EIF4EBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.39597660
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.39597660
3alpha-linolenic acid metabolic process (GO:0036109)4.33788830
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.33612847
5L-phenylalanine metabolic process (GO:0006558)4.33612847
6kynurenine metabolic process (GO:0070189)4.20527113
7glycine metabolic process (GO:0006544)4.15860199
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12248694
9sulfur amino acid catabolic process (GO:0000098)4.09841669
10aromatic amino acid family catabolic process (GO:0009074)4.09113785
11serine family amino acid catabolic process (GO:0009071)4.07272610
12negative regulation of cholesterol transport (GO:0032375)4.06202439
13negative regulation of sterol transport (GO:0032372)4.06202439
14mitotic sister chromatid cohesion (GO:0007064)4.02712594
15urea metabolic process (GO:0019627)3.87780817
16urea cycle (GO:0000050)3.87780817
17cysteine metabolic process (GO:0006534)3.87548294
18negative regulation of fibrinolysis (GO:0051918)3.86022077
19tryptophan catabolic process (GO:0006569)3.84633165
20indole-containing compound catabolic process (GO:0042436)3.84633165
21indolalkylamine catabolic process (GO:0046218)3.84633165
22NADH metabolic process (GO:0006734)3.83084406
23lysine metabolic process (GO:0006553)3.82770200
24lysine catabolic process (GO:0006554)3.82770200
25glyoxylate metabolic process (GO:0046487)3.81529719
26peptidyl-glutamic acid carboxylation (GO:0017187)3.73637384
27protein carboxylation (GO:0018214)3.73637384
28positive regulation of SMAD protein import into nucleus (GO:0060391)3.70750207
29regulation of cholesterol homeostasis (GO:2000188)3.69100232
30tryptophan metabolic process (GO:0006568)3.64175395
31regulation of RNA export from nucleus (GO:0046831)3.59408391
32triglyceride catabolic process (GO:0019433)3.58177885
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53185182
34fatty acid homeostasis (GO:0055089)3.52134965
35complement activation, alternative pathway (GO:0006957)3.46167714
36high-density lipoprotein particle remodeling (GO:0034375)3.45545891
37nitrogen cycle metabolic process (GO:0071941)3.44680924
38serine family amino acid metabolic process (GO:0009069)3.44407531
39regulation of protein activation cascade (GO:2000257)3.42254944
40mRNA stabilization (GO:0048255)3.41056889
41RNA stabilization (GO:0043489)3.41056889
42histone H3-K36 demethylation (GO:0070544)3.40524261
43regulation of fibrinolysis (GO:0051917)3.38004721
44folic acid-containing compound biosynthetic process (GO:0009396)3.37970874
45homocysteine metabolic process (GO:0050667)3.35854738
46bile acid biosynthetic process (GO:0006699)3.35791426
47neutral lipid catabolic process (GO:0046461)3.34927390
48acylglycerol catabolic process (GO:0046464)3.34927390
49embryonic process involved in female pregnancy (GO:0060136)3.31843356
50positive regulation of fatty acid beta-oxidation (GO:0032000)3.30286767
51trophectodermal cell differentiation (GO:0001829)3.30096689
52lipoprotein transport (GO:0042953)3.28756334
53amino-acid betaine metabolic process (GO:0006577)3.27852134
54serine family amino acid biosynthetic process (GO:0009070)3.27357141
55carnitine shuttle (GO:0006853)3.20879832
56regulation of SMAD protein import into nucleus (GO:0060390)3.20828295
57regulation of complement activation (GO:0030449)3.19736764
582-oxoglutarate metabolic process (GO:0006103)3.11809872
59cellular modified amino acid catabolic process (GO:0042219)3.11136886
60regulation of fatty acid beta-oxidation (GO:0031998)3.10382322
61NLS-bearing protein import into nucleus (GO:0006607)3.10179197
62regulation of triglyceride catabolic process (GO:0010896)3.09964824
63acylglycerol homeostasis (GO:0055090)3.06935491
64triglyceride homeostasis (GO:0070328)3.06935491
65imidazole-containing compound metabolic process (GO:0052803)3.05404068
66diacylglycerol metabolic process (GO:0046339)3.05160995
67bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05031891
68bile acid metabolic process (GO:0008206)3.04898339
69regulation of NFAT protein import into nucleus (GO:0051532)3.04818738
70regulation of nucleobase-containing compound transport (GO:0032239)3.03958558
71low-density lipoprotein particle clearance (GO:0034383)3.03151592
72pre-miRNA processing (GO:0031054)3.01440949
73alpha-amino acid catabolic process (GO:1901606)3.01251785
74regulation of chromatin silencing (GO:0031935)3.01242459
75positive regulation of catenin import into nucleus (GO:0035413)3.00469248
76tricarboxylic acid metabolic process (GO:0072350)2.99369511
77valine metabolic process (GO:0006573)2.98744373
78plasma lipoprotein particle assembly (GO:0034377)2.98225501
79ethanol oxidation (GO:0006069)2.98109335
80embryonic retina morphogenesis in camera-type eye (GO:0060059)2.97375767
81embryonic camera-type eye morphogenesis (GO:0048596)2.95636618
82hippo signaling (GO:0035329)2.94646333
83cellular protein complex localization (GO:0034629)2.94585575
84plasma lipoprotein particle clearance (GO:0034381)2.93353186
85dicarboxylic acid biosynthetic process (GO:0043650)2.92279573
86histone H4-K12 acetylation (GO:0043983)2.91413375
87tetrahydrofolate metabolic process (GO:0046653)2.89683561
88bile acid and bile salt transport (GO:0015721)2.86367726
89reverse cholesterol transport (GO:0043691)2.84554014
90regulation of stem cell maintenance (GO:2000036)2.83732234
91negative regulation of lipase activity (GO:0060192)2.83688943
92one-carbon metabolic process (GO:0006730)2.83344834
93cellular amino acid catabolic process (GO:0009063)2.82529346
94aromatic amino acid family metabolic process (GO:0009072)2.81852290
95protein-lipid complex remodeling (GO:0034368)2.81490764
