EIF4EP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)5.59007081
2DNA double-strand break processing (GO:0000729)4.79203384
3protein K11-linked deubiquitination (GO:0035871)4.37719907
4cellular biogenic amine catabolic process (GO:0042402)4.03837533
5amine catabolic process (GO:0009310)4.03837533
6lactate metabolic process (GO:0006089)3.91970990
7regulation of meiosis I (GO:0060631)3.90647672
8synapsis (GO:0007129)3.88061131
9kinetochore organization (GO:0051383)3.85006460
10keratinocyte development (GO:0003334)3.77617577
11regulation of DNA endoreduplication (GO:0032875)3.76741654
12maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.76088148
13protein K6-linked ubiquitination (GO:0085020)3.71933553
14platelet dense granule organization (GO:0060155)3.70977365
15kinetochore assembly (GO:0051382)3.68826411
16regulation of hexokinase activity (GO:1903299)3.68666899
17regulation of glucokinase activity (GO:0033131)3.68666899
18neural tube formation (GO:0001841)3.66647089
19protein heterotetramerization (GO:0051290)3.62439981
20response to pheromone (GO:0019236)3.58874544
21centriole replication (GO:0007099)3.54642733
22double-strand break repair via homologous recombination (GO:0000724)3.35487648
23recombinational repair (GO:0000725)3.31907501
24negative regulation of JUN kinase activity (GO:0043508)3.30860589
25positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.29509855
26regulation of cytokine secretion involved in immune response (GO:0002739)3.28514759
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.26248714
28negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.23974766
29positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.22975359
30negative regulation of transcription regulatory region DNA binding (GO:2000678)3.20287351
31regulation of heat generation (GO:0031650)3.13431057
32DNA ligation (GO:0006266)3.11148115
33attachment of spindle microtubules to kinetochore (GO:0008608)3.10959851
34resolution of meiotic recombination intermediates (GO:0000712)3.08697800
35meiotic chromosome segregation (GO:0045132)3.07730623
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.07512564
37negative regulation of execution phase of apoptosis (GO:1900118)3.07152952
38negative regulation of dendrite development (GO:2000171)3.02450190
39positive regulation of meiosis (GO:0045836)3.00274009
40DNA catabolic process, exonucleolytic (GO:0000738)2.99943625
41limb bud formation (GO:0060174)2.99022826
42negative regulation of mast cell activation (GO:0033004)2.97455076
43auditory receptor cell differentiation (GO:0042491)2.94960476
44fucose catabolic process (GO:0019317)2.94630966
45L-fucose metabolic process (GO:0042354)2.94630966
46L-fucose catabolic process (GO:0042355)2.94630966
47negative regulation of dendrite morphogenesis (GO:0050774)2.93130152
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92489232
49positive regulation of meiotic cell cycle (GO:0051446)2.91612903
50indole-containing compound catabolic process (GO:0042436)2.90535177
51indolalkylamine catabolic process (GO:0046218)2.90535177
52tryptophan catabolic process (GO:0006569)2.90535177
53respiratory chain complex IV assembly (GO:0008535)2.89534370
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88585644
55isotype switching (GO:0045190)2.88585644
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88585644
57regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.87395415
58detection of light stimulus involved in sensory perception (GO:0050962)2.83795222
59detection of light stimulus involved in visual perception (GO:0050908)2.83795222
60Rap protein signal transduction (GO:0032486)2.82307807
61mitotic sister chromatid cohesion (GO:0007064)2.81408254
62histone H2A acetylation (GO:0043968)2.80512301
63single strand break repair (GO:0000012)2.80006773
64reciprocal meiotic recombination (GO:0007131)2.79678850
65reciprocal DNA recombination (GO:0035825)2.79678850
66developmental pigmentation (GO:0048066)2.71990010
67positive regulation of male gonad development (GO:2000020)2.68250762
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67863884
69negative regulation of T-helper cell differentiation (GO:0045623)2.67863884
