EIF4EBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)4.84310388
2L-serine metabolic process (GO:0006563)4.83553334
3maturation of SSU-rRNA (GO:0030490)4.81275404
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76847988
5DNA deamination (GO:0045006)4.74482433
6ribosomal small subunit assembly (GO:0000028)4.54948650
7formation of translation preinitiation complex (GO:0001731)4.53021696
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.30486869
9DNA replication initiation (GO:0006270)4.27606748
10protein maturation by protein folding (GO:0022417)4.27310875
11ribosome assembly (GO:0042255)4.22649582
12proteasome assembly (GO:0043248)4.21114155
13ribosomal large subunit biogenesis (GO:0042273)4.20237855
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.18506943
15ATP synthesis coupled proton transport (GO:0015986)4.18506943
16DNA strand elongation involved in DNA replication (GO:0006271)4.18110997
17nucleobase biosynthetic process (GO:0046112)4.16287407
18ribosomal small subunit biogenesis (GO:0042274)4.15006452
19ribosome biogenesis (GO:0042254)4.14386518
20ribonucleoprotein complex biogenesis (GO:0022613)4.10109599
21viral transcription (GO:0019083)4.07826485
22translational termination (GO:0006415)4.03798929
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02365788
24protein targeting to mitochondrion (GO:0006626)4.01332430
25telomere maintenance via semi-conservative replication (GO:0032201)3.98615419
26DNA strand elongation (GO:0022616)3.97714686
27purine nucleobase biosynthetic process (GO:0009113)3.95717472
28folic acid-containing compound biosynthetic process (GO:0009396)3.86843959
29IMP biosynthetic process (GO:0006188)3.85118229
30establishment of viral latency (GO:0019043)3.83583827
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72809018
32translational elongation (GO:0006414)3.71883959
33regulation of posttranscriptional gene silencing (GO:0060147)3.68842136
34regulation of gene silencing by miRNA (GO:0060964)3.68842136
35regulation of gene silencing by RNA (GO:0060966)3.68842136
36DNA replication checkpoint (GO:0000076)3.67599963
37establishment of protein localization to mitochondrion (GO:0072655)3.67455838
38* translational initiation (GO:0006413)3.66874439
39rRNA modification (GO:0000154)3.65456456
40mitotic metaphase plate congression (GO:0007080)3.61275961
41oxidative phosphorylation (GO:0006119)3.60170660
42regulation of cellular amino acid metabolic process (GO:0006521)3.57949476
43pseudouridine synthesis (GO:0001522)3.55307711
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.54166335
45rRNA processing (GO:0006364)3.52724040
46respiratory electron transport chain (GO:0022904)3.51459153
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.50518361
48protein localization to mitochondrion (GO:0070585)3.50505389
49guanosine-containing compound biosynthetic process (GO:1901070)3.49162480
50telomere maintenance via recombination (GO:0000722)3.48464810
51regulation of translational fidelity (GO:0006450)3.47663785
52UTP biosynthetic process (GO:0006228)3.46419879
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46233697
54GTP biosynthetic process (GO:0006183)3.45153871
55spliceosomal snRNP assembly (GO:0000387)3.44518956
56electron transport chain (GO:0022900)3.41891270
57mitotic nuclear envelope disassembly (GO:0007077)3.40255411
58rRNA metabolic process (GO:0016072)3.39876357
59DNA unwinding involved in DNA replication (GO:0006268)3.38700823
60protein complex biogenesis (GO:0070271)3.38087980
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37946881
62DNA replication-dependent nucleosome assembly (GO:0006335)3.36596924
63DNA replication-dependent nucleosome organization (GO:0034723)3.36596924
64IMP metabolic process (GO:0046040)3.35044271
65telomere maintenance via telomere lengthening (GO:0010833)3.33945572
66mitochondrial respiratory chain complex assembly (GO:0033108)3.32050779
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31626329
68pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.31210317
69CTP metabolic process (GO:0046036)3.29421984
70CTP biosynthetic process (GO:0006241)3.29421984
71peptidyl-histidine modification (GO:0018202)3.28009255
72serine family amino acid biosynthetic process (GO:0009070)3.27401931
73protein targeting to ER (GO:0045047)3.26881109
74maturation of 5.8S rRNA (GO:0000460)3.26159600
75cotranslational protein targeting to membrane (GO:0006613)3.26101070
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25767962
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24992911
78* translation (GO:0006412)3.24035349
79chromatin remodeling at centromere (GO:0031055)3.19443678
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.19040790
81NADH dehydrogenase complex assembly (GO:0010257)3.19040790
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19040790
83CENP-A containing nucleosome assembly (GO:0034080)3.18269986
84positive regulation of ligase activity (GO:0051351)3.17935610