96macromolecular complex remodeling (GO:0034367)2.81490764
97plasma lipoprotein particle remodeling (GO:0034369)2.81490764
98regulation of posttranscriptional gene silencing (GO:0060147)2.81436814
99regulation of gene silencing by miRNA (GO:0060964)2.81436814
100regulation of gene silencing by RNA (GO:0060966)2.81436814
101nucleosome disassembly (GO:0006337)2.80866282
102protein-DNA complex disassembly (GO:0032986)2.80866282
103negative regulation of fatty acid biosynthetic process (GO:0045717)2.79803080
104regulation of translational fidelity (GO:0006450)2.78006983
105protein complex localization (GO:0031503)2.77837104
106regulation of bile acid biosynthetic process (GO:0070857)2.76211352
107cellular ketone body metabolic process (GO:0046950)2.75208619
108negative regulation of DNA repair (GO:0045738)2.74085881
109protein-lipid complex assembly (GO:0065005)2.73357210
110positive regulation of gene expression, epigenetic (GO:0045815)2.72541904
111biotin metabolic process (GO:0006768)2.71284618
112polyol transport (GO:0015791)2.70662105
113phospholipid efflux (GO:0033700)2.70480190
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69925726
115triglyceride biosynthetic process (GO:0019432)2.66986401
116acetyl-CoA metabolic process (GO:0006084)2.66689275
117L-serine metabolic process (GO:0006563)2.66407071
118protein localization to microtubule (GO:0035372)2.64081151
119regulation of cholesterol esterification (GO:0010872)2.63628023
120notochord development (GO:0030903)2.63000911
121positive regulation of lipid catabolic process (GO:0050996)2.62942761
122glucocorticoid receptor signaling pathway (GO:0042921)2.62005875
123nuclear pore complex assembly (GO:0051292)2.60309070
124cellular response to epidermal growth factor stimulus (GO:0071364)2.59933353
125intestinal cholesterol absorption (GO:0030299)2.59309032
126negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59209210
127negative regulation of translation, ncRNA-mediated (GO:0040033)2.59209210
128regulation of translation, ncRNA-mediated (GO:0045974)2.59209210
129positive regulation of triglyceride metabolic process (GO:0090208)2.59133342
130tyrosine metabolic process (GO:0006570)2.58834529
131glutamate metabolic process (GO:0006536)2.58171869
132gastrulation with mouth forming second (GO:0001702)2.57263244
133benzene-containing compound metabolic process (GO:0042537)2.56818549
134regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.56656482
135nuclear pore organization (GO:0006999)2.56333030
136transcytosis (GO:0045056)2.55206816
137DNA unwinding involved in DNA replication (GO:0006268)2.55083047
138cholesterol homeostasis (GO:0042632)2.53990019
139regulation of cell fate specification (GO:0042659)2.53659845
140thioester biosynthetic process (GO:0035384)2.52296111
141acyl-CoA biosynthetic process (GO:0071616)2.52296111
142mitotic chromosome condensation (GO:0007076)2.51759853
143neutral lipid biosynthetic process (GO:0046460)2.51412279
144acylglycerol biosynthetic process (GO:0046463)2.51412279
145sterol homeostasis (GO:0055092)2.50988597
146paraxial mesoderm development (GO:0048339)2.50879826
1474-hydroxyproline metabolic process (GO:0019471)2.50796307
148phospholipid homeostasis (GO:0055091)2.50717872
149convergent extension (GO:0060026)2.50347872
150intestinal absorption (GO:0050892)2.50343814
151adherens junction assembly (GO:0034333)2.50282151
152response to epidermal growth factor (GO:0070849)2.50232182
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50075564
154cellular hyperosmotic response (GO:0071474)2.48840575
155fatty acid transmembrane transport (GO:1902001)2.48605074
156epoxygenase P450 pathway (GO:0019373)2.48429162
157indolalkylamine metabolic process (GO:0006586)2.46763723
158positive regulation of triglyceride biosynthetic process (GO:0010867)2.46485286
159fatty-acyl-CoA metabolic process (GO:0035337)2.46308678
160very-low-density lipoprotein particle assembly (GO:0034379)2.46148934
161aspartate family amino acid catabolic process (GO:0009068)2.46112391
162heterochromatin organization (GO:0070828)2.45355391
163CDP-diacylglycerol biosynthetic process (GO:0016024)2.44866238
164triglyceride metabolic process (GO:0006641)2.44730546
165cholesterol efflux (GO:0033344)2.44676828
1663-UTR-mediated mRNA stabilization (GO:0070935)2.44092720
167carnitine transport (GO:0015879)2.43336695
168amino-acid betaine transport (GO:0015838)2.43336695
169negative regulation of lipid transport (GO:0032369)2.43085145
170positive regulation of histone deacetylation (GO:0031065)2.42511091
171positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.42190614
172oxaloacetate metabolic process (GO:0006107)2.41475948
173cytolysis (GO:0019835)2.41343511
174maternal placenta development (GO:0001893)2.40869594
175establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.40040532
176DNA topological change (GO:0006265)2.38678013
177regulation of sequestering of triglyceride (GO:0010889)2.38245065
178negative regulation of fibroblast apoptotic process (GO:2000270)2.37919209
179negative regulation of gene silencing (GO:0060969)2.37847747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47116185
2E2F7_22180533_ChIP-Seq_HELA_Human4.91279457
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.88706454
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.78831809
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30327350
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.20080119
7MYC_22102868_ChIP-Seq_BL_Human3.05555853
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.91558638
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.55105906
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.46142112
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42705724
