EIF4EP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)6.02775763
2histone H2A acetylation (GO:0043968)5.91226342
3behavioral response to nicotine (GO:0035095)5.66858401
4phosphate ion transport (GO:0006817)5.01380036
5ubiquinone biosynthetic process (GO:0006744)4.77740018
6quinone biosynthetic process (GO:1901663)4.65252302
7kidney morphogenesis (GO:0060993)4.55240385
8ubiquinone metabolic process (GO:0006743)4.50170767
9urate metabolic process (GO:0046415)4.36570348
10regulation of meiosis I (GO:0060631)4.35761361
11trivalent inorganic anion homeostasis (GO:0072506)4.34147587
12phosphate ion homeostasis (GO:0055062)4.34147587
13proteasome assembly (GO:0043248)4.26106715
14phosphate ion transmembrane transport (GO:0035435)4.06901381
15negative regulation of T-helper cell differentiation (GO:0045623)4.04050258
16negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.04050258
17negative regulation of JAK-STAT cascade (GO:0046426)3.96114889
18response to mercury ion (GO:0046689)3.95312721
19regulation of hippo signaling (GO:0035330)3.91420854
20peptidyl-tyrosine autophosphorylation (GO:0038083)3.73337178
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64936184
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64936184
23negative regulation of meiosis (GO:0045835)3.48767149
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.48439030
25termination of RNA polymerase III transcription (GO:0006386)3.48439030
26pseudouridine synthesis (GO:0001522)3.47795348
27negative regulation of telomere maintenance (GO:0032205)3.45739621
28regulation of isotype switching to IgG isotypes (GO:0048302)3.39928275
29respiratory chain complex IV assembly (GO:0008535)3.36491165
30negative regulation of cAMP-mediated signaling (GO:0043951)3.32775372
31DNA deamination (GO:0045006)3.32463449
32growth hormone receptor signaling pathway (GO:0060396)3.32335791
33negative regulation of meiotic cell cycle (GO:0051447)3.30197743
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23773299
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20364940
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.20364940
37indole-containing compound metabolic process (GO:0042430)3.19994241
38energy homeostasis (GO:0097009)3.17732127
39water-soluble vitamin biosynthetic process (GO:0042364)3.14489602
40tryptophan catabolic process (GO:0006569)3.14391825
41indole-containing compound catabolic process (GO:0042436)3.14391825
42indolalkylamine catabolic process (GO:0046218)3.14391825
43tachykinin receptor signaling pathway (GO:0007217)3.14041841
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.11612195
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11003275
46regulation of immunoglobulin secretion (GO:0051023)3.08123553
47response to growth hormone (GO:0060416)3.03751649
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03434653
49somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.01941044
50isotype switching (GO:0045190)3.01941044
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.01941044
52production of molecular mediator of immune response (GO:0002440)3.00401433
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00292450
54cellular response to growth hormone stimulus (GO:0071378)2.97962116
55cytokine production involved in immune response (GO:0002367)2.97877872
56regulation of podosome assembly (GO:0071801)2.97809998
57negative regulation of alpha-beta T cell differentiation (GO:0046639)2.95115127
58mitochondrial respiratory chain complex I assembly (GO:0032981)2.91292253
59NADH dehydrogenase complex assembly (GO:0010257)2.91292253
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91292253
61energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90297079
62ATP synthesis coupled proton transport (GO:0015986)2.90297079
63regulation of chronic inflammatory response (GO:0002676)2.89485251
64synapsis (GO:0007129)2.87594376
65sulfation (GO:0051923)2.87091157
66regulation of cellular amino acid metabolic process (GO:0006521)2.83665588
67protein complex biogenesis (GO:0070271)2.82140165
68tryptophan metabolic process (GO:0006568)2.77302829
69histone mRNA metabolic process (GO:0008334)2.76533133
