ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	4.92693516
2	formation of translation preinitiation complex (GO:0001731)	4.49434166
3	ribosome assembly (GO:0042255)	4.41917995
4	ribosome biogenesis (GO:0042254)	4.23808168
5	pseudouridine synthesis (GO:0001522)	4.14226627
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.95872278
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.95872278
8	ribosomal large subunit biogenesis (GO:0042273)	3.84400129
9	ribonucleoprotein complex biogenesis (GO:0022613)	3.80326343
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.52770309
11	mitochondrial RNA metabolic process (GO:0000959)	3.38656042
12	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.38574125
13	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.38574125
14	isotype switching (GO:0045190)	3.38574125
15	cellular component biogenesis (GO:0044085)	3.36516984
16	GMP metabolic process (GO:0046037)	3.30267464
17	spliceosomal snRNP assembly (GO:0000387)	3.29855537
18	maturation of 5.8S rRNA (GO:0000460)	3.29690688
19	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.27014442
20	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.27014442
21	peptidyl-histidine modification (GO:0018202)	3.26856373
22	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.23246333
23	regulation of mitotic spindle checkpoint (GO:1903504)	3.23246333
24	proteasome assembly (GO:0043248)	3.22329914
25	protein deneddylation (GO:0000338)	3.21170124
26	rRNA catabolic process (GO:0016075)	3.20146828
27	maturation of SSU-rRNA (GO:0030490)	3.18101661
28	rRNA processing (GO:0006364)	3.17329962
29	cullin deneddylation (GO:0010388)	3.16752651
30	rRNA metabolic process (GO:0016072)	3.14437200
31	translational initiation (GO:0006413)	3.13880691
32	establishment of integrated proviral latency (GO:0075713)	3.12583875
33	ubiquinone biosynthetic process (GO:0006744)	3.10334807
34	translation (GO:0006412)	3.09754358
35	tRNA aminoacylation for protein translation (GO:0006418)	3.09577283
36	transcription from mitochondrial promoter (GO:0006390)	3.09513921
37	metallo-sulfur cluster assembly (GO:0031163)	3.07852019
38	iron-sulfur cluster assembly (GO:0016226)	3.07852019
39	ubiquinone metabolic process (GO:0006743)	3.07420922
40	tRNA aminoacylation (GO:0043039)	3.04643908
41	amino acid activation (GO:0043038)	3.04643908
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04144458
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.01572669
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01345339
45	translational elongation (GO:0006414)	3.00062244
46	regulation of centriole replication (GO:0046599)	2.98704031
47	termination of RNA polymerase I transcription (GO:0006363)	2.97015737
48	7-methylguanosine mRNA capping (GO:0006370)	2.96557644
49	preassembly of GPI anchor in ER membrane (GO:0016254)	2.92914384
50	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.92671895
51	branched-chain amino acid catabolic process (GO:0009083)	2.92357574
52	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92241646
53	DNA strand elongation involved in DNA replication (GO:0006271)	2.91286828
54	tRNA metabolic process (GO:0006399)	2.91247217
55	DNA ligation (GO:0006266)	2.91147851
56	somatic diversification of immunoglobulins (GO:0016445)	2.90879997
57	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.90560712
58	7-methylguanosine RNA capping (GO:0009452)	2.87510036
59	RNA capping (GO:0036260)	2.87510036
60	ribosomal small subunit biogenesis (GO:0042274)	2.87445736
61	IMP biosynthetic process (GO:0006188)	2.87390074
62	regulation of translational termination (GO:0006449)	2.87364653
63	tRNA processing (GO:0008033)	2.86293235
64	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.85946756
65	DNA excision (GO:0044349)	2.85946756
66	DNA deamination (GO:0045006)	2.85240087
67	rRNA modification (GO:0000154)	2.84539091
68	L-serine metabolic process (GO:0006563)	2.83681967
69	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.81226606
70	establishment of viral latency (GO:0019043)	2.81115360
71	viral transcription (GO:0019083)	2.80965758
72	termination of RNA polymerase III transcription (GO:0006386)	2.80575421
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.80575421
74	IMP metabolic process (GO:0046040)	2.80500271
75	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.80125835
