

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA double-strand break processing (GO:0000729) | 5.33525627 |
| 2 | cullin deneddylation (GO:0010388) | 4.85825938 |
| 3 | protein deneddylation (GO:0000338) | 4.51721950 |
| 4 | proteasome assembly (GO:0043248) | 4.48054552 |
| 5 | maturation of 5.8S rRNA (GO:0000460) | 4.41310192 |
| 6 | protein neddylation (GO:0045116) | 4.31036641 |
| 7 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.23867912 |
| 8 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.23867912 |
| 9 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 4.23682868 |
| 10 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.89786327 |
| 11 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.74983830 |
| 12 | DNA damage response, detection of DNA damage (GO:0042769) | 3.74305108 |
| 13 | chromatin remodeling at centromere (GO:0031055) | 3.71517284 |
| 14 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.68999877 |
| 15 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.68999877 |
| 16 | isotype switching (GO:0045190) | 3.68999877 |
| 17 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.66163716 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.65628339 |
| 19 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.65282074 |
| 20 | CENP-A containing nucleosome assembly (GO:0034080) | 3.52976146 |
| 21 | DNA replication checkpoint (GO:0000076) | 3.48813033 |
| 22 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.45575254 |
| 23 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.45575254 |
| 24 | respiratory chain complex IV assembly (GO:0008535) | 3.41135811 |
| 25 | peptidyl-histidine modification (GO:0018202) | 3.40951687 |
| 26 | ribosome assembly (GO:0042255) | 3.39768690 |
| 27 | negative regulation of DNA recombination (GO:0045910) | 3.38702866 |
| 28 | branched-chain amino acid catabolic process (GO:0009083) | 3.38393167 |
| 29 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.37490999 |
| 30 | IMP biosynthetic process (GO:0006188) | 3.37244936 |
| 31 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.36680298 |
| 32 | histone H2A acetylation (GO:0043968) | 3.35400553 |
| 33 | purine nucleobase biosynthetic process (GO:0009113) | 3.34462475 |
| 34 | DNA deamination (GO:0045006) | 3.27344658 |
| 35 | termination of RNA polymerase III transcription (GO:0006386) | 3.27295644 |
| 36 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.27295644 |
| 37 | DNA ligation (GO:0006266) | 3.25917336 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.22614350 |
| 39 | histone exchange (GO:0043486) | 3.21325198 |
| 40 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.19269886 |
| 41 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.19269886 |
| 42 | negative regulation of telomere maintenance (GO:0032205) | 3.16665117 |
| 43 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.13103901 |
| 44 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.13103901 |
| 45 | regulation of helicase activity (GO:0051095) | 3.12419197 |
| 46 | nucleobase biosynthetic process (GO:0046112) | 3.10408124 |
| 47 | histone mRNA metabolic process (GO:0008334) | 3.09461580 |
| 48 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.04937827 |
| 49 | mitochondrial RNA metabolic process (GO:0000959) | 3.04330018 |
| 50 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.03202429 |
| 51 | negative regulation of ligase activity (GO:0051352) | 3.02528063 |
| 52 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.02528063 |
| 53 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.02399795 |
| 54 | aldehyde catabolic process (GO:0046185) | 3.02223447 |
| 55 | establishment of integrated proviral latency (GO:0075713) | 3.00869609 |
| 56 | ubiquinone metabolic process (GO:0006743) | 3.00167106 |
| 57 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.94585617 |
| 58 | telomere maintenance via telomerase (GO:0007004) | 2.91409317 |
| 59 | protein complex biogenesis (GO:0070271) | 2.91330834 |
| 60 | IMP metabolic process (GO:0046040) | 2.90752169 |
| 61 | rRNA modification (GO:0000154) | 2.90729234 |
| 62 | pseudouridine synthesis (GO:0001522) | 2.90617008 |
| 63 | ubiquinone biosynthetic process (GO:0006744) | 2.90355090 |
| 64 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.89834520 |