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42354408
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.41473750
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31387558
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29922479
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.19922965
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17485066
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16367268
19* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03835910
20VDR_21846776_ChIP-Seq_THP-1_Human2.03079027
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00448435
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95602727
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86173346
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85889318
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83275549
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82247486
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81861817
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81797681
29CLOCK_20551151_ChIP-Seq_293T_Human1.80947175
30GATA1_22025678_ChIP-Seq_K562_Human1.80484372
31DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.79267181
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.79250094
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75711937
34TCF7_22412390_ChIP-Seq_EML_Mouse1.72637578
35* MYC_18555785_ChIP-Seq_MESCs_Mouse1.69219130
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68611060
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60030994
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56658152
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52720875
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51363762
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.51169035
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50449404
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49192320
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42990107
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.40340157
46ZNF263_19887448_ChIP-Seq_K562_Human1.40007442
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38248827
48MAF_26560356_Chip-Seq_TH1_Human1.37740826
49* KDM2B_26808549_Chip-Seq_DND41_Human1.36817445
50* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36240003
51AR_21909140_ChIP-Seq_LNCAP_Human1.33960835
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.33082541
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32547156
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32035422
55UTX_26944678_Chip-Seq_JUKART_Human1.30208711
56SCL_19346495_ChIP-Seq_HPC-7_Human1.27206392
57LXR_22292898_ChIP-Seq_THP-1_Human1.26986693
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.26865611
59* TBX20_22328084_ChIP-Seq_HEART_Mouse1.24982395
60* TBX20_22080862_ChIP-Seq_HEART_Mouse1.24982395
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24929581
62CIITA_25753668_ChIP-Seq_RAJI_Human1.24573278
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24487518
64* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24053891
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23566766
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23533636
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23271122
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21488829
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21186851
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.21169145
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20863781
72* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19934644
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.18136283
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17155623
75PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16753328
76* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16302302
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.16232143
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15470380
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15254200
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14838223
81* KDM2B_26808549_Chip-Seq_K562_Human1.14500985
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14232710
83* RACK7_27058665_Chip-Seq_MCF-7_Human1.13868749
84XRN2_22483619_ChIP-Seq_HELA_Human1.13608359
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13452949
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10850380
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10651433
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10384805
89KDM5A_27292631_Chip-Seq_BREAST_Human1.08991430
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.08840200
91* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07212285
92* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07061631
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06552763
94NCOR1_26117541_ChIP-Seq_K562_Human1.05320874
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05309791
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05198151
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05011057
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04450364
99ATF3_27146783_Chip-Seq_COLON_Human1.04061529
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04050784
101* GATA6_25053715_ChIP-Seq_YYC3_Human1.03731966
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03443317
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02379867
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02363081
105MAF_26560356_Chip-Seq_TH2_Human1.01062560
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.00746920
107MYB_26560356_Chip-Seq_TH1_Human0.99928446
108CHD1_26751641_Chip-Seq_LNCaP_Human0.99403482
