EIF4E2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opsonization (GO:0008228)9.89002725
2regulation of interleukin-8 secretion (GO:2000482)9.29179529
3response to lead ion (GO:0010288)8.21017153
4limb bud formation (GO:0060174)7.76663048
5positive regulation of T cell differentiation in thymus (GO:0033089)7.44511451
6negative regulation of macrophage derived foam cell differentiation (GO:0010745)7.14903596
7negative regulation of mesenchymal cell apoptotic process (GO:2001054)7.01166532
8gonadal mesoderm development (GO:0007506)6.71316891
9somite development (GO:0061053)6.06451599
10embryonic foregut morphogenesis (GO:0048617)5.65381370
11positive regulation of meiosis (GO:0045836)5.60807826
12cell proliferation involved in metanephros development (GO:0072203)5.53332850
13negative regulation of smooth muscle cell differentiation (GO:0051151)5.50318320
14regulation of meiosis I (GO:0060631)5.48249966
15regulation of mesenchymal cell apoptotic process (GO:2001053)5.42433980
16artery development (GO:0060840)5.38841280
17negative regulation of lipid storage (GO:0010888)5.29341251
18CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.21119638
19positive regulation of meiotic cell cycle (GO:0051446)5.20115259
20negative regulation of axon guidance (GO:1902668)5.16132823
21positive regulation of glomerulus development (GO:0090193)5.02209480
22chondrocyte proliferation (GO:0035988)4.94983842
23lung lobe morphogenesis (GO:0060463)4.90554348
24regulation of cardiac muscle cell contraction (GO:0086004)4.56521158
25lymphoid progenitor cell differentiation (GO:0002320)4.51478295
26pantothenate metabolic process (GO:0015939)4.49381608
27lung epithelium development (GO:0060428)4.45855858
28prostate gland growth (GO:0060736)4.29510371
29negative regulation of leukocyte chemotaxis (GO:0002689)4.29289265
30male sex determination (GO:0030238)4.28432495
31negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.27850947
32proteasome assembly (GO:0043248)4.27826568
33negative regulation of alpha-beta T cell differentiation (GO:0046639)4.22560646
34regulation of transforming growth factor beta1 production (GO:0032908)4.20744045
35regulation of chronic inflammatory response (GO:0002676)4.15427424
36thalamus development (GO:0021794)4.10504783
37neuron projection extension involved in neuron projection guidance (GO:1902284)4.02028386
38axon extension involved in axon guidance (GO:0048846)4.02028386
39cell proliferation involved in kidney development (GO:0072111)4.00318308
40renal system development (GO:0072001)3.94970976
41regulation of cell proliferation involved in kidney development (GO:1901722)3.92205613
42positive regulation of male gonad development (GO:2000020)3.89520437
43regulation of chemokine-mediated signaling pathway (GO:0070099)3.81254387
44regulation of mesoderm development (GO:2000380)3.80097142
45regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.77429389
46regulation of T cell differentiation in thymus (GO:0033081)3.76133719
47T cell lineage commitment (GO:0002360)3.64374303
48transepithelial transport (GO:0070633)3.63807693
49lung-associated mesenchyme development (GO:0060484)3.63400957
50regulation of glomerulus development (GO:0090192)3.62438267
51negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.61389007
52dorsal/ventral neural tube patterning (GO:0021904)3.54775773
53negative regulation of DNA-templated transcription, elongation (GO:0032785)3.52617586
54regulation of smooth muscle cell differentiation (GO:0051150)3.49753995
55branch elongation of an epithelium (GO:0060602)3.44107974
56regulation of actin filament-based movement (GO:1903115)3.43200138
57regulation of axon guidance (GO:1902667)3.42851103
58regulation of male gonad development (GO:2000018)3.42657812
59hindbrain development (GO:0030902)3.40597646
60chronic inflammatory response (GO:0002544)3.34450913
61acute inflammatory response (GO:0002526)3.33832060
62positive regulation of calcium ion import (GO:0090280)3.33146843
63positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.28209021
64astrocyte differentiation (GO:0048708)3.21349057
65protein-cofactor linkage (GO:0018065)3.20582562
66branching involved in salivary gland morphogenesis (GO:0060445)3.19178019