| 65 | NADH dehydrogenase complex assembly (GO:0010257) | 2.89834520 |
| 66 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.89834520 |
| 67 | regulation of centriole replication (GO:0046599) | 2.89245935 |
| 68 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.88304996 |
| 69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.88304996 |
| 70 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.88304996 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.87568160 |
| 72 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.85539560 |
| 73 | lactate metabolic process (GO:0006089) | 2.82442452 |
| 74 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.82347073 |
| 75 | synapsis (GO:0007129) | 2.80762408 |
| 76 | replication fork processing (GO:0031297) | 2.80702217 |
| 77 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.80098348 |
| 78 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.80098348 |
| 79 | non-recombinational repair (GO:0000726) | 2.78169071 |
| 80 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.78169071 |
| 81 | response to pheromone (GO:0019236) | 2.77727646 |
| 82 | platelet dense granule organization (GO:0060155) | 2.76767880 |
| 83 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.75783526 |
| 84 | cytochrome complex assembly (GO:0017004) | 2.74800446 |
| 85 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.72124614 |
| 86 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.72124614 |
| 87 | tRNA metabolic process (GO:0006399) | 2.71253636 |
| 88 | somatic diversification of immunoglobulins (GO:0016445) | 2.71114708 |
| 89 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.69657177 |
| 90 | DNA replication-independent nucleosome organization (GO:0034724) | 2.69657177 |
| 91 | protein-cofactor linkage (GO:0018065) | 2.69242383 |
| 92 | tRNA processing (GO:0008033) | 2.67908978 |
| 93 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.67775690 |
| 94 | rRNA methylation (GO:0031167) | 2.67754317 |
| 95 | cholesterol biosynthetic process (GO:0006695) | 2.66949345 |
| 96 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.66680057 |
| 97 | isoprenoid biosynthetic process (GO:0008299) | 2.66542468 |
| 98 | sterol biosynthetic process (GO:0016126) | 2.64101311 |
| 99 | tRNA aminoacylation (GO:0043039) | 2.63953603 |
| 100 | amino acid activation (GO:0043038) | 2.63953603 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.51289095 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.77388962 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.25183856 |
| 4 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.17316836 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.85349311 |
| 6 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.72314662 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.67494303 |
| 8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.66309096 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.58658255 |
| 10 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.53812035 |
| 11 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.49113464 |
| 12 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.48048088 |
| 13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.38939499 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.36598285 |
| 15 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.36509242 |
| 16 | VDR_22108803_ChIP-Seq_LS180_Human | 2.33189477 |
| 17 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.26000066 |
| 18 | EWS_26573619_Chip-Seq_HEK293_Human | 2.24476215 |
| 19 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.23948831 |
| 20 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.22644199 |
| 21 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.19091985 |
| 22 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.15104061 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.14386554 |
| 24 | FUS_26573619_Chip-Seq_HEK293_Human | 2.07807111 |
| 25 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.01387617 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.95688642 |
| 27 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.94664888 |
| 28 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.90861575 |
| 29 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.90420900 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.87901566 |