70histone mRNA catabolic process (GO:0071044)2.67495284
71positive regulation of protein autophosphorylation (GO:0031954)2.65853386
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63811064
73regulation of mesenchymal cell apoptotic process (GO:2001053)2.63086434
74positive regulation of protein homooligomerization (GO:0032464)2.62587987
75DNA demethylation (GO:0080111)2.62175915
76regulation of Rac protein signal transduction (GO:0035020)2.61588043
77tryptophan metabolic process (GO:0006568)2.61025175
78negative regulation of alpha-beta T cell differentiation (GO:0046639)2.60337518
79male meiosis (GO:0007140)2.59465757
80retinal cone cell development (GO:0046549)2.59105955
81protein prenylation (GO:0018342)2.57243134
82prenylation (GO:0097354)2.57243134
83indolalkylamine metabolic process (GO:0006586)2.55196156
84DNA integration (GO:0015074)2.55084422
85sister chromatid segregation (GO:0000819)2.53792275
86cellular biogenic amine biosynthetic process (GO:0042401)2.51858255
87cytochrome complex assembly (GO:0017004)2.50163078
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.49388660
89amine biosynthetic process (GO:0009309)2.48537029
90intestinal epithelial cell development (GO:0060576)2.46496202
91proteasome assembly (GO:0043248)2.44701762
92DNA replication-dependent nucleosome assembly (GO:0006335)2.43131241
93DNA replication-dependent nucleosome organization (GO:0034723)2.43131241
94phospholipid homeostasis (GO:0055091)2.41441596
95mitotic G2/M transition checkpoint (GO:0044818)2.37500894
96anterograde synaptic vesicle transport (GO:0048490)2.37256573
97mitotic sister chromatid segregation (GO:0000070)2.36795298
98intra-S DNA damage checkpoint (GO:0031573)2.36422686
99adenosine metabolic process (GO:0046085)2.36097653
100DNA deamination (GO:0045006)2.35257801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.68894751
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15055204
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83934759
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.76442843
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.72734514
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.68048178
7VDR_22108803_ChIP-Seq_LS180_Human2.52484401
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42128046
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36367188
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.32523515
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13874503
12ZNF274_21170338_ChIP-Seq_K562_Hela2.13746809
13FUS_26573619_Chip-Seq_HEK293_Human2.06240112
14EWS_26573619_Chip-Seq_HEK293_Human2.01560954
15P300_19829295_ChIP-Seq_ESCs_Human2.00867490
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.99790883
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96067813
18TAF15_26573619_Chip-Seq_HEK293_Human1.92701487
19EZH2_27294783_Chip-Seq_NPCs_Mouse1.92328978
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86201666
21ELK1_19687146_ChIP-ChIP_HELA_Human1.85361385
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85145842
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84624832
24ER_23166858_ChIP-Seq_MCF-7_Human1.80958676
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.77966983
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.76084916
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74029989
28GBX2_23144817_ChIP-Seq_PC3_Human1.69636310
29BCAT_22108803_ChIP-Seq_LS180_Human1.68011841
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64900600
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62423007
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.58464168
33IGF1R_20145208_ChIP-Seq_DFB_Human1.57165009
34P53_22387025_ChIP-Seq_ESCs_Mouse1.55935562
35CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52632154
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.52249458
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.51791054
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50796968
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50751619
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48538014