85mitotic recombination (GO:0006312)3.17920703
86termination of RNA polymerase III transcription (GO:0006386)3.17192212
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.17192212
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16787195
89protein localization to kinetochore (GO:0034501)3.16398621
90UTP metabolic process (GO:0046051)3.16378502
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16309841
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.15842802
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14013930
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13830947
95regulation of ubiquitin-protein transferase activity (GO:0051438)3.13244993
96folic acid metabolic process (GO:0046655)3.12777094
97transcription-coupled nucleotide-excision repair (GO:0006283)3.12106981
98viral life cycle (GO:0019058)3.12084875
99cellular protein complex disassembly (GO:0043624)3.11709444
100pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.09875069
101kinetochore assembly (GO:0051382)3.09240220
102nuclear envelope disassembly (GO:0051081)3.08919557
103membrane disassembly (GO:0030397)3.08919557
104cellular component biogenesis (GO:0044085)3.08521168
105establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08107997
106protein localization to endoplasmic reticulum (GO:0070972)3.05991879
107establishment of integrated proviral latency (GO:0075713)3.02385152
108kinetochore organization (GO:0051383)3.01444112
109transcription from RNA polymerase I promoter (GO:0006360)3.01279002
110metaphase plate congression (GO:0051310)2.99642249
111nuclear pore organization (GO:0006999)2.98983206
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98865823
113negative regulation of ligase activity (GO:0051352)2.98865823
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95927495
115nucleotide-excision repair, DNA gap filling (GO:0006297)2.95351446
116regulation of mitochondrial translation (GO:0070129)2.93955875
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93009072
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93009072
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93009072
120termination of RNA polymerase I transcription (GO:0006363)2.92674161
121tRNA aminoacylation for protein translation (GO:0006418)2.92527892
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.91913893
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91913893
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91248728
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91248728
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.86750102
127regulation of helicase activity (GO:0051095)2.86432977
128nucleobase-containing small molecule interconversion (GO:0015949)2.86404297
129L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86204630
130* G1/S transition of mitotic cell cycle (GO:0000082)2.84434330
131* cell cycle G1/S phase transition (GO:0044843)2.84434330
132amino acid activation (GO:0043038)2.84103341
133tRNA aminoacylation (GO:0043039)2.84103341
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.83611182
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83611182
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82785142
137DNA replication-independent nucleosome assembly (GO:0006336)2.81852233
138DNA replication-independent nucleosome organization (GO:0034724)2.81852233
139protein K6-linked ubiquitination (GO:0085020)2.81450532
140spliceosomal complex assembly (GO:0000245)2.80807549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64110112
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.57765958
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67894524
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24129797
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14457473
6* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98860265
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98714659
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.96039338
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92822902
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.90689485
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86777841
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.79872044
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.76187061
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57272388
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57199448
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40420580
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34677687
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33257603
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25316601
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23575816
21XRN2_22483619_ChIP-Seq_HELA_Human2.22093739
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22031802
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09446280
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04761164
25VDR_23849224_ChIP-Seq_CD4+_Human2.03725208
