ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of T cell cytokine production (GO:0002726)	4.69786624
2	regulation of isotype switching to IgG isotypes (GO:0048302)	4.35877072
3	ubiquinone metabolic process (GO:0006743)	4.33379106
4	mitochondrial respiratory chain complex assembly (GO:0033108)	4.29294283
5	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.29047241
6	protein complex biogenesis (GO:0070271)	4.28920078
7	positive regulation of protein homodimerization activity (GO:0090073)	4.21560036
8	regulation of immunoglobulin secretion (GO:0051023)	3.91440537
9	DNA deamination (GO:0045006)	3.78509704
10	tachykinin receptor signaling pathway (GO:0007217)	3.76542670
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76245863
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76245863
13	NADH dehydrogenase complex assembly (GO:0010257)	3.76245863
14	mitochondrial calcium ion transport (GO:0006851)	3.76192912
15	chaperone-mediated protein transport (GO:0072321)	3.73125668
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.68301511
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.66357101
18	regulation of uterine smooth muscle contraction (GO:0070472)	3.59918621
19	negative regulation of mast cell activation (GO:0033004)	3.49294995
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.49012291
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.47068508
22	proteasome assembly (GO:0043248)	3.40033271
23	DNA damage response, detection of DNA damage (GO:0042769)	3.37278306
24	glucosamine-containing compound catabolic process (GO:1901072)	3.36584312
25	histone H2A acetylation (GO:0043968)	3.31508930
26	ribosome assembly (GO:0042255)	3.30868458
27	regulation of mitochondrial translation (GO:0070129)	3.23755158
28	cellular ketone body metabolic process (GO:0046950)	3.22155950
29	metallo-sulfur cluster assembly (GO:0031163)	3.21545568
30	iron-sulfur cluster assembly (GO:0016226)	3.21545568
31	regulation of feeding behavior (GO:0060259)	3.11642334
32	tRNA processing (GO:0008033)	3.11352726
33	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.06638208
34	mitochondrial RNA metabolic process (GO:0000959)	3.04008424
35	pseudouridine synthesis (GO:0001522)	2.95184661
36	RNA destabilization (GO:0050779)	2.94371633
37	histone H4-K12 acetylation (GO:0043983)	2.93581296
38	protein neddylation (GO:0045116)	2.92231409
39	binding of sperm to zona pellucida (GO:0007339)	2.90020570
40	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.89354085
41	negative T cell selection (GO:0043383)	2.87859900
42	heparin metabolic process (GO:0030202)	2.86954677
43	heparin biosynthetic process (GO:0030210)	2.86954677
44	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.86649468
45	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.86155913
46	tRNA modification (GO:0006400)	2.84384933
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83564332
48	protein K63-linked ubiquitination (GO:0070534)	2.83292096
49	protein targeting to mitochondrion (GO:0006626)	2.83050620
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.83018707
51	sperm-egg recognition (GO:0035036)	2.82173989
52	ketone body metabolic process (GO:1902224)	2.80762571
53	ATP synthesis coupled proton transport (GO:0015986)	2.80483686
54	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.80483686
55	DNA replication-dependent nucleosome assembly (GO:0006335)	2.80079737
56	DNA replication-dependent nucleosome organization (GO:0034723)	2.80079737
57	tRNA methylation (GO:0030488)	2.79879895
58	termination of RNA polymerase III transcription (GO:0006386)	2.79277765
59	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79277765
60	protein localization to mitochondrion (GO:0070585)	2.79094424
61	de novo posttranslational protein folding (GO:0051084)	2.78246118
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77417395
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77417395
64	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.73487767
65	L-methionine salvage (GO:0071267)	2.73400775
66	L-methionine biosynthetic process (GO:0071265)	2.73400775
67	amino acid salvage (GO:0043102)	2.73400775
68	positive regulation of T-helper 1 type immune response (GO:0002827)	2.73393913
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.73386059
70	tRNA metabolic process (GO:0006399)	2.73305812
