

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proline biosynthetic process (GO:0006561) | 6.55500997 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.53458082 |
| 3 | DNA deamination (GO:0045006) | 5.90803610 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 5.77953284 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.60030725 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 5.60030725 |
| 7 | establishment of integrated proviral latency (GO:0075713) | 5.41830548 |
| 8 | transcription from mitochondrial promoter (GO:0006390) | 5.34500966 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 5.20466482 |
| 10 | replication fork processing (GO:0031297) | 5.00040171 |
| 11 | formation of translation preinitiation complex (GO:0001731) | 4.99331590 |
| 12 | embryonic process involved in female pregnancy (GO:0060136) | 4.91789052 |
| 13 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.90536257 |
| 14 | negative regulation of ligase activity (GO:0051352) | 4.84401906 |
| 15 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.84401906 |
| 16 | respiratory electron transport chain (GO:0022904) | 4.81334373 |
| 17 | proline metabolic process (GO:0006560) | 4.80786428 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.71603337 |
| 19 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.70985530 |
| 20 | electron transport chain (GO:0022900) | 4.69980321 |
| 21 | establishment of viral latency (GO:0019043) | 4.64404259 |
| 22 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.51798528 |
| 23 | protein neddylation (GO:0045116) | 4.49327585 |
| 24 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 4.49015658 |
| 25 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.47941363 |
| 26 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.40756367 |
| 27 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 4.36211338 |
| 28 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 4.36211338 |
| 29 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.29754192 |
| 30 | rRNA modification (GO:0000154) | 4.24708998 |
| 31 | positive regulation of protein homooligomerization (GO:0032464) | 4.21916875 |
| 32 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.17471021 |
| 33 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.17471021 |
| 34 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.17169978 |
| 35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.17169978 |
| 36 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.17169978 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.12114466 |
| 38 | viral mRNA export from host cell nucleus (GO:0046784) | 4.02945447 |
| 39 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.01951203 |
| 40 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.01951203 |
| 41 | cotranslational protein targeting to membrane (GO:0006613) | 4.01391376 |
| 42 | protein targeting to ER (GO:0045047) | 4.00985571 |
| 43 | regulation of integrin activation (GO:0033623) | 3.97959928 |
| 44 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.96502305 |
| 45 | mitotic G1 DNA damage checkpoint (GO:0031571) | 3.96480102 |
| 46 | establishment of apical/basal cell polarity (GO:0035089) | 3.95547005 |
| 47 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.93246505 |
| 48 | DNA strand elongation (GO:0022616) | 3.90164755 |
| 49 | protein deneddylation (GO:0000338) | 3.89241148 |
| 50 | positive regulation of ligase activity (GO:0051351) | 3.87973135 |
| 51 | protein complex biogenesis (GO:0070271) | 3.86323285 |
| 52 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.84229130 |
| 53 | mitochondrial DNA metabolic process (GO:0032042) | 3.83046943 |
| 54 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.82851174 |
| 55 | telomere maintenance via recombination (GO:0000722) | 3.81386798 |
| 56 | translation (GO:0006412) | 3.81012908 |
| 57 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.79476827 |
| 58 | protein localization to endoplasmic reticulum (GO:0070972) | 3.76111957 |
| 59 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.76034188 |
| 60 | protein targeting to mitochondrion (GO:0006626) | 3.68870031 |
| 61 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.68084876 |
| 62 | regulation of mitochondrial translation (GO:0070129) | 3.66901482 |
| 63 | viral transcription (GO:0019083) | 3.66308824 |
| 64 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.66147756 |
| 65 | termination of RNA polymerase III transcription (GO:0006386) | 3.66147756 |
| 66 | DNA damage response, detection of DNA damage (GO:0042769) | 3.65672012 |
| 67 | DNA strand renaturation (GO:0000733) | 3.64985411 |
| 68 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.61245662 |
| 69 | rRNA methylation (GO:0031167) | 3.60868083 |
| 70 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.60691397 |
| 71 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.59989344 |
| 72 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.58957130 |
| 73 | NADH dehydrogenase complex assembly (GO:0010257) | 3.58957130 |
| 74 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.58957130 |
| 75 | regulation of ligase activity (GO:0051340) | 3.58256200 |
| 76 | base-excision repair (GO:0006284) | 3.55636422 |
| 77 | mitotic G1/S transition checkpoint (GO:0044819) | 3.55388097 |
| 78 | translational termination (GO:0006415) | 3.54267466 |
| 79 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.52919436 |
| 80 | kinetochore assembly (GO:0051382) | 3.51627825 |
| 81 | maturation of 5.8S rRNA (GO:0000460) | 3.51034774 |
| 82 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.50157521 |
| 83 | G1 DNA damage checkpoint (GO:0044783) | 3.49033586 |
| 84 | regulation of translational fidelity (GO:0006450) | 3.48967987 |
| 85 | oxidative phosphorylation (GO:0006119) | 3.48660785 |
| 86 | protein localization to mitochondrion (GO:0070585) | 3.47842023 |
| 87 | establishment of protein localization to mitochondrion (GO:0072655) | 3.47206497 |
| 88 | inner mitochondrial membrane organization (GO:0007007) | 3.45086639 |
| 89 | oxidative demethylation (GO:0070989) | 3.41686505 |
| 90 | mitotic recombination (GO:0006312) | 3.38955057 |
| 91 | telomere maintenance via telomere lengthening (GO:0010833) | 3.38252091 |
| 92 | ribosome biogenesis (GO:0042254) | 3.37455205 |
| 93 | regulation of gene silencing by RNA (GO:0060966) | 3.37186845 |
| 94 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.37186845 |
| 95 | regulation of gene silencing by miRNA (GO:0060964) | 3.37186845 |
| 96 | mRNA cleavage (GO:0006379) | 3.36399469 |
| 97 | * translational initiation (GO:0006413) | 3.35802706 |
| 98 | termination of RNA polymerase II transcription (GO:0006369) | 3.34877279 |
| 99 | negative regulation of protein ubiquitination (GO:0031397) | 3.34462915 |
| 100 | 7-methylguanosine mRNA capping (GO:0006370) | 3.34152310 |
| 101 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.33859923 |
| 102 | ribosomal large subunit biogenesis (GO:0042273) | 3.33173759 |