76	ncRNA metabolic process (GO:0034660)	2.80122155
77	tRNA modification (GO:0006400)	2.79630327
78	DNA strand elongation (GO:0022616)	2.79578228
79	translational termination (GO:0006415)	2.79363742
80	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.78907902
81	regulation of isotype switching to IgG isotypes (GO:0048302)	2.78722649
82	ncRNA processing (GO:0034470)	2.76157143
83	cotranslational protein targeting to membrane (GO:0006613)	2.74762347
84	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.73727632
85	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.72122451
86	protein targeting to ER (GO:0045047)	2.71058991
87	respiratory chain complex IV assembly (GO:0008535)	2.69886722
88	pore complex assembly (GO:0046931)	2.68853707
89	guanosine-containing compound biosynthetic process (GO:1901070)	2.67296135
90	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.66079733
91	somatic diversification of immune receptors (GO:0002200)	2.65799773
92	regulation of mitochondrial translation (GO:0070129)	2.65779904
93	amino acid salvage (GO:0043102)	2.65437279
94	L-methionine salvage (GO:0071267)	2.65437279
95	L-methionine biosynthetic process (GO:0071265)	2.65437279
96	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.65012222
97	protein targeting to mitochondrion (GO:0006626)	2.62423817
98	non-recombinational repair (GO:0000726)	2.61926076
99	double-strand break repair via nonhomologous end joining (GO:0006303)	2.61926076
100	ribonucleoprotein complex assembly (GO:0022618)	2.61754674

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.79837085
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.44926214
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.91694560
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.74219676
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.69951418
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.61233483
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.58875302
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.43679926
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.14914193
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12929201
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.04095760
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.97079608
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88514461
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85161892
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.81833364
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.77691862
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.77115688
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.61935254
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.52676167
20	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.46393245
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.36551926
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.34124001
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.24933461
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.24727259
25	XRN2_22483619_ChIP-Seq_HELA_Human	2.20099114
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.18586758
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.15058241
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13778736
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.11377299
30	GABP_19822575_ChIP-Seq_HepG2_Human	2.10516319
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.10149029
32	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.05125784
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.04297129
34	TTF2_22483619_ChIP-Seq_HELA_Human	2.04064673
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.96174478
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.95073234
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.94052945
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.90894512
39	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.87590050
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.87548964
41	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.87073426
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.82995661
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.82797888
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82105014
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.79224719