70negative regulation of heart rate (GO:0010459)2.76167849
71dopamine transport (GO:0015872)2.75827687
72positive regulation of uterine smooth muscle contraction (GO:0070474)2.71701813
73magnesium ion transport (GO:0015693)2.70352892
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69226967
75cytochrome complex assembly (GO:0017004)2.65570917
76signal peptide processing (GO:0006465)2.64089471
77regulation of dopamine metabolic process (GO:0042053)2.63098211
78regulation of catecholamine metabolic process (GO:0042069)2.63098211
79protein localization to cilium (GO:0061512)2.62749376
80transcription from RNA polymerase III promoter (GO:0006383)2.61801374
81aminoglycoside antibiotic metabolic process (GO:0030647)2.59680775
82glycerol metabolic process (GO:0006071)2.59336335
83glial cell proliferation (GO:0014009)2.58427744
84fucose catabolic process (GO:0019317)2.58393035
85L-fucose metabolic process (GO:0042354)2.58393035
86L-fucose catabolic process (GO:0042355)2.58393035
87isoprenoid biosynthetic process (GO:0008299)2.57252619
88indolalkylamine metabolic process (GO:0006586)2.54211887
89mannosylation (GO:0097502)2.53610033
90cytokine biosynthetic process (GO:0042089)2.53202235
91spliceosomal snRNP assembly (GO:0000387)2.52853023
92T-helper cell differentiation (GO:0042093)2.49379726
93CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.49379726
94branched-chain amino acid catabolic process (GO:0009083)2.48975438
95mitochondrial respiratory chain complex assembly (GO:0033108)2.48931398
96DNA catabolic process, exonucleolytic (GO:0000738)2.48245717
97telomere maintenance via telomerase (GO:0007004)2.48062043
98methionine biosynthetic process (GO:0009086)2.47666744
99regulation of proton transport (GO:0010155)2.47188176
100cardiac right ventricle morphogenesis (GO:0003215)2.45031174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.72444683
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52334459
3ZNF274_21170338_ChIP-Seq_K562_Hela3.35262277
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14746076
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.05962876
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.69135853
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58961099
8VDR_22108803_ChIP-Seq_LS180_Human2.58527064
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47508856
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40895841
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.35230300
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.21618565
13ELK1_19687146_ChIP-ChIP_HELA_Human2.17432796
14FUS_26573619_Chip-Seq_HEK293_Human2.08420392
15EWS_26573619_Chip-Seq_HEK293_Human1.93355780
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.91778874
17MYC_18940864_ChIP-ChIP_HL60_Human1.89108180
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84155871
19VDR_23849224_ChIP-Seq_CD4+_Human1.81706601
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78640393
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.77035457
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70263909
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.67168673
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63963901
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63403822
26ER_23166858_ChIP-Seq_MCF-7_Human1.62240929
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62137453
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60683500
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58179060
30GBX2_23144817_ChIP-Seq_PC3_Human1.51692020
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50378758
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47025597
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45421723
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43499069
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.42853241
36P300_19829295_ChIP-Seq_ESCs_Human1.42194918
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39393417
38IGF1R_20145208_ChIP-Seq_DFB_Human1.38910165
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38597233
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37927773
