EIF4BP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)8.61930594
2plasma membrane fusion (GO:0045026)8.45241510
3DNA packaging (GO:0006323)8.29678099
4sperm capacitation (GO:0048240)8.15047447
5protein targeting to Golgi (GO:0000042)8.04052423
6microtubule depolymerization (GO:0007019)8.01642075
7rRNA methylation (GO:0031167)8.00467685
8establishment of protein localization to Golgi (GO:0072600)7.77504100
9protein polyglutamylation (GO:0018095)7.67909526
10single strand break repair (GO:0000012)7.65170827
11response to pheromone (GO:0019236)7.62515075
12spermatid development (GO:0007286)7.60747950
13retrograde transport, vesicle recycling within Golgi (GO:0000301)7.44572480
14sperm-egg recognition (GO:0035036)7.19034281
15microtubule polymerization or depolymerization (GO:0031109)7.18992454
16spermatid nucleus differentiation (GO:0007289)7.14526162
17multicellular organism reproduction (GO:0032504)6.99617133
18rRNA modification (GO:0000154)6.76416646
19spermatogenesis (GO:0007283)6.43431150
20male gamete generation (GO:0048232)6.41254341
21centriole replication (GO:0007099)6.40829093
22reproduction (GO:0000003)6.36653965
23binding of sperm to zona pellucida (GO:0007339)6.29960912
24axonemal dynein complex assembly (GO:0070286)6.29040349
25calcium ion-dependent exocytosis (GO:0017156)6.28816585
26seminiferous tubule development (GO:0072520)6.12524691
27regulation of centriole replication (GO:0046599)6.03654217
28protein localization to Golgi apparatus (GO:0034067)6.01280099
29cell-cell recognition (GO:0009988)5.91016756
30gamete generation (GO:0007276)5.87687015
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.85840928
32RNA destabilization (GO:0050779)5.69137691
33centriole assembly (GO:0098534)5.63389923
34phosphatidylethanolamine metabolic process (GO:0046337)5.61408624
35sexual reproduction (GO:0019953)5.55660173
36motile cilium assembly (GO:0044458)5.55291507
37single fertilization (GO:0007338)5.24696829
38microtubule severing (GO:0051013)5.21704577
39cilium or flagellum-dependent cell motility (GO:0001539)5.00836468
40negative regulation of inclusion body assembly (GO:0090084)4.99770316
41regulation of Rab GTPase activity (GO:0032313)4.86629062
42positive regulation of Rab GTPase activity (GO:0032851)4.86629062
43epithelial cilium movement (GO:0003351)4.75618575
44multicellular organismal reproductive process (GO:0048609)4.66956010
45regulation of cilium movement (GO:0003352)4.62490510
46fertilization (GO:0009566)4.54123558
47germ cell development (GO:0007281)4.37013209
48glomerular visceral epithelial cell development (GO:0072015)4.36536520
49cell wall macromolecule catabolic process (GO:0016998)4.35505318
50cellular ketone body metabolic process (GO:0046950)4.35024544
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29401830
52regulation of transcription involved in cell fate commitment (GO:0060850)4.26561788
53cell wall macromolecule metabolic process (GO:0044036)4.22540907
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.17244184
55musculoskeletal movement (GO:0050881)4.16012670
56multicellular organismal movement (GO:0050879)4.16012670
57nucleus organization (GO:0006997)4.11725214
58glomerular epithelial cell development (GO:0072310)4.06354381
59cilium movement (GO:0003341)4.04793440
60microtubule nucleation (GO:0007020)3.91744288
61ketone body metabolic process (GO:1902224)3.81857410
62glycerol ether metabolic process (GO:0006662)3.71402149
63chromatin silencing (GO:0006342)3.69127024
64regulation of inclusion body assembly (GO:0090083)3.58915498
65ether metabolic process (GO:0018904)3.41449589
66membrane protein intracellular domain proteolysis (GO:0031293)3.35843627
67tRNA methylation (GO:0030488)3.34249465
68axoneme assembly (GO:0035082)3.31538849
69intra-Golgi vesicle-mediated transport (GO:0006891)3.22386843
70organic cation transport (GO:0015695)3.22112430
71negative regulation of Rho protein signal transduction (GO:0035024)3.18520763
72peptidyl-threonine dephosphorylation (GO:0035970)3.18221557
73RNA methylation (GO:0001510)3.15778421
74piRNA metabolic process (GO:0034587)3.10285593