46	KDM5A_27292631_Chip-Seq_BREAST_Human	1.79136954
47	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.74466255
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.68374989
49	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.62183982
50	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51264542
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.49631286
52	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48881048
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.47498409
54	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.47308845
55	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45723620
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.45173965
57	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.41358827
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.39173814
59	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38528289
60	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.37531547
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37473555
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.37452391
63	TFEB_21752829_ChIP-Seq_HELA_Human	1.36906487
64	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34047600
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.33329773
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.32780803
67	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.26324225
68	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.25768761
69	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.25321415
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24389689
71	IGF1R_20145208_ChIP-Seq_DFB_Human	1.20156992
72	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.19773434
73	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.18483561
74	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.16268607
75	SPI1_23547873_ChIP-Seq_NB4_Human	1.10231373
76	ELF5_23300383_ChIP-Seq_T47D_Human	1.04231223
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03382400
78	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02485717
79	FUS_26573619_Chip-Seq_HEK293_Human	1.01221985
80	MYB_26560356_Chip-Seq_TH2_Human	1.00157594
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.96393937
82	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.95299386
83	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89491246
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89206717
85	GATA3_26560356_Chip-Seq_TH2_Human	0.87504345
86	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.85516357
87	MYC_22102868_ChIP-Seq_BL_Human	0.84994894
88	EWS_26573619_Chip-Seq_HEK293_Human	0.84845511
89	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84178281
90	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.80902081
91	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.78557077
92	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.77658588
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.77409680
94	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.76578048
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.73689583
96	VDR_22108803_ChIP-Seq_LS180_Human	0.73498115
97	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.72240602
98	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.69987392
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.68792899
100	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.68372299

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	4.15268588
2	MP0010094_abnormal_chromosome_stability	4.07850290
3	MP0003693_abnormal_embryo_hatching	3.85993601
4	MP0004957_abnormal_blastocyst_morpholog	3.26118583
5	MP0001986_abnormal_taste_sensitivity	3.06504440
6	MP0003111_abnormal_nucleus_morphology	3.00004754
7	MP0002138_abnormal_hepatobiliary_system	2.96559526
8	MP0003786_premature_aging	2.93654501
9	MP0002163_abnormal_gland_morphology	2.55142648
10	MP0002009_preneoplasia	2.52806331
11	MP0003077_abnormal_cell_cycle	2.45586601
12	MP0006072_abnormal_retinal_apoptosis	2.40948713
13	MP0002166_altered_tumor_susceptibility	2.24612206
14	MP0006035_abnormal_mitochondrial_morpho	2.24189689
15	MP0003221_abnormal_cardiomyocyte_apopto	2.14614655
16	MP0002006_tumorigenesis	1.99923714
17	MP0005084_abnormal_gallbladder_morpholo	1.93554567
18	MP0003763_abnormal_thymus_physiology	1.92713992
