ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to exogenous dsRNA (GO:0071360)	6.38458894
2	water-soluble vitamin biosynthetic process (GO:0042364)	5.66170955
3	maturation of 5.8S rRNA (GO:0000460)	5.57165175
4	lipopolysaccharide biosynthetic process (GO:0009103)	5.17305992
5	heparin biosynthetic process (GO:0030210)	5.15420402
6	heparin metabolic process (GO:0030202)	5.15420402
7	lipopolysaccharide metabolic process (GO:0008653)	4.88277140
8	cellular response to ATP (GO:0071318)	4.80496712
9	nucleotide transmembrane transport (GO:1901679)	4.77024072
10	preassembly of GPI anchor in ER membrane (GO:0016254)	4.74418586
11	rRNA methylation (GO:0031167)	4.74297723
12	cellular response to interferon-beta (GO:0035458)	4.64573926
13	aggressive behavior (GO:0002118)	4.46236829
14	rRNA modification (GO:0000154)	4.40368043
15	DNA deamination (GO:0045006)	4.13937531
16	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.01727422
17	proteasome assembly (GO:0043248)	3.94096697
18	positive regulation of digestive system process (GO:0060456)	3.93518298
19	pseudouridine synthesis (GO:0001522)	3.87141241
20	maternal behavior (GO:0042711)	3.83476998
21	GPI anchor metabolic process (GO:0006505)	3.81825776
22	pyrimidine dimer repair (GO:0006290)	3.78010370
23	regulation of penile erection (GO:0060405)	3.70529788
24	positive regulation of prostaglandin secretion (GO:0032308)	3.67109115
25	cellular response to dsRNA (GO:0071359)	3.63101933
26	telomere maintenance via telomerase (GO:0007004)	3.55774476
27	L-methionine salvage (GO:0071267)	3.55303459
28	L-methionine biosynthetic process (GO:0071265)	3.55303459
29	amino acid salvage (GO:0043102)	3.55303459
30	ubiquinone biosynthetic process (GO:0006744)	3.54833996
31	reciprocal DNA recombination (GO:0035825)	3.49913082
32	reciprocal meiotic recombination (GO:0007131)	3.49913082
33	regulation of interferon-beta biosynthetic process (GO:0045357)	3.49541233
34	parental behavior (GO:0060746)	3.46641526
35	regulation of female receptivity (GO:0045924)	3.44559806
36	female mating behavior (GO:0060180)	3.42993321
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41720060
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41720060
39	cellular ketone body metabolic process (GO:0046950)	3.38731165
40	phosphatidylethanolamine metabolic process (GO:0046337)	3.30859687
41	sleep (GO:0030431)	3.22477341
42	fucose catabolic process (GO:0019317)	3.18730680
43	L-fucose metabolic process (GO:0042354)	3.18730680
44	L-fucose catabolic process (GO:0042355)	3.18730680
45	mitochondrial RNA metabolic process (GO:0000959)	3.18000050
46	GPI anchor biosynthetic process (GO:0006506)	3.17105103
47	positive regulation of fatty acid transport (GO:2000193)	3.12839493
48	microglial cell activation (GO:0001774)	3.10033502
49	regulation of glomerulus development (GO:0090192)	3.08173146
50	sulfation (GO:0051923)	3.07643598
51	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.07417526
52	behavioral response to nicotine (GO:0035095)	3.05314595
53	ribosome assembly (GO:0042255)	3.05292226
54	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.03728503
55	regulation of helicase activity (GO:0051095)	3.03587940
56	synaptonemal complex assembly (GO:0007130)	3.03248659
57	mRNA cleavage (GO:0006379)	3.00766119
58	regulation of prostaglandin secretion (GO:0032306)	2.99805729
59	ubiquinone metabolic process (GO:0006743)	2.98901310
60	ketone body metabolic process (GO:1902224)	2.95277818
61	response to interferon-beta (GO:0035456)	2.93061222
62	organic cation transport (GO:0015695)	2.92328306
63	mitochondrial DNA replication (GO:0006264)	2.90381063
64	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.88847676
65	modulation by symbiont of host immune response (GO:0052553)	2.88847676
66	positive regulation by symbiont of host defense response (GO:0052509)	2.88847676
67	modulation by symbiont of host defense response (GO:0052031)	2.88847676
68	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.88847676
69	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.88847676
70	quinone biosynthetic process (GO:1901663)	2.88136155
71	anterograde synaptic vesicle transport (GO:0048490)	2.87942334
72	kynurenine metabolic process (GO:0070189)	2.84761276
73	retinal cone cell development (GO:0046549)	2.83250469
74	negative regulation of mast cell activation (GO:0033004)	2.81665195
