EIF4BP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)5.53065368
2positive regulation of interleukin-17 production (GO:0032740)5.38227263
3ubiquinone metabolic process (GO:0006743)4.98012901
4viral mRNA export from host cell nucleus (GO:0046784)4.61304615
5water-soluble vitamin biosynthetic process (GO:0042364)4.15559833
6pseudouridine synthesis (GO:0001522)4.01311514
7ubiquinone biosynthetic process (GO:0006744)3.84280315
8ribosome assembly (GO:0042255)3.72746238
9regulation of isotype switching to IgG isotypes (GO:0048302)3.70865202
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70583994
11negative regulation of acute inflammatory response (GO:0002674)3.69504219
12positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.69190809
13chaperone-mediated protein transport (GO:0072321)3.69028387
14regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.63207064
15regulation of chronic inflammatory response (GO:0002676)3.49543537
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.48945822
17regulation of natural killer cell differentiation (GO:0032823)3.47294728
18adenosine metabolic process (GO:0046085)3.46264511
19positive regulation of natural killer cell mediated immunity (GO:0002717)3.44163909
20proteasome assembly (GO:0043248)3.32312265
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31244953
22ATP synthesis coupled proton transport (GO:0015986)3.31244953
23regulation of double-strand break repair via homologous recombination (GO:0010569)3.25689889
24CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.23600473
25CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.17308822
26T-helper cell differentiation (GO:0042093)3.17308822
27adaptation of signaling pathway (GO:0023058)3.14392950
28positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.14119450
29protein neddylation (GO:0045116)3.13655528
30dopamine transport (GO:0015872)3.12455025
31cellular response to interleukin-15 (GO:0071350)3.12269416
32regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.10948071
33maternal behavior (GO:0042711)3.07852422
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07848079
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07848079
36quinone biosynthetic process (GO:1901663)3.04453932
37DNA double-strand break processing (GO:0000729)3.04183842
38single strand break repair (GO:0000012)3.03644425
39mitochondrial RNA metabolic process (GO:0000959)2.99286316
40kidney morphogenesis (GO:0060993)2.97492345
41peptidyl-arginine methylation (GO:0018216)2.97311751
42peptidyl-arginine N-methylation (GO:0035246)2.97311751
43behavioral response to nicotine (GO:0035095)2.93749472
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.92388164
45negative regulation of T cell differentiation in thymus (GO:0033085)2.92250321
46replication fork processing (GO:0031297)2.89074125
47vitamin biosynthetic process (GO:0009110)2.88604242
48mechanosensory behavior (GO:0007638)2.88568708
49negative regulation of T-helper cell differentiation (GO:0045623)2.86919860
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86919860
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.86546754
52termination of RNA polymerase III transcription (GO:0006386)2.86546754
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86366155
54regulation of translational termination (GO:0006449)2.85581404
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85107579
56mitochondrial respiratory chain complex I assembly (GO:0032981)2.85107579
57NADH dehydrogenase complex assembly (GO:0010257)2.85107579
58positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82577401
59protein K11-linked deubiquitination (GO:0035871)2.81726679
60meiotic chromosome segregation (GO:0045132)2.79993219
61T cell differentiation involved in immune response (GO:0002292)2.79188211
62alpha-beta T cell differentiation involved in immune response (GO:0002293)2.79188211
63alpha-beta T cell activation involved in immune response (GO:0002287)2.79188211
64protein complex biogenesis (GO:0070271)2.78428079
65histone H2A acetylation (GO:0043968)2.76632639
66parental behavior (GO:0060746)2.74429944
67anterograde synaptic vesicle transport (GO:0048490)2.73793216