| 31 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.82876116 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.73822020 |
| 33 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.72976123 |
| 34 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.70357832 |
| 35 | P300_19829295_ChIP-Seq_ESCs_Human | 1.69000042 |
| 36 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.68030671 |
| 37 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.66490049 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.66005106 |
| 39 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.57600414 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.57147710 |
| 41 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.55607170 |
| 42 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.53307466 |
| 43 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.52390585 |
| 44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.45579078 |
| 45 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.44923944 |
| 46 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.42205128 |
| 47 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40611666 |
| 48 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.37012530 |
| 49 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.33373911 |
| 50 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.31647013 |
| 51 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.31242588 |
| 52 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.30315058 |
| 53 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.30204972 |
| 54 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.29615663 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27945881 |
| 56 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.27912836 |
| 57 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.24991660 |
| 58 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.24638548 |
| 59 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.22158190 |
| 60 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.18486217 |
| 61 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.17514500 |
| 62 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.17460465 |
| 63 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.17295755 |
| 64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.17082733 |
| 65 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.14978407 |
| 66 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.14927704 |
| 67 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.13221047 |
| 68 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.11537704 |
| 69 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.11537704 |
| 70 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.10853219 |
| 71 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.10579186 |
| 72 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.10163987 |
| 73 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.09791129 |
| 74 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08907634 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.08811263 |
| 76 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.08227987 |
| 77 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.08005656 |
| 78 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.05288985 |
| 79 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.05288985 |
| 80 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.04175142 |
| 81 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.04062848 |
| 82 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.04062848 |
| 83 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.04051935 |
| 84 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.01720277 |
| 85 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.01104438 |
| 86 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.00056006 |
| 87 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.99710628 |
| 88 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.98905889 |
| 89 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.98636765 |
| 90 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.98045550 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.96124678 |
| 92 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.95087569 |
| 93 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.93053714 |
