EIF4BP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.75222893
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.75222893
3regulation of translation, ncRNA-mediated (GO:0045974)4.75222893
4negative regulation of cAMP-mediated signaling (GO:0043951)4.40808142
5regulation of hippo signaling (GO:0035330)4.33026112
6response to pheromone (GO:0019236)4.15553654
7leukotriene biosynthetic process (GO:0019370)4.07629965
8translational termination (GO:0006415)3.98802636
9viral transcription (GO:0019083)3.91686871
10positive regulation of protein kinase C signaling (GO:0090037)3.84489402
11positive regulation of CREB transcription factor activity (GO:0032793)3.73701363
12rRNA methylation (GO:0031167)3.72280283
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.70020748
14regulation of mitotic spindle checkpoint (GO:1903504)3.70020748
15cellular response to ethanol (GO:0071361)3.60742387
16negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.51215852
17positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.49572348
18alanine transport (GO:0032328)3.47400140
19phosphate ion transport (GO:0006817)3.43787567
20high-density lipoprotein particle remodeling (GO:0034375)3.43539830
21regulation of heterotypic cell-cell adhesion (GO:0034114)3.39399935
22ribosomal small subunit assembly (GO:0000028)3.37028584
23phospholipid efflux (GO:0033700)3.29574636
24histone H2A acetylation (GO:0043968)3.25173425
25negative regulation of protein localization to cell surface (GO:2000009)3.22878556
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21946262
27detection of light stimulus involved in sensory perception (GO:0050962)3.20319321
28detection of light stimulus involved in visual perception (GO:0050908)3.20319321
29regulation of cholesterol esterification (GO:0010872)3.17391242
30cellular ketone body metabolic process (GO:0046950)3.16445438
31aminoglycoside antibiotic metabolic process (GO:0030647)3.15292325
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14126317
33head development (GO:0060322)3.11107371
34leukotriene metabolic process (GO:0006691)3.09768798
35sensory perception of taste (GO:0050909)3.08880989
36cotranslational protein targeting to membrane (GO:0006613)3.06413023
37ribosomal small subunit biogenesis (GO:0042274)3.06185300
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04661989
39protein targeting to ER (GO:0045047)3.02711100
40cellular protein complex disassembly (GO:0043624)3.02554309
41dentate gyrus development (GO:0021542)3.01371911
42translational elongation (GO:0006414)3.00603638
43cellular response to zinc ion (GO:0071294)2.98633226
44positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.97143304
45negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96834469
46establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93940899
47rRNA modification (GO:0000154)2.93547124
48negative regulation of interleukin-1 beta production (GO:0032691)2.93333745
49urate metabolic process (GO:0046415)2.92406531
50valine metabolic process (GO:0006573)2.91724787
51regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.91472621
52positive regulation of Rho protein signal transduction (GO:0035025)2.89958193
53multicellular organism reproduction (GO:0032504)2.88268373
54negative regulation of heart rate (GO:0010459)2.85482724
55phospholipid homeostasis (GO:0055091)2.84497338
56protein localization to cilium (GO:0061512)2.83851601
57protein localization to endoplasmic reticulum (GO:0070972)2.82968672
58pyrimidine dimer repair (GO:0006290)2.82156367
59activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.80102456
60neural tube formation (GO:0001841)2.77159982
61protein K48-linked deubiquitination (GO:0071108)2.75954005
62ketone body metabolic process (GO:1902224)2.74462067
63pyrimidine nucleobase catabolic process (GO:0006208)2.72663333
64reverse cholesterol transport (GO:0043691)2.72066081
65motile cilium assembly (GO:0044458)2.68959822
66positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68336711
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68323727
68positive regulation of granulocyte differentiation (GO:0030854)2.68217075
69cAMP catabolic process (GO:0006198)2.64655463
