EIF4EP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.33525627
2cullin deneddylation (GO:0010388)4.85825938
3protein deneddylation (GO:0000338)4.51721950
4proteasome assembly (GO:0043248)4.48054552
5maturation of 5.8S rRNA (GO:0000460)4.41310192
6protein neddylation (GO:0045116)4.31036641
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.23867912
8regulation of mitotic spindle checkpoint (GO:1903504)4.23867912
9RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.23682868
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.89786327
11water-soluble vitamin biosynthetic process (GO:0042364)3.74983830
12DNA damage response, detection of DNA damage (GO:0042769)3.74305108
13chromatin remodeling at centromere (GO:0031055)3.71517284
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.68999877
15somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.68999877
16isotype switching (GO:0045190)3.68999877
17DNA catabolic process, exonucleolytic (GO:0000738)3.66163716
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65628339
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65282074
20CENP-A containing nucleosome assembly (GO:0034080)3.52976146
21DNA replication checkpoint (GO:0000076)3.48813033
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45575254
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45575254
24respiratory chain complex IV assembly (GO:0008535)3.41135811
25peptidyl-histidine modification (GO:0018202)3.40951687
26ribosome assembly (GO:0042255)3.39768690
27negative regulation of DNA recombination (GO:0045910)3.38702866
28branched-chain amino acid catabolic process (GO:0009083)3.38393167
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.37490999
30IMP biosynthetic process (GO:0006188)3.37244936
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36680298
32histone H2A acetylation (GO:0043968)3.35400553
33purine nucleobase biosynthetic process (GO:0009113)3.34462475
34DNA deamination (GO:0045006)3.27344658
35termination of RNA polymerase III transcription (GO:0006386)3.27295644
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.27295644
37DNA ligation (GO:0006266)3.25917336
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22614350
39histone exchange (GO:0043486)3.21325198
40DNA replication-dependent nucleosome organization (GO:0034723)3.19269886
41DNA replication-dependent nucleosome assembly (GO:0006335)3.19269886
42negative regulation of telomere maintenance (GO:0032205)3.16665117
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.13103901
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13103901
45regulation of helicase activity (GO:0051095)3.12419197
46nucleobase biosynthetic process (GO:0046112)3.10408124
47histone mRNA metabolic process (GO:0008334)3.09461580
48regulation of cellular amino acid metabolic process (GO:0006521)3.04937827
49mitochondrial RNA metabolic process (GO:0000959)3.04330018
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03202429
51negative regulation of ligase activity (GO:0051352)3.02528063
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02528063
53mitochondrial respiratory chain complex assembly (GO:0033108)3.02399795
54aldehyde catabolic process (GO:0046185)3.02223447
55establishment of integrated proviral latency (GO:0075713)3.00869609
56ubiquinone metabolic process (GO:0006743)3.00167106
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94585617
58telomere maintenance via telomerase (GO:0007004)2.91409317
59protein complex biogenesis (GO:0070271)2.91330834
60IMP metabolic process (GO:0046040)2.90752169
61rRNA modification (GO:0000154)2.90729234
62pseudouridine synthesis (GO:0001522)2.90617008
63ubiquinone biosynthetic process (GO:0006744)2.90355090
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.89834520
65NADH dehydrogenase complex assembly (GO:0010257)2.89834520
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89834520
67regulation of centriole replication (GO:0046599)2.89245935
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88304996
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88304996
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88304996