75positive regulation of guanylate cyclase activity (GO:0031284)3.09742817
76regulation of interleukin-13 production (GO:0032656)3.04909954
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01195340
78coenzyme catabolic process (GO:0009109)2.98889754
79multicellular organismal development (GO:0007275)2.96016537
80detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.95097200
81nuclear pore complex assembly (GO:0051292)2.94869549
82male meiosis I (GO:0007141)2.93891625
83DNA methylation involved in gamete generation (GO:0043046)2.93238522
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92833935
85male meiosis (GO:0007140)2.89974896
86regulation of guanylate cyclase activity (GO:0031282)2.88506060
87homeostasis of number of cells within a tissue (GO:0048873)2.83528598
88regulation of T-helper 2 cell differentiation (GO:0045628)2.79805037
89NAD biosynthetic process (GO:0009435)2.76637179
90mast cell activation involved in immune response (GO:0002279)2.75781075
91mast cell degranulation (GO:0043303)2.75781075
92protein depolymerization (GO:0051261)2.75702411
93Golgi to endosome transport (GO:0006895)2.75414718
94cell recognition (GO:0008037)2.75289823
95ventricular system development (GO:0021591)2.71225004
96cerebral cortex neuron differentiation (GO:0021895)2.70651022
97cell differentiation involved in metanephros development (GO:0072202)2.69758590
98sperm motility (GO:0030317)11.8652165
99fusion of sperm to egg plasma membrane (GO:0007342)11.1721922
100acrosome reaction (GO:0007340)11.0995891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.93515375
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.17638248
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.57362273
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43340331
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43340331
6FUS_26573619_Chip-Seq_HEK293_Human2.30766552
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29211368
8CBP_20019798_ChIP-Seq_JUKART_Human2.28482487
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.28482487
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24654666
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.19786551
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18930644
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13145307
14RAC3_21632823_ChIP-Seq_H3396_Human2.00066652
15ELF1_20517297_ChIP-Seq_JURKAT_Human1.99549785
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92021995
17ERA_21632823_ChIP-Seq_H3396_Human1.90717623
18EZH2_22144423_ChIP-Seq_EOC_Human1.84844549
19WDR5_24793694_ChIP-Seq_LNCAP_Human1.83690353
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82393161
21EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81606983
22DROSHA_22980978_ChIP-Seq_HELA_Human1.80560865
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76331029
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74722294
25ZNF274_21170338_ChIP-Seq_K562_Hela1.72932704
26MYC_19829295_ChIP-Seq_ESCs_Human1.72591684
27ER_23166858_ChIP-Seq_MCF-7_Human1.72402931
28NANOG_20526341_ChIP-Seq_ESCs_Human1.71898523
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.69125478
30TAF2_19829295_ChIP-Seq_ESCs_Human1.69101860
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67316841
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65260078
33BCL6_27268052_Chip-Seq_Bcells_Human1.64072783
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.56717457
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56038736
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.55183145
37RBPJ_21746931_ChIP-Seq_IB4_Human1.53362700
38CBX2_22325352_ChIP-Seq_293T-Rex_Human1.52494497
39CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.51166229
40OCT4_20526341_ChIP-Seq_ESCs_Human1.47781212
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46478255
42ERG_20517297_ChIP-Seq_VCAP_Human1.46326541
43E2F1_20622854_ChIP-Seq_HELA_Human1.46250941
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45849160
45ETV1_20927104_ChIP-Seq_GIST48_Human1.45585307
46CTCF_20526341_ChIP-Seq_ESCs_Human1.44921185