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.71839495
69substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70682793
70substrate-independent telencephalic tangential migration (GO:0021826)2.70682793
71peristalsis (GO:0030432)2.67715786
72mitochondrial respiratory chain complex assembly (GO:0033108)2.67292287
73RNA destabilization (GO:0050779)2.66354829
74positive regulation of interleukin-10 production (GO:0032733)2.65578214
75negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63580220
76positive regulation of mRNA 3-end processing (GO:0031442)2.63005729
77tRNA processing (GO:0008033)2.62677674
78prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.62011533
79positive regulation of mRNA processing (GO:0050685)2.59699948
80male meiosis I (GO:0007141)2.59603044
81positive regulation of cell fate commitment (GO:0010455)2.59524669
82DNA deamination (GO:0045006)2.58854117
83auditory receptor cell stereocilium organization (GO:0060088)2.58477756
84DNA replication-dependent nucleosome assembly (GO:0006335)2.56015699
85DNA replication-dependent nucleosome organization (GO:0034723)2.56015699
86peptidyl-arginine omega-N-methylation (GO:0035247)2.55754379
87spliceosomal snRNP assembly (GO:0000387)2.55357809
88cytokine biosynthetic process (GO:0042089)2.55027308
89double-strand break repair via homologous recombination (GO:0000724)2.54866030
90recombinational repair (GO:0000725)2.53558051
91regulation of centriole replication (GO:0046599)2.53205036
92spinal cord association neuron differentiation (GO:0021527)2.51417536
93inner mitochondrial membrane organization (GO:0007007)2.50009216
94fucose catabolic process (GO:0019317)2.48925199
95L-fucose metabolic process (GO:0042354)2.48925199
96L-fucose catabolic process (GO:0042355)2.48925199
97spliceosomal complex assembly (GO:0000245)2.48767731
98positive regulation of natural killer cell activation (GO:0032816)2.48171180
99prostate gland growth (GO:0060736)2.47469034
100regulation of natural killer cell mediated immunity (GO:0002715)2.46052782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.97049024
2VDR_22108803_ChIP-Seq_LS180_Human4.57735972
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.22731807
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28826965
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.05692203
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.04905956
7TAF15_26573619_Chip-Seq_HEK293_Human2.73743591
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56141285
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54667492
10IGF1R_20145208_ChIP-Seq_DFB_Human2.48950966
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44241646
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.39638530
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33893934
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23761222
15ZNF274_21170338_ChIP-Seq_K562_Hela2.17209340
16EWS_26573619_Chip-Seq_HEK293_Human2.13417358
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12629128
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11434612
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02271805
20VDR_23849224_ChIP-Seq_CD4+_Human1.98265573
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.93288949
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92275084
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81205304
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80214464
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.79619170
26FUS_26573619_Chip-Seq_HEK293_Human1.77129998
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.75946157
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75007558
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73724295
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71326789
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65411098
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61538248
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59812696
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58075045
35GBX2_23144817_ChIP-Seq_PC3_Human1.55623401
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55489022