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46930532
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46596522
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.45069544
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44330752
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.43573068
46P300_18555785_Chip-Seq_ESCs_Mouse1.41162736
47SMAD4_21799915_ChIP-Seq_A2780_Human1.40074893
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.39028522
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.38500431
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.37666432
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37455570
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.36378223
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35900669
54CBP_20019798_ChIP-Seq_JUKART_Human1.35437324
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35437324
56NANOG_19829295_ChIP-Seq_ESCs_Human1.33117915
57SOX2_19829295_ChIP-Seq_ESCs_Human1.33117915
58SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31615433
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30646044
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30025953
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29727689
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29550281
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.28811855
64STAT3_23295773_ChIP-Seq_U87_Human1.28794669
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28630675
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27466478
67CDX2_22108803_ChIP-Seq_LS180_Human1.27394506
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26579253
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26398431
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26362851
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26044056
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25639841
73TCF4_22108803_ChIP-Seq_LS180_Human1.25155756
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24417225
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23095758
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.22228302
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21478965
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.21309332
79AR_25329375_ChIP-Seq_VCAP_Human1.20530019
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20462693
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20205174
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19644592
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18270229
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.17078704
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15627029
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.13603907
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11826612
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11448584
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10326712
90ETV1_20927104_ChIP-Seq_GIST48_Human1.09998771
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09590675
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09427967
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08943962
94TCF4_23295773_ChIP-Seq_U87_Human1.08573021
95TP53_22573176_ChIP-Seq_HFKS_Human1.08237023
96RBPJ_21746931_ChIP-Seq_IB4_Human1.07673101
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.07488022
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06779954
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.06619494
100NFYB_21822215_ChIP-Seq_K562_Human1.05471324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.60753652
2MP0002938_white_spotting3.10471678
3MP0005174_abnormal_tail_pigmentation3.03914423
4MP0002254_reproductive_system_inflammat3.03725765
5MP0008877_abnormal_DNA_methylation2.99187213
6MP0008057_abnormal_DNA_replication2.98990058
7MP0000569_abnormal_digit_pigmentation2.97834081
8MP0008058_abnormal_DNA_repair2.89529416
9MP0003787_abnormal_imprinting2.69123582
10MP0010094_abnormal_chromosome_stability2.58165949
11MP0003195_calcinosis2.33578714
12MP0005075_abnormal_melanosome_morpholog2.19339916
13MP0000015_abnormal_ear_pigmentation2.17341355
14MP0005171_absent_coat_pigmentation2.06957580