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97661461
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96134429
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96134429
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96134429
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93753231
31* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89376490
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85497121
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85292442
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84966112
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81623992
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75464411
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75190712
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74313969
39GABP_19822575_ChIP-Seq_HepG2_Human1.74214978
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74074893
41TTF2_22483619_ChIP-Seq_HELA_Human1.72204764
42FOXP3_21729870_ChIP-Seq_TREG_Human1.72180169
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.68975520
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67577997
45AR_21909140_ChIP-Seq_LNCAP_Human1.61003934
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57869824
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55630384
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.53635407
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52456191
50ZNF263_19887448_ChIP-Seq_K562_Human1.52228988
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52112241
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.51955470
53ELK1_19687146_ChIP-ChIP_HELA_Human1.50853458
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46782816
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46635714
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45782431
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45257560
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41048927
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39452100
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38118601
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34164755
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33866814
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33054058
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.32399407
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.30932337
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29999910
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27788813
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25474226
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23848131
70TFEB_21752829_ChIP-Seq_HELA_Human1.23031806
71CIITA_25753668_ChIP-Seq_RAJI_Human1.21922975
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21029009
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20995304
74SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19766598
75KDM5A_27292631_Chip-Seq_BREAST_Human1.16193088
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15853270
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15375386
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12073136
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10290010
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09894292
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09420937
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.09109416
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08905562
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08852554
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08831351
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.08082326
87* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07820748
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07694090
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.07575371
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07131740
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07117489
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04842121
93MYC_18940864_ChIP-ChIP_HL60_Human1.04766511
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.03998951
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03976227
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.03299610
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.00388702
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00264822
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99463737
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98760157
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98377291
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97713247
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95771321
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95587494
105VDR_21846776_ChIP-Seq_THP-1_Human0.95579108
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95480196
107MYC_22102868_ChIP-Seq_BL_Human0.94606029
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93930818
109* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93838192
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92639943
111* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92450766
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90974150
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89464020
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89440773
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89029687
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88807841
117SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84641521
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84154797
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83761249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.84612473
2MP0004957_abnormal_blastocyst_morpholog4.03572181
3MP0003111_abnormal_nucleus_morphology3.92125804
4MP0010094_abnormal_chromosome_stability3.48285865
5MP0003077_abnormal_cell_cycle3.35461442
6MP0003806_abnormal_nucleotide_metabolis3.13191802
7MP0008057_abnormal_DNA_replication2.80454978
8MP0008058_abnormal_DNA_repair2.76843427
9MP0008932_abnormal_embryonic_tissue2.48479574
10MP0008007_abnormal_cellular_replicative2.45772191
11MP0010352_gastrointestinal_tract_polyps2.18335206
12MP0001730_embryonic_growth_arrest1.99726025
13MP0003786_premature_aging1.97961917
14MP0003123_paternal_imprinting1.92472913
15MP0003186_abnormal_redox_activity1.91507782
16MP0004133_heterotaxia1.89504810
17MP0000350_abnormal_cell_proliferation1.87768479
18MP0003941_abnormal_skin_development1.83245207
19MP0003718_maternal_effect1.82538976
20MP0000372_irregular_coat_pigmentation1.79884405
21MP0010030_abnormal_orbit_morphology1.73849269
22MP0001672_abnormal_embryogenesis/_devel1.68422254
23MP0005380_embryogenesis_phenotype1.68422254
24MP0002254_reproductive_system_inflammat1.67874703
25MP0009697_abnormal_copulation1.66179131
26MP0008438_abnormal_cutaneous_collagen1.63306380
27MP0000750_abnormal_muscle_regeneration1.63009970
28MP0003567_abnormal_fetal_cardiomyocyte1.59965057
29MP0003984_embryonic_growth_retardation1.52077871
30MP0001697_abnormal_embryo_size1.50994164
31MP0002938_white_spotting1.49910280
32MP0002088_abnormal_embryonic_growth/wei1.48879717
33MP0000490_abnormal_crypts_of1.47905981
34MP0002396_abnormal_hematopoietic_system1.47238113
35MP0004233_abnormal_muscle_weight1.45100693
36MP0010307_abnormal_tumor_latency1.43568623
37MP0002080_prenatal_lethality1.42164163
38MP0003566_abnormal_cell_adhesion1.39505583
39MP0002085_abnormal_embryonic_tissue1.39349118
40MP0004197_abnormal_fetal_growth/weight/1.39158894
41MP0002086_abnormal_extraembryonic_tissu1.33170906
42MP0005023_abnormal_wound_healing1.31944018
43MP0003705_abnormal_hypodermis_morpholog1.24879320
44MP0000858_altered_metastatic_potential1.24382862
45MP0000313_abnormal_cell_death1.23956709
46MP0002084_abnormal_developmental_patter1.22502354
47MP0001661_extended_life_span1.21364770
48MP0003315_abnormal_perineum_morphology1.21173851
49MP0003119_abnormal_digestive_system1.17339806
50MP0002163_abnormal_gland_morphology1.15290894
51MP0002019_abnormal_tumor_incidence1.14486569
52MP0004272_abnormal_basement_membrane1.14475579
53MP0005408_hypopigmentation1.14443500
54MP0002877_abnormal_melanocyte_morpholog1.11274505
55MP0001764_abnormal_homeostasis1.11043856
56MP0009672_abnormal_birth_weight1.10351658
57MP0004084_abnormal_cardiac_muscle1.08344196
58MP0001293_anophthalmia1.08307773
59MP0001881_abnormal_mammary_gland1.07852613
60MP0005451_abnormal_body_composition1.04974326
61MP0000678_abnormal_parathyroid_gland1.04405568
62MP0002796_impaired_skin_barrier1.03747297
63MP0002111_abnormal_tail_morphology1.03440607
64MP0002160_abnormal_reproductive_system1.02908353
65MP0005075_abnormal_melanosome_morpholog1.00420216
66MP0000537_abnormal_urethra_morphology0.99810240
67MP0000358_abnormal_cell_content/0.98807716
68MP0003136_yellow_coat_color0.98542594
69MP0003890_abnormal_embryonic-extraembry0.98441999
70MP0002132_abnormal_respiratory_system0.97292585
71MP0009333_abnormal_splenocyte_physiolog0.96518650
72MP0001545_abnormal_hematopoietic_system0.93832076
73MP0005397_hematopoietic_system_phenotyp0.93832076
74MP0003221_abnormal_cardiomyocyte_apopto0.92358524
75MP0006036_abnormal_mitochondrial_physio0.89853027
76MP0006292_abnormal_olfactory_placode0.89385482
77MP0002269_muscular_atrophy0.88852859
78MP0005266_abnormal_metabolism0.88152775
79MP0005389_reproductive_system_phenotype0.86482014
80MP0008789_abnormal_olfactory_epithelium0.85605566
81MP0002060_abnormal_skin_morphology0.85310898
82MP0002210_abnormal_sex_determination0.85099393
83MP0001542_abnormal_bone_strength0.82686885
84MP0008877_abnormal_DNA_methylation0.82625780
85MP0002234_abnormal_pharynx_morphology0.82130535
86MP0001853_heart_inflammation0.81519031
87MP0003828_pulmonary_edema0.81382180
88MP0002653_abnormal_ependyma_morphology0.81295238
89MP0005257_abnormal_intraocular_pressure0.80197085
90MP0008995_early_reproductive_senescence0.80095812
91MP0005501_abnormal_skin_physiology0.79701294