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54941551
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50669204
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.48813966
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48754613
41FOXP3_21729870_ChIP-Seq_TREG_Human1.48181065
42MYC_18940864_ChIP-ChIP_HL60_Human1.47275943
43P300_19829295_ChIP-Seq_ESCs_Human1.45902405
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45885952
45TP53_22573176_ChIP-Seq_HFKS_Human1.45674002
46CBP_20019798_ChIP-Seq_JUKART_Human1.43144779
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43144779
48ER_23166858_ChIP-Seq_MCF-7_Human1.42895428
49GATA1_22025678_ChIP-Seq_K562_Human1.41781878
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39292170
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37827662
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34736984
53BCAT_22108803_ChIP-Seq_LS180_Human1.27112755
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.26884891
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.22901865
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21900003
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21611165
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20670133
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18620079
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17461961
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.17263106
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16506213
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15226404
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.12870226
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10264279
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10264279
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09583112
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08696077
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.08263160
70TCF4_22108803_ChIP-Seq_LS180_Human1.07541832
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07350997
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05283886
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03720428
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02194796
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01101907
76SOX9_26525672_Chip-Seq_HEART_Mouse1.00466587
77RXR_22108803_ChIP-Seq_LS180_Human0.98255318
78CIITA_25753668_ChIP-Seq_RAJI_Human0.98210627
79TTF2_22483619_ChIP-Seq_HELA_Human0.97478902
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97430757
81EZH2_22144423_ChIP-Seq_EOC_Human0.95737148
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95411628
83MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94663220
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93918252
85HOXB7_26014856_ChIP-Seq_BT474_Human0.93469016
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91712961
87MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90621621
88TCF4_23295773_ChIP-Seq_U87_Human0.90014989
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88058668
90STAT3_23295773_ChIP-Seq_U87_Human0.87092975
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86790317
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.86638383
93NCOR_22424771_ChIP-Seq_293T_Human0.85786548
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84767432
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82969925
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82268455
97KDM5A_27292631_Chip-Seq_BREAST_Human0.81419466
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81283679
99PHF8_20622853_ChIP-Seq_HELA_Human0.81229904
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81116666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.53650990
2MP0002102_abnormal_ear_morphology2.69111040
3MP0008058_abnormal_DNA_repair2.68740300
4MP0003646_muscle_fatigue2.65835459
5MP0000537_abnormal_urethra_morphology2.58605075
6MP0002822_catalepsy2.46124787
7MP0001188_hyperpigmentation2.45510600
8MP0000566_synostosis2.44603392
9MP0005084_abnormal_gallbladder_morpholo2.42322379
10MP0000569_abnormal_digit_pigmentation2.37270771
11MP0000372_irregular_coat_pigmentation2.31191392