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87568160
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.85539560
73lactate metabolic process (GO:0006089)2.82442452
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82347073
75synapsis (GO:0007129)2.80762408
76replication fork processing (GO:0031297)2.80702217
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80098348
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80098348
79non-recombinational repair (GO:0000726)2.78169071
80double-strand break repair via nonhomologous end joining (GO:0006303)2.78169071
81response to pheromone (GO:0019236)2.77727646
82platelet dense granule organization (GO:0060155)2.76767880
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.75783526
84cytochrome complex assembly (GO:0017004)2.74800446
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.72124614
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72124614
87tRNA metabolic process (GO:0006399)2.71253636
88somatic diversification of immunoglobulins (GO:0016445)2.71114708
89DNA replication-independent nucleosome assembly (GO:0006336)2.69657177
90DNA replication-independent nucleosome organization (GO:0034724)2.69657177
91protein-cofactor linkage (GO:0018065)2.69242383
92tRNA processing (GO:0008033)2.67908978
93regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67775690
94rRNA methylation (GO:0031167)2.67754317
95cholesterol biosynthetic process (GO:0006695)2.66949345
96somatic recombination of immunoglobulin gene segments (GO:0016447)2.66680057
97isoprenoid biosynthetic process (GO:0008299)2.66542468
98sterol biosynthetic process (GO:0016126)2.64101311
99tRNA aminoacylation (GO:0043039)2.63953603
100amino acid activation (GO:0043038)2.63953603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51289095
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.77388962
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.25183856
4ZNF274_21170338_ChIP-Seq_K562_Hela3.17316836
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85349311
6ELK1_19687146_ChIP-ChIP_HELA_Human2.72314662
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67494303
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66309096
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58658255
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53812035
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.49113464
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.48048088
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38939499
14VDR_23849224_ChIP-Seq_CD4+_Human2.36598285
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36509242
16VDR_22108803_ChIP-Seq_LS180_Human2.33189477
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26000066
18EWS_26573619_Chip-Seq_HEK293_Human2.24476215
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.23948831
20IGF1R_20145208_ChIP-Seq_DFB_Human2.22644199
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19091985
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15104061
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14386554
24FUS_26573619_Chip-Seq_HEK293_Human2.07807111
25TAF15_26573619_Chip-Seq_HEK293_Human2.01387617
26FOXP3_21729870_ChIP-Seq_TREG_Human1.95688642
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94664888
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90861575
29E2F7_22180533_ChIP-Seq_HELA_Human1.90420900
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87901566
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82876116
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.73822020
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72976123
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70357832
35P300_19829295_ChIP-Seq_ESCs_Human1.69000042
36MYC_18940864_ChIP-ChIP_HL60_Human1.68030671
37GBX2_23144817_ChIP-Seq_PC3_Human1.66490049
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66005106
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57600414
40DCP1A_22483619_ChIP-Seq_HELA_Human1.57147710
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55607170
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.53307466
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.52390585
