EIF4E1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)9.29799156
2piRNA metabolic process (GO:0034587)9.25561474
3regulation of DNA methylation (GO:0044030)8.29456785
4regulation of female gonad development (GO:2000194)7.22109850
5protein kinase C signaling (GO:0070528)7.22056150
6retinal cone cell development (GO:0046549)6.63506602
7protein K6-linked ubiquitination (GO:0085020)6.63294152
8positive regulation of humoral immune response (GO:0002922)6.14636046
9mitotic chromosome condensation (GO:0007076)6.03232671
10female gamete generation (GO:0007292)5.99262179
11regulation of meiosis (GO:0040020)5.86487105
12regulation of exit from mitosis (GO:0007096)5.73482124
13DNA methylation involved in gamete generation (GO:0043046)5.68507794
14histone H2A monoubiquitination (GO:0035518)5.55597663
15reproduction (GO:0000003)5.52042052
16regulation of calcium ion-dependent exocytosis (GO:0017158)5.49732981
17positive regulation of histone H3-K4 methylation (GO:0051571)5.30856426
18negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.27446459
19DNA damage induced protein phosphorylation (GO:0006975)5.22526546
20mitotic metaphase plate congression (GO:0007080)5.21914268
21citrulline biosynthetic process (GO:0019240)5.14700397
22regulation of acrosome reaction (GO:0060046)5.13607697
23regulation of histone H3-K9 methylation (GO:0051570)5.09224664
24glycine transport (GO:0015816)5.05037917
25histone H2A ubiquitination (GO:0033522)4.89254969
26meiotic chromosome segregation (GO:0045132)4.86752259
27regulation of steroid hormone secretion (GO:2000831)4.86050704
28notochord development (GO:0030903)4.82137956
29regulation of steroid hormone biosynthetic process (GO:0090030)4.81645282
30negative regulation of meiosis (GO:0045835)4.77064951
31regulation of sister chromatid cohesion (GO:0007063)4.73840738
32female gonad development (GO:0008585)4.71147227
33meiotic cell cycle (GO:0051321)4.69853679
34regulation of meiotic cell cycle (GO:0051445)4.62301948
35oocyte maturation (GO:0001556)4.62265356
36male meiosis (GO:0007140)4.59656110
37regulation of meiosis I (GO:0060631)4.56217232
38negative regulation of smooth muscle cell differentiation (GO:0051151)4.55263648
39base-excision repair, AP site formation (GO:0006285)4.46601264
40mitotic sister chromatid segregation (GO:0000070)4.44738042
41DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.43746797
42establishment of chromosome localization (GO:0051303)4.39977582
43binding of sperm to zona pellucida (GO:0007339)4.39608333
44negative regulation of histone methylation (GO:0031061)4.37931194
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.36930963
46positive regulation of mitotic sister chromatid separation (GO:1901970)4.36930963
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.36930963
48metaphase plate congression (GO:0051310)4.36695707
49DNA damage response, signal transduction resulting in transcription (GO:0042772)4.32333295
50L-amino acid import (GO:0043092)4.29726248
51mitotic sister chromatid cohesion (GO:0007064)4.15373544
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.15270747
53microtubule severing (GO:0051013)4.14564456
54regulation of phospholipid biosynthetic process (GO:0071071)4.11668957
55multicellular organism reproduction (GO:0032504)4.10409602
56DNA alkylation (GO:0006305)4.09531038
57DNA methylation (GO:0006306)4.09531038
58regulation of cell maturation (GO:1903429)4.08759553
59gene silencing by RNA (GO:0031047)4.06574230
60positive regulation of reproductive process (GO:2000243)4.04317729
61regulation of retinoic acid receptor signaling pathway (GO:0048385)4.02384426
62regulation of histone H3-K27 methylation (GO:0061085)4.01796729
63negative regulation of reproductive process (GO:2000242)3.98617330
64single fertilization (GO:0007338)3.94844713
65attachment of spindle microtubules to kinetochore (GO:0008608)3.94495929
66phosphorelay signal transduction system (GO:0000160)3.87552841
67positive regulation of meiosis (GO:0045836)3.84653483
68positive regulation of gastrulation (GO:2000543)3.78906084
69ovulation cycle (GO:0042698)3.78520331
70glycerophospholipid catabolic process (GO:0046475)3.71370287
71sister chromatid cohesion (GO:0007062)3.71058013
72kinetochore assembly (GO:0051382)3.69090445
73sphingosine metabolic process (GO:0006670)3.63800055
74chromosome segregation (GO:0007059)3.63701321
75regulation of reproductive process (GO:2000241)3.61704402
76regulation of hypersensitivity (GO:0002883)3.60528406
77positive regulation of meiotic cell cycle (GO:0051446)3.55884623
78positive regulation of chromosome segregation (GO:0051984)3.55763079
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53571165
80positive regulation of histone methylation (GO:0031062)3.51340896
81sister chromatid segregation (GO:0000819)3.48839505
82type B pancreatic cell development (GO:0003323)3.47364838
83sperm-egg recognition (GO:0035036)3.45799930
84positive regulation of megakaryocyte differentiation (GO:0045654)3.44958128
85regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.43083409
86oogenesis (GO:0048477)3.40463712
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.39105930
88pyrimidine nucleotide catabolic process (GO:0006244)3.37862258
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.37048809
90protein localization to chromosome, centromeric region (GO:0071459)3.35531506
91negative regulation of circadian rhythm (GO:0042754)3.34544644
92synaptic vesicle docking involved in exocytosis (GO:0016081)3.33835394
93primitive streak formation (GO:0090009)3.33010211
94diol metabolic process (GO:0034311)3.29665069
95positive regulation of exocytosis (GO:0045921)3.29600207
96regulation of keratinocyte proliferation (GO:0010837)3.28928696
97monoubiquitinated protein deubiquitination (GO:0035520)3.28543093
98chemosensory behavior (GO:0007635)3.27774081
99negative regulation of keratinocyte proliferation (GO:0010839)3.27042717
100kinetochore organization (GO:0051383)3.23837708