75	C-terminal protein lipidation (GO:0006501)	2.80962987
76	nucleotide transport (GO:0006862)	2.80730619
77	response to ATP (GO:0033198)	2.79592259
78	RNA methylation (GO:0001510)	2.78138921
79	positive regulation of interferon-alpha production (GO:0032727)	2.77853861
80	seminiferous tubule development (GO:0072520)	2.75957926
81	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.75768479
82	synaptonemal complex organization (GO:0070193)	2.75706902
83	tRNA processing (GO:0008033)	2.73616604
84	positive regulation of icosanoid secretion (GO:0032305)	2.73260678
85	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72294610
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72294610
87	replication fork processing (GO:0031297)	2.71694623
88	tRNA modification (GO:0006400)	2.69567012
89	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.68505752
90	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.68054225
91	amyloid precursor protein catabolic process (GO:0042987)	2.67076372
92	regulation of interferon-alpha production (GO:0032647)	2.66976697
93	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.66845685
94	intra-S DNA damage checkpoint (GO:0031573)	2.64648990
95	heme transport (GO:0015886)	2.64024328
96	C-terminal protein amino acid modification (GO:0018410)	2.63836351
97	I-kappaB phosphorylation (GO:0007252)	2.63667022
98	negative regulation of T cell apoptotic process (GO:0070233)	2.60582780
99	ribosomal large subunit biogenesis (GO:0042273)	2.56805432
100	tRNA methylation (GO:0030488)	2.55616473

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.29413721
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.11732009
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.28562707
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26630967
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.03757382
6	VDR_22108803_ChIP-Seq_LS180_Human	2.99678012
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.94266552
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.80433029
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.69966892
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59151415
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.48674670
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46311380
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.45483378
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35128493
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32286611
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31267555
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20945699
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19421553
19	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.19155580
20	FUS_26573619_Chip-Seq_HEK293_Human	2.19136370
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09945718
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08532423
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05277400
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.00225225
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86558251
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85948697
27	EWS_26573619_Chip-Seq_HEK293_Human	1.85336219
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.83303787
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.83292782
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.82530137
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81986721
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.80561665
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77654923
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.73528671
35	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.64769753
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63260363
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54018463
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.54018463
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53922231
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50630812
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.50269130
42	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.50060002
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45439219
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41386384
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41386384
