ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.40996672
2	rRNA methylation (GO:0031167)	5.28411795
3	proteasome assembly (GO:0043248)	4.98827703
4	rRNA modification (GO:0000154)	4.90032312
5	cellular response to exogenous dsRNA (GO:0071360)	4.33651493
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.25635981
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.14542082
8	retinal cone cell development (GO:0046549)	4.08315831
9	positive regulation of mitochondrial fission (GO:0090141)	4.07144639
10	cullin deneddylation (GO:0010388)	4.07108721
11	negative regulation of mast cell activation (GO:0033004)	4.06138245
12	ATP synthesis coupled proton transport (GO:0015986)	3.92012851
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.92012851
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91651957
15	cellular response to interferon-beta (GO:0035458)	3.85349949
16	tyrosine phosphorylation of STAT protein (GO:0007260)	3.81541324
17	protein deneddylation (GO:0000338)	3.81482609
18	DNA integration (GO:0015074)	3.65541408
19	organelle disassembly (GO:1903008)	3.41082422
20	inner mitochondrial membrane organization (GO:0007007)	3.39650987
21	purine-containing compound salvage (GO:0043101)	3.38420460
22	iron-sulfur cluster assembly (GO:0016226)	3.35672963
23	metallo-sulfur cluster assembly (GO:0031163)	3.35672963
24	DNA deamination (GO:0045006)	3.34374539
25	lactate metabolic process (GO:0006089)	3.33801362
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31017135
27	DNA double-strand break processing (GO:0000729)	3.11649114
28	RNA methylation (GO:0001510)	2.98747967
29	brain morphogenesis (GO:0048854)	2.98636838
30	response to X-ray (GO:0010165)	2.95830456
31	protein polyglutamylation (GO:0018095)	2.92800094
32	regulation of mitochondrial fission (GO:0090140)	2.88354754
33	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.87457549
34	cellular response to dsRNA (GO:0071359)	2.86283173
35	response to interferon-beta (GO:0035456)	2.83915582
36	peroxisome fission (GO:0016559)	2.83283323
37	positive regulation of prostaglandin secretion (GO:0032308)	2.82218443
38	tolerance induction (GO:0002507)	2.78995771
39	tRNA processing (GO:0008033)	2.78819761
40	regulation of cilium movement (GO:0003352)	2.77378908
41	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.74583195
42	response to xenobiotic stimulus (GO:0009410)	2.73115442
43	maternal behavior (GO:0042711)	2.72955381
44	electron transport chain (GO:0022900)	2.72683091
45	respiratory electron transport chain (GO:0022904)	2.72648925
46	negative regulation of thymocyte apoptotic process (GO:0070244)	2.72191184
47	protein complex biogenesis (GO:0070271)	2.70362780
48	reciprocal DNA recombination (GO:0035825)	2.69969253
49	reciprocal meiotic recombination (GO:0007131)	2.69969253
50	DNA catabolic process, exonucleolytic (GO:0000738)	2.68277358
51	respiratory chain complex IV assembly (GO:0008535)	2.67166162
52	kinetochore organization (GO:0051383)	2.67158564
53	GMP metabolic process (GO:0046037)	2.67074262
54	aldehyde catabolic process (GO:0046185)	2.63953080
55	detection of temperature stimulus (GO:0016048)	2.63926050
56	negative regulation of telomere maintenance (GO:0032205)	2.63689682
57	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.63231689
58	regulation of meiosis I (GO:0060631)	2.63202035
59	synaptonemal complex organization (GO:0070193)	2.63160989
60	AMP metabolic process (GO:0046033)	2.62029549
61	serotonin receptor signaling pathway (GO:0007210)	2.61468421
62	positive regulation of glycolytic process (GO:0045821)	2.60457148
63	tRNA metabolic process (GO:0006399)	2.60158313
64	protein peptidyl-prolyl isomerization (GO:0000413)	2.58930592
65	negative regulation of acute inflammatory response (GO:0002674)	2.58138324
66	parental behavior (GO:0060746)	2.57707285
67	sequestering of actin monomers (GO:0042989)	2.57327280
68	synaptonemal complex assembly (GO:0007130)	2.54163092
69	tRNA methylation (GO:0030488)	2.53121952
70	establishment of integrated proviral latency (GO:0075713)	2.52603289
71	positive regulation of steroid hormone secretion (GO:2000833)	2.51462527
72	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.50511919
73	negative regulation of neurological system process (GO:0031645)	2.49787544
74	spliceosomal complex assembly (GO:0000245)	2.49667379
