EIF4E3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.42812998
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85899902
3negative regulation of execution phase of apoptosis (GO:1900118)4.61486918
4detection of molecule of bacterial origin (GO:0032490)4.44609042
5macrophage activation involved in immune response (GO:0002281)4.32244298
6activated T cell proliferation (GO:0050798)4.22473638
7microglial cell activation (GO:0001774)4.17496776
8detection of other organism (GO:0098543)4.11983764
9negative regulation of lymphocyte mediated immunity (GO:0002707)4.03952913
10regulation of gamma-delta T cell differentiation (GO:0045586)4.01895728
11mast cell activation (GO:0045576)3.96188430
12response to interleukin-15 (GO:0070672)3.88420807
13detection of external biotic stimulus (GO:0098581)3.86870799
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.81883213
15positive regulation of gamma-delta T cell activation (GO:0046645)3.81851787
16detection of bacterium (GO:0016045)3.69806202
17negative regulation of T cell mediated immunity (GO:0002710)3.68557197
18negative regulation of interleukin-12 production (GO:0032695)3.66837094
19negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.60650812
20regulation of RIG-I signaling pathway (GO:0039535)3.60021336
21macrophage activation (GO:0042116)3.60005309
22response to host immune response (GO:0052572)3.56474127
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56474127
24response to peptidoglycan (GO:0032494)3.55143758
25detection of biotic stimulus (GO:0009595)3.50503418
26regulation of meiosis (GO:0040020)3.49640973
27negative regulation of cAMP-mediated signaling (GO:0043951)3.47249415
28immunoglobulin mediated immune response (GO:0016064)3.46561217
29positive regulation of megakaryocyte differentiation (GO:0045654)3.45472643
30negative regulation of leukocyte mediated immunity (GO:0002704)3.43667870
31cellular response to interleukin-15 (GO:0071350)3.43091654
32heart contraction (GO:0060047)3.42927058
33heart process (GO:0003015)3.42927058
34female gamete generation (GO:0007292)3.40276316
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39994798
36negative regulation of T-helper cell differentiation (GO:0045623)3.39994798
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37011441
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37011441
39positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.36449814
40attachment of spindle microtubules to kinetochore (GO:0008608)3.31299894
41neutrophil mediated immunity (GO:0002446)3.29898409
42neutrophil activation (GO:0042119)3.29504271
43regulation of interferon-beta biosynthetic process (GO:0045357)3.24714937
44negative T cell selection (GO:0043383)3.24271509
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21074790
46response to host (GO:0075136)3.21074790
47response to host defenses (GO:0052200)3.21074790
48antigen processing and presentation of endogenous antigen (GO:0019883)3.20230356
49negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14319153
50regulation of relaxation of muscle (GO:1901077)3.13475422
51sequestering of actin monomers (GO:0042989)3.13303481
52myeloid cell activation involved in immune response (GO:0002275)3.13228132
53regulation of regulatory T cell differentiation (GO:0045589)3.11865921
54regulation of sequestering of triglyceride (GO:0010889)3.11682343
55negative thymic T cell selection (GO:0045060)3.08485267
56positive regulation of granulocyte differentiation (GO:0030854)3.08378516
57positive T cell selection (GO:0043368)3.07008405
58megakaryocyte development (GO:0035855)3.06774524
59leukocyte migration involved in inflammatory response (GO:0002523)3.06616176
60DNA damage induced protein phosphorylation (GO:0006975)3.06527088
61cellular response to zinc ion (GO:0071294)3.04762444
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.04615273
63myeloid leukocyte mediated immunity (GO:0002444)3.03652267
64myoblast migration (GO:0051451)3.02497241
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01540837
66regulation of steroid hormone secretion (GO:2000831)3.01445294
67interferon-gamma production (GO:0032609)3.00578147
68mast cell degranulation (GO:0043303)2.99652503
69mast cell activation involved in immune response (GO:0002279)2.99652503
70negative regulation of erythrocyte differentiation (GO:0045647)2.95874207
71antigen processing and presentation via MHC class Ib (GO:0002475)2.93602481
72B cell receptor signaling pathway (GO:0050853)2.92624611
73granulocyte activation (GO:0036230)2.92087173
74regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.91972880
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90264708
76negative regulation of immunoglobulin mediated immune response (GO:0002890)2.88779846
77negative regulation of B cell mediated immunity (GO:0002713)2.88779846
78histone H2A ubiquitination (GO:0033522)2.87487402
79negative regulation of adaptive immune response (GO:0002820)2.87271283
80interferon-gamma-mediated signaling pathway (GO:0060333)2.85585733
81regulation of natural killer cell mediated immunity (GO:0002715)2.83885950
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83885950
83positive thymic T cell selection (GO:0045059)2.82953332
84regulation of tolerance induction (GO:0002643)2.82419428
85centriole replication (GO:0007099)2.80519620
86detection of calcium ion (GO:0005513)2.79594833