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40238549
47	P300_19829295_ChIP-Seq_ESCs_Human	1.39184767
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.39082888
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.38642632
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35329466
51	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.33451991
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32056725
53	GBX2_23144817_ChIP-Seq_PC3_Human	1.29638730
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.27055856
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25575900
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.20274721
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19360834
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15047999
59	TCF4_23295773_ChIP-Seq_U87_Human	1.14564756
60	AR_20517297_ChIP-Seq_VCAP_Human	1.13251483
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12401426
62	NCOR_22424771_ChIP-Seq_293T_Human	1.11643090
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10985244
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09760642
65	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.09741055
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.09596754
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08363275
68	STAT3_23295773_ChIP-Seq_U87_Human	1.07700325
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07118926
70	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.07104413
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07020208
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.05202495
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04746460
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04356285
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03281741
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03281741
77	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.02789686
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01590892
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01320844
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98509666
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.95818424
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93883846
83	TTF2_22483619_ChIP-Seq_HELA_Human	0.93464691
84	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.93432142
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92850947
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92156269
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91328091
88	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.90735649
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90678558
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.90450395
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90114937
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.89827375
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89173887
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89031005
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.88671240
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.88583561
97	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87940507
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86620351
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.86422099
100	SPI1_23547873_ChIP-Seq_NB4_Human	0.86217080

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	4.08105842
2	MP0002138_abnormal_hepatobiliary_system	3.99531191
3	MP0005084_abnormal_gallbladder_morpholo	3.89863498
4	MP0004145_abnormal_muscle_electrophysio	3.09910736
5	MP0001661_extended_life_span	2.99137300
6	MP0002396_abnormal_hematopoietic_system	2.97917527
7	MP0008058_abnormal_DNA_repair	2.92254385
8	MP0010234_abnormal_vibrissa_follicle	2.92006962
9	MP0002928_abnormal_bile_duct	2.72912249
10	MP0003252_abnormal_bile_duct	2.69419955
11	MP0004134_abnormal_chest_morphology	2.56536474
12	MP0006035_abnormal_mitochondrial_morpho	2.29594754
13	MP0004147_increased_porphyrin_level	2.26798656
14	MP0003195_calcinosis	2.12819128
15	MP0003045_fibrosis	1.95377538
16	MP0003656_abnormal_erythrocyte_physiolo	1.86784441
17	MP0003724_increased_susceptibility_to	1.83540865
18	MP0001986_abnormal_taste_sensitivity	1.76892111
19	MP0005167_abnormal_blood-brain_barrier	1.76180028