70glutathione metabolic process (GO:0006749)2.64638170
71reciprocal meiotic recombination (GO:0007131)2.64293400
72reciprocal DNA recombination (GO:0035825)2.64293400
73sperm motility (GO:0030317)2.64040939
74positive regulation of action potential (GO:0045760)2.62591848
75positive regulation of uterine smooth muscle contraction (GO:0070474)2.62464816
76regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62338137
77establishment of protein localization to Golgi (GO:0072600)2.62236711
78quinone biosynthetic process (GO:1901663)2.60258012
79indolalkylamine metabolic process (GO:0006586)2.58126671
80epithelial cilium movement (GO:0003351)2.55936066
81positive regulation of developmental pigmentation (GO:0048087)2.53523912
82photoreceptor cell maintenance (GO:0045494)2.53288997
83estrogen biosynthetic process (GO:0006703)2.52606479
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.52224746
85regulation of pigment cell differentiation (GO:0050932)2.51276650
86tyrosine phosphorylation of STAT protein (GO:0007260)2.49761044
87indole-containing compound metabolic process (GO:0042430)2.48869328
88maturation of SSU-rRNA (GO:0030490)2.48724884
89viral life cycle (GO:0019058)2.48260052
90lipopolysaccharide biosynthetic process (GO:0009103)2.47675611
91translational initiation (GO:0006413)2.47663424
92negative regulation of lipid catabolic process (GO:0050995)2.47584108
93nephron epithelium morphogenesis (GO:0072088)2.46278838
94nephron tubule morphogenesis (GO:0072078)2.46278838
95centriole replication (GO:0007099)2.46266875
96prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.46126638
97protein complex disassembly (GO:0043241)2.45082224
98skeletal muscle tissue regeneration (GO:0043403)2.43806220
99lymph vessel development (GO:0001945)2.43479051
100phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.41675756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.77503345
2GBX2_23144817_ChIP-Seq_PC3_Human3.30612442
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11511980
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10733025
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07790075
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.01064243
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97522865
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.77288253
9ZNF274_21170338_ChIP-Seq_K562_Hela2.35929821
10FUS_26573619_Chip-Seq_HEK293_Human2.27959343
11TAF15_26573619_Chip-Seq_HEK293_Human2.26952605
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.23290470
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16675589
14VDR_22108803_ChIP-Seq_LS180_Human2.10210711
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00965622
16EZH2_22144423_ChIP-Seq_EOC_Human2.00606758
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89761111
18ER_23166858_ChIP-Seq_MCF-7_Human1.88363322
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88097739
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.86607426
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.85170258
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80003547
23P300_19829295_ChIP-Seq_ESCs_Human1.79185210
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79103098
25ELK1_19687146_ChIP-ChIP_HELA_Human1.78483271
26CBP_20019798_ChIP-Seq_JUKART_Human1.73634629
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73634629
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.66637400
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66268961
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65088602
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60561038
32SMAD4_21799915_ChIP-Seq_A2780_Human1.59253192
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.58078620
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57532656
35STAT3_23295773_ChIP-Seq_U87_Human1.56286594
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54560869
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53967967
38EWS_26573619_Chip-Seq_HEK293_Human1.53919360
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50434521
40RXR_22108803_ChIP-Seq_LS180_Human1.49723290