75	kinetochore assembly (GO:0051382)	2.49424080
76	termination of RNA polymerase I transcription (GO:0006363)	2.48517568
77	RNA-dependent DNA replication (GO:0006278)	2.48319140
78	protein-cofactor linkage (GO:0018065)	2.48262664
79	viral mRNA export from host cell nucleus (GO:0046784)	2.48134679
80	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.45024708
81	chaperone-mediated protein transport (GO:0072321)	2.44630391
82	organelle membrane fusion (GO:0090174)	2.44561970
83	tRNA aminoacylation for protein translation (GO:0006418)	2.44557888
84	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.42862036
85	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.42862036
86	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.42862036
87	mitochondrial RNA metabolic process (GO:0000959)	2.41613267
88	pseudouridine synthesis (GO:0001522)	2.40874829
89	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.39716286
90	tRNA aminoacylation (GO:0043039)	2.39322912
91	amino acid activation (GO:0043038)	2.39322912
92	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.38982494
93	telomere maintenance via telomerase (GO:0007004)	2.38743686
94	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.37442867
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.36989078
96	isotype switching (GO:0045190)	2.36989078
97	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.36989078
98	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.36491036
99	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.36420419
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.36402557

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.20853777
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.75359582
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.35199949
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.23183645
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.00533020
6	VDR_22108803_ChIP-Seq_LS180_Human	3.70311158
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.69317123
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.48541724
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.73938258
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52550909
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51614772
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39364847
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.32914876
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.26610464
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.14828385
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13280708
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.11791072
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09323096
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00111349
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95863832
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.89568462
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77830036
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.74818878
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68459752
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68404644
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.67593304
27	EWS_26573619_Chip-Seq_HEK293_Human	1.66771337
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65328305
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62905800
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.62035031
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56809748
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55542462
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54757945
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50398747
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40630667
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35138615
37	FUS_26573619_Chip-Seq_HEK293_Human	1.35104297
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32426814
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30869515
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30837696
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.30837696
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.30666013
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26184992
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25717512
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25717512