| 103 | establishment of monopolar cell polarity (GO:0061162) | 3.30206137 |
| 104 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 3.30206137 |
| 105 | DNA integration (GO:0015074) | 3.29501220 |
| 106 | respiratory chain complex IV assembly (GO:0008535) | 3.27320388 |
| 107 | translational elongation (GO:0006414) | 3.26658874 |
| 108 | DNA double-strand break processing (GO:0000729) | 3.26042198 |
| 109 | meiotic chromosome segregation (GO:0045132) | 3.25523516 |
| 110 | sequestering of actin monomers (GO:0042989) | 3.25320549 |
| 111 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.24305282 |
| 112 | non-recombinational repair (GO:0000726) | 3.24305282 |
| 113 | regulation of protein homooligomerization (GO:0032462) | 3.24207068 |
| 114 | regulation of cellular amine metabolic process (GO:0033238) | 3.24192757 |
| 115 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.23630466 |
| 116 | RNA capping (GO:0036260) | 3.22683791 |
| 117 | 7-methylguanosine RNA capping (GO:0009452) | 3.22683791 |
| 118 | maturation of SSU-rRNA (GO:0030490) | 3.22318995 |
| 119 | cytochrome complex assembly (GO:0017004) | 3.21189519 |
| 120 | kinetochore organization (GO:0051383) | 3.20230984 |
| 121 | ribosome assembly (GO:0042255) | 3.19991843 |
| 122 | ATP biosynthetic process (GO:0006754) | 3.19901512 |
| 123 | CTP biosynthetic process (GO:0006241) | 3.19714881 |
| 124 | CTP metabolic process (GO:0046036) | 3.19714881 |
| 125 | rRNA processing (GO:0006364) | 3.18235671 |
| 126 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.17929558 |
| 127 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.17902822 |
| 128 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.17839850 |
| 129 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 3.17356292 |
| 130 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.16417015 |
| 131 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.16417015 |
| 132 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.16417015 |
| 133 | positive regulation of cell cycle arrest (GO:0071158) | 3.14768990 |
| 134 | mitotic sister chromatid segregation (GO:0000070) | 3.12145583 |
| 135 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.11889991 |
| 136 | mitotic nuclear envelope disassembly (GO:0007077) | 3.11829762 |
| 137 | GTP biosynthetic process (GO:0006183) | 3.11573638 |
| 138 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.11435570 |
| 139 | cellular component biogenesis (GO:0044085) | 3.09507532 |
| 140 | ribosomal small subunit biogenesis (GO:0042274) | 3.09164456 |
| 141 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.08777422 |
| 142 | DNA replication initiation (GO:0006270) | 3.08013162 |
| 143 | spliceosomal snRNP assembly (GO:0000387) | 3.07638964 |
| 144 | positive regulation of chromosome segregation (GO:0051984) | 3.07494871 |
| 145 | rRNA metabolic process (GO:0016072) | 3.07382840 |
| 146 | mitochondrial RNA metabolic process (GO:0000959) | 3.06367064 |
| 147 | proteasome assembly (GO:0043248) | 3.06267845 |
| 148 | cullin deneddylation (GO:0010388) | 3.06186782 |
| 149 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.06129071 |
| 150 | hydrogen ion transmembrane transport (GO:1902600) | 3.05866914 |
| 151 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.04733502 |
| 152 | regulation of double-strand break repair (GO:2000779) | 3.03673891 |
| 153 | poly(A)+ mRNA export from nucleus (GO:0016973) | 3.02352894 |
| 154 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.98867566 |
| 155 | negative regulation of cell cycle arrest (GO:0071157) | 2.98680022 |
| 156 | cellular protein complex disassembly (GO:0043624) | 2.98466465 |
| 157 | IMP biosynthetic process (GO:0006188) | 2.97386122 |
| 158 | negative regulation of mRNA processing (GO:0050686) | 2.97344929 |
| 159 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.94976780 |
| 160 | ribosomal small subunit assembly (GO:0000028) | 2.94765949 |
| 161 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.94116959 |
| 162 | base-excision repair, AP site formation (GO:0006285) | 2.92245746 |
| 163 | pseudouridine synthesis (GO:0001522) | 2.91716846 |
| 164 | DNA ligation (GO:0006266) | 2.91051007 |
| 165 | mitotic nuclear envelope reassembly (GO:0007084) | 2.90521295 |
| 166 | nuclear envelope reassembly (GO:0031468) | 2.90521295 |
| 167 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.90327149 |
| 168 | positive regulation of protein oligomerization (GO:0032461) | 2.87923127 |
| 169 | nuclear envelope disassembly (GO:0051081) | 2.84883047 |
| 170 | membrane disassembly (GO:0030397) | 2.84883047 |
| 171 | DNA topological change (GO:0006265) | 2.81383545 |
| 172 | positive regulation of developmental pigmentation (GO:0048087) | 2.81207054 |
| 173 | DNA replication checkpoint (GO:0000076) | 2.81097805 |
| 174 | apoptotic process involved in morphogenesis (GO:0060561) | 2.80788579 |
| 175 | negative regulation of RNA splicing (GO:0033119) | 2.80359992 |
| 176 | regulation of sister chromatid cohesion (GO:0007063) | 2.79890966 |
| 177 | regulation of RNA export from nucleus (GO:0046831) | 2.78042451 |
| 178 | trophectodermal cell differentiation (GO:0001829) | 2.77453513 |
| 179 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.76088423 |
| 180 | single strand break repair (GO:0000012) | 2.75608469 |
| 181 | nodal signaling pathway (GO:0038092) | 2.75134166 |
| 182 | viral life cycle (GO:0019058) | 2.74914736 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.47374848 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.73628363 |
| 3 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.02298003 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.26824009 |
| 5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.06483426 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.92191917 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.86467684 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.79830654 |
| 9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.76019241 |
| 10 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.61868581 |
| 11 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.60638494 |
| 12 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.46769623 |
| 13 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.43624415 |
| 14 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.41614200 |
| 15 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.41614200 |
| 16 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.41614200 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.36461190 |
| 18 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.34838517 |
| 19 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.34564960 |
| 20 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.28706680 |
| 21 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.11884173 |
| 22 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.09349777 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.09134800 |
| 24 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.01406464 |