101negative regulation of hormone metabolic process (GO:0032351)3.23563939
102negative regulation of hormone biosynthetic process (GO:0032353)3.23563939
103phosphatidylinositol dephosphorylation (GO:0046856)3.22649781
104positive regulation of DNA-dependent DNA replication (GO:2000105)3.22416420
105maturation of 5.8S rRNA (GO:0000460)3.21200537
106N-terminal protein amino acid acetylation (GO:0006474)3.20466982
107relaxation of smooth muscle (GO:0044557)3.19425831
108positive regulation of hormone biosynthetic process (GO:0046886)3.19258620
109amino acid import (GO:0043090)3.16977418
110regulation of histone H3-K4 methylation (GO:0051569)3.16337800
111regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14263413
112paraxial mesoderm development (GO:0048339)3.12885403
113oocyte development (GO:0048599)3.11169056
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09199692
115negative regulation of DNA-templated transcription, elongation (GO:0032785)3.09199692
116snRNA transcription (GO:0009301)3.08973593
117cartilage morphogenesis (GO:0060536)3.08705122
118regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.08296721
119regulation of female receptivity (GO:0045924)3.06039495
120phospholipid dephosphorylation (GO:0046839)3.05762351
121synaptic vesicle maturation (GO:0016188)3.03899363
122protein localization to chromosome (GO:0034502)3.03116189
123CENP-A containing nucleosome assembly (GO:0034080)3.01894309
124protein K11-linked ubiquitination (GO:0070979)3.01867294
125DNA methylation or demethylation (GO:0044728)3.00577187
126regulation of spindle organization (GO:0090224)2.99930869
127myoblast migration (GO:0051451)2.99525407
128cellular response to gamma radiation (GO:0071480)2.98701127
129DNA modification (GO:0006304)2.98413687
130phosphatidylglycerol biosynthetic process (GO:0006655)2.98013715
131calcium ion-dependent exocytosis (GO:0017156)2.97637197
132peptidyl-arginine modification (GO:0018195)2.96879551
133DNA replication-independent nucleosome assembly (GO:0006336)2.96300517
134DNA replication-independent nucleosome organization (GO:0034724)2.96300517
135centriole replication (GO:0007099)2.96001885
136fertilization (GO:0009566)2.95906835
137microtubule nucleation (GO:0007020)2.95736097
138synaptonemal complex assembly (GO:0007130)2.95167177
139regulation of histone methylation (GO:0031060)2.93878253
140positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.92423226
141protein monoubiquitination (GO:0006513)2.91177686
142synapsis (GO:0007129)2.89367893
143chromatin remodeling at centromere (GO:0031055)2.89238151
144regulation of corticosteroid hormone secretion (GO:2000846)2.88928068
145regulation of RIG-I signaling pathway (GO:0039535)2.87535849
146negative regulation of meiotic cell cycle (GO:0051447)2.86615566
147interkinetic nuclear migration (GO:0022027)2.85710858
148neuron fate determination (GO:0048664)2.84939395
149protein localization to kinetochore (GO:0034501)2.83746312
150meiotic nuclear division (GO:0007126)2.83580548
151male meiosis I (GO:0007141)2.82866193
152regulation of hormone biosynthetic process (GO:0046885)2.81028497
153negative regulation of cAMP-mediated signaling (GO:0043951)2.80371074
154positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80072578
155negative regulation of histone modification (GO:0031057)2.79894817
156cochlea development (GO:0090102)2.78982884
157glandular epithelial cell development (GO:0002068)2.78310957
158somite rostral/caudal axis specification (GO:0032525)2.77125103
159cell-cell recognition (GO:0009988)2.76417919
160regulation of chromatin silencing (GO:0031935)2.75486762
161regulation of exocytosis (GO:0017157)2.69512666
162gene silencing (GO:0016458)2.66659635
163dopamine biosynthetic process (GO:0042416)2.65239887
164sleep (GO:0030431)2.61548259
165citrulline metabolic process (GO:0000052)2.55601783
166aggressive behavior (GO:0002118)2.54554877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.22940461
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.71576952
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81725657
4E2F7_22180533_ChIP-Seq_HELA_Human3.68727789
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51728059
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.26599862
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.14783162
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.99461893
9KAP1_22055183_ChIP-Seq_ESCs_Mouse2.86716643
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.80801104
11IGF1R_20145208_ChIP-Seq_DFB_Human2.66135929
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.65477054
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34525591
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33720291
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.25625528
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.24090651
17AR_21909140_ChIP-Seq_LNCAP_Human2.23698205
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08661655
19RNF2_27304074_Chip-Seq_NSC_Mouse2.07386423
20REST_21632747_ChIP-Seq_MESCs_Mouse2.01679601
21SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00171618
22EZH2_22144423_ChIP-Seq_EOC_Human14.1828750
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89584148
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.88585028
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88389479
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88389479
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88389479
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81174244
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.79002673
30LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76801348
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.72874173
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71432742
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71396230
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.70004362
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69789258