87T cell migration (GO:0072678)2.79090794
88dendritic cell migration (GO:0036336)2.78656497
89positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76658135
90negative regulation of type 2 immune response (GO:0002829)2.75027619
91positive regulation of tolerance induction (GO:0002645)2.74762295
92type B pancreatic cell development (GO:0003323)2.74527790
93regulation of B cell receptor signaling pathway (GO:0050855)2.74395228
94positive regulation of defense response to virus by host (GO:0002230)2.72337150
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70846625
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70805508
97positive regulation of cellular amide metabolic process (GO:0034250)2.69528948
98regulation of meiotic cell cycle (GO:0051445)2.69173957
99T cell selection (GO:0045058)2.69133559
100piRNA metabolic process (GO:0034587)2.68949047
101cellular extravasation (GO:0045123)2.67569635
102signal peptide processing (GO:0006465)2.67414890
103negative regulation of homotypic cell-cell adhesion (GO:0034111)2.65198603
104germinal center formation (GO:0002467)2.64966076
105regulation of T cell tolerance induction (GO:0002664)2.64562625
106oxygen transport (GO:0015671)2.63547209
107regulation of granulocyte differentiation (GO:0030852)2.63292121
108respiratory burst (GO:0045730)2.62610086
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.62603136
110negative regulation of meiosis (GO:0045835)2.62115412
111response to type I interferon (GO:0034340)2.62000781
112negative regulation of meiotic cell cycle (GO:0051447)2.61855623
113cellular response to virus (GO:0098586)2.61436910
114type I interferon signaling pathway (GO:0060337)2.61327611
115cellular response to type I interferon (GO:0071357)2.61327611
116sarcoplasmic reticulum calcium ion transport (GO:0070296)2.61061620
117negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.59579366
118positive regulation of humoral immune response (GO:0002922)2.58905886
119tolerance induction (GO:0002507)2.58458273
120dendritic cell chemotaxis (GO:0002407)2.58398579
121positive regulation of macrophage differentiation (GO:0045651)2.57835252
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57192342
123positive regulation of B cell differentiation (GO:0045579)2.56005389
124hepatocyte apoptotic process (GO:0097284)2.55910084
125negative regulation of cell killing (GO:0031342)2.55705606
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55705606
127interkinetic nuclear migration (GO:0022027)2.55545441
128regulation of necroptotic process (GO:0060544)2.55001927
129regulation of T cell mediated cytotoxicity (GO:0001914)2.54869382
130myeloid dendritic cell activation (GO:0001773)2.53694720
131negative regulation of alpha-beta T cell activation (GO:0046636)2.52760270
132positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.52595499
133regulation of hypersensitivity (GO:0002883)2.51998411
134meiotic cell cycle (GO:0051321)2.51869135
135regulation of alpha-beta T cell proliferation (GO:0046640)2.51629286
136myeloid dendritic cell differentiation (GO:0043011)2.51509963
137cellular response to exogenous dsRNA (GO:0071360)2.51259546
138regulation of T-helper 2 cell differentiation (GO:0045628)2.50809480
139positive regulation of Cdc42 GTPase activity (GO:0043089)2.50440114
140production of molecular mediator involved in inflammatory response (GO:0002532)2.50256164
141regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49122234
142regulation of response to interferon-gamma (GO:0060330)2.44957752
143endothelium development (GO:0003158)2.44826411
144regulation of gamma-delta T cell activation (GO:0046643)2.43064203
145potassium ion export (GO:0071435)2.41161686
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39629292
147leukocyte aggregation (GO:0070486)2.37444046
148regulation of macrophage differentiation (GO:0045649)2.34250211
149phosphorelay signal transduction system (GO:0000160)2.34147741
150regulation of histone phosphorylation (GO:0033127)2.33251500
151negative regulation of granulocyte differentiation (GO:0030853)2.31387794
152positive regulation of T cell apoptotic process (GO:0070234)2.30259525
153microtubule nucleation (GO:0007020)2.29165026
154regulation of B cell differentiation (GO:0045577)2.28264990
155JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.28117606
156neutrophil activation involved in immune response (GO:0002283)2.27510105
157brown fat cell differentiation (GO:0050873)2.27181371
158modulation by virus of host process (GO:0019054)2.27169822
159barbed-end actin filament capping (GO:0051016)2.26427056
160regulation of histone H3-K27 methylation (GO:0061085)2.25933657
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.24791398
162positive regulation by organism of defense response of other organism involved in symbiotic interact2.24791398
163modulation by symbiont of host immune response (GO:0052553)2.24791398
164positive regulation by symbiont of host defense response (GO:0052509)2.24791398
165modulation by symbiont of host defense response (GO:0052031)2.24791398
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.24791398
167positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.24485049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.17472304
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58278814
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.41924680
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34151690