20	MP0005551_abnormal_eye_electrophysiolog	1.69113688
21	MP0001502_abnormal_circadian_rhythm	1.67549872
22	MP0009053_abnormal_anal_canal	1.64813438
23	MP0005174_abnormal_tail_pigmentation	1.62027553
24	MP0008872_abnormal_physiological_respon	1.61363332
25	MP0000569_abnormal_digit_pigmentation	1.55623386
26	MP0002160_abnormal_reproductive_system	1.51310887
27	MP0005646_abnormal_pituitary_gland	1.48768205
28	MP0006036_abnormal_mitochondrial_physio	1.47657085
29	MP0004270_analgesia	1.46580443
30	MP0005645_abnormal_hypothalamus_physiol	1.42584136
31	MP0003866_abnormal_defecation	1.36330644
32	MP0002638_abnormal_pupillary_reflex	1.32274471
33	MP0005367_renal/urinary_system_phenotyp	1.31116046
34	MP0000516_abnormal_urinary_system	1.31116046
35	MP0000427_abnormal_hair_cycle	1.29271067
36	MP0008877_abnormal_DNA_methylation	1.26071673
37	MP0004185_abnormal_adipocyte_glucose	1.24447749
38	MP0002148_abnormal_hypersensitivity_rea	1.23825656
39	MP0002822_catalepsy	1.19499185
40	MP0002733_abnormal_thermal_nociception	1.19090833
41	MP0009697_abnormal_copulation	1.17850631
42	MP0002006_tumorigenesis	1.15222492
43	MP0005085_abnormal_gallbladder_physiolo	1.13080067
44	MP0001853_heart_inflammation	1.12668007
45	MP0002139_abnormal_hepatobiliary_system	1.12358248
46	MP0001968_abnormal_touch/_nociception	1.11474873
47	MP0004381_abnormal_hair_follicle	1.08792466
48	MP0006072_abnormal_retinal_apoptosis	1.08052239
49	MP0005083_abnormal_biliary_tract	1.06821843
50	MP0003786_premature_aging	1.06502380
51	MP0004043_abnormal_pH_regulation	1.05699415
52	MP0005365_abnormal_bile_salt	1.03210764
53	MP0000015_abnormal_ear_pigmentation	1.01449288
54	MP0001835_abnormal_antigen_presentation	1.01350989
55	MP0002272_abnormal_nervous_system	0.99644285
56	MP0001800_abnormal_humoral_immune	0.98531311
57	MP0005389_reproductive_system_phenotype	0.97607950
58	MP0004130_abnormal_muscle_cell	0.97527758
59	MP0002452_abnormal_antigen_presenting	0.97492484
60	MP0000467_abnormal_esophagus_morphology	0.96224922
61	MP0004885_abnormal_endolymph	0.95038220
62	MP0005670_abnormal_white_adipose	0.94874606
63	MP0008875_abnormal_xenobiotic_pharmacok	0.94562906
64	MP0005464_abnormal_platelet_physiology	0.94126947
65	MP0001929_abnormal_gametogenesis	0.93146584
66	MP0000230_abnormal_systemic_arterial	0.91723287
67	MP0005220_abnormal_exocrine_pancreas	0.91451570
68	MP0002095_abnormal_skin_pigmentation	0.90307100
69	MP0002693_abnormal_pancreas_physiology	0.89478950
70	MP0003011_delayed_dark_adaptation	0.88713101
71	MP0002166_altered_tumor_susceptibility	0.87320550
72	MP0005253_abnormal_eye_physiology	0.86834800
73	MP0003303_peritoneal_inflammation	0.86241831
74	MP0001790_abnormal_immune_system	0.83962594
75	MP0005387_immune_system_phenotype	0.83962594
76	MP0009745_abnormal_behavioral_response	0.83476297
77	MP0006276_abnormal_autonomic_nervous	0.83284671
78	MP0005410_abnormal_fertilization	0.81902292
79	MP0002837_dystrophic_cardiac_calcinosis	0.79936081
80	MP0009785_altered_susceptibility_to	0.79526344
81	MP0003718_maternal_effect	0.77775233
82	MP0005310_abnormal_salivary_gland	0.77242713
83	MP0003633_abnormal_nervous_system	0.76751004
84	MP0005636_abnormal_mineral_homeostasis	0.76062068
85	MP0002723_abnormal_immune_serum	0.73768777
86	MP0010329_abnormal_lipoprotein_level	0.73741113
87	MP0001485_abnormal_pinna_reflex	0.73651279
88	MP0002102_abnormal_ear_morphology	0.72369978
89	MP0002734_abnormal_mechanical_nocicepti	0.72184654
90	MP0009250_abnormal_appendicular_skeleto	0.72141485
91	MP0010678_abnormal_skin_adnexa	0.71298257
92	MP0005000_abnormal_immune_tolerance	0.70154017
93	MP0000689_abnormal_spleen_morphology	0.69955713
94	MP0002420_abnormal_adaptive_immunity	0.68287005
95	MP0003172_abnormal_lysosome_physiology	0.66714983
96	MP0002735_abnormal_chemical_nociception	0.66083483
97	MP0008873_increased_physiological_sensi	0.66075620
98	MP0001819_abnormal_immune_cell	0.65409834
99	MP0003638_abnormal_response/metabolism_	0.65385972
100	MP0000358_abnormal_cell_content/	0.62658609

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	6.16443272
2	Large for gestational age (HP:0001520)	5.35445534
3	Pendular nystagmus (HP:0012043)	5.07381235
4	Duplicated collecting system (HP:0000081)	3.69258902
5	Pancreatic cysts (HP:0001737)	3.53969454
6	Panhypogammaglobulinemia (HP:0003139)	3.52549773
7	Abnormality of the renal collecting system (HP:0004742)	3.52268611