46	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25007291
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24711817
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.24535924
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.23976979
50	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.21463746
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20072855
52	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19722800
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19700745
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19700745
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17164080
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16467799
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.14938627
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14522004
59	TTF2_22483619_ChIP-Seq_HELA_Human	1.14328223
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11238363
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09267668
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08515394
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.08056363
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07762444
65	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.07383260
66	GATA3_26560356_Chip-Seq_TH2_Human	1.06774919
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06706698
68	AR_20517297_ChIP-Seq_VCAP_Human	1.05961171
69	E2F7_22180533_ChIP-Seq_HELA_Human	1.05286745
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05071269
71	P300_19829295_ChIP-Seq_ESCs_Human	1.04722824
72	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04623870
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04377772
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.04050798
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03698322
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03656458
77	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03578803
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03218788
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02522752
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01552238
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.01201310
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99942067
83	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99438046
84	SPI1_23547873_ChIP-Seq_NB4_Human	0.98785891
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98623973
86	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96959919
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96905321
88	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94809186
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.94617417
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94376249
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93518380
92	P300_18555785_Chip-Seq_ESCs_Mouse	0.93269903
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91938486
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.91420896
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90168795
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90103936
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.89801637
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89047365
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.88053467
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.87949146

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	5.15631148
2	MP0008058_abnormal_DNA_repair	3.34389299
3	MP0005084_abnormal_gallbladder_morpholo	3.17293444
4	MP0000372_irregular_coat_pigmentation	3.15369385
5	MP0001986_abnormal_taste_sensitivity	2.90143252
6	MP0003724_increased_susceptibility_to	2.76948640
7	MP0002166_altered_tumor_susceptibility	2.49740407
8	MP0006072_abnormal_retinal_apoptosis	2.41168352
9	MP0002006_tumorigenesis	2.40500820
10	MP0003806_abnormal_nucleotide_metabolis	2.35209118
11	MP0005075_abnormal_melanosome_morpholog	2.17491111
12	MP0010094_abnormal_chromosome_stability	2.05146034
13	MP0003718_maternal_effect	2.04819265
14	MP0000015_abnormal_ear_pigmentation	2.02958221
15	MP0003693_abnormal_embryo_hatching	1.77285132
16	MP0004147_increased_porphyrin_level	1.76436014
17	MP0006036_abnormal_mitochondrial_physio	1.75958658
18	MP0001984_abnormal_olfaction	1.74435773
19	MP0006035_abnormal_mitochondrial_morpho	1.72159776