44GABP_19822575_ChIP-Seq_HepG2_Human1.45579078
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44923944
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42205128
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40611666
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37012530
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33373911
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31647013
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31242588
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30315058
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30204972
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29615663
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27945881
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.27912836
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24991660
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24638548
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22158190
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18486217
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17514500
62TP53_22573176_ChIP-Seq_HFKS_Human1.17460465
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17295755
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.17082733
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14978407
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.14927704
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13221047
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11537704
69CBP_20019798_ChIP-Seq_JUKART_Human1.11537704
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10853219
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10579186
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10163987
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09791129
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08907634
75ER_23166858_ChIP-Seq_MCF-7_Human1.08811263
76TTF2_22483619_ChIP-Seq_HELA_Human1.08227987
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08005656
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05288985
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.05288985
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04175142
81SOX2_19829295_ChIP-Seq_ESCs_Human1.04062848
82NANOG_19829295_ChIP-Seq_ESCs_Human1.04062848
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04051935
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.01720277
85IRF1_19129219_ChIP-ChIP_H3396_Human1.01104438
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00056006
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.99710628
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98905889
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98636765
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98045550
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96124678
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95087569
93TCF4_22108803_ChIP-Seq_LS180_Human0.93053714
94HTT_18923047_ChIP-ChIP_STHdh_Human0.91640810
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.90695924
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90442640
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89595606
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89124576
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.88979347
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88333045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.72292825
2MP0008058_abnormal_DNA_repair3.64150383
3MP0008877_abnormal_DNA_methylation3.59624791
4MP0010094_abnormal_chromosome_stability3.05358609
5MP0006072_abnormal_retinal_apoptosis2.63502450
6MP0003195_calcinosis2.57135156
7MP0001188_hyperpigmentation2.55889726
8MP0003693_abnormal_embryo_hatching2.50925038
9MP0001529_abnormal_vocalization2.39717483
10MP0003786_premature_aging2.18900130
11MP0004957_abnormal_blastocyst_morpholog2.11843588
12MP0003122_maternal_imprinting2.11013770
13MP0003890_abnormal_embryonic-extraembry2.08333367
14MP0008007_abnormal_cellular_replicative2.04851841
15MP0004147_increased_porphyrin_level2.03665121
16MP0003787_abnormal_imprinting2.02089876
17MP0002837_dystrophic_cardiac_calcinosis2.01762543