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98969907
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98936576
111* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98415546
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.98261289
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97839374
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97610925
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97512040
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97308180
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95912474
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95661033
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95553361
120VDR_24763502_ChIP-Seq_THP-1_Human0.95139367
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95053867
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94706131
123* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94358285
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93936394
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.93827635
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93112717
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92608375
128NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91965114
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91713041
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91611132
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90626642
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90013379
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89877019
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.89517201
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89483058
136NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88810929
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88710951
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88109791
139BP1_19119308_ChIP-ChIP_Hs578T_Human0.87335970
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86354056
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85341323
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85341323
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85341323
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85095012
145MYB_26560356_Chip-Seq_TH2_Human0.83528927
146HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83273561
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82932253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.03472980
2MP0005360_urolithiasis4.94279967
3MP0005365_abnormal_bile_salt4.20391546
4MP0005085_abnormal_gallbladder_physiolo3.80606540
5MP0002009_preneoplasia2.88008305
6MP0003806_abnormal_nucleotide_metabolis2.80087829
7MP0003705_abnormal_hypodermis_morpholog2.78632008
8MP0008875_abnormal_xenobiotic_pharmacok2.69735744
9MP0003252_abnormal_bile_duct2.62577989
10MP0009840_abnormal_foam_cell2.52810969
11MP0005409_darkened_coat_color2.52014889
12MP0010329_abnormal_lipoprotein_level2.28155375
13MP0008057_abnormal_DNA_replication2.22006659
14MP0002796_impaired_skin_barrier1.98354879
15MP0005076_abnormal_cell_differentiation1.96111479
16MP0010352_gastrointestinal_tract_polyps1.91735702
17MP0010234_abnormal_vibrissa_follicle1.91610401
18MP0003941_abnormal_skin_development1.86210158
19MP0000609_abnormal_liver_physiology1.81592756
20MP0006138_congestive_heart_failure1.78528151
21MP0005083_abnormal_biliary_tract1.77185351
22MP0001666_abnormal_nutrient_absorption1.72780220
23MP0009053_abnormal_anal_canal1.68947855
24MP0004264_abnormal_extraembryonic_tissu1.54622297
25MP0000537_abnormal_urethra_morphology1.50501157
26MP0005332_abnormal_amino_acid1.46042773
27MP0000428_abnormal_craniofacial_morphol1.42484159
28MP0003300_gastrointestinal_ulcer1.41578716
29MP0003191_abnormal_cellular_cholesterol1.32692759
30MP0010030_abnormal_orbit_morphology1.32511695
31MP0005319_abnormal_enzyme/_coenzyme1.32003777
32MP0001730_embryonic_growth_arrest1.28326489
33MP0002396_abnormal_hematopoietic_system1.27260476
34MP0000598_abnormal_liver_morphology1.25859940
35MP0003984_embryonic_growth_retardation1.25564343
36MP0003077_abnormal_cell_cycle1.25494169
37MP0002088_abnormal_embryonic_growth/wei1.25248585
38MP0002254_reproductive_system_inflammat1.25158252
39MP0004087_abnormal_muscle_fiber1.24737044
40MP0002086_abnormal_extraembryonic_tissu1.23676055
41MP0005380_embryogenesis_phenotype1.22738945
42MP0001672_abnormal_embryogenesis/_devel1.22738945
43MP0004957_abnormal_blastocyst_morpholog1.21404473
44MP0008961_abnormal_basal_metabolism1.19501655
45MP0003111_abnormal_nucleus_morphology1.18337608
46MP0004197_abnormal_fetal_growth/weight/1.18070228
47MP0002118_abnormal_lipid_homeostasis1.18001388
48MP0003828_pulmonary_edema1.17912863
49MP0004858_abnormal_nervous_system1.16749396
50MP0010094_abnormal_chromosome_stability1.16295116
51MP0005248_abnormal_Harderian_gland1.15302409
52MP0003567_abnormal_fetal_cardiomyocyte1.14872384
53MP0003566_abnormal_cell_adhesion1.12522421
54MP0009278_abnormal_bone_marrow1.10327737
55MP0000462_abnormal_digestive_system1.10241779
56MP0001661_extended_life_span1.08918775
57MP0005670_abnormal_white_adipose1.07433220
58MP0004233_abnormal_muscle_weight1.07233103
59MP0000566_synostosis1.07154777
60MP0009672_abnormal_birth_weight1.07033365
61MP0005666_abnormal_adipose_tissue1.07021501
62MP0003878_abnormal_ear_physiology1.06698604
63MP0005377_hearing/vestibular/ear_phenot1.06698604
64MP0003890_abnormal_embryonic-extraembry1.06674986
65MP0003693_abnormal_embryo_hatching1.06261226
66MP0001286_abnormal_eye_development1.06253628
67MP0001849_ear_inflammation1.06000721
68MP0004185_abnormal_adipocyte_glucose1.04291354
69MP0005023_abnormal_wound_healing1.03220684
70MP0005451_abnormal_body_composition1.02697062