12MP0002138_abnormal_hepatobiliary_system2.28598877
13MP0001873_stomach_inflammation2.28204685
14MP0008872_abnormal_physiological_respon2.21378116
15MP0004742_abnormal_vestibular_system2.18337938
16MP0004145_abnormal_muscle_electrophysio2.08984137
17MP0000631_abnormal_neuroendocrine_gland2.08669773
18MP0003938_abnormal_ear_development1.90779294
19MP0009379_abnormal_foot_pigmentation1.87726276
20MP0001968_abnormal_touch/_nociception1.85414280
21MP0005646_abnormal_pituitary_gland1.83979024
22MP0006292_abnormal_olfactory_placode1.77221965
23MP0003950_abnormal_plasma_membrane1.76145703
24MP0006072_abnormal_retinal_apoptosis1.68769540
25MP0005671_abnormal_response_to1.61008705
26MP0002736_abnormal_nociception_after1.59842785
27MP0008877_abnormal_DNA_methylation1.59436304
28MP0005645_abnormal_hypothalamus_physiol1.59051070
29MP0002938_white_spotting1.57835809
30MP0001986_abnormal_taste_sensitivity1.53693597
31MP0008789_abnormal_olfactory_epithelium1.52678740
32MP0000383_abnormal_hair_follicle1.51506654
33MP0000049_abnormal_middle_ear1.46390914
34MP0002163_abnormal_gland_morphology1.43493899
35MP0003937_abnormal_limbs/digits/tail_de1.41094008
36MP0003045_fibrosis1.38691788
37MP0004957_abnormal_blastocyst_morpholog1.32841686
38MP0003786_premature_aging1.32765602
39MP0009745_abnormal_behavioral_response1.31782926
40MP0005174_abnormal_tail_pigmentation1.30833481
41MP0005551_abnormal_eye_electrophysiolog1.29944487
42MP0002735_abnormal_chemical_nociception1.26528621
43MP0001984_abnormal_olfaction1.26138613
44MP0008875_abnormal_xenobiotic_pharmacok1.24793266
45MP0003718_maternal_effect1.23777139
46MP0008961_abnormal_basal_metabolism1.20863988
47MP0005253_abnormal_eye_physiology1.19307582
48MP0010678_abnormal_skin_adnexa1.10732091
49MP0001529_abnormal_vocalization1.09374242
50MP0002254_reproductive_system_inflammat1.09325881
51MP0003195_calcinosis1.09107323
52MP0002210_abnormal_sex_determination1.08766596
53MP0002837_dystrophic_cardiac_calcinosis1.08510895
54MP0010094_abnormal_chromosome_stability1.06484450
55MP0003693_abnormal_embryo_hatching1.06025273
56MP0005379_endocrine/exocrine_gland_phen1.04885774
57MP0005167_abnormal_blood-brain_barrier1.04753442
58MP0005187_abnormal_penis_morphology1.04565221
59MP0008995_early_reproductive_senescence1.04261295
60MP0004270_analgesia1.03431777
61MP0002272_abnormal_nervous_system1.02109367
62MP0002160_abnormal_reproductive_system1.00979047
63MP0002233_abnormal_nose_morphology1.00770937
64MP0003011_delayed_dark_adaptation0.97192211
65MP0001905_abnormal_dopamine_level0.94632255
66MP0002734_abnormal_mechanical_nocicepti0.91884568
67MP0004133_heterotaxia0.91625295
68MP0006035_abnormal_mitochondrial_morpho0.91595235
69MP0003111_abnormal_nucleus_morphology0.89321869
70MP0002909_abnormal_adrenal_gland0.88939946
71MP0003943_abnormal_hepatobiliary_system0.88857782
72MP0006036_abnormal_mitochondrial_physio0.86186031
73MP0002095_abnormal_skin_pigmentation0.82873347
74MP0008057_abnormal_DNA_replication0.82778320
75MP0001346_abnormal_lacrimal_gland0.82132827
76MP0000647_abnormal_sebaceous_gland0.81271833
77MP0009250_abnormal_appendicular_skeleto0.79626693
78MP0002733_abnormal_thermal_nociception0.79553135
79MP0005389_reproductive_system_phenotype0.78439282
80MP0001243_abnormal_dermal_layer0.77294816
81MP0001919_abnormal_reproductive_system0.76974831
82MP0005408_hypopigmentation0.76871881
83MP0002751_abnormal_autonomic_nervous0.75292125
84MP0001929_abnormal_gametogenesis0.75286107
85MP0000653_abnormal_sex_gland0.73787179
86MP0001145_abnormal_male_reproductive0.73073925
87MP0003698_abnormal_male_reproductive0.71423794
88MP0000427_abnormal_hair_cycle0.71334745
89MP0002177_abnormal_outer_ear0.69999704
90MP0005395_other_phenotype0.68990719
91MP0005394_taste/olfaction_phenotype0.68027131
92MP0005499_abnormal_olfactory_system0.68027131
93MP0001790_abnormal_immune_system0.67622604
94MP0005387_immune_system_phenotype0.67622604
95MP0002084_abnormal_developmental_patter0.66774622
96MP0002693_abnormal_pancreas_physiology0.66009152
97MP0002928_abnormal_bile_duct0.65504926
98MP0003936_abnormal_reproductive_system0.65331513
99MP0001501_abnormal_sleep_pattern0.64635040
100MP0004036_abnormal_muscle_relaxation0.64199117