36MYC_18940864_ChIP-ChIP_HL60_Human1.65754483
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65474820
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65204520
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.63081222
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60198074
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.59853343
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59261956
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56758565
44DROSHA_22980978_ChIP-Seq_HELA_Human1.53472355
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.52868660
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.51706515
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50597417
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45186427
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.43529352
50OCT4_18555785_Chip-Seq_ESCs_Mouse1.42965596
51SMAD4_21799915_ChIP-Seq_A2780_Human1.40819853
52TCF4_23295773_ChIP-Seq_U87_Human1.40536176
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.39049468
54STAT3_23295773_ChIP-Seq_U87_Human1.38806294
55NMYC_18555785_Chip-Seq_ESCs_Mouse1.38189977
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37997465
57CTCF_18555785_Chip-Seq_ESCs_Mouse1.37816083
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.37660710
59ESRRB_18555785_Chip-Seq_ESCs_Mouse1.37545432
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36428111
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36428111
62NFYA_21822215_ChIP-Seq_K562_Human1.36403680
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.35993518
64AR_25329375_ChIP-Seq_VCAP_Human1.35264649
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32955403
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31513217
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31309629
68EWS_26573619_Chip-Seq_HEK293_Human1.31271877
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.31122998
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.30642627
71P53_22387025_ChIP-Seq_ESCs_Mouse1.29145412
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28870015
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28829471
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.27540420
75STAT1_17558387_ChIP-Seq_HELA_Human1.27321380
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27248090
77KLF4_18555785_Chip-Seq_ESCs_Mouse1.27172082
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.27003244
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26667078
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.26546597
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25976729
82TBL1_22424771_ChIP-Seq_293T_Human1.24773342
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24505863
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.23966671
85P300_18555785_Chip-Seq_ESCs_Mouse1.23692134
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.22886673
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22418333
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21824035
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21172524
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20851965
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.20388820
92FUS_26573619_Chip-Seq_HEK293_Human1.19879913
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18884717
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18274677
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18151605
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18142710
97ETV1_20927104_ChIP-Seq_GIST48_Human1.17663848
98CDX2_22108803_ChIP-Seq_LS180_Human1.16758105
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16175140
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16140776
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15896533
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15116982
103RUNX2_22187159_ChIP-Seq_PCA_Human1.15048202
104GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14978930
105HNFA_21074721_ChIP-Seq_CACO-2_Human1.13970498
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11310117
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10009890
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09466496
109AR_21572438_ChIP-Seq_LNCaP_Human1.08985018
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07294875
111CBP_20019798_ChIP-Seq_JUKART_Human1.07166821
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07166821
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06490674
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05682301
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.04916063
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04088149
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02841427
118GATA6_21074721_ChIP-Seq_CACO-2_Human1.02301307
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01841717
120RBPJ_21746931_ChIP-Seq_IB4_Human1.01643333
121PHF8_20622853_ChIP-Seq_HELA_Human1.01499597
122CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01348518
123GF1B_26923725_Chip-Seq_HPCs_Mouse1.01070287
124KDM2B_26808549_Chip-Seq_REH_Human1.01051568
125HTT_18923047_ChIP-ChIP_STHdh_Human1.00920567
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99959870
127GBX2_23144817_ChIP-Seq_PC3_Human0.99646515
128GATA3_21867929_ChIP-Seq_TH1_Mouse0.99327294
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99247211
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98608568
131AHR_22903824_ChIP-Seq_MCF-7_Human0.97759834
132P300_19829295_ChIP-Seq_ESCs_Human0.97625501
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97410910
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.97360837
135ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97355556
136CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97220411
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.97017910
138NFYB_21822215_ChIP-Seq_K562_Human0.96747960
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95239176