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37239084
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.36296314
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35364681
44TP53_22573176_ChIP-Seq_HFKS_Human1.34326127
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34171499
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.32689004
47SOX2_19829295_ChIP-Seq_ESCs_Human1.29250445
48NANOG_19829295_ChIP-Seq_ESCs_Human1.29250445
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28214344
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28127285
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27812605
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25049595
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24259822
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22833213
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18477909
56BCAT_22108803_ChIP-Seq_LS180_Human1.18281780
57NCOR_22424771_ChIP-Seq_293T_Human1.16346851
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.16127260
59TCF4_22108803_ChIP-Seq_LS180_Human1.15330138
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.13918451
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12587884
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.12514304
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.11700696
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11065608
65CDX2_22108803_ChIP-Seq_LS180_Human1.10829929
66AR_20517297_ChIP-Seq_VCAP_Human1.10195982
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.09609240
68P300_18555785_Chip-Seq_ESCs_Mouse1.08126464
69FOXP3_21729870_ChIP-Seq_TREG_Human1.07816751
70PHF8_20622853_ChIP-Seq_HELA_Human1.07299835
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07066372
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05585003
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05443670
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04964504
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04916716
76CBP_20019798_ChIP-Seq_JUKART_Human1.04916716
77STAT3_23295773_ChIP-Seq_U87_Human1.04167244
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04108568
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03187347
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02857274
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.02198770
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00810126
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.00566692
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.97819135
85CMYC_18555785_Chip-Seq_ESCs_Mouse0.97659712
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96873207
87RUNX2_22187159_ChIP-Seq_PCA_Human0.96142930
88STAT3_18555785_Chip-Seq_ESCs_Mouse0.96125424
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96123227
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.95277188
91AR_25329375_ChIP-Seq_VCAP_Human0.95063611
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94833082
93ETV1_20927104_ChIP-Seq_GIST48_Human0.93286833
94P53_21459846_ChIP-Seq_SAOS-2_Human0.92676944
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92372755
96P53_22387025_ChIP-Seq_ESCs_Mouse0.92313936
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.91734688
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89947420
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89780066
100GATA3_26560356_Chip-Seq_TH2_Human0.89625482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.71597937
2MP0002138_abnormal_hepatobiliary_system6.92468967
3MP0000538_abnormal_urinary_bladder2.75887685
4MP0001348_abnormal_lacrimal_gland2.58849608
5MP0008875_abnormal_xenobiotic_pharmacok2.49894018
6MP0003195_calcinosis2.33051785
7MP0003878_abnormal_ear_physiology2.19783813
8MP0005377_hearing/vestibular/ear_phenot2.19783813
9MP0008872_abnormal_physiological_respon2.12252525
10MP0006072_abnormal_retinal_apoptosis2.08594412
11MP0003252_abnormal_bile_duct2.01911192
12MP0002837_dystrophic_cardiac_calcinosis1.88936136
13MP0001968_abnormal_touch/_nociception1.88469858
14MP0008058_abnormal_DNA_repair1.88192150
15MP0005645_abnormal_hypothalamus_physiol1.83831722