71MP0004272_abnormal_basement_membrane1.02260512
72MP0003656_abnormal_erythrocyte_physiolo1.02103584
73MP0002138_abnormal_hepatobiliary_system1.02069572
74MP0001293_anophthalmia1.02055384
75MP0000350_abnormal_cell_proliferation1.01880670
76MP0001697_abnormal_embryo_size0.99001976
77MP0004019_abnormal_vitamin_homeostasis0.97766826
78MP0001544_abnormal_cardiovascular_syste0.96083870
79MP0005385_cardiovascular_system_phenoty0.96083870
80MP0002084_abnormal_developmental_patter0.95294636
81MP0002127_abnormal_cardiovascular_syste0.94690704
82MP0003303_peritoneal_inflammation0.90998336
83MP0003436_decreased_susceptibility_to0.90767154
84MP0003937_abnormal_limbs/digits/tail_de0.90312979
85MP0005501_abnormal_skin_physiology0.89473894
86MP0005397_hematopoietic_system_phenotyp0.89072918
87MP0001545_abnormal_hematopoietic_system0.89072918
88MP0000432_abnormal_head_morphology0.89025829
89MP0004782_abnormal_surfactant_physiolog0.88699723
90MP0003868_abnormal_feces_composition0.87760874
91MP0009697_abnormal_copulation0.87752142
92MP0005334_abnormal_fat_pad0.87326914
93MP0002085_abnormal_embryonic_tissue0.86237764
94MP0009643_abnormal_urine_homeostasis0.85213175
95MP0002080_prenatal_lethality0.84440660
96MP0003221_abnormal_cardiomyocyte_apopto0.83412862
97MP0002089_abnormal_postnatal_growth/wei0.83236465
98MP0000477_abnormal_intestine_morphology0.81993292
99MP0003935_abnormal_craniofacial_develop0.81777992
100MP0010630_abnormal_cardiac_muscle0.81651064
101MP0004130_abnormal_muscle_cell0.80929053
102MP0004808_abnormal_hematopoietic_stem0.80914451
103MP0010368_abnormal_lymphatic_system0.80742475
104MP0002166_altered_tumor_susceptibility0.79438806
105MP0004084_abnormal_cardiac_muscle0.78999763
106MP0008932_abnormal_embryonic_tissue0.78387855
107MP0000377_abnormal_hair_follicle0.77753384
108MP0002970_abnormal_white_adipose0.77496563
109MP0001915_intracranial_hemorrhage0.77421626
110MP0000751_myopathy0.77292912
111MP0010307_abnormal_tumor_latency0.76993177
112MP0003119_abnormal_digestive_system0.76196642
113MP0005584_abnormal_enzyme/coenzyme_acti0.76176721
114MP0002019_abnormal_tumor_incidence0.75773415
115MP0005330_cardiomyopathy0.75282404
116MP0000685_abnormal_immune_system0.74875434
117MP0005220_abnormal_exocrine_pancreas0.73327697
118MP0005266_abnormal_metabolism0.72599136
119MP0002722_abnormal_immune_system0.72178100
120MP0000703_abnormal_thymus_morphology0.72007995
121MP0003186_abnormal_redox_activity0.71529927
122MP0009763_increased_sensitivity_to0.69873290
123MP0000689_abnormal_spleen_morphology0.69663542
124MP0000490_abnormal_crypts_of0.68604779
125MP0005464_abnormal_platelet_physiology0.66773756
126MP0000733_abnormal_muscle_development0.66397269
127MP0003763_abnormal_thymus_physiology0.65833239
128MP0003115_abnormal_respiratory_system0.65697733
129MP0002092_abnormal_eye_morphology0.65523480
130MP0009703_decreased_birth_body0.65356589
131MP0002398_abnormal_bone_marrow0.65343501
132MP0005375_adipose_tissue_phenotype0.62131350
133MP0002925_abnormal_cardiovascular_devel0.61784342
134MP0002269_muscular_atrophy0.61599951
135MP0009115_abnormal_fat_cell0.61519287
136MP0002971_abnormal_brown_adipose0.61210696
137MP0000266_abnormal_heart_morphology0.59028292
138MP0005647_abnormal_sex_gland0.58085782
139MP0002697_abnormal_eye_size0.57584751
140MP0004947_skin_inflammation0.57437043

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.27619069
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.64265426
3Intrahepatic cholestasis (HP:0001406)4.61970557
4Hypobetalipoproteinemia (HP:0003563)4.14286784
5Xanthomatosis (HP:0000991)4.02316930
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91597689
7Hepatoblastoma (HP:0002884)3.48915009
8Abnormality of sulfur amino acid metabolism (HP:0004339)3.43953903
9Complement deficiency (HP:0004431)3.37524840
10Prolonged partial thromboplastin time (HP:0003645)3.36399671
11Hyperammonemia (HP:0001987)3.26793706
12Hypolipoproteinemia (HP:0010981)3.03323567
13Abnormality of pyrimidine metabolism (HP:0004353)3.03101217
14Hyperlipoproteinemia (HP:0010980)3.03055778
15Ketosis (HP:0001946)2.99066242
16Hyperglycinemia (HP:0002154)2.98862135
17Abnormality of the common coagulation pathway (HP:0010990)2.93901726
18Neonatal hypoglycemia (HP:0001998)2.93275731
19High anterior hairline (HP:0009890)2.87785064
20Hypochromic microcytic anemia (HP:0004840)2.86282174
21Cortical dysplasia (HP:0002539)2.86071193
22Pseudobulbar signs (HP:0002200)2.82272981
23Metaphyseal cupping (HP:0003021)2.81025067
24Joint hemorrhage (HP:0005261)2.79360059
25Epidermoid cyst (HP:0200040)2.77236824
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76919372
27Abnormality of glycine metabolism (HP:0010895)2.76394863
28Abnormality of serine family amino acid metabolism (HP:0010894)2.76394863
29Hyperglycinuria (HP:0003108)2.75067973
30Abnormality of the left ventricular outflow tract (HP:0011103)2.71758753
31Subaortic stenosis (HP:0001682)2.71758753
32Spastic diplegia (HP:0001264)2.68352970
33Delayed CNS myelination (HP:0002188)2.67476542
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.66281794
35Papillary thyroid carcinoma (HP:0002895)2.63181072
36Hypoalphalipoproteinemia (HP:0003233)2.61742328
37Difficulty running (HP:0009046)2.61063672
38Hypercholesterolemia (HP:0003124)2.60488130
39Abnormality of complement system (HP:0005339)2.60246034
40Malignant gastrointestinal tract tumors (HP:0006749)2.59766135
41Gastrointestinal carcinoma (HP:0002672)2.59766135
42Asymmetry of the thorax (HP:0001555)2.58536985
43Hypoglycemic coma (HP:0001325)2.56429185
44Nephroblastoma (Wilms tumor) (HP:0002667)2.50746263
45Myocardial infarction (HP:0001658)2.45725715
46Esophageal varix (HP:0002040)2.42654018
47Disproportionate tall stature (HP:0001519)2.41098045