18MP0005084_abnormal_gallbladder_morpholo1.98829074
19MP0006035_abnormal_mitochondrial_morpho1.90340495
20MP0003121_genomic_imprinting1.90316674
21MP0002138_abnormal_hepatobiliary_system1.89506448
22MP0003111_abnormal_nucleus_morphology1.86715117
23MP0002751_abnormal_autonomic_nervous1.83262137
24MP0003941_abnormal_skin_development1.77551069
25MP0009697_abnormal_copulation1.77366088
26MP0006054_spinal_hemorrhage1.77318468
27MP0008932_abnormal_embryonic_tissue1.73183875
28MP0003718_maternal_effect1.73052902
29MP0008057_abnormal_DNA_replication1.72168435
30MP0002736_abnormal_nociception_after1.70390907
31MP0000516_abnormal_urinary_system1.66545029
32MP0005367_renal/urinary_system_phenotyp1.66545029
33MP0001984_abnormal_olfaction1.62610173
34MP0000372_irregular_coat_pigmentation1.59363050
35MP0001968_abnormal_touch/_nociception1.59252941
36MP0005253_abnormal_eye_physiology1.58910213
37MP0004215_abnormal_myocardial_fiber1.58493617
38MP0003880_abnormal_central_pattern1.57079919
39MP0003567_abnormal_fetal_cardiomyocyte1.50893523
40MP0006036_abnormal_mitochondrial_physio1.50870946
41MP0005551_abnormal_eye_electrophysiolog1.41467630
42MP0005075_abnormal_melanosome_morpholog1.38208832
43MP0009046_muscle_twitch1.34336601
44MP0008789_abnormal_olfactory_epithelium1.34105052
45MP0003806_abnormal_nucleotide_metabolis1.32884245
46MP0003077_abnormal_cell_cycle1.31446653
47MP0008995_early_reproductive_senescence1.30194741
48MP0003011_delayed_dark_adaptation1.27819133
49MP0006276_abnormal_autonomic_nervous1.23550131
50MP0005645_abnormal_hypothalamus_physiol1.22726231
51MP0001177_atelectasis1.21502763
52MP0001293_anophthalmia1.21497143
53MP0004133_heterotaxia1.20876309
54MP0003137_abnormal_impulse_conducting1.19950200
55MP0002938_white_spotting1.18375370
56MP0005332_abnormal_amino_acid1.13133610
57MP0003119_abnormal_digestive_system1.13056938
58MP0005394_taste/olfaction_phenotype1.11860468
59MP0005499_abnormal_olfactory_system1.11860468
60MP0002638_abnormal_pupillary_reflex1.10335304
61MP0002272_abnormal_nervous_system1.09379362
62MP0008872_abnormal_physiological_respon1.05642591
63MP0003221_abnormal_cardiomyocyte_apopto1.05281747
64MP0001485_abnormal_pinna_reflex1.04703054
65MP0001486_abnormal_startle_reflex1.03423628
66MP0003937_abnormal_limbs/digits/tail_de1.03023800
67MP0002090_abnormal_vision1.02526914
68MP0001929_abnormal_gametogenesis1.02428977
69MP0000647_abnormal_sebaceous_gland1.01145520
70MP0003186_abnormal_redox_activity0.99409941
71MP0004043_abnormal_pH_regulation0.99344478
72MP0010386_abnormal_urinary_bladder0.99087747
73MP0006292_abnormal_olfactory_placode0.97086052
74MP0008875_abnormal_xenobiotic_pharmacok0.93661591
75MP0000358_abnormal_cell_content/0.93505274
76MP0009745_abnormal_behavioral_response0.91223856
77MP0002254_reproductive_system_inflammat0.88279023
78MP0000653_abnormal_sex_gland0.82919941
79MP0002210_abnormal_sex_determination0.81431120
80MP0004085_abnormal_heartbeat0.79499918
81MP0001145_abnormal_male_reproductive0.77713843
82MP0005410_abnormal_fertilization0.75144682
83MP0002734_abnormal_mechanical_nocicepti0.73719505
84MP0002735_abnormal_chemical_nociception0.73018604
85MP0004145_abnormal_muscle_electrophysio0.72406615
86MP0001764_abnormal_homeostasis0.71012414
87MP0002069_abnormal_eating/drinking_beha0.70942831
88MP0005646_abnormal_pituitary_gland0.70722696
89MP0005220_abnormal_exocrine_pancreas0.70535426
90MP0004142_abnormal_muscle_tone0.69607630
91MP0000631_abnormal_neuroendocrine_gland0.68841042
92MP0009703_decreased_birth_body0.68307919
93MP0005266_abnormal_metabolism0.66121532
94MP0002234_abnormal_pharynx_morphology0.64954030
95MP0005379_endocrine/exocrine_gland_phen0.64763559
96MP0000013_abnormal_adipose_tissue0.64710273
97MP0009672_abnormal_birth_weight0.64645580
98MP0003698_abnormal_male_reproductive0.63360434
99MP0008775_abnormal_heart_ventricle0.63194760
100MP0004197_abnormal_fetal_growth/weight/0.63183302

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.82122841
2Methylmalonic acidemia (HP:0002912)3.58332879
3Colon cancer (HP:0003003)3.31191244
4Acute necrotizing encephalopathy (HP:0006965)3.13511263
5Acute encephalopathy (HP:0006846)3.07455077