16MP0004147_increased_porphyrin_level1.81176902
17MP0009333_abnormal_splenocyte_physiolog1.80284747
18MP0000372_irregular_coat_pigmentation1.78398720
19MP0001984_abnormal_olfaction1.76190294
20MP0008877_abnormal_DNA_methylation1.72373141
21MP0003693_abnormal_embryo_hatching1.68289091
22MP0005551_abnormal_eye_electrophysiolog1.61910172
23MP0004043_abnormal_pH_regulation1.56910641
24MP0005332_abnormal_amino_acid1.55045307
25MP0004215_abnormal_myocardial_fiber1.54839736
26MP0001485_abnormal_pinna_reflex1.52433968
27MP0002733_abnormal_thermal_nociception1.46509988
28MP0010386_abnormal_urinary_bladder1.44712464
29MP0002160_abnormal_reproductive_system1.40298668
30MP0010329_abnormal_lipoprotein_level1.38529115
31MP0005310_abnormal_salivary_gland1.31548061
32MP0000569_abnormal_digit_pigmentation1.30489538
33MP0001756_abnormal_urination1.30266763
34MP0004019_abnormal_vitamin_homeostasis1.28770983
35MP0002234_abnormal_pharynx_morphology1.26718207
36MP0005319_abnormal_enzyme/_coenzyme1.24755831
37MP0004145_abnormal_muscle_electrophysio1.22370752
38MP0002638_abnormal_pupillary_reflex1.21416663
39MP0005389_reproductive_system_phenotype1.21110505
40MP0003646_muscle_fatigue1.20470406
41MP0001873_stomach_inflammation1.20075193
42MP0005084_abnormal_gallbladder_morpholo1.18674538
43MP0005253_abnormal_eye_physiology1.18641839
44MP0004133_heterotaxia1.16864304
45MP0010234_abnormal_vibrissa_follicle1.15051507
46MP0003718_maternal_effect1.13752031
47MP0005220_abnormal_exocrine_pancreas1.13537368
48MP0001970_abnormal_pain_threshold1.13218294
49MP0006292_abnormal_olfactory_placode1.13172187
50MP0002736_abnormal_nociception_after1.11640223
51MP0001765_abnormal_ion_homeostasis1.09938087
52MP0002734_abnormal_mechanical_nocicepti1.09808537
53MP0000427_abnormal_hair_cycle1.03385993
54MP0005636_abnormal_mineral_homeostasis1.01352637
55MP0010678_abnormal_skin_adnexa0.99229798
56MP0010094_abnormal_chromosome_stability0.99197191
57MP0009643_abnormal_urine_homeostasis0.98165023
58MP0009765_abnormal_xenobiotic_induced0.95295427
59MP0000613_abnormal_salivary_gland0.94989830
60MP0005085_abnormal_gallbladder_physiolo0.93671056
61MP0002735_abnormal_chemical_nociception0.93223559
62MP0004085_abnormal_heartbeat0.93215336
63MP0001486_abnormal_startle_reflex0.93124185
64MP0003137_abnormal_impulse_conducting0.89444589
65MP0000631_abnormal_neuroendocrine_gland0.89329817
66MP0005167_abnormal_blood-brain_barrier0.88404623
67MP0000383_abnormal_hair_follicle0.88285390
68MP0009745_abnormal_behavioral_response0.88039768
69MP0006054_spinal_hemorrhage0.86278681
70MP0006035_abnormal_mitochondrial_morpho0.84589798
71MP0001545_abnormal_hematopoietic_system0.84496897
72MP0005397_hematopoietic_system_phenotyp0.84496897
73MP0002928_abnormal_bile_duct0.84458644
74MP0003111_abnormal_nucleus_morphology0.84056192
75MP0002751_abnormal_autonomic_nervous0.82354887
76MP0001764_abnormal_homeostasis0.80442159
77MP0003787_abnormal_imprinting0.80328974
78MP0001293_anophthalmia0.79313266
79MP0003283_abnormal_digestive_organ0.79145390
80MP0004134_abnormal_chest_morphology0.78618843
81MP0004957_abnormal_blastocyst_morpholog0.78551730
82MP0005646_abnormal_pituitary_gland0.76327976
83MP0002272_abnormal_nervous_system0.75253947
84MP0003806_abnormal_nucleotide_metabolis0.72276488
85MP0008775_abnormal_heart_ventricle0.72085265
86MP0005671_abnormal_response_to0.71509988
87MP0006082_CNS_inflammation0.71371286
88MP0003880_abnormal_central_pattern0.69502826
89MP0005075_abnormal_melanosome_morpholog0.69045899
90MP0004885_abnormal_endolymph0.68908440
91MP0001501_abnormal_sleep_pattern0.68449065
92MP0009046_muscle_twitch0.68421115
93MP0001835_abnormal_antigen_presentation0.66176534
94MP0001790_abnormal_immune_system0.65700059
95MP0005387_immune_system_phenotype0.65700059
96MP0002166_altered_tumor_susceptibility0.61403211
97MP0009672_abnormal_birth_weight0.59573295
98MP0006036_abnormal_mitochondrial_physio0.59421418
99MP0004510_myositis0.58968212
100MP0001177_atelectasis0.58373196

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)6.35079010
2Pendular nystagmus (HP:0012043)4.95137989
3Congenital stationary night blindness (HP:0007642)4.80080673