19	MP0002102_abnormal_ear_morphology	1.82665080
20	MP0005671_abnormal_response_to	1.82226211
21	MP0008875_abnormal_xenobiotic_pharmacok	1.77299665
22	MP0003718_maternal_effect	1.69456410
23	MP0008932_abnormal_embryonic_tissue	1.68221614
24	MP0000685_abnormal_immune_system	1.62104496
25	MP0001348_abnormal_lacrimal_gland	1.58869181
26	MP0003806_abnormal_nucleotide_metabolis	1.54666869
27	MP0000358_abnormal_cell_content/	1.44439794
28	MP0000313_abnormal_cell_death	1.44087535
29	MP0001730_embryonic_growth_arrest	1.44078578
30	MP0005645_abnormal_hypothalamus_physiol	1.43507849
31	MP0001764_abnormal_homeostasis	1.41317797
32	MP0001661_extended_life_span	1.41203140
33	MP0008877_abnormal_DNA_methylation	1.40197222
34	MP0008007_abnormal_cellular_replicative	1.39559033
35	MP0005379_endocrine/exocrine_gland_phen	1.38360537
36	MP0002019_abnormal_tumor_incidence	1.37598725
37	MP0002277_abnormal_respiratory_mucosa	1.36671659
38	MP0008057_abnormal_DNA_replication	1.33637469
39	MP0001800_abnormal_humoral_immune	1.32958030
40	MP0006036_abnormal_mitochondrial_physio	1.31715992
41	MP0008995_early_reproductive_senescence	1.31667447
42	MP0000750_abnormal_muscle_regeneration	1.30299341
43	MP0001243_abnormal_dermal_layer	1.27811768
44	MP0008872_abnormal_physiological_respon	1.23912470
45	MP0000747_muscle_weakness	1.23630327
46	MP0000689_abnormal_spleen_morphology	1.22496051
47	MP0004145_abnormal_muscle_electrophysio	1.17359960
48	MP0000703_abnormal_thymus_morphology	1.16477857
49	MP0004147_increased_porphyrin_level	1.14664732
50	MP0002722_abnormal_immune_system	1.14173889
51	MP0000013_abnormal_adipose_tissue	1.13855427
52	MP0002398_abnormal_bone_marrow	1.13326763
53	MP0001919_abnormal_reproductive_system	1.13124877
54	MP0005000_abnormal_immune_tolerance	1.12476507
55	MP0002254_reproductive_system_inflammat	1.12086728
56	MP0001873_stomach_inflammation	1.11654159
57	MP0001529_abnormal_vocalization	1.09968928
58	MP0009333_abnormal_splenocyte_physiolog	1.07103546
59	MP0003787_abnormal_imprinting	1.06365743
60	MP0002723_abnormal_immune_serum	1.05959677
61	MP0001293_anophthalmia	1.03040651
62	MP0002452_abnormal_antigen_presenting	1.02702172
63	MP0002396_abnormal_hematopoietic_system	1.00169466
64	MP0005075_abnormal_melanosome_morpholog	0.99099758
65	MP0001819_abnormal_immune_cell	0.98604646
66	MP0002148_abnormal_hypersensitivity_rea	0.96853253
67	MP0002420_abnormal_adaptive_immunity	0.95978992
68	MP0000350_abnormal_cell_proliferation	0.95720507
69	MP0001835_abnormal_antigen_presentation	0.95150544
70	MP0010234_abnormal_vibrissa_follicle	0.90741834
71	MP0002269_muscular_atrophy	0.89951221
72	MP0003724_increased_susceptibility_to	0.89308883
73	MP0004197_abnormal_fetal_growth/weight/	0.89143817
74	MP0000427_abnormal_hair_cycle	0.88351785
75	MP0005380_embryogenesis_phenotype	0.88161496
76	MP0001672_abnormal_embryogenesis/_devel	0.88161496
77	MP0003656_abnormal_erythrocyte_physiolo	0.87871379
78	MP0001790_abnormal_immune_system	0.87326169
79	MP0005387_immune_system_phenotype	0.87326169
80	MP0009764_decreased_sensitivity_to	0.86390894
81	MP0001188_hyperpigmentation	0.85592551
82	MP0001697_abnormal_embryo_size	0.85283391
83	MP0008789_abnormal_olfactory_epithelium	0.85122618
84	MP0002429_abnormal_blood_cell	0.84728094
85	MP0005332_abnormal_amino_acid	0.84488094
86	MP0009379_abnormal_foot_pigmentation	0.83980750
87	MP0005646_abnormal_pituitary_gland	0.82899315
88	MP0002080_prenatal_lethality	0.82560087
89	MP0005501_abnormal_skin_physiology	0.79046825
90	MP0000716_abnormal_immune_system	0.78876570
91	MP0005253_abnormal_eye_physiology	0.78364511
92	MP0001929_abnormal_gametogenesis	0.74923403
93	MP0003984_embryonic_growth_retardation	0.73979948
94	MP0009697_abnormal_copulation	0.73599948
95	MP0002693_abnormal_pancreas_physiology	0.73268125
96	MP0002084_abnormal_developmental_patter	0.72954462
97	MP0002139_abnormal_hepatobiliary_system	0.72739849
98	MP0005389_reproductive_system_phenotype	0.71651534
99	MP0003186_abnormal_redox_activity	0.71635564
100	MP0003866_abnormal_defecation	0.71151572

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	3.53961450
2	3-Methylglutaconic aciduria (HP:0003535)	3.45161075
3	Increased serum lactate (HP:0002151)	3.30622010
4	Lipid accumulation in hepatocytes (HP:0006561)	3.28055498
5	IgM deficiency (HP:0002850)	3.23421632
6	Increased hepatocellular lipid droplets (HP:0006565)	3.22312392