140RXR_22108803_ChIP-Seq_LS180_Human0.94626279
141GF1_26923725_Chip-Seq_HPCs_Mouse0.94292708
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92939307
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92931025
144PU1_27457419_Chip-Seq_LIVER_Mouse0.92873761
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91982309
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.91664678
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90340857
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89699084
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87146033
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86406758
151GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86171668
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85286173
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85115934
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.85063843
155TCF4_22108803_ChIP-Seq_LS180_Human0.84196849
156JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84123843
157CBP_21632823_ChIP-Seq_H3396_Human0.83869090
158SMRT_27268052_Chip-Seq_Bcells_Human0.83804228
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83622030
160AR_19668381_ChIP-Seq_PC3_Human0.82473823
161TAL1_26923725_Chip-Seq_HPCs_Mouse0.81396077
162RARB_27405468_Chip-Seq_BRAIN_Mouse0.80443158
163TP53_22573176_ChIP-Seq_HFKS_Human0.79895680
164TAF15_26573619_Chip-Seq_HEK293_Human0.78072084
165NANOG_20526341_ChIP-Seq_ESCs_Human0.78007161
166KLF4_19829295_ChIP-Seq_ESCs_Human0.76534421
167FOXH1_21741376_ChIP-Seq_EPCs_Human0.75976598
168EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73907599
169TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73893691
170TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.73677532
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73638812
172SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.73138956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.20656447
2MP0003718_maternal_effect6.15222612
3MP0005451_abnormal_body_composition4.40113556
4MP0008877_abnormal_DNA_methylation3.77073352
5MP0003693_abnormal_embryo_hatching3.35531739
6MP0003787_abnormal_imprinting3.28996222
7MP0002653_abnormal_ependyma_morphology3.27894581
8MP0006292_abnormal_olfactory_placode3.27731192
9MP0010234_abnormal_vibrissa_follicle3.11677604
10MP0004859_abnormal_synaptic_plasticity2.86023729
11MP0008789_abnormal_olfactory_epithelium2.83403309
12MP0005499_abnormal_olfactory_system2.81660734
13MP0005394_taste/olfaction_phenotype2.81660734
14MP0002102_abnormal_ear_morphology2.80474650
15MP0003879_abnormal_hair_cell2.78331466
16MP0003699_abnormal_female_reproductive2.65897796
17MP0003077_abnormal_cell_cycle2.65271960
18MP0005646_abnormal_pituitary_gland2.62800546
19MP0003111_abnormal_nucleus_morphology2.59795245
20MP0005395_other_phenotype2.58836187
21MP0001119_abnormal_female_reproductive2.57248075
22MP0010094_abnormal_chromosome_stability2.56117935
23MP0003315_abnormal_perineum_morphology2.37373194
24MP0005257_abnormal_intraocular_pressure2.27773449
25MP0004270_analgesia2.25825967
26MP0002272_abnormal_nervous_system2.18299371
27MP0004957_abnormal_blastocyst_morpholog2.17915100
28MP0001929_abnormal_gametogenesis2.16034663
29MP0003880_abnormal_central_pattern2.10753241
30MP0003121_genomic_imprinting2.08216473
31MP0000579_abnormal_nail_morphology2.08085837
32MP0002249_abnormal_larynx_morphology2.07770047
33MP0002210_abnormal_sex_determination2.07466070
34MP0003937_abnormal_limbs/digits/tail_de2.03313069
35MP0003195_calcinosis1.99026898
36MP0005408_hypopigmentation1.98621263
37MP0000653_abnormal_sex_gland1.96896748
38MP0000566_synostosis1.96469465
39MP0002138_abnormal_hepatobiliary_system1.92029782
40MP0003635_abnormal_synaptic_transmissio1.88512801
41MP0002139_abnormal_hepatobiliary_system1.76925488
42MP0009745_abnormal_behavioral_response1.76625088
43MP0009780_abnormal_chondrocyte_physiolo1.74111343
44MP0005310_abnormal_salivary_gland1.68339272
45MP0001984_abnormal_olfaction1.67198410
46MP0002163_abnormal_gland_morphology1.63085247
47MP0001346_abnormal_lacrimal_gland1.62434455
48MP0004185_abnormal_adipocyte_glucose1.57902439
49MP0003183_abnormal_peptide_metabolism1.48117655
50MP0002064_seizures1.47689361
51MP0009046_muscle_twitch1.46979035
52MP0005410_abnormal_fertilization1.45934839
53MP0002234_abnormal_pharynx_morphology1.45324967
54MP0002734_abnormal_mechanical_nocicepti1.44768383
55MP0001145_abnormal_male_reproductive1.38717059
56MP0002572_abnormal_emotion/affect_behav1.37726853
57MP0002063_abnormal_learning/memory/cond1.37668590
58MP0010030_abnormal_orbit_morphology1.37622682
59MP0008932_abnormal_embryonic_tissue1.37564618
60MP0000613_abnormal_salivary_gland1.36465443
61MP0005551_abnormal_eye_electrophysiolog1.35006840
62MP0003136_yellow_coat_color1.34383086
63MP0002877_abnormal_melanocyte_morpholog1.34295560
64MP0009697_abnormal_copulation1.33639608
65MP0005187_abnormal_penis_morphology1.30802974
66MP0002161_abnormal_fertility/fecundity1.30644332
67MP0008260_abnormal_autophagy1.28008851
68MP0003890_abnormal_embryonic-extraembry1.27532721
69MP0001529_abnormal_vocalization1.25881512
70MP0000569_abnormal_digit_pigmentation1.23152459
71MP0000639_abnormal_adrenal_gland1.20735155
72MP0002085_abnormal_embryonic_tissue1.20577895
73MP0002160_abnormal_reproductive_system1.20162804
74MP0001486_abnormal_startle_reflex1.19576014
75MP0000350_abnormal_cell_proliferation1.17479251
76MP0004142_abnormal_muscle_tone1.16324420
77MP0005379_endocrine/exocrine_gland_phen1.13953053
78MP0006276_abnormal_autonomic_nervous1.12886825
79MP0010307_abnormal_tumor_latency1.10013006
80MP0003123_paternal_imprinting1.09505383
81MP0002229_neurodegeneration1.08768727
82MP0004264_abnormal_extraembryonic_tissu1.08257809
83MP0002090_abnormal_vision1.06792555
84MP0005423_abnormal_somatic_nervous1.06006895
85MP0001730_embryonic_growth_arrest1.04779425
86MP0001944_abnormal_pancreas_morphology1.04175337
87MP0003755_abnormal_palate_morphology1.02709637
