EIF4EP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.24930637
2cell morphogenesis involved in neuron differentiation (GO:0048667)7.25943825
3folic acid-containing compound biosynthetic process (GO:0009396)6.98564583
4post-embryonic morphogenesis (GO:0009886)6.39676968
5mitochondrial DNA replication (GO:0006264)5.90931473
6synapsis (GO:0007129)5.63385280
7peptidyl-histidine modification (GO:0018202)5.53743369
8cell wall macromolecule catabolic process (GO:0016998)5.37468976
9pteridine-containing compound biosynthetic process (GO:0042559)5.22358743
10resolution of meiotic recombination intermediates (GO:0000712)5.03020084
11chaperone mediated protein folding requiring cofactor (GO:0051085)4.78581970
12folic acid metabolic process (GO:0046655)4.71511942
13intestinal cholesterol absorption (GO:0030299)4.70632685
14cell wall macromolecule metabolic process (GO:0044036)4.48416761
15DNA catabolic process, exonucleolytic (GO:0000738)4.38981323
16negative regulation of gene silencing (GO:0060969)4.36038322
17regulation of posttranscriptional gene silencing (GO:0060147)4.27547597
18regulation of gene silencing by miRNA (GO:0060964)4.27547597
19regulation of gene silencing by RNA (GO:0060966)4.27547597
20cullin deneddylation (GO:0010388)4.14073122
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.98970251
22very-low-density lipoprotein particle assembly (GO:0034379)3.97713076
23oogenesis (GO:0048477)3.97429593
24male meiosis I (GO:0007141)3.97373329
25regulation of podosome assembly (GO:0071801)3.95268734
26protein deneddylation (GO:0000338)3.85964424
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.79997573
28regulation of isotype switching to IgG isotypes (GO:0048302)3.78956691
29DNA double-strand break processing (GO:0000729)3.78161902
30negative regulation of T-helper cell differentiation (GO:0045623)3.77255917
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.77255917
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.74316042
33NADH dehydrogenase complex assembly (GO:0010257)3.74316042
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74316042
35mitochondrial DNA metabolic process (GO:0032042)3.71106713
36platelet dense granule organization (GO:0060155)3.67453236
37pyrimidine-containing compound transmembrane transport (GO:0072531)3.48703989
38mitochondrial respiratory chain complex assembly (GO:0033108)3.43770788
39regulation of chronic inflammatory response (GO:0002676)3.43398349
40short-chain fatty acid metabolic process (GO:0046459)3.37832465
41protein complex biogenesis (GO:0070271)3.31454156
42L-fucose catabolic process (GO:0042355)3.27702714
43fucose catabolic process (GO:0019317)3.27702714
44L-fucose metabolic process (GO:0042354)3.27702714
45regulation of rhodopsin mediated signaling pathway (GO:0022400)3.25230451
46negative regulation of meiotic cell cycle (GO:0051447)3.21819816
47viral mRNA export from host cell nucleus (GO:0046784)3.19316533
48meiosis I (GO:0007127)3.18180394
49DNA-dependent DNA replication (GO:0006261)3.14121538
50tryptophan catabolic process (GO:0006569)3.12665838
51indole-containing compound catabolic process (GO:0042436)3.12665838
52indolalkylamine catabolic process (GO:0046218)3.12665838
53negative regulation of meiosis (GO:0045835)3.11850587
54kidney morphogenesis (GO:0060993)3.09696852
55folic acid-containing compound metabolic process (GO:0006760)3.09188061
56pseudouridine synthesis (GO:0001522)3.06974835
57positive regulation of immunoglobulin production (GO:0002639)3.05737334
58base-excision repair, AP site formation (GO:0006285)3.04308253
59rhodopsin mediated signaling pathway (GO:0016056)3.03864008
60estrogen biosynthetic process (GO:0006703)2.99476567
61S-adenosylmethionine metabolic process (GO:0046500)2.99153222
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.98759742
63signal peptide processing (GO:0006465)2.97002146
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95898067
65negative regulation of activin receptor signaling pathway (GO:0032926)2.94050804
66positive regulation of isotype switching (GO:0045830)2.93177121
67cytokine biosynthetic process (GO:0042089)2.92846750
68positive regulation of DNA recombination (GO:0045911)2.88716234