| 25 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.00704414 |
| 26 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.99800735 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.96969557 |
| 28 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96579977 |
| 29 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.93209304 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.92839543 |
| 31 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.92727807 |
| 32 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.87310097 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.86525234 |
| 34 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.84526033 |
| 35 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.83306283 |
| 36 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.83077874 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.81522466 |
| 38 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.77720633 |
| 39 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.75372283 |
| 40 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.73791422 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.73673970 |
| 42 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.73618315 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70807942 |
| 44 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.69681195 |
| 45 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.68354777 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.68258421 |
| 47 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.66249139 |
| 48 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.66016649 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.65222975 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.64268561 |
| 51 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.63828692 |
| 52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.62837334 |
| 53 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.62583826 |
| 54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.61601805 |
| 55 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.60900810 |
| 56 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.60652957 |
| 57 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.55193178 |
| 58 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.47535845 |
| 59 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.47276148 |
| 60 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.45189871 |
| 61 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.45140969 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.44415991 |
| 63 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.43634847 |
| 64 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.42257156 |
| 65 | MYC_22102868_ChIP-Seq_BL_Human | 1.40462818 |
| 66 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.36591986 |
| 67 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.36562019 |
| 68 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.36223216 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.34468260 |
| 70 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.33470074 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.33095285 |
| 72 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32648137 |
| 73 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32070508 |
| 74 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.31800429 |
| 75 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.29467235 |
| 76 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.28930658 |
| 77 | * POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.28387674 |
| 78 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.27678755 |
| 79 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27133159 |
| 80 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.26898145 |
| 81 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.23320715 |
| 82 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23190521 |
| 83 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.23111624 |
| 84 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.20747340 |
| 85 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.19606534 |
| 86 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.17573700 |
| 87 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.17187236 |
| 88 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.16487960 |
| 89 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.16072400 |
| 90 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13312773 |
| 91 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 1.12891699 |
| 92 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.09740873 |
| 93 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.09282818 |
| 94 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.08129792 |
| 95 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.07229748 |
| 96 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06947322 |
| 97 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.06736004 |
| 98 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.06577232 |
| 99 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05777953 |
| 100 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.05172915 |
| 101 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.04075492 |
| 102 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.03893440 |
| 103 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.03017225 |
| 104 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.02774717 |
| 105 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 1.01740966 |
| 106 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99956830 |
| 107 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.99949563 |
| 108 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.99827288 |
| 109 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.99767305 |
| 110 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.98402202 |
| 111 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.97803416 |
| 112 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.97796874 |
| 113 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.97619781 |
| 114 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97351622 |
| 115 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.97000284 |
| 116 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.94971211 |
| 117 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.93158085 |
| 118 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92469775 |
| 119 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.92278073 |
| 120 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92124956 |
| 121 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.91364255 |
| 122 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.90626187 |
| 123 | NANOG_18692474_ChIP-Seq_MESCs_Mouse | 0.90594004 |
| 124 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.90022573 |
| 125 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.89941151 |
| 126 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.89499927 |