7	Microvesicular hepatic steatosis (HP:0001414)	3.21773951
8	Colon cancer (HP:0003003)	3.01208677
9	Increased CSF lactate (HP:0002490)	2.95721386
10	Pancreatic cysts (HP:0001737)	2.87080258
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84787330
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84787330
13	Aplasia/hypoplasia of the uterus (HP:0008684)	2.83796576
14	Acute encephalopathy (HP:0006846)	2.75583755
15	Carpal bone hypoplasia (HP:0001498)	2.75230747
16	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.67278971
17	Mitochondrial inheritance (HP:0001427)	2.64706530
18	Acute necrotizing encephalopathy (HP:0006965)	2.64585793
19	Lactic acidosis (HP:0003128)	2.64485851
20	Increased intramyocellular lipid droplets (HP:0012240)	2.51712467
21	Abnormality of the pons (HP:0007361)	2.45763544
22	Severe combined immunodeficiency (HP:0004430)	2.45625553
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.45072210
24	Abnormal protein glycosylation (HP:0012346)	2.44035634
25	Abnormal glycosylation (HP:0012345)	2.44035634
26	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.44035634
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.44035634
28	Renal cortical cysts (HP:0000803)	2.43119992
29	Reticulocytopenia (HP:0001896)	2.41093227
30	Hyperglycinemia (HP:0002154)	2.37812670
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.37384622
32	Oral leukoplakia (HP:0002745)	2.32450895
33	Unilateral renal agenesis (HP:0000122)	2.31458880
34	Bile duct proliferation (HP:0001408)	2.30749339
35	Abnormal biliary tract physiology (HP:0012439)	2.30749339
36	Abnormality of T cell physiology (HP:0011840)	2.28582071
37	Hepatic necrosis (HP:0002605)	2.28234456
38	B lymphocytopenia (HP:0010976)	2.27949046
39	Hepatocellular necrosis (HP:0001404)	2.26420303
40	Abnormality of B cell number (HP:0010975)	2.25459179
41	Delayed CNS myelination (HP:0002188)	2.24942128
42	Abnormal number of erythroid precursors (HP:0012131)	2.24269310
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24225379
44	Prostate neoplasm (HP:0100787)	2.21163576
45	Lethargy (HP:0001254)	2.20959389
46	Methylmalonic acidemia (HP:0002912)	2.19509664
47	Postnatal microcephaly (HP:0005484)	2.17988402
48	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.16884245
49	Fibular aplasia (HP:0002990)	2.15929078
50	Increased muscle lipid content (HP:0009058)	2.12986534
51	Hypoplasia of the uterus (HP:0000013)	2.12811964
52	Type II lissencephaly (HP:0007260)	2.12123655
53	Type 2 muscle fiber atrophy (HP:0003554)	2.11847468
54	Fatigue (HP:0012378)	2.10183053
55	Meckel diverticulum (HP:0002245)	2.10096871
56	Horseshoe kidney (HP:0000085)	2.09786884
57	Tubulointerstitial nephritis (HP:0001970)	2.09461720
58	Cerebral edema (HP:0002181)	2.09067614
59	Entropion (HP:0000621)	2.07933205
60	Exercise intolerance (HP:0003546)	2.07134617
61	Abnormality of the ileum (HP:0001549)	2.06298098
62	Combined immunodeficiency (HP:0005387)	2.05925139
63	Hypoplasia of the pons (HP:0012110)	2.04755851
64	Progressive macrocephaly (HP:0004481)	2.02914684
65	Abnormality of the preputium (HP:0100587)	2.01995445
66	Progressive inability to walk (HP:0002505)	1.98903712
67	Renal Fanconi syndrome (HP:0001994)	1.98366207
68	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.96817267
69	Progressive muscle weakness (HP:0003323)	1.96768098
70	Type I transferrin isoform profile (HP:0003642)	1.95170259
71	Stomach cancer (HP:0012126)	1.94881844
72	Abnormality of the prostate (HP:0008775)	1.94354466
73	Abnormality of glycine metabolism (HP:0010895)	1.94154319
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.94154319
75	Abnormality of T cells (HP:0002843)	1.90982748
76	Redundant skin (HP:0001582)	1.89343146
77	Congenital stationary night blindness (HP:0007642)	1.89253640
78	Muscle fiber atrophy (HP:0100295)	1.87929305
79	Cerebral hypomyelination (HP:0006808)	1.87461139
80	Ependymoma (HP:0002888)	1.86225396
81	Gonadotropin excess (HP:0000837)	1.85431654
82	Progressive microcephaly (HP:0000253)	1.85254904
83	Pancreatic fibrosis (HP:0100732)	1.85090767
84	Abnormality of DNA repair (HP:0003254)	1.85013726
85	Myoglobinuria (HP:0002913)	1.84399071
86	Eosinophilia (HP:0001880)	1.84197886
87	Ulnar deviation of the wrist (HP:0003049)	1.83929249
88	Hyperammonemia (HP:0001987)	1.83748681