20	MP0003787_abnormal_imprinting	1.71917819
21	MP0002837_dystrophic_cardiac_calcinosis	1.69543915
22	MP0003121_genomic_imprinting	1.67946233
23	MP0005367_renal/urinary_system_phenotyp	1.65817610
24	MP0000516_abnormal_urinary_system	1.65817610
25	MP0005379_endocrine/exocrine_gland_phen	1.63738271
26	MP0005174_abnormal_tail_pigmentation	1.62462342
27	MP0008872_abnormal_physiological_respon	1.60338281
28	MP0005671_abnormal_response_to	1.59853458
29	MP0003786_premature_aging	1.59509275
30	MP0009379_abnormal_foot_pigmentation	1.57164654
31	MP0000569_abnormal_digit_pigmentation	1.57107698
32	MP0008995_early_reproductive_senescence	1.56372005
33	MP0001188_hyperpigmentation	1.55870070
34	MP0003195_calcinosis	1.49957965
35	MP0006292_abnormal_olfactory_placode	1.48776257
36	MP0004142_abnormal_muscle_tone	1.47661185
37	MP0002822_catalepsy	1.43983568
38	MP0010234_abnormal_vibrissa_follicle	1.39849036
39	MP0001919_abnormal_reproductive_system	1.39733179
40	MP0003136_yellow_coat_color	1.33413239
41	MP0001502_abnormal_circadian_rhythm	1.28429574
42	MP0003252_abnormal_bile_duct	1.25772905
43	MP0005253_abnormal_eye_physiology	1.24222006
44	MP0008877_abnormal_DNA_methylation	1.24009142
45	MP0002090_abnormal_vision	1.18724404
46	MP0002102_abnormal_ear_morphology	1.14451261
47	MP0005389_reproductive_system_phenotype	1.13816466
48	MP0001970_abnormal_pain_threshold	1.11436395
49	MP0005408_hypopigmentation	1.08874441
50	MP0001440_abnormal_grooming_behavior	1.08467333
51	MP0006276_abnormal_autonomic_nervous	1.08134444
52	MP0001905_abnormal_dopamine_level	1.07766732
53	MP0005451_abnormal_body_composition	1.05014494
54	MP0004957_abnormal_blastocyst_morpholog	1.04116962
55	MP0001727_abnormal_embryo_implantation	1.03491740
56	MP0008007_abnormal_cellular_replicative	1.01501498
57	MP0002733_abnormal_thermal_nociception	1.01176015
58	MP0001968_abnormal_touch/_nociception	1.00981846
59	MP0009333_abnormal_splenocyte_physiolog	1.00921615
60	MP0002254_reproductive_system_inflammat	0.98745800
61	MP0002095_abnormal_skin_pigmentation	0.98586012
62	MP0000427_abnormal_hair_cycle	0.96686288
63	MP0002272_abnormal_nervous_system	0.95649557
64	MP0000013_abnormal_adipose_tissue	0.95098031
65	MP0005551_abnormal_eye_electrophysiolog	0.94557764
66	MP0005636_abnormal_mineral_homeostasis	0.94269965
67	MP0004924_abnormal_behavior	0.93330998
68	MP0005386_behavior/neurological_phenoty	0.93330998
69	MP0004885_abnormal_endolymph	0.93170011
70	MP0001545_abnormal_hematopoietic_system	0.92328988
71	MP0005397_hematopoietic_system_phenotyp	0.92328988
72	MP0002396_abnormal_hematopoietic_system	0.90621436
73	MP0002210_abnormal_sex_determination	0.86345141
74	MP0001177_atelectasis	0.83350884
75	MP0009785_altered_susceptibility_to	0.81679750
76	MP0003866_abnormal_defecation	0.80563893
77	MP0005167_abnormal_blood-brain_barrier	0.80498629
78	MP0002163_abnormal_gland_morphology	0.77865371
79	MP0001765_abnormal_ion_homeostasis	0.77445987
80	MP0002572_abnormal_emotion/affect_behav	0.77388511
81	MP0001145_abnormal_male_reproductive	0.77005175
82	MP0001929_abnormal_gametogenesis	0.76861621
83	MP0005464_abnormal_platelet_physiology	0.76645717
84	MP0008775_abnormal_heart_ventricle	0.76352023
85	MP0001800_abnormal_humoral_immune	0.75802958
86	MP0002452_abnormal_antigen_presenting	0.74570406
87	MP0003111_abnormal_nucleus_morphology	0.74044525
88	MP0000627_abnormal_mammary_gland	0.73117865
89	MP0004145_abnormal_muscle_electrophysio	0.72810541
90	MP0002909_abnormal_adrenal_gland	0.72770819
91	MP0003763_abnormal_thymus_physiology	0.72627037
92	MP0002148_abnormal_hypersensitivity_rea	0.71015004
93	MP0003646_muscle_fatigue	0.70146186
94	MP0002938_white_spotting	0.69040881
95	MP0002751_abnormal_autonomic_nervous	0.68180738
96	MP0001529_abnormal_vocalization	0.67630989
97	MP0005085_abnormal_gallbladder_physiolo	0.66515100
98	MP0009697_abnormal_copulation	0.66311366
99	MP0005535_abnormal_body_temperature	0.65964357
100	MP0004742_abnormal_vestibular_system	0.65356589

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.93574764
2	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.03333175
3	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.03333175
4	Unilateral renal agenesis (HP:0000122)	3.72029795
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.68017256
6	Increased intramyocellular lipid droplets (HP:0012240)	3.42400619