| 94 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.91640810 |
| 95 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.90695924 |
| 96 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.90442640 |
| 97 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.89595606 |
| 98 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.89124576 |
| 99 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.88979347 |
| 100 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.88333045 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.72292825 |
| 2 | MP0008058_abnormal_DNA_repair | 3.64150383 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.59624791 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.05358609 |
| 5 | MP0006072_abnormal_retinal_apoptosis | 2.63502450 |
| 6 | MP0003195_calcinosis | 2.57135156 |
| 7 | MP0001188_hyperpigmentation | 2.55889726 |
| 8 | MP0003693_abnormal_embryo_hatching | 2.50925038 |
| 9 | MP0001529_abnormal_vocalization | 2.39717483 |
| 10 | MP0003786_premature_aging | 2.18900130 |
| 11 | MP0004957_abnormal_blastocyst_morpholog | 2.11843588 |
| 12 | MP0003122_maternal_imprinting | 2.11013770 |
| 13 | MP0003890_abnormal_embryonic-extraembry | 2.08333367 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.04851841 |
| 15 | MP0004147_increased_porphyrin_level | 2.03665121 |
| 16 | MP0003787_abnormal_imprinting | 2.02089876 |
| 17 | MP0002837_dystrophic_cardiac_calcinosis | 2.01762543 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 1.98829074 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.90340495 |
| 20 | MP0003121_genomic_imprinting | 1.90316674 |
| 21 | MP0002138_abnormal_hepatobiliary_system | 1.89506448 |
| 22 | MP0003111_abnormal_nucleus_morphology | 1.86715117 |
| 23 | MP0002751_abnormal_autonomic_nervous | 1.83262137 |
| 24 | MP0003941_abnormal_skin_development | 1.77551069 |
| 25 | MP0009697_abnormal_copulation | 1.77366088 |
| 26 | MP0006054_spinal_hemorrhage | 1.77318468 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.73183875 |
| 28 | MP0003718_maternal_effect | 1.73052902 |
| 29 | MP0008057_abnormal_DNA_replication | 1.72168435 |
| 30 | MP0002736_abnormal_nociception_after | 1.70390907 |
| 31 | MP0000516_abnormal_urinary_system | 1.66545029 |
| 32 | MP0005367_renal/urinary_system_phenotyp | 1.66545029 |
| 33 | MP0001984_abnormal_olfaction | 1.62610173 |
| 34 | MP0000372_irregular_coat_pigmentation | 1.59363050 |
| 35 | MP0001968_abnormal_touch/_nociception | 1.59252941 |
| 36 | MP0005253_abnormal_eye_physiology | 1.58910213 |
| 37 | MP0004215_abnormal_myocardial_fiber | 1.58493617 |
| 38 | MP0003880_abnormal_central_pattern | 1.57079919 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.50893523 |
| 40 | MP0006036_abnormal_mitochondrial_physio | 1.50870946 |
| 41 | MP0005551_abnormal_eye_electrophysiolog | 1.41467630 |
| 42 | MP0005075_abnormal_melanosome_morpholog | 1.38208832 |
| 43 | MP0009046_muscle_twitch | 1.34336601 |
| 44 | MP0008789_abnormal_olfactory_epithelium | 1.34105052 |
| 45 | MP0003806_abnormal_nucleotide_metabolis | 1.32884245 |
| 46 | MP0003077_abnormal_cell_cycle | 1.31446653 |
| 47 | MP0008995_early_reproductive_senescence | 1.30194741 |
| 48 | MP0003011_delayed_dark_adaptation | 1.27819133 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.23550131 |
| 50 | MP0005645_abnormal_hypothalamus_physiol | 1.22726231 |
| 51 | MP0001177_atelectasis | 1.21502763 |
| 52 | MP0001293_anophthalmia | 1.21497143 |
| 53 | MP0004133_heterotaxia | 1.20876309 |
| 54 | MP0003137_abnormal_impulse_conducting | 1.19950200 |
| 55 | MP0002938_white_spotting | 1.18375370 |
| 56 | MP0005332_abnormal_amino_acid | 1.13133610 |
| 57 | MP0003119_abnormal_digestive_system | 1.13056938 |
| 58 | MP0005394_taste/olfaction_phenotype | 1.11860468 |
| 59 | MP0005499_abnormal_olfactory_system | 1.11860468 |
| 60 | MP0002638_abnormal_pupillary_reflex | 1.10335304 |
| 61 | MP0002272_abnormal_nervous_system | 1.09379362 |
| 62 | MP0008872_abnormal_physiological_respon | 1.05642591 |
| 63 | MP0003221_abnormal_cardiomyocyte_apopto | 1.05281747 |
| 64 | MP0001485_abnormal_pinna_reflex | 1.04703054 |
| 65 | MP0001486_abnormal_startle_reflex | 1.03423628 |
| 66 | MP0003937_abnormal_limbs/digits/tail_de | 1.03023800 |
| 67 | MP0002090_abnormal_vision | 1.02526914 |
| 68 | MP0001929_abnormal_gametogenesis | 1.02428977 |