69long term synaptic depression (GO:0060292)2.88242018
70negative regulation of alpha-beta T cell differentiation (GO:0046639)2.86195933
71replication fork processing (GO:0031297)2.84591008
72negative regulation of cAMP-mediated signaling (GO:0043951)2.80665706
73regulation of macrophage activation (GO:0043030)2.80440623
74CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79494607
75pteridine-containing compound metabolic process (GO:0042558)2.79351223
76defense response to protozoan (GO:0042832)2.79218240
77negative regulation of T cell differentiation (GO:0045581)2.74495732
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.73992880
79T-helper cell differentiation (GO:0042093)2.73992880
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.72554963
81negative regulation of acute inflammatory response (GO:0002674)2.72501363
82negative regulation of B cell apoptotic process (GO:0002903)2.71304795
83regulation of immunoglobulin secretion (GO:0051023)2.70692254
84DNA damage response, detection of DNA damage (GO:0042769)2.69051576
85regulation of meiosis I (GO:0060631)2.67291727
86ATP synthesis coupled proton transport (GO:0015986)2.67262184
87energy coupled proton transport, down electrochemical gradient (GO:0015985)2.67262184
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65268219
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63770593
90female gamete generation (GO:0007292)2.63491547
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63303409
92histone H2A acetylation (GO:0043968)2.62063600
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60842517
94energy homeostasis (GO:0097009)2.60808283
95tryptophan metabolic process (GO:0006568)2.60419954
96behavioral response to nicotine (GO:0035095)2.56559778
97male meiosis (GO:0007140)2.55536967
98response to protozoan (GO:0001562)2.53991681
99sphingosine metabolic process (GO:0006670)2.53142653
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.50839845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97903827
2VDR_22108803_ChIP-Seq_LS180_Human3.93193367
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74771718
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.63052631
5ZNF274_21170338_ChIP-Seq_K562_Hela2.96169967
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.73137186
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.71208275
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58586903
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.53851869
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43602854
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.40773062
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36018125
13VDR_23849224_ChIP-Seq_CD4+_Human2.34562466
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32479565
15TAF15_26573619_Chip-Seq_HEK293_Human2.32033699
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30341928
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12615378
18EWS_26573619_Chip-Seq_HEK293_Human2.06779740
19EZH2_22144423_ChIP-Seq_EOC_Human1.93706207
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92061902
21ELK1_19687146_ChIP-ChIP_HELA_Human1.86830036
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.81162258
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.77136102
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75466792
25MYC_18940864_ChIP-ChIP_HL60_Human1.74503104
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73508885
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72196050
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71181337
29ER_23166858_ChIP-Seq_MCF-7_Human1.70678895
30FUS_26573619_Chip-Seq_HEK293_Human1.68509198
31BCAT_22108803_ChIP-Seq_LS180_Human1.66744574
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66551221
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.61162932
34TP53_22573176_ChIP-Seq_HFKS_Human1.59165804
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57218689
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56599078
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55354394
38NANOG_19829295_ChIP-Seq_ESCs_Human1.53604249