71	adenosine metabolic process (GO:0046085)	2.73144049
72	de novo protein folding (GO:0006458)	2.71856983
73	RNA phosphodiester bond hydrolysis (GO:0090501)	2.71681167
74	rRNA catabolic process (GO:0016075)	2.69765640
75	regulation of T cell cytokine production (GO:0002724)	2.69479896
76	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.68206056
77	cytochrome complex assembly (GO:0017004)	2.66883640
78	purine-containing compound salvage (GO:0043101)	2.66076178
79	spliceosomal snRNP assembly (GO:0000387)	2.66018369
80	ubiquinone biosynthetic process (GO:0006744)	2.64999034
81	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.64030707
82	AMP metabolic process (GO:0046033)	2.62332233
83	replication fork processing (GO:0031297)	2.61687502
84	GMP metabolic process (GO:0046037)	2.60190607
85	establishment of protein localization to mitochondrion (GO:0072655)	2.60104441
86	sulfation (GO:0051923)	2.59787408
87	peptidyl-histidine modification (GO:0018202)	2.57454076
88	neural tube formation (GO:0001841)	2.56739035
89	postreplication repair (GO:0006301)	2.55676809
90	maturation of 5.8S rRNA (GO:0000460)	2.55283144
91	cullin deneddylation (GO:0010388)	2.55156396
92	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.54807076
93	transcription from RNA polymerase III promoter (GO:0006383)	2.53771335
94	inner mitochondrial membrane organization (GO:0007007)	2.52858076
95	branched-chain amino acid catabolic process (GO:0009083)	2.51255326
96	protein deneddylation (GO:0000338)	2.51026375
97	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.50120514
98	aspartate family amino acid catabolic process (GO:0009068)	2.49721705
99	positive regulation of cell fate commitment (GO:0010455)	2.48489472
100	glucosamine-containing compound metabolic process (GO:1901071)	2.48447844

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.24748379
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.63487917
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.54403919
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.53916351
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.21185130
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.12059059
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08247490
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03642679
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91607329
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.89874304
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88849062
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.86177573
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.84221522
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70936565
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.49891020
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.47423556
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.19779122
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.99201393
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96157375
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93133292
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.84640011
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.81758480
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.79678753
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79573763
25	VDR_22108803_ChIP-Seq_LS180_Human	1.75909003
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71964764
27	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.68220053
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67384555
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.66030039
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.63082103
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.61881493
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59703631
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59364403
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56691426
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.56103900
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50818031
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50773176
38	EWS_26573619_Chip-Seq_HEK293_Human	1.47056285
39	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45082152
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.41824359
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.39333094
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.38800658