| 127 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89428066 |
| 128 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.81792914 |
| 129 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.81623873 |
| 130 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.79524860 |
| 131 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.73772788 |
| 132 | VDR_22108803_ChIP-Seq_LS180_Human | 0.72723191 |
| 133 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.69105328 |
| 134 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.68563416 |
| 135 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.67434758 |
| 136 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.65162964 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 5.38831813 |
| 2 | MP0010030_abnormal_orbit_morphology | 3.50076015 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.37027555 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.26709956 |
| 5 | MP0003693_abnormal_embryo_hatching | 3.17180426 |
| 6 | MP0006292_abnormal_olfactory_placode | 3.07550597 |
| 7 | MP0003111_abnormal_nucleus_morphology | 3.00530522 |
| 8 | MP0003011_delayed_dark_adaptation | 2.71042274 |
| 9 | MP0003077_abnormal_cell_cycle | 2.65795096 |
| 10 | MP0009278_abnormal_bone_marrow | 2.61052183 |
| 11 | MP0008058_abnormal_DNA_repair | 2.60080721 |
| 12 | MP0000749_muscle_degeneration | 2.59665658 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.54778664 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.51041859 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.50337574 |
| 16 | MP0006036_abnormal_mitochondrial_physio | 2.48829263 |
| 17 | MP0000372_irregular_coat_pigmentation | 2.38390746 |
| 18 | MP0008932_abnormal_embryonic_tissue | 2.30114897 |
| 19 | MP0005171_absent_coat_pigmentation | 2.29038680 |
| 20 | MP0009697_abnormal_copulation | 2.25671913 |
| 21 | MP0005084_abnormal_gallbladder_morpholo | 2.17347982 |
| 22 | MP0002938_white_spotting | 2.10947416 |
| 23 | MP0003786_premature_aging | 2.08957398 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.90162023 |
| 25 | MP0004233_abnormal_muscle_weight | 1.84668996 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.79217731 |
| 27 | MP0005076_abnormal_cell_differentiation | 1.77442753 |
| 28 | MP0004133_heterotaxia | 1.75372544 |
| 29 | MP0001730_embryonic_growth_arrest | 1.72126304 |
| 30 | MP0005397_hematopoietic_system_phenotyp | 1.69929735 |
| 31 | MP0001545_abnormal_hematopoietic_system | 1.69929735 |
| 32 | MP0000490_abnormal_crypts_of | 1.69147155 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.64931418 |
| 34 | MP0008260_abnormal_autophagy | 1.64225424 |
| 35 | MP0001697_abnormal_embryo_size | 1.63105227 |
| 36 | MP0004197_abnormal_fetal_growth/weight/ | 1.62944379 |
| 37 | MP0008007_abnormal_cellular_replicative | 1.59000074 |
| 38 | MP0001293_anophthalmia | 1.58311676 |
| 39 | MP0002086_abnormal_extraembryonic_tissu | 1.58224891 |
| 40 | MP0003567_abnormal_fetal_cardiomyocyte | 1.57796666 |
| 41 | MP0002653_abnormal_ependyma_morphology | 1.56719297 |
| 42 | MP0000750_abnormal_muscle_regeneration | 1.55819335 |
| 43 | MP0003890_abnormal_embryonic-extraembry | 1.54192170 |
| 44 | MP0006054_spinal_hemorrhage | 1.52490568 |
| 45 | MP0002085_abnormal_embryonic_tissue | 1.51639443 |
| 46 | MP0005380_embryogenesis_phenotype | 1.51137776 |
| 47 | MP0001672_abnormal_embryogenesis/_devel | 1.51137776 |
| 48 | MP0003195_calcinosis | 1.48009895 |
| 49 | MP0002277_abnormal_respiratory_mucosa | 1.47691348 |
| 50 | MP0002084_abnormal_developmental_patter | 1.47617465 |
| 51 | MP0003806_abnormal_nucleotide_metabolis | 1.47111067 |
| 52 | MP0005257_abnormal_intraocular_pressure | 1.45370407 |
| 53 | MP0002837_dystrophic_cardiac_calcinosis | 1.42622278 |
| 54 | MP0002249_abnormal_larynx_morphology | 1.41661132 |
| 55 | MP0002009_preneoplasia | 1.38995957 |
| 56 | MP0001853_heart_inflammation | 1.37489426 |
| 57 | MP0005671_abnormal_response_to | 1.36786129 |
| 58 | MP0002282_abnormal_trachea_morphology | 1.36093820 |
| 59 | MP0005253_abnormal_eye_physiology | 1.34034018 |
| 60 | MP0000358_abnormal_cell_content/ | 1.32946566 |
| 61 | MP0003119_abnormal_digestive_system | 1.32271581 |
| 62 | MP0003453_abnormal_keratinocyte_physiol | 1.30277978 |
| 63 | MP0002139_abnormal_hepatobiliary_system | 1.28816815 |
| 64 | MP0002736_abnormal_nociception_after | 1.28626864 |
| 65 | MP0003984_embryonic_growth_retardation | 1.28538466 |
| 66 | MP0010307_abnormal_tumor_latency | 1.26531219 |
| 67 | MP0002080_prenatal_lethality | 1.26491428 |
| 68 | MP0009333_abnormal_splenocyte_physiolog | 1.26238257 |
| 69 | MP0008877_abnormal_DNA_methylation | 1.25782851 |
| 70 | MP0002396_abnormal_hematopoietic_system | 1.25223907 |
| 71 | MP0002088_abnormal_embryonic_growth/wei | 1.24331478 |
| 72 | MP0009384_cardiac_valve_regurgitation | 1.24267829 |
| 73 | MP0002019_abnormal_tumor_incidence | 1.24064581 |
| 74 | MP0003718_maternal_effect | 1.23628446 |
| 75 | MP0008995_early_reproductive_senescence | 1.22849730 |
| 76 | MP0009785_altered_susceptibility_to | 1.21218107 |
| 77 | MP0003941_abnormal_skin_development | 1.18612027 |
| 78 | MP0003705_abnormal_hypodermis_morpholog | 1.18300293 |
| 79 | MP0002148_abnormal_hypersensitivity_rea | 1.17716503 |
| 80 | MP0001529_abnormal_vocalization | 1.16038174 |
| 81 | MP0005023_abnormal_wound_healing | 1.13882076 |
| 82 | MP0002111_abnormal_tail_morphology | 1.13684452 |
| 83 | MP0000313_abnormal_cell_death | 1.11901722 |
| 84 | MP0009053_abnormal_anal_canal | 1.11287970 |
| 85 | MP0002254_reproductive_system_inflammat | 1.09660230 |
| 86 | MP0005499_abnormal_olfactory_system | 1.09513032 |
| 87 | MP0005394_taste/olfaction_phenotype | 1.09513032 |
| 88 | MP0002090_abnormal_vision | 1.08786613 |
| 89 | MP0003566_abnormal_cell_adhesion | 1.08579133 |
| 90 | MP0004142_abnormal_muscle_tone | 1.06604278 |
| 91 | MP0005174_abnormal_tail_pigmentation | 1.03765710 |
| 92 | MP0003828_pulmonary_edema | 1.03673250 |
| 93 | MP0003283_abnormal_digestive_organ | 0.99453660 |
| 94 | MP0005408_hypopigmentation | 0.98521750 |
| 95 | MP0005365_abnormal_bile_salt | 0.97918760 |
| 96 | MP0000685_abnormal_immune_system | 0.96237224 |
| 97 | MP0002102_abnormal_ear_morphology | 0.94506263 |
| 98 | MP0002405_respiratory_system_inflammati | 0.93058827 |
| 99 | MP0001145_abnormal_male_reproductive | 0.92542651 |
| 100 | MP0000470_abnormal_stomach_morphology | 0.91409694 |
| 101 | MP0005360_urolithiasis | 0.91052006 |
| 102 | MP0005391_vision/eye_phenotype | 0.90710313 |
| 103 | MP0001346_abnormal_lacrimal_gland | 0.89969026 |
| 104 | MP0000762_abnormal_tongue_morphology | 0.89965223 |
| 105 | MP0005085_abnormal_gallbladder_physiolo | 0.89501008 |
| 106 | MP0000371_diluted_coat_color | 0.88859528 |
| 107 | MP0002233_abnormal_nose_morphology | 0.88705257 |
| 108 | MP0002210_abnormal_sex_determination | 0.87613313 |
| 109 | MP0000049_abnormal_middle_ear | 0.87120376 |
| 110 | MP0002269_muscular_atrophy | 0.87118665 |
| 111 | MP0003221_abnormal_cardiomyocyte_apopto | 0.85352683 |
| 112 | MP0005508_abnormal_skeleton_morphology | 0.85042620 |