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.12296523
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.07793015
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.84494032
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78427752
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68812070
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60525230
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56279874
12EZH2_22144423_ChIP-Seq_EOC_Human2.45316555
13RUNX_20019798_ChIP-Seq_JUKART_Human2.40547040
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29997649
15SCL_19346495_ChIP-Seq_HPC-7_Human2.12725610
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12709161
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.06192663
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98957582
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96719317
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89816541
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89750194
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81851313
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81447276
24IGF1R_20145208_ChIP-Seq_DFB_Human1.63287629
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62419131
26MYB_26560356_Chip-Seq_TH2_Human1.61376850
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.60290262
28GATA3_27048872_Chip-Seq_THYMUS_Human1.60244436
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54682606
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54431405
31SPI1_23547873_ChIP-Seq_NB4_Human1.49192138
32* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48923464
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37500790
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37272055
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36756648
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34342417
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29659707
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28339443
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28189421
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27900955
41SPI1_23127762_ChIP-Seq_K562_Human1.26973175
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24187709
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.21547312
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20818528
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.20437255
46GATA1_22025678_ChIP-Seq_K562_Human1.18602571
47VDR_24787735_ChIP-Seq_THP-1_Human1.17461911
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17042418
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16776724
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.16580345
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15763659
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.15519603
53VDR_24763502_ChIP-Seq_THP-1_Human1.14213348
54* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14067032
55GATA3_26560356_Chip-Seq_TH2_Human1.13002004
56TAF15_26573619_Chip-Seq_HEK293_Human1.10362183
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10172141
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.09433736
59VDR_22108803_ChIP-Seq_LS180_Human1.08708814
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07826064
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.07549043
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05186553
63P300_19829295_ChIP-Seq_ESCs_Human1.04760417
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.04556538
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03982239
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03923057
67DROSHA_22980978_ChIP-Seq_HELA_Human1.03818108
68GATA2_19941826_ChIP-Seq_K562_Human1.03554973
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02400426
70KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02361788
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.00977128
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00421897
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00215975
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99673634
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98943429
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98034725
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97823719
78MAF_26560356_Chip-Seq_TH1_Human0.97467765
79FOXO3_23340844_ChIP-Seq_DLD1_Human0.95868533
80RUNX1_22412390_ChIP-Seq_EML_Mouse0.95861452
81GATA1_19941826_ChIP-Seq_K562_Human0.95705981
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95466440
83GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94791849
84ESR1_20079471_ChIP-ChIP_T-47D_Human0.94635043
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94066681
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93740390
87PU_27001747_Chip-Seq_BMDM_Mouse0.93640598
88MYB_26560356_Chip-Seq_TH1_Human0.93491649
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93390018
90SMRT_27268052_Chip-Seq_Bcells_Human0.92600066
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92498098
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90711979
93UTX_26944678_Chip-Seq_JUKART_Human0.90389590
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90280315
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89316516
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89176565
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88959756