39SOX2_19829295_ChIP-Seq_ESCs_Human1.53604249
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53353868
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53201048
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52892564
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.51690235
44P300_19829295_ChIP-Seq_ESCs_Human1.41920312
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38402004
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.38086519
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37745378
48FOXP3_21729870_ChIP-Seq_TREG_Human1.34067822
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33256619
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30019686
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29452634
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.29028222
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.27701484
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26008097
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25669649
56HOXB7_26014856_ChIP-Seq_BT474_Human1.21866309
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21709218
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20392617
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19767329
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.19767329
61PHF8_20622853_ChIP-Seq_HELA_Human1.19332803
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18064845
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17077919
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.16264979
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15232936
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13996198
67IGF1R_20145208_ChIP-Seq_DFB_Human1.11956911
68CBP_20019798_ChIP-Seq_JUKART_Human1.11466364
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11466364
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09810665
71GATA3_26560356_Chip-Seq_TH2_Human1.08721524
72NCOR_22424771_ChIP-Seq_293T_Human1.06372192
73ETV1_20927104_ChIP-Seq_GIST48_Human1.06309370
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.05824918
75RUNX2_22187159_ChIP-Seq_PCA_Human1.05268603
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05062507
77CDX2_22108803_ChIP-Seq_LS180_Human1.04886742
78RBPJ_21746931_ChIP-Seq_IB4_Human1.03992521
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03026082
80GATA6_21074721_ChIP-Seq_CACO-2_Human1.02671312
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.01790875
82GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01711542
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01119548
84AR_25329375_ChIP-Seq_VCAP_Human1.00573768
85AR_20517297_ChIP-Seq_VCAP_Human0.99885398
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99284870
87DCP1A_22483619_ChIP-Seq_HELA_Human0.97733961
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97644653
89NFYA_21822215_ChIP-Seq_K562_Human0.96137888
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.95684972
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95309148
92SOX2_18555785_Chip-Seq_ESCs_Mouse0.94839130
93MYC_18555785_ChIP-Seq_MESCs_Mouse0.94831298
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.93901806
95NFYB_21822215_ChIP-Seq_K562_Human0.93104335
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92976632
97SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91830949
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91787153
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.90303807
100P300_18555785_Chip-Seq_ESCs_Mouse0.89530858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.25045886
2MP0006072_abnormal_retinal_apoptosis4.79976172
3MP0004147_increased_porphyrin_level3.16854489
4MP0003646_muscle_fatigue3.04459711
5MP0006292_abnormal_olfactory_placode2.89490112
6MP0004043_abnormal_pH_regulation2.67307154
7MP0001873_stomach_inflammation2.39923595
8MP0001348_abnormal_lacrimal_gland2.39636132
9MP0000538_abnormal_urinary_bladder2.35788457
10MP0005253_abnormal_eye_physiology2.29598891
11MP0003806_abnormal_nucleotide_metabolis2.24202595
12MP0001293_anophthalmia2.08373609
13MP0002837_dystrophic_cardiac_calcinosis2.06216212
14MP0001835_abnormal_antigen_presentation2.04425208