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.43525473
48CTCF_27219007_Chip-Seq_Bcells_Human1.43110589
49BCOR_27268052_Chip-Seq_Bcells_Human1.41907778
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41761854
51P300_19829295_ChIP-Seq_ESCs_Human1.41582050
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.39796215
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39666475
54PHF8_20622854_ChIP-Seq_HELA_Human1.39324864
55P300_27268052_Chip-Seq_Bcells_Human1.36822719
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.36103758
57NFYB_21822215_ChIP-Seq_K562_Human1.34865553
58PHF8_20622853_ChIP-Seq_HELA_Human1.34691457
59CEBPB_22108803_ChIP-Seq_LS180_Human1.33784455
60AR_25329375_ChIP-Seq_VCAP_Human1.32433163
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.31527210
62P68_20966046_ChIP-Seq_HELA_Human1.30507290
63TBL1_22424771_ChIP-Seq_293T_Human1.29519259
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.29072616
65TP63_22573176_ChIP-Seq_HFKS_Human1.27723936
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.27274335
67P53_21459846_ChIP-Seq_SAOS-2_Human1.26349466
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26102205
69TAF15_26573619_Chip-Seq_HEK293_Human1.25811706
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25583873
71SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23564693
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23194656
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.23145236
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.21898586
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21250294
76NANOG_19829295_ChIP-Seq_ESCs_Human1.20184242
77SOX2_19829295_ChIP-Seq_ESCs_Human1.20184242
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18539274
79RUNX_20019798_ChIP-Seq_JUKART_Human1.18504392
80SMC4_20622854_ChIP-Seq_HELA_Human1.16082782
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15847612
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15655487
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15184357
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.15184357
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.14398306
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13686519
87AR_21572438_ChIP-Seq_LNCaP_Human1.12451829
88NFYA_21822215_ChIP-Seq_K562_Human1.09278985
89HOXB7_26014856_ChIP-Seq_BT474_Human1.08742108
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07973744
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06476648
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06226982
93FOXH1_21741376_ChIP-Seq_EPCs_Human1.05494435
94SA1_27219007_Chip-Seq_Bcells_Human1.05058070
95STAT3_23295773_ChIP-Seq_U87_Human1.04895068
96TP53_18474530_ChIP-ChIP_U2OS_Human1.04651107
97VDR_22108803_ChIP-Seq_LS180_Human1.04278908
98SPI1_20517297_ChIP-Seq_HL60_Human1.03690071
99RUNX2_22187159_ChIP-Seq_PCA_Human1.03655081
100NCOR_22424771_ChIP-Seq_293T_Human1.03144206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.68769460
2MP0005377_hearing/vestibular/ear_phenot5.68769460
3MP0003698_abnormal_male_reproductive4.13780184
4MP0005670_abnormal_white_adipose3.97740258
5MP0001929_abnormal_gametogenesis3.63918595
6MP0001348_abnormal_lacrimal_gland3.41160919
7MP0003646_muscle_fatigue2.46569485
8MP0003718_maternal_effect2.45140158
9MP0005451_abnormal_body_composition2.26710677
10MP0002161_abnormal_fertility/fecundity2.19272874
11MP0005379_endocrine/exocrine_gland_phen2.04045674
12MP0005410_abnormal_fertilization11.2280499
13MP0004742_abnormal_vestibular_system1.88179455
14MP0001486_abnormal_startle_reflex1.78033659
15MP0000678_abnormal_parathyroid_gland1.74292409
16MP0002210_abnormal_sex_determination1.70746593
17MP0001485_abnormal_pinna_reflex1.70401183
18MP0002132_abnormal_respiratory_system1.60085519
19MP0005310_abnormal_salivary_gland1.52224142
20MP0003011_delayed_dark_adaptation1.48888161
21MP0002234_abnormal_pharynx_morphology1.44890238
22MP0002822_catalepsy1.40620315
23MP0001145_abnormal_male_reproductive1.40484834
24MP0000653_abnormal_sex_gland1.34155388
25MP0009053_abnormal_anal_canal1.31498930