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48124844
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45896066
43IGF1R_20145208_ChIP-Seq_DFB_Human1.43887855
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42552160
45IRF1_19129219_ChIP-ChIP_H3396_Human1.41102204
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40337982
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.39853037
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39270539
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37903549
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.36144453
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.36096520
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34543152
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34108675
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33538287
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31878905
56AR_21572438_ChIP-Seq_LNCaP_Human1.31612697
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31283583
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.29741631
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29345458
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26849435
61SOX2_19829295_ChIP-Seq_ESCs_Human1.26748852
62NANOG_19829295_ChIP-Seq_ESCs_Human1.26748852
63AR_25329375_ChIP-Seq_VCAP_Human1.25944363
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24866001
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.23664455
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.23328701
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.22714615
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21996434
69TCF4_23295773_ChIP-Seq_U87_Human1.20707497
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.20076548
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19108142
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18733175
73TP53_18474530_ChIP-ChIP_U2OS_Human1.17588794
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17207636
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17207636
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16255845
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16237378
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15675372
79TCF4_22108803_ChIP-Seq_LS180_Human1.14985118
80BCAT_22108803_ChIP-Seq_LS180_Human1.14763620
81P53_22387025_ChIP-Seq_ESCs_Mouse1.10186747
82RUNX2_22187159_ChIP-Seq_PCA_Human1.09724384
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.08166482
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.07861550
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.06412186
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04573709
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.02896811
88CDX2_22108803_ChIP-Seq_LS180_Human1.01827818
89P300_18555785_Chip-Seq_ESCs_Mouse1.01113523
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.01112297
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.98799995
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98790961
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98222540
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98074227
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98053517
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97388571
97SCL_19346495_ChIP-Seq_HPC-7_Human0.97173777
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95449727
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95359317
100RNF2_27304074_Chip-Seq_NSC_Mouse0.94174583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.45905658
2MP0008995_early_reproductive_senescence3.10418816
3MP0002163_abnormal_gland_morphology2.67272694
4MP0006072_abnormal_retinal_apoptosis2.56226531
5MP0005377_hearing/vestibular/ear_phenot2.53086506
6MP0003878_abnormal_ear_physiology2.53086506
7MP0005379_endocrine/exocrine_gland_phen2.41324784
8MP0003880_abnormal_central_pattern2.39399976
9MP0006292_abnormal_olfactory_placode2.36865920
10MP0009840_abnormal_foam_cell2.35925091
11MP0002009_preneoplasia2.35281817
12MP0001986_abnormal_taste_sensitivity2.32566474
13MP0004142_abnormal_muscle_tone2.27766836
14MP0003136_yellow_coat_color2.05583057
15MP0008877_abnormal_DNA_methylation2.04292172