6Methylmalonic aciduria (HP:0012120)2.98479758
7Pancreatic cysts (HP:0001737)2.80550848
8Increased CSF lactate (HP:0002490)2.77525912
9Hyperglycinemia (HP:0002154)2.75053837
10Abnormal mitochondria in muscle tissue (HP:0008316)2.70114857
11Progressive macrocephaly (HP:0004481)2.69411190
12Abolished electroretinogram (ERG) (HP:0000550)2.66929983
13Hepatic necrosis (HP:0002605)2.65109755
14Pancreatic fibrosis (HP:0100732)2.64751568
15Mitochondrial inheritance (HP:0001427)2.64358315
16Hepatocellular necrosis (HP:0001404)2.61426758
17Medial flaring of the eyebrow (HP:0010747)2.61305976
18Progressive inability to walk (HP:0002505)2.55311473
19Hypothermia (HP:0002045)2.51300979
20True hermaphroditism (HP:0010459)2.51161455
21Abnormality of serum amino acid levels (HP:0003112)2.47204582
22Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42727900
23Abnormality of serine family amino acid metabolism (HP:0010894)2.40815000
24Abnormality of glycine metabolism (HP:0010895)2.40815000
25Increased serum lactate (HP:0002151)2.37040296
26Meckel diverticulum (HP:0002245)2.36866621
27Increased serum pyruvate (HP:0003542)2.35417385
28Abnormality of the ileum (HP:0001549)2.33675766
29Neoplasm of the adrenal gland (HP:0100631)2.32810040
30Abnormality of methionine metabolism (HP:0010901)2.31353643
31Abnormality of chromosome stability (HP:0003220)2.31089455
32Abnormality of vitamin B metabolism (HP:0004340)2.30483322
33Molar tooth sign on MRI (HP:0002419)2.30137254
34Abnormality of midbrain morphology (HP:0002418)2.30137254
35Increased hepatocellular lipid droplets (HP:0006565)2.27478523
36Nephronophthisis (HP:0000090)2.26765754
37Lipid accumulation in hepatocytes (HP:0006561)2.26437136
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25494216
39Abnormal protein N-linked glycosylation (HP:0012347)2.25494216
40Abnormal protein glycosylation (HP:0012346)2.25494216
41Abnormal glycosylation (HP:0012345)2.25494216
42Intestinal atresia (HP:0011100)2.24321966
43Type I transferrin isoform profile (HP:0003642)2.23735915
44Cerebral edema (HP:0002181)2.22602342
45Abnormality of alanine metabolism (HP:0010916)2.21790541
46Hyperalaninemia (HP:0003348)2.21790541
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21790541
48Lactic acidosis (HP:0003128)2.17713242
49Abnormality of glycolysis (HP:0004366)2.16511013
50Hyperglycinuria (HP:0003108)2.14994260
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.14423856
52Hypoglycemic coma (HP:0001325)2.14145450
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.12862462
54Abnormal hair whorl (HP:0010721)2.12827550
55Degeneration of anterior horn cells (HP:0002398)2.11854813
56Abnormality of the anterior horn cell (HP:0006802)2.11854813
57Congenital, generalized hypertrichosis (HP:0004540)2.11555049
58Multiple enchondromatosis (HP:0005701)2.11554994
59Congenital primary aphakia (HP:0007707)2.10854541
60Tongue fasciculations (HP:0001308)2.09636443
61Lethargy (HP:0001254)2.08788938
62Nephrogenic diabetes insipidus (HP:0009806)2.06649633
63Volvulus (HP:0002580)2.06579132
64Pendular nystagmus (HP:0012043)2.05053438
65Ependymoma (HP:0002888)2.03940492
66Gait imbalance (HP:0002141)2.03871568
67Bile duct proliferation (HP:0001408)1.95728392
68Abnormal biliary tract physiology (HP:0012439)1.95728392
69Renal cortical cysts (HP:0000803)1.94573401
70Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94351747
71Abnormality of the preputium (HP:0100587)1.94167623
72Genital tract atresia (HP:0001827)1.91380368
73Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89457143
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89457143
75Abnormality of the renal cortex (HP:0011035)1.87954430
76Pancreatic islet-cell hyperplasia (HP:0004510)1.87118817
77Lissencephaly (HP:0001339)1.86288302
78Sloping forehead (HP:0000340)1.86107227
79Inability to walk (HP:0002540)1.85253203
80Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84647701
81Hyperinsulinemic hypoglycemia (HP:0000825)1.84436525
82Hypomagnesemia (HP:0002917)1.84344109
83Abnormal lung lobation (HP:0002101)1.83744785
84Failure to thrive in infancy (HP:0001531)1.82210719
85Congenital stationary night blindness (HP:0007642)1.81825916