4Congenital, generalized hypertrichosis (HP:0004540)4.61188737
5Proximal tubulopathy (HP:0000114)4.45267783
6Pancreatic fibrosis (HP:0100732)4.14551846
7Type I transferrin isoform profile (HP:0003642)4.07166878
8Pancreatic cysts (HP:0001737)3.94390649
9Oral leukoplakia (HP:0002745)3.78921104
10True hermaphroditism (HP:0010459)3.74496232
11Severe visual impairment (HP:0001141)3.73956554
12Reduced antithrombin III activity (HP:0001976)3.72242497
13Abnormal rod and cone electroretinograms (HP:0008323)3.30493586
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.26026760
15Renal cortical cysts (HP:0000803)3.24044953
163-Methylglutaconic aciduria (HP:0003535)3.22854092
17Abolished electroretinogram (ERG) (HP:0000550)3.05394145
18Dry hair (HP:0011359)3.04768333
19Agnosia (HP:0010524)3.01535541
20Increased corneal curvature (HP:0100692)3.01106537
21Keratoconus (HP:0000563)3.01106537
22Severe muscular hypotonia (HP:0006829)2.99809565
23Hepatic necrosis (HP:0002605)2.97439196
24Abnormality of secondary sexual hair (HP:0009888)2.93412748
25Abnormality of the axillary hair (HP:0100134)2.93412748
26Hypoglycemic coma (HP:0001325)2.92802498
27Cystic liver disease (HP:0006706)2.91683494
28Abnormality of the pons (HP:0007361)2.89252728
29Abnormal biliary tract physiology (HP:0012439)2.83724554
30Bile duct proliferation (HP:0001408)2.83724554
31Large for gestational age (HP:0001520)2.82463761
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73528485
33Abnormal protein N-linked glycosylation (HP:0012347)2.73528485
34Abnormal protein glycosylation (HP:0012346)2.73528485
35Abnormal glycosylation (HP:0012345)2.73528485
36Type II lissencephaly (HP:0007260)2.68235820
37Abnormality of the renal cortex (HP:0011035)2.66756412
38Nephronophthisis (HP:0000090)2.62731348
39Tongue fasciculations (HP:0001308)2.59291132
40Glycosuria (HP:0003076)2.54025280
41Abnormality of urine glucose concentration (HP:0011016)2.54025280
42Fair hair (HP:0002286)2.41972183
43Decreased central vision (HP:0007663)2.38834901
44Furrowed tongue (HP:0000221)2.32120333
45Abnormality of the renal medulla (HP:0100957)2.28459988
46Colon cancer (HP:0003003)2.27881862
47Sclerocornea (HP:0000647)2.27072070
48Ependymoma (HP:0002888)2.25856962
49Ridged nail (HP:0001807)2.24491204
50Increased CSF lactate (HP:0002490)2.16675295
51Sparse eyelashes (HP:0000653)2.15811339
52Muscle fibrillation (HP:0010546)2.15411886
53Hypoproteinemia (HP:0003075)2.13886284
54Attenuation of retinal blood vessels (HP:0007843)2.13652509
55Male pseudohermaphroditism (HP:0000037)2.11910788
56Homocystinuria (HP:0002156)2.11881567
57Abnormality of homocysteine metabolism (HP:0010919)2.11881567
58Hepatocellular necrosis (HP:0001404)2.11217962
59Parakeratosis (HP:0001036)2.10060007
60Mitochondrial inheritance (HP:0001427)2.08208249
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.03346211
62Congenital hepatic fibrosis (HP:0002612)2.02540254
63Neonatal respiratory distress (HP:0002643)2.02182766
64Acute necrotizing encephalopathy (HP:0006965)2.00450004
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99656162
66Chorioretinal atrophy (HP:0000533)1.97599632
67Pachygyria (HP:0001302)1.95730789
68Hemiparesis (HP:0001269)1.95681463
69Abnormality of the renal collecting system (HP:0004742)1.95564754
70Nausea (HP:0002018)1.95420212
71Generalized hypopigmentation of hair (HP:0011358)1.94682823
72Hydroxyprolinuria (HP:0003080)1.94626371
73Abnormality of proline metabolism (HP:0010907)1.94626371
74Increased serum lactate (HP:0002151)1.94051325
75Prostate neoplasm (HP:0100787)1.91106029
76Aplastic anemia (HP:0001915)1.90287821
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89853619
78Dicarboxylic aciduria (HP:0003215)1.89853619
79Abnormal pupillary function (HP:0007686)1.89709805
80Optic nerve hypoplasia (HP:0000609)1.89459463
81Congenital sensorineural hearing impairment (HP:0008527)1.88023937
82Type 2 muscle fiber atrophy (HP:0003554)1.84780364
83Hypoplasia of the pons (HP:0012110)1.84034546
84Progressive macrocephaly (HP:0004481)1.83681457
85Anencephaly (HP:0002323)1.83607609
86Progressive muscle weakness (HP:0003323)1.82905711
87Abnormality of vitamin B metabolism (HP:0004340)1.82667869