43	CIITA_25753668_ChIP-Seq_RAJI_Human	1.38022447
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.37096876
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37096876
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.36989287
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.36760216
48	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.36087105
49	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.34669121
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34289357
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33340390
52	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32665578
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31053196
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30767598
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.24081424
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.22414946
57	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.21100829
58	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.16060240
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.15347592
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10942800
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09718518
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.09421580
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.08887891
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.08884195
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.08083275
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07866145
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07055196
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07055196
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06851926
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.06014718
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.05536292
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03609494
73	P300_19829295_ChIP-Seq_ESCs_Human	1.02935883
74	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02778099
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02728779
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01955673
77	TAF15_26573619_Chip-Seq_HEK293_Human	0.99810111
78	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99544437
79	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99544437
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99043420
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98712806
82	NCOR_22424771_ChIP-Seq_293T_Human	0.98236632
83	GATA3_26560356_Chip-Seq_TH2_Human	0.98208624
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.98163231
85	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97696956
86	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.93164722
87	ERG_20517297_ChIP-Seq_VCAP_Human	0.91561516
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.91078261
89	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89593037
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87926179
91	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.87697607
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.85464044
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.85307608
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.83492565
95	TFEB_21752829_ChIP-Seq_HELA_Human	0.83270242
96	FUS_26573619_Chip-Seq_HEK293_Human	0.82443867
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82349161
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.82327226
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.81894997
100	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.81018007

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.70205244
2	MP0002102_abnormal_ear_morphology	3.65500370
3	MP0008875_abnormal_xenobiotic_pharmacok	3.32137357
4	MP0001188_hyperpigmentation	3.17647772
5	MP0002138_abnormal_hepatobiliary_system	2.82880099
6	MP0005646_abnormal_pituitary_gland	2.80626161
7	MP0002277_abnormal_respiratory_mucosa	2.79112155
8	MP0005645_abnormal_hypothalamus_physiol	2.78310808
9	MP0001348_abnormal_lacrimal_gland	2.49958365
10	MP0003786_premature_aging	2.38638199
11	MP0002876_abnormal_thyroid_physiology	2.36154248
12	MP0001529_abnormal_vocalization	2.31668071
13	MP0006292_abnormal_olfactory_placode	2.30375736
14	MP0003806_abnormal_nucleotide_metabolis	1.98349436
15	MP0009379_abnormal_foot_pigmentation	1.94223990
