homo sapiens_hsa043401.32724499
29Renal cell carcinoma_Homo sapiens_hsa052111.32324220
30Ribosome_Homo sapiens_hsa030101.30398811
31TGF-beta signaling pathway_Homo sapiens_hsa043501.27609224
32Viral carcinogenesis_Homo sapiens_hsa052031.26939367
33Basal cell carcinoma_Homo sapiens_hsa052171.26878713
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23956149
35ErbB signaling pathway_Homo sapiens_hsa040121.17734471
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15734367
37Colorectal cancer_Homo sapiens_hsa052101.15684078
38Inositol phosphate metabolism_Homo sapiens_hsa005621.15229941
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.13702823
40Fanconi anemia pathway_Homo sapiens_hsa034601.12288752
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08551484
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07986927
43Thyroid cancer_Homo sapiens_hsa052161.05683962
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01638777
45Prolactin signaling pathway_Homo sapiens_hsa049171.01259663
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98892131
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97873442
48Selenocompound metabolism_Homo sapiens_hsa004500.97208394
49Viral myocarditis_Homo sapiens_hsa054160.90871345
50HTLV-I infection_Homo sapiens_hsa051660.90573172
51Acute myeloid leukemia_Homo sapiens_hsa052210.89032174
52* Proteoglycans in cancer_Homo sapiens_hsa052050.88165728
53FoxO signaling pathway_Homo sapiens_hsa040680.87996310
54Shigellosis_Homo sapiens_hsa051310.87605388
55Choline metabolism in cancer_Homo sapiens_hsa052310.85343601
56Systemic lupus erythematosus_Homo sapiens_hsa053220.85150454
57Oocyte meiosis_Homo sapiens_hsa041140.83792241
58Focal adhesion_Homo sapiens_hsa045100.83121074
59Arginine and proline metabolism_Homo sapiens_hsa003300.82087988
60Wnt signaling pathway_Homo sapiens_hsa043100.81552226
61VEGF signaling pathway_Homo sapiens_hsa043700.80841747
62Endometrial cancer_Homo sapiens_hsa052130.80393335
63AMPK signaling pathway_Homo sapiens_hsa041520.78825952
64RNA degradation_Homo sapiens_hsa030180.78490925
65Arginine biosynthesis_Homo sapiens_hsa002200.77627376
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.76271215
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76083971
68Tight junction_Homo sapiens_hsa045300.75401423
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75162919
70Alcoholism_Homo sapiens_hsa050340.74910491
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74706607
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.72827509
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72758904
74Sulfur relay system_Homo sapiens_hsa041220.72142562
75Pancreatic cancer_Homo sapiens_hsa052120.69314720
76Melanoma_Homo sapiens_hsa052180.66579850
77Non-small cell lung cancer_Homo sapiens_hsa052230.65854163
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65610427
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65170511
80Epstein-Barr virus infection_Homo sapiens_hsa051690.64911549
81T cell receptor signaling pathway_Homo sapiens_hsa046600.64094461
82Prostate cancer_Homo sapiens_hsa052150.64039033
83Herpes simplex infection_Homo sapiens_hsa051680.63863176
84Fatty acid metabolism_Homo sapiens_hsa012120.63170178
85Insulin signaling pathway_Homo sapiens_hsa049100.63033004
86HIF-1 signaling pathway_Homo sapiens_hsa040660.62966255
87Legionellosis_Homo sapiens_hsa051340.62909563
88Estrogen signaling pathway_Homo sapiens_hsa049150.62623463
89Glucagon signaling pathway_Homo sapiens_hsa049220.61935579
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60964453
91Antigen processing and presentation_Homo sapiens_hsa046120.59076370
92Fructose and mannose metabolism_Homo sapiens_hsa000510.58378278
93Measles_Homo sapiens_hsa051620.57612555
94Hepatitis B_Homo sapiens_hsa051610.57335159
95Circadian rhythm_Homo sapiens_hsa047100.57310240
96N-Glycan biosynthesis_Homo sapiens_hsa005100.57247131
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56549085
98Pathways in cancer_Homo sapiens_hsa052000.55976328
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.55471528
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.52804214
101Nitrogen metabolism_Homo sapiens_hsa009100.52230032
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50802959
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.50609503
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50587664
105Primary immunodeficiency_Homo sapiens_hsa053400.50058078
106Carbon metabolism_Homo sapiens_hsa012000.49973693
107Hepatitis C_Homo sapiens_hsa051600.49550582
108Non-homologous end-joining_Homo sapiens_hsa034500.48727976
109Pyruvate metabolism_Homo sapiens_hsa006200.47358008
110Apoptosis_Homo sapiens_hsa042100.46474306
111Galactose metabolism_Homo sapiens_hsa000520.45920132
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.41562992
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41404797
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41162067
115Thyroid hormone synthesis_Homo sapiens_hsa049180.40973906
116Folate biosynthesis_Homo sapiens_hsa007900.40469930
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.39745559
118Basal transcription factors_Homo sapiens_hsa030220.39148679
119Dorso-ventral axis formation_Homo sapiens_hsa043200.39135351
120Platelet activation_Homo sapiens_hsa046110.38966708
121B cell receptor signaling pathway_Homo sapiens_hsa046620.38609759
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38292144
123Pentose phosphate pathway_Homo sapiens_hsa000300.38099447
124* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37778045
125ECM-receptor interaction_Homo sapiens_hsa045120.37255060
126Insulin resistance_Homo sapiens_hsa049310.35365906
127Glioma_Homo sapiens_hsa052140.34214521

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