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.72774310
2Broad distal phalanx of finger (HP:0009836)3.67173339
3Concave nail (HP:0001598)3.36134247
4Abnormality of the labia minora (HP:0012880)3.33161929
53-Methylglutaconic aciduria (HP:0003535)3.08607841
6Megalencephaly (HP:0001355)3.05179915
7Synostosis involving the elbow (HP:0003938)2.90033112
8Humeroradial synostosis (HP:0003041)2.90033112
9Pancreatic fibrosis (HP:0100732)2.81304661
10Chronic diarrhea (HP:0002028)2.78344569
11Abnormality of the phalanges of the 2nd finger (HP:0009541)2.71445602
12Mitochondrial inheritance (HP:0001427)2.67901328
13Acute necrotizing encephalopathy (HP:0006965)2.58971188
14Hip dysplasia (HP:0001385)2.56400910
15Hepatocellular necrosis (HP:0001404)2.55545400
16Pancreatic cysts (HP:0001737)2.55466513
17Stomach cancer (HP:0012126)2.53741573
18Increased CSF lactate (HP:0002490)2.48398857
19Ependymoma (HP:0002888)2.36321975
20Increased serum lactate (HP:0002151)2.33340066
21Palpebral edema (HP:0100540)2.31871222
22Hepatic necrosis (HP:0002605)2.30245011
23Increased hepatocellular lipid droplets (HP:0006565)2.30205390
24Progressive macrocephaly (HP:0004481)2.27531504
25Abnormality of the astrocytes (HP:0100707)2.24411290
26Astrocytoma (HP:0009592)2.24411290
27Congenital stationary night blindness (HP:0007642)2.23613501
28Conical tooth (HP:0000698)2.22505266
29Cutaneous finger syndactyly (HP:0010554)2.22212855
30Abnormal number of erythroid precursors (HP:0012131)2.21985784
31Adactyly (HP:0009776)2.21214367
32Acute encephalopathy (HP:0006846)2.20125088
33Abnormality of the middle phalanges of the toes (HP:0010183)2.18855648
34Tubulointerstitial abnormality (HP:0001969)2.16003879
35Renal cortical cysts (HP:0000803)2.15748857
36Hypomagnesemia (HP:0002917)2.15688136
37Curly hair (HP:0002212)2.15150049
38Lipid accumulation in hepatocytes (HP:0006561)2.14750537
39Pendular nystagmus (HP:0012043)2.12841658
40Abnormality of the proximal phalanges of the hand (HP:0009834)2.12218151
41Hyperventilation (HP:0002883)2.11735107
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10517442
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10517442
44Abnormal mitochondria in muscle tissue (HP:0008316)2.10470545
45Polydipsia (HP:0001959)2.07640992
46Abnormal drinking behavior (HP:0030082)2.07640992
47Absent eyebrow (HP:0002223)2.06214351
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.05712410
49Nephronophthisis (HP:0000090)2.04520485
50True hermaphroditism (HP:0010459)2.04239898
51Abnormality of the renal cortex (HP:0011035)2.00460100
52Limb hypertonia (HP:0002509)1.99478648
53Decreased central vision (HP:0007663)1.98919342
54Aplasia/Hypoplasia of the tibia (HP:0005772)1.96077006
55Inappropriate behavior (HP:0000719)1.95306780
56Attenuation of retinal blood vessels (HP:0007843)1.94321597
57Glioma (HP:0009733)1.93768290
58Thin upper lip vermilion (HP:0000219)1.92772437
59Long nose (HP:0003189)1.90055327
60Distal arthrogryposis (HP:0005684)1.87955909
61Severe combined immunodeficiency (HP:0004430)1.85011240
62Abolished electroretinogram (ERG) (HP:0000550)1.84689409
63Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84540463
64Short 1st metacarpal (HP:0010034)1.84540463
65Cutaneous syndactyly (HP:0012725)1.84404428
66Exertional dyspnea (HP:0002875)1.81529966
67Abnormality of the pons (HP:0007361)1.78564360
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78536219
69Chronic hepatic failure (HP:0100626)1.78221835
70Bilateral microphthalmos (HP:0007633)1.78023709
71Broad-based gait (HP:0002136)1.77544999
72Aplasia/hypoplasia of the uterus (HP:0008684)1.77008211
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.76145423
74Increased corneal curvature (HP:0100692)1.75220713
75Keratoconus (HP:0000563)1.75220713
76Aplasia/Hypoplasia of the patella (HP:0006498)1.72799565
77Optic disc pallor (HP:0000543)1.71363186
78Anhidrosis (HP:0000970)1.70945048
79Congenital hepatic fibrosis (HP:0002612)1.69952043
80Fibular aplasia (HP:0002990)1.69843925
81Abnormality of methionine metabolism (HP:0010901)1.69587250
82Abnormality of cells of the erythroid lineage (HP:0012130)1.69047370
83Large for gestational age (HP:0001520)1.68559469