16MP0005397_hematopoietic_system_phenotyp1.87254296
17MP0001545_abnormal_hematopoietic_system1.87254296
18MP0000427_abnormal_hair_cycle1.87110122
19MP0005551_abnormal_eye_electrophysiolog1.84146649
20MP0000516_abnormal_urinary_system1.83407609
21MP0005367_renal/urinary_system_phenotyp1.83407609
22MP0008058_abnormal_DNA_repair1.77939161
23MP0008872_abnormal_physiological_respon1.77102016
24MP0005253_abnormal_eye_physiology1.74709171
25MP0000230_abnormal_systemic_arterial1.71406701
26MP0004215_abnormal_myocardial_fiber1.68723615
27MP0003191_abnormal_cellular_cholesterol1.65231374
28MP0010386_abnormal_urinary_bladder1.63357711
29MP0005410_abnormal_fertilization1.62233644
30MP0003195_calcinosis1.61957395
31MP0010329_abnormal_lipoprotein_level1.58582398
32MP0001879_abnormal_lymphatic_vessel1.58501727
33MP0006276_abnormal_autonomic_nervous1.54850155
34MP0005646_abnormal_pituitary_gland1.50761658
35MP0005085_abnormal_gallbladder_physiolo1.48275772
36MP0005503_abnormal_tendon_morphology1.46627110
37MP0005645_abnormal_hypothalamus_physiol1.44125938
38MP0004147_increased_porphyrin_level1.41245898
39MP0008775_abnormal_heart_ventricle1.39022075
40MP0002332_abnormal_exercise_endurance1.35120407
41MP0003718_maternal_effect1.35062925
42MP0002733_abnormal_thermal_nociception1.26462540
43MP0004085_abnormal_heartbeat1.25795510
44MP0002102_abnormal_ear_morphology1.25475632
45MP0004883_abnormal_blood_vessel1.18104788
46MP0008875_abnormal_xenobiotic_pharmacok1.16009199
47MP0001764_abnormal_homeostasis1.15383182
48MP0000631_abnormal_neuroendocrine_gland1.15304735
49MP0004808_abnormal_hematopoietic_stem1.15301273
50MP0001486_abnormal_startle_reflex1.12386580
51MP0001756_abnormal_urination1.12249514
52MP0003698_abnormal_male_reproductive1.10949989
53MP0003252_abnormal_bile_duct1.04776540
54MP0004019_abnormal_vitamin_homeostasis1.03165452
55MP0004484_altered_response_of1.02643584
56MP0003763_abnormal_thymus_physiology1.02045893
57MP0009697_abnormal_copulation1.01727079
58MP0003656_abnormal_erythrocyte_physiolo1.01505644
59MP0003786_premature_aging0.99443279
60MP0003045_fibrosis0.99259582
61MP0009046_muscle_twitch0.98552914
62MP0001929_abnormal_gametogenesis0.97336123
63MP0004043_abnormal_pH_regulation0.97020206
64MP0002067_abnormal_sensory_capabilities0.96817405
65MP0005448_abnormal_energy_balance0.96377279
66MP0001970_abnormal_pain_threshold0.96120900
67MP0009765_abnormal_xenobiotic_induced0.95332701
68MP0002272_abnormal_nervous_system0.94886744
69MP0005164_abnormal_response_to0.93242166
70MP0009379_abnormal_foot_pigmentation0.93101943
71MP0002166_altered_tumor_susceptibility0.91483800
72MP0005376_homeostasis/metabolism_phenot0.91135930
73MP0002006_tumorigenesis0.89925792
74MP0003890_abnormal_embryonic-extraembry0.86733813
75MP0010352_gastrointestinal_tract_polyps0.85399066
76MP0001790_abnormal_immune_system0.85268385
77MP0005387_immune_system_phenotype0.85268385
78MP0004510_myositis0.83862416
79MP0001873_stomach_inflammation0.83163241
80MP0002184_abnormal_innervation0.81346698
81MP0002095_abnormal_skin_pigmentation0.78649230
82MP0006035_abnormal_mitochondrial_morpho0.78578918
83MP0001968_abnormal_touch/_nociception0.77314617
84MP0002160_abnormal_reproductive_system0.77173431
85MP0000639_abnormal_adrenal_gland0.76983606
86MP0001119_abnormal_female_reproductive0.74991087
87MP0005395_other_phenotype0.74158465
88MP0000569_abnormal_digit_pigmentation0.74090452
89MP0003724_increased_susceptibility_to0.73492805
90MP0005464_abnormal_platelet_physiology0.73245229
91MP0003119_abnormal_digestive_system0.72579177
92MP0000372_irregular_coat_pigmentation0.72089756
93MP0002210_abnormal_sex_determination0.71995389
94MP0005310_abnormal_salivary_gland0.71761668
95MP0009745_abnormal_behavioral_response0.70936270
96MP0001800_abnormal_humoral_immune0.70845150
97MP0005332_abnormal_amino_acid0.70403110
98MP0004145_abnormal_muscle_electrophysio0.70369498
99MP0002752_abnormal_somatic_nervous0.70311443
100MP0000163_abnormal_cartilage_morphology0.70248194

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.75979673
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.48602339
3Spontaneous abortion (HP:0005268)4.41306261
4Pancreatic cysts (HP:0001737)4.15021084