7	Shoulder girdle muscle weakness (HP:0003547)	3.24648702
8	Pelvic girdle muscle weakness (HP:0003749)	3.21025344
9	Exertional dyspnea (HP:0002875)	3.04995205
10	Increased hepatocellular lipid droplets (HP:0006565)	3.01008683
11	Abnormality of the musculature of the pelvis (HP:0001469)	3.00133430
12	Abnormality of the hip-girdle musculature (HP:0001445)	3.00133430
13	Abnormality of methionine metabolism (HP:0010901)	2.93246600
14	Pancreatic cysts (HP:0001737)	2.75999497
15	Resting tremor (HP:0002322)	2.74783743
16	Adactyly (HP:0009776)	2.74317910
17	Abolished electroretinogram (ERG) (HP:0000550)	2.72698230
18	Medial flaring of the eyebrow (HP:0010747)	2.70955669
19	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64994708
20	Mitochondrial inheritance (HP:0001427)	2.64759381
21	Stomatitis (HP:0010280)	2.62774561
22	Abnormality of the anterior horn cell (HP:0006802)	2.61947938
23	Degeneration of anterior horn cells (HP:0002398)	2.61947938
24	Increased muscle lipid content (HP:0009058)	2.58685953
25	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.58267148
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58229471
27	Septo-optic dysplasia (HP:0100842)	2.57891259
28	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.55608632
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.55608632
30	Lipid accumulation in hepatocytes (HP:0006561)	2.54213906
31	Hyperventilation (HP:0002883)	2.53435100
32	Hepatocellular necrosis (HP:0001404)	2.51289668
33	Progressive macrocephaly (HP:0004481)	2.50178179
34	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.48602916
35	Facial diplegia (HP:0001349)	2.47604338
36	Gait imbalance (HP:0002141)	2.43965676
37	Abnormal spermatogenesis (HP:0008669)	2.43535820
38	Microvesicular hepatic steatosis (HP:0001414)	2.39964390
39	Increased serum lactate (HP:0002151)	2.38157296
40	Increased CSF lactate (HP:0002490)	2.36022950
41	Spastic paraparesis (HP:0002313)	2.32653191
42	Acute encephalopathy (HP:0006846)	2.31929151
43	Cutaneous melanoma (HP:0012056)	2.28046634
44	Dyschromatopsia (HP:0007641)	2.26446387
45	Homocystinuria (HP:0002156)	2.24946597
46	Abnormality of homocysteine metabolism (HP:0010919)	2.24946597
47	Acute necrotizing encephalopathy (HP:0006965)	2.24753371
48	Agitation (HP:0000713)	2.23554758
49	Thyroiditis (HP:0100646)	2.23236794
50	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.23087180
51	Azoospermia (HP:0000027)	2.22170114
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.16373457
53	Hypoplasia of the fovea (HP:0007750)	2.16373457
54	Congenital primary aphakia (HP:0007707)	2.15747072
55	Lactic acidosis (HP:0003128)	2.13950777
56	Fibular aplasia (HP:0002990)	2.13332794
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.12769090
58	Abnormality of vitamin B metabolism (HP:0004340)	2.12461550
59	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.12274037
60	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.10646219
61	Akinesia (HP:0002304)	2.07185777
62	Congenital, generalized hypertrichosis (HP:0004540)	2.05434527
63	Congenital stationary night blindness (HP:0007642)	2.04948435
64	Constricted visual fields (HP:0001133)	2.04432791
65	Pendular nystagmus (HP:0012043)	2.04024577
66	Megaloblastic anemia (HP:0001889)	2.03041291
67	Prominent metopic ridge (HP:0005487)	2.00649477
68	Aplastic anemia (HP:0001915)	2.00295962
69	True hermaphroditism (HP:0010459)	1.99373114
70	Hepatic necrosis (HP:0002605)	1.99283595
71	Renal Fanconi syndrome (HP:0001994)	1.98809674
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97219802
73	Progressive microcephaly (HP:0000253)	1.96816328
74	Oral leukoplakia (HP:0002745)	1.95967611
75	Abnormality of T cell physiology (HP:0011840)	1.92930180
76	Spontaneous abortion (HP:0005268)	1.91087347
77	Hypokalemic alkalosis (HP:0001949)	1.90641458
78	Gonadotropin excess (HP:0000837)	1.90363028
79	Abnormality of the fovea (HP:0000493)	1.89298394
80	Limb dystonia (HP:0002451)	1.87890336
81	Morphological abnormality of the pyramidal tract (HP:0002062)	1.87268111
82	Nephrogenic diabetes insipidus (HP:0009806)	1.84367378
83	Hyperglycemia (HP:0003074)	1.84290676
84	IgG deficiency (HP:0004315)	1.84055943
85	Abnormality of the septum pellucidum (HP:0007375)	1.83558760
86	Poor head control (HP:0002421)	1.82817985
87	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.81480709