16	MP0005084_abnormal_gallbladder_morpholo	1.93197017
17	MP0008058_abnormal_DNA_repair	1.92333461
18	MP0001905_abnormal_dopamine_level	1.87674339
19	MP0000569_abnormal_digit_pigmentation	1.82249918
20	MP0003718_maternal_effect	1.79716707
21	MP0009840_abnormal_foam_cell	1.78996752
22	MP0002736_abnormal_nociception_after	1.76396885
23	MP0001968_abnormal_touch/_nociception	1.73532217
24	MP0002234_abnormal_pharynx_morphology	1.60320471
25	MP0003693_abnormal_embryo_hatching	1.54752253
26	MP0003195_calcinosis	1.54547403
27	MP0005671_abnormal_response_to	1.51797893
28	MP0008007_abnormal_cellular_replicative	1.43636804
29	MP0002139_abnormal_hepatobiliary_system	1.42015601
30	MP0000383_abnormal_hair_follicle	1.41415643
31	MP0000647_abnormal_sebaceous_gland	1.37211227
32	MP0000631_abnormal_neuroendocrine_gland	1.34396068
33	MP0004145_abnormal_muscle_electrophysio	1.33860330
34	MP0001764_abnormal_homeostasis	1.32897778
35	MP0002837_dystrophic_cardiac_calcinosis	1.31125941
36	MP0005085_abnormal_gallbladder_physiolo	1.30742419
37	MP0004924_abnormal_behavior	1.29732072
38	MP0005386_behavior/neurological_phenoty	1.29732072
39	MP0006072_abnormal_retinal_apoptosis	1.27318591
40	MP0002163_abnormal_gland_morphology	1.21885635
41	MP0009697_abnormal_copulation	1.20242871
42	MP0010094_abnormal_chromosome_stability	1.19070265
43	MP0008872_abnormal_physiological_respon	1.18195918
44	MP0002735_abnormal_chemical_nociception	1.14540817
45	MP0002160_abnormal_reproductive_system	1.12139861
46	MP0001293_anophthalmia	1.08230598
47	MP0008995_early_reproductive_senescence	1.07928640
48	MP0002557_abnormal_social/conspecific_i	1.07911922
49	MP0004133_heterotaxia	1.05524112
50	MP0003252_abnormal_bile_duct	1.04822992
51	MP0003011_delayed_dark_adaptation	1.04523364
52	MP0003763_abnormal_thymus_physiology	1.03748992
53	MP0009745_abnormal_behavioral_response	1.02685102
54	MP0005551_abnormal_eye_electrophysiolog	1.01737787
55	MP0003866_abnormal_defecation	1.00333790
56	MP0004885_abnormal_endolymph	0.98502523
57	MP0002148_abnormal_hypersensitivity_rea	0.98160770
58	MP0003724_increased_susceptibility_to	0.97732732
59	MP0002166_altered_tumor_susceptibility	0.96483203
60	MP0001873_stomach_inflammation	0.94064994
61	MP0001727_abnormal_embryo_implantation	0.91259781
62	MP0006276_abnormal_autonomic_nervous	0.90640999
63	MP0006082_CNS_inflammation	0.90246142
64	MP0002009_preneoplasia	0.90215873
65	MP0006035_abnormal_mitochondrial_morpho	0.89340144
66	MP0004142_abnormal_muscle_tone	0.88765397
67	MP0003878_abnormal_ear_physiology	0.87851727
68	MP0005377_hearing/vestibular/ear_phenot	0.87851727
69	MP0002909_abnormal_adrenal_gland	0.81976952
70	MP0002693_abnormal_pancreas_physiology	0.81902119
71	MP0002928_abnormal_bile_duct	0.80943791
72	MP0002210_abnormal_sex_determination	0.79610914
73	MP0002006_tumorigenesis	0.76548883
74	MP0003111_abnormal_nucleus_morphology	0.75158397
75	MP0002653_abnormal_ependyma_morphology	0.74711304
76	MP0002733_abnormal_thermal_nociception	0.74666090
77	MP0005253_abnormal_eye_physiology	0.74205395
78	MP0005389_reproductive_system_phenotype	0.74007523
79	MP0002272_abnormal_nervous_system	0.72690389
80	MP0008877_abnormal_DNA_methylation	0.71912674
81	MP0001119_abnormal_female_reproductive	0.71783491
82	MP0001486_abnormal_startle_reflex	0.68669555
83	MP0003698_abnormal_male_reproductive	0.67081900
84	MP0001929_abnormal_gametogenesis	0.66718282
85	MP0005410_abnormal_fertilization	0.66089267
86	MP0004957_abnormal_blastocyst_morpholog	0.65335639
87	MP0010678_abnormal_skin_adnexa	0.64679329
88	MP0008961_abnormal_basal_metabolism	0.63068285
89	MP0008873_increased_physiological_sensi	0.61930883
90	MP0000049_abnormal_middle_ear	0.60467923
91	MP0005636_abnormal_mineral_homeostasis	0.60388365
92	MP0000653_abnormal_sex_gland	0.59596204
93	MP0003283_abnormal_digestive_organ	0.59578538
94	MP0008789_abnormal_olfactory_epithelium	0.57999353
95	MP0003938_abnormal_ear_development	0.57734495
96	MP0005395_other_phenotype	0.57410258
97	MP0003121_genomic_imprinting	0.57406344
98	MP0005319_abnormal_enzyme/_coenzyme	0.56294767
99	MP0002184_abnormal_innervation	0.56183845
100	MP0008770_decreased_survivor_rate	0.55292720

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.31612065
2	Renal cortical cysts (HP:0000803)	4.21139847
3	Pancreatic cysts (HP:0001737)	4.08705966
4	Bile duct proliferation (HP:0001408)	3.94672768