67otic vesicle formation (GO:0030916)3.18394186
68negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.17336398
69DNA integration (GO:0015074)3.15529350
70mesenchymal cell proliferation (GO:0010463)3.14880696
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.14321066
72positive regulation of oligodendrocyte differentiation (GO:0048714)3.11708327
73cullin deneddylation (GO:0010388)3.11445113
74reproductive system development (GO:0061458)3.07881927
75water-soluble vitamin biosynthetic process (GO:0042364)3.03967559
76regulation of inflammatory response to antigenic stimulus (GO:0002861)2.99381494
77acute-phase response (GO:0006953)2.96801707
78protein K11-linked deubiquitination (GO:0035871)2.96552591
79regulation of macrophage derived foam cell differentiation (GO:0010743)2.96068736
80embryonic digestive tract morphogenesis (GO:0048557)2.94840764
81regulation of cellular extravasation (GO:0002691)2.92905027
82myotube differentiation (GO:0014902)2.92818943
83regulation of activin receptor signaling pathway (GO:0032925)2.92443646
84protein deneddylation (GO:0000338)2.89834794
85negative regulation of kidney development (GO:0090185)2.88781904
86negative chemotaxis (GO:0050919)2.88237398
87endothelial cell morphogenesis (GO:0001886)2.87497497
88male genitalia development (GO:0030539)2.87322253
89positive regulation of transforming growth factor beta production (GO:0071636)2.86853219
90regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.84998730
91regulation of mononuclear cell migration (GO:0071675)2.84407781
92pancreas development (GO:0031016)2.82355592
93Sertoli cell development (GO:0060009)2.77724449
94ectoderm development (GO:0007398)2.74393077
95negative thymic T cell selection (GO:0045060)2.71229849
96spinal cord motor neuron differentiation (GO:0021522)2.64866771
97negative T cell selection (GO:0043383)2.63151149
98chaperone-mediated protein transport (GO:0072321)2.63045152
99thyroid gland development (GO:0030878)2.61739186
100organ formation (GO:0048645)2.58065537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.25536988
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.97578301
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86661768
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84542677
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77865904
6IGF1R_20145208_ChIP-Seq_DFB_Human2.75106508
7VDR_22108803_ChIP-Seq_LS180_Human2.64933379
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63835035
9ZNF274_21170338_ChIP-Seq_K562_Hela2.62174411
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.54481670
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52189729
12EWS_26573619_Chip-Seq_HEK293_Human2.38841655
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.34158990
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.29931764
15AR_21572438_ChIP-Seq_LNCaP_Human2.21043780
16P300_19829295_ChIP-Seq_ESCs_Human2.20186618
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16789376
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.15851314
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.14646017
20GBX2_23144817_ChIP-Seq_PC3_Human2.02182806
21TAF15_26573619_Chip-Seq_HEK293_Human1.95253258
22FUS_26573619_Chip-Seq_HEK293_Human1.94597179
23BCAT_22108803_ChIP-Seq_LS180_Human1.93936401
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93014222
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82006803
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79744301
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76087713
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72864052
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69159067
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67843443
31NANOG_19829295_ChIP-Seq_ESCs_Human1.67745274
32SOX2_19829295_ChIP-Seq_ESCs_Human1.67745274
33ELK1_19687146_ChIP-ChIP_HELA_Human1.67296510
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62734343
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61877433
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.60017581
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.53385212
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.48359000