15MP0005670_abnormal_white_adipose2.02312002
16MP0003950_abnormal_plasma_membrane1.99935859
17MP0000516_abnormal_urinary_system1.86608417
18MP0005367_renal/urinary_system_phenotyp1.86608417
19MP0005551_abnormal_eye_electrophysiolog1.76818026
20MP0003136_yellow_coat_color1.75123930
21MP0000427_abnormal_hair_cycle1.66804068
22MP0000371_diluted_coat_color1.57990784
23MP0003718_maternal_effect1.57875659
24MP0002095_abnormal_skin_pigmentation1.57749391
25MP0005253_abnormal_eye_physiology1.57627558
26MP0006054_spinal_hemorrhage1.56313441
27MP0002653_abnormal_ependyma_morphology1.56107001
28MP0000613_abnormal_salivary_gland1.51841977
29MP0002163_abnormal_gland_morphology1.49423833
30MP0003943_abnormal_hepatobiliary_system1.48283302
31MP0003880_abnormal_central_pattern1.45776840
32MP0005084_abnormal_gallbladder_morpholo1.44516503
33MP0002735_abnormal_chemical_nociception1.44127067
34MP0003786_premature_aging1.38952506
35MP0008872_abnormal_physiological_respon1.37103365
36MP0002638_abnormal_pupillary_reflex1.34536097
37MP0005379_endocrine/exocrine_gland_phen1.27446154
38MP0001485_abnormal_pinna_reflex1.22408491
39MP0003121_genomic_imprinting1.21327710
40MP0004381_abnormal_hair_follicle1.19725365
41MP0001929_abnormal_gametogenesis1.18098108
42MP0006036_abnormal_mitochondrial_physio1.17945486
43MP0006292_abnormal_olfactory_placode1.14192660
44MP0005310_abnormal_salivary_gland1.13244983
45MP0002876_abnormal_thyroid_physiology1.12911611
46MP0002282_abnormal_trachea_morphology1.10682250
47MP0002277_abnormal_respiratory_mucosa1.10009631
48MP0002138_abnormal_hepatobiliary_system1.09007964
49MP0003186_abnormal_redox_activity1.06970235
50MP0005408_hypopigmentation1.05778312
51MP0008995_early_reproductive_senescence1.05515549
52MP0005365_abnormal_bile_salt1.03724411
53MP0002837_dystrophic_cardiac_calcinosis1.03324165
54MP0000685_abnormal_immune_system1.03000136
55MP0005389_reproductive_system_phenotype1.02468592
56MP0006072_abnormal_retinal_apoptosis1.00372374
57MP0004215_abnormal_myocardial_fiber0.98619268
58MP0001119_abnormal_female_reproductive0.97938963
59MP0004264_abnormal_extraembryonic_tissu0.97504359
60MP0001501_abnormal_sleep_pattern0.96744190
61MP0008007_abnormal_cellular_replicative0.95956243
62MP0002751_abnormal_autonomic_nervous0.95081197
63MP0001145_abnormal_male_reproductive0.94693584
64MP0000653_abnormal_sex_gland0.94665777
65MP0005647_abnormal_sex_gland0.94436598
66MP0001853_heart_inflammation0.92955145
67MP0009697_abnormal_copulation0.91967703
68MP0000647_abnormal_sebaceous_gland0.91868835
69MP0002210_abnormal_sex_determination0.91032050
70MP0002006_tumorigenesis0.91007085
71MP0003755_abnormal_palate_morphology0.89635837
72MP0009764_decreased_sensitivity_to0.85582094
73MP0001873_stomach_inflammation0.85483738
74MP0005395_other_phenotype0.81918511
75MP0001486_abnormal_startle_reflex0.81637979
76MP0003698_abnormal_male_reproductive0.81124177
77MP0005671_abnormal_response_to0.80492605
78MP0002332_abnormal_exercise_endurance0.76473611
79MP0003011_delayed_dark_adaptation0.76357985
80MP0001764_abnormal_homeostasis0.75801157
81MP0001324_abnormal_eye_pigmentation0.74089707
82MP0001919_abnormal_reproductive_system0.74089525
83MP0002075_abnormal_coat/hair_pigmentati0.73484130
84MP0002928_abnormal_bile_duct0.73170059
85MP0002148_abnormal_hypersensitivity_rea0.71990055
86MP0005248_abnormal_Harderian_gland0.71162865
87MP0002233_abnormal_nose_morphology0.70969415
88MP0002166_altered_tumor_susceptibility0.69476520
89MP0004133_heterotaxia0.68734667
90MP0001835_abnormal_antigen_presentation0.68125164
91MP0001986_abnormal_taste_sensitivity0.67392616
92MP0005085_abnormal_gallbladder_physiolo0.66061634
93MP0003936_abnormal_reproductive_system0.65668551
94MP0003252_abnormal_bile_duct0.65657238
95MP0002090_abnormal_vision0.64553783
96MP0003077_abnormal_cell_cycle0.63433069
97MP0002160_abnormal_reproductive_system0.61025102
98MP0001968_abnormal_touch/_nociception0.59918055
99MP0003191_abnormal_cellular_cholesterol0.58101057
100MP0004885_abnormal_endolymph0.57850970

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.73084316
2Chronic hepatic failure (HP:0100626)3.62596785
3Intestinal atresia (HP:0011100)3.57933508