5	Abnormal biliary tract physiology (HP:0012439)	3.94672768
6	Increased hepatocellular lipid droplets (HP:0006565)	3.83531423
7	Generalized aminoaciduria (HP:0002909)	3.72992754
8	Lipid accumulation in hepatocytes (HP:0006561)	3.56964893
9	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.24364710
10	Abnormality of the renal cortex (HP:0011035)	3.23146757
11	IgG deficiency (HP:0004315)	3.21274181
12	Abnormality of B cell number (HP:0010975)	3.17836150
13	Pendular nystagmus (HP:0012043)	3.12056487
14	Type II lissencephaly (HP:0007260)	3.05931034
15	Acute necrotizing encephalopathy (HP:0006965)	3.02038427
16	True hermaphroditism (HP:0010459)	3.00307472
17	Mitochondrial inheritance (HP:0001427)	2.99526854
18	Hypothermia (HP:0002045)	2.98852013
19	Renal Fanconi syndrome (HP:0001994)	2.88894105
20	Progressive inability to walk (HP:0002505)	2.87732000
21	Increased CSF lactate (HP:0002490)	2.85264063
22	B lymphocytopenia (HP:0010976)	2.83820890
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.81747376
24	Acute encephalopathy (HP:0006846)	2.77439852
25	Supernumerary spleens (HP:0009799)	2.75961054
26	Increased serum lactate (HP:0002151)	2.73101621
27	Pancreatic fibrosis (HP:0100732)	2.65971529
28	Retinal dysplasia (HP:0007973)	2.57510382
29	Sensory axonal neuropathy (HP:0003390)	2.57269658
30	Hepatic necrosis (HP:0002605)	2.53955680
31	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.52844203
32	Hypoglycemic coma (HP:0001325)	2.52333470
33	Increased intramyocellular lipid droplets (HP:0012240)	2.49732588
34	Progressive macrocephaly (HP:0004481)	2.49546052
35	Nephronophthisis (HP:0000090)	2.46377857
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.45864496
37	Short tibia (HP:0005736)	2.45668145
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43369884
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43369884
40	Limb dystonia (HP:0002451)	2.40959809
41	Lissencephaly (HP:0001339)	2.36725043
42	Eosinophilia (HP:0001880)	2.35595725
43	Hyperglycinemia (HP:0002154)	2.28720045
44	Increased corneal curvature (HP:0100692)	2.27784039
45	Keratoconus (HP:0000563)	2.27784039
46	Broad-based gait (HP:0002136)	2.25591489
47	Cortical dysplasia (HP:0002539)	2.24964903
48	Attenuation of retinal blood vessels (HP:0007843)	2.22776674
49	Delayed CNS myelination (HP:0002188)	2.19516493
50	Cystic liver disease (HP:0006706)	2.18220497
51	Methylmalonic acidemia (HP:0002912)	2.17114892
52	Unilateral renal agenesis (HP:0000122)	2.16649690
53	Molar tooth sign on MRI (HP:0002419)	2.14672367
54	Abnormality of midbrain morphology (HP:0002418)	2.14672367
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.14310235
56	Medial flaring of the eyebrow (HP:0010747)	2.14180469
57	Abolished electroretinogram (ERG) (HP:0000550)	2.12246279
58	Cerebral edema (HP:0002181)	2.12038568
59	Microvesicular hepatic steatosis (HP:0001414)	2.11175403
60	Hepatocellular necrosis (HP:0001404)	2.09852702
61	Inability to walk (HP:0002540)	2.06857107
62	Lactic acidosis (HP:0003128)	2.04968101
63	Glycosuria (HP:0003076)	2.04269417
64	Abnormality of urine glucose concentration (HP:0011016)	2.04269417
65	Increased muscle lipid content (HP:0009058)	2.04226429
66	Abnormality of macular pigmentation (HP:0008002)	2.02914421
67	Pachygyria (HP:0001302)	2.01292104
68	Severe combined immunodeficiency (HP:0004430)	1.97465972
69	Exertional dyspnea (HP:0002875)	1.96051789
70	Abnormality of eosinophils (HP:0001879)	1.91393455
71	Large for gestational age (HP:0001520)	1.91272518
72	Anencephaly (HP:0002323)	1.90203913
73	Elevated erythrocyte sedimentation rate (HP:0003565)	1.87903840
74	Muscular hypotonia of the trunk (HP:0008936)	1.87414130
75	Meckel diverticulum (HP:0002245)	1.82451451
76	Abnormality of the ileum (HP:0001549)	1.82082206
77	Brittle hair (HP:0002299)	1.81476081
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.80437072
79	Type I transferrin isoform profile (HP:0003642)	1.77546232
80	Thyroiditis (HP:0100646)	1.77044493
81	Optic disc pallor (HP:0000543)	1.76829436
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.76467667
83	Occipital encephalocele (HP:0002085)	1.76232785
84	Abnormality of the renal medulla (HP:0100957)	1.75676111
85	Exercise intolerance (HP:0003546)	1.73472707
86	Ketosis (HP:0001946)	1.73083241
87	Metaphyseal dysplasia (HP:0100255)	1.73024328
88	Progressive microcephaly (HP:0000253)	1.67689232