15MP0008875_abnormal_xenobiotic_pharmacok2.02985764
16MP0003011_delayed_dark_adaptation2.02419161
17MP0005085_abnormal_gallbladder_physiolo2.01442555
18MP0001790_abnormal_immune_system1.98351021
19MP0005387_immune_system_phenotype1.98351021
20MP0005671_abnormal_response_to1.91842273
21MP0005379_endocrine/exocrine_gland_phen1.87417892
22MP0002138_abnormal_hepatobiliary_system1.82367787
23MP0002163_abnormal_gland_morphology1.77424351
24MP0010329_abnormal_lipoprotein_level1.71628408
25MP0008872_abnormal_physiological_respon1.70274619
26MP0003718_maternal_effect1.62754814
27MP0005332_abnormal_amino_acid1.62318204
28MP0003195_calcinosis1.60811072
29MP0005551_abnormal_eye_electrophysiolog1.60541607
30MP0002009_preneoplasia1.60167381
31MP0003252_abnormal_bile_duct1.59509149
32MP0000685_abnormal_immune_system1.53745446
33MP0002876_abnormal_thyroid_physiology1.51832387
34MP0002909_abnormal_adrenal_gland1.43185243
35MP0002736_abnormal_nociception_after1.32340552
36MP0002166_altered_tumor_susceptibility1.31654581
37MP0005084_abnormal_gallbladder_morpholo1.28564637
38MP0006082_CNS_inflammation1.28012548
39MP0000427_abnormal_hair_cycle1.26222148
40MP0005645_abnormal_hypothalamus_physiol1.25136336
41MP0004885_abnormal_endolymph1.24743349
42MP0005310_abnormal_salivary_gland1.23858271
43MP0002095_abnormal_skin_pigmentation1.22549445
44MP0005365_abnormal_bile_salt1.20196371
45MP0000569_abnormal_digit_pigmentation1.18418458
46MP0001968_abnormal_touch/_nociception1.17420563
47MP0001756_abnormal_urination1.16789327
48MP0001986_abnormal_taste_sensitivity1.14114615
49MP0002139_abnormal_hepatobiliary_system1.13430168
50MP0002210_abnormal_sex_determination1.08823855
51MP0004957_abnormal_blastocyst_morpholog1.08705557
52MP0002006_tumorigenesis1.06155287
53MP0003172_abnormal_lysosome_physiology1.06009658
54MP0010094_abnormal_chromosome_stability1.05736848
55MP0005391_vision/eye_phenotype1.05405629
56MP0002332_abnormal_exercise_endurance1.04434470
57MP0009745_abnormal_behavioral_response1.04354734
58MP0000372_irregular_coat_pigmentation1.02417799
59MP0006036_abnormal_mitochondrial_physio1.00429085
60MP0003136_yellow_coat_color1.00222202
61MP0002102_abnormal_ear_morphology0.99072695
62MP0001919_abnormal_reproductive_system0.98082702
63MP0008995_early_reproductive_senescence0.96689056
64MP0002733_abnormal_thermal_nociception0.95847628
65MP0000465_gastrointestinal_hemorrhage0.90543911
66MP0001800_abnormal_humoral_immune0.87621350
67MP0001984_abnormal_olfaction0.86275908
68MP0002638_abnormal_pupillary_reflex0.86104046
69MP0005389_reproductive_system_phenotype0.84506364
70MP0002234_abnormal_pharynx_morphology0.82647377
71MP0001666_abnormal_nutrient_absorption0.82176388
72MP0005257_abnormal_intraocular_pressure0.80993012
73MP0003638_abnormal_response/metabolism_0.80597987
74MP0003137_abnormal_impulse_conducting0.78415592
75MP0001929_abnormal_gametogenesis0.78384543
76MP0000613_abnormal_salivary_gland0.78364384
77MP0000653_abnormal_sex_gland0.78008582
78MP0001145_abnormal_male_reproductive0.76435716
79MP0001485_abnormal_pinna_reflex0.75358905
80MP0001119_abnormal_female_reproductive0.75263063
81MP0004215_abnormal_myocardial_fiber0.75096968
82MP0005636_abnormal_mineral_homeostasis0.72792664
83MP0004145_abnormal_muscle_electrophysio0.70507227
84MP0002557_abnormal_social/conspecific_i0.66920398
85MP0003937_abnormal_limbs/digits/tail_de0.65609129
86MP0001970_abnormal_pain_threshold0.63781037
87MP0005646_abnormal_pituitary_gland0.62271512
88MP0003786_premature_aging0.61918069
89MP0004036_abnormal_muscle_relaxation0.61172643
90MP0005377_hearing/vestibular/ear_phenot0.60941542
91MP0003878_abnormal_ear_physiology0.60941542
92MP0000639_abnormal_adrenal_gland0.60356410
93MP0003890_abnormal_embryonic-extraembry0.59927424
94MP0000631_abnormal_neuroendocrine_gland0.59411364
95MP0002254_reproductive_system_inflammat0.59180718
96MP0002272_abnormal_nervous_system0.58460474
97MP0001270_distended_abdomen0.58048806
98MP0003077_abnormal_cell_cycle0.57545264
99MP0008775_abnormal_heart_ventricle0.55563183
100MP0001486_abnormal_startle_reflex0.55269183

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.92655797
2Proximal tubulopathy (HP:0000114)4.93634111