39CBP_20019798_ChIP-Seq_JUKART_Human1.45550256
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45550256
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43657219
42TCF4_22108803_ChIP-Seq_LS180_Human1.43624993
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.43233640
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42904676
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42507519
46SMAD4_21799915_ChIP-Seq_A2780_Human1.39131406
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39130767
48VDR_23849224_ChIP-Seq_CD4+_Human1.37103698
49ER_23166858_ChIP-Seq_MCF-7_Human1.35848535
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34863323
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.32204138
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31924384
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29794388
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.29494116
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29268744
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29217158
57STAT3_23295773_ChIP-Seq_U87_Human1.25850417
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24882349
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24251229
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24165287
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23624839
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23524690
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22596671
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21273352
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20526579
66SALL4_22934838_ChIP-ChIP_CD34+_Human1.18652731
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18006248
68TP53_16413492_ChIP-PET_HCT116_Human1.17554112
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17526734
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.16990263
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16468582
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16317081
73RUNX2_22187159_ChIP-Seq_PCA_Human1.15905909
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14261336
75P53_22387025_ChIP-Seq_ESCs_Mouse1.14201417
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.13786273
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11569627
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08705559
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.06383657
80PHF8_20622853_ChIP-Seq_HELA_Human1.06025766
81AR_25329375_ChIP-Seq_VCAP_Human1.04294719
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04208173
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03571564
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03563065
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.02281276
86AR_20517297_ChIP-Seq_VCAP_Human1.00841011
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.00770228
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99585947
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98306593
90EP300_21415370_ChIP-Seq_HL-1_Mouse0.97918019
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97460329
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97382982
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96726358
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96198241
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96055790
96RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95887198
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95700438
98HTT_18923047_ChIP-ChIP_STHdh_Human0.95543117
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95280233
100P300_18555785_Chip-Seq_ESCs_Mouse0.95255973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ8.24368468
2MP0002102_abnormal_ear_morphology5.15837814
3MP0003195_calcinosis4.72160738
4MP0002234_abnormal_pharynx_morphology4.14475323
5MP0009053_abnormal_anal_canal3.34511060
6MP0002138_abnormal_hepatobiliary_system3.20290780
7MP0002163_abnormal_gland_morphology2.95080147
8MP0000383_abnormal_hair_follicle2.72529335
9MP0000462_abnormal_digestive_system2.55443819
10MP0001873_stomach_inflammation2.37696948
11MP0002277_abnormal_respiratory_mucosa2.32499473
12MP0002282_abnormal_trachea_morphology2.19820062