89	Absent thumb (HP:0009777)	1.83149405
90	Hyperglycinuria (HP:0003108)	1.82562879
91	Aplasia/hypoplasia of the humerus (HP:0006507)	1.82403666
92	Brittle hair (HP:0002299)	1.81792870
93	Respiratory difficulties (HP:0002880)	1.81655957
94	Death in infancy (HP:0001522)	1.81629125
95	Myelodysplasia (HP:0002863)	1.81609698
96	Cerebral palsy (HP:0100021)	1.81525350
97	Rhabdomyolysis (HP:0003201)	1.80941788
98	Abnormality of methionine metabolism (HP:0010901)	1.79842953
99	Pancytopenia (HP:0001876)	1.79557452
100	Granulocytopenia (HP:0001913)	1.78171507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SRPK1	4.36865330
2	ZAK	3.68784064
3	MAP4K2	3.24262821
4	TLK1	2.81512315
5	BUB1	2.71150021
6	VRK2	2.64744088
7	TRIM28	2.64374383
8	TSSK6	2.56741370
9	STK16	2.53909837
10	NEK1	2.45594042
11	NUAK1	2.41313574
12	PBK	2.26811297
13	EIF2AK3	2.26706814
14	BCR	2.22144161
15	MKNK1	2.15201576
16	MAP3K14	1.87831477
17	BCKDK	1.75949269
18	PASK	1.67439656
19	CDC7	1.66423075
20	TXK	1.61022644
21	MST4	1.57797171
22	SCYL2	1.49610678
23	MAP2K2	1.45631978
24	RPS6KA4	1.43837803
25	MAP2K7	1.41803433
26	NME2	1.37017606
27	PLK3	1.28401174
28	CSNK1G3	1.26264399
29	TAF1	1.25186173
30	MAP3K4	1.21751157
31	ADRBK2	1.20379154
32	NEK2	1.17008828
33	MAP4K1	1.16545625
34	STK38L	1.15204415
35	RPS6KB2	1.14736136
36	VRK1	1.14647929
37	TIE1	1.12025249
38	TTK	1.11986168
39	IKBKB	1.11075846
40	BRD4	1.10884624
41	PHKG1	1.06213555
42	PHKG2	1.06213555
43	CSNK1G1	1.03044729
44	MAP3K13	1.00465153
45	SMG1	0.98150199
46	EIF2AK2	0.96683992
47	TAOK3	0.95836764
48	WNK4	0.95344936
49	GRK6	0.94102801
50	ERBB3	0.91259005
51	NME1	0.91044982
52	MAP3K9	0.88545944
53	PLK1	0.87108614
54	EIF2AK1	0.85924568
55	AURKB	0.85650714
56	ATR	0.82484577
57	CCNB1	0.77209908
58	CSNK1G2	0.76618091
59	CSNK1A1L	0.75405360
60	GRK1	0.71485652
61	PDK2	0.71145294
62	MAPKAPK5	0.68390109
63	PLK4	0.67581838
64	RPS6KA5	0.66169940
65	CSNK2A2	0.66033176
66	CHEK2	0.65990729
67	CDK4	0.65946425
68	ALK	0.64267958
69	MAPKAPK3	0.64263470
70	TESK2	0.60981579
71	CDK7	0.58966688
72	STK24	0.58511552
73	RPS6KB1	0.56599086
74	TEC	0.56050026
75	MKNK2	0.54559491
76	TBK1	0.51945679
77	AURKA	0.50348684
78	CSNK2A1	0.50126822
79	ATM	0.47754390
80	EEF2K	0.47686994
81	ITK	0.46951376
82	SIK3	0.43958544
83	CSNK1E	0.43224478
84	CHEK1	0.42512735
85	WNK3	0.42140137
86	PRKCI	0.37212557
87	IRAK4	0.37200799
88	PRKCQ	0.35952577
89	PIK3CG	0.35772951
90	MAPK11	0.35458811
91	CSF1R	0.34928963
92	CDK9	0.34601357
93	MAP2K6	0.32467134
94	KDR	0.32226471
95	DAPK1	0.31265678
96	CDK6	0.30775538
97	BTK	0.29915450
98	IRAK2	0.29215239
99	JAK3	0.28314140
100	CDK8	0.27552724

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.42238365
2	Ribosome_Homo sapiens_hsa03010	3.25305282
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.10945685
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.95471794
5	Mismatch repair_Homo sapiens_hsa03430	2.84412710
6	RNA polymerase_Homo sapiens_hsa03020	2.80227723
7	DNA replication_Homo sapiens_hsa03030	2.77255127
8	RNA transport_Homo sapiens_hsa03013	2.75297273
9	Spliceosome_Homo sapiens_hsa03040	2.63462548
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.57531406
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.45354782
12	Basal transcription factors_Homo sapiens_hsa03022	2.38283304
13	One carbon pool by folate_Homo sapiens_hsa00670	2.32679153
14	Base excision repair_Homo sapiens_hsa03410	2.16011058
15	RNA degradation_Homo sapiens_hsa03018	2.07332907
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06502974
17	Homologous recombination_Homo sapiens_hsa03440	1.97354451
18	Protein export_Homo sapiens_hsa03060	1.96608481
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90893126
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84242697
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.83627466
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.70383043
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67395431
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62282185
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61555982
26	Propanoate metabolism_Homo sapiens_hsa00640	1.60622001
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.55882620
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54830055
29	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.49432808