26MP0002282_abnormal_trachea_morphology1.26761553
27MP0005423_abnormal_somatic_nervous1.26669931
28MP0003879_abnormal_hair_cell1.23063746
29MP0005551_abnormal_eye_electrophysiolog1.21042855
30MP0005253_abnormal_eye_physiology1.14871369
31MP0001765_abnormal_ion_homeostasis1.14809799
32MP0001963_abnormal_hearing_physiology1.12074774
33MP0005645_abnormal_hypothalamus_physiol1.06842683
34MP0009697_abnormal_copulation1.06617050
35MP0009115_abnormal_fat_cell1.05726104
36MP0005395_other_phenotype1.04226759
37MP0008877_abnormal_DNA_methylation1.03779003
38MP0008789_abnormal_olfactory_epithelium1.03247573
39MP0002653_abnormal_ependyma_morphology1.02744235
40MP0000026_abnormal_inner_ear0.99899344
41MP0006292_abnormal_olfactory_placode0.98306674
42MP0005084_abnormal_gallbladder_morpholo0.95204222
43MP0002735_abnormal_chemical_nociception0.93691796
44MP0005167_abnormal_blood-brain_barrier0.92835539
45MP0009278_abnormal_bone_marrow0.88172363
46MP0005397_hematopoietic_system_phenotyp0.83254072
47MP0001545_abnormal_hematopoietic_system0.83254072
48MP0002229_neurodegeneration0.83152857
49MP0001968_abnormal_touch/_nociception0.82045991
50MP0001501_abnormal_sleep_pattern0.81722724
51MP0002138_abnormal_hepatobiliary_system0.78459317
52MP0005636_abnormal_mineral_homeostasis0.78237802
53MP0005394_taste/olfaction_phenotype0.76757500
54MP0005499_abnormal_olfactory_system0.76757500
55MP0002733_abnormal_thermal_nociception0.75778279
56MP0004085_abnormal_heartbeat0.75064294
57MP0002067_abnormal_sensory_capabilities0.74712522
58MP0002127_abnormal_cardiovascular_syste0.72794728
59MP0005083_abnormal_biliary_tract0.72518312
60MP0001984_abnormal_olfaction0.71286732
61MP0002557_abnormal_social/conspecific_i0.69578578
62MP0008995_early_reproductive_senescence0.68019157
63MP0004859_abnormal_synaptic_plasticity0.67834781
64MP0001905_abnormal_dopamine_level0.67538001
65MP0000955_abnormal_spinal_cord0.67063571
66MP0000230_abnormal_systemic_arterial0.63913358
67MP0002572_abnormal_emotion/affect_behav0.63449357
68MP0008569_lethality_at_weaning0.62061063
69MP0002249_abnormal_larynx_morphology0.59630341
70MP0008961_abnormal_basal_metabolism0.55534996
71MP0009764_decreased_sensitivity_to0.53811876
72MP0003137_abnormal_impulse_conducting0.53609729
73MP0005391_vision/eye_phenotype0.53107701
74MP0002254_reproductive_system_inflammat0.50710827
75MP0001666_abnormal_nutrient_absorption0.50608951
76MP0000534_abnormal_ureter_morphology0.50416228
77MP0002272_abnormal_nervous_system0.49610367
78MP0005535_abnormal_body_temperature0.49566039
79MP0004510_myositis0.49544675
80MP0001440_abnormal_grooming_behavior0.49396279
81MP0005408_hypopigmentation0.47915491
82MP0005332_abnormal_amino_acid0.46865169
83MP0010329_abnormal_lipoprotein_level0.46746414
84MP0002928_abnormal_bile_duct0.46139476
85MP0005666_abnormal_adipose_tissue0.45135753
86MP0001970_abnormal_pain_threshold0.44214062
87MP0003936_abnormal_reproductive_system0.43001975
88MP0009745_abnormal_behavioral_response0.42934592
89MP0006072_abnormal_retinal_apoptosis0.42244158
90MP0005646_abnormal_pituitary_gland0.39843816
91MP0003880_abnormal_central_pattern0.38561549
92MP0002269_muscular_atrophy0.37712537
93MP0005595_abnormal_vascular_smooth0.36866538
94MP0003077_abnormal_cell_cycle0.36654527
95MP0006276_abnormal_autonomic_nervous0.36510261
96MP0000049_abnormal_middle_ear0.36455702
97MP0004036_abnormal_muscle_relaxation0.35113446
98MP0008872_abnormal_physiological_respon0.35014942
99MP0001270_distended_abdomen0.34907739
100MP0000470_abnormal_stomach_morphology0.34296658

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.68796654
2Absent/shortened dynein arms (HP:0200106)6.40222666
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.40222666
4Tubulointerstitial nephritis (HP:0001970)6.01677705
5Chronic hepatic failure (HP:0100626)5.75303096
6Asymmetric septal hypertrophy (HP:0001670)5.55891143
7Attenuation of retinal blood vessels (HP:0007843)5.15744428
8Bony spicule pigmentary retinopathy (HP:0007737)5.02678035
9Abnormal ciliary motility (HP:0012262)4.51847654
10Abnormal respiratory motile cilium physiology (HP:0012261)4.33169779