3Supernumerary spleens (HP:0009799)4.90464099
4Tongue fasciculations (HP:0001308)4.84453062
5Agammaglobulinemia (HP:0004432)4.57966030
6Muscle fibrillation (HP:0010546)4.44241546
7Progressive external ophthalmoplegia (HP:0000590)4.11440537
8Delayed CNS myelination (HP:0002188)4.04791288
9Chronic sinusitis (HP:0011109)4.03796538
10Persistence of primary teeth (HP:0006335)4.03560794
11Azoospermia (HP:0000027)3.78712807
12Hepatic necrosis (HP:0002605)3.55448542
13Reduced antithrombin III activity (HP:0001976)3.54323082
14Prostate neoplasm (HP:0100787)3.45177167
15Generalized aminoaciduria (HP:0002909)3.40486627
16Hyperglycinemia (HP:0002154)3.36963260
17Testicular atrophy (HP:0000029)3.36112274
18Arthropathy (HP:0003040)3.32913401
19Abnormal spermatogenesis (HP:0008669)3.19059816
20Recurrent bronchitis (HP:0002837)3.16563975
21Nausea (HP:0002018)3.15899062
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.07974307
23Colon cancer (HP:0003003)3.05228424
24Hepatocellular necrosis (HP:0001404)3.01063972
25Renal cortical cysts (HP:0000803)2.96898324
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.87139883
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87139883
28Increased CSF lactate (HP:0002490)2.80502287
29Abnormality of the middle phalanges of the toes (HP:0010183)2.72578447
30Meckel diverticulum (HP:0002245)2.59618541
31Increased serum lactate (HP:0002151)2.56130796
32Abnormality of the corticospinal tract (HP:0002492)2.52331558
33Abnormality of the ileum (HP:0001549)2.51586788
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.51029048
35Hydroureter (HP:0000072)2.49821358
36Mitochondrial inheritance (HP:0001427)2.48065520
37Pancreatic cysts (HP:0001737)2.47146498
38Severe muscular hypotonia (HP:0006829)2.43844225
39Abnormality of the renal cortex (HP:0011035)2.43750956
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37307278
41Hypoglycemic coma (HP:0001325)2.35567167
42Abnormal glucose tolerance (HP:0001952)2.30839751
43Recurrent pneumonia (HP:0006532)2.28038567
44Palpebral edema (HP:0100540)2.24173684
45Abnormality of the labia minora (HP:0012880)2.22242942
46Hypergonadotropic hypogonadism (HP:0000815)2.15688038
47IgG deficiency (HP:0004315)2.13958860
48Methylmalonic acidemia (HP:0002912)2.12367098
49Aplasia/hypoplasia of the uterus (HP:0008684)2.12043699
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.11669694
51Rectal prolapse (HP:0002035)2.11325468
52Methylmalonic aciduria (HP:0012120)2.10040132
53Hypoplasia of the pons (HP:0012110)2.08882428
54Verrucae (HP:0200043)2.08740351
55Papilloma (HP:0012740)2.08740351
56Acute necrotizing encephalopathy (HP:0006965)2.06629027
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06572005
58Dicarboxylic aciduria (HP:0003215)2.06572005
59Cerebral palsy (HP:0100021)2.06255291
60Nephronophthisis (HP:0000090)2.06174518
61Abnormality of glycine metabolism (HP:0010895)2.05781324
62Abnormality of serine family amino acid metabolism (HP:0010894)2.05781324
63Progressive inability to walk (HP:0002505)2.05631708
64Abnormality of vitamin B metabolism (HP:0004340)2.03854174
65Progressive muscle weakness (HP:0003323)2.02612883
66Dysphonia (HP:0001618)1.96356172
67Exercise intolerance (HP:0003546)1.95902382
68Hyperglycinuria (HP:0003108)1.95855601
69Acute encephalopathy (HP:0006846)1.92406879
70Bronchitis (HP:0012387)1.92073362
71Lactic acidosis (HP:0003128)1.90696535
72Chromsome breakage (HP:0040012)1.88750820
73Abnormal mitochondria in muscle tissue (HP:0008316)1.85882777
74Pulmonary artery stenosis (HP:0004415)1.84899711
75Abnormality of the pons (HP:0007361)1.84880358
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84556369
77Protruding tongue (HP:0010808)1.81990989
78Abnormal pupillary function (HP:0007686)1.81062958
79Diminished motivation (HP:0000745)1.80844118
80Inability to walk (HP:0002540)1.80779731
81Abnormality of the renal collecting system (HP:0004742)1.80486171
82Respiratory failure (HP:0002878)1.80020297
83Sensory axonal neuropathy (HP:0003390)1.79850413
84Abnormality of the preputium (HP:0100587)1.79357824
85Abnormality of chromosome stability (HP:0003220)1.79164067