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.81155259
87Duodenal stenosis (HP:0100867)1.79003137
88Small intestinal stenosis (HP:0012848)1.79003137
89Vaginal atresia (HP:0000148)1.78449818
90Optic disc pallor (HP:0000543)1.78108949
91Abnormality of the duodenum (HP:0002246)1.78098815
92Abnormality of the pons (HP:0007361)1.77525263
93Abnormality of the renal medulla (HP:0100957)1.76600459
943-Methylglutaconic aciduria (HP:0003535)1.75715089
95Poor suck (HP:0002033)1.75058337
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.74385782
97Respiratory failure (HP:0002878)1.74087505
98Glioma (HP:0009733)1.73943641
99Cerebral hypomyelination (HP:0006808)1.71977545
100Short tibia (HP:0005736)1.67858709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.19613212
2TSSK63.55570325
3TRIM283.53898427
4MKNK13.02248694
5WNK32.99130500
6BMPR1B2.91614430
7BUB12.52266972
8EIF2AK32.45138018
9ZAK2.43940490
10BCR2.42455880
11NUAK12.33920477
12SRPK12.27788581
13PLK32.27413790
14MAP4K22.20528287
15MST42.18229932
16NEK12.07289717
17TTK1.83736549
18FRK1.79017061
19PLK41.68353007
20TNIK1.64655472
21EIF2AK11.63445372
22MAP3K41.62229490
23ERBB31.60104480
24VRK11.48760972
25PLK21.43916703
26CSNK1G11.39635278
27CSNK1G31.39324589
28BCKDK1.38506697
29STK161.37391577
30TGFBR11.34660753
31VRK21.32565173
32GRK11.30895182
33OXSR11.28694105
34ACVR1B1.27051074
35CSNK1G21.25301250
36CDC71.23910147
37SIK31.23688005
38ADRBK21.20307163
39CSNK1A1L1.07011953
40MAP2K71.06009901
41BRSK20.99179907
42MAPK130.98480219
43PLK10.98249510
44STK38L0.96493148
45RPS6KA40.96102190
46STK390.92417988
47PBK0.83718977
48PINK10.83433400
49DYRK20.82923253
50CASK0.81692536
51CDK80.80963682
52EIF2AK20.78883402
53WEE10.76972449
54TAF10.76606367
55INSRR0.74045830
56ATR0.73771522
57MAP3K120.73287354
58PRKCG0.72164983
59TLK10.70265794
60PRKCE0.69751413
61WNK40.66999235
62ALK0.66373997
63FLT30.65703536
64MINK10.61260959
65DAPK10.56830332
66TIE10.56429683
67NME10.56239858
68PASK0.55207654
69ATM0.54192664
70PAK30.47828876
71FER0.45450434
72EPHA30.42253568
73RPS6KA50.40378343
74LIMK10.40340908
75TEC0.39391504
76DAPK20.39205038
77NLK0.37144954
78CSNK1A10.36880712
79AURKB0.35897157
80CDK30.35801066
81CSNK2A10.33829835
82PHKG10.31821737
83PHKG20.31821737
84CDK90.31795141
85BRSK10.30252158
86CAMK2A0.29296154
87STK30.28980913
88DYRK30.28967612
89CHEK20.28746903
90TXK0.28742773
91CSNK1E0.28656700
92FGFR10.24050587
93DYRK1A0.23995643
94MAP3K50.23444451
95ADRBK10.22830153
96CSNK2A20.22688632
97TAOK30.21168024
98PNCK0.20663514
99CHEK10.20326060
100ERBB40.19625035

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.70174250
2Protein export_Homo sapiens_hsa030603.47785092
3Propanoate metabolism_Homo sapiens_hsa006402.72973139
4Non-homologous end-joining_Homo sapiens_hsa034502.72663394
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50203643
6RNA polymerase_Homo sapiens_hsa030202.45320535
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34120249
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28419558
9Mismatch repair_Homo sapiens_hsa034302.15946803
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15208639
11Steroid biosynthesis_Homo sapiens_hsa001002.13221985
12RNA degradation_Homo sapiens_hsa030182.06864989
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01793755
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99038197
15Basal transcription factors_Homo sapiens_hsa030221.97801837
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93473120
17Oxidative phosphorylation_Homo sapiens_hsa001901.88840055
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85175734
19Fatty acid elongation_Homo sapiens_hsa000621.79870634
20Homologous recombination_Homo sapiens_hsa034401.78700402
21RNA transport_Homo sapiens_hsa030131.76108492
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.67474153
23Butanoate metabolism_Homo sapiens_hsa006501.64149389
24Parkinsons disease_Homo sapiens_hsa050121.62893543
25Fanconi anemia pathway_Homo sapiens_hsa034601.61523977
26Vitamin B6 metabolism_Homo sapiens_hsa007501.51860800
27Pyruvate metabolism_Homo sapiens_hsa006201.51241158
28DNA replication_Homo sapiens_hsa030301.49745667
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44397171