| 69 | MP0000647_abnormal_sebaceous_gland | 1.01145520 |
| 70 | MP0003186_abnormal_redox_activity | 0.99409941 |
| 71 | MP0004043_abnormal_pH_regulation | 0.99344478 |
| 72 | MP0010386_abnormal_urinary_bladder | 0.99087747 |
| 73 | MP0006292_abnormal_olfactory_placode | 0.97086052 |
| 74 | MP0008875_abnormal_xenobiotic_pharmacok | 0.93661591 |
| 75 | MP0000358_abnormal_cell_content/ | 0.93505274 |
| 76 | MP0009745_abnormal_behavioral_response | 0.91223856 |
| 77 | MP0002254_reproductive_system_inflammat | 0.88279023 |
| 78 | MP0000653_abnormal_sex_gland | 0.82919941 |
| 79 | MP0002210_abnormal_sex_determination | 0.81431120 |
| 80 | MP0004085_abnormal_heartbeat | 0.79499918 |
| 81 | MP0001145_abnormal_male_reproductive | 0.77713843 |
| 82 | MP0005410_abnormal_fertilization | 0.75144682 |
| 83 | MP0002734_abnormal_mechanical_nocicepti | 0.73719505 |
| 84 | MP0002735_abnormal_chemical_nociception | 0.73018604 |
| 85 | MP0004145_abnormal_muscle_electrophysio | 0.72406615 |
| 86 | MP0001764_abnormal_homeostasis | 0.71012414 |
| 87 | MP0002069_abnormal_eating/drinking_beha | 0.70942831 |
| 88 | MP0005646_abnormal_pituitary_gland | 0.70722696 |
| 89 | MP0005220_abnormal_exocrine_pancreas | 0.70535426 |
| 90 | MP0004142_abnormal_muscle_tone | 0.69607630 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.68841042 |
| 92 | MP0009703_decreased_birth_body | 0.68307919 |
| 93 | MP0005266_abnormal_metabolism | 0.66121532 |
| 94 | MP0002234_abnormal_pharynx_morphology | 0.64954030 |
| 95 | MP0005379_endocrine/exocrine_gland_phen | 0.64763559 |
| 96 | MP0000013_abnormal_adipose_tissue | 0.64710273 |
| 97 | MP0009672_abnormal_birth_weight | 0.64645580 |
| 98 | MP0003698_abnormal_male_reproductive | 0.63360434 |
| 99 | MP0008775_abnormal_heart_ventricle | 0.63194760 |
| 100 | MP0004197_abnormal_fetal_growth/weight/ | 0.63183302 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the labia minora (HP:0012880) | 3.82122841 |
| 2 | Methylmalonic acidemia (HP:0002912) | 3.58332879 |
| 3 | Colon cancer (HP:0003003) | 3.31191244 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 3.13511263 |
| 5 | Acute encephalopathy (HP:0006846) | 3.07455077 |
| 6 | Methylmalonic aciduria (HP:0012120) | 2.98479758 |
| 7 | Pancreatic cysts (HP:0001737) | 2.80550848 |
| 8 | Increased CSF lactate (HP:0002490) | 2.77525912 |
| 9 | Hyperglycinemia (HP:0002154) | 2.75053837 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.70114857 |
| 11 | Progressive macrocephaly (HP:0004481) | 2.69411190 |
| 12 | Abolished electroretinogram (ERG) (HP:0000550) | 2.66929983 |
| 13 | Hepatic necrosis (HP:0002605) | 2.65109755 |
| 14 | Pancreatic fibrosis (HP:0100732) | 2.64751568 |
| 15 | Mitochondrial inheritance (HP:0001427) | 2.64358315 |
| 16 | Hepatocellular necrosis (HP:0001404) | 2.61426758 |
| 17 | Medial flaring of the eyebrow (HP:0010747) | 2.61305976 |
| 18 | Progressive inability to walk (HP:0002505) | 2.55311473 |
| 19 | Hypothermia (HP:0002045) | 2.51300979 |
| 20 | True hermaphroditism (HP:0010459) | 2.51161455 |
| 21 | Abnormality of serum amino acid levels (HP:0003112) | 2.47204582 |
| 22 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.42727900 |
| 23 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.40815000 |
| 24 | Abnormality of glycine metabolism (HP:0010895) | 2.40815000 |
| 25 | Increased serum lactate (HP:0002151) | 2.37040296 |
| 26 | Meckel diverticulum (HP:0002245) | 2.36866621 |
| 27 | Increased serum pyruvate (HP:0003542) | 2.35417385 |
| 28 | Abnormality of the ileum (HP:0001549) | 2.33675766 |
| 29 | Neoplasm of the adrenal gland (HP:0100631) | 2.32810040 |
| 30 | Abnormality of methionine metabolism (HP:0010901) | 2.31353643 |
| 31 | Abnormality of chromosome stability (HP:0003220) | 2.31089455 |
| 32 | Abnormality of vitamin B metabolism (HP:0004340) | 2.30483322 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 2.30137254 |
| 34 | Abnormality of midbrain morphology (HP:0002418) | 2.30137254 |
| 35 | Increased hepatocellular lipid droplets (HP:0006565) | 2.27478523 |
| 36 | Nephronophthisis (HP:0000090) | 2.26765754 |
| 37 | Lipid accumulation in hepatocytes (HP:0006561) | 2.26437136 |
| 38 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.25494216 |
| 39 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.25494216 |
| 40 | Abnormal protein glycosylation (HP:0012346) | 2.25494216 |