13MP0010678_abnormal_skin_adnexa1.98911322
14MP0006054_spinal_hemorrhage1.98802263
15MP0004043_abnormal_pH_regulation1.91783585
16MP0010386_abnormal_urinary_bladder1.89575708
17MP0003806_abnormal_nucleotide_metabolis1.89527696
18MP0008058_abnormal_DNA_repair1.87062223
19MP0005171_absent_coat_pigmentation1.84699149
20MP0006292_abnormal_olfactory_placode1.84202928
21MP0002876_abnormal_thyroid_physiology1.76655635
22MP0002751_abnormal_autonomic_nervous1.74430843
23MP0001293_anophthalmia1.63337859
24MP0010368_abnormal_lymphatic_system1.63315318
25MP0003880_abnormal_central_pattern1.63008911
26MP0000613_abnormal_salivary_gland1.62928761
27MP0005084_abnormal_gallbladder_morpholo1.55129519
28MP0003252_abnormal_bile_duct1.54040823
29MP0003938_abnormal_ear_development1.53047602
30MP0004147_increased_porphyrin_level1.49640901
31MP0002928_abnormal_bile_duct1.38421110
32MP0005360_urolithiasis1.36279332
33MP0002233_abnormal_nose_morphology1.33339911
34MP0003950_abnormal_plasma_membrane1.32901472
35MP0003300_gastrointestinal_ulcer1.31484915
36MP0003646_muscle_fatigue1.31328149
37MP0001501_abnormal_sleep_pattern1.30953943
38MP0010030_abnormal_orbit_morphology1.29232961
39MP0005379_endocrine/exocrine_gland_phen1.27735835
40MP0008057_abnormal_DNA_replication1.26235672
41MP0003890_abnormal_embryonic-extraembry1.17955539
42MP0005365_abnormal_bile_salt1.14850922
43MP0000467_abnormal_esophagus_morphology1.12118645
44MP0000685_abnormal_immune_system1.12098813
45MP0009764_decreased_sensitivity_to1.11691759
46MP0009250_abnormal_appendicular_skeleto1.07186368
47MP0003119_abnormal_digestive_system1.05727655
48MP0003943_abnormal_hepatobiliary_system1.05383850
49MP0003937_abnormal_limbs/digits/tail_de1.04256860
50MP0004142_abnormal_muscle_tone1.01158795
51MP0002210_abnormal_sex_determination0.90293523
52MP0005410_abnormal_fertilization0.89592183
53MP0005253_abnormal_eye_physiology0.89499684
54MP0002736_abnormal_nociception_after0.89236396
55MP0001145_abnormal_male_reproductive0.89069042
56MP0000427_abnormal_hair_cycle0.87073953
57MP0008872_abnormal_physiological_respon0.86259538
58MP0009278_abnormal_bone_marrow0.85084567
59MP0001929_abnormal_gametogenesis0.84279523
60MP0005381_digestive/alimentary_phenotyp0.83065749
61MP0005220_abnormal_exocrine_pancreas0.82773327
62MP0001270_distended_abdomen0.82084326
63MP0005551_abnormal_eye_electrophysiolog0.81520653
64MP0000631_abnormal_neuroendocrine_gland0.81432078
65MP0003186_abnormal_redox_activity0.80652834
66MP0005423_abnormal_somatic_nervous0.79543586
67MP0002089_abnormal_postnatal_growth/wei0.78233239
68MP0000653_abnormal_sex_gland0.77944859
69MP0000538_abnormal_urinary_bladder0.76005891
70MP0005332_abnormal_amino_acid0.74901504
71MP0005085_abnormal_gallbladder_physiolo0.74217640
72MP0001119_abnormal_female_reproductive0.69676308
73MP0006035_abnormal_mitochondrial_morpho0.69671625
74MP0002095_abnormal_skin_pigmentation0.69112909
75MP0005671_abnormal_response_to0.68161443
76MP0001984_abnormal_olfaction0.66937975
77MP0000428_abnormal_craniofacial_morphol0.66344838
78MP0000026_abnormal_inner_ear0.66171575
79MP0001944_abnormal_pancreas_morphology0.65836403
80MP0001663_abnormal_digestive_system0.65529098
81MP0005408_hypopigmentation0.63882527
82MP0004272_abnormal_basement_membrane0.63555737
83MP0002132_abnormal_respiratory_system0.63155146
84MP0001764_abnormal_homeostasis0.61586447
85MP0001486_abnormal_startle_reflex0.61566721
86MP0002098_abnormal_vibrissa_morphology0.61311559
87MP0000049_abnormal_middle_ear0.60037982
88MP0001324_abnormal_eye_pigmentation0.59550048
89MP0006036_abnormal_mitochondrial_physio0.59428818
90MP0002938_white_spotting0.59159438
91MP0009785_altered_susceptibility_to0.58057870
92MP0001286_abnormal_eye_development0.56060225
93MP0001986_abnormal_taste_sensitivity0.53947873
94MP0001879_abnormal_lymphatic_vessel0.53716770
95MP0002254_reproductive_system_inflammat0.53053653
96MP0005310_abnormal_salivary_gland0.52222936
97MP0005174_abnormal_tail_pigmentation0.50190536
98MP0003698_abnormal_male_reproductive0.47840491
99MP0001485_abnormal_pinna_reflex0.47510809
100MP0003755_abnormal_palate_morphology0.46104922

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.63869936