5Abnormal rod and cone electroretinograms (HP:0008323)4.06868303
6Congenital stationary night blindness (HP:0007642)4.04905652
7Pancreatic fibrosis (HP:0100732)3.91200642
8Attenuation of retinal blood vessels (HP:0007843)3.58281861
9True hermaphroditism (HP:0010459)3.54927898
10Pendular nystagmus (HP:0012043)3.52027746
11Carpal bone hypoplasia (HP:0001498)3.47261937
12Severe visual impairment (HP:0001141)3.40085827
13Renal cortical cysts (HP:0000803)3.14308150
14Colon cancer (HP:0003003)3.13976888
15Constricted visual fields (HP:0001133)3.07297823
16Proximal tubulopathy (HP:0000114)2.93572095
17Gaze-evoked nystagmus (HP:0000640)2.91899507
18Genetic anticipation (HP:0003743)2.90935566
19Hyperventilation (HP:0002883)2.89357884
20Broad ribs (HP:0000885)2.84222590
21Abnormality of midbrain morphology (HP:0002418)2.74256121
22Molar tooth sign on MRI (HP:0002419)2.74256121
23Aplasia/Hypoplasia of the tibia (HP:0005772)2.73304837
24Abolished electroretinogram (ERG) (HP:0000550)2.64400220
25Gingival bleeding (HP:0000225)2.62251869
26Aplasia/Hypoplasia involving the musculature (HP:0001460)2.61818967
27Reticulocytopenia (HP:0001896)2.59099902
28Hypoplasia of the fovea (HP:0007750)2.57836272
29Aplasia/Hypoplasia of the fovea (HP:0008060)2.57836272
30Facial diplegia (HP:0001349)2.54181526
31Glycosuria (HP:0003076)2.48691341
32Abnormality of urine glucose concentration (HP:0011016)2.48691341
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.44893345
34Bony spicule pigmentary retinopathy (HP:0007737)2.42836346
35Chronic hepatic failure (HP:0100626)2.41921040
36Abnormal number of erythroid precursors (HP:0012131)2.41855161
37Abnormality of the renal cortex (HP:0011035)2.36377462
38Abnormality of cells of the erythroid lineage (HP:0012130)2.35363673
39Cystic liver disease (HP:0006706)2.33438832
40Renal Fanconi syndrome (HP:0001994)2.27499640
41Absent/shortened dynein arms (HP:0200106)2.26745739
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.26745739
43Anencephaly (HP:0002323)2.24840400
44Lissencephaly (HP:0001339)2.20231107
45Abnormality of the labia minora (HP:0012880)2.18822250
46Progressive cerebellar ataxia (HP:0002073)2.16576072
47Lipid accumulation in hepatocytes (HP:0006561)2.15849185
48Chorioretinal atrophy (HP:0000533)2.13899437
49Thyroiditis (HP:0100646)2.13077298
50Nausea (HP:0002018)2.13009998
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.11476605
52Abnormality of methionine metabolism (HP:0010901)2.10242299
53Type II lissencephaly (HP:0007260)2.09734467
54Abnormality of DNA repair (HP:0003254)2.09582965
55Sloping forehead (HP:0000340)2.07588539
56Decreased central vision (HP:0007663)2.07330410
57Nephronophthisis (HP:0000090)2.04577606
58Recurrent bronchitis (HP:0002837)2.04511817
59Increased hepatocellular lipid droplets (HP:0006565)2.04209714
60Beaking of vertebral bodies (HP:0004568)2.04069574
61Amyloidosis (HP:0011034)2.03307492
62Short hallux (HP:0010109)2.02997729
63Postaxial foot polydactyly (HP:0001830)2.01771066
64Hepatoblastoma (HP:0002884)1.99280643
65Pachygyria (HP:0001302)1.96448565
66Short tibia (HP:0005736)1.96084068
67Increased corneal curvature (HP:0100692)1.95398855
68Keratoconus (HP:0000563)1.95398855
69Medial flaring of the eyebrow (HP:0010747)1.93528693
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93004753
71Abnormality of the fovea (HP:0000493)1.91443115
72Palpebral edema (HP:0100540)1.88577387
73Diastasis recti (HP:0001540)1.88337022
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87175089
75Inability to walk (HP:0002540)1.87020929
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84914459
77Progressive inability to walk (HP:0002505)1.82786147
78Abnormality of the renal medulla (HP:0100957)1.82386814
79Rib fusion (HP:0000902)1.81435166
80Dyskinesia (HP:0100660)1.81068707
81Absent speech (HP:0001344)1.80884656
82Dyschromatopsia (HP:0007641)1.79343259
83Hypoplasia of the thymus (HP:0000778)1.79018907
84Widely spaced teeth (HP:0000687)1.78799879
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78681995
86Aplasia of the musculature (HP:0100854)1.77814737
87Sclerocornea (HP:0000647)1.75830422
88Tubulointerstitial nephritis (HP:0001970)1.75685080