88Abnormality of placental membranes (HP:0011409)1.82126769
89Amniotic constriction ring (HP:0009775)1.82126769
90Lethargy (HP:0001254)1.82085011
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82045563
92Decreased circulating renin level (HP:0003351)1.80825930
93Abnormality of methionine metabolism (HP:0010901)1.80403996
94Lactic acidosis (HP:0003128)1.80395874
95Hyperphosphaturia (HP:0003109)1.75365191
96Polydipsia (HP:0001959)1.74391938
97Abnormal drinking behavior (HP:0030082)1.74391938
98IgG deficiency (HP:0004315)1.74246653
99Stomach cancer (HP:0012126)1.72480744
100Abnormality of midbrain morphology (HP:0002418)1.71159006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.17747023
2BMPR1B4.13408055
3FRK3.54121879
4PBK3.03347536
5EIF2AK13.00409351
6TNIK2.99337669
7ADRBK22.96656727
8TRIM282.80051935
9TLK12.41994961
10MKNK12.38977849
11EPHA42.30340796
12SRPK12.27643634
13ZAK2.22222061
14TSSK61.98797688
15TGFBR11.96554660
16GRK11.92733809
17EIF2AK31.81050080
18BCKDK1.68863351
19OXSR11.67032000
20STK391.64286616
21MAP4K21.59614040
22MST41.58171380
23BUB11.49713419
24TXK1.48897297
25VRK11.46986389
26PLK31.46302186
27VRK21.44772361
28FLT31.43394843
29PKN21.42484108
30WNK41.42455461
31NME11.33893595
32WNK31.30468124
33TAOK31.25458107
34CDK191.24385024
35ACVR1B1.18639313
36PHKG21.12331668
37PHKG11.12331668
38INSRR1.01595357
39BRD40.99689567
40PINK10.95079043
41MARK30.93181617
42STK38L0.92788692
43CDK80.91831150
44FGFR20.78527830
45TIE10.77590695
46PRKCG0.77557612
47BCR0.75648417
48PLK40.73965333
49MAP2K60.72162040
50GRK50.71479772
51STK40.69662347
52DAPK20.67183602
53ALK0.66707448
54PRKD20.62829709
55NLK0.62420691
56STK30.62151483
57TTK0.61636765
58MAP3K140.61434832
59KIT0.60484828
60PIK3CA0.59305990
61ITK0.58192373
62MAP4K10.57748172
63GRK70.57565136
64PLK10.54404220
65PRKG20.53539813
66PTK2B0.48872293
67TNK20.48124748
68CSNK1G10.47466186
69CCNB10.46479785
70ADRBK10.46146665
71PLK20.46061735
72NEK10.44777769
73PNCK0.43735183
74IKBKB0.42454055
75EIF2AK20.41604542
76AURKA0.41032154
77CSNK1A10.40571976
78MAPK130.40322638
79CLK10.39675105
80ERBB30.39626055
81SYK0.37579206
82DYRK20.36623588
83RPS6KB10.36350901
84CSNK1G30.36132992
85NUAK10.35012774
86MAPKAPK30.34314150
87PRKCE0.34157890
88FGFR10.32225228
89IGF1R0.31716458
90KDR0.31630749
91OBSCN0.30290606
92CDC70.29281250
93CDK140.29109154
94MAP3K40.28478445
95PRKCA0.27930284
96STK160.26562946
97PRKACA0.26233383
98ATM0.23374498
99LCK0.22379285
100CDK60.22028789

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.06642246
2Proteasome_Homo sapiens_hsa030503.37313903
3Asthma_Homo sapiens_hsa053102.92078533
4RNA polymerase_Homo sapiens_hsa030202.77498969
5Phototransduction_Homo sapiens_hsa047442.42968416
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.31874780
7Allograft rejection_Homo sapiens_hsa053302.31171297
8Protein export_Homo sapiens_hsa030602.27676134
9Autoimmune thyroid disease_Homo sapiens_hsa053202.25669575
10Oxidative phosphorylation_Homo sapiens_hsa001902.09251144
11Nitrogen metabolism_Homo sapiens_hsa009102.07056642
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00170438
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99064437
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90119820
15Tryptophan metabolism_Homo sapiens_hsa003801.71999127
16One carbon pool by folate_Homo sapiens_hsa006701.62963136
17Renin-angiotensin system_Homo sapiens_hsa046141.60511437
18Propanoate metabolism_Homo sapiens_hsa006401.56876862
19Butanoate metabolism_Homo sapiens_hsa006501.56296771
20Parkinsons disease_Homo sapiens_hsa050121.53367562
21Sulfur metabolism_Homo sapiens_hsa009201.52093115
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.50536849
23Selenocompound metabolism_Homo sapiens_hsa004501.49550343
24Linoleic acid metabolism_Homo sapiens_hsa005911.47710487
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47408049
26Homologous recombination_Homo sapiens_hsa034401.47178559
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43181548
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41161207
29RNA degradation_Homo sapiens_hsa030181.38445122