4True hermaphroditism (HP:0010459)3.33246909
5Abnormality of midbrain morphology (HP:0002418)3.26378330
6Molar tooth sign on MRI (HP:0002419)3.26378330
7Hyperventilation (HP:0002883)3.09961127
8Pancreatic islet-cell hyperplasia (HP:0004510)3.09643010
9Pancreatic cysts (HP:0001737)3.02775471
10Albinism (HP:0001022)3.01142040
11Hypoproteinemia (HP:0003075)2.95167292
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79823074
13Thyroiditis (HP:0100646)2.78038213
14Oligodactyly (hands) (HP:0001180)2.75313324
15Fair hair (HP:0002286)2.67950759
16Abnormality of chromosome stability (HP:0003220)2.67690276
17Pancreatic fibrosis (HP:0100732)2.62480770
18Chromsome breakage (HP:0040012)2.60734973
19Abnormality of the ileum (HP:0001549)2.54564761
20Type I transferrin isoform profile (HP:0003642)2.50594202
21Congenital, generalized hypertrichosis (HP:0004540)2.49999628
22Abnormality of the labia minora (HP:0012880)2.49765784
23Meckel diverticulum (HP:0002245)2.46501007
24Concave nail (HP:0001598)2.42976762
25Congenital stationary night blindness (HP:0007642)2.40120203
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.34780472
27Gaze-evoked nystagmus (HP:0000640)2.33954147
28Abnormality of B cell number (HP:0010975)2.31465653
29B lymphocytopenia (HP:0010976)2.30948434
30Follicular hyperkeratosis (HP:0007502)2.29829833
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.26009662
32Hypoplasia of the fovea (HP:0007750)2.26009662
33Abnormality of the renal cortex (HP:0011035)2.25703060
34Generalized hypopigmentation of hair (HP:0011358)2.25481199
35Sloping forehead (HP:0000340)2.16113099
36Long clavicles (HP:0000890)2.13482695
37Severe combined immunodeficiency (HP:0004430)2.12886531
38Widely spaced teeth (HP:0000687)2.12130826
39Limb hypertonia (HP:0002509)2.09427882
40Male pseudohermaphroditism (HP:0000037)2.00290085
41Abnormality of endocrine pancreas physiology (HP:0012093)1.99799693
42Abnormality of the pancreatic islet cells (HP:0006476)1.99799693
43Progressive macrocephaly (HP:0004481)1.99329219
44Increased corneal curvature (HP:0100692)1.99071721
45Keratoconus (HP:0000563)1.99071721
46Nephronophthisis (HP:0000090)1.98664492
47Abnormality of the renal medulla (HP:0100957)1.97825971
48Small hand (HP:0200055)1.97221861
49Duplicated collecting system (HP:0000081)1.97120221
50Clubbing of toes (HP:0100760)1.96613473
51Stomatitis (HP:0010280)1.96389342
52Tubular atrophy (HP:0000092)1.95523322
53Breast carcinoma (HP:0003002)1.95028318
54Hemiparesis (HP:0001269)1.92988397
55Abnormality of the preputium (HP:0100587)1.92629158
56Tented upper lip vermilion (HP:0010804)1.92410764
57Abnormality of the fovea (HP:0000493)1.89403399
58Abnormality of the duodenum (HP:0002246)1.88384152
59Duodenal stenosis (HP:0100867)1.87829988
60Small intestinal stenosis (HP:0012848)1.87829988
61Hypochromic microcytic anemia (HP:0004840)1.84908635
62Polydipsia (HP:0001959)1.83976318
63Abnormal drinking behavior (HP:0030082)1.83976318
64Oligodactyly (HP:0012165)1.83388607
65Ketoacidosis (HP:0001993)1.83071830
66Patchy hypopigmentation of hair (HP:0011365)1.80725729
67Aqueductal stenosis (HP:0002410)1.80528289
68Stomach cancer (HP:0012126)1.80193611
69Hypoplasia of the thymus (HP:0000778)1.77923155
70Pendular nystagmus (HP:0012043)1.77289001
71Abnormal protein glycosylation (HP:0012346)1.77228846
72Abnormal glycosylation (HP:0012345)1.77228846
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77228846
74Abnormal protein N-linked glycosylation (HP:0012347)1.77228846
75Congenital sensorineural hearing impairment (HP:0008527)1.76755405
76Absent speech (HP:0001344)1.76467013
77Abnormality of the renal collecting system (HP:0004742)1.75949394
78Combined immunodeficiency (HP:0005387)1.75638727
79Abolished electroretinogram (ERG) (HP:0000550)1.75490881
80Cutaneous melanoma (HP:0012056)1.75005065
81Attenuation of retinal blood vessels (HP:0007843)1.74741284
82Hypobetalipoproteinemia (HP:0003563)1.74731953
83Ectopic kidney (HP:0000086)1.74585843
84Increased CSF lactate (HP:0002490)1.73017415
85Furrowed tongue (HP:0000221)1.73000743
86Hypoplastic iliac wings (HP:0002866)1.71939654