8	Abnormality of the pons (HP:0007361)	3.42473950
9	Agnosia (HP:0010524)	3.33602524
10	Methylmalonic acidemia (HP:0002912)	3.25361612
11	Hypoproteinemia (HP:0003075)	3.24027074
12	Constricted visual fields (HP:0001133)	3.11518929
13	Abnormality of B cell number (HP:0010975)	3.11255291
14	Pancreatic fibrosis (HP:0100732)	3.07859845
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02198451
16	Premature ovarian failure (HP:0008209)	3.01892875
17	Methylmalonic aciduria (HP:0012120)	2.95195977
18	True hermaphroditism (HP:0010459)	2.93983098
19	Agitation (HP:0000713)	2.90207839
20	Confusion (HP:0001289)	2.88324821
21	B lymphocytopenia (HP:0010976)	2.87869118
22	Abolished electroretinogram (ERG) (HP:0000550)	2.86801603
23	Oral leukoplakia (HP:0002745)	2.84606448
24	Ependymoma (HP:0002888)	2.84242924
25	Ketoacidosis (HP:0001993)	2.81287019
26	Attenuation of retinal blood vessels (HP:0007843)	2.78973914
27	Genetic anticipation (HP:0003743)	2.64385767
28	Thyroiditis (HP:0100646)	2.62706449
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.61827433
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.61827433
31	Conjunctival hamartoma (HP:0100780)	2.61051171
32	Absent phalangeal crease (HP:0006109)	2.59830966
33	Progressive inability to walk (HP:0002505)	2.57523031
34	Furrowed tongue (HP:0000221)	2.53260176
35	Abnormal biliary tract physiology (HP:0012439)	2.48788243
36	Bile duct proliferation (HP:0001408)	2.48788243
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.47462161
38	Nephronophthisis (HP:0000090)	2.37666867
39	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.35855168
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34554533
41	Squamous cell carcinoma (HP:0002860)	2.33664694
42	Severe combined immunodeficiency (HP:0004430)	2.25628616
43	Abnormality of binocular vision (HP:0011514)	2.23801038
44	Diplopia (HP:0000651)	2.23801038
45	Cutaneous melanoma (HP:0012056)	2.22125800
46	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.18552117
47	Abnormality of the renal cortex (HP:0011035)	2.17908506
48	Hamartoma of the eye (HP:0010568)	2.16977477
49	Keratoconus (HP:0000563)	2.15953662
50	Increased corneal curvature (HP:0100692)	2.15953662
51	Gonadotropin excess (HP:0000837)	2.13714081
52	Congenital stationary night blindness (HP:0007642)	2.13100395
53	Increased serum lactate (HP:0002151)	2.12524650
54	Hypochromic microcytic anemia (HP:0004840)	2.11697789
55	Type I transferrin isoform profile (HP:0003642)	2.06588363
56	Abnormality of the renal medulla (HP:0100957)	2.06301132
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05970543
58	Dicarboxylic aciduria (HP:0003215)	2.05970543
59	Abnormality of vitamin B metabolism (HP:0004340)	2.05678256
60	Hypothermia (HP:0002045)	2.05096231
61	Eosinophilia (HP:0001880)	2.04665663
62	Posterior subcapsular cataract (HP:0007787)	2.04367010
63	Inability to walk (HP:0002540)	2.03349427
64	Abnormal finger flexion creases (HP:0006143)	1.97512944
65	Abnormality of the 4th metacarpal (HP:0010012)	1.96378602
66	Hemiplegia (HP:0002301)	1.96031141
67	Azoospermia (HP:0000027)	1.93862180
68	Astrocytoma (HP:0009592)	1.93582994
69	Abnormality of the astrocytes (HP:0100707)	1.93582994
70	Neoplasm of the adrenal cortex (HP:0100641)	1.93329343
71	Tinnitus (HP:0000360)	1.91551469
72	Cortical visual impairment (HP:0100704)	1.91422928
73	Basal cell carcinoma (HP:0002671)	1.91119073
74	Chronic hepatic failure (HP:0100626)	1.89105431
75	CNS hypomyelination (HP:0003429)	1.88969340
76	Decreased central vision (HP:0007663)	1.88386490
77	Visual hallucinations (HP:0002367)	1.85246894
78	Unilateral renal agenesis (HP:0000122)	1.82060449
79	Ketosis (HP:0001946)	1.82040984
80	Cystic liver disease (HP:0006706)	1.81544266
81	Autoimmune thrombocytopenia (HP:0001973)	1.79008028
82	Abnormal protein glycosylation (HP:0012346)	1.77102380
83	Abnormal glycosylation (HP:0012345)	1.77102380
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77102380
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.77102380
86	Abnormality of chromosome stability (HP:0003220)	1.76736941
87	Short 1st metacarpal (HP:0010034)	1.75045572
88	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.75045572
89	Decreased circulating renin level (HP:0003351)	1.74702198
90	Glioma (HP:0009733)	1.72523505