98TCF7_22412390_ChIP-Seq_EML_Mouse0.88408662
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.86891155
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86829320
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86684846
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86170193
103* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85589758
104CTCF_18555785_Chip-Seq_ESCs_Mouse0.85565830
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85563213
106SOX2_18555785_Chip-Seq_ESCs_Mouse0.85385939
107NMYC_18555785_Chip-Seq_ESCs_Mouse0.84908305
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84607326
109P53_22387025_ChIP-Seq_ESCs_Mouse0.84552505
110OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84546619
111FLI1_21867929_ChIP-Seq_TH2_Mouse0.84256982
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83991591
113SMAD4_21799915_ChIP-Seq_A2780_Human0.83916982
114GBX2_23144817_ChIP-Seq_PC3_Human0.83897449
115GATA3_26560356_Chip-Seq_TH1_Human0.83148826
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82936334
117* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82608859
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82150325
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81571257
120KDM2B_26808549_Chip-Seq_REH_Human0.81174867
121* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80750591
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.80390833
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80366915
124TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80002477
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79992053
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79662796
127* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78381358
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78208087
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.77681354
130ER_23166858_ChIP-Seq_MCF-7_Human0.77109146
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74211599
132KDM2B_26808549_Chip-Seq_DND41_Human0.74141152
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.73559754
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73360994
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73270334
136GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73250825
137BCAT_22108803_ChIP-Seq_LS180_Human0.73152383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.64546781
2MP0002837_dystrophic_cardiac_calcinosis3.59741896
3MP0003303_peritoneal_inflammation3.21900637
4MP0003724_increased_susceptibility_to2.91704901
5MP0001835_abnormal_antigen_presentation2.91210176
6MP0005671_abnormal_response_to2.82971505
7MP0005670_abnormal_white_adipose2.73476993
8MP0009785_altered_susceptibility_to2.67127214
9MP0004510_myositis2.51728922
10MP0003763_abnormal_thymus_physiology2.42770584
11MP0010386_abnormal_urinary_bladder2.14856855
12MP0005000_abnormal_immune_tolerance2.00777372
13MP0004185_abnormal_adipocyte_glucose2.00080993
14MP0000569_abnormal_digit_pigmentation1.98089447
15MP0002148_abnormal_hypersensitivity_rea1.98089096
16MP0005451_abnormal_body_composition1.97652508
17MP0005310_abnormal_salivary_gland1.90564393
18MP0003172_abnormal_lysosome_physiology1.87687184
19MP0000343_altered_response_to1.85593838
20MP0000685_abnormal_immune_system1.85178157
21MP0004130_abnormal_muscle_cell1.82465924
22MP0005025_abnormal_response_to1.79442099
23MP0003300_gastrointestinal_ulcer1.77582490
24MP0003690_abnormal_glial_cell1.77197999
25MP0002419_abnormal_innate_immunity1.76670992
26MP0002420_abnormal_adaptive_immunity1.75404282
27MP0001800_abnormal_humoral_immune1.74830813
28MP0001819_abnormal_immune_cell1.74791477
29MP0001790_abnormal_immune_system1.74180168
30MP0005387_immune_system_phenotype1.74180168
31MP0002723_abnormal_immune_serum1.71381392
32MP0004215_abnormal_myocardial_fiber1.67333439
33MP0003436_decreased_susceptibility_to1.66971215
34MP0002452_abnormal_antigen_presenting1.65550384
35MP0000015_abnormal_ear_pigmentation1.61362997
36MP0000751_myopathy1.59666684
37MP0005409_darkened_coat_color1.57991148
38MP0008260_abnormal_autophagy1.54500100
39MP0002398_abnormal_bone_marrow1.54355633
40MP0002877_abnormal_melanocyte_morpholog1.53524903
41MP0006292_abnormal_olfactory_placode1.52671601
42MP0003866_abnormal_defecation1.47178016
43MP0002006_tumorigenesis1.42520966
44MP0001986_abnormal_taste_sensitivity1.40900798
45MP0000716_abnormal_immune_system1.40221285
46MP0004484_altered_response_of1.39477781
47MP0002405_respiratory_system_inflammati1.38466958
48MP0002106_abnormal_muscle_physiology1.38162489
49MP0004381_abnormal_hair_follicle1.37813891
50MP0004145_abnormal_muscle_electrophysio1.36577961
51MP0003828_pulmonary_edema1.35763651
52MP0005174_abnormal_tail_pigmentation1.34519930
53MP0008877_abnormal_DNA_methylation1.32841791
54MP0002693_abnormal_pancreas_physiology1.32279015
55MP0005666_abnormal_adipose_tissue1.31998377
56MP0002396_abnormal_hematopoietic_system1.31652771
57MP0005166_decreased_susceptibility_to1.30658591
58MP0002166_altered_tumor_susceptibility1.30503207
59MP0002277_abnormal_respiratory_mucosa1.29461038
60MP0004036_abnormal_muscle_relaxation1.28946079
61MP0003718_maternal_effect1.28218688
62MP0003075_altered_response_to1.28179700
63MP0000465_gastrointestinal_hemorrhage1.26750050
64MP0001984_abnormal_olfaction1.25296202
65MP0004883_abnormal_blood_vessel1.25250134
66MP0001501_abnormal_sleep_pattern1.24725957