89	Ketoacidosis (HP:0001993)	1.67469316
90	Methylmalonic aciduria (HP:0012120)	1.66709079
91	Neonatal respiratory distress (HP:0002643)	1.65776365
92	Zonular cataract (HP:0010920)	1.65514970
93	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.65512051
94	Fatigue (HP:0012378)	1.65375523
95	Congenital, generalized hypertrichosis (HP:0004540)	1.65249999
96	Autoimmune thrombocytopenia (HP:0001973)	1.64846264
97	Increased IgM level (HP:0003496)	1.64620025
98	Choroideremia (HP:0001139)	1.62978992
99	Hyperphosphaturia (HP:0003109)	1.62902998
100	Prominent metopic ridge (HP:0005487)	1.62334425

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.33837213
2	TLK1	3.18977492
3	ZAK	3.16657176
4	NEK1	3.04759553
5	NUAK1	2.89481467
6	MAP4K2	2.79590049
7	TSSK6	2.59982706
8	SRPK1	2.44987487
9	SIK2	2.37703415
10	EIF2AK1	2.37105109
11	BCR	2.34008136
12	TRIM28	2.32577090
13	NTRK3	2.06324145
14	NME1	2.00764615
15	CDK19	1.97518406
16	MKNK1	1.96159552
17	ADRBK2	1.96005172
18	TXK	1.94602271
19	PBK	1.82750485
20	NEK2	1.80844300
21	SCYL2	1.69368728
22	INSRR	1.66701203
23	BCKDK	1.65384525
24	CDC7	1.63149661
25	STK38L	1.59788329
26	GRK6	1.57125129
27	MAPKAPK5	1.51164253
28	WNK4	1.48984466
29	MAPK13	1.43020281
30	BUB1	1.38565427
31	VRK2	1.31119961
32	FRK	1.30489545
33	TEC	1.30020838
34	MAP2K7	1.25725043
35	VRK1	1.24315602
36	GRK1	1.23162850
37	BRD4	1.22203368
38	RPS6KA5	1.21832913
39	WNK3	1.20991377
40	CCNB1	1.15811001
41	TAF1	1.05697125
42	PASK	1.05641233
43	TAOK3	1.03928900
44	DYRK2	0.99850019
45	MAP2K6	0.99045377
46	STK24	0.98061318
47	EIF2AK3	0.97440213
48	MAP3K4	0.92217406
49	ITK	0.91575638
50	CDK3	0.89358359
51	CSNK1G3	0.88808972
52	CSNK1G1	0.87306368
53	TNK2	0.84192541
54	IKBKB	0.79653861
55	CSNK1A1L	0.78965249
56	MAP3K14	0.78894291
57	CSNK1G2	0.75322031
58	KDR	0.73946951
59	MARK1	0.73304157
60	MAPKAPK3	0.72001410
61	MAPK11	0.70783635
62	STK3	0.69898503
63	TESK2	0.67697091
64	RPS6KA4	0.67123833
65	TBK1	0.64131957
66	PLK3	0.61570094
67	STK39	0.57384090
68	FES	0.55699722
69	ATR	0.55285313
70	PHKG1	0.54772339
71	PHKG2	0.54772339
72	TNIK	0.54194790
73	CASK	0.53280646
74	CHUK	0.51969367
75	JAK3	0.51601151
76	MINK1	0.50004548
77	WEE1	0.49726794
78	EIF2AK2	0.48196486
79	MAP3K12	0.47796796
80	PLK1	0.47657291
81	AURKA	0.46685167
82	AURKB	0.45603525
83	IRAK2	0.45304368
84	CSNK2A1	0.44527500
85	PRKCQ	0.42324987
86	CSNK2A2	0.42229206
87	MST4	0.41153364
88	OXSR1	0.38341695
89	RAF1	0.38273249
90	TIE1	0.37792392
91	CSNK1A1	0.37499536
92	LCK	0.36756329
93	MAPK15	0.32828419
94	LIMK1	0.32089053
95	LYN	0.31574816
96	PTK2B	0.30823265
97	PIM1	0.30760512
98	PIK3CG	0.30247239
99	DYRK1A	0.29873421
100	IGF1R	0.28698622

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.78603462
2	Proteasome_Homo sapiens_hsa03050	3.32239911
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.17699958
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.80794633
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.58164451
6	Asthma_Homo sapiens_hsa05310	2.56732832
7	Allograft rejection_Homo sapiens_hsa05330	2.32304890
8	RNA polymerase_Homo sapiens_hsa03020	2.27608314
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26059096
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.14984209
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12975681
12	Basal transcription factors_Homo sapiens_hsa03022	2.07024610
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84912432
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.80067843
15	RNA transport_Homo sapiens_hsa03013	1.76952294
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.76636280
17	Caffeine metabolism_Homo sapiens_hsa00232	1.76075626
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73519544
19	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.68292890
20	Spliceosome_Homo sapiens_hsa03040	1.67122820
21	Phototransduction_Homo sapiens_hsa04744	1.66748876
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.63219934
23	Butanoate metabolism_Homo sapiens_hsa00650	1.60031522
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.57743949
25	Parkinsons disease_Homo sapiens_hsa05012	1.56578347
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55531705
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53169965
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53127723
29	RNA degradation_Homo sapiens_hsa03018	1.50649557