88MP0008058_abnormal_DNA_repair1.00466531
89MP0010678_abnormal_skin_adnexa1.00126733
90MP0002638_abnormal_pupillary_reflex0.99107055
91MP0002067_abnormal_sensory_capabilities0.99070745
92MP0008007_abnormal_cellular_replicative0.98722421
93MP0000490_abnormal_crypts_of0.98154287
94MP0001963_abnormal_hearing_physiology0.97238028
95MP0009250_abnormal_appendicular_skeleto0.96418561
96MP0005380_embryogenesis_phenotype0.95050811
97MP0001672_abnormal_embryogenesis/_devel0.95050811
98MP0003763_abnormal_thymus_physiology0.94262123
99MP0001968_abnormal_touch/_nociception0.92408710
100MP0003122_maternal_imprinting0.92286911
101MP0008057_abnormal_DNA_replication0.89530185
102MP0002735_abnormal_chemical_nociception0.89414763
103MP0003252_abnormal_bile_duct0.88134596
104MP0005360_urolithiasis0.87514978
105MP0001502_abnormal_circadian_rhythm0.87389266
106MP0003329_amyloid_beta_deposits0.86211373
107MP0002084_abnormal_developmental_patter0.86075655
108MP0002557_abnormal_social/conspecific_i0.85954739
109MP0005174_abnormal_tail_pigmentation0.85556688
110MP0001501_abnormal_sleep_pattern0.85231021
111MP0002233_abnormal_nose_morphology0.85176493
112MP0010368_abnormal_lymphatic_system0.85055640
113MP0004924_abnormal_behavior0.84504003
114MP0005386_behavior/neurological_phenoty0.84504003
115MP0001664_abnormal_digestion0.84338872
116MP0001697_abnormal_embryo_size0.83113771
117MP0001919_abnormal_reproductive_system0.82739858
118MP0002928_abnormal_bile_duct0.82016795
119MP0002909_abnormal_adrenal_gland0.80985051
120MP0004811_abnormal_neuron_physiology0.80593375
121MP0010386_abnormal_urinary_bladder0.80310278
122MP0002019_abnormal_tumor_incidence0.80250923
123MP0009840_abnormal_foam_cell0.80235948
124MP0000462_abnormal_digestive_system0.79846042
125MP0003950_abnormal_plasma_membrane0.76746347
126MP0000631_abnormal_neuroendocrine_gland0.76543764
127MP0002116_abnormal_craniofacial_bone0.75757226
128MP0000678_abnormal_parathyroid_gland0.74788256
129MP0002109_abnormal_limb_morphology0.74692410
130MP0003119_abnormal_digestive_system0.74680897
131MP0005647_abnormal_sex_gland0.74090970
132MP0003698_abnormal_male_reproductive0.74043833
133MP0001666_abnormal_nutrient_absorption0.72698183
134MP0000432_abnormal_head_morphology0.69657064
135MP0003868_abnormal_feces_composition0.69491745
136MP0001905_abnormal_dopamine_level0.69417213
137MP0001915_intracranial_hemorrhage0.69334597
138MP0005389_reproductive_system_phenotype0.68974877
139MP0002066_abnormal_motor_capabilities/c0.68588394
140MP0003935_abnormal_craniofacial_develop0.68406029
141MP0005645_abnormal_hypothalamus_physiol0.68342150
142MP0009384_cardiac_valve_regurgitation0.68229476
143MP0002282_abnormal_trachea_morphology0.67371419
144MP0003633_abnormal_nervous_system0.65523776
145MP0000015_abnormal_ear_pigmentation0.64443649
146MP0002882_abnormal_neuron_morphology0.63641033
147MP0002332_abnormal_exercise_endurance0.63423553
148MP0006072_abnormal_retinal_apoptosis0.61716276
149MP0008995_early_reproductive_senescence0.61460994
150MP0001986_abnormal_taste_sensitivity0.61144141
151MP0003861_abnormal_nervous_system0.60935964
152MP0002177_abnormal_outer_ear0.57668324
153MP0003938_abnormal_ear_development0.56835695
154MP0001851_eye_inflammation0.56115922
155MP0001286_abnormal_eye_development0.53083014
156MP0004510_myositis0.52593150
157MP0003984_embryonic_growth_retardation0.50102048
158MP0005621_abnormal_cell_physiology0.49146283
159MP0000427_abnormal_hair_cycle0.45186201
160MP0002088_abnormal_embryonic_growth/wei0.44774137
161MP0004782_abnormal_surfactant_physiolog0.44613255
162MP0002127_abnormal_cardiovascular_syste0.43365030
163MP0001849_ear_inflammation0.42642954
164MP0000313_abnormal_cell_death0.42207735

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.96890736
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.88984298
3Male infertility (HP:0003251)5.72137183
4Papillary thyroid carcinoma (HP:0002895)5.10751886
5Myokymia (HP:0002411)4.49831110
6Abnormality of the fovea (HP:0000493)4.46070207
7Adrenal hypoplasia (HP:0000835)4.40013724
8Flat capital femoral epiphysis (HP:0003370)4.27200923
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.20085611
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.10770729
11Hypoplasia of the fovea (HP:0007750)4.10770729
12Cortical dysplasia (HP:0002539)4.05946419
13Hypoglycemic coma (HP:0001325)4.01094108
14Apathy (HP:0000741)3.80726661
15Increased circulating renin level (HP:0000848)3.76764409
16Hypoglycemic seizures (HP:0002173)3.74974090
17Lip pit (HP:0100267)3.70853713
18Abdominal situs inversus (HP:0003363)3.70248216
19Abnormality of abdominal situs (HP:0011620)3.70248216
20Hypokinesia (HP:0002375)3.64195636
21Shawl scrotum (HP:0000049)3.62934982
22Abnormality of the fingertips (HP:0001211)3.57535353
23Birth length less than 3rd percentile (HP:0003561)3.57467768
24Diminished motivation (HP:0000745)3.53893054
25Patellar aplasia (HP:0006443)3.49301326
26Enlarged penis (HP:0000040)3.45579728
27Premature ovarian failure (HP:0008209)3.33806682
28Acute myeloid leukemia (HP:0004808)3.31363268
29Hypergonadotropic hypogonadism (HP:0000815)3.28656487
30Gaze-evoked nystagmus (HP:0000640)3.28518395
31Facial hemangioma (HP:0000329)3.27050565
32Aplasia/Hypoplasia of the patella (HP:0006498)3.22389704
33Breast aplasia (HP:0100783)3.22262730
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.21312721
35Insulin-resistant diabetes mellitus (HP:0000831)3.20669461
36Osteomalacia (HP:0002749)3.20267318
37Hyperinsulinemic hypoglycemia (HP:0000825)3.19401130
38Sensory axonal neuropathy (HP:0003390)3.19257935
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15602409
40Septo-optic dysplasia (HP:0100842)3.14038910
41Aplasia/Hypoplasia of the uvula (HP:0010293)3.10629065
42Capillary hemangiomas (HP:0005306)3.09122069
43Supranuclear gaze palsy (HP:0000605)3.07165217
44Cholecystitis (HP:0001082)3.05386511
45Abnormal gallbladder physiology (HP:0012438)3.05386511
46Hypophosphatemic rickets (HP:0004912)3.03725938