11Nasal polyposis (HP:0100582)4.20634602
12Hyperkalemia (HP:0002153)4.19643582
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.17511003
14Abnormal respiratory epithelium morphology (HP:0012253)4.14734298
15Abnormal respiratory motile cilium morphology (HP:0005938)4.14734298
16Cone-rod dystrophy (HP:0000548)4.13929561
17Abnormal rod and cone electroretinograms (HP:0008323)4.01221829
18Abnormality of macular pigmentation (HP:0008002)3.87866766
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.83163781
20Male infertility (HP:0003251)3.74986014
21Hypoplasia of the thymus (HP:0000778)3.70247043
22Infertility (HP:0000789)3.67281295
23Impulsivity (HP:0100710)3.58706288
24Resting tremor (HP:0002322)3.56189428
25Menstrual irregularities (HP:0000858)3.52585644
26Abnormality of the nasal mucosa (HP:0000433)3.41683157
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.41583247
28Abnormality of dental color (HP:0011073)3.37767030
29Amelogenesis imperfecta (HP:0000705)3.29572610
30Facial shape deformation (HP:0011334)3.24512395
31Potter facies (HP:0002009)3.24512395
32Progressive cerebellar ataxia (HP:0002073)3.24255950
33Nephronophthisis (HP:0000090)3.07490269
34Hypoalphalipoproteinemia (HP:0003233)3.07373951
35Abnormal spermatogenesis (HP:0008669)3.04106925
36Tubulointerstitial abnormality (HP:0001969)3.01079644
37Stage 5 chronic kidney disease (HP:0003774)2.92856145
38Abnormality of the renal medulla (HP:0100957)2.92254663
39Abnormal urine output (HP:0012590)2.89893953
40Abnormal drinking behavior (HP:0030082)2.89252091
41Polydipsia (HP:0001959)2.89252091
42Portal hypertension (HP:0001409)2.87673981
43Progressive sensorineural hearing impairment (HP:0000408)2.83011345
44Generalized aminoaciduria (HP:0002909)2.82907098
45Bell-shaped thorax (HP:0001591)2.80847417
46Rhinitis (HP:0012384)2.76308873
47Enlarged epiphyses (HP:0010580)2.76013726
48Insulin-resistant diabetes mellitus (HP:0000831)2.74461520
49Postural instability (HP:0002172)2.61815181
50Azoospermia (HP:0000027)2.61653173
51Polyuria (HP:0000103)2.61577945
52Abnormality of the hepatic vasculature (HP:0006707)2.61256472
53Abnormality of the costochondral junction (HP:0000919)2.57338950
54Decreased central vision (HP:0007663)2.54173456
55Abnormality of potassium homeostasis (HP:0011042)2.49624912
56Truncal obesity (HP:0001956)2.46796703
57Abnormality of renal excretion (HP:0011036)2.44605695
58Chronic bronchitis (HP:0004469)2.43355897
59Hypoplastic ischia (HP:0003175)2.38574527
60Type 2 muscle fiber atrophy (HP:0003554)2.34229164
61Renal dysplasia (HP:0000110)2.23629617
62Muscle fiber atrophy (HP:0100295)2.23556038
63Increased purine levels (HP:0004368)2.20940646
64Hyperuricemia (HP:0002149)2.20940646
65Renovascular hypertension (HP:0100817)2.16392779
66Renal Fanconi syndrome (HP:0001994)2.14474160
67Flat capital femoral epiphysis (HP:0003370)2.11884487
68Abnormality of the aortic arch (HP:0012303)2.11797537
69Focal segmental glomerulosclerosis (HP:0000097)2.06488679
70Intellectual disability, moderate (HP:0002342)2.03800406
71Pendular nystagmus (HP:0012043)2.02192329
72Abnormality of the ischium (HP:0003174)2.01162793
73Hyponatremia (HP:0002902)1.97008778
74Optic nerve hypoplasia (HP:0000609)1.96891647
75Failure to thrive in infancy (HP:0001531)1.95088485
76Bronchiectasis (HP:0002110)1.94956825
77Photophobia (HP:0000613)1.93413576
78Subcapsular cataract (HP:0000523)1.92705996
79Recurrent pneumonia (HP:0006532)1.91611160
80Abnormality of the epiphysis of the femoral head (HP:0010574)1.89717162
81Flattened epiphyses (HP:0003071)1.83796003
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83449179
83Glomerulosclerosis (HP:0000096)1.83348240
84Hypoalbuminemia (HP:0003073)1.79233051
85Abnormal albumin level (HP:0012116)1.79233051
86Cerebellar dysplasia (HP:0007033)1.78429146
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77713290
88Unilateral renal agenesis (HP:0000122)1.76544553
89Tetany (HP:0001281)1.76389299
90Abnormality of urine glucose concentration (HP:0011016)1.74658227
91Glycosuria (HP:0003076)1.74658227
92Ventricular tachycardia (HP:0004756)1.74446199