2Dyschromatopsia (HP:0007641)4.13540890
3Abnormal number of incisors (HP:0011064)4.11078210
4True hermaphroditism (HP:0010459)3.66936184
5Acute necrotizing encephalopathy (HP:0006965)3.63495734
6Pancreatic cysts (HP:0001737)3.62622694
7Anophthalmia (HP:0000528)3.54773487
8Maternal diabetes (HP:0009800)3.41477885
9Abnormality of chromosome segregation (HP:0002916)3.35257461
10Central scotoma (HP:0000603)3.32558494
11Cerebral edema (HP:0002181)3.32071571
12Acute encephalopathy (HP:0006846)3.32053979
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.17607032
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.17607032
15Abnormality of the anterior horn cell (HP:0006802)3.15216692
16Degeneration of anterior horn cells (HP:0002398)3.15216692
17Oligodactyly (hands) (HP:0001180)3.14427834
18Progressive macrocephaly (HP:0004481)3.09523177
19Gonadotropin excess (HP:0000837)3.06354518
20Male pseudohermaphroditism (HP:0000037)3.02855980
2111 pairs of ribs (HP:0000878)2.98751032
22Abnormal mitochondria in muscle tissue (HP:0008316)2.96577033
23Ileus (HP:0002595)2.89087262
24Narrow nasal bridge (HP:0000446)2.88257421
25Colon cancer (HP:0003003)2.87843459
26Tented upper lip vermilion (HP:0010804)2.84030030
27Abnormality of the renal cortex (HP:0011035)2.71069501
28Tubular atrophy (HP:0000092)2.66996682
29Duodenal stenosis (HP:0100867)2.64263825
30Small intestinal stenosis (HP:0012848)2.64263825
31Abnormality of the corticospinal tract (HP:0002492)2.64085046
32Abnormal umbilical cord blood vessels (HP:0011403)2.61908303
33Single umbilical artery (HP:0001195)2.61908303
34Abnormality of the fetal cardiovascular system (HP:0010948)2.61908303
35Pancreatic fibrosis (HP:0100732)2.59732259
36Hyperglycinemia (HP:0002154)2.54560056
37Septo-optic dysplasia (HP:0100842)2.52812284
38Abnormality of the renal medulla (HP:0100957)2.52244246
39Abnormality of the duodenum (HP:0002246)2.47128179
40Triphalangeal thumb (HP:0001199)2.45524648
41Anosmia (HP:0000458)2.43635433
42Scotoma (HP:0000575)2.41168541
43Nephronophthisis (HP:0000090)2.38386740
44Porencephaly (HP:0002132)2.37697160
45Abnormality of midbrain morphology (HP:0002418)2.37384525
46Molar tooth sign on MRI (HP:0002419)2.37384525
47Tubulointerstitial abnormality (HP:0001969)2.37270132
48Tubulointerstitial nephritis (HP:0001970)2.36712279
49Rectal prolapse (HP:0002035)2.33428480
50Growth hormone deficiency (HP:0000824)2.31133338
51Horizontal nystagmus (HP:0000666)2.31113175
52Abnormal sex determination (HP:0012244)2.27709852
53Sex reversal (HP:0012245)2.27709852
54Spinal muscular atrophy (HP:0007269)2.20334815
55Postaxial foot polydactyly (HP:0001830)2.20267061
56Mitochondrial inheritance (HP:0001427)2.20206442
57Double outlet right ventricle (HP:0001719)2.19887813
58Congenital malformation of the right heart (HP:0011723)2.19887813
59Abolished electroretinogram (ERG) (HP:0000550)2.18851240
60Oligodactyly (HP:0012165)2.16876089
61Hyperglycinuria (HP:0003108)2.16410589
62Increased CSF lactate (HP:0002490)2.15466112
63Preaxial hand polydactyly (HP:0001177)2.12151786
64Hypoplasia of the uterus (HP:0000013)2.12106484
65Tubulointerstitial fibrosis (HP:0005576)2.11334814
66Abnormality of glycine metabolism (HP:0010895)2.10084798
67Abnormality of serine family amino acid metabolism (HP:0010894)2.10084798
68Preaxial foot polydactyly (HP:0001841)2.08029566
69Medial flaring of the eyebrow (HP:0010747)2.05022119
70Optic disc pallor (HP:0000543)2.04889970
71Gaze-evoked nystagmus (HP:0000640)2.01408147
72Abnormality of the fibula (HP:0002991)2.00624735
73Increased corneal curvature (HP:0100692)2.00516152
74Keratoconus (HP:0000563)2.00516152
75Exocrine pancreatic insufficiency (HP:0001738)1.98665806
76Congenital stationary night blindness (HP:0007642)1.96983755
77Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.95910640
78Vertebral hypoplasia (HP:0008417)1.95910640
79Pigmentary retinal degeneration (HP:0001146)1.95155605
80Methylmalonic acidemia (HP:0002912)1.93522427
81Hyperventilation (HP:0002883)1.92821424
82Vitreoretinal degeneration (HP:0000655)1.92719954
83Hypoplastic left heart (HP:0004383)1.92446704
84Abnormality of chromosome stability (HP:0003220)1.90647464
85Abnormality of the right ventricle (HP:0001707)1.86759841