67MP0001851_eye_inflammation1.24213485
68MP0002332_abnormal_exercise_endurance1.23363364
69MP0002933_joint_inflammation1.23299066
70MP0009333_abnormal_splenocyte_physiolog1.22929549
71MP0002971_abnormal_brown_adipose1.22186897
72MP0005464_abnormal_platelet_physiology1.20112251
73MP0008469_abnormal_protein_level1.18424782
74MP0005379_endocrine/exocrine_gland_phen1.18181016
75MP0000013_abnormal_adipose_tissue1.17656985
76MP0004947_skin_inflammation1.17647913
77MP0000749_muscle_degeneration1.16759438
78MP0003191_abnormal_cellular_cholesterol1.13338369
79MP0003656_abnormal_erythrocyte_physiolo1.11450419
80MP0003787_abnormal_imprinting1.10651685
81MP0002972_abnormal_cardiac_muscle1.09682436
82MP0000372_irregular_coat_pigmentation1.08813411
83MP0002132_abnormal_respiratory_system1.08547235
84MP0001905_abnormal_dopamine_level1.07998860
85MP0003183_abnormal_peptide_metabolism1.07880133
86MP0000689_abnormal_spleen_morphology1.06560320
87MP0002429_abnormal_blood_cell1.06329588
88MP0002638_abnormal_pupillary_reflex1.04327692
89MP0005620_abnormal_muscle_contractility1.03277147
90MP0001845_abnormal_inflammatory_respons1.03079949
91MP0002876_abnormal_thyroid_physiology1.02631959
92MP0006276_abnormal_autonomic_nervous1.01584533
93MP0002095_abnormal_skin_pigmentation1.01581381
94MP0009278_abnormal_bone_marrow1.01243008
95MP0005375_adipose_tissue_phenotype1.00889645
96MP0000703_abnormal_thymus_morphology1.00166265
97MP0001119_abnormal_female_reproductive0.99855656
98MP0010368_abnormal_lymphatic_system0.99754398
99MP0006082_CNS_inflammation0.99702662
100MP0003045_fibrosis0.99436831
101MP0000003_abnormal_adipose_tissue0.99136158
102MP0002998_abnormal_bone_remodeling0.99124374
103MP0001545_abnormal_hematopoietic_system0.98456083
104MP0005397_hematopoietic_system_phenotyp0.98456083
105MP0004808_abnormal_hematopoietic_stem0.97879205
106MP0001529_abnormal_vocalization0.97218496
107MP0002722_abnormal_immune_system0.94861139
108MP0001544_abnormal_cardiovascular_syste0.93707184
109MP0005385_cardiovascular_system_phenoty0.93707184
110MP0001533_abnormal_skeleton_physiology0.93163140
111MP0001853_heart_inflammation0.91581811
112MP0010155_abnormal_intestine_physiology0.91373153
113MP0005075_abnormal_melanosome_morpholog0.91360366
114MP0005369_muscle_phenotype0.89950909
115MP0005646_abnormal_pituitary_gland0.89365840
116MP0009115_abnormal_fat_cell0.89283277
117MP0004084_abnormal_cardiac_muscle0.89200479
118MP0006036_abnormal_mitochondrial_physio0.88773902
119MP0002102_abnormal_ear_morphology0.87053507
120MP0009764_decreased_sensitivity_to0.86949918
121MP0005164_abnormal_response_to0.86337666
122MP0004087_abnormal_muscle_fiber0.82902788
123MP0005535_abnormal_body_temperature0.82447756
124MP0008874_decreased_physiological_sensi0.80753378
125MP0003699_abnormal_female_reproductive0.80667604
126MP0005330_cardiomyopathy0.80445653
127MP0008057_abnormal_DNA_replication0.80054026
128MP0002009_preneoplasia0.79136953
129MP0003221_abnormal_cardiomyocyte_apopto0.78322968
130MP0000858_altered_metastatic_potential0.71965345
131MP0000604_amyloidosis0.70934340
132MP0001663_abnormal_digestive_system0.70410043
133MP0002078_abnormal_glucose_homeostasis0.64916944
134MP0004043_abnormal_pH_regulation0.64111024
135MP0003448_altered_tumor_morphology0.62939913
136MP0000920_abnormal_myelination0.61613949
137MP0001765_abnormal_ion_homeostasis0.61495922
138MP0008569_lethality_at_weaning0.60946535
139MP0003633_abnormal_nervous_system0.57469926
140MP0009763_increased_sensitivity_to0.57209886

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.49219283
2Recurrent abscess formation (HP:0002722)4.20282943
3Optic neuritis (HP:0100653)3.78810582
4Retrobulbar optic neuritis (HP:0100654)3.78810582
5Recurrent bacterial skin infections (HP:0005406)3.76037883
6Hypothermia (HP:0002045)3.62655503
7Thyroiditis (HP:0100646)3.48068703
8Male infertility (HP:0003251)3.45178007
9Orchitis (HP:0100796)3.40750849
10Severe combined immunodeficiency (HP:0004430)3.19042467
11Insulin-resistant diabetes mellitus (HP:0000831)3.17415220
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.17140070
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04394437
14Abnormality of alanine metabolism (HP:0010916)3.04394437
15Hyperalaninemia (HP:0003348)3.04394437
16Gingivitis (HP:0000230)2.98013637
17Combined immunodeficiency (HP:0005387)2.97521400
18Elevated erythrocyte sedimentation rate (HP:0003565)2.95081752
19Eczematoid dermatitis (HP:0000976)2.89198240
20Recurrent fungal infections (HP:0002841)2.84488953
21Keratoconjunctivitis sicca (HP:0001097)2.82637824
22Prolonged bleeding time (HP:0003010)2.77766967
23Hypochromic microcytic anemia (HP:0004840)2.76267598
24Abnormality of T cells (HP:0002843)2.74235319
25Gingival bleeding (HP:0000225)2.72486514
26Difficulty running (HP:0009046)2.70653640
27Panhypogammaglobulinemia (HP:0003139)2.69760566
28Spondylolisthesis (HP:0003302)2.69376368
29Atrial fibrillation (HP:0005110)2.68947000
30Recurrent viral infections (HP:0004429)2.66797877
31Recurrent skin infections (HP:0001581)2.62615417
32Papilledema (HP:0001085)2.61668384
33Episodic fever (HP:0001954)2.55423946
34Pulmonary embolism (HP:0002204)2.55316593
35Leukocytosis (HP:0001974)2.53997546
36Urticaria (HP:0001025)2.50822653
37Primary atrial arrhythmia (HP:0001692)2.50698477
38Keratoconjunctivitis (HP:0001096)2.50439881
39Oligomenorrhea (HP:0000876)2.49355344