| 41 | Abnormal glycosylation (HP:0012345) | 2.25494216 |
| 42 | Intestinal atresia (HP:0011100) | 2.24321966 |
| 43 | Type I transferrin isoform profile (HP:0003642) | 2.23735915 |
| 44 | Cerebral edema (HP:0002181) | 2.22602342 |
| 45 | Abnormality of alanine metabolism (HP:0010916) | 2.21790541 |
| 46 | Hyperalaninemia (HP:0003348) | 2.21790541 |
| 47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.21790541 |
| 48 | Lactic acidosis (HP:0003128) | 2.17713242 |
| 49 | Abnormality of glycolysis (HP:0004366) | 2.16511013 |
| 50 | Hyperglycinuria (HP:0003108) | 2.14994260 |
| 51 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.14423856 |
| 52 | Hypoglycemic coma (HP:0001325) | 2.14145450 |
| 53 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.12862462 |
| 54 | Abnormal hair whorl (HP:0010721) | 2.12827550 |
| 55 | Degeneration of anterior horn cells (HP:0002398) | 2.11854813 |
| 56 | Abnormality of the anterior horn cell (HP:0006802) | 2.11854813 |
| 57 | Congenital, generalized hypertrichosis (HP:0004540) | 2.11555049 |
| 58 | Multiple enchondromatosis (HP:0005701) | 2.11554994 |
| 59 | Congenital primary aphakia (HP:0007707) | 2.10854541 |
| 60 | Tongue fasciculations (HP:0001308) | 2.09636443 |
| 61 | Lethargy (HP:0001254) | 2.08788938 |
| 62 | Nephrogenic diabetes insipidus (HP:0009806) | 2.06649633 |
| 63 | Volvulus (HP:0002580) | 2.06579132 |
| 64 | Pendular nystagmus (HP:0012043) | 2.05053438 |
| 65 | Ependymoma (HP:0002888) | 2.03940492 |
| 66 | Gait imbalance (HP:0002141) | 2.03871568 |
| 67 | Bile duct proliferation (HP:0001408) | 1.95728392 |
| 68 | Abnormal biliary tract physiology (HP:0012439) | 1.95728392 |
| 69 | Renal cortical cysts (HP:0000803) | 1.94573401 |
| 70 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.94351747 |
| 71 | Abnormality of the preputium (HP:0100587) | 1.94167623 |
| 72 | Genital tract atresia (HP:0001827) | 1.91380368 |
| 73 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.89457143 |
| 74 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.89457143 |
| 75 | Abnormality of the renal cortex (HP:0011035) | 1.87954430 |
| 76 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.87118817 |
| 77 | Lissencephaly (HP:0001339) | 1.86288302 |
| 78 | Sloping forehead (HP:0000340) | 1.86107227 |
| 79 | Inability to walk (HP:0002540) | 1.85253203 |
| 80 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.84647701 |
| 81 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.84436525 |
| 82 | Hypomagnesemia (HP:0002917) | 1.84344109 |
| 83 | Abnormal lung lobation (HP:0002101) | 1.83744785 |
| 84 | Failure to thrive in infancy (HP:0001531) | 1.82210719 |
| 85 | Congenital stationary night blindness (HP:0007642) | 1.81825916 |
| 86 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.81155259 |
| 87 | Duodenal stenosis (HP:0100867) | 1.79003137 |
| 88 | Small intestinal stenosis (HP:0012848) | 1.79003137 |
| 89 | Vaginal atresia (HP:0000148) | 1.78449818 |
| 90 | Optic disc pallor (HP:0000543) | 1.78108949 |
| 91 | Abnormality of the duodenum (HP:0002246) | 1.78098815 |
| 92 | Abnormality of the pons (HP:0007361) | 1.77525263 |
| 93 | Abnormality of the renal medulla (HP:0100957) | 1.76600459 |
| 94 | 3-Methylglutaconic aciduria (HP:0003535) | 1.75715089 |
| 95 | Poor suck (HP:0002033) | 1.75058337 |
| 96 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.74385782 |
| 97 | Respiratory failure (HP:0002878) | 1.74087505 |
| 98 | Glioma (HP:0009733) | 1.73943641 |
| 99 | Cerebral hypomyelination (HP:0006808) | 1.71977545 |
| 100 | Short tibia (HP:0005736) | 1.67858709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MKNK2 | 4.19613212 |
| 2 | TSSK6 | 3.55570325 |
| 3 | TRIM28 | 3.53898427 |
| 4 | MKNK1 | 3.02248694 |
| 5 | WNK3 | 2.99130500 |
| 6 | BMPR1B | 2.91614430 |
| 7 | BUB1 | 2.52266972 |
| 8 | EIF2AK3 | 2.45138018 |
| 9 | ZAK | 2.43940490 |
| 10 | BCR | 2.42455880 |
| 11 | NUAK1 | 2.33920477 |
| 12 | SRPK1 | 2.27788581 |
| 13 | PLK3 | 2.27413790 |
| 14 | MAP4K2 | 2.20528287 |
| 15 | MST4 | 2.18229932 |
| 16 | NEK1 | 2.07289717 |
| 17 | TTK | 1.83736549 |
| 18 | FRK | 1.79017061 |
| 19 | PLK4 | 1.68353007 |
| 20 | TNIK | 1.64655472 |
| 21 | EIF2AK1 | 1.63445372 |
| 22 | MAP3K4 | 1.62229490 |
| 23 | ERBB3 | 1.60104480 |
| 24 | VRK1 | 1.48760972 |
| 25 | PLK2 | 1.43916703 |
| 26 | CSNK1G1 | 1.39635278 |