30Base excision repair_Homo sapiens_hsa034101.40179437
31Phototransduction_Homo sapiens_hsa047441.39338751
32Spliceosome_Homo sapiens_hsa030401.34718238
33One carbon pool by folate_Homo sapiens_hsa006701.34462061
34Selenocompound metabolism_Homo sapiens_hsa004501.29509947
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28585114
36Peroxisome_Homo sapiens_hsa041461.27520667
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27257557
38Sulfur metabolism_Homo sapiens_hsa009201.23775846
39Purine metabolism_Homo sapiens_hsa002301.21902275
40Pyrimidine metabolism_Homo sapiens_hsa002401.16735672
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14948951
42Nitrogen metabolism_Homo sapiens_hsa009101.14600815
43Tryptophan metabolism_Homo sapiens_hsa003801.13030013
44Nucleotide excision repair_Homo sapiens_hsa034201.09480090
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05180694
46Huntingtons disease_Homo sapiens_hsa050160.99761925
47beta-Alanine metabolism_Homo sapiens_hsa004100.98433890
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95695251
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93318588
50Collecting duct acid secretion_Homo sapiens_hsa049660.92040750
51Carbon metabolism_Homo sapiens_hsa012000.90960254
52Fatty acid metabolism_Homo sapiens_hsa012120.88140846
53Caffeine metabolism_Homo sapiens_hsa002320.88072696
54Fatty acid degradation_Homo sapiens_hsa000710.87558865
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86526892
56Nicotine addiction_Homo sapiens_hsa050330.85775397
57Ether lipid metabolism_Homo sapiens_hsa005650.82980169
58Biosynthesis of amino acids_Homo sapiens_hsa012300.81567413
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79737311
60Linoleic acid metabolism_Homo sapiens_hsa005910.77670762
61Alzheimers disease_Homo sapiens_hsa050100.76649943
62Metabolic pathways_Homo sapiens_hsa011000.76396351
63Cell cycle_Homo sapiens_hsa041100.76114597
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73924121
65Regulation of autophagy_Homo sapiens_hsa041400.72320955
66Oocyte meiosis_Homo sapiens_hsa041140.71964778
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.70500100
68Folate biosynthesis_Homo sapiens_hsa007900.69580014
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68615975
70Glutathione metabolism_Homo sapiens_hsa004800.66976725
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64051911
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63801460
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59104973
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58736988
75Arginine and proline metabolism_Homo sapiens_hsa003300.58283433
76mRNA surveillance pathway_Homo sapiens_hsa030150.57531616
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.56209735
78Retinol metabolism_Homo sapiens_hsa008300.53055781
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51159753
80GABAergic synapse_Homo sapiens_hsa047270.51145747
81Fat digestion and absorption_Homo sapiens_hsa049750.46675447
82p53 signaling pathway_Homo sapiens_hsa041150.44767977
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43998057
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43869567
85Taste transduction_Homo sapiens_hsa047420.42135626
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39739244
87Chemical carcinogenesis_Homo sapiens_hsa052040.36845728
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34828894
89Asthma_Homo sapiens_hsa053100.34543372
90Arachidonic acid metabolism_Homo sapiens_hsa005900.34365150
91Vitamin digestion and absorption_Homo sapiens_hsa049770.32862040
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32857214
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32232749
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31644191
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31349895
96Synaptic vesicle cycle_Homo sapiens_hsa047210.31274372
97Legionellosis_Homo sapiens_hsa051340.30711875
98Circadian rhythm_Homo sapiens_hsa047100.30279191
99N-Glycan biosynthesis_Homo sapiens_hsa005100.29668630
100Vibrio cholerae infection_Homo sapiens_hsa051100.23089061

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