84Progressive microcephaly (HP:0000253)1.67251030
85Meckel diverticulum (HP:0002245)1.66921279
86Short tibia (HP:0005736)1.66567181
87Abnormality of the ileum (HP:0001549)1.66276634
88Small hand (HP:0200055)1.65909700
89Male pseudohermaphroditism (HP:0000037)1.65673269
90Renal hypoplasia (HP:0000089)1.65523678
91Type II lissencephaly (HP:0007260)1.65208089
92Abnormality of the preputium (HP:0100587)1.65163517
93Thyroiditis (HP:0100646)1.65112541
94Abnormality of the renal medulla (HP:0100957)1.64745654
95Fair hair (HP:0002286)1.64706203
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64124106
97CNS demyelination (HP:0007305)1.64070410
98Lactic acidosis (HP:0003128)1.63950488
99Postaxial foot polydactyly (HP:0001830)1.63134027
100Polyuria (HP:0000103)1.63086896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.47512339
2MAP4K23.18235928
3FRK2.99961606
4TLK12.91860118
5TSSK62.89222360
6WNK32.88218534
7TRIM282.60446846
8VRK22.50427778
9PBK2.50127896
10NUAK12.48385483
11VRK12.17207604
12BUB12.14727030
13EIF2AK12.08619344
14FGFR21.88976301
15SRPK11.83569411
16NEK11.82924550
17EIF2AK31.80641607
18PAK61.74563295
19PHKG11.69209154
20PHKG21.69209154
21MKNK11.57624650
22CCNB11.52021294
23BCKDK1.51014563
24CSNK1G11.45815149
25GRK11.43352555
26WNK41.41633199
27PINK11.38609381
28TNIK1.34376162
29CHEK21.33832260
30TAOK11.31217887
31ADRBK21.30191507
32BMPR1B1.25186090
33CSNK1G31.21020909
34EIF2AK21.20462194
35KSR11.16246629
36CASK1.13012256
37MAPK131.09599017
38PDK21.08920169
39PLK31.04874677
40MAPKAPK31.04568600
41TXK0.97538610
42TTK0.96145477
43STK38L0.94492476
44MKNK20.92344756
45CSNK1G20.89541651
46TAOK30.87342408
47PAK30.87095647
48CAMKK20.86298985
49SIK30.85967922
50IKBKB0.82622947
51CDC70.81885034
52MAP3K90.80151783
53CSNK1A1L0.77545707
54CLK10.75398795
55INSRR0.74392187
56STK160.73863650
57TAF10.71536973
58ITK0.68167141
59RAF10.67169641
60TEC0.67040890
61MAP2K70.66830619
62BRD40.62985633
63PRKAA20.62191870
64PRKCQ0.62133434
65DYRK20.61195051
66ALK0.60761128
67IRAK10.60652358
68NTRK30.60386581
69BRSK20.59451726
70MAP3K40.58578986
71CSNK1A10.58251375
72MST40.57281275
73KDR0.56616353
74OBSCN0.56477070
75DAPK10.56138453
76EPHA30.54670083
77CSNK1E0.54060394
78FGFR10.53842686
79ACVR1B0.53587983
80RPS6KA50.53356499
81STK240.51532149
82PLK10.51211121
83MAP3K140.50835385
84MARK30.49571779
85AURKB0.45127048
86BCR0.44867891
87KSR20.44062249
88AKT30.43986320
89ATM0.43950745
90CSNK2A20.43339197
91ATR0.41345207
92STK30.39813634
93PKN20.38979359
94SIK20.38871452
95TIE10.38064389
96SGK10.38034818
97PASK0.37674133
98TNK20.37330987
99MARK10.33061418
100PRKDC0.31721611

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40254943
2RNA polymerase_Homo sapiens_hsa030203.25246755
3Proteasome_Homo sapiens_hsa030503.11652356
4Parkinsons disease_Homo sapiens_hsa050122.62870918
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55699463
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53348966
7Vitamin B6 metabolism_Homo sapiens_hsa007502.50313220
8Oxidative phosphorylation_Homo sapiens_hsa001902.43387340
9Protein export_Homo sapiens_hsa030602.24185547
10Spliceosome_Homo sapiens_hsa030402.16542965
11RNA transport_Homo sapiens_hsa030132.13116668
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.12132761
13Ribosome_Homo sapiens_hsa030102.07615829
14Basal transcription factors_Homo sapiens_hsa030221.90215227
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79803916
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.75283819
17RNA degradation_Homo sapiens_hsa030181.70066304
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66733516
19Primary immunodeficiency_Homo sapiens_hsa053401.66133552
20Huntingtons disease_Homo sapiens_hsa050161.65743069
21Butanoate metabolism_Homo sapiens_hsa006501.64404115
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62813109
23Fanconi anemia pathway_Homo sapiens_hsa034601.56462236
24Phototransduction_Homo sapiens_hsa047441.47744434
25Linoleic acid metabolism_Homo sapiens_hsa005911.42310423
26Propanoate metabolism_Homo sapiens_hsa006401.42062232
27Homologous recombination_Homo sapiens_hsa034401.41435355
28Nitrogen metabolism_Homo sapiens_hsa009101.38712301