86Abnormality of the prostate (HP:0008775)1.76948615
87Hematochezia (HP:0002573)1.76141069
88Type I transferrin isoform profile (HP:0003642)1.75938691
89Pachygyria (HP:0001302)1.75211285
90Abnormality of the intrinsic pathway (HP:0010989)1.73706680
91Clubbing of toes (HP:0100760)1.73705065
92Abnormality of the phalanges of the hallux (HP:0010057)1.72980395
93Progressive macrocephaly (HP:0004481)1.71993777
94Abnormal albumin level (HP:0012116)1.71938919
95Hypoalbuminemia (HP:0003073)1.71938919
96Limb dystonia (HP:0002451)1.70192727
973-Methylglutaconic aciduria (HP:0003535)1.69006558
98Duplicated collecting system (HP:0000081)1.68523904
99Premature ovarian failure (HP:0008209)1.68344613
100Abnormality of the renal medulla (HP:0100957)1.67536580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.21961235
2EIF2AK13.38361710
3EIF2AK32.95853740
4ZAK2.95110080
5MKNK22.88955785
6ACVR1B2.57070575
7BMPR1B2.47213981
8SIK32.03683681
9MST42.03533448
10TSSK62.01311920
11TESK211.5202611
12PBK1.90947054
13MKNK11.79866009
14MAPKAPK31.60988753
15SRPK11.54049163
16STK391.32420277
17TGFBR11.21071156
18BUB11.19597003
19TYK21.12305719
20NME11.11717641
21OXSR11.06952540
22PLK41.06920911
23AKT31.03805282
24WNK41.03273349
25MAP3K130.99440786
26CDK80.97540526
27PKN20.97079347
28PNCK0.95790678
29FLT30.93303711
30MAP4K20.92108013
31MARK30.87645171
32FRK0.87165958
33TAF10.82272183
34ITK0.81006142
35EIF2AK20.72000409
36STK160.71868313
37CCNB10.67281695
38ADRBK20.64702128
39PLK30.64606478
40PRKD30.52723598
41TRIM280.52282238
42PHKG10.51646386
43PHKG20.51646386
44SIK20.49272359
45PIK3CG0.46010026
46TNK20.44659503
47CDK70.44530682
48TLK10.42747714
49WEE10.38895236
50PLK20.37243817
51WNK30.36417157
52PRKCG0.35586909
53TTK0.33176361
54PRKCE0.32910009
55KIT0.32408981
56MAPK130.31148519
57TYRO30.30843333
58DAPK10.30475023
59TIE10.30466548
60STK40.29845339
61BRD40.29399480
62PLK10.28812131
63STK30.28191254
64TRPM70.28130538
65CAMK2G0.28122533
66INSRR0.27888399
67NEK10.24690185
68CAMK2B0.24013749
69SYK0.23947401
70SIK10.23589215
71TAOK30.22884846
72MAP3K90.20564883
73CAMK2D0.20483182
74CAMK1G0.18461124
75FGFR20.18219334
76STK38L0.17965561
77ATM0.17946765
78RPS6KA40.17878457
79CSNK2A10.17103698
80TNIK0.16782273
81RPS6KA50.16732650
82NLK0.16080013
83IGF1R0.16024812
84OBSCN0.15889716
85PRKCI0.15751459
86MAP3K110.15272099
87PRKACG0.14667144
88PRKACA0.14656062
89MAP2K60.13392540
90MAP2K20.12491070
91MAP3K140.12339263
92KDR0.12299581
93IRAK10.11854133
94MAP3K40.11527307
95AURKB0.11200287
96TXK0.10638689
97BCR0.10133004
98FGFR10.09522486
99CSNK2A20.08421837
100VRK10.07931138

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.02993412
2Propanoate metabolism_Homo sapiens_hsa006403.42052958
3Protein export_Homo sapiens_hsa030603.23976717
4Asthma_Homo sapiens_hsa053103.17888808
5Folate biosynthesis_Homo sapiens_hsa007903.03438621
6Proteasome_Homo sapiens_hsa030502.98622609
7One carbon pool by folate_Homo sapiens_hsa006702.97401701
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.53021296
9Allograft rejection_Homo sapiens_hsa053302.38624615
10Autoimmune thyroid disease_Homo sapiens_hsa053202.33230473
11RNA polymerase_Homo sapiens_hsa030202.10918120
12Steroid biosynthesis_Homo sapiens_hsa001002.02593131
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97494644
14Sulfur metabolism_Homo sapiens_hsa009201.83582787
15Oxidative phosphorylation_Homo sapiens_hsa001901.82063430
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71448988
17Parkinsons disease_Homo sapiens_hsa050121.69134163
18RNA degradation_Homo sapiens_hsa030181.65100419
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.63307073
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57952895
21Primary immunodeficiency_Homo sapiens_hsa053401.40417791
22Linoleic acid metabolism_Homo sapiens_hsa005911.37448120
23Homologous recombination_Homo sapiens_hsa034401.35362289
24Tryptophan metabolism_Homo sapiens_hsa003801.30833304
25Mismatch repair_Homo sapiens_hsa034301.28700888
26Caffeine metabolism_Homo sapiens_hsa002321.26705789
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23818254
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22176738
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20731075