92MP0005330_cardiomyopathy0.78825552
93MP0001145_abnormal_male_reproductive0.78609687
94MP0006035_abnormal_mitochondrial_morpho0.78542103
95MP0000516_abnormal_urinary_system0.76410069
96MP0005367_renal/urinary_system_phenotyp0.76410069
97MP0003950_abnormal_plasma_membrane0.75594868
98MP0004808_abnormal_hematopoietic_stem0.74967594
99MP0005275_abnormal_skin_tensile0.74305467
100MP0002697_abnormal_eye_size0.73637841
101MP0005076_abnormal_cell_differentiation0.73423655
102MP0001188_hyperpigmentation0.73151663
103MP0000467_abnormal_esophagus_morphology0.72945716
104MP0005395_other_phenotype0.72514617
105MP0004858_abnormal_nervous_system0.71770685
106MP0003279_aneurysm0.71297677
107MP0000749_muscle_degeneration0.70322816
108* MP0005384_cellular_phenotype0.69674590
109MP0000762_abnormal_tongue_morphology0.68051968
110MP0000343_altered_response_to0.67185318
111MP0004185_abnormal_adipocyte_glucose0.67010965
112MP0005083_abnormal_biliary_tract0.66595227
113MP0001915_intracranial_hemorrhage0.66540626
114MP0001727_abnormal_embryo_implantation0.66431404
115MP0006054_spinal_hemorrhage0.65948096
116MP0002127_abnormal_cardiovascular_syste0.65712529
117MP0005332_abnormal_amino_acid0.65367136
118MP0000653_abnormal_sex_gland0.65119013
119MP0001286_abnormal_eye_development0.64748232
120MP0009379_abnormal_foot_pigmentation0.64705322
121MP0000733_abnormal_muscle_development0.64402141
122MP0003646_muscle_fatigue0.63810154
123MP0003448_altered_tumor_morphology0.63447244
124MP0009053_abnormal_anal_canal0.63080121
125MP0005636_abnormal_mineral_homeostasis0.62846884
126* MP0005621_abnormal_cell_physiology0.62447807
127MP0001919_abnormal_reproductive_system0.61967137
128MP0005623_abnormal_meninges_morphology0.61158744
129MP0003937_abnormal_limbs/digits/tail_de0.61069490
130MP0008873_increased_physiological_sensi0.60992815
131MP0002277_abnormal_respiratory_mucosa0.60305955
132MP0000049_abnormal_middle_ear0.59254951
133MP0005084_abnormal_gallbladder_morpholo0.59058545
134MP0001849_ear_inflammation0.59057346
135MP0001119_abnormal_female_reproductive0.58541288
136MP0003936_abnormal_reproductive_system0.58487614
137MP0000432_abnormal_head_morphology0.57970628
138MP0001929_abnormal_gametogenesis0.57392842
139MP0010771_integument_phenotype0.56945485

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.15596013
2Abnormal mitochondria in muscle tissue (HP:0008316)5.02296792
3Birth length less than 3rd percentile (HP:0003561)4.84603663
4Acute encephalopathy (HP:0006846)4.79551675
5Breast hypoplasia (HP:0003187)4.51448959
6Mitochondrial inheritance (HP:0001427)4.50623647
7Hepatocellular necrosis (HP:0001404)4.46292810
8Reticulocytopenia (HP:0001896)4.28917345
9Increased CSF lactate (HP:0002490)4.22092621
10Hepatic necrosis (HP:0002605)4.01685371
11Progressive macrocephaly (HP:0004481)3.98087418
12Abnormality of cells of the erythroid lineage (HP:0012130)3.81110748
13Carpal bone hypoplasia (HP:0001498)3.75976120
14Cerebral edema (HP:0002181)3.61453693
15Abnormal number of erythroid precursors (HP:0012131)3.50710948
16Lipid accumulation in hepatocytes (HP:0006561)3.31652012
17Rough bone trabeculation (HP:0100670)3.31193479
18Increased hepatocellular lipid droplets (HP:0006565)3.30202902
19Oral leukoplakia (HP:0002745)3.27616249
20Abnormality of glycolysis (HP:0004366)3.25825312
21Lactic acidosis (HP:0003128)3.25490864
22Selective tooth agenesis (HP:0001592)3.24283406
23Trismus (HP:0000211)3.23574264
24Increased serum pyruvate (HP:0003542)3.19616182
25Absent radius (HP:0003974)3.14211201
26Increased intramyocellular lipid droplets (HP:0012240)3.05951195
27Exercise intolerance (HP:0003546)3.05409590
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04279985
29Chromsome breakage (HP:0040012)3.02275132
30Multiple enchondromatosis (HP:0005701)2.97798483
31Absent thumb (HP:0009777)2.96005389
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.94361214
33Abnormal protein N-linked glycosylation (HP:0012347)2.94361214
34Abnormal protein glycosylation (HP:0012346)2.94361214
35Abnormal glycosylation (HP:0012345)2.94361214
36Respiratory failure (HP:0002878)2.93899210
37Aplasia involving forearm bones (HP:0009822)2.90865302
38Absent forearm bone (HP:0003953)2.90865302
39Abnormality of the anterior horn cell (HP:0006802)2.90223536
40Degeneration of anterior horn cells (HP:0002398)2.90223536
41Patellar aplasia (HP:0006443)2.88124354
42Increased muscle lipid content (HP:0009058)2.86937706
43Colon cancer (HP:0003003)2.85074533
44Reduced antithrombin III activity (HP:0001976)2.84422621
45Macrocytic anemia (HP:0001972)2.83571474
46Renal Fanconi syndrome (HP:0001994)2.82495977
47Meckel diverticulum (HP:0002245)2.75222351
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.75024273
49Aplasia/Hypoplasia of the patella (HP:0006498)2.72765711
50Ependymoma (HP:0002888)2.72180746
51Pallor (HP:0000980)2.67813626
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63643053
53Abnormality of the ileum (HP:0001549)2.59673820