86Methylmalonic aciduria (HP:0012120)1.85529627
87Chorioretinal atrophy (HP:0000533)1.84978678
88Aplasia/hypoplasia of the uterus (HP:0008684)1.84117363
89Choroideremia (HP:0001139)1.83434677
90Prenatal maternal abnormality (HP:0002686)1.82747773
91Hypothermia (HP:0002045)1.82361479
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.81937883
93Thyroiditis (HP:0100646)1.81191095
94Gonadal dysgenesis (HP:0000133)1.81175818
95Cystic liver disease (HP:0006706)1.80869168
96Hepatocellular necrosis (HP:0001404)1.80562944
97Abnormal biliary tract morphology (HP:0012440)1.80200745
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79083938
99Respiratory failure (HP:0002878)1.77592913
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76597112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.78685842
2STK393.83451903
3ACVR1B3.76589941
4TRIM283.68304331
5PNCK3.49930831
6CASK3.16521602
7PBK2.76845468
8TAF12.65652475
9INSRR2.55692127
10BMPR1B2.45166604
11FRK1.90986078
12MAPKAPK31.86528335
13OXSR11.85689258
14STK38L1.71309837
15VRK21.67265384
16ZAK1.64383510
17PIK3CA1.59739181
18BUB11.39170694
19TGFBR11.36855577
20PASK1.35088008
21PRKG21.28884204
22VRK11.25947310
23MAP3K41.25583290
24NME11.24527253
25MAP3K21.23550949
26EPHB21.22985911
27CSNK1G31.22373390
28WNK41.21780712
29BCKDK1.19219595
30TNIK1.18009856
31ARAF1.17119810
32CSNK1G21.14855736
33EPHA41.11222584
34GRK11.10116511
35TXK1.09788450
36CSNK1G11.02804685
37PLK31.01711203
38BCR0.95770781
39MAP3K130.94551637
40NEK90.94327198
41PTK2B0.90654672
42NUAK10.89832383
43SRPK10.88774492
44FLT30.88156757
45CSNK1A1L0.83291180
46BRSK20.81282961
47DAPK10.78028795
48TAOK30.73517747
49TSSK60.73022697
50ERBB30.72842673
51WNK30.70608303
52MKNK10.69787160
53CAMK1G0.68088610
54STK240.66719865
55PRKCQ0.66639595
56TTK0.63174973
57ROCK10.62461265
58FGFR10.58440009
59EIF2AK30.58312748
60MELK0.56505358
61CDK190.56465975
62STK30.55371288
63KSR10.54531087
64NTRK30.54043411
65NLK0.52776754
66FGFR20.52737213
67CCNB10.51449753
68CDK90.50742891
69MARK30.49601119
70TIE10.48382674
71MARK10.43354741
72MKNK20.42522536
73BRAF0.41798622
74FER0.41432521
75EIF2AK10.41190510
76MAP3K90.40007996
77NEK60.38640351
78PRKG10.38566778
79RAF10.38249822
80BRSK10.36893158
81ADRBK20.35957249
82IGF1R0.35523421
83PRKCE0.34343879
84PKN20.34232516
85GRK50.33059160
86PRKCG0.33024553
87ATR0.28998119
88CLK10.28655553
89PAK30.27695410
90KSR20.26742667
91CDK80.26270404
92ATM0.26138582
93PLK10.25842864
94TEC0.25734860
95CSNK2A10.24432513
96CHUK0.23208840
97CHEK20.22390548
98DYRK20.21284096
99ADRBK10.19679697
100TYRO30.19396856

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.33963991
2Protein export_Homo sapiens_hsa030603.21223433
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.14585303
4Proteasome_Homo sapiens_hsa030502.85860048
5Basal transcription factors_Homo sapiens_hsa030222.51828320
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41204032
7Fatty acid elongation_Homo sapiens_hsa000622.28019557
8Butanoate metabolism_Homo sapiens_hsa006502.20840812
9Basal cell carcinoma_Homo sapiens_hsa052172.00071053
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88765089
11Folate biosynthesis_Homo sapiens_hsa007901.87525129
12Vitamin B6 metabolism_Homo sapiens_hsa007501.87114305
13Glutathione metabolism_Homo sapiens_hsa004801.85060256
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81567303
15Tryptophan metabolism_Homo sapiens_hsa003801.78419246
16Hedgehog signaling pathway_Homo sapiens_hsa043401.77161261
17RNA polymerase_Homo sapiens_hsa030201.76542609
18Oxidative phosphorylation_Homo sapiens_hsa001901.76071100
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74396436
20Parkinsons disease_Homo sapiens_hsa050121.73314617
21Huntingtons disease_Homo sapiens_hsa050161.64111175
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.61888729
23Thyroid hormone synthesis_Homo sapiens_hsa049181.58905619
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54691513
25Fatty acid degradation_Homo sapiens_hsa000711.45424473
26Regulation of autophagy_Homo sapiens_hsa041401.43836977
27Mismatch repair_Homo sapiens_hsa034301.42293880
28RNA degradation_Homo sapiens_hsa030181.41682702