91	Progressive muscle weakness (HP:0003323)	1.72247033
92	Abnormality of macular pigmentation (HP:0008002)	1.70906345
93	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.70323532
94	Hypoplasia of the fovea (HP:0007750)	1.70323532
95	Progressive cerebellar ataxia (HP:0002073)	1.67550746
96	Molar tooth sign on MRI (HP:0002419)	1.65763134
97	Abnormality of midbrain morphology (HP:0002418)	1.65763134
98	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.65501724
99	Abnormal spermatogenesis (HP:0008669)	1.64603379
100	Seborrheic dermatitis (HP:0001051)	1.64442350

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.91310577
2	TAOK3	3.95331472
3	VRK2	3.00277152
4	NUAK1	2.70621382
5	STK38L	2.66333470
6	MKNK1	2.64018319
7	TSSK6	2.56999149
8	PINK1	2.38058352
9	TLK1	2.37820664
10	PDK2	2.33481923
11	CCNB1	2.19562683
12	GRK1	2.08433675
13	CSNK1A1L	2.06285196
14	ADRBK2	2.04548987
15	CSNK1G3	2.02599637
16	CSNK1G1	1.91551513
17	EIF2AK3	1.91309118
18	MKNK2	1.88791026
19	PIK3CG	1.88067059
20	TXK	1.69763173
21	INSRR	1.68939896
22	BMPR1B	1.56696038
23	MAPKAPK5	1.55385360
24	TRIM28	1.54432957
25	JAK3	1.50840778
26	PRKD2	1.50087174
27	VRK1	1.47774911
28	CSNK1G2	1.47682576
29	ACVR1B	1.44231637
30	CDK19	1.35752539
31	ITK	1.31840479
32	MAP4K2	1.31364239
33	BUB1	1.30093227
34	MST4	1.25530568
35	ZAK	1.24986824
36	TNIK	1.20824222
37	MAP4K1	1.09388902
38	TEC	1.08434524
39	PHKG1	1.06400133
40	PHKG2	1.06400133
41	STK24	1.03700336
42	IRAK1	1.02094202
43	FGFR2	1.00938129
44	PLK3	0.97017884
45	RPS6KA5	0.92078031
46	SYK	0.91245674
47	SRPK1	0.90945771
48	IKBKB	0.89561122
49	LATS1	0.85950662
50	IRAK2	0.83140543
51	STK3	0.67793673
52	PRKCI	0.67098031
53	RIPK4	0.67025847
54	FLT3	0.66248443
55	PAK3	0.65817237
56	PRKCQ	0.65191452
57	PAK6	0.64450448
58	PIK3CA	0.61925793
59	MAP2K6	0.61631976
60	FGFR3	0.61556175
61	FES	0.60599008
62	LCK	0.59961917
63	TIE1	0.58441723
64	BTK	0.57875818
65	MAP3K9	0.57304396
66	LYN	0.56830758
67	NEK1	0.56461307
68	RPS6KB1	0.55553554
69	KIT	0.54734523
70	CDK8	0.52627955
71	PRKCH	0.50073969
72	RPS6KA4	0.47697959
73	PLK2	0.46861672
74	WNK4	0.45196186
75	PASK	0.45103487
76	STK38	0.43441919
77	CDK9	0.43375168
78	IGF1R	0.42439943
79	PRKCE	0.39946891
80	ATR	0.39726276
81	MAP2K1	0.39321492
82	CSNK1D	0.38536622
83	RPS6KA6	0.38111757
84	RAF1	0.37812603
85	TGFBR1	0.37617491
86	FGFR1	0.37338380
87	ALK	0.35690828
88	FGR	0.35341229
89	GRK6	0.35317530
90	TAF1	0.34912872
91	ZAP70	0.33238572
92	NLK	0.31875092
93	CSF1R	0.31813912
94	STK16	0.28213333
95	RPS6KL1	0.27184044
96	RPS6KC1	0.27184044
97	ATM	0.26906543
98	PTK2B	0.26894440
99	PRKDC	0.26288020
100	PRKCG	0.25905878

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.23334303
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.01631007
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.45220795
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.37202615
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.33517694
6	Homologous recombination_Homo sapiens_hsa03440	2.22855979
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.20242314
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.14273881
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.14123022
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.05320544
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04249587
12	RNA polymerase_Homo sapiens_hsa03020	1.92405689
13	Collecting duct acid secretion_Homo sapiens_hsa04966	1.90739465
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.82313920
15	Proteasome_Homo sapiens_hsa03050	1.81702207
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.81076610
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.77971518
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.76817735
19	Basal transcription factors_Homo sapiens_hsa03022	1.69293248
20	Propanoate metabolism_Homo sapiens_hsa00640	1.69069664
21	Asthma_Homo sapiens_hsa05310	1.68639119
22	Glycerolipid metabolism_Homo sapiens_hsa00561	1.68171956
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.63462875
24	Olfactory transduction_Homo sapiens_hsa04740	1.59762568
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.59449163
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55837249
27	Allograft rejection_Homo sapiens_hsa05330	1.53850414
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.49440081
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.46132866