40Abnormality of the left ventricular outflow tract (HP:0011103)2.48438671
41Subaortic stenosis (HP:0001682)2.48438671
42Meningitis (HP:0001287)2.47930980
43Abnormality of eosinophils (HP:0001879)2.45559024
44Muscle fiber inclusion bodies (HP:0100299)2.44817491
45Pulmonary infiltrates (HP:0002113)2.42204480
46Calf muscle hypertrophy (HP:0008981)2.39292829
47Hyporeflexia of lower limbs (HP:0002600)2.38649389
48Supraventricular tachycardia (HP:0004755)2.37884193
49Exertional dyspnea (HP:0002875)2.37440308
50Muscle hypertrophy of the lower extremities (HP:0008968)2.36723952
51Sudden death (HP:0001699)2.35188765
52Thrombocytosis (HP:0001894)2.35032713
53Lipoatrophy (HP:0100578)2.34848945
54Anorexia (HP:0002039)2.34281195
55Vasculitis (HP:0002633)2.33175548
56Arterial thrombosis (HP:0004420)2.31751294
57Inflammation of the large intestine (HP:0002037)2.31020749
58Papillary thyroid carcinoma (HP:0002895)2.30590569
59Chronic mucocutaneous candidiasis (HP:0002728)2.30324437
60Recurrent cutaneous fungal infections (HP:0011370)2.30324437
61Nemaline bodies (HP:0003798)2.30079887
62Supraventricular arrhythmia (HP:0005115)2.29221984
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.25782878
64Ventricular tachycardia (HP:0004756)2.25555689
65Abnormality of the endocardium (HP:0004306)2.25187840
66Hemiplegia (HP:0002301)2.24291992
67Abnormal hair whorl (HP:0010721)2.23679713
68Type 2 muscle fiber atrophy (HP:0003554)2.22985479
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22768330
70B lymphocytopenia (HP:0010976)2.22403191
71Abnormality of B cell number (HP:0010975)2.22403191
72Muscle fiber splitting (HP:0003555)2.21544239
73Hepatic necrosis (HP:0002605)2.21397777
74Hematochezia (HP:0002573)2.19589758
75Recurrent bronchitis (HP:0002837)2.18360756
76Abnormality of the fingertips (HP:0001211)2.18070607
77Tinnitus (HP:0000360)2.18038413
78Acute myeloid leukemia (HP:0004808)2.17786787
79Ventricular fibrillation (HP:0001663)2.16939656
80Increased muscle lipid content (HP:0009058)2.16001962
81Spontaneous hematomas (HP:0007420)2.15385421
82Eosinophilia (HP:0001880)2.15384542
83Exercise-induced myalgia (HP:0003738)2.15330630
84Amyloidosis (HP:0011034)2.14893619
85Abnormality of macrophages (HP:0004311)2.14803750
86Hypochromic anemia (HP:0001931)2.14174607
87Nonprogressive disorder (HP:0003680)2.12362663
88Abnormality of lateral ventricle (HP:0030047)2.10869279
89Gastrointestinal infarctions (HP:0005244)2.10480457
90Gastrointestinal inflammation (HP:0004386)2.10273687
91Slow saccadic eye movements (HP:0000514)2.09031295
92Abnormality of midbrain morphology (HP:0002418)2.08878453
93Molar tooth sign on MRI (HP:0002419)2.08878453
94Agammaglobulinemia (HP:0004432)2.08504929
95Abnormality of the fovea (HP:0000493)2.07653428
96Vacuolated lymphocytes (HP:0001922)2.06656412
97Epistaxis (HP:0000421)2.06537951
98Neoplasm of the tracheobronchial system (HP:0100552)2.05674810
99Increased IgE level (HP:0003212)2.04881504
100Gangrene (HP:0100758)2.02792147
101Palpitations (HP:0001962)2.02345837
102Myoglobinuria (HP:0002913)2.01076742
103Hypoplasia of the thymus (HP:0000778)2.00908091
104Hemoptysis (HP:0002105)2.00837037
105Recurrent gram-negative bacterial infections (HP:0005420)2.00319756
106Muscle fiber atrophy (HP:0100295)2.00114453
107Acne (HP:0001061)1.99392507
108Postural instability (HP:0002172)1.98502940
109Stomach cancer (HP:0012126)1.98418195
110Chronic diarrhea (HP:0002028)1.97423785
111Peritonitis (HP:0002586)1.95237039
112Increased CSF protein (HP:0002922)1.95222047
113Gastrointestinal stroma tumor (HP:0100723)1.94824250
114Autoimmune hemolytic anemia (HP:0001890)1.94631339
115Cerebral hemorrhage (HP:0001342)1.94010818
116Hypoplasia of the fovea (HP:0007750)1.93907262
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.93907262
118T lymphocytopenia (HP:0005403)1.93901177
119Left ventricular hypertrophy (HP:0001712)1.92959860
120Pulmonary fibrosis (HP:0002206)1.92641637
121Syncope (HP:0001279)1.92142956
122Generalized aminoaciduria (HP:0002909)1.91932933
123Granulocytopenia (HP:0001913)1.91473004
124Abnormality of T cell number (HP:0011839)1.91405495
125Abnormality of the pleura (HP:0002103)1.91308125
126Hepatocellular necrosis (HP:0001404)1.91227040
127Febrile seizures (HP:0002373)1.90937838
128Microcytic anemia (HP:0001935)1.90193051
129IgM deficiency (HP:0002850)1.90045283
130Encephalitis (HP:0002383)1.89144185
131Obstructive lung disease (HP:0006536)1.88378257
132Chronic obstructive pulmonary disease (HP:0006510)1.88378257
133EMG: myopathic abnormalities (HP:0003458)1.88348507
134Osteomyelitis (HP:0002754)1.87983161
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87934320
136Easy fatigability (HP:0003388)1.87150828
137Capillary hemangiomas (HP:0005306)1.86681840
138Chest pain (HP:0100749)1.84127229
139Arterial tortuosity (HP:0005116)1.83987258
140Abnormality of T cell physiology (HP:0011840)1.83604519
141Hypoproteinemia (HP:0003075)1.83244736
142Stomatitis (HP:0010280)1.82992934
143Mediastinal lymphadenopathy (HP:0100721)1.82909507
144Alveolar cell carcinoma (HP:0006519)1.82314313
145Lipid accumulation in hepatocytes (HP:0006561)1.82044516
146Vertigo (HP:0002321)1.81285717
147Frequent falls (HP:0002359)1.81148231
148Acute hepatic failure (HP:0006554)1.80922756
149Cellulitis (HP:0100658)1.80458681
150Sepsis (HP:0100806)1.76527459
151Pustule (HP:0200039)1.76057466
152Increased IgM level (HP:0003496)1.75946510