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38791083
30Fanconi anemia pathway_Homo sapiens_hsa034601.34030669
31Homologous recombination_Homo sapiens_hsa034401.32660977
32Non-homologous end-joining_Homo sapiens_hsa034501.30080052
33African trypanosomiasis_Homo sapiens_hsa051431.27280862
34Peroxisome_Homo sapiens_hsa041461.26323333
35Ribosome_Homo sapiens_hsa030101.25075390
36Fatty acid metabolism_Homo sapiens_hsa012121.20653097
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20437148
38Caffeine metabolism_Homo sapiens_hsa002321.18198835
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11351760
40Histidine metabolism_Homo sapiens_hsa003401.10696318
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08729441
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08655142
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08432730
44Phototransduction_Homo sapiens_hsa047441.01916136
45Arachidonic acid metabolism_Homo sapiens_hsa005901.00001934
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97406581
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95969972
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95534048
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94295931
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93557241
51RNA transport_Homo sapiens_hsa030130.92749178
52ABC transporters_Homo sapiens_hsa020100.92347386
53Nucleotide excision repair_Homo sapiens_hsa034200.92337917
54p53 signaling pathway_Homo sapiens_hsa041150.88141977
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84091930
56beta-Alanine metabolism_Homo sapiens_hsa004100.83924068
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83704985
58Linoleic acid metabolism_Homo sapiens_hsa005910.80615321
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80603931
60DNA replication_Homo sapiens_hsa030300.78145231
61Alzheimers disease_Homo sapiens_hsa050100.77971632
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.77621939
63Pancreatic secretion_Homo sapiens_hsa049720.75837619
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74670822
65Nicotine addiction_Homo sapiens_hsa050330.73720727
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.73384863
67Asthma_Homo sapiens_hsa053100.73158765
68Vibrio cholerae infection_Homo sapiens_hsa051100.72440655
69Chemical carcinogenesis_Homo sapiens_hsa052040.71999018
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70426524
71Pyruvate metabolism_Homo sapiens_hsa006200.68101271
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67323294
73Retinol metabolism_Homo sapiens_hsa008300.62020093
74Tight junction_Homo sapiens_hsa045300.61429665
75Sulfur metabolism_Homo sapiens_hsa009200.59871181
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59861460
77Malaria_Homo sapiens_hsa051440.59353705
78Hematopoietic cell lineage_Homo sapiens_hsa046400.54912910
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52548500
80Morphine addiction_Homo sapiens_hsa050320.52450668
81Vitamin digestion and absorption_Homo sapiens_hsa049770.46715638
82Purine metabolism_Homo sapiens_hsa002300.46446493
83Cocaine addiction_Homo sapiens_hsa050300.45568789
84Base excision repair_Homo sapiens_hsa034100.45126438
85GABAergic synapse_Homo sapiens_hsa047270.45016112
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43866821
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.43184321
88Bile secretion_Homo sapiens_hsa049760.41806113
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38446178
90Metabolic pathways_Homo sapiens_hsa011000.37003184
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36949264
92Complement and coagulation cascades_Homo sapiens_hsa046100.36573183
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35027355
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34598758
95Pyrimidine metabolism_Homo sapiens_hsa002400.34266710
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.33600163
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30164399
98TGF-beta signaling pathway_Homo sapiens_hsa043500.28867031
99Tyrosine metabolism_Homo sapiens_hsa003500.28856574
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28783081

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