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.44868092
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40856993
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40146451
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.35946895
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35930310
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32879840
36	One carbon pool by folate_Homo sapiens_hsa00670	1.30436179
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28371427
38	Peroxisome_Homo sapiens_hsa04146	1.22538109
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16712428
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.06417280
41	Taste transduction_Homo sapiens_hsa04742	1.05554938
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04980818
43	RNA transport_Homo sapiens_hsa03013	1.03465486
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02379115
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.00605364
46	Nicotine addiction_Homo sapiens_hsa05033	1.00006791
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99953022
48	DNA replication_Homo sapiens_hsa03030	0.98810652
49	Parkinsons disease_Homo sapiens_hsa05012	0.97552204
50	ABC transporters_Homo sapiens_hsa02010	0.89241793
51	Protein export_Homo sapiens_hsa03060	0.88033881
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86378934
53	Purine metabolism_Homo sapiens_hsa00230	0.85085151
54	Alzheimers disease_Homo sapiens_hsa05010	0.84910051
55	Sulfur metabolism_Homo sapiens_hsa00920	0.84540485
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.81287836
57	RNA degradation_Homo sapiens_hsa03018	0.81025069
58	Butanoate metabolism_Homo sapiens_hsa00650	0.81024138
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.80691529
60	Fatty acid degradation_Homo sapiens_hsa00071	0.77664370
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73678560
62	Measles_Homo sapiens_hsa05162	0.73488802
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71165184
64	Spliceosome_Homo sapiens_hsa03040	0.71103685
65	Long-term depression_Homo sapiens_hsa04730	0.70613670
66	Mismatch repair_Homo sapiens_hsa03430	0.66620441
67	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.66519860
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61304317
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57506957
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56923160
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55854772
72	Phototransduction_Homo sapiens_hsa04744	0.55046673
73	Metabolic pathways_Homo sapiens_hsa01100	0.54164186
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49079595
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.48540259
76	Huntingtons disease_Homo sapiens_hsa05016	0.48130748
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47610970
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47265353
79	Histidine metabolism_Homo sapiens_hsa00340	0.47162536
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45218709
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.45145299
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43788788
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43349074
84	Herpes simplex infection_Homo sapiens_hsa05168	0.42248551
85	Caffeine metabolism_Homo sapiens_hsa00232	0.40401676
86	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40039980
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39588042
88	Renin secretion_Homo sapiens_hsa04924	0.38702696
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37414383
90	Melanoma_Homo sapiens_hsa05218	0.35428455
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34646268
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32606235
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31795363
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31104627
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29133963
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.28062561
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26736703
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.24818667
99	Platelet activation_Homo sapiens_hsa04611	0.24576549
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.23758576

EIF4BP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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