88	Neoplasm of the adrenal cortex (HP:0100641)	1.81211664
89	Fatigue (HP:0012378)	1.80606539
90	Abnormality of midbrain morphology (HP:0002418)	1.78443235
91	Molar tooth sign on MRI (HP:0002419)	1.78443235
92	Abnormality of the prostate (HP:0008775)	1.77857185
93	Panhypogammaglobulinemia (HP:0003139)	1.77747884
94	Parakeratosis (HP:0001036)	1.77446873
95	Methylmalonic acidemia (HP:0002912)	1.77072944
96	Abnormality of the metopic suture (HP:0005556)	1.76046138
97	Limb-girdle muscle atrophy (HP:0003797)	1.73823087
98	Bifid tongue (HP:0010297)	1.73781928
99	Sensory axonal neuropathy (HP:0003390)	1.70047823
100	Broad-based gait (HP:0002136)	1.69855545

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	6.97109197
2	WNK3	4.39360664
3	FRK	3.80731313
4	TSSK6	3.42053830
5	MST4	2.59027063
6	SRPK1	2.46308420
7	TAOK3	2.37879693
8	STK38L	2.19067055
9	MAP3K9	1.97405463
10	ZAK	1.89289224
11	CCNB1	1.86427683
12	DAPK2	1.81777565
13	NME1	1.73490940
14	VRK2	1.72821836
15	PHKG2	1.59470091
16	PHKG1	1.59470091
17	ERBB3	1.50136428
18	BCR	1.46013478
19	TLK1	1.39910630
20	DAPK1	1.36269528
21	PLK3	1.35362322
22	STK16	1.33009958
23	TEC	1.30765567
24	MYLK	1.21128188
25	CSNK1G3	1.19518708
26	MAP2K6	1.16411336
27	CSNK1G1	1.14162412
28	CSNK1A1L	1.13640397
29	NUAK1	1.07710555
30	GRK1	1.07455862
31	MARK1	1.02321230
32	ADRBK2	1.02184814
33	TXK	1.01280781
34	MAP3K12	1.00862895
35	PIK3CG	1.00834996
36	BMPR1B	1.00094244
37	MAP3K2	0.98357856
38	ITK	0.96938522
39	EIF2AK1	0.94779371
40	VRK1	0.92148493
41	CSNK1G2	0.91593548
42	NEK1	0.91584637
43	MAPK13	0.89373589
44	EIF2AK2	0.87040047
45	IRAK1	0.85124420
46	JAK1	0.79613825
47	CAMKK2	0.78038854
48	MINK1	0.77446461
49	FLT3	0.76472505
50	PAK3	0.76429662
51	TTK	0.70856038
52	DAPK3	0.69563158
53	PRKCG	0.66613366
54	MAP2K7	0.60912225
55	MAP3K4	0.58137924
56	BLK	0.57617044
57	PBK	0.57078311
58	BRSK2	0.55714176
59	GRK5	0.54966475
60	CLK1	0.54660925
61	FER	0.52959111
62	ATR	0.51761368
63	JAK3	0.49616503
64	SCYL2	0.47620720
65	KSR1	0.47556542
66	PRKCE	0.46840585
67	IRAK2	0.46645170
68	CASK	0.46283901
69	NTRK3	0.44938569
70	TBK1	0.43406289
71	CSNK2A1	0.43348734
72	BUB1	0.43185566
73	FGFR2	0.42943885
74	IKBKB	0.42800269
75	PRKCI	0.42758343
76	PLK1	0.42388209
77	DYRK2	0.40388450
78	STK38	0.39435694
79	LYN	0.38063594
80	PKN2	0.37112721
81	RPS6KA5	0.36893420
82	STK3	0.36388744
83	MKNK1	0.35801532
84	EGFR	0.34473340
85	EIF2AK3	0.34371018
86	CSNK2A2	0.34252616
87	AURKB	0.33543530
88	KIT	0.33257663
89	ABL2	0.32616052
90	PKN1	0.32513391
91	CDK19	0.32447861
92	CSNK1D	0.32138103
93	FES	0.31600319
94	ILK	0.30720148
95	IGF1R	0.30049302
96	ATM	0.29926304
97	JAK2	0.29518932
98	MAP4K1	0.29448609
99	BTK	0.29133546
100	MARK3	0.28576958

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.54193237
2	Sulfur metabolism_Homo sapiens_hsa00920	3.42882565
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.31951468
4	Protein export_Homo sapiens_hsa03060	3.09875282
5	Asthma_Homo sapiens_hsa05310	2.81584644
6	Homologous recombination_Homo sapiens_hsa03440	2.78166715
7	Parkinsons disease_Homo sapiens_hsa05012	2.54939255
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.38939083
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.35028153
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.28704938
11	Mismatch repair_Homo sapiens_hsa03430	2.24432838
12	Allograft rejection_Homo sapiens_hsa05330	2.24122436
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22802888
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.20459327
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.16555456
16	RNA polymerase_Homo sapiens_hsa03020	2.05097767
17	Non-homologous end-joining_Homo sapiens_hsa03450	2.01124040
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.98489218
19	Regulation of autophagy_Homo sapiens_hsa04140	1.95063568
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87502553
21	RNA transport_Homo sapiens_hsa03013	1.73202755
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.70992242
23	Basal transcription factors_Homo sapiens_hsa03022	1.61500935
24	Alzheimers disease_Homo sapiens_hsa05010	1.49759290
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.48717432
26	Propanoate metabolism_Homo sapiens_hsa00640	1.45949806
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.43870566
28	Phototransduction_Homo sapiens_hsa04744	1.36653563