89Abnormality of the astrocytes (HP:0100707)1.75380479
90Astrocytoma (HP:0009592)1.75380479
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75027116
92Optic nerve hypoplasia (HP:0000609)1.70013941
93Abnormality of alanine metabolism (HP:0010916)1.69343889
94Hyperalaninemia (HP:0003348)1.69343889
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69343889
96Macular degeneration (HP:0000608)1.68847389
97Rhabdomyosarcoma (HP:0002859)1.64755195
98Congenital hepatic fibrosis (HP:0002612)1.64590508
99Pulmonary artery stenosis (HP:0004415)1.63253594
100Scotoma (HP:0000575)1.62602783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.60874707
2STK163.01139151
3CAMKK22.97255661
4TLK12.96502943
5SRPK12.41768223
6BRSK22.37044952
7TXK2.35951028
8NUAK12.03475451
9ZAK2.00907177
10MAP4K21.98529332
11NLK1.90337281
12WNK31.88565902
13PLK41.81810499
14CDK191.74662751
15MKNK11.67467565
16INSRR1.64488334
17BMPR1B1.57893517
18PDK21.51154859
19AKT31.47046870
20TAOK31.43232097
21CASK1.37253161
22ACVR1B1.30518478
23EPHA41.29295233
24WNK41.25158957
25MAP3K41.20985691
26ADRBK21.18231938
27ADRBK11.15258015
28VRK11.11127745
29CSNK1G11.09675476
30TNIK1.07439096
31EPHB21.02861144
32PBK0.98140086
33CDK30.98051609
34PIK3CG0.95741796
35MAPK130.95212889
36PRKCQ0.94898051
37SYK0.91749431
38MYLK0.87712699
39SGK20.87345195
40PTK2B0.87164344
41TEC0.87053004
42OXSR10.85938567
43TNK20.84190602
44CAMK40.81585993
45CAMK10.80661572
46CSNK1A1L0.78623208
47OBSCN0.77689571
48TGFBR10.76817311
49MAPKAPK50.76547955
50CDK80.75810652
51CAMK1D0.74900732
52EPHA30.73840683
53CSNK1G30.73737841
54PAK30.71953975
55CSNK1G20.71776220
56PIK3CA0.70669878
57STK390.68473309
58GRK10.67351688
59TSSK60.64592360
60KIT0.63372300
61PKN10.63038639
62CCNB10.59399208
63BTK0.58972406
64BRSK10.55142712
65PRKCE0.54441934
66PRKG10.53686219
67SGK2230.53410265
68SGK4940.53410265
69MELK0.53193396
70MKNK20.51984288
71MST40.51735340
72CSNK1A10.51372031
73CHEK20.50744732
74NTRK30.49862096
75RPS6KA50.49370027
76IRAK10.48769520
77MAP4K10.48715219
78SGK10.48039525
79STK110.47079893
80PDGFRB0.45834541
81MAP2K60.45755150
82IKBKE0.45547961
83MAP3K20.44949686
84DDR20.44800769
85TRIM280.43229819
86CSNK1E0.42425637
87PLK30.41485680
88PRKCG0.41089563
89DYRK20.40791914
90PRKACA0.39664845
91PIM10.39349370
92CSNK1D0.39193773
93STK38L0.39148787
94GRK70.38380415
95BLK0.38271008
96IKBKB0.38213988
97LYN0.37583870
98TIE10.37291022
99SGK30.35346331
100WNK10.34603554

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.44093652
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.80183261
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50148921
4Vitamin digestion and absorption_Homo sapiens_hsa049772.28254817
5Taste transduction_Homo sapiens_hsa047422.19393340
6Linoleic acid metabolism_Homo sapiens_hsa005912.10406690
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03388160
8Steroid hormone biosynthesis_Homo sapiens_hsa001401.95632991
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91802887
10Renin-angiotensin system_Homo sapiens_hsa046141.84945627
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81201739
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.75178624
13Fanconi anemia pathway_Homo sapiens_hsa034601.70287445
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67148747
15Butanoate metabolism_Homo sapiens_hsa006501.61896671
16Nicotine addiction_Homo sapiens_hsa050331.61392363
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57469910
18Phototransduction_Homo sapiens_hsa047441.56733317
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56512147
20Homologous recombination_Homo sapiens_hsa034401.56171725
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53789713
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.49700890
23Oxidative phosphorylation_Homo sapiens_hsa001901.48337314
24Parkinsons disease_Homo sapiens_hsa050121.43403854
25Chemical carcinogenesis_Homo sapiens_hsa052041.40256526
26Ovarian steroidogenesis_Homo sapiens_hsa049131.32803703
27Circadian rhythm_Homo sapiens_hsa047101.32711326
28Retinol metabolism_Homo sapiens_hsa008301.30344991
29Renin secretion_Homo sapiens_hsa049241.29051643