93Type II diabetes mellitus (HP:0005978)1.73411619
94Abnormality of femoral epiphyses (HP:0006499)1.72507256
95Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72507256
96Congenital sensorineural hearing impairment (HP:0008527)1.72277848
97Fatigable weakness (HP:0003473)1.71263564
98Abnormality of the neuromuscular junction (HP:0003398)1.71263564
99Horizontal nystagmus (HP:0000666)1.71122695
100Pancreatic fibrosis (HP:0100732)1.70855441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.16117650
2INSRR5.22799176
3BRD44.24291689
4TESK14.24127223
5PLK23.36205125
6MAP4K23.28706184
7DDR23.07261547
8PIK3CG2.38103928
9PNCK2.36845138
10STK382.34259353
11CAMK1G2.32761132
12TXK2.19154349
13MAPK151.80554555
14STK38L1.78545387
15MAP2K21.60452719
16PTK2B1.52756095
17TAOK31.39478069
18PDK11.33058232
19TYRO31.27927210
20WNK11.21755408
21PDPK11.12885968
22CAMK1D1.12310537
23NEK61.05465871
24TESK21.04635306
25WNK41.03289666
26NUAK11.00866721
27MST1R0.96330932
28PRKD30.95127809
29DYRK1B0.92710818
30CDK120.91012206
31TIE10.87936221
32TLK10.84972973
33CDK70.83245031
34JAK30.82399894
35ZAK0.80933681
36IKBKB0.80450587
37BRSK20.77276730
38STK390.74549160
39MAP3K110.73075200
40KIT0.65774575
41MAPK110.60313073
42RPS6KA10.59849860
43PRKAA20.59077384
44BRSK10.56928745
45MAP3K90.55645324
46ICK0.53091071
47KDR0.51929202
48CAMK10.51091931
49TAF10.50246665
50RPS6KA60.47902958
51OXSR10.47864215
52IKBKE0.47761691
53RPS6KC10.47326848
54RPS6KL10.47326848
55RPS6KA20.46931510
56PRKG10.44645598
57SIK20.43393984
58PRKG20.42683753
59TBK10.42370933
60MAPKAPK50.40345352
61TNK20.40057051
62MAPK10.36560407
63BMPR1B0.35642671
64AKT30.35063327
65ADRBK20.35028773
66TEC0.34197842
67PRKCZ0.33264366
68FRK0.33122047
69CDK190.29947202
70CDK30.29467599
71CDK20.29241749
72CAMKK20.28477328
73MAP4K10.28459549
74SYK0.27898018
75MAP2K10.27870246
76PRKCG0.27389362
77CDK10.27383754
78GSK3B0.27251957
79BLK0.25902329
80KSR20.25587291
81CHEK10.24241591
82SGK10.23876871
83PRKCQ0.23025292
84LATS10.21947822
85PRKCB0.21548531
86CAMK40.21399648
87ROCK10.20472810
88VRK10.19884077
89NTRK30.18930301
90MAPK80.18831283
91MUSK0.17619107
92CDK90.17310373
93FLT30.17236973
94MAP3K130.16442489
95GRK10.14834294
96DYRK1A0.13116447
97UHMK10.13058661
98MAPK140.13004328
99AKT10.12677989
100MAP3K70.10738498

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.98310054
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.89158664
3Olfactory transduction_Homo sapiens_hsa047404.17556725
4Allograft rejection_Homo sapiens_hsa053302.74559853
5Autoimmune thyroid disease_Homo sapiens_hsa053202.68609861
6Graft-versus-host disease_Homo sapiens_hsa053322.56656789
7Type I diabetes mellitus_Homo sapiens_hsa049402.52396687
8Butanoate metabolism_Homo sapiens_hsa006502.37393675
9RNA transport_Homo sapiens_hsa030132.26148380
10Phototransduction_Homo sapiens_hsa047442.21972643
11Antigen processing and presentation_Homo sapiens_hsa046122.05291587
12Glycerophospholipid metabolism_Homo sapiens_hsa005642.02473845
13Taste transduction_Homo sapiens_hsa047421.78638886
14Viral myocarditis_Homo sapiens_hsa054161.76464455
15Fatty acid degradation_Homo sapiens_hsa000711.54775827
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50994311
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43641983
18Fatty acid metabolism_Homo sapiens_hsa012121.39182307
19Phenylalanine metabolism_Homo sapiens_hsa003601.35416545
20Fat digestion and absorption_Homo sapiens_hsa049751.26377185
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.25800810
22Linoleic acid metabolism_Homo sapiens_hsa005911.19712261
23Protein digestion and absorption_Homo sapiens_hsa049741.19282984
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.17469393
25Type II diabetes mellitus_Homo sapiens_hsa049301.11511256
26Fanconi anemia pathway_Homo sapiens_hsa034601.10177730
27Influenza A_Homo sapiens_hsa051641.08443990
28Nitrogen metabolism_Homo sapiens_hsa009101.05151535
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03242409
30Cardiac muscle contraction_Homo sapiens_hsa042601.03180278
31Dorso-ventral axis formation_Homo sapiens_hsa043201.00172882