| 113 | MP0006082_CNS_inflammation | 0.84628664 |
| 114 | MP0001764_abnormal_homeostasis | 0.84422158 |
| 115 | MP0003755_abnormal_palate_morphology | 0.84065078 |
| 116 | MP0002932_abnormal_joint_morphology | 0.83130251 |
| 117 | MP0005501_abnormal_skin_physiology | 0.83072709 |
| 118 | MP0005330_cardiomyopathy | 0.82479996 |
| 119 | MP0004145_abnormal_muscle_electrophysio | 0.81897131 |
| 120 | MP0002163_abnormal_gland_morphology | 0.81250240 |
| 121 | MP0001790_abnormal_immune_system | 0.80600202 |
| 122 | MP0005387_immune_system_phenotype | 0.80600202 |
| 123 | MP0005410_abnormal_fertilization | 0.80428377 |
| 124 | MP0002295_abnormal_pulmonary_circulatio | 0.79942072 |
| 125 | MP0001286_abnormal_eye_development | 0.79785348 |
| 126 | MP0000432_abnormal_head_morphology | 0.79400058 |
| 127 | MP0003186_abnormal_redox_activity | 0.78939845 |
| 128 | MP0002060_abnormal_skin_morphology | 0.78311911 |
| 129 | MP0002114_abnormal_axial_skeleton | 0.77379834 |
| 130 | MP0001905_abnormal_dopamine_level | 0.76209695 |
| 131 | MP0002796_impaired_skin_barrier | 0.76110434 |
| 132 | MP0002132_abnormal_respiratory_system | 0.75480476 |
| 133 | MP0005083_abnormal_biliary_tract | 0.75471910 |
| 134 | MP0005075_abnormal_melanosome_morpholog | 0.73789658 |
| 135 | MP0001849_ear_inflammation | 0.73382479 |
| 136 | MP0002751_abnormal_autonomic_nervous | 0.72988578 |
| 137 | MP0003315_abnormal_perineum_morphology | 0.72908444 |
| 138 | MP0000689_abnormal_spleen_morphology | 0.72634201 |
| 139 | MP0009250_abnormal_appendicular_skeleto | 0.71858559 |
| 140 | MP0000751_myopathy | 0.70813535 |
| 141 | MP0002075_abnormal_coat/hair_pigmentati | 0.70791577 |
| 142 | MP0002697_abnormal_eye_size | 0.70670375 |
| 143 | MP0000747_muscle_weakness | 0.70399797 |
| 144 | MP0000703_abnormal_thymus_morphology | 0.70234297 |
| 145 | MP0005319_abnormal_enzyme/_coenzyme | 0.69970275 |
| 146 | MP0008438_abnormal_cutaneous_collagen | 0.67833738 |
| 147 | MP0002138_abnormal_hepatobiliary_system | 0.67741489 |
| 148 | MP0001727_abnormal_embryo_implantation | 0.67547949 |
| 149 | MP0001929_abnormal_gametogenesis | 0.67526713 |
| 150 | MP0001915_intracranial_hemorrhage | 0.67227692 |
| 151 | MP0003448_altered_tumor_morphology | 0.66558836 |
| 152 | MP0003936_abnormal_reproductive_system | 0.66548004 |
| 153 | MP0000653_abnormal_sex_gland | 0.66181903 |
| 154 | MP0005266_abnormal_metabolism | 0.65974219 |
| 155 | MP0000477_abnormal_intestine_morphology | 0.65618402 |
| 156 | MP0003385_abnormal_body_wall | 0.65614480 |
| 157 | MP0003935_abnormal_craniofacial_develop | 0.65291754 |
| 158 | MP0001666_abnormal_nutrient_absorption | 0.65191816 |
| 159 | MP0000015_abnormal_ear_pigmentation | 0.64725105 |
| 160 | MP0003136_yellow_coat_color | 0.64288036 |
| 161 | MP0002116_abnormal_craniofacial_bone | 0.64240426 |
| 162 | MP0000343_altered_response_to | 0.64221250 |
| 163 | MP0002722_abnormal_immune_system | 0.64077042 |
| 164 | MP0003122_maternal_imprinting | 0.63958269 |
| 165 | MP0001542_abnormal_bone_strength | 0.62307862 |
| 166 | MP0001186_pigmentation_phenotype | 0.61679809 |
| 167 | MP0002398_abnormal_bone_marrow | 0.61510807 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.02033790 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.47809389 |
| 3 | Acute encephalopathy (HP:0006846) | 5.39322503 |
| 4 | Mitochondrial inheritance (HP:0001427) | 5.04982590 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.70070691 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.65402292 |
| 7 | Increased CSF lactate (HP:0002490) | 4.63030560 |
| 8 | Rib fusion (HP:0000902) | 4.51877440 |
| 9 | Hepatic necrosis (HP:0002605) | 4.29721028 |
| 10 | Concave nail (HP:0001598) | 4.17756126 |
| 11 | Rectovaginal fistula (HP:0000143) | 4.07364618 |
| 12 | Rectal fistula (HP:0100590) | 4.07364618 |
| 13 | Cerebral edema (HP:0002181) | 4.04875006 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.89102224 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.89102224 |
| 16 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.89053142 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.86532148 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.84715621 |
| 19 | Pustule (HP:0200039) | 3.80538151 |
| 20 | Abnormal hemoglobin (HP:0011902) | 3.77168982 |
| 21 | Aplasia/hypoplasia of the humerus (HP:0006507) | 3.62911660 |
| 22 | Absent radius (HP:0003974) | 3.62907334 |
| 23 | Increased IgM level (HP:0003496) | 3.54486762 |
| 24 | Facial hemangioma (HP:0000329) | 3.51984000 |
| 25 | Intestinal fistula (HP:0100819) | 3.51228863 |
| 26 | Absent thumb (HP:0009777) | 3.50127017 |
| 27 | 3-Methylglutaconic aciduria (HP:0003535) | 3.50025214 |
| 28 | Patellar aplasia (HP:0006443) | 3.46534967 |
| 29 | Colon cancer (HP:0003003) | 3.44914190 |
| 30 | Selective tooth agenesis (HP:0001592) | 3.44085767 |
| 31 | Vaginal fistula (HP:0004320) | 3.43368266 |
| 32 | Poikiloderma (HP:0001029) | 3.42154771 |
| 33 | Absent forearm bone (HP:0003953) | 3.38931027 |
| 34 | Aplasia involving forearm bones (HP:0009822) | 3.38931027 |
| 35 | Alopecia of scalp (HP:0002293) | 3.38751782 |
| 36 | Short humerus (HP:0005792) | 3.37464773 |
| 37 | Aplastic anemia (HP:0001915) | 3.25598756 |
| 38 | Lactic acidosis (HP:0003128) | 3.25421552 |
| 39 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.23606553 |
| 40 | Increased serum pyruvate (HP:0003542) | 3.20774365 |
| 41 | Tongue fasciculations (HP:0001308) | 3.18640589 |
| 42 | Respiratory failure (HP:0002878) | 3.17811957 |
| 43 | Ulnar bowing (HP:0003031) | 3.13077828 |
| 44 | Renal Fanconi syndrome (HP:0001994) | 3.10890506 |
| 45 | Oral leukoplakia (HP:0002745) | 3.09744874 |
| 46 | Breast hypoplasia (HP:0003187) | 3.01683759 |
| 47 | Muscle fibrillation (HP:0010546) | 2.99562649 |
| 48 | Exercise intolerance (HP:0003546) | 2.96034336 |
| 49 | Premature graying of hair (HP:0002216) | 2.93674418 |
| 50 | Increased serum lactate (HP:0002151) | 2.90761843 |
| 51 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.88483493 |
| 52 | Squamous cell carcinoma (HP:0002860) | 2.86427773 |
| 53 | Leukodystrophy (HP:0002415) | 2.86289569 |
| 54 | Generalized aminoaciduria (HP:0002909) | 2.84728432 |
| 55 | Reticulocytopenia (HP:0001896) | 2.81839487 |
| 56 | Birth length less than 3rd percentile (HP:0003561) | 2.79375253 |
| 57 | Increased intramyocellular lipid droplets (HP:0012240) | 2.77567421 |
| 58 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.77090819 |
| 59 | Nemaline bodies (HP:0003798) | 2.76699122 |
| 60 | Optic disc pallor (HP:0000543) | 2.75396077 |
| 61 | Cellular immunodeficiency (HP:0005374) | 2.74723056 |
| 62 | Basal cell carcinoma (HP:0002671) | 2.74620267 |
| 63 | Coronal craniosynostosis (HP:0004440) | 2.73476032 |
| 64 | Abnormality of glycolysis (HP:0004366) | 2.73433474 |
| 65 | Dyschromatopsia (HP:0007641) | 2.73432451 |
| 66 | Lethargy (HP:0001254) | 2.71377939 |
| 67 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 2.68580501 |
| 68 | Vertebral hypoplasia (HP:0008417) | 2.68580501 |