87Hypothermia (HP:0002045)1.71896497
88Abnormal biliary tract physiology (HP:0012439)1.70857746
89Bile duct proliferation (HP:0001408)1.70857746
903-Methylglutaconic aciduria (HP:0003535)1.69516890
91Keratitis (HP:0000491)1.68327005
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.66512835
93Alveolar cell carcinoma (HP:0006519)1.65898571
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65263722
95Renal cortical cysts (HP:0000803)1.64570449
96Severe visual impairment (HP:0001141)1.64061894
97Alopecia of scalp (HP:0002293)1.63417246
98Curly hair (HP:0002212)1.62666720
99Ependymoma (HP:0002888)1.62598278
100Congenital hepatic fibrosis (HP:0002612)1.62486611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.78358374
2FRK4.16891020
3PDK24.14821028
4WEE13.36292678
5MST43.19992033
6INSRR2.91362426
7BRSK22.80856928
8EIF2AK32.79821213
9TNIK2.57390094
10MKNK22.49655072
11WNK32.04444492
12PNCK1.98636109
13GRK11.94027697
14EIF2AK11.90609732
15BMPR1B1.85090233
16NUAK11.74807577
17STK391.71105313
18EPHA41.65355567
19OXSR11.51287018
20SIK31.48668862
21MAP4K21.44449043
22MKNK11.43278726
23STK31.34791821
24ERBB31.34554392
25TSSK61.34541146
26PLK31.30887392
27PAK31.28413013
28BCR1.22948957
29CASK1.20432097
30MARK31.19930629
31ACVR1B1.18998182
32ADRBK21.18072149
33MAPKAPK31.14087033
34BRSK11.08751341
35MAPK131.08238846
36PBK1.07429335
37PLK21.06820947
38BUB11.03641920
39FGFR21.01522100
40ZAK1.01404991
41STK38L1.00108671
42FER0.98832430
43STK100.87259303
44EIF2AK20.86741607
45NEK60.85777571
46AKT30.82822481
47TAOK10.76085885
48MAP3K120.69211517
49WNK40.69126194
50CCNB10.67982292
51PTK2B0.60178807
52TGFBR10.59601171
53NLK0.59501686
54PLK10.59018055
55NEK10.58004551
56MAP3K40.57760031
57PRKCE0.57574773
58IRAK10.56243161
59IKBKB0.55309431
60TXK0.53760142
61PLK40.53480637
62VRK10.53140921
63BMPR20.52973176
64PRKCI0.52377313
65LATS10.49968559
66TGFBR20.49873297
67PRKCG0.46056354
68ADRBK10.45140656
69IGF1R0.43966537
70PKN10.43787790
71TTK0.41265291
72STK240.39275997
73ATM0.39049922
74PINK10.38894341
75PIK3CA0.34959016
76TEC0.32869279
77ATR0.32643253
78ROCK10.32427292
79CDK30.31874495
80CSNK1G10.31835192
81GRK70.31599833
82SRPK10.31098359
83MUSK0.30870211
84DAPK10.29710331
85ITK0.29535382
86CSNK1G20.29356158
87CHUK0.29184110
88TAF10.28731543
89KSR10.28266525
90ABL10.26730295
91PRKCQ0.26299141
92MINK10.26285308
93NTRK30.26271191
94PIK3CG0.25070699
95IRAK40.24923610
96DYRK30.24255724
97CSNK2A10.24133600
98IKBKE0.24080148
99YES10.23989644
100SGK20.23087069

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.65345243
2Protein export_Homo sapiens_hsa030603.29896926
3Proteasome_Homo sapiens_hsa030502.77361407
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76087993
5Fanconi anemia pathway_Homo sapiens_hsa034602.69282770
6Homologous recombination_Homo sapiens_hsa034402.52826088
7Phototransduction_Homo sapiens_hsa047442.39027641
8Basal transcription factors_Homo sapiens_hsa030222.25029752
9Nitrogen metabolism_Homo sapiens_hsa009102.24951178
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18685321
11Propanoate metabolism_Homo sapiens_hsa006402.12079255
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.00486713
13Butanoate metabolism_Homo sapiens_hsa006501.69960070
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69637474
15Caffeine metabolism_Homo sapiens_hsa002321.67914015
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67293489
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62795347
18RNA degradation_Homo sapiens_hsa030181.53242419
19Asthma_Homo sapiens_hsa053101.52200441
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48672660
21Selenocompound metabolism_Homo sapiens_hsa004501.42525984
22RNA polymerase_Homo sapiens_hsa030201.40676433
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39677790
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31794047
25p53 signaling pathway_Homo sapiens_hsa041151.31043059
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26221523
27Primary immunodeficiency_Homo sapiens_hsa053401.20024000
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15532302
29Tryptophan metabolism_Homo sapiens_hsa003801.15136773
30Legionellosis_Homo sapiens_hsa051341.13011658