32Asthma_Homo sapiens_hsa053100.99852865
33Adipocytokine signaling pathway_Homo sapiens_hsa049200.98367562
34Glycerolipid metabolism_Homo sapiens_hsa005610.97467331
35Salivary secretion_Homo sapiens_hsa049700.94499532
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94187683
37ABC transporters_Homo sapiens_hsa020100.94094654
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.94047765
39Arginine and proline metabolism_Homo sapiens_hsa003300.93902705
40Nicotine addiction_Homo sapiens_hsa050330.92004804
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90156545
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86884488
43Inositol phosphate metabolism_Homo sapiens_hsa005620.85857078
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85488903
45Morphine addiction_Homo sapiens_hsa050320.84334901
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81765720
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79641272
48Calcium signaling pathway_Homo sapiens_hsa040200.79534445
49Basal transcription factors_Homo sapiens_hsa030220.78538157
50Retinol metabolism_Homo sapiens_hsa008300.77742710
51Purine metabolism_Homo sapiens_hsa002300.71872383
52Base excision repair_Homo sapiens_hsa034100.71725203
53Selenocompound metabolism_Homo sapiens_hsa004500.70640395
54Propanoate metabolism_Homo sapiens_hsa006400.69845249
55Tyrosine metabolism_Homo sapiens_hsa003500.69133646
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68941519
57Huntingtons disease_Homo sapiens_hsa050160.67305114
58Herpes simplex infection_Homo sapiens_hsa051680.66964507
59Endocytosis_Homo sapiens_hsa041440.65441698
60Serotonergic synapse_Homo sapiens_hsa047260.64414341
61Tryptophan metabolism_Homo sapiens_hsa003800.62255013
62Primary immunodeficiency_Homo sapiens_hsa053400.60614945
63Pancreatic secretion_Homo sapiens_hsa049720.58113609
64Glutamatergic synapse_Homo sapiens_hsa047240.56040356
65Renin secretion_Homo sapiens_hsa049240.55359904
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50260355
67Sulfur relay system_Homo sapiens_hsa041220.48992563
68PPAR signaling pathway_Homo sapiens_hsa033200.47719184
69cAMP signaling pathway_Homo sapiens_hsa040240.46343101
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.44775406
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.44760843
72Arginine biosynthesis_Homo sapiens_hsa002200.43749716
73Chemical carcinogenesis_Homo sapiens_hsa052040.43592281
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42011730
75Vitamin B6 metabolism_Homo sapiens_hsa007500.41802996
76VEGF signaling pathway_Homo sapiens_hsa043700.39206776
77Synaptic vesicle cycle_Homo sapiens_hsa047210.39117049
78Legionellosis_Homo sapiens_hsa051340.39112924
79Metabolic pathways_Homo sapiens_hsa011000.38794183
80Circadian entrainment_Homo sapiens_hsa047130.38701831
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38234097
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35508152
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.34229719
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34157661
85Renin-angiotensin system_Homo sapiens_hsa046140.33952833
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33906473
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33273779
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31821732
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29245717
90Hematopoietic cell lineage_Homo sapiens_hsa046400.29235299
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26861498
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26351111
93MAPK signaling pathway_Homo sapiens_hsa040100.26212547
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24590901
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23385422
96Biosynthesis of amino acids_Homo sapiens_hsa012300.23322839
97Vitamin digestion and absorption_Homo sapiens_hsa049770.23169393
98Measles_Homo sapiens_hsa051620.22886544
99Peroxisome_Homo sapiens_hsa041460.22011581
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21656816

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