153Joint swelling (HP:0001386)1.74941306
154Polyneuropathy (HP:0001271)1.71007168
155Toxemia of pregnancy (HP:0100603)1.67577225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.91336971
2TAOK34.83035409
3MAP3K63.84520508
4MOS2.91689143
5MUSK2.61952206
6IRAK42.47798835
7TXK2.46047992
8RIPK42.18705609
9CSK2.17537958
10MAP4K12.14571096
11ARAF2.01953519
12KIT2.01683754
13NLK1.95046548
14PRPF4B1.93193541
15MAP3K131.91357387
16CDK91.83505610
17PLK41.81768476
18CDK81.78346174
19TIE11.76540078
20GRK61.74491788
21TEC1.69852871
22FRK1.69478241
23ZAP701.68401731
24DMPK1.62112353
25JAK31.62006888
26MAP3K21.54319550
27RAF11.51885234
28EPHB11.49553870
29BRAF1.47479705
30LATS11.46302741
31TNK21.45126864
32HIPK21.42302158
33FGFR31.36649322
34DAPK21.32710525
35KSR21.27532028
36IKBKE1.27127077
37BTK1.26872418
38INSRR1.24252360
39MAP3K121.21148035
40PRKD21.20537199
41NEK91.19408230
42FGR1.18339021
43TYK21.15484032
44CAMKK21.14268991
45ACVR1B1.12275437
46SGK31.12268472
47TNIK1.08625338
48TBK11.06991934
49MAP3K31.04524736
50MAP2K61.04225544
51STK241.03349943
52SYK1.01671111
53STK111.01669421
54PINK11.00904617
55EPHA31.00791533
56MAP2K30.99627086
57MAPK120.96540019
58RIPK10.95291679
59MAPK130.94874238
60MAPKAPK50.94210825
61NUAK10.93293749
62MAPKAPK30.92461612
63PRKAA20.91515143
64EEF2K0.90063591
65GRK70.89916410
66TTN0.88677491
67PDK10.88400955
68TAOK10.87982253
69STK100.87869797
70MAP3K70.87278849
71ADRBK20.87270393
72TRPM70.86465177
73NTRK30.85179630
74MAP3K10.85043995
75CAMKK10.84643008
76KSR10.81802150
77CDK190.81112058
78MARK30.80968895
79SGK4940.79998748
80SGK2230.79998748
81ITK0.79883403
82CSNK1G10.79604370
83MAPK70.79074075
84ERN10.76528734
85CDK30.75763255
86MAP3K140.74119812
87MAP3K50.73694896
88PIM20.73625050
89TGFBR20.73225347
90MYLK0.71415516
91MAP2K40.70752223
92PTK2B0.70270228
93LCK0.69938178
94ERBB40.69646428
95JAK10.69307195
96GRK50.68778991
97CAMK40.68090593
98WNK10.67583601
99IRAK10.67485853
100PRKD30.64631126
101RET0.64373736
102STK380.63562639
103SGK10.63091555
104PAK30.62060174
105STK38L0.61561447
106BMPR1B0.60747274
107BLK0.60010361
108PIK3CA0.60010141
109SIK30.59189765
110OXSR10.58735782
111IRAK30.58693364
112PDPK10.57494266
113ABL10.57269624
114HCK0.56835096
115IRAK20.56725227
116CAMK10.56657017
117FYN0.55769402
118PHKG10.55556994
119PHKG20.55556994
120LYN0.55412508
121CAMK1G0.55243160
122MAP3K110.52809843
123CAMK1D0.52214134
124MAPK110.51791717
125OBSCN0.51718108
126MAP2K70.51435578
127MATK0.50788639
128FES0.49356583
129TTK0.46948954
130FGFR40.46363213
131PIK3CG0.46025526
132CHUK0.45840132
133PRKAA10.45757732
134STK30.45503801
135JAK20.45105967
136KDR0.44797470
137CSNK1G30.44235981
138LATS20.43148654
139PRKCQ0.42854486
140MARK20.42631761
141IKBKB0.42020086
142DYRK20.41141707
143YES10.39986241
144CSF1R0.36250986
145CSNK1G20.35699886
146ABL20.34590209
147SGK20.34133888

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.33371534
2Protein export_Homo sapiens_hsa030602.13626856
3Other glycan degradation_Homo sapiens_hsa005111.97019050
4Ovarian steroidogenesis_Homo sapiens_hsa049131.95624959
5Leishmaniasis_Homo sapiens_hsa051401.94278335
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91131457
7Staphylococcus aureus infection_Homo sapiens_hsa051501.90888183
8Circadian rhythm_Homo sapiens_hsa047101.79776576
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64933932
10RNA degradation_Homo sapiens_hsa030181.59538535
11Jak-STAT signaling pathway_Homo sapiens_hsa046301.55270726
12Osteoclast differentiation_Homo sapiens_hsa043801.54353732
13Hematopoietic cell lineage_Homo sapiens_hsa046401.54261797
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.53409197
15Non-homologous end-joining_Homo sapiens_hsa034501.51342134
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.47349174
17Pancreatic cancer_Homo sapiens_hsa052121.45216023
18Measles_Homo sapiens_hsa051621.38985896
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37177214
20Long-term potentiation_Homo sapiens_hsa047201.36080013
21Graft-versus-host disease_Homo sapiens_hsa053321.35168235
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34566149
23Olfactory transduction_Homo sapiens_hsa047401.29740322
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25934359
25Allograft rejection_Homo sapiens_hsa053301.22536638
26Malaria_Homo sapiens_hsa051441.21604802
27B cell receptor signaling pathway_Homo sapiens_hsa046621.19664661
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18602400
29Legionellosis_Homo sapiens_hsa051341.17498970
30Toxoplasmosis_Homo sapiens_hsa051451.17127009
31Viral myocarditis_Homo sapiens_hsa054161.16235477
32Prolactin signaling pathway_Homo sapiens_hsa049171.16002974
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14477555
34Chemokine signaling pathway_Homo sapiens_hsa040621.13916331
35Basal transcription factors_Homo sapiens_hsa030221.12741695
36Non-small cell lung cancer_Homo sapiens_hsa052231.11148664
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11043796
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10694952
39Tuberculosis_Homo sapiens_hsa051521.08756227
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08467203
41T cell receptor signaling pathway_Homo sapiens_hsa046601.08175588
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03760990
43Herpes simplex infection_Homo sapiens_hsa051681.02202887
44Pertussis_Homo sapiens_hsa051331.02083612
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00642634