31Olfactory transduction_Homo sapiens_hsa047401.11131066
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.08781169
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06136551
34Ether lipid metabolism_Homo sapiens_hsa005651.04371808
35Linoleic acid metabolism_Homo sapiens_hsa005911.04222535
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.02776527
37Histidine metabolism_Homo sapiens_hsa003400.97252462
38Steroid biosynthesis_Homo sapiens_hsa001000.97034133
39Dorso-ventral axis formation_Homo sapiens_hsa043200.95407118
40TGF-beta signaling pathway_Homo sapiens_hsa043500.94094405
41Nucleotide excision repair_Homo sapiens_hsa034200.93833892
42Fat digestion and absorption_Homo sapiens_hsa049750.89799176
43Collecting duct acid secretion_Homo sapiens_hsa049660.88827828
44Glycerolipid metabolism_Homo sapiens_hsa005610.88203638
45Oxidative phosphorylation_Homo sapiens_hsa001900.87823536
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80012557
47Vitamin digestion and absorption_Homo sapiens_hsa049770.79745258
48Regulation of autophagy_Homo sapiens_hsa041400.79516398
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.79173071
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77871985
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77855951
52beta-Alanine metabolism_Homo sapiens_hsa004100.76736997
53Fatty acid elongation_Homo sapiens_hsa000620.75997981
54Allograft rejection_Homo sapiens_hsa053300.75890013
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.75226236
56Mismatch repair_Homo sapiens_hsa034300.73834776
57Peroxisome_Homo sapiens_hsa041460.73375022
58Cell cycle_Homo sapiens_hsa041100.71602933
59Chemical carcinogenesis_Homo sapiens_hsa052040.71547700
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70338840
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69431901
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66818249
63Measles_Homo sapiens_hsa051620.65972016
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65177331
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63472902
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62400371
67Retinol metabolism_Homo sapiens_hsa008300.61726777
68Parkinsons disease_Homo sapiens_hsa050120.61420775
69Lysine degradation_Homo sapiens_hsa003100.61242825
70Sphingolipid metabolism_Homo sapiens_hsa006000.59935141
71RNA transport_Homo sapiens_hsa030130.59640287
72Circadian rhythm_Homo sapiens_hsa047100.59169487
73Autoimmune thyroid disease_Homo sapiens_hsa053200.55851373
74Complement and coagulation cascades_Homo sapiens_hsa046100.54670968
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54404513
76Fatty acid metabolism_Homo sapiens_hsa012120.54004715
77Type I diabetes mellitus_Homo sapiens_hsa049400.53047751
78Hematopoietic cell lineage_Homo sapiens_hsa046400.52068936
79Fatty acid degradation_Homo sapiens_hsa000710.51228617
80Oocyte meiosis_Homo sapiens_hsa041140.49525633
81Vitamin B6 metabolism_Homo sapiens_hsa007500.47985252
82PPAR signaling pathway_Homo sapiens_hsa033200.47439410
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46714675
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45877679
85African trypanosomiasis_Homo sapiens_hsa051430.45156186
86Purine metabolism_Homo sapiens_hsa002300.43710082
87Arginine and proline metabolism_Homo sapiens_hsa003300.43675813
88Glutathione metabolism_Homo sapiens_hsa004800.43401536
89Graft-versus-host disease_Homo sapiens_hsa053320.42939436
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41937698
91Huntingtons disease_Homo sapiens_hsa050160.39800834
92FoxO signaling pathway_Homo sapiens_hsa040680.39709155
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39360969
94Metabolic pathways_Homo sapiens_hsa011000.38008012
95Sulfur metabolism_Homo sapiens_hsa009200.36324360
96Mineral absorption_Homo sapiens_hsa049780.36080965
97Taste transduction_Homo sapiens_hsa047420.34102106
98T cell receptor signaling pathway_Homo sapiens_hsa046600.34068738
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32588114
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30762600

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