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34539718
30One carbon pool by folate_Homo sapiens_hsa006701.33645855
31Alzheimers disease_Homo sapiens_hsa050101.29503370
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28655753
33Asthma_Homo sapiens_hsa053101.26392040
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22257941
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21665729
36Allograft rejection_Homo sapiens_hsa053301.21580059
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19774516
38Systemic lupus erythematosus_Homo sapiens_hsa053221.18089005
39Alcoholism_Homo sapiens_hsa050341.15119012
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14111485
41Caffeine metabolism_Homo sapiens_hsa002321.12266737
42Autoimmune thyroid disease_Homo sapiens_hsa053201.11705772
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11499915
44Cardiac muscle contraction_Homo sapiens_hsa042601.09750389
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08583198
46Purine metabolism_Homo sapiens_hsa002301.06057456
47Nicotine addiction_Homo sapiens_hsa050331.01129801
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99910638
49Pyrimidine metabolism_Homo sapiens_hsa002400.99679387
50mRNA surveillance pathway_Homo sapiens_hsa030150.96925190
51Long-term depression_Homo sapiens_hsa047300.94877047
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.90542113
53Measles_Homo sapiens_hsa051620.87958187
54Ovarian steroidogenesis_Homo sapiens_hsa049130.86862863
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86771827
56Serotonergic synapse_Homo sapiens_hsa047260.83874076
57Taste transduction_Homo sapiens_hsa047420.82191553
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80475670
59Olfactory transduction_Homo sapiens_hsa047400.77868712
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77562795
61T cell receptor signaling pathway_Homo sapiens_hsa046600.74536099
62N-Glycan biosynthesis_Homo sapiens_hsa005100.73657214
63Regulation of autophagy_Homo sapiens_hsa041400.66894963
64Legionellosis_Homo sapiens_hsa051340.66850935
65Fatty acid metabolism_Homo sapiens_hsa012120.64177794
66TGF-beta signaling pathway_Homo sapiens_hsa043500.63867270
67p53 signaling pathway_Homo sapiens_hsa041150.62082632
68Tryptophan metabolism_Homo sapiens_hsa003800.61302351
69Ether lipid metabolism_Homo sapiens_hsa005650.59765148
70Insulin secretion_Homo sapiens_hsa049110.59234822
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51998141
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.51071880
73Oocyte meiosis_Homo sapiens_hsa041140.50805481
74Metabolic pathways_Homo sapiens_hsa011000.49676871
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48618537
76Mismatch repair_Homo sapiens_hsa034300.47564972
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46638151
78Base excision repair_Homo sapiens_hsa034100.46153310
79Tight junction_Homo sapiens_hsa045300.45465148
80Non-homologous end-joining_Homo sapiens_hsa034500.44143517
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43121666
82Fatty acid degradation_Homo sapiens_hsa000710.41903963
83Selenocompound metabolism_Homo sapiens_hsa004500.41198700
84Peroxisome_Homo sapiens_hsa041460.39844823
85Cocaine addiction_Homo sapiens_hsa050300.39567949
86Cell cycle_Homo sapiens_hsa041100.39209485
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38939743
88Hematopoietic cell lineage_Homo sapiens_hsa046400.36941879
89Morphine addiction_Homo sapiens_hsa050320.35161060
90Circadian rhythm_Homo sapiens_hsa047100.31015478
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30962175
92Folate biosynthesis_Homo sapiens_hsa007900.29461407
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28636826
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28385599
95DNA replication_Homo sapiens_hsa030300.28274295
96Type I diabetes mellitus_Homo sapiens_hsa049400.27471073
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.26656951
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26620987
99Viral carcinogenesis_Homo sapiens_hsa052030.25785033
100Oxytocin signaling pathway_Homo sapiens_hsa049210.25111382

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