54Abnormality of abdominal situs (HP:0011620)2.54169340
55Abdominal situs inversus (HP:0003363)2.54169340
56Aplasia/hypoplasia of the humerus (HP:0006507)2.53405336
57Breech presentation (HP:0001623)2.52970219
58Aplastic anemia (HP:0001915)2.52480612
59Abnormal trabecular bone morphology (HP:0100671)2.51843103
60Supernumerary spleens (HP:0009799)2.50823148
61Cerebral hypomyelination (HP:0006808)2.48800789
62Agnosia (HP:0010524)2.47728927
63Premature ovarian failure (HP:0008209)2.43103829
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42387750
65Premature graying of hair (HP:0002216)2.41818769
66Neoplasm of the pancreas (HP:0002894)2.38136749
67Abnormality of the preputium (HP:0100587)2.35683778
68Duplicated collecting system (HP:0000081)2.35241508
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34142714
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34142714
71Microvesicular hepatic steatosis (HP:0001414)2.31343211
72Ragged-red muscle fibers (HP:0003200)2.30590036
73Testicular atrophy (HP:0000029)2.30482379
74Respiratory difficulties (HP:0002880)2.24383858
75Medulloblastoma (HP:0002885)2.22131323
76Leukodystrophy (HP:0002415)2.21767611
77Nausea (HP:0002018)2.18268462
78Microretrognathia (HP:0000308)2.16323148
79Horseshoe kidney (HP:0000085)2.16216027
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.15359131
81Sparse eyelashes (HP:0000653)2.15152341
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14004609
83Redundant skin (HP:0001582)2.11851505
84Abnormalities of placenta or umbilical cord (HP:0001194)2.11596472
85Lethargy (HP:0001254)2.11482060
86Abnormality of chromosome stability (HP:0003220)2.10866408
87Secondary amenorrhea (HP:0000869)2.10798531
88Ureteral duplication (HP:0000073)2.09772535
89Patent foramen ovale (HP:0001655)2.07994009
90Exertional dyspnea (HP:0002875)2.07522533
91Progressive muscle weakness (HP:0003323)2.07365127
92Abnormality of pyrimidine metabolism (HP:0004353)2.06369591
93Abnormal gallbladder physiology (HP:0012438)2.05495559
94Cholecystitis (HP:0001082)2.05495559
95Bone marrow hypocellularity (HP:0005528)2.05185330
96Tracheoesophageal fistula (HP:0002575)2.02888494
97Triphalangeal thumb (HP:0001199)2.02608401
98Rib fusion (HP:0000902)2.01443315
99Impulsivity (HP:0100710)1.99910436
100Methylmalonic aciduria (HP:0012120)1.99698323
101Emotional lability (HP:0000712)1.99682516
102Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98995600
103Protrusio acetabuli (HP:0003179)1.98253932
104Increased serum lactate (HP:0002151)1.97203570
105CNS demyelination (HP:0007305)1.97082267
106Dicarboxylic aciduria (HP:0003215)1.96840806
107Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96840806
108Hyperglycinemia (HP:0002154)1.96173092
109Short humerus (HP:0005792)1.95791173
110Slender long bone (HP:0003100)1.94977923
111Abnormality of the umbilical cord (HP:0010881)1.93179490
112Abnormality of the renal collecting system (HP:0004742)1.90038229
113Myelodysplasia (HP:0002863)1.89518615
114Distal lower limb muscle weakness (HP:0009053)1.88437542
115Upper limb muscle weakness (HP:0003484)1.88178784
116Fused cervical vertebrae (HP:0002949)1.87583234
117Optic disc pallor (HP:0000543)1.87446461
118Duodenal stenosis (HP:0100867)1.86011582
119Small intestinal stenosis (HP:0012848)1.86011582
120Abnormality of serum amino acid levels (HP:0003112)1.85119012
121Rhabdomyosarcoma (HP:0002859)1.84026176
122Premature rupture of membranes (HP:0001788)1.83655242
123Breast aplasia (HP:0100783)1.81402492
124Rhabdomyolysis (HP:0003201)1.81013832
125Cleft eyelid (HP:0000625)1.80648712
126Death in infancy (HP:0001522)1.80410911
127Abnormality of placental membranes (HP:0011409)1.78607900
128Amniotic constriction ring (HP:0009775)1.78607900
129Long foot (HP:0001833)1.77072219
130Asplenia (HP:0001746)1.76901721
131Pancytopenia (HP:0001876)1.76885887
132Cellular immunodeficiency (HP:0005374)1.76628178
133Hypoplasia of the radius (HP:0002984)1.75704010
134Facial cleft (HP:0002006)1.75596675
135Abnormal umbilical cord blood vessels (HP:0011403)1.75377378
136Single umbilical artery (HP:0001195)1.75377378
137Abnormality of the fetal cardiovascular system (HP:0010948)1.75377378
138Atresia of the external auditory canal (HP:0000413)1.75186004
139Missing ribs (HP:0000921)1.75125418
140Type I transferrin isoform profile (HP:0003642)1.75024771
141Abnormality of reticulocytes (HP:0004312)1.74568326
142Abnormality of methionine metabolism (HP:0010901)1.73673899
143Generalized aminoaciduria (HP:0002909)1.73031933
144Poor head control (HP:0002421)1.73030447
1453-Methylglutaconic aciduria (HP:0003535)1.71514098
146Congenital, generalized hypertrichosis (HP:0004540)1.70702231
14711 pairs of ribs (HP:0000878)1.70463604
148Aplasia/Hypoplasia of the breasts (HP:0010311)1.70364146
149Abnormality of the labia minora (HP:0012880)1.69921628
150Rectal fistula (HP:0100590)1.69819920
151Rectovaginal fistula (HP:0000143)1.69819920
152Abnormality of alanine metabolism (HP:0010916)1.67825423