48Fat malabsorption (HP:0002630)2.35808362
49Abnormality of nucleobase metabolism (HP:0010932)2.34470063
50Embryonal renal neoplasm (HP:0011794)2.31791844
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30821692
52Abnormality of the intrinsic pathway (HP:0010989)2.30561620
53Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.29128136
54Abnormality of methionine metabolism (HP:0010901)2.27894763
55Long eyelashes (HP:0000527)2.27269589
56Hepatocellular carcinoma (HP:0001402)2.26794753
57Ependymoma (HP:0002888)2.22264268
58Macroorchidism (HP:0000053)2.21124264
59Skull defect (HP:0001362)2.19241193
60Hyperbilirubinemia (HP:0002904)2.17719691
61Flat acetabular roof (HP:0003180)2.14055001
62Abnormal platelet volume (HP:0011876)2.11832704
63Increased mean platelet volume (HP:0011877)2.11288379
64Curly hair (HP:0002212)2.09483244
65Uterine leiomyosarcoma (HP:0002891)2.09092054
66Leiomyosarcoma (HP:0100243)2.09092054
67Hemangiomatosis (HP:0007461)2.08911563
68Reticulocytosis (HP:0001923)2.06450724
69Hypochromic anemia (HP:0001931)2.06304910
70Osteomalacia (HP:0002749)2.05150581
71Hyperacusis (HP:0010780)2.04381187
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.01599637
73Abnormality of purine metabolism (HP:0004352)2.00154486
74Transitional cell carcinoma of the bladder (HP:0006740)1.99694927
75Abnormality of fatty-acid metabolism (HP:0004359)1.99075258
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97949580
77Germ cell neoplasia (HP:0100728)1.97675384
78Visceral angiomatosis (HP:0100761)1.97473489
79Back pain (HP:0003418)1.96295004
80Choanal stenosis (HP:0000452)1.95985990
81Cystic hygroma (HP:0000476)1.95067690
82Abnormality of the fingertips (HP:0001211)1.94783809
83Anal stenosis (HP:0002025)1.93037825
84Abnormal vertebral ossification (HP:0100569)1.92997602
85Lymphangioma (HP:0100764)1.91189538
86Skin nodule (HP:0200036)1.88177492
87Abnormality of the Achilles tendon (HP:0005109)1.86814126
88Arnold-Chiari malformation (HP:0002308)1.86292727
89Poikilocytosis (HP:0004447)1.85861091
90Diastasis recti (HP:0001540)1.85519079
91Ventricular tachycardia (HP:0004756)1.84837697
92Acute myeloid leukemia (HP:0004808)1.83748892
93Embryonal neoplasm (HP:0002898)1.83584263
94Polycythemia (HP:0001901)1.83402769
95Renovascular hypertension (HP:0100817)1.82980265
96Deep philtrum (HP:0002002)1.82732927
97Renal duplication (HP:0000075)1.82062703
98Urethral obstruction (HP:0000796)1.81419126
99Biliary tract neoplasm (HP:0100574)1.81410870
100Late onset (HP:0003584)1.78640956
101Abnormality of endocrine pancreas physiology (HP:0012093)1.78622282
102Abnormality of the pancreatic islet cells (HP:0006476)1.78622282
103Abnormality of serum amino acid levels (HP:0003112)1.78621100
104Abnormal foot bone ossification (HP:0010675)1.78466188
105Right ventricular cardiomyopathy (HP:0011663)1.78107284
106Abnormal cartilage morphology (HP:0002763)1.77866939
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.77203157
108Gingival bleeding (HP:0000225)1.75836862
109Gout (HP:0001997)1.75610960
110Eczematoid dermatitis (HP:0000976)1.74801432
111Ankyloglossia (HP:0010296)1.73966392
112Abnormality of the salivary glands (HP:0010286)1.73647331
113Abnormality of the parathyroid morphology (HP:0011766)1.73112264
114Uterine neoplasm (HP:0010784)1.72844648
115Ketoacidosis (HP:0001993)1.72750839
116Mitral valve prolapse (HP:0001634)1.72515489
117Abnormal hair whorl (HP:0010721)1.71776778
118Abnormality of skeletal muscle fiber size (HP:0012084)1.71086046
119Bladder carcinoma (HP:0002862)1.71033692
120Bladder neoplasm (HP:0009725)1.71033692
121Abnormal tarsal ossification (HP:0008369)1.70900200
122Wide cranial sutures (HP:0010537)1.70869994
123Abnormality of iron homeostasis (HP:0011031)1.70321458
124Short 4th metacarpal (HP:0010044)1.70024647
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70024647
126Abnormality of the 4th metacarpal (HP:0010012)1.69296976
127Rhabdomyosarcoma (HP:0002859)1.68869889
128Obsessive-compulsive behavior (HP:0000722)1.68670138
129Deviation of the thumb (HP:0009603)1.66841100
130Rectal prolapse (HP:0002035)1.65681598
131Cholelithiasis (HP:0001081)1.65621533
132Proximal placement of thumb (HP:0009623)1.65178496
133Skin tags (HP:0010609)1.64657559
134Abnormality of transition element cation homeostasis (HP:0011030)1.64292794
135Malnutrition (HP:0004395)1.64096464
136Abnormality of the aortic arch (HP:0012303)1.63545707
137Multiple enchondromatosis (HP:0005701)1.62959101
138Metabolic acidosis (HP:0001942)1.62850445
139Neonatal onset (HP:0003623)1.62655218
140Thyroid carcinoma (HP:0002890)1.62596944
141Thrombophlebitis (HP:0004418)1.62327776
142Spinal cord lesions (HP:0100561)1.62284948
143Syringomyelia (HP:0003396)1.62284948
144Cutis marmorata (HP:0000965)1.61957277
145Steatorrhea (HP:0002570)1.61393383
146Increased variability in muscle fiber diameter (HP:0003557)1.61299726
147Abnormality of the calcaneus (HP:0008364)1.60761878
148Chin dimple (HP:0010751)1.60007014
149Hemorrhage of the eye (HP:0011885)1.58004896
150Acanthocytosis (HP:0001927)1.57737711
151Vertebral clefting (HP:0008428)1.57465840
152Abnormality of the lower motor neuron (HP:0002366)1.56602647
153Omphalocele (HP:0001539)1.56572925
154Menorrhagia (HP:0000132)1.56114442
155Hyperactive renin-angiotensin system (HP:0000841)1.56105164
156Hyporeflexia of lower limbs (HP:0002600)1.54771287
157Increased nuchal translucency (HP:0010880)1.54450424
158Mitral stenosis (HP:0001718)1.54004850
159Thin ribs (HP:0000883)1.53579842
160Broad palm (HP:0001169)1.53548410
161Coronal craniosynostosis (HP:0004440)1.53497703
162Long clavicles (HP:0000890)1.53264319
163Overgrowth (HP:0001548)1.52504999
164Renal cell carcinoma (HP:0005584)1.52450243