29	Huntingtons disease_Homo sapiens_hsa05016	1.36017196
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.33533090
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.31781904
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.30392010
33	Ribosome_Homo sapiens_hsa03010	1.16266101
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.13807019
35	Peroxisome_Homo sapiens_hsa04146	1.09438640
36	Leishmaniasis_Homo sapiens_hsa05140	1.06897744
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05493387
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00466932
39	DNA replication_Homo sapiens_hsa03030	0.98423637
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96877739
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96190860
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92821131
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.89989870
44	Spliceosome_Homo sapiens_hsa03040	0.89833198
45	Olfactory transduction_Homo sapiens_hsa04740	0.87525647
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87334898
47	Purine metabolism_Homo sapiens_hsa00230	0.87296967
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.80963118
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80234769
50	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.79022100
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78788544
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.78726357
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.76528905
54	Glutathione metabolism_Homo sapiens_hsa00480	0.75212465
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73361591
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71814813
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71760281
58	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.71171672
59	Herpes simplex infection_Homo sapiens_hsa05168	0.69873187
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67678794
61	Viral myocarditis_Homo sapiens_hsa05416	0.67650657
62	RNA degradation_Homo sapiens_hsa03018	0.65533308
63	Taste transduction_Homo sapiens_hsa04742	0.65273868
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62696567
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62471639
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60454168
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57539867
68	Serotonergic synapse_Homo sapiens_hsa04726	0.56720810
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55396064
70	Salmonella infection_Homo sapiens_hsa05132	0.54778025
71	Folate biosynthesis_Homo sapiens_hsa00790	0.52898928
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52627725
73	Toxoplasmosis_Homo sapiens_hsa05145	0.51499359
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.51481734
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51077525
76	Oocyte meiosis_Homo sapiens_hsa04114	0.50710348
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48613183
78	Primary immunodeficiency_Homo sapiens_hsa05340	0.46884095
79	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46289384
80	Sulfur relay system_Homo sapiens_hsa04122	0.45912425
81	Cell cycle_Homo sapiens_hsa04110	0.44681414
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44180208
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44044361
84	Phagosome_Homo sapiens_hsa04145	0.42460089
85	Metabolic pathways_Homo sapiens_hsa01100	0.42405244
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40012933
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37734771
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34774231
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34696826
90	Renin secretion_Homo sapiens_hsa04924	0.33798364
91	Tuberculosis_Homo sapiens_hsa05152	0.32368786
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31490392
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30648986
94	Measles_Homo sapiens_hsa05162	0.30104132
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29777926
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25675698
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.23931775
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22107057
99	Circadian rhythm_Homo sapiens_hsa04710	0.21864360
100	Morphine addiction_Homo sapiens_hsa05032	0.21558593

EIF4BP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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