153Hyperalaninemia (HP:0003348)1.67825423
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67825423
155Hypoplasia of the pons (HP:0012110)1.67720141
156Opisthotonus (HP:0002179)1.65925387
157Spastic paraparesis (HP:0002313)1.60482263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.60466319
2BUB14.56498928
3WEE14.06326839
4EPHA23.44290137
5NME23.24307471
6EIF2AK13.04752426
7CDC72.44189557
8TTK2.36364642
9PLK42.34851381
10SRPK12.19341317
11STK162.08388398
12EIF2AK32.07787491
13ZAK2.05989912
14RPS6KB21.93586260
15NEK11.83530562
16PLK11.80122580
17TSSK61.78238312
18CDK71.77430954
19BCKDK1.76859003
20TESK21.74947668
21NEK21.72885873
22TLK11.69875330
23SMG11.67396110
24BRSK21.63892189
25PIM21.60583000
26STK38L1.58337763
27VRK11.53815008
28RPS6KA41.50077375
29MST41.49041745
30ARAF1.43505640
31AURKB1.41457987
32MAPKAPK31.38087231
33ACVR1B1.37974514
34DYRK31.36702454
35PAK41.35629650
36ATR1.33014209
37KDR1.31855057
38CDK121.30703931
39LATS21.30614867
40TAF11.29722802
41AURKA1.29480296
42IRAK31.22056503
43MAP3K111.20492242
44CHEK21.20043314
45MKNK11.19638172
46PLK31.19181666
47CSNK1G31.17747671
48DAPK11.17409638
49FLT31.12896814
50CDK41.10986789
51EIF2AK21.06562701
52STK41.01777807
53AKT31.01419077
54PASK1.01144148
55PIM10.99066977
56NUAK10.95976937
57CDK190.94250857
58TRIM280.92148709
59TAOK20.91966662
60MAP3K120.91780569
61STK100.89460418
62TGFBR10.88773727
63NME10.87194682
64MKNK20.86813648
65MAP2K30.86544051
66TESK10.86430045
67PBK0.85740872
68CSNK1A1L0.85426918
69CSNK1G10.85410097
70CHEK10.85393830
71PAK10.81337711
72MAP3K30.78944439
73* MAP3K80.78031779
74MAP4K20.77780505
75BRAF0.77357479
76OBSCN0.71850272
77ABL20.70943309
78PRKCI0.70739181
79MET0.70302712
80SCYL20.69502070
81* CSNK2A10.68484506
82CSNK1G20.67042111
83BRD40.66881413
84BRSK10.66273089
85* CSNK2A20.64176162
86ERBB40.64144512
87PKN20.63219353
88PDK20.63091484
89CDK20.60949101
90AKT20.60186558
91LMTK20.53259278
92PDK40.51850700
93PDK30.51850700
94* ATM0.51718861
95ILK0.51054772
96CDK60.50228668
97LRRK20.49915017
98BMX0.47285596
99TTN0.47243575
100PNCK0.46714156
101CDK80.46227451
102IKBKB0.45342306
103STK30.44533752
104ALK0.42560305
105EEF2K0.41393997
106DAPK30.41353044
107MAPKAPK50.40084529
108PAK20.39176990
109MELK0.37076350
110PTK20.36340318
111BLK0.35234894
112MST1R0.34478176
113* MTOR0.34367770
114MYLK0.34093783
115* CDK10.33897281
116LATS10.31554954
117LIMK10.31384317
118CCNB10.31229399
119TIE10.31191236
120ERN10.30800172
121CDK11A0.28900348
122STK240.27023239
123MAP3K100.25441504
124DDR20.25382462
125* RPS6KA50.24234258
126CDK140.24164168
127PRKD30.24163739
128CDK90.23564724
129WNK40.21245465
130IRAK20.20474264

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30299186
2Ribosome_Homo sapiens_hsa030104.03740483
3Mismatch repair_Homo sapiens_hsa034303.82806894
4Proteasome_Homo sapiens_hsa030503.72389106
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57557480
6RNA polymerase_Homo sapiens_hsa030203.47404982
7One carbon pool by folate_Homo sapiens_hsa006703.01478321
8Spliceosome_Homo sapiens_hsa030402.89466302
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80703941
10* RNA transport_Homo sapiens_hsa030132.72088437
11Base excision repair_Homo sapiens_hsa034102.67097403
12Homologous recombination_Homo sapiens_hsa034402.67063646
13Nucleotide excision repair_Homo sapiens_hsa034202.55380754
14Pyrimidine metabolism_Homo sapiens_hsa002402.53266897
15Cell cycle_Homo sapiens_hsa041102.01559341
16Fanconi anemia pathway_Homo sapiens_hsa034601.93748094
17p53 signaling pathway_Homo sapiens_hsa041151.62467381
18Basal transcription factors_Homo sapiens_hsa030221.61378068
19RNA degradation_Homo sapiens_hsa030181.55258289
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52669973
21Non-homologous end-joining_Homo sapiens_hsa034501.51524133
22Fatty acid elongation_Homo sapiens_hsa000621.47751832
23Folate biosynthesis_Homo sapiens_hsa007901.37684169
24Purine metabolism_Homo sapiens_hsa002301.29943840
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25980171
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21641726
27Biosynthesis of amino acids_Homo sapiens_hsa012301.20898880
28mRNA surveillance pathway_Homo sapiens_hsa030151.12344780
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.08886781
30Epstein-Barr virus infection_Homo sapiens_hsa051691.04959812
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01689832
32Pentose phosphate pathway_Homo sapiens_hsa000300.98556445
33Carbon metabolism_Homo sapiens_hsa012000.98043561
34Huntingtons disease_Homo sapiens_hsa050160.97312462
35Selenocompound metabolism_Homo sapiens_hsa004500.96521637
36N-Glycan biosynthesis_Homo sapiens_hsa005100.95058955
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92352874
38Sulfur metabolism_Homo sapiens_hsa009200.91110010
39Glutathione metabolism_Homo sapiens_hsa004800.90785880
40Fructose and mannose metabolism_Homo sapiens_hsa000510.87044723
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86916740
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.86915068