47Pulmonary fibrosis (HP:0002206)3.03025061
48Dysdiadochokinesis (HP:0002075)3.02583912
49Secondary amenorrhea (HP:0000869)2.99984718
50Infertility (HP:0000789)2.98435287
51Breast hypoplasia (HP:0003187)2.95913541
52Febrile seizures (HP:0002373)2.95258756
53Ectopic kidney (HP:0000086)2.94138594
54Abnormality of chromosome stability (HP:0003220)2.93674769
55Lower limb hyperreflexia (HP:0002395)2.91662216
56Primary amenorrhea (HP:0000786)2.90666773
57Truncal obesity (HP:0001956)2.89562477
58Abnormality of the labia minora (HP:0012880)2.88300277
59Meckel diverticulum (HP:0002245)2.85780578
60Abnormality of the preputium (HP:0100587)2.80692414
61Dysmetric saccades (HP:0000641)2.76728147
62Urethral obstruction (HP:0000796)2.75137286
63Prostate neoplasm (HP:0100787)2.72278280
64Malnutrition (HP:0004395)2.71205067
65Abnormality of the ileum (HP:0001549)2.68139628
66Clubbing of toes (HP:0100760)2.64108544
67Gonadotropin excess (HP:0000837)2.55929207
68Anosmia (HP:0000458)2.55447878
69Aplasia/Hypoplasia of the macula (HP:0008059)2.53500788
70Thyroid carcinoma (HP:0002890)2.53271803
71Impaired smooth pursuit (HP:0007772)2.53070639
72Hypercortisolism (HP:0001578)2.52526159
73Neurofibrillary tangles (HP:0002185)2.52199265
74Rib fusion (HP:0000902)2.51114662
75Absent septum pellucidum (HP:0001331)2.50495311
76Bundle branch block (HP:0011710)2.48563115
77Abnormality of chromosome segregation (HP:0002916)2.48284971
78Abnormality of midbrain morphology (HP:0002418)2.45938807
79Molar tooth sign on MRI (HP:0002419)2.45938807
80Abnormality of the phalanges of the hallux (HP:0010057)2.45190799
81Abnormal biliary tract physiology (HP:0012439)2.43689114
82Bile duct proliferation (HP:0001408)2.43689114
83Impulsivity (HP:0100710)2.43424770
84Symptomatic seizures (HP:0011145)2.43222744
85Abnormality of the pancreatic islet cells (HP:0006476)2.42675868
86Abnormality of endocrine pancreas physiology (HP:0012093)2.42675868
87Atelectasis (HP:0100750)2.41868529
88Midline defect of the nose (HP:0004122)2.41319543
89Truncal ataxia (HP:0002078)2.40117369
90Abnormality of the epiphysis of the femoral head (HP:0010574)2.38824575
91Median cleft lip (HP:0000161)2.36630330
92Nonprogressive disorder (HP:0003680)2.36408666
93Abnormality of the femoral head (HP:0003368)2.35160035
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34529450
95Anterior segment dysgenesis (HP:0007700)2.28757995
96Supernumerary spleens (HP:0009799)2.28189863
97Hyperglycemia (HP:0003074)2.28154813
98Azoospermia (HP:0000027)2.28142037
99Mutism (HP:0002300)2.27525985
100Fair hair (HP:0002286)2.24301507
101Epileptiform EEG discharges (HP:0011182)2.23675124
102Abnormality of calcium-phosphate metabolism (HP:0100530)2.23175896
103Hypogonadotrophic hypogonadism (HP:0000044)2.22843501
104Diminished movement (HP:0002374)2.21940334
105Abnormality of the intervertebral disk (HP:0005108)2.21845365
106Hypoplastic iliac wings (HP:0002866)2.21587587
107Abnormality of the carotid arteries (HP:0005344)2.18324403
108Abnormality of femoral epiphyses (HP:0006499)2.17756666
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.17756666
110Postural tremor (HP:0002174)2.16512757
111Bradykinesia (HP:0002067)2.15911744
112Methylmalonic acidemia (HP:0002912)2.12785835
113Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11915964
114EEG with generalized epileptiform discharges (HP:0011198)2.10642311
115Delayed puberty (HP:0000823)2.10605824
116Abnormality of lateral ventricle (HP:0030047)2.08485296
117Small intestinal stenosis (HP:0012848)2.08466511
118Duodenal stenosis (HP:0100867)2.08466511
119Sloping forehead (HP:0000340)2.07719023
120Intention tremor (HP:0002080)2.07482684
121Erectile abnormalities (HP:0100639)2.06635282
122Hypomagnesemia (HP:0002917)2.06415332
123Abnormality of ocular smooth pursuit (HP:0000617)2.05399714
124Posterior subcapsular cataract (HP:0007787)2.03576574
125Short thumb (HP:0009778)2.03365454
126Hypsarrhythmia (HP:0002521)2.02118728
127Ketoacidosis (HP:0001993)2.01463326
128Posterior embryotoxon (HP:0000627)2.01285056
129Anomalous pulmonary venous return (HP:0010772)2.01275574
130Maternal diabetes (HP:0009800)1.99382132
131Abnormality of the septum pellucidum (HP:0007375)1.98295319
132Pancreatic fibrosis (HP:0100732)1.97870479
133Oligodactyly (hands) (HP:0001180)1.96892621
134Myelodysplasia (HP:0002863)1.96823962
135Metaphyseal irregularity (HP:0003025)1.96595868
136Action tremor (HP:0002345)1.93247139
137Generalized hypopigmentation of hair (HP:0011358)1.92714707
138Depressed nasal tip (HP:0000437)1.92317667
139Focal seizures (HP:0007359)1.89748756
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.89746172
141Pancreatic cysts (HP:0001737)1.87459930
142Abnormality of magnesium homeostasis (HP:0004921)1.87328017
143Abnormality of the line of Schwalbe (HP:0008048)1.86807560
144Absent radius (HP:0003974)1.85613086
145Duplicated collecting system (HP:0000081)1.85458697
146Abnormality of the renal collecting system (HP:0004742)1.85036097
147Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.84627965
148Abnormal respiratory motile cilium physiology (HP:0012261)1.83903704
149Torticollis (HP:0000473)1.83325974
150Short tibia (HP:0005736)1.82185093
151Aplastic anemia (HP:0001915)1.81785163
152Striae distensae (HP:0001065)1.81410180
153Absent forearm bone (HP:0003953)1.80608651
154Aplasia involving forearm bones (HP:0009822)1.80608651
155Sandal gap (HP:0001852)1.80253939
156Cystic hygroma (HP:0000476)1.79831962
157Arterial tortuosity (HP:0005116)1.79432583
158Spinal cord compression (HP:0002176)1.77563561
159Abnormal hair whorl (HP:0010721)1.77368322
160Spinal muscular atrophy (HP:0007269)1.76852979
161Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74254994
162Adrenal overactivity (HP:0002717)1.74121610
163Hydroureter (HP:0000072)1.72976367
164Abnormality of incisor morphology (HP:0011063)1.71606035
165Abnormality of the pulmonary veins (HP:0011718)1.70648159