| 69 | Aplasia of the musculature (HP:0100854) | 2.67230447 |
| 70 | Turricephaly (HP:0000262) | 2.63867169 |
| 71 | Exercise-induced muscle cramps (HP:0003710) | 2.61767249 |
| 72 | Hypoplasia of the radius (HP:0002984) | 2.55077381 |
| 73 | Orthostatic hypotension (HP:0001278) | 2.54315746 |
| 74 | Hyperglycinemia (HP:0002154) | 2.54252520 |
| 75 | Annular pancreas (HP:0001734) | 2.53698618 |
| 76 | Type I transferrin isoform profile (HP:0003642) | 2.52721538 |
| 77 | Respiratory difficulties (HP:0002880) | 2.52596923 |
| 78 | Trismus (HP:0000211) | 2.52429255 |
| 79 | Microvesicular hepatic steatosis (HP:0001414) | 2.52117506 |
| 80 | Muscle fiber inclusion bodies (HP:0100299) | 2.50111172 |
| 81 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.49328762 |
| 82 | Abnormality of the ileum (HP:0001549) | 2.48552320 |
| 83 | Muscle fiber atrophy (HP:0100295) | 2.48448476 |
| 84 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.45676347 |
| 85 | Redundant skin (HP:0001582) | 2.42878472 |
| 86 | Congenital hip dislocation (HP:0001374) | 2.42855286 |
| 87 | Hypochromic microcytic anemia (HP:0004840) | 2.41522153 |
| 88 | Abnormal number of erythroid precursors (HP:0012131) | 2.40590287 |
| 89 | Increased muscle lipid content (HP:0009058) | 2.40404047 |
| 90 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.39576545 |
| 91 | Intestinal atresia (HP:0011100) | 2.39425597 |
| 92 | Amniotic constriction ring (HP:0009775) | 2.38088701 |
| 93 | Abnormality of placental membranes (HP:0011409) | 2.38088701 |
| 94 | Abnormality of serum amino acid levels (HP:0003112) | 2.36045757 |
| 95 | Abnormality of the labia minora (HP:0012880) | 2.34437200 |
| 96 | X-linked dominant inheritance (HP:0001423) | 2.33221001 |
| 97 | Abnormality of the anterior horn cell (HP:0006802) | 2.26136694 |
| 98 | Degeneration of anterior horn cells (HP:0002398) | 2.26136694 |
| 99 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.25973578 |
| 100 | Abnormal number of incisors (HP:0011064) | 2.24453007 |
| 101 | Reduced antithrombin III activity (HP:0001976) | 2.23457257 |
| 102 | Methylmalonic acidemia (HP:0002912) | 2.22380554 |
| 103 | Vertebral fusion (HP:0002948) | 2.21842211 |
| 104 | CNS demyelination (HP:0007305) | 2.21829564 |
| 105 | Abnormality of male internal genitalia (HP:0000022) | 2.21400638 |
| 106 | Type 2 muscle fiber atrophy (HP:0003554) | 2.20760507 |
| 107 | Male infertility (HP:0003251) | 2.20157403 |
| 108 | Premature skin wrinkling (HP:0100678) | 2.19065900 |
| 109 | Cerebral hypomyelination (HP:0006808) | 2.16682199 |
| 110 | Pancytopenia (HP:0001876) | 2.14434525 |
| 111 | Methylmalonic aciduria (HP:0012120) | 2.13985346 |
| 112 | Bifid uvula (HP:0000193) | 2.13443853 |
| 113 | Popliteal pterygium (HP:0009756) | 2.12809811 |
| 114 | Rough bone trabeculation (HP:0100670) | 2.11886521 |
| 115 | Rhabdomyolysis (HP:0003201) | 2.10243334 |
| 116 | Calcaneovalgus deformity (HP:0001848) | 2.09382864 |
| 117 | Ependymoma (HP:0002888) | 2.09240457 |
| 118 | Delayed CNS myelination (HP:0002188) | 2.09022525 |
| 119 | Deformed tarsal bones (HP:0008119) | 2.08655662 |
| 120 | Hypochromic anemia (HP:0001931) | 2.08173655 |
| 121 | Broad alveolar ridges (HP:0000187) | 2.05604675 |
| 122 | Premature ovarian failure (HP:0008209) | 2.05421864 |
| 123 | Exertional dyspnea (HP:0002875) | 2.02478692 |
| 124 | Short chin (HP:0000331) | 2.00668830 |
| 125 | Carpal bone hypoplasia (HP:0001498) | 2.00201553 |
| 126 | Spinal muscular atrophy (HP:0007269) | 1.99235053 |
| 127 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.95904589 |
| 128 | Astrocytoma (HP:0009592) | 1.93264961 |
| 129 | Abnormality of the astrocytes (HP:0100707) | 1.93264961 |
| 130 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.92624459 |
| 131 | Abnormality of alanine metabolism (HP:0010916) | 1.92624459 |
| 132 | Hyperalaninemia (HP:0003348) | 1.92624459 |
| 133 | Abnormal trabecular bone morphology (HP:0100671) | 1.92209429 |
| 134 | Vitreoretinal degeneration (HP:0000655) | 1.89854421 |
| 135 | Capillary hemangiomas (HP:0005306) | 1.89465362 |
| 136 | Multiple enchondromatosis (HP:0005701) | 1.89228275 |
| 137 | Short thumb (HP:0009778) | 1.89195884 |
| 138 | Nausea (HP:0002018) | 1.88372842 |
| 139 | Distal arthrogryposis (HP:0005684) | 1.88350813 |
| 140 | Septo-optic dysplasia (HP:0100842) | 1.87861102 |
| 141 | Albinism (HP:0001022) | 1.87113469 |
| 142 | Emotional lability (HP:0000712) | 1.86946514 |
| 143 | Dicarboxylic aciduria (HP:0003215) | 1.86818619 |
| 144 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.86818619 |
| 145 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.86209136 |
| 146 | Carpal synostosis (HP:0009702) | 1.84952094 |
| 147 | Abnormality of abdominal situs (HP:0011620) | 1.84398005 |
| 148 | Abdominal situs inversus (HP:0003363) | 1.84398005 |
| 149 | Diaphragmatic weakness (HP:0009113) | 1.83814976 |
| 150 | Abnormality of glycine metabolism (HP:0010895) | 1.83803395 |
| 151 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.83803395 |
| 152 | Glycosuria (HP:0003076) | 1.83719182 |
| 153 | Abnormality of urine glucose concentration (HP:0011016) | 1.83719182 |
| 154 | Joint stiffness (HP:0001387) | 1.83307932 |
| 155 | Pallor (HP:0000980) | 1.82899746 |
| 156 | Abnormal protein glycosylation (HP:0012346) | 1.81321378 |
| 157 | Abnormal glycosylation (HP:0012345) | 1.81321378 |
| 158 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.81321378 |
| 159 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.81321378 |
| 160 | Macrocytic anemia (HP:0001972) | 1.81192457 |
| 161 | Hypotrichosis (HP:0001006) | 1.79365945 |
| 162 | Absent septum pellucidum (HP:0001331) | 1.78840328 |
| 163 | Abnormality of the septum pellucidum (HP:0007375) | 1.78707587 |
| 164 | Supernumerary spleens (HP:0009799) | 1.77449276 |
| 165 | Alacrima (HP:0000522) | 1.77442254 |
| 166 | Rhabdomyosarcoma (HP:0002859) | 1.76958034 |
| 167 | Hyperglycinuria (HP:0003108) | 1.76498182 |
| 168 | Dysautonomia (HP:0002459) | 1.76251365 |
| 169 | Stenosis of the external auditory canal (HP:0000402) | 1.75781669 |
| 170 | Hypotelorism (HP:0000601) | 1.75097632 |
| 171 | Secondary amenorrhea (HP:0000869) | 1.74008244 |
| 172 | Increased number of teeth (HP:0011069) | 1.73609626 |
| 173 | Recurrent cutaneous fungal infections (HP:0011370) | 1.73308604 |
| 174 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.73308604 |
| 175 | Meckel diverticulum (HP:0002245) | 1.72919964 |
| 176 | Abnormality of methionine metabolism (HP:0010901) | 1.72590480 |
| 177 | Generalized amyotrophy (HP:0003700) | 1.72468352 |
| 178 | Agnosia (HP:0010524) | 1.72423519 |
| 179 | IgA deficiency (HP:0002720) | 1.71097701 |
| 180 | Choanal stenosis (HP:0000452) | 1.68367462 |
| 181 | Breech presentation (HP:0001623) | 1.68190400 |
| 182 | Acute lymphatic leukemia (HP:0006721) | 1.67171463 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.48891985 |
| 2 | ICK | 4.42163610 |
| 3 | STK16 | 4.40535128 |
| 4 | DDR2 | 3.90863999 |
| 5 | MAP3K11 | 3.21747689 |
| 6 | TXK | 3.17789241 |