165Precocious puberty (HP:0000826)1.52165726
166Vertebral arch anomaly (HP:0008438)1.52160161
167Medulloblastoma (HP:0002885)1.52062796
168Ulnar bowing (HP:0003031)1.51270047
169Broad thumb (HP:0011304)1.51037995
170Increased serum ferritin (HP:0003281)1.50890449
171Sudden death (HP:0001699)1.50811617
172Neoplasm of the small intestine (HP:0100833)1.49908519
173Elfin facies (HP:0004428)1.49701033
174Preauricular skin tag (HP:0000384)1.49575990
175Prenatal maternal abnormality (HP:0002686)1.49476967
176Abnormal gallbladder morphology (HP:0012437)1.49137082
177Spontaneous hematomas (HP:0007420)1.48912674
178Absent eyebrow (HP:0002223)1.48611442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.44021582
2ERN14.14212510
3EEF2K3.54893294
4MAP3K103.31131158
5SMG13.29432912
6TRIB32.79095488
7PKN22.54810448
8SIK12.48396912
9ICK2.43552450
10BCKDK2.10254526
11NLK2.04010096
12YES11.95765229
13TAF11.92678300
14TAOK21.91047332
15FGFR41.89503603
16MAP4K11.81290649
17NEK21.67923269
18SIK31.67569909
19MAPKAPK31.62925413
20STK101.62056569
21LATS11.61850571
22MAP2K31.59492911
23LATS21.57451065
24PTK61.52509869
25BRD41.52508866
26GRK61.41972485
27CDK41.40837478
28CAMK1D1.39405139
29SGK21.39233475
30TTN1.37034094
31CDC71.35815565
32CDK61.30100916
33STK241.29652541
34* MTOR1.28351326
35SGK31.28305850
36KSR21.27608058
37PRPF4B1.26831525
38SCYL21.26123275
39RPS6KB21.25853069
40BMX1.23119780
41FLT31.20811459
42PAK41.17994979
43CDK71.16957973
44BRSK21.13979461
45PRKAA21.10924342
46TNIK1.09687539
47RIPK41.09621680
48AKT31.09340226
49WNK11.09242092
50LRRK21.08103480
51DYRK31.07875340
52MAPK110.99958432
53CDK190.98936459
54SGK4940.97954338
55SGK2230.97954338
56MAP3K110.96364943
57RET0.92987071
58STK30.89812826
59OBSCN0.88512051
60CAMK1G0.88191786
61PDGFRA0.87663159
62KSR10.86439311
63DMPK0.85672935
64NEK10.85520911
65TAOK30.85214443
66TYK20.84551634
67PIK3CA0.83929601
68RPS6KA40.83158445
69MAP3K20.80600485
70RIPK10.80338259
71ZAP700.79127740
72CSF1R0.77255982
73MELK0.76935012
74MKNK10.76330303
75PIM10.73398351
76MAP3K80.73273501
77MAP3K70.72360450
78STK40.72237567
79FGFR30.72229514
80TTK0.71840841
81MARK20.71535137
82PASK0.71346344
83BTK0.70803508
84ACVR1B0.67378136
85CHUK0.66226555
86FGFR10.66147058
87HIPK20.63293980
88MKNK20.63163535
89STK390.63118993
90STK38L0.61587800
91KDR0.60940456
92UHMK10.60876246
93CAMK40.60654163
94CHEK10.59964697
95CLK10.59516194
96DYRK1B0.58595956
97MAP3K30.57943398
98AKT20.57603167
99CSK0.57395220
100JAK30.57076078
101OXSR10.56412543
102TAOK10.56404084
103EIF2AK10.55874798
104ATR0.55847535
105ALK0.55412168
106PTK20.54111011
107PIK3CG0.53451439
108TGFBR20.52575292
109EPHA20.51988690
110ITK0.51707124
111JAK20.51395126
112EPHB20.49216186
113CDK20.48856361
114EPHA30.48789986
115PAK20.48299969
116TGFBR10.48023497
117RPS6KA10.47542087
118RPS6KC10.47254790
119RPS6KL10.47254790
120PDGFRB0.47193619
121MAP3K50.45095616
122PLK10.44775186
123EGFR0.43975088
124MAP3K60.43536586
125CASK0.43307481
126WEE10.41924401
127AURKB0.41820849
128RPS6KA60.41553289
129EPHB10.40495056
130MAPKAPK20.40410159
131SIK20.40118292
132STK110.39839218
133FGFR20.38883517
134TYRO30.38214478
135SRPK10.37580422
136TESK20.35902543
137PLK40.35785146
138ERBB20.34937534
139CDK10.34662891
140MAPK100.34472486
141TBK10.34336590
142AKT10.34118989
143MAPK10.32721266
144GSK3A0.32342057
145ATM0.31805849
146PRKAA10.29945021

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32473810
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29151061
3Nitrogen metabolism_Homo sapiens_hsa009103.12296616
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95809757
5Arginine biosynthesis_Homo sapiens_hsa002202.62019948
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38776985
7Tryptophan metabolism_Homo sapiens_hsa003802.27803719
8Fatty acid degradation_Homo sapiens_hsa000712.26864132
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09790775
10Complement and coagulation cascades_Homo sapiens_hsa046102.05051247
11Selenocompound metabolism_Homo sapiens_hsa004502.04367778
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03465878
13Lysine degradation_Homo sapiens_hsa003102.01015011
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95363958
15One carbon pool by folate_Homo sapiens_hsa006701.94326332
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84961015
17Endometrial cancer_Homo sapiens_hsa052131.82985765
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77124329
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.68944540
20Fatty acid metabolism_Homo sapiens_hsa012121.68192425
21Biosynthesis of amino acids_Homo sapiens_hsa012301.62577332
22PPAR signaling pathway_Homo sapiens_hsa033201.61522033
23Caffeine metabolism_Homo sapiens_hsa002321.50654881
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46304595
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45227021
26Propanoate metabolism_Homo sapiens_hsa006401.43741295
27Butanoate metabolism_Homo sapiens_hsa006501.42414717
28Staphylococcus aureus infection_Homo sapiens_hsa051501.41686107
29Prostate cancer_Homo sapiens_hsa052151.39831302
30Colorectal cancer_Homo sapiens_hsa052101.39084044
31Non-small cell lung cancer_Homo sapiens_hsa052231.37071739
32Carbon metabolism_Homo sapiens_hsa012001.34978904
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.30346909
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27984741
35Peroxisome_Homo sapiens_hsa041461.27421531
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.27368028
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26919529
38Chemical carcinogenesis_Homo sapiens_hsa052041.24312885
39Renal cell carcinoma_Homo sapiens_hsa052111.23291326
40beta-Alanine metabolism_Homo sapiens_hsa004101.21576196