166Optic neuritis (HP:0100653)1.70029056
167Retrobulbar optic neuritis (HP:0100654)1.70029056
168Irregular epiphyses (HP:0010582)1.69851778
169Oligodactyly (HP:0012165)1.69415538
170Spondylolisthesis (HP:0003302)1.68785058
171Pendular nystagmus (HP:0012043)1.68204331
172Nephroblastoma (Wilms tumor) (HP:0002667)1.67776566
173Sparse lateral eyebrow (HP:0005338)1.67722647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.39935779
2LATS24.97031231
3MAP3K64.68516541
4STK38L4.65920413
5ERBB43.63632069
6TAOK33.28016799
7CDK83.00613239
8NEK62.98334550
9NTRK32.89365351
10FRK2.47763906
11PLK42.37519696
12PRKD32.36596054
13KSR22.31865046
14STK32.31119133
15CHEK22.08084105
16MUSK2.01245759
17TAOK11.96392852
18EPHA41.89876340
19MAP3K131.88756560
20CDC71.86367645
21MAP2K71.85794442
22MAP3K91.82504475
23TTK1.78929070
24BRAF1.78644868
25EEF2K1.67139040
26MET1.65181205
27TNIK1.61611507
28MAP3K41.52626499
29BRSK11.45618618
30MAPK131.45561766
31NEK21.44949287
32CAMKK21.43995182
33DYRK21.40731034
34STK381.40089961
35FGFR21.39244302
36RAF11.38376315
37PRKCI1.26716564
38TRIM281.25036720
39PRKD21.22169987
40MELK1.21034357
41DMPK1.20759678
42ABL21.18872437
43CDK121.09486658
44DAPK21.08844600
45CAMKK11.08804129
46ACVR1B1.07497545
47ARAF1.04809510
48PASK1.02179922
49STK241.00972553
50GRK11.00473183
51CDK51.00252168
52CDK91.00250089
53MST41.00079071
54WNK11.00052126
55CAMK10.99294307
56MAPKAPK30.89040174
57PTK20.89021703
58MOS0.86750519
59KSR10.86583152
60PAK60.85424296
61PLK10.85042294
62MAP2K40.82484065
63MAP3K50.81120205
64STK100.79430655
65STK390.75229316
66PRKCG0.74674300
67CAMK1D0.74305746
68TYRO30.73528837
69MAPKAPK50.72333980
70BRSK20.70860517
71CDK70.70399546
72PRKAA10.69969801
73PRKCZ0.69569173
74PINK10.68802752
75FGFR30.67612598
76NTRK20.67464983
77NUAK10.65406857
78PRKG10.64563187
79EIF2AK30.63470248
80JAK30.63400307
81PRKAA20.62627843
82TNK20.62424164
83MAPK110.61177217
84AURKB0.60295364
85CDK30.59931216
86CHEK10.59480456
87ATM0.59079150
88MAP3K20.58726865
89ABL10.57910401
90MAP3K80.57070375
91PDK10.56939800
92BMPR20.55498655
93PLK20.54743965
94UHMK10.54454907
95HIPK20.54363009
96GRK50.53740662
97RET0.51732380
98CSNK1G10.51725309
99DYRK1A0.50314831
100CSNK1E0.50086427
101PKN10.47575852
102SRPK10.47573148
103TRPM70.44811139
104CAMK40.44389642
105CAMK1G0.43942048
106AURKA0.43409031
107CDK190.43313962
108STK110.42217502
109PRKACA0.41256221
110MARK20.41163740
111BRD40.40838787
112PLK30.39967149
113OXSR10.39440126
114BMPR1B0.37781422
115FGR0.37084736
116VRK10.36926017
117CAMK2B0.36082490
118PAK10.35249294
119SGK20.34895617
120PRKACB0.34194616
121SGK10.32800523
122PIM10.31302792
123CDK10.30351886
124CDK20.29893415
125TGFBR10.29286421
126PTK2B0.29006632
127MTOR0.28542580
128CDK40.28238903
129AKT10.27085660
130CSNK1G20.26384455
131CSNK1D0.26057813
132NLK0.26032649
133MAP3K10.24135635
134ATR0.22729247
135MAPK100.19817362
136CSNK1G30.19517877
137MAPK140.19272106
138BUB10.18784106
139CHUK0.18574181
140MKNK20.16385399
141SGK4940.13493322
142SGK2230.13493322
143GSK3B0.13156434
144CAMK2A0.12978358
145KIT0.12514597
146MAPK10.12389790
147NEK90.10966522
148CSNK1A1L0.08515505
149JAK20.08486879
150CSNK1A10.08119767
151DYRK30.07461648

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.75608701
2Cell cycle_Homo sapiens_hsa041103.61279953
3Ovarian steroidogenesis_Homo sapiens_hsa049133.56736903
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.37423166
5Vitamin B6 metabolism_Homo sapiens_hsa007503.33982491
6RNA degradation_Homo sapiens_hsa030183.26945076
7Synaptic vesicle cycle_Homo sapiens_hsa047212.90537734
8Nicotine addiction_Homo sapiens_hsa050332.84463312
9Fanconi anemia pathway_Homo sapiens_hsa034602.83916432
10Homologous recombination_Homo sapiens_hsa034402.67124585
11Insulin secretion_Homo sapiens_hsa049112.57139035
12Pancreatic cancer_Homo sapiens_hsa052122.31470619
13Circadian rhythm_Homo sapiens_hsa047102.24558924
14GABAergic synapse_Homo sapiens_hsa047272.12797316
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00804768
16Linoleic acid metabolism_Homo sapiens_hsa005911.99313398
17p53 signaling pathway_Homo sapiens_hsa041151.98427694
18Dorso-ventral axis formation_Homo sapiens_hsa043201.96681407
19RNA polymerase_Homo sapiens_hsa030201.95343323
20Morphine addiction_Homo sapiens_hsa050321.94909792
21Olfactory transduction_Homo sapiens_hsa047401.88692633
22Phototransduction_Homo sapiens_hsa047441.85062894
23Ether lipid metabolism_Homo sapiens_hsa005651.81073993
24TGF-beta signaling pathway_Homo sapiens_hsa043501.75451674
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71568306
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68913755
27Gap junction_Homo sapiens_hsa045401.66796126
28Amphetamine addiction_Homo sapiens_hsa050311.65159891
29Base excision repair_Homo sapiens_hsa034101.64995184
30Prolactin signaling pathway_Homo sapiens_hsa049171.62547795
31Circadian entrainment_Homo sapiens_hsa047131.56469250
32MicroRNAs in cancer_Homo sapiens_hsa052061.54538139
33Colorectal cancer_Homo sapiens_hsa052101.52703528
34GnRH signaling pathway_Homo sapiens_hsa049121.50205364
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50018509
36Folate biosynthesis_Homo sapiens_hsa007901.46321629
37Taste transduction_Homo sapiens_hsa047421.46291973
38Long-term potentiation_Homo sapiens_hsa047201.43305978
39Non-homologous end-joining_Homo sapiens_hsa034501.40364025
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38145267
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37828132
42Nucleotide excision repair_Homo sapiens_hsa034201.34764141
43Choline metabolism in cancer_Homo sapiens_hsa052311.34391877
44Oocyte meiosis_Homo sapiens_hsa041141.34207226
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33643582
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29501599
47Caffeine metabolism_Homo sapiens_hsa002321.29209803
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28317181
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24346996