43Parkinsons disease_Homo sapiens_hsa050120.86912672
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83781252
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.83229677
46Oxidative phosphorylation_Homo sapiens_hsa001900.81095922
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81077523
48Systemic lupus erythematosus_Homo sapiens_hsa053220.77328478
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73771901
50Sulfur relay system_Homo sapiens_hsa041220.73215523
51Galactose metabolism_Homo sapiens_hsa000520.70480715
52Protein export_Homo sapiens_hsa030600.67826964
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64774495
54Herpes simplex infection_Homo sapiens_hsa051680.63069035
55Arachidonic acid metabolism_Homo sapiens_hsa005900.62527323
56Viral carcinogenesis_Homo sapiens_hsa052030.62253880
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58471395
58Steroid biosynthesis_Homo sapiens_hsa001000.58255928
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56447167
60Legionellosis_Homo sapiens_hsa051340.55401144
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54531277
62Vitamin B6 metabolism_Homo sapiens_hsa007500.53954536
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53845022
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52577164
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52171923
66Vibrio cholerae infection_Homo sapiens_hsa051100.51267149
67HTLV-I infection_Homo sapiens_hsa051660.50768055
68Arginine and proline metabolism_Homo sapiens_hsa003300.46768958
69Metabolic pathways_Homo sapiens_hsa011000.45386108
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43950368
71Small cell lung cancer_Homo sapiens_hsa052220.43607670
72TGF-beta signaling pathway_Homo sapiens_hsa043500.43157436
73Tyrosine metabolism_Homo sapiens_hsa003500.41616857
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41565502
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41206070
76Peroxisome_Homo sapiens_hsa041460.41150326
77Linoleic acid metabolism_Homo sapiens_hsa005910.40250204
78Hippo signaling pathway_Homo sapiens_hsa043900.40163536
79Bladder cancer_Homo sapiens_hsa052190.37708783
80Basal cell carcinoma_Homo sapiens_hsa052170.37159014
81Antigen processing and presentation_Homo sapiens_hsa046120.37059940
82Apoptosis_Homo sapiens_hsa042100.36724837
83Fatty acid metabolism_Homo sapiens_hsa012120.36018047
84MicroRNAs in cancer_Homo sapiens_hsa052060.35418813
85Thyroid cancer_Homo sapiens_hsa052160.34609267
86Oocyte meiosis_Homo sapiens_hsa041140.32445065
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32153097
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31242448
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30583355
90* HIF-1 signaling pathway_Homo sapiens_hsa040660.30059920
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29066915
92Alzheimers disease_Homo sapiens_hsa050100.28264724
93Fat digestion and absorption_Homo sapiens_hsa049750.28039606
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27132109
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26983166
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26513366
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24361534
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.23829837
99Collecting duct acid secretion_Homo sapiens_hsa049660.23739749
100Arginine biosynthesis_Homo sapiens_hsa002200.23072562
101Pyruvate metabolism_Homo sapiens_hsa006200.21611758
102Other glycan degradation_Homo sapiens_hsa005110.21202672
103Propanoate metabolism_Homo sapiens_hsa006400.20517655
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19893429
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19234231
106Melanoma_Homo sapiens_hsa052180.17994671
107Adherens junction_Homo sapiens_hsa045200.17182057
108Vitamin digestion and absorption_Homo sapiens_hsa049770.16734242
109Phenylalanine metabolism_Homo sapiens_hsa003600.16278937
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15833777
111Pathways in cancer_Homo sapiens_hsa052000.15762187
112Renin-angiotensin system_Homo sapiens_hsa046140.15427203
113Shigellosis_Homo sapiens_hsa051310.14880480
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14415049
115Notch signaling pathway_Homo sapiens_hsa043300.14169183
116beta-Alanine metabolism_Homo sapiens_hsa004100.14102271
117Fatty acid degradation_Homo sapiens_hsa000710.13604790
118Cardiac muscle contraction_Homo sapiens_hsa042600.13512621
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.13193167
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13191640
121ECM-receptor interaction_Homo sapiens_hsa045120.12823245
122Regulation of autophagy_Homo sapiens_hsa041400.12820320
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11724244
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08301420
125Alcoholism_Homo sapiens_hsa050340.07996236
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.03462445

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