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20768260
42Tight junction_Homo sapiens_hsa045301.18897337
43Renin-angiotensin system_Homo sapiens_hsa046141.14264588
44Pancreatic cancer_Homo sapiens_hsa052121.14192393
45Phenylalanine metabolism_Homo sapiens_hsa003601.13674797
46Sulfur relay system_Homo sapiens_hsa041221.12950864
47Bile secretion_Homo sapiens_hsa049761.12112174
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.11253709
49Starch and sucrose metabolism_Homo sapiens_hsa005001.08898826
50Fat digestion and absorption_Homo sapiens_hsa049751.07970146
51Histidine metabolism_Homo sapiens_hsa003401.07376485
52Pyruvate metabolism_Homo sapiens_hsa006201.02236055
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01635195
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.98054341
55ABC transporters_Homo sapiens_hsa020100.96527743
56Pentose phosphate pathway_Homo sapiens_hsa000300.94750668
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94396419
58Retinol metabolism_Homo sapiens_hsa008300.94334550
59Fatty acid elongation_Homo sapiens_hsa000620.93215653
60Choline metabolism in cancer_Homo sapiens_hsa052310.92813953
61Folate biosynthesis_Homo sapiens_hsa007900.87150384
62Wnt signaling pathway_Homo sapiens_hsa043100.83924369
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83801472
64DNA replication_Homo sapiens_hsa030300.83542353
65Insulin resistance_Homo sapiens_hsa049310.82591417
66Tyrosine metabolism_Homo sapiens_hsa003500.80838966
67Glioma_Homo sapiens_hsa052140.77577087
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76749544
69ErbB signaling pathway_Homo sapiens_hsa040120.76098353
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74260495
71Protein digestion and absorption_Homo sapiens_hsa049740.73454297
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72998956
73Non-homologous end-joining_Homo sapiens_hsa034500.70886205
74Arginine and proline metabolism_Homo sapiens_hsa003300.68886755
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68671822
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68580408
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.68050153
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67338518
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.67039948
80Focal adhesion_Homo sapiens_hsa045100.66829014
81Notch signaling pathway_Homo sapiens_hsa043300.65641558
82Inositol phosphate metabolism_Homo sapiens_hsa005620.64733631
83Prolactin signaling pathway_Homo sapiens_hsa049170.64407839
84FoxO signaling pathway_Homo sapiens_hsa040680.63437967
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63228034
86* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62615863
87Acute myeloid leukemia_Homo sapiens_hsa052210.61170977
88Adherens junction_Homo sapiens_hsa045200.60375959
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59707229
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.59510816
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59244247
92Chronic myeloid leukemia_Homo sapiens_hsa052200.58414384
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58113227
94* RNA transport_Homo sapiens_hsa030130.58010427
95Base excision repair_Homo sapiens_hsa034100.57956984
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55488511
97mRNA surveillance pathway_Homo sapiens_hsa030150.54978803
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.54606816
99Cell cycle_Homo sapiens_hsa041100.54254548
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54101943
101AMPK signaling pathway_Homo sapiens_hsa041520.52792797
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51982375
103Primary immunodeficiency_Homo sapiens_hsa053400.50949642
104Melanogenesis_Homo sapiens_hsa049160.48781193
105VEGF signaling pathway_Homo sapiens_hsa043700.48777336
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48536652
107Mismatch repair_Homo sapiens_hsa034300.48194523
108Fatty acid biosynthesis_Homo sapiens_hsa000610.47158859
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46975114
110Basal cell carcinoma_Homo sapiens_hsa052170.46968143
111Spliceosome_Homo sapiens_hsa030400.46786627
112mTOR signaling pathway_Homo sapiens_hsa041500.45712623
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.45397097
114Glycerolipid metabolism_Homo sapiens_hsa005610.44717252
115Vitamin digestion and absorption_Homo sapiens_hsa049770.43575302
116MicroRNAs in cancer_Homo sapiens_hsa052060.41822731
117Vitamin B6 metabolism_Homo sapiens_hsa007500.41390121
118Glutathione metabolism_Homo sapiens_hsa004800.41387604
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39960093
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.39393611
121Small cell lung cancer_Homo sapiens_hsa052220.38613035
122Thyroid cancer_Homo sapiens_hsa052160.37409111
123Galactose metabolism_Homo sapiens_hsa000520.36822302
124Bladder cancer_Homo sapiens_hsa052190.36676979
125Viral myocarditis_Homo sapiens_hsa054160.36433735
126Sulfur metabolism_Homo sapiens_hsa009200.35795756
127Insulin signaling pathway_Homo sapiens_hsa049100.34730175
128Fructose and mannose metabolism_Homo sapiens_hsa000510.34542385
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33026656
130HTLV-I infection_Homo sapiens_hsa051660.31537186
131Glucagon signaling pathway_Homo sapiens_hsa049220.30206956
132Proteoglycans in cancer_Homo sapiens_hsa052050.29931720
133Herpes simplex infection_Homo sapiens_hsa051680.29759298
134Steroid biosynthesis_Homo sapiens_hsa001000.27721712
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27700869
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27462329
137Hippo signaling pathway_Homo sapiens_hsa043900.26877741

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