50Dopaminergic synapse_Homo sapiens_hsa047281.23667049
51ABC transporters_Homo sapiens_hsa020101.20460568
52Collecting duct acid secretion_Homo sapiens_hsa049661.20252262
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11372946
54* RNA transport_Homo sapiens_hsa030131.11322814
55Renal cell carcinoma_Homo sapiens_hsa052111.09032158
56Inositol phosphate metabolism_Homo sapiens_hsa005621.06407731
57Bile secretion_Homo sapiens_hsa049761.04504759
58Cocaine addiction_Homo sapiens_hsa050301.03630385
59Sphingolipid metabolism_Homo sapiens_hsa006001.03493745
60Oxytocin signaling pathway_Homo sapiens_hsa049210.99216441
61Salivary secretion_Homo sapiens_hsa049700.98850826
62mRNA surveillance pathway_Homo sapiens_hsa030150.98115714
63Type II diabetes mellitus_Homo sapiens_hsa049300.97410380
64Non-small cell lung cancer_Homo sapiens_hsa052230.96755308
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96347337
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94346019
67Gastric acid secretion_Homo sapiens_hsa049710.93157975
68Mismatch repair_Homo sapiens_hsa034300.92097955
69VEGF signaling pathway_Homo sapiens_hsa043700.91909240
70Ras signaling pathway_Homo sapiens_hsa040140.90967649
71Cholinergic synapse_Homo sapiens_hsa047250.90596861
72DNA replication_Homo sapiens_hsa030300.89887112
73FoxO signaling pathway_Homo sapiens_hsa040680.89135323
74Endometrial cancer_Homo sapiens_hsa052130.88808156
75Bladder cancer_Homo sapiens_hsa052190.88068117
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87773861
77Melanoma_Homo sapiens_hsa052180.84530711
78Renin secretion_Homo sapiens_hsa049240.84268076
79Fatty acid elongation_Homo sapiens_hsa000620.83331551
80Herpes simplex infection_Homo sapiens_hsa051680.82647666
81Small cell lung cancer_Homo sapiens_hsa052220.82305459
82Calcium signaling pathway_Homo sapiens_hsa040200.81798288
83Hepatitis B_Homo sapiens_hsa051610.81711678
84Thyroid cancer_Homo sapiens_hsa052160.80776180
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.80259213
86Hippo signaling pathway_Homo sapiens_hsa043900.79857963
87Adherens junction_Homo sapiens_hsa045200.77330538
88Other glycan degradation_Homo sapiens_hsa005110.76694057
89Purine metabolism_Homo sapiens_hsa002300.76148567
90Chronic myeloid leukemia_Homo sapiens_hsa052200.76078515
91Long-term depression_Homo sapiens_hsa047300.75534550
92Arachidonic acid metabolism_Homo sapiens_hsa005900.75476946
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74438731
94* mTOR signaling pathway_Homo sapiens_hsa041500.72222708
95Notch signaling pathway_Homo sapiens_hsa043300.71644308
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68657612
97Pancreatic secretion_Homo sapiens_hsa049720.68561478
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68494189
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66806815
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66771078
101ErbB signaling pathway_Homo sapiens_hsa040120.66385878
102Lysine degradation_Homo sapiens_hsa003100.66374897
103Butanoate metabolism_Homo sapiens_hsa006500.66038352
104Prostate cancer_Homo sapiens_hsa052150.65963944
105Pyrimidine metabolism_Homo sapiens_hsa002400.62786033
106HTLV-I infection_Homo sapiens_hsa051660.60880575
107Shigellosis_Homo sapiens_hsa051310.60691492
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60201921
109MAPK signaling pathway_Homo sapiens_hsa040100.58925704
110TNF signaling pathway_Homo sapiens_hsa046680.58906173
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.55919664
112Malaria_Homo sapiens_hsa051440.55104317
113Melanogenesis_Homo sapiens_hsa049160.54460223
114Wnt signaling pathway_Homo sapiens_hsa043100.52852678
115Serotonergic synapse_Homo sapiens_hsa047260.51742627
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51671944
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.50774436
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47293718
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45269719
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45118091
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45044757
122Glioma_Homo sapiens_hsa052140.43830338
123cAMP signaling pathway_Homo sapiens_hsa040240.42639593
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41330077
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.39490906
126Pathways in cancer_Homo sapiens_hsa052000.38184789
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37833759
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.37590695
129Cardiac muscle contraction_Homo sapiens_hsa042600.36551993
130Arginine and proline metabolism_Homo sapiens_hsa003300.36412380
131Chemokine signaling pathway_Homo sapiens_hsa040620.34817177
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33363547
133Glutamatergic synapse_Homo sapiens_hsa047240.33044254
134Influenza A_Homo sapiens_hsa051640.32252415
135Apoptosis_Homo sapiens_hsa042100.31965103
136Vitamin digestion and absorption_Homo sapiens_hsa049770.31627574
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31290754
138Mineral absorption_Homo sapiens_hsa049780.29638723
139Vibrio cholerae infection_Homo sapiens_hsa051100.29620804
140Tight junction_Homo sapiens_hsa045300.27916707
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.27811008
142Thyroid hormone synthesis_Homo sapiens_hsa049180.27311581
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26767286
144Regulation of autophagy_Homo sapiens_hsa041400.26601246
145Estrogen signaling pathway_Homo sapiens_hsa049150.26165718
146AMPK signaling pathway_Homo sapiens_hsa041520.25358067
147Epstein-Barr virus infection_Homo sapiens_hsa051690.25051328
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22673385
149Rap1 signaling pathway_Homo sapiens_hsa040150.20317110
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19798476
151Viral carcinogenesis_Homo sapiens_hsa052030.19613239
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17752064

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