| 27 | CSNK1G3 | 1.39324589 |
| 28 | BCKDK | 1.38506697 |
| 29 | STK16 | 1.37391577 |
| 30 | TGFBR1 | 1.34660753 |
| 31 | VRK2 | 1.32565173 |
| 32 | GRK1 | 1.30895182 |
| 33 | OXSR1 | 1.28694105 |
| 34 | ACVR1B | 1.27051074 |
| 35 | CSNK1G2 | 1.25301250 |
| 36 | CDC7 | 1.23910147 |
| 37 | SIK3 | 1.23688005 |
| 38 | ADRBK2 | 1.20307163 |
| 39 | CSNK1A1L | 1.07011953 |
| 40 | MAP2K7 | 1.06009901 |
| 41 | BRSK2 | 0.99179907 |
| 42 | MAPK13 | 0.98480219 |
| 43 | PLK1 | 0.98249510 |
| 44 | STK38L | 0.96493148 |
| 45 | RPS6KA4 | 0.96102190 |
| 46 | STK39 | 0.92417988 |
| 47 | PBK | 0.83718977 |
| 48 | PINK1 | 0.83433400 |
| 49 | DYRK2 | 0.82923253 |
| 50 | CASK | 0.81692536 |
| 51 | CDK8 | 0.80963682 |
| 52 | EIF2AK2 | 0.78883402 |
| 53 | WEE1 | 0.76972449 |
| 54 | TAF1 | 0.76606367 |
| 55 | INSRR | 0.74045830 |
| 56 | ATR | 0.73771522 |
| 57 | MAP3K12 | 0.73287354 |
| 58 | PRKCG | 0.72164983 |
| 59 | TLK1 | 0.70265794 |
| 60 | PRKCE | 0.69751413 |
| 61 | WNK4 | 0.66999235 |
| 62 | ALK | 0.66373997 |
| 63 | FLT3 | 0.65703536 |
| 64 | MINK1 | 0.61260959 |
| 65 | DAPK1 | 0.56830332 |
| 66 | TIE1 | 0.56429683 |
| 67 | NME1 | 0.56239858 |
| 68 | PASK | 0.55207654 |
| 69 | ATM | 0.54192664 |
| 70 | PAK3 | 0.47828876 |
| 71 | FER | 0.45450434 |
| 72 | EPHA3 | 0.42253568 |
| 73 | RPS6KA5 | 0.40378343 |
| 74 | LIMK1 | 0.40340908 |
| 75 | TEC | 0.39391504 |
| 76 | DAPK2 | 0.39205038 |
| 77 | NLK | 0.37144954 |
| 78 | CSNK1A1 | 0.36880712 |
| 79 | AURKB | 0.35897157 |
| 80 | CDK3 | 0.35801066 |
| 81 | CSNK2A1 | 0.33829835 |
| 82 | PHKG1 | 0.31821737 |
| 83 | PHKG2 | 0.31821737 |
| 84 | CDK9 | 0.31795141 |
| 85 | BRSK1 | 0.30252158 |
| 86 | CAMK2A | 0.29296154 |
| 87 | STK3 | 0.28980913 |
| 88 | DYRK3 | 0.28967612 |
| 89 | CHEK2 | 0.28746903 |
| 90 | TXK | 0.28742773 |
| 91 | CSNK1E | 0.28656700 |
| 92 | FGFR1 | 0.24050587 |
| 93 | DYRK1A | 0.23995643 |
| 94 | MAP3K5 | 0.23444451 |
| 95 | ADRBK1 | 0.22830153 |
| 96 | CSNK2A2 | 0.22688632 |
| 97 | TAOK3 | 0.21168024 |
| 98 | PNCK | 0.20663514 |
| 99 | CHEK1 | 0.20326060 |
| 100 | ERBB4 | 0.19625035 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.70174250 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.47785092 |
| 3 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.72973139 |
| 4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.72663394 |
| 5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.50203643 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.45320535 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.34120249 |
| 8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.28419558 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.15946803 |
| 10 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.15208639 |
| 11 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.13221985 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 2.06864989 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.01793755 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.99038197 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97801837 |
| 16 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.93473120 |
| 17 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.88840055 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.85175734 |
| 19 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.79870634 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.78700402 |
| 21 | RNA transport_Homo sapiens_hsa03013 | 1.76108492 |
| 22 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.67474153 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.64149389 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.62893543 |
| 25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.61523977 |
| 26 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.51860800 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.51241158 |
| 28 | DNA replication_Homo sapiens_hsa03030 | 1.49745667 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.44397171 |
| 30 | Base excision repair_Homo sapiens_hsa03410 | 1.40179437 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.39338751 |
| 32 | Spliceosome_Homo sapiens_hsa03040 | 1.34718238 |
| 33 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.34462061 |
| 34 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.29509947 |
| 35 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.28585114 |