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00501853
47Asthma_Homo sapiens_hsa053101.00381435
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98474978
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94736345
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94097356
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92638019
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92313272
53Platelet activation_Homo sapiens_hsa046110.91760254
54Hepatitis C_Homo sapiens_hsa051600.91423854
55African trypanosomiasis_Homo sapiens_hsa051430.90749490
56Sphingolipid metabolism_Homo sapiens_hsa006000.90127122
57Ether lipid metabolism_Homo sapiens_hsa005650.90043713
58Influenza A_Homo sapiens_hsa051640.89932531
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.88803666
60Hepatitis B_Homo sapiens_hsa051610.87837643
61Shigellosis_Homo sapiens_hsa051310.87208640
62Serotonergic synapse_Homo sapiens_hsa047260.85782661
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85134271
64Inositol phosphate metabolism_Homo sapiens_hsa005620.84461238
65Type II diabetes mellitus_Homo sapiens_hsa049300.83739463
66Thyroid cancer_Homo sapiens_hsa052160.82784203
67Cell cycle_Homo sapiens_hsa041100.81780533
68Rheumatoid arthritis_Homo sapiens_hsa053230.81111113
69Long-term depression_Homo sapiens_hsa047300.81108020
70Dilated cardiomyopathy_Homo sapiens_hsa054140.80875793
71Oxytocin signaling pathway_Homo sapiens_hsa049210.80681067
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80459703
73Antigen processing and presentation_Homo sapiens_hsa046120.80456746
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79974999
75VEGF signaling pathway_Homo sapiens_hsa043700.79489925
76Regulation of autophagy_Homo sapiens_hsa041400.78678662
77Amphetamine addiction_Homo sapiens_hsa050310.78578877
78Acute myeloid leukemia_Homo sapiens_hsa052210.77831965
79Homologous recombination_Homo sapiens_hsa034400.74483587
80TNF signaling pathway_Homo sapiens_hsa046680.72252054
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72250649
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.72058181
83Chronic myeloid leukemia_Homo sapiens_hsa052200.71531497
84Endometrial cancer_Homo sapiens_hsa052130.71422391
85Autoimmune thyroid disease_Homo sapiens_hsa053200.71417326
86cAMP signaling pathway_Homo sapiens_hsa040240.70263117
87Gastric acid secretion_Homo sapiens_hsa049710.68775796
88Linoleic acid metabolism_Homo sapiens_hsa005910.67890018
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67622319
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.67609300
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67197836
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.67197327
93Circadian entrainment_Homo sapiens_hsa047130.67172249
94GnRH signaling pathway_Homo sapiens_hsa049120.67166202
95mTOR signaling pathway_Homo sapiens_hsa041500.66773293
96Type I diabetes mellitus_Homo sapiens_hsa049400.66771018
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66573061
98Salmonella infection_Homo sapiens_hsa051320.66054596
99Dorso-ventral axis formation_Homo sapiens_hsa043200.65235527
100Ras signaling pathway_Homo sapiens_hsa040140.65108865
101FoxO signaling pathway_Homo sapiens_hsa040680.64385762
102Pancreatic secretion_Homo sapiens_hsa049720.64199723
103Morphine addiction_Homo sapiens_hsa050320.63219639
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.61921854
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.61770637
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61687609
107Colorectal cancer_Homo sapiens_hsa052100.61195883
108Estrogen signaling pathway_Homo sapiens_hsa049150.58834247
109Alzheimers disease_Homo sapiens_hsa050100.58362705
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57761176
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57467869
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57081378
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56570129
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56504257
115Apoptosis_Homo sapiens_hsa042100.56259729
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56030193
117Dopaminergic synapse_Homo sapiens_hsa047280.55827542
118Insulin secretion_Homo sapiens_hsa049110.55739506
119Renin secretion_Homo sapiens_hsa049240.55356618
120Insulin resistance_Homo sapiens_hsa049310.54278787
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.54063478
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53446456
123Glioma_Homo sapiens_hsa052140.52893518
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52685418
125Cholinergic synapse_Homo sapiens_hsa047250.52240127
126Salivary secretion_Homo sapiens_hsa049700.52053345
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.51042891
128Parkinsons disease_Homo sapiens_hsa050120.49523541
129Oxidative phosphorylation_Homo sapiens_hsa001900.48534458
130Insulin signaling pathway_Homo sapiens_hsa049100.48451722
131MAPK signaling pathway_Homo sapiens_hsa040100.47577772
132Taste transduction_Homo sapiens_hsa047420.46307295
133Phagosome_Homo sapiens_hsa041450.45977346
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.45854195
135Renal cell carcinoma_Homo sapiens_hsa052110.45780106
136Choline metabolism in cancer_Homo sapiens_hsa052310.44934326
137Arachidonic acid metabolism_Homo sapiens_hsa005900.44103065

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