| 7 | MAP3K12 | 2.89563816 |
| 8 | BUB1 | 2.84631333 |
| 9 | PIM2 | 2.82750519 |
| 10 | MAP3K6 | 2.75812096 |
| 11 | MAPK15 | 2.57521626 |
| 12 | EIF2AK1 | 2.57295898 |
| 13 | WEE1 | 2.30037812 |
| 14 | CDK7 | 2.27373161 |
| 15 | TAF1 | 2.24927397 |
| 16 | PINK1 | 2.17193047 |
| 17 | MATK | 1.99480116 |
| 18 | BMX | 1.98490856 |
| 19 | FGR | 1.94971523 |
| 20 | NUAK1 | 1.84974830 |
| 21 | PLK3 | 1.81642531 |
| 22 | NME2 | 1.80319353 |
| 23 | TYRO3 | 1.78689670 |
| 24 | TESK2 | 1.75089330 |
| 25 | RPS6KB2 | 1.73893401 |
| 26 | TRIM28 | 1.67657976 |
| 27 | CDC7 | 1.65049341 |
| 28 | TLK1 | 1.60200806 |
| 29 | PIM1 | 1.57117916 |
| 30 | EPHA2 | 1.56996138 |
| 31 | DYRK3 | 1.56472232 |
| 32 | PLK1 | 1.53974332 |
| 33 | CSK | 1.53500190 |
| 34 | YES1 | 1.50418758 |
| 35 | DYRK1B | 1.50308230 |
| 36 | OBSCN | 1.49313957 |
| 37 | ZAK | 1.49289687 |
| 38 | LATS2 | 1.49138738 |
| 39 | BCKDK | 1.43407701 |
| 40 | CDK12 | 1.43050466 |
| 41 | CHEK2 | 1.40071629 |
| 42 | ACVR1B | 1.37479515 |
| 43 | CDK19 | 1.36543616 |
| 44 | TSSK6 | 1.36185989 |
| 45 | PDGFRA | 1.29991615 |
| 46 | DAPK1 | 1.29922487 |
| 47 | NEK2 | 1.28975701 |
| 48 | CSNK1G3 | 1.26116527 |
| 49 | PDK2 | 1.26020046 |
| 50 | PRKD2 | 1.20265889 |
| 51 | ATR | 1.18024354 |
| 52 | TRPM7 | 1.16997242 |
| 53 | UHMK1 | 1.14987373 |
| 54 | CDK6 | 1.14959700 |
| 55 | EIF2AK3 | 1.13596439 |
| 56 | AKT3 | 1.12098559 |
| 57 | BCR | 1.10633659 |
| 58 | CSNK1G1 | 1.09940774 |
| 59 | CSNK1A1L | 1.08380837 |
| 60 | SRPK1 | 1.06781755 |
| 61 | TTK | 0.99699432 |
| 62 | TESK1 | 0.94989838 |
| 63 | RPS6KL1 | 0.93895576 |
| 64 | RPS6KC1 | 0.93895576 |
| 65 | NEK1 | 0.93747382 |
| 66 | AURKB | 0.93170577 |
| 67 | EPHB2 | 0.92769697 |
| 68 | CSNK1G2 | 0.91322028 |
| 69 | AURKA | 0.89172461 |
| 70 | MYLK | 0.89121371 |
| 71 | CCNB1 | 0.88043934 |
| 72 | STK10 | 0.87002351 |
| 73 | TAOK2 | 0.85969951 |
| 74 | MAP2K7 | 0.85491633 |
| 75 | MAP3K10 | 0.83754371 |
| 76 | RPS6KA6 | 0.82448895 |
| 77 | PBK | 0.81468600 |
| 78 | ERBB3 | 0.80563628 |
| 79 | WNK3 | 0.79536955 |
| 80 | MAPK11 | 0.79353665 |
| 81 | PAK4 | 0.78375041 |
| 82 | CHEK1 | 0.76866715 |
| 83 | PLK4 | 0.75929715 |
| 84 | BRSK2 | 0.72803541 |
| 85 | MAPKAPK3 | 0.72444357 |
| 86 | CSNK2A1 | 0.71094499 |
| 87 | MAP3K8 | 0.70621994 |
| 88 | STK3 | 0.69426202 |
| 89 | GRK7 | 0.68941672 |
| 90 | STK38L | 0.67881449 |
| 91 | MTOR | 0.67635683 |
| 92 | CDC42BPA | 0.67594697 |
| 93 | CDK2 | 0.67572627 |
| 94 | DYRK2 | 0.65634626 |
| 95 | TIE1 | 0.65413736 |
| 96 | CDK4 | 0.64944229 |
| 97 | PAK1 | 0.63107064 |
| 98 | RPS6KA1 | 0.61829680 |
| 99 | GSK3A | 0.60299625 |
| 100 | CSNK2A2 | 0.59919130 |
| 101 | RPS6KA4 | 0.59626905 |
| 102 | STK4 | 0.59607679 |
| 103 | ALK | 0.57391734 |
| 104 | ATM | 0.57200862 |
| 105 | BRSK1 | 0.56752822 |
| 106 | VRK1 | 0.55988724 |
| 107 | PASK | 0.55287825 |
| 108 | MOS | 0.54031388 |
| 109 | CDK8 | 0.53071919 |
| 110 | MKNK1 | 0.51200950 |
| 111 | ARAF | 0.49649693 |
| 112 | IKBKB | 0.49594677 |
| 113 | ABL2 | 0.49088716 |
| 114 | LRRK2 | 0.48751105 |
| 115 | DAPK3 | 0.48267873 |
| 116 | GRK1 | 0.48045312 |
| 117 | TNIK | 0.46030263 |
| 118 | FES | 0.44092927 |
| 119 | OXSR1 | 0.43694148 |
| 120 | ILK | 0.43608844 |
| 121 | MKNK2 | 0.43274225 |
| 122 | KDR | 0.41260165 |
| 123 | MAPKAPK2 | 0.39991138 |
| 124 | PLK2 | 0.39033087 |
| 125 | PAK2 | 0.39029663 |
| 126 | ADRBK2 | 0.38974982 |
| 127 | CDK14 | 0.38782759 |
| 128 | CDK1 | 0.36852734 |
| 129 | EPHB1 | 0.36007734 |
| 130 | MELK | 0.35678734 |
| 131 | LIMK1 | 0.35409746 |
| 132 | LATS1 | 0.35169601 |
| 133 | LYN | 0.34652566 |
| 134 | EGFR | 0.34201502 |
| 135 | PRKCI | 0.34079964 |
| 136 | CDK18 | 0.32506373 |
| 137 | MAPK1 | 0.31797399 |
| 138 | PRKG2 | 0.31598060 |
| 139 | CDK3 | 0.31404523 |
| 140 | NME1 | 0.31335482 |
| 141 | MAP4K1 | 0.31117702 |
| 142 | MAP4K2 | 0.29523086 |
| 143 | CDK11A | 0.29440074 |
| 144 | CSNK1A1 | 0.28701851 |
| 145 | PRKCG | 0.28620183 |
| 146 | CDK15 | 0.28493834 |
| 147 | RPS6KA5 | 0.28185562 |
| 148 | EIF2AK2 | 0.28035509 |
| 149 | MST4 | 0.27942083 |
| 150 | STK24 | 0.27701761 |
| 151 | PDK3 | 0.27590448 |
| 152 | BMPR1B | 0.26948281 |
| 153 | TYK2 | 0.25935882 |
| 154 | MAPKAPK5 | 0.23846532 |
| 155 | PHKG2 | 0.21900519 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mismatch repair_Homo sapiens_hsa03430 | 4.66283201 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.47998075 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.05221428 |
| 4 | Base excision repair_Homo sapiens_hsa03410 | 3.72727106 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.64004615 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.45781626 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.07272017 |
| 8 | Protein export_Homo sapiens_hsa03060 | 2.99940200 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.97318858 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.72847183 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.69943551 |
| 12 | * RNA transport_Homo sapiens_hsa03013 | 2.64685750 |
| 13 | RNA polymerase_Homo sapiens_hsa03020 | 2.52223226 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 2.31687714 |
| 15 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.13907214 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.09789452 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 2.07951262 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.05534010 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.02963099 |
| 20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.86450650 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.85782070 |
| 22 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.75472954 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.73446012 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.68930535 |
| 25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.67885762 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.64411690 |
| 27 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.60858240 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.58106377 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.44783859 |
| 30 | Sulfur relay system_Homo sapiens_hsa04122 | 1.36531171 |
| 31 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31659396 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28472841 |
| 33 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.27013197 |
| 34 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.26860155 |
| 35 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.26362236 |
| 36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.26265317 |
| 37 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.21999363 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.15130834 |
| 39 | RNA degradation_Homo sapiens_hsa03018 | 1.14324573 |
| 40 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.13954387 |
| 41 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13020811 |
| 42 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.09387852 |
| 43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.08656026 |