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35031490
31Caffeine metabolism_Homo sapiens_hsa002321.30567530
32Taste transduction_Homo sapiens_hsa047421.27149088
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22371948
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17077396
35Non-homologous end-joining_Homo sapiens_hsa034501.15630729
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15129847
37Mismatch repair_Homo sapiens_hsa034301.14506327
38Fatty acid degradation_Homo sapiens_hsa000711.14307706
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13487598
40Retinol metabolism_Homo sapiens_hsa008301.12431378
41Chemical carcinogenesis_Homo sapiens_hsa052041.11887171
42Purine metabolism_Homo sapiens_hsa002301.11085484
43Pyrimidine metabolism_Homo sapiens_hsa002401.10260221
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.08891167
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06823265
46Peroxisome_Homo sapiens_hsa041461.04712090
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98050272
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.96026974
49Fatty acid metabolism_Homo sapiens_hsa012120.92235703
50Spliceosome_Homo sapiens_hsa030400.91340752
51Alzheimers disease_Homo sapiens_hsa050100.89576517
52Vitamin digestion and absorption_Homo sapiens_hsa049770.87943342
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86990473
54Ribosome_Homo sapiens_hsa030100.85585783
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84998526
56RNA transport_Homo sapiens_hsa030130.79909796
57Morphine addiction_Homo sapiens_hsa050320.78424193
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77635834
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77479577
60Type I diabetes mellitus_Homo sapiens_hsa049400.77432779
61Nicotine addiction_Homo sapiens_hsa050330.77202532
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77050970
63Fanconi anemia pathway_Homo sapiens_hsa034600.76215452
64Starch and sucrose metabolism_Homo sapiens_hsa005000.74844116
65Fat digestion and absorption_Homo sapiens_hsa049750.74589617
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74122584
67N-Glycan biosynthesis_Homo sapiens_hsa005100.73758417
68Steroid biosynthesis_Homo sapiens_hsa001000.71474799
69Graft-versus-host disease_Homo sapiens_hsa053320.69737660
70Huntingtons disease_Homo sapiens_hsa050160.68439035
71Histidine metabolism_Homo sapiens_hsa003400.66715893
72beta-Alanine metabolism_Homo sapiens_hsa004100.65219293
73Arachidonic acid metabolism_Homo sapiens_hsa005900.64767239
74Fatty acid elongation_Homo sapiens_hsa000620.63493971
75Metabolic pathways_Homo sapiens_hsa011000.61882474
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60952670
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60553486
78Arginine and proline metabolism_Homo sapiens_hsa003300.57953059
79Glycerolipid metabolism_Homo sapiens_hsa005610.57916780
80Base excision repair_Homo sapiens_hsa034100.54612060
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52546045
82Ovarian steroidogenesis_Homo sapiens_hsa049130.52123074
83Collecting duct acid secretion_Homo sapiens_hsa049660.51899611
84Vitamin B6 metabolism_Homo sapiens_hsa007500.51802289
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51234032
86Pancreatic secretion_Homo sapiens_hsa049720.50438891
87Ether lipid metabolism_Homo sapiens_hsa005650.49131902
88Basal transcription factors_Homo sapiens_hsa030220.49041412
89Glutathione metabolism_Homo sapiens_hsa004800.48320947
90Hematopoietic cell lineage_Homo sapiens_hsa046400.48100701
91Nucleotide excision repair_Homo sapiens_hsa034200.47527340
92Pyruvate metabolism_Homo sapiens_hsa006200.47155518
93Cardiac muscle contraction_Homo sapiens_hsa042600.45725247
94Olfactory transduction_Homo sapiens_hsa047400.43683040
95Rheumatoid arthritis_Homo sapiens_hsa053230.41780199
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40848715
97Salivary secretion_Homo sapiens_hsa049700.40431597
98DNA replication_Homo sapiens_hsa030300.40416323
99Systemic lupus erythematosus_Homo sapiens_hsa053220.39921642
100Serotonergic synapse_Homo sapiens_hsa047260.35755759

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