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.44191961
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.42655344
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.41645182
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.41366145
34	Primary immunodeficiency_Homo sapiens_hsa05340	1.38826916
35	Purine metabolism_Homo sapiens_hsa00230	1.38592813
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.34995870
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.33520022
38	Allograft rejection_Homo sapiens_hsa05330	1.32418686
39	Parkinsons disease_Homo sapiens_hsa05012	1.27109865
40	Carbon metabolism_Homo sapiens_hsa01200	1.26824211
41	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.21595749
42	Asthma_Homo sapiens_hsa05310	1.20718414
43	Butanoate metabolism_Homo sapiens_hsa00650	1.17627404
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17568307
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16821919
46	mRNA surveillance pathway_Homo sapiens_hsa03015	1.13491273
47	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02380643
48	Huntingtons disease_Homo sapiens_hsa05016	0.93838184
49	Cell cycle_Homo sapiens_hsa04110	0.93548637
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.88798542
51	Sulfur metabolism_Homo sapiens_hsa00920	0.88184957
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.85147151
53	Herpes simplex infection_Homo sapiens_hsa05168	0.82993535
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.72621574
55	Peroxisome_Homo sapiens_hsa04146	0.64741545
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.63935238
57	Glutathione metabolism_Homo sapiens_hsa00480	0.63278768
58	Fatty acid elongation_Homo sapiens_hsa00062	0.62729195
59	Alzheimers disease_Homo sapiens_hsa05010	0.58850835
60	p53 signaling pathway_Homo sapiens_hsa04115	0.57360894
61	Metabolic pathways_Homo sapiens_hsa01100	0.56418494
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56364713
63	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.55970213
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55202697
65	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.53697636
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52861861
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.52123896
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.49948623
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49378880
70	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.48872762
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47634244
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47426620
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.46902103
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46735769
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46249459
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44563580
77	Regulation of autophagy_Homo sapiens_hsa04140	0.43060397
78	Shigellosis_Homo sapiens_hsa05131	0.40447284
79	Sulfur relay system_Homo sapiens_hsa04122	0.40423166
80	Viral myocarditis_Homo sapiens_hsa05416	0.40168284
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.39338292
82	Measles_Homo sapiens_hsa05162	0.39032933
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38433650
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.37575717
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.37262756
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36561063
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30146793
88	Nitrogen metabolism_Homo sapiens_hsa00910	0.29385624
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.26867058
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.25024007
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22960158
92	Oocyte meiosis_Homo sapiens_hsa04114	0.18848417
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18418557
94	Phototransduction_Homo sapiens_hsa04744	0.18286127
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.18140832
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.16934502
97	Apoptosis_Homo sapiens_hsa04210	0.13089643
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.12400425
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.12108217
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.10132870

EIF4BP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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