30Platelet activation_Homo sapiens_hsa046111.25113939
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24627468
32Arachidonic acid metabolism_Homo sapiens_hsa005901.24422399
33Mineral absorption_Homo sapiens_hsa049781.22828303
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19443812
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.17915856
36Peroxisome_Homo sapiens_hsa041461.14531065
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11186444
38Olfactory transduction_Homo sapiens_hsa047401.09564848
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08939958
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.08072506
41Non-homologous end-joining_Homo sapiens_hsa034501.06132586
42Nitrogen metabolism_Homo sapiens_hsa009101.05489541
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01948046
44African trypanosomiasis_Homo sapiens_hsa051431.01735208
45Asthma_Homo sapiens_hsa053101.00411978
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00095120
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00032908
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98965994
49Fat digestion and absorption_Homo sapiens_hsa049750.98884232
50Basal transcription factors_Homo sapiens_hsa030220.98100430
51Alzheimers disease_Homo sapiens_hsa050100.97316918
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94247307
53Oxytocin signaling pathway_Homo sapiens_hsa049210.91852194
54RNA polymerase_Homo sapiens_hsa030200.91261511
55Morphine addiction_Homo sapiens_hsa050320.91176781
56Selenocompound metabolism_Homo sapiens_hsa004500.89114202
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88333702
58Calcium signaling pathway_Homo sapiens_hsa040200.87573741
59Glutathione metabolism_Homo sapiens_hsa004800.87187111
60Huntingtons disease_Homo sapiens_hsa050160.86049068
61Autoimmune thyroid disease_Homo sapiens_hsa053200.85610645
62Tryptophan metabolism_Homo sapiens_hsa003800.84220129
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82444097
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81836497
65Salivary secretion_Homo sapiens_hsa049700.81455582
66Glycerolipid metabolism_Homo sapiens_hsa005610.80626722
67T cell receptor signaling pathway_Homo sapiens_hsa046600.80563012
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79918755
69Systemic lupus erythematosus_Homo sapiens_hsa053220.79557481
70Ether lipid metabolism_Homo sapiens_hsa005650.79003018
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76864556
72Steroid biosynthesis_Homo sapiens_hsa001000.74567241
73Allograft rejection_Homo sapiens_hsa053300.74562842
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73815374
75Graft-versus-host disease_Homo sapiens_hsa053320.70465675
76Long-term depression_Homo sapiens_hsa047300.69978164
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69810064
78ABC transporters_Homo sapiens_hsa020100.67834089
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.67472955
80Propanoate metabolism_Homo sapiens_hsa006400.65462634
81Cocaine addiction_Homo sapiens_hsa050300.62777288
82Cardiac muscle contraction_Homo sapiens_hsa042600.62637379
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62222819
84Glutamatergic synapse_Homo sapiens_hsa047240.60123627
85Caffeine metabolism_Homo sapiens_hsa002320.59456905
86GABAergic synapse_Homo sapiens_hsa047270.57827781
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57521561
88RNA transport_Homo sapiens_hsa030130.57316360
89Alcoholism_Homo sapiens_hsa050340.56467617
90Amphetamine addiction_Homo sapiens_hsa050310.55184999
91PPAR signaling pathway_Homo sapiens_hsa033200.53313342
92cAMP signaling pathway_Homo sapiens_hsa040240.50619728
93Collecting duct acid secretion_Homo sapiens_hsa049660.50268723
94Hematopoietic cell lineage_Homo sapiens_hsa046400.50142540
95Purine metabolism_Homo sapiens_hsa002300.48992685
96Nucleotide excision repair_Homo sapiens_hsa034200.44639662
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44422668
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43249917
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42908182
100FoxO signaling pathway_Homo sapiens_hsa040680.40832123

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