30Purine metabolism_Homo sapiens_hsa002301.20001597
31Butanoate metabolism_Homo sapiens_hsa006501.13017919
32Fatty acid elongation_Homo sapiens_hsa000621.12863206
33Spliceosome_Homo sapiens_hsa030401.11015841
34Pyrimidine metabolism_Homo sapiens_hsa002401.10629941
35Fanconi anemia pathway_Homo sapiens_hsa034601.07050544
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06722377
37Nitrogen metabolism_Homo sapiens_hsa009101.04953544
38RNA transport_Homo sapiens_hsa030131.02932308
39Olfactory transduction_Homo sapiens_hsa047401.02503095
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01272338
41beta-Alanine metabolism_Homo sapiens_hsa004100.99828191
42Type I diabetes mellitus_Homo sapiens_hsa049400.97971298
43Selenocompound metabolism_Homo sapiens_hsa004500.95774960
44Hedgehog signaling pathway_Homo sapiens_hsa043400.94249666
45Ovarian steroidogenesis_Homo sapiens_hsa049130.93010134
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92659023
47Mineral absorption_Homo sapiens_hsa049780.91837645
48Basal transcription factors_Homo sapiens_hsa030220.90723233
49Huntingtons disease_Homo sapiens_hsa050160.89752094
50Retinol metabolism_Homo sapiens_hsa008300.89380557
51Hematopoietic cell lineage_Homo sapiens_hsa046400.86056059
52Peroxisome_Homo sapiens_hsa041460.83415768
53Antigen processing and presentation_Homo sapiens_hsa046120.79041118
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73493290
55Base excision repair_Homo sapiens_hsa034100.71185938
56Taste transduction_Homo sapiens_hsa047420.67828864
57Alzheimers disease_Homo sapiens_hsa050100.65858850
58Insulin secretion_Homo sapiens_hsa049110.64683683
59Cardiac muscle contraction_Homo sapiens_hsa042600.64196178
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64009396
61Systemic lupus erythematosus_Homo sapiens_hsa053220.63302464
62Salivary secretion_Homo sapiens_hsa049700.62917543
63Graft-versus-host disease_Homo sapiens_hsa053320.62895485
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62659310
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.62331880
66Carbon metabolism_Homo sapiens_hsa012000.61591925
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61364858
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61044038
69Metabolic pathways_Homo sapiens_hsa011000.60488721
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60142957
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.59649191
72ABC transporters_Homo sapiens_hsa020100.56703775
73Non-homologous end-joining_Homo sapiens_hsa034500.56520718
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56420040
75DNA replication_Homo sapiens_hsa030300.55455631
76Serotonergic synapse_Homo sapiens_hsa047260.54477405
77Morphine addiction_Homo sapiens_hsa050320.54370866
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.53982846
79Ribosome_Homo sapiens_hsa030100.53817806
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52491640
81Pyruvate metabolism_Homo sapiens_hsa006200.51681047
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50879882
83Ether lipid metabolism_Homo sapiens_hsa005650.48903033
84GABAergic synapse_Homo sapiens_hsa047270.48769924
85Fatty acid degradation_Homo sapiens_hsa000710.48521128
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46222796
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45817586
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44800038
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43274328
90Chemical carcinogenesis_Homo sapiens_hsa052040.42004613
91Legionellosis_Homo sapiens_hsa051340.39580416
92Arachidonic acid metabolism_Homo sapiens_hsa005900.39121776
93Glutathione metabolism_Homo sapiens_hsa004800.38346569
94Thyroid hormone synthesis_Homo sapiens_hsa049180.36992042
95Fatty acid metabolism_Homo sapiens_hsa012120.36936814
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.35780213
97Vitamin B6 metabolism_Homo sapiens_hsa007500.35649162
98Circadian entrainment_Homo sapiens_hsa047130.35375755
99mRNA surveillance pathway_Homo sapiens_hsa030150.35218480
100Glutamatergic synapse_Homo sapiens_hsa047240.32815737

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