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.48872865
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43869242
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35924744
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.35805634
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.27705399
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.27398748
36	Sulfur metabolism_Homo sapiens_hsa00920	1.20695873
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.20640968
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.19187553
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.10289425
40	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09858910
41	Homologous recombination_Homo sapiens_hsa03440	1.08365875
42	Regulation of autophagy_Homo sapiens_hsa04140	1.07622870
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.04438675
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02294061
45	Purine metabolism_Homo sapiens_hsa00230	1.01390755
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00867863
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96121259
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93965486
49	Alzheimers disease_Homo sapiens_hsa05010	0.93495551
50	Huntingtons disease_Homo sapiens_hsa05016	0.93084409
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92631128
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89821712
53	Propanoate metabolism_Homo sapiens_hsa00640	0.89792555
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89372062
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89249674
56	Base excision repair_Homo sapiens_hsa03410	0.89183482
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88778855
58	DNA replication_Homo sapiens_hsa03030	0.83703217
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81191742
60	One carbon pool by folate_Homo sapiens_hsa00670	0.72291916
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71717356
62	Peroxisome_Homo sapiens_hsa04146	0.71558724
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68355313
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64542289
65	Ribosome_Homo sapiens_hsa03010	0.63045609
66	African trypanosomiasis_Homo sapiens_hsa05143	0.61628150
67	Mismatch repair_Homo sapiens_hsa03430	0.61378085
68	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61317839
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.59566030
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58569889
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56785968
72	Herpes simplex infection_Homo sapiens_hsa05168	0.54847660
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.54118364
74	Metabolic pathways_Homo sapiens_hsa01100	0.52468415
75	Shigellosis_Homo sapiens_hsa05131	0.51563969
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50879679
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.49351855
78	Salivary secretion_Homo sapiens_hsa04970	0.48773434
79	Olfactory transduction_Homo sapiens_hsa04740	0.48698346
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48688252
81	Retinol metabolism_Homo sapiens_hsa00830	0.48454366
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.45076081
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.42185720
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40385256
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.39829162
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37969230
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37677783
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.37207227
89	Taste transduction_Homo sapiens_hsa04742	0.36766383
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35856402
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.35442346
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34994899
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34802450
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34735789
95	ABC transporters_Homo sapiens_hsa02010	0.34421057
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.33635115
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32309638
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31010772
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28587325
100	Viral myocarditis_Homo sapiens_hsa05416	0.28529446

EIF4BP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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