| 36 | Peroxisome_Homo sapiens_hsa04146 | 1.27520667 |
| 37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.27257557 |
| 38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.23775846 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.21902275 |
| 40 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.16735672 |
| 41 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.14948951 |
| 42 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.14600815 |
| 43 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.13030013 |
| 44 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.09480090 |
| 45 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.05180694 |
| 46 | Huntingtons disease_Homo sapiens_hsa05016 | 0.99761925 |
| 47 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.98433890 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.95695251 |
| 49 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.93318588 |
| 50 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.92040750 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.90960254 |
| 52 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.88140846 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.88072696 |
| 54 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.87558865 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.86526892 |
| 56 | Nicotine addiction_Homo sapiens_hsa05033 | 0.85775397 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.82980169 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81567413 |
| 59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.79737311 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77670762 |
| 61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.76649943 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76396351 |
| 63 | Cell cycle_Homo sapiens_hsa04110 | 0.76114597 |
| 64 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.73924121 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.72320955 |
| 66 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71964778 |
| 67 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.70500100 |
| 68 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.69580014 |
| 69 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.68615975 |
| 70 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.66976725 |
| 71 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.64051911 |
| 72 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.63801460 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.59104973 |
| 74 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.58736988 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.58283433 |
| 76 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.57531616 |
| 77 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.56209735 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53055781 |
| 79 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.51159753 |
| 80 | GABAergic synapse_Homo sapiens_hsa04727 | 0.51145747 |
| 81 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.46675447 |
| 82 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.44767977 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.43998057 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.43869567 |
| 85 | Taste transduction_Homo sapiens_hsa04742 | 0.42135626 |
| 86 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.39739244 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36845728 |
| 88 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.34828894 |
| 89 | Asthma_Homo sapiens_hsa05310 | 0.34543372 |
| 90 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.34365150 |
| 91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.32862040 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.32857214 |
| 93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.32232749 |
| 94 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.31644191 |
| 95 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.31349895 |
| 96 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.31274372 |
| 97 | Legionellosis_Homo sapiens_hsa05134 | 0.30711875 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.30279191 |
| 99 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.29668630 |
| 100 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.23089061 |