| 44 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.08597120 |
| 45 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.07016584 |
| 46 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.06688340 |
| 47 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.03814445 |
| 48 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.02447873 |
| 49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.98041702 |
| 50 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.97818359 |
| 51 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.96700254 |
| 52 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.94271373 |
| 53 | Shigellosis_Homo sapiens_hsa05131 | 0.91935114 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.91687293 |
| 55 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91299442 |
| 56 | Legionellosis_Homo sapiens_hsa05134 | 0.89868651 |
| 57 | Adherens junction_Homo sapiens_hsa04520 | 0.88552496 |
| 58 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.87448040 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.86424022 |
| 60 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.86152337 |
| 61 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.84785955 |
| 62 | Bladder cancer_Homo sapiens_hsa05219 | 0.84363556 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.84154913 |
| 64 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.83889224 |
| 65 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.80838643 |
| 66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.79852213 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.77972021 |
| 68 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.77163149 |
| 69 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.76557858 |
| 70 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.73594244 |
| 71 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.71316594 |
| 72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.68591951 |
| 73 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.68266020 |
| 74 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64218776 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.62575657 |
| 76 | HTLV-I infection_Homo sapiens_hsa05166 | 0.61661593 |
| 77 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.61090341 |
| 78 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61079146 |
| 79 | Purine metabolism_Homo sapiens_hsa00230 | 0.59860112 |
| 80 | Viral myocarditis_Homo sapiens_hsa05416 | 0.56585829 |
| 81 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55649444 |
| 82 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.54617967 |
| 83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.54087800 |
| 84 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.53257801 |
| 85 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.52362369 |
| 86 | Measles_Homo sapiens_hsa05162 | 0.51398218 |
| 87 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.50549393 |
| 88 | Huntingtons disease_Homo sapiens_hsa05016 | 0.50424181 |
| 89 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48661169 |
| 90 | Apoptosis_Homo sapiens_hsa04210 | 0.48098123 |
| 91 | * mTOR signaling pathway_Homo sapiens_hsa04150 | 0.47013685 |
| 92 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.45383206 |
| 93 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.45372099 |
| 94 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44498740 |
| 95 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.44251665 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44048132 |
| 97 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.41334132 |
| 98 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.40238636 |
| 99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.39765963 |
| 100 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.38632539 |
| 101 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.38264163 |
| 102 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.38146256 |
| 103 | Galactose metabolism_Homo sapiens_hsa00052 | 0.37716134 |
| 104 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.36937071 |
| 105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.36886884 |
| 106 | Tight junction_Homo sapiens_hsa04530 | 0.35615127 |
| 107 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.34988102 |
| 108 | Lysine degradation_Homo sapiens_hsa00310 | 0.34898606 |
| 109 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.34641654 |
| 110 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.34591470 |
| 111 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34541692 |
| 112 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.34098901 |
| 113 | Hepatitis B_Homo sapiens_hsa05161 | 0.34017204 |
| 114 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.32213788 |
| 115 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.31519786 |
| 116 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.31480368 |
| 117 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31012339 |
| 118 | Parkinsons disease_Homo sapiens_hsa05012 | 0.28967863 |
| 119 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.28875933 |
| 120 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.28590788 |
| 121 | Thyroid cancer_Homo sapiens_hsa05216 | 0.27995092 |
| 122 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.27933124 |
| 123 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.27808923 |
| 124 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27719876 |
| 125 | Pathways in cancer_Homo sapiens_hsa05200 | 0.26862058 |
| 126 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.26785542 |
| 127 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.26702412 |
| 128 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26639742 |
| 129 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.26018631 |
| 130 | Carbon metabolism_Homo sapiens_hsa01200 | 0.25958636 |
| 131 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.25109678 |
| 132 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.24922041 |
| 133 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.24406399 |
| 134 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.22584574 |
| 135 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.22567932 |
| 136 | Circadian rhythm_Homo sapiens_hsa04710 | 0.21915456 |
| 137 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.21441222 |
| 138 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.21170189 |
| 139 | * PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.18703757 |
| 140 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17545604 |
| 141 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.17392216 |
| 142 | Allograft rejection_Homo sapiens_hsa05330 | 0.16963062 |
| 143 | Prostate cancer_Homo sapiens_hsa05215 | 0.16257614 |
| 144 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.16109756 |
| 145 | Phototransduction_Homo sapiens_hsa04744 | 0.12298514 |
| 146 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.11839921 |
| 147 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.09517210 |

